Folic acid pregnancy miscarriage

The study authors note that approximately one third of pregnancies are lost after the embryo implants in the uterus, often before a pregnancy is diagnosed; thus, pregnancy loss the most frequent adverse pregnancy outcome. The authors explain that folic acid supplementation may have reproductive benefits beyond the prevention of neural tube defects. The study group comprised women in the Nurses' Health Study II who self-reported a pregnancy between 1992 and 2009. The authors concluded that higher intake of folate from supplements was associated with reduced risk of miscarriage.
Folic acid occurs naturally in many foods; among plants, are especially plentiful in dark green leafy vegetables.
Folic Acid is a key B Vitamin required by your body for the repair and production of new cells; particularly during pregnancy.
Regular folic acid undergoes a 4-step enzymatic conversion process to achieve L-methylfolate - the active form of folic acid used by your body.
Unfortunately, over 50% of people have a MTHFR genotype variation and are unable to fully convert regular folic acid to L-methylfolate. Introducing FolaPure™ (L-methylfolate) - the active form of folic acid which can be immediately absorbed by your body. L-methylfolate is also proven to lower levels of homocysteine - an amino acid linked to cardiovascular disease and more importantly, pregnancy complications.
Leyva, M., Folic acid intake and its effects on the prevention of neural tube defects, the masking of vitamin B12 deficiency and the reduction of homocysteine. It is especially important to have adequate folic acid before and during pregnancy because it reduces the risk of neural tube defects (abnormalities of the brain and spinal cord). Chromosomal abnormalities are involved in approximately 50% of all miscarriages, the remaining 50% may be preventable and are related to environmental factors.

Supplementation with the vitamin in animals promotes embryo and fetal survival rates throughout pregnancy; however, the association between its intake and fetal survival in humans is less clear. Dietary folic acid and supplement use was assessed every four years, beginning in 1991, via a food frequency questionnaire. Compared with women in the lowest quintile (20%) of pre-pregnancy folic acid intake (less than 285 micrograms per day), those in the highest quintile (greater than 851 micrograms per day) had a relative risk of spontaneous abortion of 0.91. They recommended that women who might become pregnant should use supplemental folic acid for neural tube defect prevention and because it may decrease the risk of miscarriage. These foods are healthy and should be consumed; however, women who are pregnant or could possibly become pregnant should take a supplement. Folic Acid is proven to reduce the risk of neural tube defects (NTDs) and birth defects such as spina bifida and anencephaly by as much as 70% if taken at least 1 month before pregnancy. Dihydrofolate Reductase (DHFR) converts folic acid to dihydrofolate (DHF), DHF is then converted to tetrahydrofolate (THF), THF is converted to 5,10-methylene THF, and the last conversion step involves Methylenetetrahydrofolate Reductase (MTHFR) converting 5,10-methylene THF to L-methylfolate. This limited absorption results in a significant reduction in the amount of L-methylfolate made available to your body; limiting your ability to build and maintain healthy reserves of folic acid and significantly increasing your risk of birth defects. FolaPure™ (L-methylfolate) is not affected by MTHFR genotype variations and does not undergo enzymatic conversion.
Such pregnancy complications include: preeclampsia, low birth weight, miscarriage, recurrent pregnancy loss, placental abruption and premature fetal development. A new study has found that women who do not have adequate folic acid intake or at increased risk for stillbirth and miscarriage. They explain that the role of dietary factors in human reproduction is limited; however, it is extremely likely that intake of certain nutrients, particularly folate, could positively influence the odds of a successful pregnancy outcome. Therefore, they conducted a study to assess the relationship between pre-pregnancy folic acid intake and risks of miscarriage and stillbirth in a large group of women who had a wide range of folic acid intake.

Pregnancies were self-reported with pregnancies lost spontaneously (spontaneous loss at less than 20 weeks of gestation and stillbirth at 20 or more weeks of gestation); these pregnancies were compared to pregnancies terminating in ectopic pregnancy, induced abortion, or live birth. This active form of folic acid is proven to be up to 700% more bioavailable than regular folic acid. Stanley, Dietary folate as a risk factor for neural-tube defects: evidence from a case-control study in Western Australia. Folic acid prevents neural tube defects; thus, the American College of Obstetricians and Gynecologists recommends that all women planning or capable of pregnancy take 400 micrograms of folic acid daily. The goal was to expand on previous studies by examining dose–response relationships comparing food with supplemental folate.
Compared with women without supplemental folate intake (0 micrograms per day), those in the highest category (greater than 730 micrograms per day) had a relative risk of spontaneous abortion of 0.80.
Following his specialty training, he practiced obstetrics and gynecology in Orange County, California for 25 years. They theorized that higher folic acid intake of folate, particularly supplemental folate, is associated with reduced risk of pregnancy loss. The association of pre-pregnancy supplemental folate with risk of spontaneous abortion was consistent across gestational period of loss. They explain that folic acid supplements are more readily absorbed and available to the body than folic acid from food.

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