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Many people want to live a long-healthy lives, but what does it take to stay fit and healthy? Amazingly, in 1900s, Noble Prize-winning Eli Metchnikoff hypothesized long, healthy lives of Bulgarian peasants were due to their consumption of fermented milk products.  These fermented products such as yogurt are referred to as probiotics, which contain beneficial bacteria that protect the “gut” from the harmful bacteria. Probiotics literally means ‘for life’, are micro-organisms such as bacteria that have health benefits in humans. Goal of the study: To identify genes whose expression patterns are altered in the stationary phase in comparison to the late logarithmic phase. During stationary phase, where there is depletion of nutrient (glucose), there are certain genes that are up-regulated while others are down-regulated.
In the stationary phase, there are 87 differentially expressed genes in the stationary phase compared to the exponential phase.  Of the 87 genes, 61 of them are up-regulated and 26 are down-regulated.
Several of the up-regulated genes are involved in carbon metabolism and energy production.  These up-regulated genes encode for transcription, inorganic ion transport, chaperones, and proteins.
Genes that are down-regulated are those that encode for nucleotide transport and metabolism, inorganic ion transport and metabolism, and energy production and conversion. A good approach in understanding the way L.casei Zhang grows and survives in the late stage of milk fermentation, is to know the effects of glucose depletion on the transcriptome. Understanding which genes are up-regulated and down-regulated during the stationary phase can influence the ability of the probiotic to survive in the product during storage and it can also have economical benefit in industrial applications. Phagocytic receptor signaling regulates clathrin and epsin-mediated cytoskeletal remodeling during apoptotic cell engulfment in C. Recent investigations and legal actions by flight crews are showing that the cabin air in planes may may be polluted with toxic organophosphates.
Natural Health News — The addition of a simple probiotic to the diets of patients with RA could help reduce inflammation and pain. Rheumatoid arthritis (RA) is a disease characterised by chronic inflammation of the joints with eventual destruction of cartilage and bone.
There is no long-term treatment that provides consistent relief without adverse effects and so there is a real need for safe and effective alternatives. To determine if probiotic treatment could help support typical treatment procedures, Beitullah Iranian researchers at Tabriz University of Medical Sciences performed a small double-blind, placebo-controlled trial to assess the effects of supplementation on 46 women with established rheumatoid arthritis.
The patients in the probiotic group received a daily capsule that contained a minimum of 108 (one hundred million) colony-forming units of Lactobacillus casei 01 for 8 weeks. The women supplemented with probiotics experienced significant improvements in clinical symptoms such as tender and swollen joints, and immune parameters such as levels of inflammatory substances called cytokines. Laboratory tests shows that levels of anti-inflammatory cytokine (interleukin-10) was increased by supplementation while levels of pro-inflammatory cytokines (tumor necrosis factor-?, interleukin-6, and interleukin-12) significantly decreased in the probiotic group.


The length of time for the expiration date or "best used before" date depends on the type of product, as well as the brand. Perishable items (such as flax oils or certain probiotics) generally have shorter expiration dates. Our receiving department does its best to verify and then enter the correct expiration dates for all incoming products. The Shipping Weight includes the product, protective packaging material and the actual shipping box.
Supporting kids' natural defense systems is important to promoting their overall health as well as helping to alleviate occasional digestive distress. Culturelle Kids Chewables contains Lactobacillus GG, the most clinically studied probiotic strain‡. The Lactobacillus GG strain (Lactobacillus rhamnosus GG-ATCC 53103) was discovered in 1985 at Tufts University in Boston, MA. Xylitol, sucrose, microcrystalline cellulose, stearic acid, vegetable juice (color), maltodextrin, sodium ascorbate, natural berry flavor, magnesium stearate, citric acid, malic acid, silica. Contains none of the following: synthetic colors, preservatives, dairy, lactose, milk, yeast, gluten or soy. Become an iHerb customer and earn unlimited Rewards by sharing your favorite iHerb products with others.
Because Lactobacillus reuteri naturally occurs in the human body it is uniquely adapted to reside in humans.
The benefits of Probiotics in the treatment and management of people with periodontal disease is evidenced in the scientific literature as a adjunct to clinical treatment. Filler (Isomalt), Lactobacillus reuteri DSM 17938 and Lactobacillus reuteri ATCC PTA 5289 (Lactobacillus reuteri Prodentis), hydrogenated palm oil, peppermint flavour, menthol flavour, peppermint oil and sweetener (sucralose).
Supplementation with Lactobacillus reuteri Prodentis affects the oral microbiota locally by competing for binding sites and nutrients with pathogenic bacteria. Please contact us via one of the methods below, if we are unavailable please be patient and someone will get back to you as soon as possible. Fermentation is the process where, in the absence of oxygen, a glucose molecule or other carbohydrate sources are converted into cellular energy and the metabolite lactate.
The bacteria start to grow at the time of 3h and grow from the logarithmic phase into the stationary phase at the time of ~16h.
Sufferers are often in constant pain and the disease, which gains severity with an imbalance between the levels of pro-inflammatory and anti-inflammatory cytokines, has a often devastating impact on quality of life. Although our warehouse is fully air-conditioned, these more fragile items are put in cold storage (freezer or refrigeration unit) for maximum freshness.


Culturelle Kids Chewables support a child's health by fostering the proper balance between good bacteria and the non-beneficial bacteria that resides in the gastrointestinal tract. It is demonstrated to survive harsh stomach acids to get where it's needed most in the intestines and is recognized as safe for regular use.
Considered the premier probiotic in the world, Lactobacillus GG has been the subject of over 800 scientific studies.
In addition, Lactobacillus reuteri Prodentis produces reuterin which directly inhibits growth of pathogenic bacteria. Lactobacillus reuteri Prodentis does not only suppress the emergence of endogenous pathogens and prevent the superinfection with exogenous pathogens, but might also protect the host by stimulating the immune system, which is done by modulating the inflammatory process via T cells and cytokines. During fermentation, there was gradual decrease in pH in the fermented milk which could be explained by sugar in milk being converted into lactic acid by L.casei cells. Gene expression profile of probiotic Lactobacillus casei Zhang during the late stage of milk fermentation. This being said, the exceptionally high turnover at iHerb ensures that our inventory is among the freshest in the industry. Research has shown that Lactobacillus GG alleviates occasional digestive distress while supporting a child's natural defenses. Unlike some products which measure the number of probiotic cultures at time of manufacture, Culturelle guarantees the stated number of live naturally sourced Lactobacillus GG cultures through the expiration date on the package.
From a therapeutic perspective, it is important that probiotics are ingested daily since Lactobacillus reuteri Prodentis does not colonize the oral cavity or digestive tract permanently.
According to the authors the results are similar to those of other adjuncts to treatment of periodontitis, such as systemic antibiotics.
This product should not be used by those with immune problems unless directed by a physician.
Let the lozenge slowly melt in your mouth, preferably after tooth brushing and interdental cleaning. This product should not be used as a substitute for a varied diet. Helps in the relief of anxiety and depression (enzymes play a huge role in gut-serotonin production!). As such, these products will reflect a higher Shipping Weight compared to the unprotected product.
Reduces symptoms of lactose intolerance- breaks down sugars, starches, and lactose for easier digestion.  Most importantly, it keeps your digestive system fit and active!



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