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admin | Hormone Supplements | 12.07.2015
Increasing Neck Pain, Low Libido, Weight Gain – Maybe Your Opioid Medication Is to Blame? The sharp rise in the use of opioids for pain management in recent years has also led to an increase in opioid induced androgen deficiency. Results of a study presented at the ENDO 2013: the Endocrine Society 95th Annual Meeting in June suggest that patients with opioid induced androgen deficiency (OPIAD) may be able to reduce both pain and reliance on pain medications through androgen replacement therapy. Testosterone deficiency has also been seen to affect pain response in animal studies with supplementation increasing rats’ capacity to tolerate pain. Androgens are sex hormones, including testosterone, that rely on sufficient levels of gonadotropins (follicle stimulating hormone and luteinizing hormone) to be produced. Low testosterone connected to long-term opioid use in conditions such as neck pain is not always easy to spot. When neck pain affects a person’s ability to exercise, work, and socialize, it may be seen as inevitable that that person will become depressed, overweight, and have issues with their libido and energy levels. Patients are unlikely, and ill-advised to simply cease taking pain medications to see if their symptoms of OPIAD improve. There are some risks of androgen replacement therapy, however, such as prostate disease in men and so patients are not recommended to pursue self-treatment with DHEA or testosterone using store bought products or medications purchased over the internet. Those suffering with neck pain who have found that opioid pain medications are decreasingly effective at managing their pain and who are experiencing symptoms that may indicate opioid induced androgen insufficiency are encouraged to discuss their concerns with their doctor.
However, awareness of this condition remains poor and so many patients with chronic neck pain are suffering with symptoms of low libido, weight gain, fatigue, and depression that may be treatable with androgen replacement therapy.
Men suffering from testosterone deficiency brought on by chronic use of opioids were given a transdermal gel to use for three months in order to boost testosterone, with the results showing that this helped improve pain tolerance compared to placebo. This is the first human study showing similar effects and it may help highlight the increasing prevalence of insufficient androgen production in patients with chronic pain conditions.
Gonadotropins can be adversely affected by opioids, leading to lower levels of sex hormone production and symptoms of low testosterone.
This is because many of the physical and emotional effects of chronic degenerative spine diseases, as well as the after-effects of neck trauma or neck surgery, can appear similar to symptoms of low levels of circulating androgens. That this is not always the case has, however, been illustrated by a study published just last week that found that men taking opioids for back pain were about 50% more likely to fill out a prescription for drugs for erectile dysfunction than men with back pain who were not taking opioid medications. Luckily, blood tests can determine if free and total testosterone levels are abnormally low and patients may then be offered androgen replacement therapy to address the issue. Careful monitoring by a qualified physician needs to be carried out to reduce risks and manage symptoms. This product comes under the names Androxon, Undestor, Restandol and Restinsol in Europe and South America. Patients may feel that their symptoms are a normal response to a traumatic experience or a chronic illness and simply not report them to their physician. Increasingly, physicians are encouraged to monitor patients taking opioids long-term for signs of OPIAD and to work with patients to prevent severe symptoms arising.
The use of androgen replacement therapy has not been well studied in women and benefits may be marginal with some potential side effects including hirsutism, acne, polycythaemia, increased high-density lipoproteins and risk of cardiovascular disease, and endometrial hyperplasia.
Clitoral stimulation in postmenopausal women with sexual dysfunction: A pilot randomized study with hormone therapy.
Many physicians may lack knowledge of OPIAD and, unfortunately, dismiss patients’ symptoms as a typical set of effects connected to chronic ill health.


