18.11.2015

Chances of having a down syndrome baby over 40

For centuries, people with Down syndrome have been alluded to in art, literature and science.
In recent history, advances in medicine and science have enabled researchers to investigate the characteristics of people with Down syndrome. Mosaicism (or mosaic Down syndrome) is diagnosed when there is a mixture of two types of cells, some containing the usual 46 chromosomes and some containing 47.
In translocation, which accounts for about 4% of cases of Down syndrome, the total number of chromosomes in the cells remains 46; however, an additional full or partial copy of chromosome 21 attaches to another chromosome, usually chromosome 14. The additional partial or full copy of the 21st chromosome which causes Down syndrome can originate from either the father or the mother. Down syndrome occurs in people of all races and economic levels, though older women have an increased chance of having a child with Down syndrome.
Since many couples are postponing parenting until later in life, the incidence of Down syndrome conceptions is expected to increase.
Once a woman has given birth to a baby with trisomy 21 (nondisjunction) or translocation, it is estimated that her chances of having another baby with trisomy 21 is 1 in 100 up until age 40. There are two categories of tests for Down syndrome that can be performed before a baby is born: screening tests and diagnostic tests.
The diagnostic procedures available for prenatal diagnosis of Down syndrome are chorionic villus sampling (CVS) and amniocentesis. Individuals with Down syndrome are becoming increasingly integrated into society and community organizations, such as school, health care systems, work forces, and social and recreational activities. Due to advances in medical technology, individuals with Down syndrome are living longer than ever before.
In recent years, Down syndrome has become more common, and children with Down syndrome are living longer. In 2007, the medical guidelines changed from only offering women 35 years old and older prenatal testing for Down syndrome to offering it to all expectant mothers.


Another reason for offering prenatal testing to all expectant mothers was the assertion that most children with Down syndrome are born to women under the age of 35. The age of the mother is the only factor that has been shown to increase the risk of having a baby with Down syndrome. The presence of the extra full or partial chromosome 21 causes the characteristics of Down syndrome.
Maternal age is the only factor that has been linked to an increased chance of having a baby with Down syndrome resulting from nondisjunction or mosaicism. A 35 year old woman has about a one in 350 chance of conceiving a child with Down syndrome, and this chance increases gradually to 1 in 100 by age 40.
Individuals with Down syndrome possess varying degrees of cognitive delays, from very mild to severe. The site provides answers to common questions, educates about Down Syndrome and shares the stories of other parents with similar situations.
Resta’s article indicate that he is correct in stating that the increasing number of pregnancies occurring in women who are 35 years of age and older has recently resulted in that cohort accounting for slightly more than half the number of Down syndrome fetuses conceived in the United States.
This, then, means that there is an even higher percentage of older mothers being pregnant and, ergo, even more cases of Down syndrome are due to pregnancies of women over the age of 35.
Instead of the usual 46 chromosomes present in each cell, Lejeune observed 47 in the cells of individuals with Down syndrome. Still, many physicians are not fully informed about advising their patients about the incidences of Down syndrome, advancements in diagnosis, and the protocols for care and treatment of babies born with Down syndrome.
These tests do not tell you for sure whether your fetus has Down syndrome; they only provide a probability. However, because younger women are more likely to have babies than older women, 80% of babies with Down syndrome are born to women younger than 35 years of age. The net result is that since about the year 2000, women aged 35 and older have accounted for slightly more than 50% of pregnancies with Down syndrome.


Contrary to the CDC statement, women under the age of 35 account for a minority of Down syndrome pregnancies, and have since the start of this century. Although other people had previously recognized the characteristics of the syndrome, it was Down who described the condition as a distinct and separate entity.
It was later determined that an extra partial or whole copy of chromosome 21 results in the characteristics associated with Down syndrome. Together with a woman's age, these are used to estimate her chance of having a child with Down syndrome. So, the earlier and just-as-accurate prenatal test justified offering prenatal testing for Down syndrome to all expectant mothers. These blood tests are often performed in conjunction with a detailed sonogram to check for "markers" (characteristics that some researchers feel may have a significant association with Down syndrome). This means that in 2002 about 83,000 children and teenagers were living with Down syndrome.[Read summary ]Researchers estimated that in 2008 about 1 out of every 1,200 people (children, teens, and adults) living in the United States had Down syndrome.
In 2007, on average, persons with Down syndrome lived to be about 47 years old.[Read summary ]Many factors can affect how long a person with Down syndrome lives. Sometimes infants with Down syndrome are born weighing less than 1,500 grams, or about 3.3 pounds.
In the same time period, about 88% of babies born with Down syndrome survived to 20 years of age.[Read summary ]The number of infants with Down syndrome that die before one year of age has declined over time. Responses from the NSCSHN questionnaire indicated the following: Nearly 60% of families of children with Down syndrome provided health care at home.



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