Curt's family life has been one giant tragedy. Curt's wife and son (Martha and Billy) lived in fear of Curt reverting to the Lizard and even had to be relocated by Spider-Man at one point. Unfortunately, it was too late because the real danger didn't come from the Lizard's teeth, but instead pollution from their past.
Martha and Billy were diagnosed with cancer after being exposed to carcinogens for years while living next to an industrial plant in Florida. Martha died from the long-term illness but Billy survived to face a far more painful end. During the story "The Gauntlet," Lizard returned and Connors is seemingly no longer in control. In a dark and emotional twist, the Lizard ate Billy. Before being turned into reptile food, the child muttered "You're going to kill me, aren't you? I knew it... I've always known it."
