CCD Help Pages

GenRA

The GenRA (Generalized Read Across) tab links to a separate tool which opens in a new tab.

GenRA provides a means to identify potential source analogues for a given target chemical, the center of the radial plot (below). The radial plot displays K source analogues (otherwise called nearest neighbours) where K can be set from 1 to 15. Analogues can be filtered based on the availability of in vivo toxicity data. Analogues are ordered in decreasing order of similarity in a clockwise manner in the plot, starting with the most similar at the top. The similarity indices are annotated c (chemistry), b (bioactivity), or t (toxicity) depending on the similarity context selected. Analogues may be identified using chemical descriptors or bioactivity descriptors. There are 3 different types of chemical descriptors included that are fingerprint representations of chemical structure - Morgan fingerprints, torsion fingerprints and chemotypes. Bioactivity descriptors make reference to a fingerprint representation of hitcalls from ToxCast or HTPPHigh Throughput Phenotypic Profiling. EPA article. assays. For more details watch the videoEXIT.

Screen shot from the GenRA application, another EPA tool linked from the Dashboard.

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