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One of the challenges in human nutrition is maintaining a balance between food intake, storage, and energy expenditure.
Both physical and chemical digestion begin in the mouth or oral cavity, which is the point of entry of food into the digestive system. The chemical process of digestion begins during chewing as food mixes with saliva, produced by the salivary glands ([link]).
The stomach lining is unaffected by pepsin and the acidity because pepsin is released in an inactive form and the stomach has a thick mucus lining that protects the underlying tissue.
The large intestine reabsorbs the water from indigestible food material and processes the waste material ([link]). The organs discussed above are the organs of the digestive tract through which food passes. The liver is the largest internal organ in humans and it plays an important role in digestion of fats and detoxifying blood. The pancreas secretes bicarbonate that neutralizes the acidic chyme and a variety of enzymes for the digestion of protein and carbohydrates. The human diet should be well balanced to provide nutrients required for bodily function and the minerals and vitamins required for maintaining structure and regulation necessary for good health and reproductive capability ([link]). Explore this interactive United States Department of Agriculture website to learn more about each food group and the recommended daily amounts.
The organic molecules required for building cellular material and tissues must come from food. Proteins in food are broken down during digestion and the resulting amino acids are absorbed.
While the animal body can synthesize many of the molecules required for function from precursors, there are some nutrients that must be obtained from food.
The fatty acids omega-3 alpha-linolenic acid and omega-6 linoleic acid are essential fatty acids needed to make some membrane phospholipids. Obesity With obesity at high rates in the United States, there is a public health focus on reducing obesity and associated health risks, which include diabetes, colon and breast cancer, and cardiovascular disease.
Fatty foods are calorie-dense, meaning that they have more calories per unit mass than carbohydrates or proteins. Some amino acids can be synthesized by the body, while others need to be obtained from diet. Accessory organs play an important role in producing and delivering digestive juices to the intestine during digestion and absorption.
Minerals—such as potassium, sodium, and calcium—are required for the functioning of many cellular processes. Insulin - An islet cell-produced, anabolic hormone that controls glucose uptake, fat synthesis, and synthesis of proteins. Islet of Langerhans - Clusters of cells in the pancreas that produce the endocrine secretions of the gland.
Pancreatic duct - A conduit that passes through the pancreas, collects the pancreatic exocrine secretions of enzymes, water, and electrolytes, and carries them to the ampulla of Vater. Acute pancreatitis occurs in 1 in 500 acute admissions and severe attacks have a 20-50% mortality rate. A small amount of pancreatic amylase normally escapes into the circulating blood and, having a molecular weight of only about 45,000, is readily excreted by the kidney into the urine. A few hours after the onset of acute pancreatitis, serum amylase levels become elevated, but return to normal levels within two to three days. Amylase also is found in other tissues, especially in the salivary glands and Fallopian tubes (may cause elevated serum amylase in ectopic pregnancy), but amylase activity to a lesser extent is also present in many other tissues (liver, muscle, adipose tissue, kidney, brain, lung, intestine, spleen, serous ovarian tumors, some lung tumors and most body fluids and excretions). In contrast to some other serum enzymes, serum amylase is relatively stable; even at room temperature it is stable for several days. This is a benign condition in which normal amylase forms macromolecular complexes with immunoglobulins (IgG, IgM) or it exists as a large polymeric aggregate, resulting in a variety of “macroamylases,” which, because of their large molecular size, are not excreted by the kidney. Serum lipase activity is due to a number of enzymes from various sources, predominantly the pancreas. Serum lipase levels due to pancreatic disorders closely parallel the changes of serum amylase except that serum lipase may remain elevated longer than amylase (up to 2 weeks).
Renal excretion of amylase depends on the serum levels, and in hyperamylasemia increased amounts of amylase appear in the urine. Patients who present with the clinical picture of pancreatitis while their serum amylase is normal.
Note: This test is not frequently used since ultrasound and CT scan frequently can provide a rapid diagnosis of cholecystitis vs. Notice that the factors of urinary volume and time cancel out of the equation which eliminates the need for cumbersome, timed urinary and blood collections.
Increased clearance is not a specific response to pancreatitis, but instead may be due to competition for reabsorption of low-molecular-weight proteins by the renal tubules. Acute pancreatitis often is accompanied by accumulation of effusion fluids in the peritoneal and even pleural spaces. The hypocalcemia of pancreatitis is a complex phenomenon involving saponification as well as glucagon and gastrin release from the pancreas which in turn, stimulates calcitonin release from the thyroid, leading to phosphaturia and calciuria.
