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Advanced Workshop

Las Vegas, NV: February 9-11, 2018

Only a few seats left!

Register before it's SOLD OUT!

Interested in gaining a deeper understanding of how hormone and neurotransmitter imbalances are affecting your patient’s health? Register now for the Labrix Advanced Workshop to secure your seat! Includes a NeuroAdrenal Panel (Value $215).

 

Wellness Wednesday

Webinar Series

Topic: Belly Fat and Elevated Androgens in Women

February 7, 2018

Join Labrix clinical staff and special guests on the first Wednesday of every month at 9:30 AM and 12:00 PM PST. This free, live webinar series will cover a variety of neuroendocrine topics that will enhance your knowledge, with clinically applicable testing and treatment considerations.

IWHIM

Portland, OR: January 26-28, 2018

Labrix Staff Physician Dr. Lylen Ferris will be speaking at the IWHIM conference in Portland, OR this weekend. Come visit the Labrix booth at the conference and learn more about Labrix hormone and neurotransmitter testing.

IHS

New York, NY: February 22-24, 2018

Labrix will be in New York for the IHS conference next month. Come chat with our booth representative and learn more about testing with Labrix.

Secretory IgA

 

Published on 1/25/18

Exciting News!

Labrix is now offering secretory immunoglobulin A (sIgA) testing. This is a valuable tool that allows providers to more deeply assess the stress body’s response. In this newsletter we dive into the value of sIgA and its clinical relevance.

What is it?

Every mucosal membrane surface represents a large portal of entry for pathogenic bacteria, viruses, and yeasts. The predominant antibody at these mucosal membranes is sIgA, the body’s first line of defense against toxins. IgA accounts for approximately 15 – 20% of serum immunoglobulin, but is the most abundant immunoglobulin in secretions: saliva, tears, colostrum, bronchial, intestinal, and G.I secretions. 

SIgA measured in the saliva primarily provides insight into the body’s stress response, but SIgA production is also driven in response to pathogens and their virulence factors, and also in response to intestinal microbes or commensal microflora. Factors affecting sIgA levels include stress, nutrient levels, interactions with other commensal flora or pathogens, and inflammation. An imbalanced sIgA level may provide a link between mucosal imbalances and systemic illness.

What it is not:

SIgA is not IgA, a related antibody that is commonly tested in the blood along with IgE and IgG in immunity and allergy problems. Secretory IgA is independent of blood IgA levels; they may not correlate with one another. 

Level Interpretation:

Low:

Deficiency of sIgA is a common finding. Decreased levels of sIgA are commonly seen in individuals with low immune system functioning, and are a sign of chronic, ongoing psychological and/or physical stress (HPA axis dysfunction) to the body which has depleted sIgA reserves. 

SIgA declines with age, and can be seen with some chronic gastrointestinal disorders such as Celiac and IBD, asthma, autoimmune conditions, candidiasis, and chronic dermatological conditions. Lower levels have been associated with increased risk for periodontal disease and caries as well as increased sensitivity to foods. Certain medications, including NSAIDS, can lower levels. 

High:

Elevated levels of sIgA may be reflective of acute psychological and/or physical stressors, and can be associated with an upregulated, active immune or inflammatory response. High levels are often found in patients with chronic infections (CMV, EBV, HIV and infections of the GI tract).

Treatments:

Lifestyle improvements, stress management and improved nutritional status may all lead to optimal sIgA levels.

  • HPA Axis Optimization:

        Consider testing diurnal cortisol levels to assess for HPA axis         dysfunction. If HPA axis dysfunction is found, see Labrix document         “Adrenal Dysfunction Stages and Considerations” for treatment options.

  • Nutrition:

        Choline, essential fatty acids, glutathione, glycine, glutamine,         phosphatidylcholine, vitamin C and zinc are all required in the production         of sIgAProbiotic strains shown to increase sIgA levels are: Lactobacillus         rhamnosus GGLactobacillus acidophilus, Bifidobacterium bifidum,         Bifidobacteruium infantis and Saccharomyces boulardii.

  • Immune Support:

        This may be immune support directed against a certain pathogen or         support of the immune system in a general sense, including a whole-food         diet and exercise. Though a non-exhaustive list, Echinacea, elderberry,         vitamin D, and ginger have all been shown to provide immune enhancing         properties.

