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Objective: To assess the efficacy and safety of a novel long-acting im testosterone undecanoate (TU) formulation in comparison with testosterone enanthate (TE). JavaScript is currently disabled, this site works much better if you enable JavaScript in your browser. Licence fees: A licence fee will be charged for any media (low or high resolution) used in your project. Nebido contains the active ingredient testosterone undecanoate and may be given as a replacement therapy in patients with low levels of the male hormone.
Results: TU and TE produced no statistically significant improvements in grip strength over the first 30 weeks, which only occurred after approximately 90 weeks when all subjects received TU. The decline of androgen levels in elderly men and its clinical and therapeutic implications. There were no changes in body mass index with TU and TE, neither in the follow-up period when all patients received TU.

Total serum cholesterol, LDL cholesterol, and triglycerides declined over the first 30 weeks, while plasma HDL also declined. Hemoglobin and hematocrit values significantly increased over the first 30 weeks in both treatment groups and then no further increase was observed. In both treatment groups, serum prostate specific antigen levels rose slightly after 30 weeks, with no further increase over the first 12 months, remaining stable within the normal range.
Conclusions: Administration of TU every 12 weeks is at least as safe and efficacious for treatment of hypogonadal men as TE, with a substantially lower frequency of administration.
Follow-up over 114 weeks, when all subjects received TU, showed an excellent profile of efficacy and safety.
Intramuscular testosterone undecanoate: pharmacokinetic aspects of a novel testosterone formulation during long-term treatment of men with hypogonadism.
Intramuscular injection of testosterone undecanoate for the treatment of male hypogonadism: phase I studies.

Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolemia in hypogonadal men with type 2 diabetes. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone.
Reversal of the sex difference in serum leptin levels upon cross-sex hormone administration in transsexuals.
Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men.

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