26.08.2014

Pregnancy rates after ivf

When couples are trying on their own to get pregnant the fertility issue that reduces chances for success is related to the quality of the eggs. The charts below illustrate the rate of live births per embryo transfer procedure by the age of the recipient of the embryos.
Although these age and fertility statistics are specifically about IVF success, there is a similar loss in fertility potential with aging in the general "normal fertile" population.
The graphs below are from the 2012 ART Success Rates report published by the CDC, Centers for Disease Control and Prevention, a US government agency.
Another point shown here is that there not a substantial decline in success by age of the recipient woman with donor egg IVF. The national summary (as well as clinic specific results) of IVF success rates for cycles done in years 1995 through 2012 are posted on the CDC website.
All clinics have some upper age limit after which they will not perform in vitro fertilization with the woman's own eggs. High quality IVF results in better embryo quality which leads to better chances for successful outcomes - at any age. Most IVF centers are willing to attempt IVF using the female partner's eggs until about age 44, after which the couple would be offered egg donation as the only realistic advanced fertility treatment.
A comparison of clinic success rates may not be meaningful because patient medical characteristics, treatment approaches and entrance criteria for ART may vary from clinic to clinic. Providing high pregnancy rates with minimum risk after in vitro fertilization requires high quality embryos. The technique of CCS after conventional in vitro fertilization is to grow embryos to day 5, the blastocyst stage.


Comprehensive Chromosome Screening (CCS) is a new way of selecting high quality embryos, with high implantation and pregnancy rates. PFC offers CCS as an option for patients undergoing in vitro fertilization (IVF), as a treatment for recurrent miscarriage, prevention of aneuploidy in pregnancy, and for women that wish to improve implantation rates, reduce miscarriage rates, and reduce the risk of multiple pregnancy after IVF. They also have substantially lower success rates with fertility treatments including in vitro fertilization (IVF).
With treatments such as IVF, the issue that holds back success potential is both egg quality and egg quantity. With IVF treatment we hope to get multiple embryos so we can choose the best ones from a group for transfer back to the uterus.
The rate of chromosomal abnormalities in eggs (and therefore also in embryos) increases significantly with advancing female age.
However, when going through a fertility treatment such as IVF, the quantity of eggs remaining influences response to ovarian stimulating medications. This report was generated from national data from hundreds of clinics and well over 100,000 IVF cycles. The report summarizes national data from hundreds of clinics and many thousands of IVF treatments. CCS is a treatment for women that wish to improve implantation rates, reduce miscarriage rates, and reduce the risk of multiples after IVF. At Pacific Fertility Center 62% of women aged 40 and under that received an embryo selected with CCS conceived a clinical pregnancy (n=345 transfers in 2012 & 2013).
Half or more (sometimes all) embryos in a particular IVF treatment cycle are aneuploid, and while we can’t prove this, we suspect that the majority of natural conceptions are affected by aneuploidy as well.


Egg quality translates over to embryo quality - which is by far the most important factor determining if IVF works.
Embryos that look good under the microscope don’t always have what it takes to produce a pregnancy. Embryo implantation rates were 66% per embryo transferred for each age group in women age 40 and under.
It appears that implantation rates actually improve with a delayed transfer in a cycle after the retrieval cycle. Under age 30, roughly half of embryos will be normal, and most young women find multiple euploid embryos after testing. For updated information about our fertility clinic, infertility treatment options, IVF success rates and more, read our infertility doctor blog or subscribe to Pacific Fertility Center's Fertility Flash newsletter. Embryos that have normal chromosomal analysis after PGS have a very high potential for implantation and live birth. Selecting high quality embryos, those with the highest pregnancy potential, can reduce the numbers of embryos transferred, avoiding miscarriage, increasing pregnancy rates, and improving the health of children born after IVF. In a later natural cycle, the normal endometrial lining is restored with normal implantation rates.




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