SIgA is tested in saliva, and can be added to any salivary hormone panel, but is especially helpful when paired with salivary cortisol for an in-depth assessment of the body’s stress response. 

 

References

       Brandtzaeg P. Do salivary antibodies reliably reflect both mucosal and systemic immunity?. Ann N Y Acad Sci. 2007;1098:288-311

        Buts JP, Bernasconi P, Vaerman JP, Dive C. Stimulation of secretory IgA and secretory component of immunoglobulins in small intestine of rats treated with Saccharomyces boulardii. Dig Dis Sci. 1990;35(2):251-6.

        Crawford, J.M., Taubman, M.A., Smith D.J. Minor salivary glands as a major source of secretory immunoglobulin A in the human oral cavity. Science. 1975;190(4220): 1206-9.

        Goyal N, Shukla G. Probiotic Lactobacillus rhamnosus GG modulates the mucosal immune response in Giardia intestinalis-infected BALB/c mice. Dig Dis Sci. 2013;58(5):1218-25.

        Hucklebridge F, Clow A, Evans P. The relationship between salivary secretory immunoglobulin A and cortisol: neuroendocrine response to awakening and the diurnal cycle. Int J Psychophysiol. 1998;31(1):69-76.

        Jackson DE, Lally ET, Nakamura MC, Montgomery PC. Migration of IgA-bearing lymphocytes into salivary glands. Cell Immunol. 1981;63(1):203-9

        Mantis NJ, Rol N, Corthésy B. Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut. Mucosal Immunol. 2011;4(6):603-11.

        Miletic. I. D., S. S. Schiffman, V. D. Miletic, and E.A. Sattel3~Mlller. Salivary lgA Secretion Rate in Young and Elderly Persons. Physiol. Behav. 1996; 60: 243-248

        Salimetrics Salivary ELISA Assay Kits, Saliva Testing Service, Saliva Training Courses. (n.d.). Retrieved March 21, 2017, from https://www.cambridgenetwork.co.uk/directories/companies/1272/products/1053/

        Tejada-simon MV, Lee JH, Ustunol Z, Pestka JJ. Ingestion of yogurt containing Lactobacillus acidophilus and Bifidobacterium to potentiate immunoglobulin A responses to cholera toxin in mice. J Dairy Sci. 1999;82(4):649-60

        Tsujita, S., & Morimoto, K. (1999). Secretory IgA in saliva can be a useful stress marker. Environmental Health and Preventive Medicine,4(1), 1-8. doi:10.1007/bf02931243

 

Choose from two LIVE Online Training Webinars with world-class hormone and neurotransmitter expert Gregory Zengo, MD. These full-day courses include up to 9 hours of CME credit and up to 6 months of private consultations with Dr. Zengo. 

Live Online Simulcast: Saliva/BHRT

February 24, 2018


Dr. Zengo will teach you how to optimize your patients' sex hormones and adrenals in this Bio-identical Hormone Training Course. 


In this comprehensive course, you'll learn how to:


  • Use salivary hormone testing and BHRT to support patients with adrenal fatigue, menopause, PMS, and andropause.
  • Prescribe and use bio-identical hormones to achieve successful patient outcomes.
  • Implement BHRT service into your practice. The course includes customizable office forms and advertising materials.
  • Includes 1 Comprehensive Plus Hormone Profile from Labrix, plus two panels at 50% off. Course approved for up to 8 CME Credit Hours.


Live Online Simulcast: Neurotransmitter/GI

February 25, 2018


Learn from the best. Dr. Zengo's PracticalCME has the world’s only CME-accredited Neurotransmitter and GI Training Course.


In this comprehensive course, you'll be empowered with the skills to:


  • Use urinary neurotransmitter testing to enhance your patients' neurotransmitter balance. Support patients with anxiety, depression, insomnia, cravings, and addiction.
  • Use GI stool testing to support patients' gut health. Learn how to address issues like leaky gut, dysbiosis, yeast, maldigestion, and weight loss. 
  • Provide your BHRT patients with additional tools to manage symptoms and improve overall health. 
  • Includes 1 NeuroBasic Profile from Labrix, plus two panels at 50% off. Course approved for up to 9 CME Credit Hours.