Triglycerides may be markedly elevated in acute pancreatitis often causing turbidity of the serum. Acute pancreatitis often leads to glucose intolerance, with transient hyperglycemia and abnormal glucose tolerance curves (“burnt out” pancreas).
Hyperbilirubinemia is observed, even in those patients that have no evidence of biliary obstruction. In chronic pancreatitis the biochemical changes are quite variable depending on the severity and stage of the disease.
A 38 year old man presents with an eight-hour history of acute abdominal pain that followed an alcoholic binge. Since the patient’s pain appears to be intra-abdominal that is not colicky, which diseases can be excluded? I am from Canada, I was diagnosed of chronic pancreatitis in 2007 and I have tried all possible means to get cure but all to no avail, until i saw a post in a health forum about a herbal doctor from South Africa who prepare herbal medicine to cure all kind of diseases including pancreatitis, at first i doubted if it was real but decided to give it a try, when i contact this herbal doctor via his email, he prepared an herbal medicine and sent it to me via courier service, when i received this herbal medicine, he gave me step by instructions on how to apply it, when i applied it as instructed, i was cured of this deadly disease within 6 days, I am now free from the deadly disease, my digestive system is now working perfectly, i no longer feel all the horrible pains. I was diagnosed of hepatitis in 2012 and I have tried all possible means to get cure but all to no avail, until i saw a post in a health forum about a herbal doctor from South Africa who prepare herbal medicine to cure all kind of diseases including hepatitis b virus, at first i doubted if it was real but decided to give it a try, when i contact this herbal doctor via his email, he prepared a herbal medicine and sent it to me via courier service, when i received this herbal medicine, he gave me step by instructions on how to apply it, when i applied it as instructed, i was cured of this deadly virus within 18-20 days of usage, I am now free from the virus, i was tasted negative. Greetings to the general public,I am from Philadelphia,i want to inform the public how i was cured of HERPES Simplex Virus by a Doctor called Lusanda .i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I am from United State Of America, I was diagnosed of chronic pancreatitis in 2005 and I have tried all possible means to get cured but all to no avail, until i saw a post in a health forum about a herbal doctor from Africa who prepare herbal medicine to cure all kind of diseases including pancreatitis, at first i doubted if it was real but decided to give it a try, when i contacted this herbal doctor via his email, he prepared the herbal medicine and sent it to me via courier service, when i received this herbal medicine, he gave me step by instructions on how to apply it, when i applied it as instructed, i was totally cured of this deadly disease within 16 days, I am now free from the deadly disease, my digestive system is now working perfectly, i no longer feel all the horrible pains. I started my blog last year in October writing about the liver and its critical role in detoxification, digestion, and immunity.
It is important to understand that health begins with the digestive tract working at its best. The main function of the gallbladder is to store and concentrate the bile that is made in the liver, and release it to the small intestine during digestion of fats. Bile is stored in the gallbladder where water is removed from it, and becomes more concentrated. Bile acids are needed to break up fats during digestion, to carry digested fats and fat soluble vitamins into the body, and flush out excess cholesterol and other waste products.Bile acids are made from excess cholesterol in the liver.
The liver metabolizes and gets rid of excess cholesterol by breaking it down to bile acids.Bile acids are both fat and water soluble. Concentrated bile is released from the gallbladder to the small intestine when food containing fat enters the small intestine’s duodenum for digestion. At this point, bile acids break up fat and make it easier for lipases (digestive enzymes) to digest the water-insoluble fat.Bile salts are made from bile acids. Increasing fiber intake helps to prevent gallbladder stones by helping the body to remove excess cholesterol that would otherwise end up in the bile.The reason why women are more likely to develop gallstones is because estrogen and progestins increase the levels of cholesterol in bile. Milk thistle, artichoke, turmeric, dandelion root, ginger, celandine, radish root, and peppermint are herbs that keep bile from getting saturated.
In the pharmacy, I have heard stories from women about their experiences after gallbladder removal surgery resulting from chronic stone formations or gallbladder infections.Without a gallbladder, bile acids flow out from the liver to the small intestine continuously, and are not regulated by the same mechanism or concentrated as with a gallbladder.
