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There are numerous causes of Leaky Gut Syndrome all associated with a break down in the normally healthy probiotic inner ecology or mircobiome. DRUGS: leaky gut will increase and be affected by OTC (over the counter) aspirin and related NSAID (nonsteroid anti-inflammatory drugs as well as Rx prescription drugs.
Evidence that chronicalcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats.


Whereas any of the factors below can individually or collectively cause temporary harm from which the micobiome can adapt and bounce back, repeated use or exposure over time will cause actual damage to the bowel epithelial cells and the tight juncture between them.
This tight juncture breakdown creates a severe compromise to the integrity of the GI tract, allows passage of unwelcome toxins directly into the blood stream, thereby contributing to a variety of well documented disease related effects such as IBS (irritable bowel syndrome), Intestinal permeability (leaky gut), Crohn's disease (CD), ulcerative colitis (UC), collectively called inflammatory bowel disease (IBD).
Advanced breakdown contributes to immune-mediated conditions characterized by a chronic inflammation of the gut such as Rheumatoid Arthritis (RA) and Systemic Lupus.





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