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The first sign of bedbugs may be red, itchy bites on the skin, usually on the arms or shoulders. It is an anaplastic melanoma consisting of cells derived from melanoblasts but not forming melanin.
Bedbugs tend to leave straight rows of bites, unlike some other insects that leave bites here and there.

But itching from the bites can be so bad that some people will scratch enough to cause breaks in the skin that get infected easily. The tumor presents as a smooth to slightly scaly, round to oval, raised, firm papule or nodule, ranging in color from pink-tan to purplish red, often with surface telangiectasia.

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