The information provided here is not intended to diagnose, treat, cure, or prevent any disease.


While plants can obtain nutrients from their roots and the energy molecules required for cellular function through the process of photosynthesis, animals obtain their nutrients by the consumption of other organisms. Taking in more food energy than is used in activity leads to storage of the excess in the form of fat deposits.
The teeth play an important role in masticating (chewing) or physically breaking food into smaller particles. The gastro-esophageal sphincter (or cardiac sphincter) is located at the stomach end of the esophagus.
The highly acidic environment kills many microorganisms in the food and, combined with the action of the enzyme pepsin, results in the catabolism of protein in the food. The small intestine is the organ where the digestion of protein, fats, and carbohydrates is completed. The human large intestine is much smaller in length compared to the small intestine but larger in diameter. The liver produces bile, a digestive juice that is required for the breakdown of fats in the duodenum. During digestion, digestible carbohydrates are ultimately broken down into glucose and used to provide energy within the cells of the body. All of the proteins in the body must be formed from these amino-acid constituents; no proteins are obtained directly from food. Fatty foods are also significant sources of energy, and fatty acids are required for the construction of lipid membranes.
These nutrients are termed essential nutrients, meaning they must be eaten, because the body cannot produce them. Vitamins are another class of essential organic molecules that are required in small quantities. One gram of carbohydrates has four calories, one gram of protein has four calories, and one gram of fat has nine calories.
To combat childhood obesity and ensure that children get a healthy start in life, in 2010 First Lady Michelle Obama launched the Let’s Move! The mouth is the point of ingestion and the location where both mechanical and chemical breakdown of food begins. Some essential nutrients are required for cellular function but cannot be produced by the animal body. While minerals are required in trace amounts, not having minerals in the diet can be potentially harmful. Some of the contributors to this situation include sedentary lifestyles and consuming more processed foods and less fruits and vegetables. Most cases occur in older patients (greater than 50 years old) and are frequently associated alcoholism, hyperlipidemia and biliary disease.
Thus, increased entry into the blood or decreased renal excretion generally lead to increased blood levels.
Elevations >5? the upper reference limit (URL) are considered pathognomonic for pancreatitis. However, under normal conditions 50% of the circulating blood amylase is derived from the pancreas.
They can easily be measured immunochemically; use of the P-isoenzyme increases specificity for acute pancreatitis. Since this excretion is relatively rapid following moderate bouts of pancreatitis, serum levels may be borderline or normal while urinary amylase may be elevated. The test thus can be carried out simply on simultaneously collected random samples of blood and urine. Increases in amylase clearance and the ratio of amylase to creatinine clearance are observed in a number of non-pancreatic disorders, such as burns, myeloma, duodenal perforations, and following extraperitoneal surgical procedures.
If the differential diagnosis is in doubt, particularly with normal or near normal serum and urinary amylase and lipase values, a high amylase value found in an effusion fluid supports a diagnosis of pancreatitis. Since 50% of calcium is protein bound, hypoalbuminemia will further depress calcium levels. It is of interest to mention here that in the acute “pancreatitis of hyperparathyroidism” the hypocalcemia does not occur, indicating the importance of the roles of hormones in controlling the calcium blood levels in pancreatitis. The mechanism for this elevation is not certain but may be due to hemorrhage from the pancreas. It is thought that the extravasated blood in the pancreatic area is subjected to the digestive action of the pancreatic enzymes, liberating hemin which combines with albumin to form methemalbumin. She had been diagnosed with primary hypertension and was treated with felodipine without adverse effects. Laboratory data showed increased serum concentrations of lipase and amylase; all other hematologic and biochemical variables were normal (Table 1). Amylase returned to normal after 3 days and lipase after 7 days of admission to the hospital. I have a full sensation in my stomach even although I havent eaten in 3 days and have been constantly belching.I had a blood test done about a week ago and my amylase level is 154 amd isoenzymes are 75.
This topic started a series of posts on how good health, nutrient absorption, immunity, detoxification, and reduction of inflammation starts with the digestive tract.
Bile is a yellowish-dark green fluid mix of water, electrolytes, bile acids, cholesterol, salts, lipids (fats), and bilirubin which is a protein from expired red blood cells.The liver makes about one half to one liter of bile daily.
