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Hazard

The Hazard tab displays various types of toxicity data, including publicly available toxicity dose–effect related summary values typically used in risk assessments, that are aggregated into the ToxValContains data from 34 unique sources including (EPA, DOE, DOD, CDC/ATSDR, FDA, ECHA, EFSA, Health Canada, and CalEPA). Values from individual studies or chemical-level assessments. Focused on quantitative values such as LOAELs, NOAELs, BMDs, LD50s and RfDs. Data covers both mammalian studies relevant for human health risk assessments as well as ecological studies. Current database contains approximately 700,000 records for over 25,000 chemicals. database and integrated into the Dashboard. Data include Point of Departure (POD) data collected from data sources within ACToRAggregated Computational Toxicology Resource. and ToxRefDBToxicity Reference Database (ToxRefDB) contains information from over 5000 in-vivo toxicity studies (study specifications: US Environmental Protection Agency and the National Toxicology Program). , and no-observed and lowest-observed (adverse) effect levels (NOEL, NOAEL, LOEL, LOAEL) data extracted from repeated dose toxicity studies submitted under REACH. Also included are reference dose and concentration values (RfDs and RfCs) from EPA’s Integrated Risk Information System (IRISIntegrated Risk Information System. ) and dose descriptors from EPA’s Provisional Peer-Reviewed Toxicity Values (PPRTVProvisional Peer-Reviewed Toxicity Values. ) documents. Acute toxicity information was extracted from a number of different sources, including: OECD eChemPortal, ECHA (European Chemicals Agency), NLM (National Library of Medicine), HSDB (Hazardous Substances Data Bank), ChemIDplus via EPA TEST (Toxicity Estimation Software Tool), and the EU JRC (Joint Research Centre) AcutoxBase [REFs]. Data from the EU COSMOS project has also been included.

Hazard table for Lethality Effect Level (Human)

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