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The protein part of nucleoprotein is acted upon by proteolytic enzymes of gastric and intestinal juices.
Generally the metacarpal phalangeal joints and metatarsal phalangeal joints are affected by this gout. Whenever there is cell death, the nucleic acids are released and converted to purines and finally uric acid is formed.
Enteroendocrine cells include G-cells, which produce gastrin, enterochromaffin-like cells (ECLs), which produce histamine, and others that produce somatostatin and serotonin. Mucous neck cells produce a thin, watery, acidic mucus, the purpose of which is an ongoing area of investigation. The plicae circulares are circular folds of mucosa and submucosa that impart a spiral movement to chyme, allowing more mixing with intestinal secretions and greater absorption.
Microvilli (the brush border) are projections from the apical surface of each epithelial cell which further increase the surface area for absorption and also contain enzymes (brush border enzymes) that complete digestion of nutrients. The submucosa contains Peyer's patches, aggregated lymph nodules (MALT), which increase in number along the length of the small intestine (there are more in the large intestine).
The submucosa also contains duodenal glands (Brunner's glands), which secrete alkaline mucus to raise the pH and protect the wall of the duodenum. There are no modifications for absorption like in the small intestine and no cells that produce digestive enzymes. Haustral contractions are slow contractions that occur about every 30 minutes and last approximately 1 minute. Mass movements are long, slow moving, powerful contractions that move over the colon 3 or 4 times per day, typically after meals. In addition to these movements some segmentation occurs in the descending and sigmoid colon to increase water absorption before mass movements propel the feces into the rectum.


These nucleic acids are not utilized by the body; instead they are digested, catabolized and excreted. Nucleic acids are acted upon by nucleases (ribonuclease and deoxyribonuclease) of pancreatic and intestinal juices to produce mononucleotides. In lower animals, birds and reptiles, uric acid is converted to allantoin by the action of enzyme uricase. Uricosuric drugs like salicylates, cinchopher, adrenal cortical hormones, which cause increased excretion of uric acid in urine by decreasing its re-absorption. Allopurinol (Allantoin) a structural analogue to hypoxanthine which competitively inhibits xanthine oxidase and decreases the production of uric acid. The HMP shunt pathway is overactive due to the deficiency of glucose-6-phosphatase thereby producing excessive amounts of ribose-5-phosphate.
The products of breakdown of pyrimidine ring are ammonia and CO2 which are converted into urea for excretion. The villi have capillaries and lacteals in the lamina propria for nutrient absorption (most dietary fat is absorbed by the lacteals, specialized lymphatic capillaries). Paneth cells deep in the crypts secrete lysozyme, an enzyme that degrades bacterial cell walls. Distension or irritation of the mucosa by hypotonic or acidic chyme stimulates the release of intestinal juice, around 1 - 2 liters per day. Bacteria also produce biotin and vitamin K, which are absorbed through the intestinal wall.
This gastrocolic reflex accompanies the gastroileal reflex stimulated by gastrin release when the stomach recieves food. They are taken in the form of nucleoproteins, which are conjugated proteins with amino acids constituting the protein part and nucleic acids constituting the prosthetic part.


Nucleotides are hydrolysed to nucleosides by nucleotidases (intestinal phosphatase) Nucleosides are absorbed by intestinal mucosa to portal blood and transported to the liver and supplied through systemic circulation to other viscera.
Liver, spleen, kidney, intestinal mucosa contain enzymes capable of acting on the purine ring in the free or combined state. The anal epithelium hangs in long folds (anal columns) in the superior portion of the anus. The enzyme nucleosides liberate the free purine and pyrimidine base and ribose or deoxyribose from the nucleosides. In the intestine it will be converted to CO2 and NH3 either by action of intestinal flora or autoxidation of the uric acid.
Because of this the tissue gets degraded or degenerated at the bone joints leading to degeneration of neighbouring tissues as well. The anal sinuses are the recesses between the anal columns; they secrete mucus when compressed by feces, which aids passage of feces out of the anus.
Uric acid concentration does not vary with greater intake of uric acid in the diet because on intake of higher concentration in the diet the synthesis of uric acid in the body will be inhibited.
Estimation of blood uric acid in ureotelic animals has importance in the diagnosis of gout and Von-Gierke’s disease.



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