03.06.2015

Fertility after age 40

At age 40 and above women have reduced fertility potential as compared to that seen in younger women.
When couples are trying on their own to get pregnant the fertility issue that reduces chances for success is related to the quality of the eggs.
The charts below illustrate the rate of live births per embryo transfer procedure by the age of the recipient of the embryos.
Although these age and fertility statistics are specifically about IVF success, there is a similar loss in fertility potential with aging in the general "normal fertile" population.
The graphs below are from the 2012 ART Success Rates report published by the CDC, Centers for Disease Control and Prevention, a US government agency.
Another point shown here is that there not a substantial decline in success by age of the recipient woman with donor egg IVF. All clinics have some upper age limit after which they will not perform in vitro fertilization with the woman's own eggs. You may find it encouraging knowing that the number of women over the age of 30 having babies has risen in recent decades (ONS 2010) .
The average age at which women have in vitro fertilisation (IVF) treatment in the UK is rising.
While many men remain fertile into their 50s and beyond, the proportion of men with sperm disorders increases with age (RCOG 2011). Figures for women aged 30 to 34 and aged 35 to 39 are fairly similar, with 94 per cent and 90 per cent conceiving within two years, respectively (NCCWCH 2013: 65). As a woman ages it is more likely that she may have had longer exposure to a condition that has not been treated. Age aside, there are some steps you can take to give yourself the best possible chance of conceiving and having a healthy pregnancy. However, research shows that many women don’t realize how quickly their fertility can drop, and how early that can start to happen. This gradual change in fertility is mostly due to a decrease in the numberand quality of eggs in your ovaries.The loss of eggs begins even before you are born. There are several medical technologies that can help some women get pregnant, although they cannot necessarily make up for age-related fertility decline. In vitro fertilization (IVF): Eggs are removed from your ovaries and are fertilized with sperm in a laboratory. For a woman without many eggs left, this may be the only effective treatment; pregnancy rates associated with oocyte donation are significantly higher than those associated with ovarian hyperstimulation or in vitro fertilization alone.


The good news is that many women over the age of 35 become pregnant and have healthy pregnancies and babies. It is standard to offer all pregnant women, regardless of age, noninvasive screening for chromosomal anomalies using ultrasound and blood tests. If you have been trying to conceive and have not been successful, your doctor, nurse or midwife may refer you to a fertility specialist.
One of the first things your health-care provider will check is your partner’s fertility, by doing a sperm analysis. The effect of a father’s age on fertility and pregnancy are not as well defined as for maternal age.
They also have substantially lower success rates with fertility treatments including in vitro fertilization (IVF).
The rate of chromosomal abnormalities in eggs (and therefore also in embryos) increases significantly with advancing female age.
However, when going through a fertility treatment such as IVF, the quantity of eggs remaining influences response to ovarian stimulating medications. You know the most fertile years are in your 20s, but want to get a better idea of how age affects your fertility.
Fertility starts to decline for women from about the age of 30, dropping down more steeply from the age of 35 (CKS 2007, NCCWCH 2013:65). After 35 years, the proportion of women who experience infertility, miscarriage or a problem with their baby increases.
Even though male fertility also declines with age (RCOG 2011, Utting and Bewley 2011), it tends to happen gradually for men. Many of us also don’t know that fertility treatments cannot always make up for that decline. It is important for women and their partners to understand how age can affect fertility, pregnancy and childbirth, and to what extent medical technologies can help. This varies from woman to woman; unfortunately, there is no way to reliably predict fertility decline. As you get older, you are more likely to have experienced other medical problems – such as endometriosis, fibroids, tubal disease or polyps – which can reduce your fertility. A fertilized egg is then transferred to your uterus, with the hope that it will implant itself. Once her egg has been fertilized in a laboratory, it is transferred to your uterus, with the hope that it will implant itself.


Women who become pregnant over the age of 35 have an increased risk of miscarriage, ectopic pregnancy, preeclampsia, hypertension, gestational diabetes, placental complications, intrauterine growth restriction, and caesarean section. For women who are under the age of 35, this is usually done after one year of trying to become pregnant.
There are many causes of infertility – for both males and females – and not all are related to age. There is some research that suggests a decrease in fertility for men over 40, and an increase in genetic disorders for children of older fathers.
By the age of 40 only two in five of those who wish to have a baby will be able to do so (RCOG 2011).
The decline in male fertility can affect the health of the children they may go on to have (Utting and Bewley 2011). More than one egg fertilised and more than one baby (Beemsterboer et al 2006, Utting and Bewley 2011)!
This could prevent fertilisation altogether or increase the likelihood of an ectopic pregnancy (CKS 2007, NCCWCH 2013:129, Utting and Bewley 2011).
The paradox of declining fertility but increasing twinning rates with advancing maternal age.
Does this mean age has something to do with my situation or You suggest I start seeking professional help. The condition of your eggs also changes as you age; they have a higher rate of chromosomal anomalies, which increases your chances of early miscarriage. Older women, particularly those over 40, should consider IVF after only one or two unsuccessful cycles of ovarian hyperstimulation. Women aged 35 to 37 should be referred to a specialist after 6 months of trying to become pregnant, and women who are 38 or older and are trying to conceive should be referred to a specialist without waiting.
Embryos that have normal chromosomal analysis after PGS have a very high potential for implantation and live birth.



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