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Wellness Wednesday

Webinar Series

Topic: Neurotransmitter Primer

April 4, 2018

Join Labrix clinical staff and special guests on the first Wednesday of every month at 9:30 AM and 12:00 PM PST. This free, live webinar series will cover a variety of neuroendocrine topics that will enhance your knowledge, with clinically applicable testing and treatment considerations.

A4M

Hollywood, FL: April 12-14, 2018

Stop by the Labrix booth at the A4M conference in Florida next month, to speak with Labrix National Sales Manager Heather Cadwallader.

 

CNDA

Torrance, CA: April 14-15, 2018

Labrix representatives will be exhibiting at the CNDA conference in Torrance, CA in mid April.

 

Endometriosis: A Disorder

of Estrogen Dominance

 

Published on 3/21/18

Estrogen is the hormone that makes women “women,” in its support of the female organs that support human life. It initiates the development of sex characteristics at puberty by stimulating the growth of endometrial and breast tissue. Every month it stimulates the growth of the follicle which releases the egg. It supports vaginal tissues and stores fat to support a woman who might become pregnant or nursing. Other growth-related processes attributed to estrogen are preventing bone loss and maintaining collagen in the skin and connective tissues. Estrogen also aids in the synthesis of neurotransmitters, especially serotonin and dopamine, and supports the transportation of glucose across the blood brain barrier.

While estrogen contributes to fertility and a woman’s monthly cycle, it can run amok when it goes unchecked by enough progesterone, the hormone that promotes differentiation. A common presentation of unbalanced estrogen is endometriosis. Endometriosis is the presence of endometrial-like tissue outside of the uterus, primarily located on the pelvic peritoneum, ovaries and rectovaginal septum. Endometriosis has a high association with adenoymyosis, endometrial tissues growing outside of the uterine wall; and fibroids, a benign tumor of muscular tissue in the wall of the uterus. 

Endometriosis and its cousins adenomyosis and uterine fibroids, often difficult to tell apart, are the reasons that many women experience pelvic pain and bleeding, and make visits to their gynecologists. While only 6-10% of women of reproductive age experience endometriosis, 50-60% of the pelvic pain experienced by teenage girls is caused by endometriosis, and endometriosis is present in 50% of women with infertility.

Endometriosis is also associated with inflammation, in the form of elevated cytokines and homocysteine. These cytokine elevations put a woman at higher risk for autoimmune diseases such as Crohn’s and Ulcerative Colitis, Grave’s, Hashimoto’s, and Celiac disease. Amazingly, endometriosis lesions express aromatase and synthesize their own estradiol from testosterone, creating more estrogen and inflammation, and contributing to estrogen dominance! Endometriosis is also associated with an increased risk of ovarian endometrioid and clear-cell cancers, as well as other cancers such as non-Hodgkins lymphoma and melanoma. 

In short, the estrogen dominance that leads to endometriosis breeds growth in the form of more endometriosis, more estrogen production and more inflammation, and may even contribute to the growth of cancer. The conventional treatment for endometriosis includes NSAIDS, GnRH agonists (Lupron), oral contraceptives, and surgery. Because progesterone tends to be decreased in women with endometriosis, progesterone supplementation can be a more natural alternative to pharmaceuticals. Progesterone can serve as an important component in breaking the cycle of estrogen dominance as it stabilizes and slows the cell growth associated with estrogen. Many women are desperate for a solution to their pain and will gladly start with a trial of progesterone.

Consider salivary hormone testing in your patients, as the Pg/E2 ratio can play an important role in determining a progesterone-based treatment plan for women with endometriosis at any age.  

 

References

1.Lotto V, Choi SW, Friso S. Vitamin B6: a challenging link between nutrition and inflammation in CVD. Br J Nutr. 2011;106(2):183-95.

Zhang D, Wen X, Wu W, Guo Y, Cui W. Elevated homocysteine level and folate deficiency associated with increased overall risk of carcinogenesis: meta-analysis of 83 case-control studies involving 35,758 individuals. PLoS ONE. 2015;10(5):e0123423.

Giudice LC. Clinical practice. Endometriosis. N Engl J Med. 2010;362(25):2389-98.

Zheleva-Dimitrova, D. Obreshkova, D. & Nedialkov, P. Antioxidant Activity of Tribulus Terrestris – A Natural Product of Infertility Therapy

Kadam PD, Chuan HH. Erratum to: Rectocutaneous fistula with transmigration of the suture: a rare delayed complication of vault fixation with the sacrospinous ligament. Int Urogynecol J. 2016;27(3):505.

Sir T. [Do androgens modulate luteinizing hormone secretion in women?]. Rev Med Chil. 1997;125(6):710-8.

 

Sleep: The Emerging Science and Its Clinical Implications

By Krista Anderson Ross, ND

Staff Physician, Labrix

While it’s easy to believe that sleep deprivation is a manifestation of the modern world and the effects of increasingly occupied opposable thumbs, the first known study on the negative effects of sleeplessness was published in 1896 in the Journal of Psychological Review, just 17 years after the invention of the light bulb. Thus was born the industrial revolution, a 24-hour work force, and the wakeful work ethic.

Read the entire article at ndnr.com