They increase the pH of the small intestine to allow the digestive enzymes present there to activate and work at full capacity.Once the fats are digested, bile acids carry the digested fats (fatty acids and glycerol), and  fat soluble vitamins (A, D, E and K) into the body from the small intestine.
What is important is how cholesterol is used and metabolized, and how much good cholesterol (HDL) vs triglyceride blood levels we have. Birth control pills and synthetic hormonal replacement therapy increase the levels of estrogen and progestins (which are not natural progesterone). Many of the women struggle afterwards with weight gain, abdominal bloating, abdominal pain, or diarrhea right after eating. Suggestions and ideas presented in this document are for information only and should not be interpreted as medical advice, or for diagnosing  illness. At the cellular level, the biological molecules necessary for animal function are amino acids, lipid molecules, nucleotides, and simple sugars. The rise in obesity and the resulting diseases like type 2 diabetes makes understanding the role of diet and nutrition in maintaining good health all the more important.
All mammals have teeth and can chew their food to begin the process of physically breaking it down into smaller particles.
The smooth muscles of the esophagus undergo peristalsis that pushes the food toward the stomach. In response to swallowing and the pressure exerted by the bolus of food, this sphincter opens, and the bolus enters the stomach. Chemical digestion is facilitated by the churning action of the stomach caused by contraction and relaxation of smooth muscles.
The small intestine is a long tube-like organ with a highly folded surface containing finger-like projections called the villi. The chyme is mixed with pancreatic juices, an alkaline solution rich in bicarbonate that neutralizes the acidity of chyme from the stomach. The anus is an opening at the far-end of the digestive tract and is the exit point for the waste material.
Accessory organs include the salivary glands, the liver, the pancreas, and the gall bladder. The liver also processes the absorbed vitamins and fatty acids and synthesizes many plasma proteins. Complex carbohydrates, including polysaccharides, can be broken down into glucose through biochemical modification; however, humans do not produce the enzyme necessary to digest cellulose (fiber). Fats are also required in the diet to aid the absorption of fat-soluble vitamins and the production of fat-soluble hormones.
These fatty acids are stored in adipose tissue cells—the fat cells in the mammalian body whose primary role is to store fat for later use.
This condition has been observed following treatment with hog pancreatic extracts and occasionally in malabsorption syndromes, but otherwise is usually innocuous.


When the serum amylase is elevated and the lipase is normal, non-pancreatic causes of the hyperamylasemia are more likely.
It has been shown that this increase in excretion in pancreatitis is further augmented by an increased renal clearance rate of amylase (see urinary amylase). Comparisons of serum and urine tests have shown that serum enzyme tests had greater diagnostic utility than urine tests. However, methemalbuminemia is seen in many other conditions, including some with hyperamylasemia, such as ruptured ectopic pregnancy, peritoneal hemorrhage, mesenteric thrombosis, etc.
With long-standing pancreatitis, sufficient pancreatic destruction may have occurred so that amylase cannot be elaborated.
I was referred to endocrinologist for low blood sugars and I have to eat every 2 hours to maintain a decent blood sugar level, but It hurts my stomach when I eat. It appears that low levels of good cholesterol (HDL) and high triglycerides blood levels is the combination that can lead to gallstone formation.  HDL cholesterol helps by cleaning up plaque deposits in the arteties as it travels in the blood, and brings it back to the liver to be broken down. Additionally, estrogen dominance which means natural progesterone is low in comparison to estrogen, causes decreased  gallbladder bile flow.In summary, bile acid composition and quality is important to digest and transport fats and fat soluble vitamins effectively.
Hepatogastroenterology, 2000, Jul-Aug47(34),pgs 919-21Duke,James.The Green Pharmacy Herbal Handbook. The food is then swallowed and enters the esophagus—a long tube that connects the mouth to the stomach. It also contains an enzyme called salivary amylase that begins the process of converting starches in the food into a disaccharide called maltose. The peristaltic wave is unidirectional—it moves food from the mouth the stomach, and reverse movement is not possible, except in the case of the vomit reflex. When there is no swallowing action, this sphincter is shut and prevents the contents of the stomach from traveling up the esophagus. Pancreatic juices contain several digestive enzymes that break down starches, disaccharides, proteins, and fats. Two sphincters regulate the exit of feces, the inner sphincter is involuntary and the outer sphincter is voluntary. The secretions of the liver, pancreas, and gallbladder are regulated by hormones in response to food consumption. The gallbladder is a small organ that aids the liver by storing bile and concentrating bile salts.
