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18.11.2014

Manic depressive symptoms mayo clinic, cure tinnitus with meditation - .

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By genotyping patients with bipolar disorder and using state-of-the-art imaging technology to evaluate drug effects, Mayo Clinic psychiatry researchers are learning more about the genetics of the disorder and how to better treat it.
Bipolar Type I disorder involves manic or mixed episodes lasting at least seven days that can be dangerous and require hospital care.
Mayo Clinic psychiatry researchers are investigating ways to end the roller coaster ride, or at least to eliminate some of its rushes and surges.
Mayo Clinic is participating in an effort to rewrite accepted diagnostic criteria for bipolar disorder. The biobank is a collaborative effort with the University of Minnesota, the Lindner Center of Hope in Cincinnati, Ohio, and all Mayo Clinic campuses.
Frye and colleagues are performing extensive blood tests, molecular testing and brain scans of patients with bipolar disorder to build the Mayo Clinic Individualized Medicine Biobank for Bipolar Disorder. In these studies, the control group will come from the 20,000 participants in the Mayo Clinic Biobank.


Some of our earlier work had characterized bipolar depression as having an increase in glutamate in the anterior cingulate, which is a brain region implicated or associated with depression. Frye is now recruiting for a five-year clinical trial to evaluate the effectiveness of lamotrigine treatment for bipolar disorder. The biological and clinical data collected in the biobank is intended as a resource for the bipolar research community to facilitate research leading to more accurate diagnosis, individualized drug therapies and increased knowledge about risk factors. Samples are usually collected by Mayo's Clinical Research Unit and stored in the Biospecimens Accessioning and Processing (BAP) Shared Resource core facility. In the case of antidepressant-induced mania, they are looking for patients who became manic while on Prozac and compare them with patients who were on the drug for the same time and did not become manic.
Furthermore, we saw a change in glutamine that was linked to clinical remission of depressive symptoms in the presence of lamotrigine." This, he thought, warranted further investigation. In his book, "Psychiatric Pharmacogenomics," he cites a case study in which both parents and their twin sons were diagnosed with depression.


In a collaborative study, he and other researchers found that half of 529 patients (mean age of 42) had their first symptoms before age 13 or in their adolescence years (JClinPsy 2010). And some antidepressants, while effective in one individual, can trigger new rounds of uncontrollable mania in another. The trial, funded by the National Institutes of Health (NIH), studies glutamate and glutamine concentrations in brain regions implicated in bipolar disorder, to evaluate their effect on clinical remission.



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