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admin | Natural Testosterone Replacement | 08.09.2014
The largest problem for both men and women is unopposed estrogen dominance.A A  Excessive estrogen levels cause a long list of health risks (read some of Dr.
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A pure, light moisturizing cream with Micronized USP Progesterone in the amounts recommended by leading authorities.
Karuna Corporation has provided exceptional nutritional therapeutics to healthcare professionals and their patients since 1981. As women age and go through menopause, their production of progesterone decreases, resulting in what many deem a progesterone a€?deficiencya€™. For fighting menopause symptoms, estrogen dominance, depression, migraines, PMS, and all of the womena€™s fibrosis diseases (fibrocystic breast disease, endometriosis, ovarian cysts, uterine fibroids). Myomin is an all natural formula of Chinese herbs that has been shown to help metabolize unhealthy estrogens and promote proper hormonal balance. Hospital research has shown that Myomin helps to reduce the size and symptoms of myomas (fibroids) found in the breast, uterus, and ovaries. Myomin has been shown to inhibit aromatase, a key enzyme involved in the synthesis of estrogen. Since estrogen control is essential, not just for fighting cancer, but for fibroids, endometriosis, fibrocystic breast disease, and ovarian cysts in women and overcoming andropause in men, the Myomin is applicable to anyone needing to gain control over their estrogen dominance. Myomin acts as both an estrogen blocker and aromatase inhibitor (keeps the body from making estrogen) without side effects or heavy toxicity and has been reported to reduce the size and symptoms of myoma. Myomin is often suggested for those who are menopausal to post-menopausal because they are not producing as much natural estrogen; although, it can be used safely by women in their twenties, thirties, and forties. Every day you’ve been pushing harder and harder in the gym and have been eating clean, but the scale hasn’t shown that—not an ounce has been gained. Testosterone is what defines male vitality and is a necessity for reproductive and sexual function. A natural testosterone supplement can be the solution for a workout rut while also amplifying virility. Testro-XL’s synergistic formula contains three leading ingredients—dehydroepiandrosterone (DHEA), diindolymethane (DIM), tribulus terrestris—that can positively impact t-levels and muscle-building aspects.
So if you want to get past that workout plateau and have a hotter sex life, then consider using Testro-XL Creme. An Estrogen blocking formulation designed to increase muscle tone whilst dramatically decreasing water and fat retention leading to a tightening, smoothing and firming effect on the body.
Estrogen dominance can increase fat deposits and accumulation in isolated regions creating an oestrogen dominant body shape. Midnight Horror (Oroxylum indicum) is an extremely potent and natural source of the powerful flavones Chrysin (5,7-dihydroxyflavone, or 5,7-dihydroxy-2-phenyl-(9CI)) and Baicalein. Bladderwrack (Fucus vesiculosus) is a potent source of iodine and other compounds including fucoidan and fucophlorethols, which have demonstrated powerful anti-estrogen properties. Black pepper essential oil (piper nigrum) enhances transdermal absorption of the above mentioned active ingredients. Massage Block E3 serum into isolated fatty deposits on the chest to tighten, firm and flatten. In men, Block E3 can improve the appearance of the chest. Massage Block E3 serum into stubborn isolated pockets of regional fat on the lower abdomen, hips and buttocks.
Massage Block E3 serum into stubborn isolated pockets of regional fat on the hips, buttocks and thighs.
Water, Midnight horror Oroxylum indicum (containing Chrysin as a natural component), Bladderwrack Fucus vesiculosus, carbomer, trolamine, glycerine, polysorbate, phenoxyethanol, caprylyl glycol, black pepper Piper nigrum essential oil. Raised intracellular oestradiol levels in men, induce and promote obesity, gynaecomastia, metabolic syndrome, type two diabetes, benign prostatic hypertrophy and prostate cancer.
One of the key features of oestrogen dominance is that it can be a self-perpetuating vicious cycle that can be isolated from the rest of the body. Meaning the normal regulation and hormonal modulation pathways can sometimes not be able to control it or even be aware that it is happening. Testosterone is metabolised to oestradiol by aromatase, in the cytoplasm of adipocytes, breast cells, endothelial cells and prostate cells, to increase intracellular oestradiol concentration at the expense of testosterone. Increased aromatase activity will increase estrogen and lower testosterone and increase the activation of the mainly proliferative estrogen receptors to induce fat cell production and growth disorders in oestrogen-sensitive tissues like breast and prostate.
