Host Affinity Rules and CPU Pinning
VMware host affinity rules enable specifying which ESX/ESXi hosts a virtual machine can or cannot run under. CPU pinning ties a specific workload to a specific processor within an ESX/ESXi host. Thus, when DRS is enabled, the rules for which ESX/ESXi hosts a virtual machine can be enforced regardless of the load.
Zerto Virtual Replication works whether host affinity and CPU pinning is used or not.
Note: Host affinity rules are applied to Virtual Replication Appliances (VRAs) to tie it to the host.