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Serotonin reuptake inhibitor, signs of a nervous breakdown symptoms - Review

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Selective serotonin reuptake inhibitors (SSRIs) are medications widely prescribed for the treatment of depression, obsessive-compulsive disorder, bulimia, anorexia nervosa, panic disorder, and social phobia. Nerve cells normally recycle serotonin by reabsorbing it, and the SSRIs work by inhibiting this re-uptake of serotonin. Serotonin is one of several chemicals called neurotransmitters; each nerve cell generally uses one of these chemicals to pass on messages on other nerve cells.

David Healy, Professor of Psychiatry at the Hergest psychiatric unit in North Wales, points to a misconception that lowered serotonin levels in depression are an established fact, which he describes as “the marketing of a myth.” The serotonin reuptake inhibiting (SSRI) group of drugs came on stream in the late 1980s, nearly two decades after first being mooted, writes Healy.
When not enough serotonin is released by the first nerve cell, the message won't get through the next nerve cell: this is one of the changes that appears to be important in causing depression. SSRIs work selectively on serotonin and have the power to mildly influence mood, outlook, and behavior.

Despite being weaker than old-style tricyclic antidepressants, they grew in popularity because it was believed they restored serotonin levels back to normal, “a notion that later transmuted into the idea that they remedied a chemical imbalance,” said David Healy, head of psychiatry at the Hergest psychiatric unit in Bangor, North Wales.

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