29.06.2014

Trying to conceive with endometriosis

Ask any of the five and a half million women and girls in the USA and Canada today that suffer from Endometriosis to describe it and they will all tell you that this chronic disease is extremely agonizing and somewhat debilitating.
Although Endometriosis can be suspected based on the above symptoms, there are plenty of other diseases that share the same symptoms so a proper diagnosis needs to be made. In cases of moderate to severe endometriosis, surgical excision of all of the tissues in addition to reconstruction and restoration of the reproductive organs has been shown to achieve pregnancy rates that are higher than for untreated women.
However, there are many cases where women who are trying to conceive with endometriosis have been quite successful at becoming pregnant. However, for a person with endometriosis, tissues from the lining of the uterus travels through the fallopian tubes and begins to grow outside the uterus on other organs, such as the ovaries, pelvis, bladder, and abdomen.
For a woman that has Endometriosis, all of the out-of-place endometrial tissue growths in the viscera will respond to the menstrual cycle in the same way that the tissue of the uterine lining does – by building up each month, then breaking down and shedding itself.


The Endometriosis Institute  explains that the only way to do this is through a laparoscopy, which is a minor surgical procedure performed under anesthesia. Studies have shown that 25% to 50% of infertile women have endometriosis while 30% to 50% of women with endometriosis are infertile. A few studies suggest that post-surgical medical suppression with gonadatropin agonists, such as Lupron, Synarel, and Zoladex, can help improve pregnancy rates in women with endometriosis. Endometriosis is believed to be the leading cause of infertility, affecting women between the ages of 25 and 40.  Studies have also shown that endometriosis sufferers conceive at rates that are lower than women without endometriosis, but miscarriages are more common in endometriosis patients than in those women without.
Such treatments can be used along with excisional therapy and medical suppressive therapy, especially if there is any suspected residual disease. Those who suffer from endometriosis are also prone to progesterone deficiency that can make implantation weak, resulting in early miscarriages.


Although there have been quite a few randomized clinical trials (RCTs) conducted, a review of 13 RCTs that involved almost 800 infertile women with endometriosis found that there was no evidence that ovulation suppression was any better than taking a placebo in women who wished to conceive.
However, the combination of the two treatments has proven to be most beneficial when paired with in vitro fertilization.



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