Subcutaneous adipose tissue (fat directly under the skin) and breast tissue (in males and females) are rich sources of aromatase. Aromatase in breast tissue has been the target for a significant amount of breast cancer research. Our innate defence mechanisms respond to stress by releasing a vast myriad of chemicals. Initially inflammatory and immune stimulating compounds are released and are shortly followed seconds later with the hormone cortisol. Oestrogen can be made in the fat cells and work within the very same fat cell or its neighbouring fat cells by binding to estrogen receptors and triggering estrogen activity. Oestrogen dominant fat tissue can encapsulate itself away from the rest of the body. The body can compensate for surges in testosterone by increasing the conversion of the elevated testosterone to estradiol via aromatase. Organochlorines used in pesticides, dry cleaning, bleaching of feminine-hygiene products and the manufacture of plastics.
Bisphenol-A (BPA) used in many plastic bottles and plastic linings in food cans and juice containers.
Sunscreens contain benzophenone-3, homosalate, 4-methyl-benzylidene camphor, octal-methoxycinnamate, octal-dimethyl-PABA.
This process of increased oestrogen increasing fat cell production creates a vicious cycle. Fat cells secrete inflammatory mediators which up-regulate aromatase activity and increase oestrogen production within the fat cell and neighbouring fat cells, and this insulin and inflammation contribute to the generation of more fat cells. It is of no surprise that this particular type of fatty tissue can become isolated and resistant to diet, exercise, medication and supplementation.
Midnight Horror (Oroxylum indicum) is an extremely potent and natural source of the powerful flavones Chrysin (5, 7-dihydroxyflavone, or 5, 7-dihydroxy-2-phenyl-(9CI)) and Baicalein. Chrysin and Baicalein exhibit numerous biological activities, including anti-inflammatory and anti-allergic activities. The flavones Chrysin and Baicalein inhibit the activity of aromatase (CYP19), thus decreasing estrogen biosynthesis and producing anti-estrogenic effects.
Flavones are plant chemicals and are known to be competitive inhibitors of cytochrome P450 aromatase with respect to the androgen substrate. Flavones such as Chrysin have very poor oral bioavailability, less than 5% of an oral dose can get past first pass metabolism and digestive tract. The ATP trade secret process of micronizing the particle size and combining with permeation enhancers will maximise the percutaneous absorption. Block E3 is designed to work locally on regional fat deposits and breast tissue and not systemically.
Possesses anti-aging activities for skin; improving dermal collagen integrity and elasticity.
Inhibits glycation, which is damage to protein structures caused by binding and oxidation of sugar. Many scientific papers have discussed and studied the Asian diet its association with lower incidences of oestrogen related cancers.

Bladderwrack is a potent source of iodine and other compounds including fucoidan and fucophlorethols, which have demonstrated powerful anti-estrogen properties. Bladderwrack extract inhibits the binding of estradiol to estrogen receptor alpha and beta. Phloroglucinol derivatives, belonging to the class of fucophlorethols, isolated from bladderwrack have been shown to be potent aromatase inhibitors. Bladderwrack is a rich source of Iodine, which has important functions in breast tissue in men and women.
As SF is predominately located under the skin; it is more efficient to utilize transdermal technology and bypass the above-mentioned hurdles associated with oral delivery systems. Mohammed HA, Ba LA, Burkholz T, Schumann E, Diesel B, Zapp J, Kiemer AK, Ries C, Hartmann RW, Hosny M, Jacob C. Campbell, DR and Kurzer, MS: Flavonoid Inhibition of Aromatase Enzyme Activity in Human Preadipocytes.
Kellis, JT and Vickery, LE: Inhibition of Human Estrogen Synthetase (Aromatase) by Flavones. My mum is perimenopausal and has been taking Alpha Venus & Alpha Mars (as suggested in your podcast) and We have noticed a huge change in her moods (she is MUCH happier!). Finally, my brother has been using Subcut, Block E3, Alpha Venus and Alpha Mars and he has noticed a significant change in body shape and has lowered body fat.
We have been loving the podcast as much as we love your supplements and listen to it religiously! In this episode Matt and Jeff discuss the benefits of transdermal methods of delivery of ingredients. Matt & Jeff discuss male pattern baldness as a result of DHT, steroids, microbes, the immune system and your genetics. Subcut and Block E3 are both body shaping serums; however they have very different modes of action. The Block E3 formulation used to be only as a prescription only transdermal aromatase inhibitor estrogen blocker to be used to prevent the conversion of testosterone to estrogen for the prevention and treatment of gynaecomastia and to maximise the results from testosterone replacement therapy.
The Block E3 no longer has those instructions on the label as its intended purpose is as a body shaping serum. For best results use Subcut 3 times daily; after morning and evening shower and again before exercise.
No but we recommend that you combine these powerful tools with a healthy diet and lifestyle.
Ok so after my Doc prescribed me a compounding gel of 200 mg test, .5 mg estradiol, and 8 mg progesterone i did my bloods.
