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Mammalian oocytes go through a long and complex developmental process while acquiring the competencies that are required for fertilization and embryogenesis.


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Disruption of GSK3 signalling adversely affects brain development and is associated with several neurodevelopmental disorders. Whereas self-organization of microtubules and motor proteins direct meiotic spindle assembly for achieving genome reduction, actin filaments are instrumental for spindle positioning and the establishment of oocyte polarity needed for extrusion of polar bodies.


Here, we discuss the mechanisms by which GSK3 activity is regulated in the nervous system and provide an overview of the recent advances in the understanding of how GSK3 signalling controls neurogenesis, neuronal polarization and axon growth during brain development.



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