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This journal is a member of and subscribes to the principles of the Committee on Publication Ethics. In this simplified cartoon Akt modulates the activity of transcription factors important for Pol I activity and rRNA synthesis, thereby regulating ribosome biogenesis and global proteins synthesis.


These mRNAs encode for proteins, which are involved in cell growth, cell proliferation and cell survival. Alterations in translational control of the downstream Akt-signaling pathway represent an important step towards cellular transformation.






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