The study was co-led by UC Berkeley neuroscientists Bryce Mander and William Jagust, a leading expert on Alzheimer’s disease.
The research was performed on 26 older adults, between the ages of 65 and 81, who showed no existing evidence of dementia or other neurodegenerative, sleep or psychiatric disorders. Getting less sleep can significantly affect a person's ability to memorize things or focus on tasks.
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A Mosaic Weighted Blanket® can be helpful in settling the hyperactivity and disorganization through the soothing effects it has on the body. The team has received a major National Institutes of Health grant to conduct a longitudinal study to test their hypothesis that sleep is an early warning sign or biomarker of Alzheimer’s disease.(Left) Heavy deposits of the toxic protein, beta-amyloid, shown in red in the brain on the right, are linked to poor sleep and may be paving the way for Alzheimer’s disease. First, they each received PET scans to measure levels of beta-amyloid in the brain, after which they were tasked with memorizing 120 word pairs, and then tested on how well they remembered a portion of them.The study participants then slept for eight hours, during which EEG measured their brain waves.
The ill-effects of sleep deprivation have now gone up to an all new level, involving changes in your brain. Often the disorder is recognized and diagnosed in elementary-school-age children who show signs of constant distraction, excessive talking, fidgeting, and mood swings. Studies have shown that anxiety and depression can develop and disrupt regular sleeping habits.
Gentle pressure exerted on the body signals the production of serotonin, a hormone which calms the mind and body. A brain benefiting from deep sleep brain waves and an absence of beta-amyloid is shown on the left.

When serotonin converts into another hormone called melatonin, sleepiness is triggered naturally.
At this point, researchers tracked activity in the hippocampus, where memories are temporarily stored before they move to the prefrontal cortex.“The more you remember following a good night of sleep, the less you depend on the hippocampus and the more you use the cortex,” Walker said. Moreover, a 2013 University of Rochester study found that the brain cells of mice would shrink during non-rapid-eye-movement (non-REM) sleep to make space for cerebrospinal fluids to wash out toxic metabolites such as beta-amyloid.“Sleep is helping wash away toxic proteins at night, preventing them from building up and from potentially destroying brain cells,” Walker said. It’s a vicious cycle.“But we don’t yet know which of these two factors — the bad sleep or the bad protein — initially begins this cycle.

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