Tryptophan is one of the 22 different naturally occurring basic units of proteins (amino acids) found in the human body. Fortunately enough, it is a part of many food items consumed almost daily including, nuts, eggs, some dairy products, soybeans, walnuts and oats. Consequently, many people have started using tryptophan as a nootropic supplement for increasing and sustaining levels of tryptophan inside their bodies. A hormone, melatonin, is responsible for regular and healthy sleep patterns and also needs tryptophan as a precursor.
Tryptophan is now available in the market as a dietary supplement to regulate levels of tryptophan in blood. Resorting to supplements can be very beneficial for the body and prevent many deficiency issues. Tryptophan supplements are being used widely as anti-depressants with minimal side effects. The dosage of the supplements depends on the specific purpose tryptophan is being consumed for and should be taken after consulting with a doctor.
Tryptophan supplements can really help people who want to improve on their anxieties, depression and sleep patterns. Our products have not been evaluated by the FDA and are not intended to treat, diagnose or cure any disease.
Indeed, in addition to the metabolic pathway leading to serotonin, tryptophan is used in protein synthesis and it is transformed by hepatic tryptophan pyrrolase, generally called tryptophan 2-3-dioxygenase and by indolaleamine-2,3-dioxygenase, into N-formylkynurenine then into kynurenine, precursor of xanthurenic acid and nicotinic acid. Hydroxylation in 5-hydroxytryptophan catalyzed by tryptophan hydroxylase, which is the rate limiting enzyme of the synthesis.
In the brain, serotonin biosynthesis depends on the quantity of tryptophan which crosses the blood-brain barrier.

Transformation of serotonin into melatonin, which should not be regarded as a degradation pathway because melatonin is also active, is carried out primarily in the pineal gland.
Methylation of the OH group by 5- hydroxyindole-O-methyltransferase catalyzing the transfer of a methyl group from S-adenosyl-methionine to obtain acetyl-5-methoxytryptamine or melatonin. The concentration of melatonin in the pineal gland presents circadian variations: it follows the variations of N-acetyl transferase activity, increasing during the night and decreasing during the day, darkness and light playing a regulatory role via catecholamines. The half-life of serotonin is long in platelets and intestine, and very short, a few minutes, in the brain. The amount of tryptophan in one’s body directly affects a person’s mood and leads to healthy sleep.
Tryptophan further plays an important role as a precursor for many other chemical substances needed for essential bodily functions like, Niacin – a Vitamin B, and Auxin, a phytohormone. Tryptophan supplements help to modulate our social actions, control our appetites and reduce anxiety as well as depression in a person. A research study done in 2010 showed that tryptophan can cause the prevention of steatohepatitis, which is a very common liver disease even among people who consume little or no alcohol. Use our products responsibly and follow the advice of a licensed medical practitioner at all times. This enzyme requires for its activity the presence of tetrahydrobiopterine, oxygen, NADPH2 and a metal, iron or copper. Serotonin, released by presynaptic serotonergic neurons in synaptic clefts, activates specific receptors and is partly reuptaken by presynaptic neurons. The concentration of a compound in an organ, static view of a dynamic phenomenon, is not necessarily a good representation of metabolic activity and turn-over. Essential amino acids are the ones that are needed by the body but are not produced within the body and are to be obtained from food.

According to researchers, anxiety disorders and depression, in many cases, are caused by insufficient levels of tryptophan in body. Tryptophan supplements are also used to synthesize Niacin, which processes lipids and carbohydrates. Tryptophan supplements have shown to improve conditions and symptoms in people suffering from irritable bowel syndrome. Normally, tryptophan supplements don’t lead to side effects but still, over use is to be avoided. The activation of these 2 enzymes of the kynurenine pathway could reduce the amount of tryptophan available for serotonin biosynthesis. Moreover, other amino acids are in competition with free tryptophan and limit its entry in the brain. Serotonin and melatonin, derived from tryptophan, relax the body and regulate sleeping habits. Plasma cortisol, whose level is increased in depressed patients, decreases free L-tyrosine and free L-tryptophan concentrations in plasma, i.e. Insulin, of which secretion is increased by carbohydrates, has an opposite effect and decreases the concentration of the amino acids other than tryptophan.

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