Insomnia is a common sleep problem that negatively affects your ability to either fall or stay asleep.
Another category of illnesses that will cause insomnia by waking you up in the middle of the night are conditions that cause chronic pain. Acid reflux is another condition that can wake you up in the middle of the night due to pain. Even if the medical condition you have does not cause insomnia, the medication you are using to treat it might. There are many health problems that cause insomnia, often because the symptoms of those issues disrupt sleep themselves.

Anxiety and depression are top offenders, as they put you in a state of hyper-arousal, also known as fight or flight. Common medications that cause insomnia include alpha-blockers, beta-blockers, corticosteroids, SSRI antidepressants, ACE inhibitors, angiotensin II-receptor blockers, cholinesterase inhibitors, non-sedating antihistamines, glucosamine and chondroitin, and statins. Chronic pain will both make it difficult for you to fall asleep in the first place and often cause you to wake up in the night during a bad pain flare.
This means that if you eat too close to bedtime, you will often experience acid reflux while you are sleeping. If you are taking any of these medications and are experiencing insomnia, talk to your doctor about potential solutions.

He or she may switch you to a different type of medication or work with you to find solutions to treat the insomnia as a symptom.

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