24.07.2014
The invention relates to a device for melatonin treatment involving an adapting means which adapts the daily dose upon measurement of a body parameter of the patient or the user of the device.
Melatonin (N-acetyl-5-methoxytryptamine) is a hormone synthesized and secreted by the pineal gland.
Melatonin has been given to human beings to treat the phenomenon of "jet lag" following airplane trips associated with a change in time zones (Arendt et al.
According to a preferred embodiment of the present invention, the at least one body parameter includes body temperature, core body temperature, skin surface temperature, activity, melatonin level, Cortisol level, heart rate, breathing frequency. According to a preferred embodiment of the present invention, the delivery of melatonin occurs along a drug delivery profile. The device according to claim 1 , wherein the at least one body parameter includes body temperature, core body temperature, skin surface temperature, activity, melatonin level, Cortisol level, heart rate, breathing frequency.
The device according to any one of the claims 1 to 6 wherein the delivery of melatonin occurs along a drug delivery profile.
This is at least in part due to the circadian rhythms that trigger the anabolism and catabolism of melatonin in the human body.


According to an embodiment of the present invention, the stored data can be used to provide information that the delivery of melatonin has stopped after the device slowly decreased the daily amount of melatonin delivery. 1 shows four diagrams of activity against time of activity during the day prior to melatonin treatment, on day 1 and 2 of melatonin treatment and a desired idealized activity curve ("day x"), whereby the daily dose of melatonin was changed according to one embodiment of the present invention. As described above, this delivery profile includes an increase of 1-12% (of the total daily melatonin dosage), until about 15% of the daily dose is given in one hour; after that the hourly dose is lowered by 1-12% per hour. By doing so, it is possible for a wide range of applications within the present invention to smoothen the adjustment to the preselected ratio and limit melatonin delivery when the endogenous production takes over such as in the treatment of the delayed sleep phase syndrome. It should be noted that instead of the valves 50, also further means might be possible to deliver the melatonin. In case the melatonin dose does not need to be adjusted (path "no" in the flow chart), the melatonin dosage and timing is continued without a change. Melatonin is secreted into the blood stream and possibly also into cerebrospinal fluid (CSF) simultaneously. According to one embodiment of the present invention (not shown in the Figs), the device uses electrophoresis to provide active delivery of melatonin.


6, at first the melatonin is delivered (as expressed by the box "Deliver Melatonin dosed & timed") and the activity is measured ("measure activity").
The measurement of the activity may occur while the melatonin is being delivered as well as after the delivery (as indicated by the "reverse arrow"). Melatonin reduced the time awake before sleep onset and diminished sleep latency and number of awakenings. Most of the published studies are consistent with the assumption that melatonin has mild sedative and hypnotic properties and may be a natural, sleep-inducing and sleep-organizing signal in humans.
In addition, melatonin has been reported to lower intraocular pressure in glaucoma, to inhibit breast cancer (U.S.



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Comments Daily melatonin dosage

  1. BREAST
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  2. Seytan_Qiz
    Improve the muscle tone in your face.