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BACKGROUND: Serum testosterone concentrations decrease as men age, but benefits of raising testosterone levels in older men have not been established.
METHODS: We assigned 790 men 65 years of age or older with a serum testosterone concentration of less than 275 ng per deciliter and symptoms suggesting hypoandrogenism to receive either testosterone gel or placebo gel for 1 year. RESULTS: Testosterone treatment increased serum testosterone levels to the mid-normal range for men 19 to 40 years of age. CONCLUSIONS: In symptomatic men 65 years of age or older, raising testosterone concentrations for 1 year from moderately low to the mid-normal range for men 19 to 40 years of age had a moderate benefit with respect to sexual function and some benefit with respect to mood and depressive symptoms but no benefit with respect to vitality or walking distance. Testosterone replacement therapy my restore sexual function and libido, may improve protein and fat metabolism, prevent bone loss and result in an increase in energy levels and an improved sense of well being. The diagnosis of low testosterone is based on taking into account the symptoms a patient has and the results of testosterone blood test. Testosterone exists in a number of forms within the blood stream - some active and some inactive. Testosterone can be administered as a gel that is absorbed through the skin (tostran gel, testogel, testim gel), an intramuscular injection given every 10-14 weeks (nebido), a buccal adhesive tablet (striant), or as oral tablet (restandol). Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Testosterone is an androgen, or sex-related hormone, produced in the ovaries, adrenal glands, and fat cells.
Women should consider testosterone therapy only if they have significantly decreased sexual desire, and if other possible causes have been ruled out, says Larissa Bresler, MD, an assistant professor in the department of urology at Loyola University Stritch School of Medicine in Chicago. Some evidence has pointed to the idea that testosterone replacement could increase the risk for cardiovascular events such as heart attacks, especially in frail older men, but a March 2015 study in the journal Endocrine found that it did not. A woman on testosterone therapy may notice unwanted hair growth on her face and chin, oily skin and acne, and male pattern baldness.
Before you start any hormone therapy, have your annual mammogram and gynecological exam to be screened for cancer.
From our SponsorsEveryday Solutions are created by Everyday Health on behalf of our sponsors. Each man participated in one or more of three trials — the Sexual Function Trial, the Physical Function Trial, and the Vitality Trial. The number of participants was too few to draw conclusions about the risks of testosterone treatment. There is uncertainty about the interpretation of testosterone blood levels for the following reasons. In an ideal world we would wish to measure only the active component but to date this has not proved possible.

In these cases if a patient has symptoms suggestive of a low testosterone level treatment with testosterone replacement can be considered and the clinical response evaluated.
Androgens play a role in more than 200 functions in women, according to the National Women's Health Resource Center, among them, sexual arousal.
They include low energy, low sex drive, and general fatigue, says Jay Simhan, MD, director of urologic trauma, reconstruction, and prosthetics for the Urologic Institute of Southeastern Pennsylvania, and the Einstein Healthcare Network in Philadelphia.
Low testosterone could result in decreased interest in having sex because the hormone enhances vaginal blood flow and lubrication, according to the American Society for Reproductive Medicine.
Nonetheless, earlier this year the FDA decided to require testosterone drug makers to tell their users that testosterone therapy could increase the risk of heart attack and stroke, and may not increase hormone levels that dip because of age. Testosterone is ultimately converted into female hormones, and "unbalanced female hormone replacement may influence the risk for gynecological cancers,” Bresler says.
One reason for this uncertainty is that there are no FDA-approved testosterone formulations for women.
And only use testosterone therapy under the guidance of a medical professional who can monitor your cholesterol, blood pressure, and other health conditions. To be sure if low-T therapy is right for you, work with a doctor who specializes in sexual medicine, Simhan advises. View all.ConnectDon't miss out on breaking news, live chats, lively debates, and inspiring stories.
The primary outcome of each of the individual trials was also evaluated in all participants. The percentage of men who had an increase of at least 50 m in the 6-minute walking distance did not differ significantly between the two study groups in the Physical Function Trial but did differ significantly when men in all three trials were included (20.5% of men who received testosterone vs. The total level of testosterone is a guide to the active level but can be unreliable in certain circumstances. Testosterone allows men to grow facial hair, build strong muscles, and develop a deep voice, according to the Hormone Health Network. As in men, low testosterone in women, also referred to as low T, may result in decreased libido.
Other symptoms of low T are erectile dysfunction, depression, inability to concentrate, reduced muscle mass, and osteoporosis. As it does in men, testosterone also plays a role in maintaining bone and muscle mass in women. Testosterone also can cause overproduction of red blood cells, which puts you at risk for blood clots.
The agency is also requiring pharmaceutical companies to conduct long-term clinical trials to identify overall health effects of therapeutic testosterone.

But that doesn’t prevent doctors from prescribing the products approved for use in men to women. This is usually a urologist or a gynecologist, but ask about your doctor's areas of expertise to be sure.
Join the conversation!Free NewslettersPersonalized tips and information to get and stay healthier every day. Any medical or health advice provided and hosted on this site will only be given by medically trained and qualified professionals unless a clear statement is made that the advice offered is from a non-medically qualified individual or organisation.
On the other end of the spectrum, high testosterone in women is one of the symptoms of polycystic ovary syndrome (PCOS), a common endocrine disorder. Which means that low testosterone levels could result in women's bodies becoming doughy and the development of osteoporosis. Nagler says that a man should have his levels tested at least twice, particularly in the morning, when levels peak. Some doctors use testosterone therapy for vulva pain, "but that's not something approved by any professional society's guidelines," she adds. All of these can help raise your testosterone level, and you should try them before taking hormone therapy, Bresler says.
You will also what to inquire about any financial or other interests he may have in prescribing low testosterone therapy. Testosterone had no significant benefit with respect to vitality, as assessed by the Functional Assessment of Chronic Illness Therapy–Fatigue scale, but men who received testosterone reported slightly better mood and lower severity of depressive symptoms than those who received placebo.
Where appropriate, information contained on this site will be supported by clear references to source data and, where possible, have specific HTML links to that data. Some men lose about 10 percent of their testosterone every decade once they reach their 30s.
Women’s testosterone levels decline significantly leading up to menopause, and continue to do so during and after menopause. The Food and Drug Administration (FDA) states that testosterone therapy should not be used in men if aging is the only apparent cause of low levels.
As testosterone levels drop, you can experience changes in the way you feel and think, and there are some health implications, too. Continue on to find out how testosterone affects your health, and what you can do if your level falls.

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