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Survival rate in mouth cancer,comprar casa con tax id 2014,survivalcraft multiplayer android download,psychological issues with erectile dysfunction - PDF Review

A leading professor of oral medicine has expressed concern about the lack of improvement in UK mouth cancer survival rates compared to other cancers. Professor Saman Warnakulasuriya, Professor of Oral Medicine at King's College London, expressed his concerns at the launch of November's Mouth Cancer Action Month held at the House of Commons.
During his speech at the House of Commons, Professor Warnakulasuriya said: "The magnitude of the problem of mouth cancer in the UK is growing.
Chief Executive of the British Dental Health Foundation, Dr Nigel Carter, said: "Early detection is particularly important to survive mouth cancer and recognising the warning signs is something that everyone should be familiar with. Table: Percentage change in the European age-standardised mortality rates, by sex, major cancers, UK, 1999-2008.
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Itchy scalp and female hair loss - balding blog, I have the same condition as the two previous comments. Chief executive of the British Dental Health Foundation, Dr Nigel Carter, said, “Early detection is particularly important to survive mouth cancer and recognising the warning signs is something that everyone should be familiar with. To describe 5 and 10-year survival rates in patients with cancer of the lip, mouth and pharynx at a referral center in Florianopolis, Santa Catarina, Brazil.
Cancer of lip, mouth and pharynx is a serious and increasing public health problem in many parts of the globe. The main factors associated with cancer of the lip, mouth and pharynx are the use of tobacco and alcohol and exposure to UVA radiation (lip cancer)3. Cancer of the lip, mouth and pharynx may cause important functional and esthetic changes, which requires a multidisciplinary approach for treatment5. Approximately a third of the patients develop malnutrition, which is not exclusively caused by tumor growth, but also by associated factors such as the aerodigestive tract location of the tumor and the sequelae of surgical treatment7. Cancer originates mostly in the mucosa, where squamous cell carcinoma is the commonest and usually developed from premalignant lesions as leukoplakia and erythroleukoplakia3.
This was a retrospective cohort study14 performed with data from patients with cancer of the lip, mouth and pharynx (ICD-O C00 to C06, C09 to C10 and C12 to C14), who were diagnosed between January 1st and December 31st, 2001, treated at the Center for Oncologic Research (CEPON) of FlorianA?polis and registered at the Hospital Cancer Registry System15 of this institution. These registries are systematic sources of information on malignant neoplasia diagnosed and treated at the hospital they were managed, following criteria established by the Brazilian National Institute of Cancer (INCA). Data regarding death, such as date and cause, were gathered from the Mortality Information System of the Brazilian Ministry of Health, based on death certificates. In order to carry out patient follow-up, the probabilistic relationship method of registration was used16, relating the Hospital Cancer Registry System database with Mortality Information System. Survival was calculated as the interval between date of diagnosis (biopsy or surgery) from the Hospitalar Cancer Registry database and date of death or last date of follow-up. The estimation of the effect of the independent variables was performed based on the semi-parametric model of proportional risks, Cox model, which estimates proportionalities of risks along the period of observation17.
In the period studied, 141 people had a diagnosis of cancer of the lip, mouth and other pharynx.
The survival rates and factors were analyzed together: lip, mouth and other pharynx, because the groups were very small, and they did not differ statistically among them. This study aimed at estimating survival rates at five and ten years from a diagnosis of cancer of the lip, mouth and pharynx. Tobacco smoking is the main risk factor for cancer of the lip, mouth and pharynx, especially regarding long-term heavy smoking (20 or more cigarettes a day) or users of black tobacco with a high tar content21.
Alcohol intake also increases the risk of developing this type of cancer - a heavy drinker (a weekly intake of more than 300 mL) has a risk 10 times higher than non-drinkers or those who drink sporadically. The information reported in this study regarding age at diagnosis does not corroborate the findings of another study27, which reported a decrease in survival with an age increase. Regarding ethnicity, both diagnosis and death rates were higher in white individuals, although this did not reach statistical significance. Regarding previous diagnosis and treatment, the death rates found were similar in the three categories.
On the other hand, the clinical stage at diagnosis was an independent factor associated with survival, both at five and ten years of follow-up.
The most effective way to improve the prognosis of patients with cancer of the lip, mouth and pharynx is the prevention of risk factors and early diagnosis, since early treatment results in a high percentage of resolution.
Health professionals have the obligation to be prepared to recognize suspicious lesions and carry out a diagnostic biopsy or, at least, refer the patient.
