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Cancer-causing agents (carcinogens) in the urine may lead to the development of bladder cancer.
Cystoscopy - Local anesthesia is administered and a cystoscope (thin, telescope-like tube with a tiny camera attached) is inserted into the bladder through the urethra to allow the physician to detect abnormalities.
IVU or intravenous urography is a series of X-rays taken of the kidney, ureter and bladder after injection of a dye into the bloodstream. CT Urography is a series of CT scan X-rays of the kidney, ureter and bladder taken after injection of a dye into the bloodstream. Cigarette smoking contributes to more than 50% of cases, and smoking cigars or pipes also increases the risk.

Occupational risk factors include recurrent exposure to antineoplastic drugs (used in chemotherapy), hair dye and aniline(a chemical used in medical and industrial dyes). Hematuria may be visible to the naked eye (gross) or visible only under a microscope (microscopic) . The aim is to diagnose tumours that may arise from the internal mucosal lining of the whole urinary tract. This very detailed study not only allows tumours arising from the internal mucosal lining to be diagnosed, it can also detect solid tumours in the kidney and bladder. If the cancer spreads into the muscle wall of the bladder, it is called invasive bladder cancer.

Workers at increased risk include medical workers, hairdressers, machinists, printers, painters, truck drivers and workers in rubber, chemical, textile, metal, and leather industries.
If tumour is detected, the patient goes for transurethral resection of bladder tumour (TURBT).
Bladder cancer  has the ability to spread to other body parts including the lungs, bones, and liver.

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