Women with OPIAD will likely be prescribed dehydroepiandrosterone (DHEA) while men will be prescribed testosterone to restore functional sex hormone levels and, according to this latest research, this may also help improve pain tolerance and allow them to reduce their use of opioids. However, some benefits that have been reported include: improved libido, increasing initiation and enjoyment of sex, and enhanced ability to reach orgasm. Try These Five Foods That Can Help You SleepNatural Neck Pain Relief Within 30 Minutes – How Effective is Celadrin Cream for Arthritis and Myofascial Neck Pain Syndrome? Patients in this latest study also reported improvements in emotional symptoms affecting their daily quality of life. With Propionate, androgenic side effects seem somewhat less pronounced than with the other Testosterones, probably due to the fact that blood levels do not build up as high. Clenbuterol is a selective beta-2 agonist that is used to stimulate the beta-receptors in fat and muscle tissue in the body. Clenbuterol exhibits most of its effects on the stimulation of both type 2 and 3 beta-receptors.
Virigen is actually contained in a natural ester base, one, which is very easy on the body.
This product's advantageous properties are similar to other testosterones in that it promotes rapid strength and weight gains. Virigen does not seem to exhibit the degree of LH and FSH suppression that is seen with other testosterones and androgens. Users will usually tailor their dosage individually, depending on results and side effects, but somewhere in the range of 2-8 tablets per day is most common. All in all, Virigen seems to yield gains similar to other testosterone esters, while being safer to administer. For fat loss, Clenbuterol seems to stay effective for 3-6 weeks, then it's thermogenic properties seem to subside.
If it were around in the United States, it's popularity would be comparable to oral Dianabol. Clenbuterol is attractive for its pronounced thermogenic effects as well as mild anabolic properties.
Virigen is a safe oral steroid that does not suppress gonadotrophins.It is absorbed through the small intestine into the lymphatic system, no burden to the liver it is a natural ester added to a synthetic derivative which will nor change liver enzymes. A number of medical reviews have cited its outstanding potential to promote muscle gains as well as fat loss and weight loss. No testicular shrinkage, no reduction on in spermatogenesis will occur with reasonable dosages. There have been an increasing number of American bodybuilders that are experimenting with this drug. Cholesterol triglycerides and total lipids tend to be reduced with long term use of Virigen as opposed to elevated with most oral steroids. Many athletes who use Clenbuterol claim that it promotes dramatic strength increases and a very noticeable reduction in body fat and weight loss. Some athletes claim that they enjoyed significant gains in muscle mass while using Clenbuterol. This version of testosterone is based in oil and is sealed in a capsule to be taken orally.
According to the manufacturer, this method bypasses the liver and enters the body as a fat through the lymphatic system.


It is not banned by any athletic committee; thus, numerous professional bodybuilders have used it for the last month of contest preparation. In theory this seems quite interesting, however, athletes find Organon's claims don't hold up well. The reason although it is fairly anabolic, and it promotes the burning of fatty acids through brown fat burning.
Dosages are normally between 20-120 mcg for bodybuilders that use this.This drug becomes ineffective for its anabolic properties after 18 successive days of use. Generally, steroid users experienced with any strong anabolics will be disappointed with Virigen's results.
Although there is quite a bit of medical literature showing clenbuterol's potential as a bodybuilding drug, most of these studies have been done on animals; very little human data on this issue is available. Therefore, in assessing its effects in humans, you have to rely primarily on empirical and anecdotal evidence. However, with the recent wide scale use of clenbuterol by athletes, we can now gather quite a bit of evidence on what the real world effects of Clenbuterol are in weight trainers.
To say that Clenbuterol use is rampant in bodybuilding right now would be an understatement.
I personally know a number of pro football players, foreign Olympic athletes, and professional bodybuilders who are using clenbuterol. In addition, I have received feedback from at least 200 other athletes who have experimented with this novel compound. Generally, the feedback from clenbuterol users is that the drug produces dramatic body composition alterations. One Canadian strength coach compared the results he has seen in athletes using Clenbuterol to what one might experience while using a stack of Anavar and Halotestin. Within weeks of beginning Clenbuterol therapy, many athletes notice a significant strength increase and a dramatic reduction in body fat.
The results that occur secondary to Clenbuterol administration seem to occur equally in men and women as well as young and old. The trick of using Clenbuterol successfully seems to be avoiding receptor downgrade which occurs rapidly with the use of this beta agonist. In fact, one clinical study showed downgrade at receptor as much as 50% experienced after using Clenbuterol for as little as 18 days consecutively. The same study showed that attenuation can be avoided if Clenbuterol is taken in a '2 day on' then '2 day off' pattern.
Athletes using Clenbuterol in this manner have reported much greater results than those who use the product continualy which seems to support the theory that attenuation can be at least partially avoided by staggering the dosage.
Athletes have also made a habit of cycling Clenbuterol in an effort to minimize side effects as well as prevent receptor downgrade.
It allows people to keep eating large amounts of foot without adding excess adipose tissue (fat). Alternative To Steroids: Clenbuterol has a mild steroid like affect and can be used by athletes that do not use anabolic steroids, to increase lean body mass.



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