The strong points of this study were the reports of data from official sources, as established by INCA, as well as the inclusion of the follow-up time of ten years, which permitted an insight into survival rates over a long period of time and is not commonly encountered in Brazilian studies. A This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. If your username or email address exist in our database, you will receive instructions how to reset your password. However, early detection of the disease can improve five year survival rates to 90 per cent.
Over the past ten years the mortality rate for all cancers has fallen by nine per cent - around 12 per cent for men and eight per cent for women1.


Over the past 10 years, the mortality rate for all cancers has fallen by nine per cent – around 12 per cent for men and eight per cent for women. Methods: Retrospective cohort study using data from patients diagnosed between January 1st and December 31st, 2001, with follow-up until December 31st, 2011.
Advanced stage was an independent risk factor for death due to cancer of the lip, mouth and pharynx in both periods analyzed. The latest global estimates indicated that about 300 thousand new cases and 145.000 deaths occurred in 20121. The clinical background may include persistent pain, dyspnea, dysphagia, odynophagia, xerostomia, voice changes, weight loss, rigidity of tissues and decrease or loss of work capacity. Malnutrition is associated to higher rates of post-operative complications, poor response to treatment and higher risk of disease recurrence8. Periodic examinations by health professionals are recommended, thus there is possibility to referral for diagnostic investigation of premalignant suspected lesions, and not present major difficulties for trained professionals since the groups at highest risks are known and the site is easy to access for clinical examination and biopsy9. Furthermore, survival data is useful to assess the general impact of disease on public health programs, since they estimate the effectiveness of health systems which depend upon the quality and availability of healthcare. Disease stage at diagnosis affects survival rates; for mouth, the survival rate at stage I is 70%, whereas for stage IV, it drops to 30%13.
This reality highlights the need for early diagnosis to increase treatment effectiveness in order to improve outcome12. The knowledge of cancer survival rates may contribute towards monitoring treatment outcome in order to increase population survival as well as to identify prognostic factors.
The cancer cases of parothid gland C07 (n = 5) and nasopharynx C11 (n = 17) were excluded from the sample.
This database was made available by the Health Secretariat of Santa Catarina and analyzed between 2001 and 2011.
The maximum follow-up was ten years - patients not found on Mortality Information System or who did not have a date of death on Hospitalar Cancer Registry were censored at the last follow-up date. The probability of survival up to the specified date was estimated, considering that survival up to each studied time was independent from the survival up to other times. The high incidence, prevalence and mortality rates observed as well as the low survival18 reported in some studies warranted the importance of the present study. The synergistic effect between tobacco and alcohol results in a 30-fold increase in the risk of developing the disease18.
A study performed by Rodriguez and Adelstein19 reported a negative impact on survival with the continued use of tobacco after treatment, thus suggesting that smoking cessation may improve survival. This risk factor seems to be related to exposure to an intermediate metabolite of ethanol, acetaldehyde, which is a known carcinogen20. There is evidence that exposure to tobacco is higher in men than in women26, and that women notice the symptoms of the disease more easily than men, which may lead them to seek medical assistance earlier23, thus resulting in earlier diagnosis and improved survival. The authors pointed out that older patients at the time of diagnosis may die as a result of complications of treatment, as they may be unable to tolerate the aggressiveness of the therapeutic approach27. The results of this study are therefore inconclusive and one must take into account the data in the literature, which shows death rates higher in individuals of mixed ethnic background23.
Although this study has been carried out in a referral center, it is worth to highlight that nearly 10% of the subjects arrived with no previous diagnosis and consequently with no treatment. This finding corroborates that of a different study, which described a higher prevalence of stage IV disease associated with a decrease in survival for all sites13.
The main causes of delayed diagnosis are lack of information and symptom neglect by the patients, as well as health professional failure at routinely screening patients22. Therefore, periodic visits to the dentist are paramount to increase detection of early lesions and to monitor changes. However, the limitations must be taken into consideration when interpreting the results; one of them was the dependence on information stored on the database system used, which did not provide some important data, such as the presence of other relevant risk factors. Advanced stage at diagnosis was an independent risk factor of death due to cancer of the lip, mouth and pharynx in both periods analyzed. Galbiatti ALS, Padovani-Junior JA, ManA­glia JV, Rodrigues CDS, Pavarino EC, Goloni-Bertollo EM. Pruegsanusak K, Peeravut S, Leelamanit V, Sinkijcharoenchai W, Jongsatitpaiboon J, Phungrassami T, et al.
