Film: The Hunger

Weapon: A legion of mummified ex-boyfriends led by David Bowie.

If you're a fan of The Venture Brothers, you know there is no greater force in the world than David Bowie. Not even Iggy Pop or Klaus Nomi can stand up to his bad-ass nature. This is further proven in The Hunger ,Tony Scott's adaptation of Whitley Strieber's novel about Miriam Blaycock (always hot Catherine Deneuve) a female vampire who continues to take male lovers who have eternal life--just not youth.
 
Bowie is the latest of her conquests and discovers his sad fate: being stuffed into a coffin above her apartment with all her other boyfriends after he pulls a Logan's Run and hits over 300. Eventually, after hitting on Susan Sarandon, the mummy ex-boyfriends come back to life to throw Miriam over a railing and into the sunrise to finally get some rest.

Moral of the story? You can't stop David Bowie, even if you are an all-powerful vampire.