My E2 has been 11 on all 3 of my labs and I'm even taking .5 mg estradiol in my test compounding cream. Can you catch us up with your current stats, medications, lifestyle activities that might be contributing to any conditions you have? My ALT and AST were both 23 just 5 weeks ago, and my AST was 61 and my ALT was 98 on in Dec of 2012.
It's all guess work at this point, Jason, but the indicators are pointing me towards the liver. Consult your doctor if you have a medical condition, if you are or may become pregnant, or if you are nursing. In the female body, progesterone is made from cholesterol and is essential for proper uterine and breast development.
This decrease has been linked to the common side effects associated with menopause; hot flashes, night sweats, and mood swings. Studies show that it also inhibits aromatase, an enzyme that converts androgens (testosterone) into estrogen. For women and men, this action prevents the conversion of testosterone into unhealthy estrogens (estradiol and estrone), and leads to the unhindered production of more good estrogen (estriol) from progesterone, DHEA, and other hormones.
Chi's Newsletter, "The importance of aromatase inhibitors in the treatment of hormone-related conditions has gained momentum in the past few years. In conventional medicine, drug related estrogen control (ie: Tamoxifen) is extremely toxic and has many negative side effects. Chi had to develop was a way of controlling both the formation and utilization of estrogen that had no side effects and no toxicity. The ingredients found in one are natural and can assist in your body’s production of testosterone levels. Made by the adrenal gland, DHEA is known as the “mother of all hormones” and is the precursor to testosterone. This product is not recommended for those who are under the age of 18 or have appropriate levels of testosterone.
Block E3 is an advanced body-shaping serum designed to improve the appearance of the isolated regional fat deposits on the chest of men; and the buttocks and hips of men and women. In women, this causes isolated pockets of fat on the hips, buttocks and thighs and lower abdomen.
Flavones from midnight horror and bladderwrack have very poor oral bioavailability, but can be efficiently absorbed through the skin.
Oestrogen generated in fat cells and breast tissue is predominately used locally and not transported around the body and therefore does not necessarily activate negative feedback mechanisms and triggering subsequent reduction in oestrogen production.
Increasing cAMP in adipose tissue can increase fat burning and metabolism but when used on breast tissue it may increase aromatase activity. Chronic stress can result in increased aromatase activity converting testosterone to estrogen and increased visceral fat around internal organs, as well as reduced detoxification and elimination of estrogen. This tissue can have very poor blood supply and nerve enervation and can basically give up very little free fatty acids, and hormones back into the systemic circulation. Iodine has been used effectively treat fibrocystic breast and iodine is essential for maintaining normal breast tissue architecture and function. Gynaecomastia is commonly seen in athletes using anabolic androgens specifically the aromatizable androgens.
Therefore, they will compete with androgens such as testosterone for aromatase activity and through competitive exclusion; they can bind into aromatase and block it.
Systemic use of aromatase inhibitors can have negative effects on bone health and reduce bone density.
Iodine helps to maintain normal breast tissue architecture and function and low iodine produces a hyper-estrogenic state.
Increased fat deposition in injured skeletal muscle is regulated by sex-specifichormones. Am J Physiol Regul Integr Comp Physiol. Aromatase up-regulation, insulin and raised intracellular oestrogens in men, induce adiposity, metabolic syndrome and prostate disease, via aberrant ER-?  and GPER signalling. Fatty Acyl Esterification and Deesterification of 17? -Estradiol in Human Breast Subcutaneous Adipose Tissue.
Brown kelp modulates endocrine hormones in female sprague-dawley rats and in human luteinized granulosa cells.
In vitro chemopreventive potential of fucophlorethols from the brown alga Fucus vesiculosus L.

He is impressed with the results, so much so thAt he has just purchased T432 & Prototype 8 to add to his stack.
The content is explained in such a simplistic, easy to digest format which we love along with Matt’s dry humour. It works by forcing fat to be released from storage in subcutaneous fatty tissue thereby allowing the fat to be burnt as a source of fuel. Estrogen can inhibit fat burning and lock up fat in subcutaneous fatty tissue storage sites.
Take accurate measurements using tape measure and ideally measure skin folds with callipers before commencing Subcut and you will notice changes to these objective measurements within the first 4 weeks. The directions for use were to apply to the wrist for systemic activity and also use locally to target isolated pockets of estrogen dominant fatty tissue.
The new instructions are to use specifically on the isolated pockets of estrogen dominant fat. Always consult your healthcare practitioner before commencing any new diet and exercise regime. I would discuss the injections with your doctor (as mentioned), which should help with the downstream conversion to E2. You don't have to get too personal, just give us anything pertinent that will help us get a better idea with your program.