However, over the same period, the survival rate for men suffering from mouth cancers has only improved by 5.5 per cent. In Brazil, the Southern and Southeastern regions have the highest incidences in the country. Sex, ethnicity, level of education, previous diagnosis and treatment, as well as age, did not show significant association. Occupational risk factors have also been cited in literature, such as exposure to toxic agents or solar radiation during the labor.
The functions often compromised are related to the anatomo-physiology of the head and neck6. Careful visual examination of the oral mucosa by a dentist with adequate illumination may result in early detection of the disease. Survival knowledge is essential for planning and managing disease in each region as well as to help monitoring and controlling prognostic factors in the population12.


Therefore, the aim of this study was to describe the survival rates at 5 and 10-year follow-up periods for patients with cancer of the lip, mouth and pharynx, who were treated at a referral center in FlorianA?polis, capital of the State of Santa Catarina, Southern region of Brazil.
The only reported cancer case of other lip, mouth and pharynx sites C14 (n = 1) were maintained in the sample.
The association rules were determined between the two databases, using variables from each of them. In order to compare the stratified survival curves, log-rank test was used, which compared values observed and the expected values for each stratum, considering the null hypothesis that the risk was the same for all strata17. All analyses were carried out for 5 and 10 years of follow-up using the Stata SE 9.0 software. The data on death incidence as well as on 5 and 10-year survival rates by specific sites are described in Table 1. According to Galbiatti et al.22, there is a significant reduction in the risk of developing the disease when the patient quits smoking. However, in this study, no significant difference was observed either at five or ten years of follow-up. Regarding level of education, no significant difference was found at five or ten years of follow-up.
The literature shows that the most frequently performed treatment for cancer of the lip, mouth and pharynx is radiotherapy; however, for patients with loco-regional disease, the use of radiotherapy did not alter survival27. The reason for a low rate of early diagnosis is related to a low level of preparation of dentists, as other health professionals, to actively screen and recognize potentially malignant oral lesions, which could be diagnosed and treated before malignant transformation10. Furthermore, the dental professional must instruct their patients to examine their own mouth, aiming at detecting lesions as early as possible10. Furthermore, the database used for this study generated a considerably high number of cases, for which no information on smoking or alcohol intake was available, which led to the exclusion of those variables. Nutrient-based dietary patterns and the risk of head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology consortium. Qualidade de vida das pessoas acometidas por cA?ncer no trato aerodigestivo superior em um Hospital UniversitA?rio. Survival and prognostic factors of different sites of head and neck cancer: an analysis from Thailand.
25 Year survival outcomes for squamous cell carcinomas of the head and neck: Population-based outcomes from a Canadian province. Reclink: an application for database linkage implementing the probabilistic record linkage method. Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Head and neck cancer in a developing country: a population-based perspective across 8 years.
Changes in survival in head and neck cancers in the late 20th and early 21st century: a period analysis. The male population carries the highest risk of developing this type of cancer; in Brazil, for each one new case in female population there are three cases in male population2. Speech, swallowing, phonation and appearance are adversely affected by both the disease and its treatment; some treatment options are associated with relevant dysphonia, dysphagia and facial disfiguring, with loss of function and a considerable impact on social relationships6.
In addition, palpation of the adjacent structures, such as the neck, submandibular regions and jaw bones is of paramount importance.
The Mortality Information System variables were death certificate number, patient name, date of birth, date of death, cause of death and town of residence. The variable age showed an increase of death risk of 2% every year from diagnosis, however statistical significance was missed in the adjusted analysis. Such lack of preparation makes health professionals underprepared to establish an earlier diagnosis. Hopefully, higher levels of awareness to the problem and appropriately trained health professionals, especially dentists, both at the undergraduate and the following professional development levels, may cause an impact on the rates of early diagnosis and, consequently, on higher survival rates9. Another aspect to be considered is the difficulty imposed by the need of including cancer cases with different topographies in this survival study, in order to compose a minimum sample for analysis.
Overall, mouth cancer survival rates have only improved by 2.3 per cent between 1999 and 2008. The Southern and Southeastern Brazilian regions have the highest incidences in the country2. Evidence shows that high intake of fiber, fruits and vegetables reduce the risk of head and neck cancer, as well as the poor intake of red meat4. The diagnosis of small early lesions is fundamental for good prognosis10, which is dictated by tumor site, size, lymph node involvement and age of the patient11. The Hospital Cancer Registry variables were patient record number, patient name, date of birth and town of residence. This limitation, in turn, affects patient referral to the appropriate services, which further complicates treatment and reduces the chances of a cure10.



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