Familial advanced sleep-phase syndrome (FASPS)FASPS is a autosomal dominant human behavioural disorder that causes early sleep times, early morning awakening and a short circadian period53. The first sign of DSPS in adolescents can be easily dismissed as normal childhood behavior: namely the desire to stay up later.
While it would be comforting to those suffering from DSPS if the world would make accommodations for them, when dealing with institutions like public school it is nearly impossible. In addition, maintaining a strict bed time and wake time, helps manage hormonal disruptions to which people with DSPS are very prone.
Fortunately, many who suffer from Delayed Sleep Phase Syndrome grow out of it by early adulthood. Delayed sleep phase syndrome is caused by the abnormal delay of the circadian clock in the body. In addition to the abnormal delay in sleep timings, patients suffering with delayed sleep phase syndrome often show a delay in circadian rhythm plasma melatonin, urinary melatonin metabolite excretion and core body temperatures. The repeated mismatch of normal scheduling of sleeping hours often affect patient in various ways. Environmental conditions can also affect your sleep and you can be a victim of sleep disorder.
It’s always advised to have a good sleep hygiene that is fixing your sleeping time and maintain it for a lifetime.
Genetic analysis in one family affected by FASPS identified a single amino-acid missense mutation in the human period-2 (PER2) gene as the cause of that sleep disorder variation54. Many teenagers would love to stay up until four am and wake up at noon, but for people afflicted with DSPS there is little choice.

Indeed, while adults can engineer their lives so they can stay up all night and sleep during the day, it is not the preferred circumstance for most people.
Sleep timing and wake-up times are significantly affected or delayed in contrast to the normal sleeping and wake-up hours. Most people take their good nights sleep for granted, but for others their sleep is riddled with problems.
However, unless accompanied by another sleep disorder people with DSPS will be able to sleep soundly and wake up refreshed, albeit at times that do not conform to societal standards.
Their own hormonal and body chemistries have dictated a sleep scheduled that is counter to the norm.
For example, if a child is prone to falling asleep at four am and waking at noon, they should try going to sleep the first night at three-thirty and then waking at eleven-thirty. Researchers are seeking a definitive cure for DSPS, but at the moment it is still considered incurable. In most of the cases people suffering with this often are deprived of their sleep at night and usually they go to sleep in the early morning and then continue with their sleep till afternoon or late evening. This is often termed as the social jet lag which disturbs sleep phase for quite a long time and becomes a habit. If a person works mostly in dark and has a little exposure to light it can also cause delayed sleep phase syndrome. Make your room environment cool, calm and composed so that it doesn’t disturb your sleep and help you sleep better. They are characterized as “night-owls” as they totally reflect the pattern on how an owl sleep at daytime and wake-up all night.

Persons suffering with DSPS often complain of headache, loss of appetite, depressed mood and loss of concentration. Sleeping pill can be taken but it not advised on a regular basis because of its various side effects. Symptoms and treatment of this syndrome mostly affect adolescents, but can also be found in some younger children. A polymorphism in the human PER3 gene (V647G) has been linked to the pathogenesis of DSPS111. In most cases people often find it difficult to cope up with their sleep and become obvious victim of laziness and lose their concentration. It is now most common in adolescents and more than 7% adolescents approximately suffer from this syndrome. Therefore, this polymorphism might alter the CKI-dependent phosphorylation of human PER3.Another polymorphism that is present in the normal population but absent in individuals with DSPS is in human CKI.
This variant (S408N) is significantly less common in DSPS patients than in control individuals. Social late night sleeping plays a very important role because if it becomes habit then it’s very difficult to overcome it. The protective function is postulated to arise from an alteration in CKI activity, as it eliminates a putative autophosphorylation site in the autoinhibitory domain of the kinase and leads to a more active kinase, at least in vitro112.The image shows theoretical recordings of activity rhythms corresponding to individuals affected by FASPS, DSPS or normal people.

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