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Deflazacort is a glucocorticoid derived from prednisolone and 6 mg or 30 mg of deflazacort (Flantadin (Calcort)) has approximately the same anti-inflammatory potency as 5mg prednisolone or prednisone. The dosage should be individually titrated according to diagnosis, severity of disease and patient response and tolerance. Other conditions: The dose of deflazacort (Flantadin (Calcort)) depends on clinical need titrated to the lowest effective dose for maintenance.
In patients with hepatic impairment, blood levels of deflazacort (Flantadin (Calcort)) may be increased. In renally impaired patients, no special precautions other than those usually adopted in patients receiving glucocorticoid therapy are necessary. In elderly patients, no special precautions other than those usually adopted in patients receiving glucocorticoid therapy are necessary.
There has been limited exposure of children to deflazacort (Flantadin (Calcort)) in clinical trials. In children, the indications for glucocorticoids are the same as for adults, but it is important that the lowest effective dosage is used.
In patients who have received more than physiological doses of systemic corticosteroids (approximately 9mg per day or equivalent) for greater than 3 weeks, withdrawal should not be abrupt.
Abrupt withdrawal of systemic corticosteroid treatment, which has continued up to 3 weeks is appropriate if it is considered that the disease is unlikely to relapse. Patients with rare hereditary problems of galactose intolerance, the Lapp lactose deficiency or glucose-galactose malabsorption should not take this medicine. Undesirable effects may be minimised by using the lowest effective dose for the minimum period, and by administering the daily requirement as a single morning dose or whenever possible as a single morning dose on alternate days. Adrenal cortical atrophy develops during prolonged therapy and may persist for years after stopping treatment.
Patients should carry 'Steroid treatment' cards which give clear guidance on the precautions to be taken to minimise risk and which provide details of prescriber, drug, dosage and the duration of treatment. Suppression of the inflammatory response and immune function increases the susceptibility to infections and their severity. Chickenpox is of particular concern since this normally minor illness may be fatal in immunosuppressed patients. Patients should be advised to take particular care to avoid exposure to measles and to seek immediate medical advice if exposure occurs. Prolonged use of glucocorticoids may produce posterior subcapsular cataracts, glaucoma with possible damage to the optic nerves and may enhance the establishment of secondary ocular infections due to fungi or viruses.
Use in active tuberculosis should be restricted to those cases of fulminating and disseminated tuberculosis in which deflazacort (Flantadin (Calcort)) is used for management with appropriate antituberculosis regimen. Particular care is required when considering the use of systemic corticosteroids in patients with existing or previous history of severe affective disorders in themselves or in their first degree relatives. Glucocorticoids are known to cause irregular menstruation and leukocytosis, care should be taken with deflazacort (Flantadin (Calcort)).
Corticosteroids cause dose-related growth retardation in infancy, childhood and adolescence which may be irreversible.
The common adverse effects of systemic corticosteroids may be associated with more serious consequences in old age, especially osteoporosis, hypertension, hypokalaemia, diabetes, susceptibility to infection and thinning of the skin. The desired effects of hypoglycaemic agents (including insulin), anti-hypertensives and diuretics are antagonised by corticosteroids and the hypokalaemic effects of acetazolamide, loop diuretics, thiazide diuretics, beta 2-agonists, xanthines and carbenoxolone are enhanced. The efficacy of coumarin anticoagulants may be enhanced by concurrent corticosteroid therapy and close monitoring of the INR or prothrombin time is required to avoid spontaneous bleeding. In patients treated with systemic corticosteroids, use of non-depolarising muscle relaxants can result in prolonged relaxation and acute myopathy. The renal clearance of salicylates is increased by corticosteroids and steroid withdrawal may result in salicylate intoxication.
As glucocorticoids can suppress the normal responses of the body to attack by micro-organisms, it is important to ensure that any anti-infective therapy is effective and it is recommended to monitor patients closely. The ability of corticosteroids to cross the placenta varies between individual drugs, however, deflazacort (Flantadin (Calcort)) does cross the placenta. Administration of corticosteroids to pregnant animals can cause abnormalities of foetal development including cleft palate, intra-uterine growth retardation and effects on brain growth and development.
Corticosteroids are excreted in breast milk, although no data are available for deflazacort (Flantadin (Calcort)).
On the basis of the pharmacodynamic profile and reported adverse events, it is unlikely that deflazacort (Flantadin (Calcort)) will produce an effect on the ability to drive and use machines. The incidence of predictable undesirable effects, including hypothalamic-pituitary-adrenal suppression correlates with the relative potency of the drug, dosage, timing of administration and the duration of treatment (see Warnings and Precautions). Uncommon: Suppression of the hypothalamic-pituitary-adrenal axis, amenorrhoea, Cushingoid facies.
