Is benadryl safe during pregnancy

Many doctors recommend the usage of 25mg to 50mg oral dose every six hours in the beginning of your pregnancy (First Trimester). Join our newsletter to receive pregnancy articles and information on what to expect during the next nine months.
Yes, Benadryl also known, as Diphenhydramine and Tylenol PM are safe during pregnancy to help you sleep. Take 1 to 2 Benadryl tablets (25mg to 50mg), every 6 hours as needed.'>Is Benadryl Safe During Pregnancy. Adequate, well-controlled studies in pregnant women have not shown increased risk of fetal abnormalities despite adverse findings in animals, or, in the absence of adequate human studies, animal studies show no fetal risk. Upon doing some research on Benadryl during pregnancy, I discovered that, although most studies indicate that the drug is fairly safe to use during pregnancy, limited evidence that suggests that Benadryl increases the risk of cleft palate. Upon further investigation of the association between the use of antihistamines during pregnancy and blindness, I discovered a few potential problems with the study that found the link. The few other human studies that I found on the use of Benadryl during pregnancy also indicate a serious need for further research.

To treat my nasal allergy symptoms, I have been taking 25 milligrams of diphenhydramine almost every night for the past three months of my pregnancy with the approval of my midwife.
However, with the potential association between the use of antihistamines during the last two week of pregnancy and an increased risk of blindness, I also plan to stop or limit my nightly use of Benadryl as I enter the second half of the third trimester. More specifically, animal studies conducted on pregnant rabbits indicate that large doses of Benadryl do not increase the risk of problems in offspring.
However, because Flonase is a category C drug, I have opted to refrain from using the medication before and during pregnancy. However, the number of adequate, well-controlled human studies on the drug during pregnancy are lacking.
Additional studies still need to be conducted on the potential association between Benadryl during pregnancy and an increased risk of cleft palate.
Flonase is a steroidal drug, but the study found that side effects are reduced when steroids are administered as aerosols in the nose or lung and therefore seem well suited for use in pregnancy. Despite trying other treatment options, only Benadryl (diphenhydramine) offers me any relief from my allergies.

I additionally read that the use of antihistamine drugs during the last two weeks of pregnancy may increase the risk of a certain eye problem that cause blindness (retrolental fibroplasia). However, even if this fall does not bring me the same relief, I still plan on reducing or eliminating my use of Benadryl during the last part of my pregnancy — just in case.
Despite that the study found that the incidence of retrolental fibroplasia in premature infants exposed to antihistamines during the last two weeks of pregnancy was 21% compared to 11% in premature infants not exposed, the fairly significant problems with the study means that the results are not widely applicable. Thus, I have opted to take a low dose of Benadryl once a day to alleviate my allergy symptoms enough to sleep.
And I would rather risk some extra fatigue during late pregnancy than potential blindness for my second child — at least until additional studies confirm or disprove the earlier association.

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