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Long-term drug use can create alterations in various chemical processes and neural pathways in the brain. They can impair your judgement, decision-making, memory, and learning capacity. Together, these brain alterations might lead you to seek out and consume drugs in ways that are beyond your control.
Biology. The genes that a person was born with can make up half of their risk of addiction. A person's risk of addiction and drug use may also depend upon their gender, race, and if they have any other mental disorders.
The long-term use may affect a number of cognitive functions and behavior, including learning, judgement and decision-making, stress, memory and behaviour. Many people who abuse drugs continue to do so despite realizing the dangers.