Uncommon: impaired carbohydrate tolerance with increased requirement for anti-diabetic therapy, sodium and water retention with hypertension, potassium loss and hypokalaemic alkalosis when coadministered with beta 2-agonist and xanthines. Uncommon: Increased susceptibility and severity of infections with suppression of clinical symptoms and signs, opportunistic infections, recurrence of dormant tuberculosis (see Warnings and Precautions). Not known: restlessness, Increased intra-cranial pressure with papilloedema in children (pseudotumour cerebri), usually after treatment withdrawal, aggravation of epilepsy.

Not known: anxiety, sleep disturbances, and cognitive dysfunction including confusion and amnesia have been reported. Not known: Increased intra-ocular pressure, glaucoma, papilloedema, posterior subcapsular cataracts especially in children, corneal or scleral thinning, exacerbation of ophthalmic viral or fungal diseases.
Not known: perforation of peptic ulcer, acute pancreatitis (especially in children), candidiasis. Not known: Too rapid a reduction of corticosteroid dosage following prolonged treatment can lead to acute adrenal insufficiency, hypotension and death (see Warnings and Precautions).
A 'withdrawal syndrome' may also occur including fever, myalgia, arthralgia, rhinitis, conjunctivitis, painful itchy skin nodules and loss of weight.
Reporting suspected adverse reactions after authorisation of the medicinal product is important. Orally administered deflazacort (Flantadin (Calcort)) appears to be well absorbed and is immediately converted by plasma esterases to the pharmacologically active metabolite (D 21-OH) which achieves peak plasma concentrations in 1.5 to 2 hours. Deflazacort is packed in blister packs of polyvinylchloride and aluminium foil presented in cardboard cartons.
Properties: Analgesic, anti-fungal, anti-inflammatory, anti-oxidant, antiseptic, digestive, diuretic, sedative, tonic. Benefits: Blemishes, colds, coughs, dry skin, nervousness, scars, skin ailments, stress, ulcers, wrinkles, and wounds. Blends Well With: Bergamot, black pepper, camphor, cardamom, cypress, geranium, lavender, lemon, patchouli, rose, sandalwood.
Star Anise has been used in traditional Chinese medicine for over thousand years for its stimulating effect on the digestive system such as stomach discomfort, indigestion and bloating, as well as for respiratory ailments including bronchitis and unproductive coughs. General medicinal properties: Star Anise has been used in traditional Chinese medicine for over thousand years for its stimulating effect on the digestive system such as stomach discomfort, indigestion and bloating, as well as for respiratory ailments including bronchitis and unproductive coughs.
Blends well with bay, cardamom, caraway, coriander, cedarwood, dill, sweet fennel, lavender, mandarin, neroli, orange, petitgrain, rosewood. Caution: Applying undiluted oil on skin can cause irritation, always use in low concentration and may cause skin sensitisations and Do not use during pregnancy. Did you know that raspberry ketone is not only found in raspberries as the name suggests but is also naturally found in cranberries and blackberries?
Raspberry ketone is a member of the group of compounds known as polyphenols and has been used for many years as a natural flavour in the food industry. Each Natures Aid Raspberry Ketone capsule provides 400mg of Pure Raspberry Ketonewith 35mg of Green Tea standardised to provide 95% Polyphenols.Artificial Flavours.
Raspberry Ketones, Cellulose, Green Tea Leaf Extract, Anticaking Agent (Vegetable Source Magnesium Stearate). This condition occurs when the skin no longer represents a defensive barrier and the bacteria easily disseminate into the body.
In more serious and life-threatening conditions, high doses of deflazacort (Flantadin (Calcort)) may need to be given.
The lowest dose that will produce an acceptable response should be used (see Warnings and Precautions). For maintenance in chronic asthma, doses should be titrated to the lowest dose that controls symptoms. Starting doses may be estimated on the basis of ratio of 5mg prednisone or prednisolone to 6 mg or 30 mg deflazacort (Flantadin (Calcort)).
Therefore the dose of deflazacort (Flantadin (Calcort)) should be carefully monitored and adjusted to the minimum effective dose. The common adverse effects of systemic corticosteroids may be associated with more serious consequences in old age (see Warnings and Precautions). How dose reduction should be carried out depends largely on whether the disease is likely to relapse as the dose of systemic corticosteroids is reduced.
Abrupt withdrawal of doses up to 48 mg daily of deflazacort (Flantadin (Calcort)), or equivalent for 3 weeks is unlikely to lead to clinically relevant HPA-axis suppression, in the majority of patients. Frequent patient review is required to appropriately titrate the dose against disease activity (see Dosage section). Withdrawal of corticosteroids after prolonged therapy must therefore always be gradual to avoid acute adrenal insufficiency which could be fatal, being tapered off over weeks or months according to the dose and duration of treatment. The clinical presentation may often be atypical and serious infections such as septicaemia and tuberculosis may be masked and may reach an advanced stage before being recognised. Patients (or parents of children) without a definite history of chicken pox should be advised to avoid close personal contact with chickenpox or herpes zoster and, if exposed, they should seek urgent medical attention. If glucocorticoids are indicated in patients with latent tuberculosis or tuberculin reactivity, close observation is necessary as reactivation of the disease may occur. The risk of such reactions may be increased by coadministration of quinolones (see section 4.8 undesirable effects). Risk factors for this include prolonged and high dose corticosteroid treatment, and prolonged duration of muscle paralysis. Concurrent use of glucocorticoids and oral contraceptives should be closely monitored as plasma levels of glucocorticoids may be increased. Doses of up to 50 mg daily of deflazacort (Flantadin (Calcort)) are unlikely to cause systemic effects in the infant.

