13.03.2015

Ivf over 40 child

Almost three-quarters of people do not think women should receive IVF to help them conceive beyond their natural childbearing years, a poll has found.
The Shameless actress travelled to Cyprus for IVF treatment and conceived her daughter, Flame, with donor eggs, giving birth aged 50.Two-thirds of those surveyed said they thought children born to women aged 50 to 55 were negatively affected by having an older mother. Another example: A 41 year old nurse married to a 39 year old physician had already gone through three conventional IVF cycles elsewhere with PGD and no success.
A great example of the superiority of mini-IVF for older women is a 43 year old who had gone through 5 previous conventional high dose stimulation IVF cycles since she was 40 years old.
A very determined 45 year old woman underwent four cycles of mini-IVF stimulation for IVF resulting on a total of 14 frozen stored embryos, because she knew how low her chance was for pregnancy per embryo with her own 45 year old eggs.
A dramatic example of mini-IVF for women over 40 is a typical case of what we call secondary infertility, where the couple was able to conceive and deliver a healthy baby when they were younger, but now find themselves infertile in their attempt to have another child a few years later. Women over 38 years of age often have very few eggs, respond poorly to conventional ovarian stimulation, and because of lower pregnancy rates, are often just cancelled by IVF clinics for fear that such cases will lower their reportable statistics. Now the couple wanted a second child and had been told that donor eggs was her only option because of her age and low ovarian reserve. For them the news is even harsher when an IVF clinic tells them they will need to use donor eggs. Now at age 43, with such a low ovarian reserve, three years later, they wanted to try for another child. One 44 year old woman who was turned down by many IVF centers unless she agreed to use donor eggs, underwent two mini-IVF cycles at our center in which we were able to retrieve 4 eggs each time, resulting remarkably in 4 embryos each time, which were frozen by vitrification and stored for eventual transfer. Firstly, it is hard to overstate how crucial is the purity of air quality in the lab as well as in the operating room. But with this mini-IVF approach of storing up vitrified embryos month by month in older women, we have a remarkable pregnancy rate even in women over 42 years of age of over 50%, and this year thus far 67%.


Most IVF centers will turn these women down if they do not agree to donor eggs, or else string them along with tests and meager treatments that are doomed to fail, until they finally agree to donor eggs. The advantage of mini-IVF is that we can get better quality embryos at a much lower cost per cycle, store them up safely with vitrification, and spend less than the conventional IVF cycles would cost.
Many IVF programs just have a small local pool of egg donors, which we feel is not a favorable approach. Also, such patients usually require huge doses of expensive drugs that can add another $6,000 or $7,000 to the already high cost of conventional IVF, bringing total costs to as much as $18,000 or more per cycle. We placed her on a program of mini-IVF back to back cycles to store up embryos by vitrification over the next year. He had had a vasectomy 20 years earlier as a young man, and had not decided till this late age finally, after 12 years of happy marriage, that they both really wanted a child. These cases of women over 46 getting pregnant with their own eggs are unusual, but it is nonetheless quite possible if donor eggs are not an option for them. The misery this brave and beautiful young woman had to go through, being told by everyone that she could never have her own children, and her determination not to be swayed by the naysayers was truly inspirational. We have been offering donor egg IVF for over 24 years, and therefore have had a chance to follow these children and their parents for a almost a quarter century. Mothers in their early twenties are becoming increasingly rare, while those over 45 (just four years away from the average age of menopause) more than trebled between 2000 and 2011 – to 1,832, from a total of 723,913 live births.
She still has 6 more frozen embryos remaining, and so it is possible she could even have a second child in a few years, before she is 50, to be a sibling for this miracle baby she had from mini-IVF with her own eggs at age 46.
Their local IVF center laughed at them; but because they were physicians, they knew not to give up hope. She went through a total of 6 cycles of IVF just to store up embryos, retrieving only a few eggs at a time, and eventually storing up 10 embryos.


Both the children and the parents are well adjusted and completely happy with their lives as a result of the donor egg IVF. Both were physicians, only 34 years old, and had been told by several IVF centers they had visited that she had only a few follicles left, was about to go into early premature menopause, and was not a candidate for IVF with her own eggs. So this time, again with mini-IVF, we actually got 6 eggs and 5 good quality embryos, giving them two more children, even at age 43, when every other center would automatically turn them down because the results are normally so poor with conventional IVF in women over 40. We finally figured out these doctors were trying to waste enough time to force us into using donor eggs, rather than pursue a plan that would help us try to have our OWN children.
The reason it is so often misunderstood is that what appears to be ingrained character in a child is in truth, a subtle result of early interaction with parents in the first two or three years of life.
The character, personality, intelligence, and even coordination motor skills of the child are dependent on that emotional bonding and complex interaction with parents in the first few months and years. Even the treatments that are supposed to offer hope to the childless may prove to be a mixed blessing. Recent research suggests that the drug Clomid, which is often used to stimulate women’s ovaries, may be partly responsible for the higher rate of birth defects among children conceived through fertility treatments.
Infant mortality rates are so low (0.46 per cent of babies under a year old) that the death of a child seems an unimaginable disaster, rather than the commonplace tragedy it once was. The anxiety I feel on my own behalf, as his daughter, is exacerbated by panic at the thought that my children might grow up without really knowing him. A woman who has a baby at 35 is more likely than not to have died by the time that child is 46.



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