The GenRA (Generalized Read Across) tab links to a separate tool which opens in a new tab.
GenRA provides a means to identify potential source analogues for a given target chemical, the center of the radial plot (below). The radial plot displays K source analogues (otherwise called nearest neighbours) where K can be set from 1 to 15. Analogues can be filtered based on the availability of in vivo toxicity data. Analogues are ordered in decreasing order of similarity in a clockwise manner in the plot, starting with the most similar at the top. The similarity indices are annotated c (chemistry), b (bioactivity), or t (toxicity) depending on the similarity context selected. Analogues may be identified using chemical descriptors or bioactivity descriptors. There are 3 different types of chemical descriptors included that are fingerprint representations of chemical structure - Morgan fingerprints, torsion fingerprints and chemotypes. Bioactivity descriptors make reference to a fingerprint representation of hitcalls from ToxCast or HTPPHigh Throughput Phenotypic Profiling. EPA article. assays. For more details watch the videoEXIT.