Its anti-inflammatory and immunosuppressive effects are used in treating a variety of diseases and are comparable to other anti-inflammatory steroids.
It is 40% protein-bound and has no affinity for corticosteroid-binding-globulin (transcortin).
Star Anise is also useful in dyspepsia, flatulence, spasmodic, dysentery, asthma, hemiplegia, facial paralysis and halitosis. Natures Aid Raspberry Ketone Advance+ provides 400mg of raspberry ketones and 35mg of added green tea to provide optimum polyphenol levels. It is also known by the impressive chemical name 4-(4-Hydroxyphenyl) butan-2-one and the much more fragrant name frambinone.
The people who are most at risk of developing this skin condition are those who are critically ill or those whose immune system is severely compromised. What happens is that pseudomonas aeruginosa enters the body and affects the arteries and veins in the skin, causing their walls to be inflamed and quickly leading to necrosis. It is important to know the kind of pathogen that is causing the infection in order to administer the right treatment. When deflazacort (Flantadin (Calcort)) is used long term in relatively benign chronic diseases, the maintenance dose should be kept as low as possible. During prolonged therapy, any intercurrent illness, trauma or surgical procedure will require a temporary increase in dosage; if corticosteroids have been stopped following prolonged therapy, they may need to be temporarily re-introduced. Passive immunisation with varicella zoster immunoglobulin (VZIG) is needed by exposed non-immune patients who are receiving systemic corticosteroids or who have used them within the previous 3 months; this should be given within 10 days of exposure to chickenpox. It is recommended to increase the maintenance dose of deflazacort (Flantadin (Calcort)) if drugs which are liver enzyme inducers are co-administered, e.g. This interaction is more likely following prolonged ventilation (such as in the ITU setting).
However, when administered for prolonged periods or repeatedly during pregnancy, corticosteroids may increase the risk of intra-uterine growth retardation. Infants of mothers taking higher doses than this may have a degree of adrenal suppression but the benefits of breast feeding are likely to outweigh any theoretical risk.
Psychological effects have been reported on withdrawal of corticosteroids; the frequency is unknown. Teratogenic effects demonstrated in rodents and rabbits are typical of those caused by other glucocorticoids. Getty Images reserves the right to pursue unauthorized users of this image or clip, and to seek damages for copyright violations. In many of these patients, this condition is a sign of generalized infection in the body (with the same pathological agent). The affectation of the blood vessels leads to secondary necrosis in the other layers of the skin, contributing to the aggravation of the disease. If the disease is unlikely to relapse on withdrawal of systemic corticosteroids but there is uncertainty about HPA suppression, the dose of systemic corticosteroids may be reduced rapidly to physiological doses. If a diagnosis of chickenpox is confirmed, the illness warrants specialist care and urgent treatment.
Most reactions recover after either dose reduction or withdrawal, although specific treatment may be necessary.
Antacids may reduce bioavailability; leave at least 2 hours between administration of deflazacort (Flantadin (Calcort)) and antacids.
Hypoadrenalism may, in theory, occur in the neonate following prenatal exposure to corticosteroids but usually resolves spontaneously following birth and is rarely clinically important. Elimination takes place primarily through the kidneys; 70% of the administered dose is excreted in the urine. Deflazacort was not found to be carcinogenic in the mouse, but studies in the rat produced carcinogenic findings consistent with the findings with other glucocorticoids. Ecthyma gangrenosum is mainly characterized by the appearance of lesions in the skin in the form of vesicles or pustules. This condition has a high mortality rate, especially if emergency medical treatment is not administered. Once a daily dose equivalent to 9mg deflazacort (Flantadin (Calcort)) is reached, dose reduction should be slower to allow the HPA-axis to recover. As with all drugs, corticosteroids should only be prescribed when the benefits to the mother and child outweigh the risks. There is no prevalence whereas the gender is concerned and, when it comes to age, it seems that children and the elderly are the most affected (as their immune system does not function properly).
When corticosteroids are essential however, patients with normal pregnancies may be treated as though they were in the non-gravid state. The metabolite of D 21-OH, deflazacort (Flantadin (Calcort)) 6-beta-OH, represents one third of the urinary elimination. Create your slideshowBy using the code above and embedding this image, you consent to Getty Images' Terms of Use.

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