Film: Vampire Hunter D

Weapon: A Symbiotic Right Hand--no, really.

Vampire Hunter D is notable for a lot of reasons. It was the introduction for a lot of nubile youth on the then Sci-Fi Channel to anime on a Saturday morning. More, it was hyper-violent and sexualized anime, complete with bodies being sliced up, blood flowing everywhere and the eventual identity reveal  of the snide, mocking half-human, half-vampire voice of D (or "Dhampire") . Guess who his father was? Rhymes with 'Ackula'.

A face on a hand capable of eating magic, ghosts and sucking the life out of all manner of monsters was the protagonist's best friend and would be the source of countless innuendo for fan fiction until the sequel Vampire Hunter D: Bloodlust, when the hand got even raunchier and deadlier.