Low TSH is sometimes a marker for hyperthyroidism, but you're right, the elevated RT3 might indicate other wise. The liver converts T4 to RT3, and a stressed liver would lead me to think that's the culprit. It also plays a key role in the stress response, maintaining sugar and electrolyte balances and blood pressure regulation. A decrease in progesterone has also been linked to a womana€™s loss of interest in sex, dry and wrinkly skin, water retention and depression. Having medical training in China and having earned a PhD in biochemistry from the Waksman Institute of Microbiology at Rutgers State University, Dr.
Drugs like Tamoxifen and other pharmaceutical estrogen blockers act as E blockers in some tissue (like the breasts) while acting as estrogen in others (like the womb) which is why Tamoxifen users have such a high incidence of Uterine cancer. In that same study, 65% of the women were under 35 years old, demonstrating that this herbal formula is not only limited to postmenopausal women.
Bonded testosterone has no positive impact, but free testosterone does because it attaches to androgen receptors. It’s important to understand that a natural testosterone supplement is not a prescription pharmaceutical hormone, synthesized, or illegal.
Using a natural testosterone supplement when your levels are sufficient can compromise testosterone production. This percutaneous permeation is enhanced when combined with compounds found in piper nigrum.
The more subcutaneous fat cells you have, the more aromatization of testosterone to oestrogen will occur.
Paradoxically using the cAMP inducing SubCut on the adipose tissue of the buttocks and thighs can help to burn the stored fat and reduce oestrogen production from this adipose tissue. Oestrogen fatty acyl esters in adipose tissue surrounding the mammary gland may act as a fatty reservoir for storing oestrogen as fat with the ability to convert back to biologically active oestrogen. Fat cells never sleep and can be making hormones locally and using them locally, either within the single cell or by interacting with neighbouring cells. Iodide-deficiency alters the structure and function of mammary gland alveolar cells and makes them highly sensitive to stimulation by estrogen. Iodine may also have important antioxidant functions in breast tissue and other tissues that concentrate iodine. Many athletes resort to off-label use of tamoxifen and aromatase inhibitors to circumvent this side effect. High doses of anabolic androgens suppress the hypothalamic-pituitary-gonadal axis due to negative feedback, and it may take weeks or months (sometimes longer) for the axis to recover.
More recently researchers have been led to believe it may actually be due to the kelp and its iodine content they consume regularly and use as part of cosmetics and skincare.
Iodine-deficiency alters the structure and function of mammary gland alveolar cells and makes them highly sensitive to stimulation by oestradiol. In vitro evaluation of quercetin cutaneous absorption from topical formulations and its functional stability by antioxidant activity.
Inhibition of aromatase cytochrome P-450 (estrogen synthetase) by derivatives of alpha-naphthoflavone. This has been an area that in the past, just won’t budge even with nutrition and training in check.
I take it you did a clomid protocol because you were shutdown, and the doctor felt he could get your HPTA working again? Furthermore, Myomin's herbal formula is also said to help induce more interferon in the system, which activates natural killer cells. Chi saw, that according to the statistics for the chemotherapy he was helping to create that the outcomes for cancer patients using the Chinese Herbal Medicine he had learned were better than the results of chemotherapy on US patients. Its results are an increased libido, more muscle and less fat, enhanced energy, and a better workout.
Follow the suggested application on the Testro-XL Creme label until you reach your optimum goal.
That contains 3 effective ingredients that work synergistically to inhibit aromatase conversion of testosterone to estrogen and block estrogen activity at the receptor site. Combining subcut and Block E3 together and using them on adipose tissue of buttocks and thighs will have a synergistic effect to help break down fat and remove cellulite, but using that same combination on breast tissue in men and women would have an antagonistic interaction and should definitely be avoided. Furthermore, even after discontinuation, subjects may continue to encounter symptoms of hypogonadism (low libido, erectile dysfunction, and low vitality) until the axis recovers. This action can be beneficial for men with enlarged prostates and for women with uterine fibroids.
Following his conscience, he left the pharmaceutical firms and established his own company to bring to the US chinese herbal formulas that were useful against cancer and the things that create it. Testro-XL is a natural supplement composed of amino acids, protein fragments, peptides, and complex polysaccharides. Next is DIM, which rids the male body of active estrogen by converting it to estrogen metabolites.
This can result in a relative excess of estrogen activity compared to testosterone and subsequent symptoms of estrogen dominance. The metabolites release bonded testosterone from proteins so that they become free testosterone, which produces the results that were mentioned earlier. Widely used in the muscle building community, tribulus terrestris will leave you with more gains, strength, and lean muscle mass. Autoimmune can be interpreted pretty openly, so hopefully the doc is looking a little deeper.

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