The intestinal flora in the human gut are able to extract some nutrition from these plant fibers. Greater amounts of food energy taken in than the body’s requirements will result in storage of the excess in fat deposits. The goal of this campaign is to educate parents and caregivers on providing healthy nutrition and encouraging active lifestyles in future generations. Food intake in more than necessary amounts is stored as glycogen in the liver and muscle cells, and in adipose tissue.
The laboratory plays an essential role in the rapid diagnosis of acute pancreatitis allowing clinicians to make appropriate therapeutic decisions. Its clinical significance lies in the fact that the hyperamylasemia or macroamylasemia may lead to misinterpretations in the differential diagnosis of abdominal distress. I pray for you Dr Lusanda go God will give you everlasting life, you shall not die before your time for being a sincere and great men. Gallbladder removal surgery is one of the most common surgeries, and it is primarily performed on women. Animals must convert these macromolecules into the simple molecules required for maintaining cellular function. Using peristalsis, or wave-like smooth-muscle contractions, the muscles of the esophagus push the food toward the stomach. The peristaltic movement of the esophagus is an involuntary reflex; it takes place in response to the act of swallowing.
Acid reflux or “heartburn” occurs when the acidic digestive juices escape into the esophagus. The epithelial cells of these structures absorb nutrients from the digested food and release them to the bloodstream on the other side. Bile is produced in the liver and stored and concentrated in the gallbladder; it enters the duodenum through the bile duct. The colon is home to many bacteria or “intestinal flora” that aid in the digestive processes. This program aims to involve the entire community, including parents, teachers, and healthcare providers to ensure that children have access to healthy foods—more fruits, vegetables, and whole grains—and consume fewer calories from processed foods. There was no personal or family history of pancreatitis, cholelithiasis, or hyperlipidemia. This statistic reminds me of fibromyalgia, where 90% of diagnosed are women, chronic fatigue syndrome, lupus, hypothyroidism, irritable bowel syndrome, rheumatoid arthritis, recurrent migranes, osteoporosis, skin disorders like eczema and rosacea, and the list goes on with diseases mostly diagnosed on women!My next topic series is going to cover women’s hormonal health issues, and the diseases that are diagnosed primarily on women. The conversion of the food consumed to the nutrients required is a multistep process involving digestion and absorption. The chewing and wetting action provided by the teeth and saliva prepare the food into a mass called the bolus for swallowing. The villi and microvilli, with their many folds, increase the surface area of the small intestine and increase absorption efficiency of the nutrients.
The colon has four regions, the ascending colon, the transverse colon, the descending colon and the sigmoid colon. The excess sugars in the body are converted into glycogen and stored for later use in the liver and muscle tissue.
Minerals perform many functions, from muscle and nerve function, to acting as enzyme cofactors. During digestion, food particles are broken down to smaller components, which are later absorbed by the body. This acidity kills microorganisms, breaks down food tissues, and activates digestive enzymes.
The movement of chyme from the stomach into the small intestine is regulated by hormones, stomach distension and muscular reflexes that influence the pyloric sphincter. The monosaccharides, amino acids, bile salts, vitamins, and other nutrients are absorbed by the cells of the intestinal lining.
The main functions of the colon are to extract the water and mineral salts from undigested food, and to store waste material.
Glycogen stores are used to fuel prolonged exertions, such as long-distance running, and to provide energy during food shortage. With the increase in television viewing and stationary pursuits such as video games, sedentary lifestyles have become the norm. Further breakdown of food takes place in the small intestine where bile produced by the liver, and enzymes produced by the small intestine and the pancreas, continue the process of digestion. The large intestine reabsorbs water from the undigested food and stores waste until elimination. The smaller molecules are absorbed into the blood stream through the epithelial cells lining the walls of the small intestine.
The human body can synthesize only 11 of the 20 required amino acids; the rest must be obtained from food. X-ray examination showed no air under the diaphragms, and there was no evidence of pleural effusion.
The waste material travels on to the large intestine where water is absorbed and the drier waste material is compacted into feces; it is stored until it is excreted through the anus. The epiglottis is a flap of tissue that covers the tracheal opening during swallowing to prevent food from entering the lungs.



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