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Think about all the chemical reactions that occur in our bodies within the period of a minute.
Enzymes are catalysts, which means that they speed up chemical reactions, but are not changed by the reaction.
Unfortunately, because of improper diet and the fact that heat destroys many enzymes, you may not be receiving all you need to properly support your overall health. Virtually everyone of the Life Plus products is formulated with the exclusive PhytoZyme base of phytonutrients consisting of concentrations of herbs, fruits, vegetables and plant enzymes.
Pancreas resection - A portion of a person's pancreas (or in some cases the entire pancreas) is surgically removed usually because they have a cancerous tumor.
You must have JavaScript enabled in your browser to utilize the functionality of this website. This product contains a non-acidic form of vitamin C (calcium ascorbate) and is fortified with natural bioflavonoid for maximum effectiveness.
Directions for use: As a food supplement - Adults - One capsule daily with food or as directed by a healthcare professional. Vitamin B6 also plays a big role in maintaining muscle tone along the digestive tract, maintains health of the nervous system, skin, eyes, mouth as well as the liver as do all the B vitamins. Vitamin B6 is water soluble and must be taken every day because it is not stored in the body for long periods of time for it is excreted within one to four days.
Required by the nervous system, for normal brain function, and for the synthesis of RNA and DNA, which controls cell reproduction and normal cellular growth. The toxicity of Vitamin B6 only comes from over supplementation, never from eating foods rich in B6. Symptoms include pain and numbness of the extremities and in sever cases difficulty walking.
Heel pain should be treated as soon as it is detected to prevent it from becoming permanent.
Ladies should wear high pencil heels only on special occasions and that too for short periods of time.
It relaxes the muscles and relieves heel pain. Pain relieving herbal oil that contains the extract of arnica, ginger, camphor and peppermint are very effective to treating heel pain.
Stop for 10 minutes and as you feel the heel warming up start massaging again for 10 minutes. Follow a regular exercise regime and proper diet for weight management. You can consult a dietician and a physical trainer for proper guidance to begin your weight management programme. The dose of Rytmonorm (Generic Rythmol) must be individually titrated on the basis of response and tolerance. In patients with hepatic impairment or those with significant widening of the QRS complex or second- or third-degree AV block, consider reducing the dose. As with other antiarrhythmic agents, in the elderly or in ventricular arrhythmia patients with marked previous myocardial damage, the dose of Rytmonorm (Generic Rythmol) should be increased more gradually during the initial phase of treatment. In a trial of sustained-release propafenone (Rytmonorm (Generic Rythmol) SR®), there were too few deaths to assess the long-term risk to patients. The use of Rytmonorm (Generic Rythmol) in conjunction with other drugs that prolong the QT interval has not been extensively studied.
Increased exposure to propafenone may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity. Propafenone exerts a negative inotropic activity on the myocardium as well as beta-blockade effects and may provoke overt heart failure. Propafenone slows atrioventricular conduction and may also cause dose-related first-degree AV block.
Propafenone may alter both pacing and sensing thresholds of implanted pacemakers and defibrillators. Approximately 50% of propafenone metabolites are excreted in the urine following administration of Rytmonorm (Generic Rythmol). In patients with impaired renal function, monitor for signs of overdosage [see Overdosage (10)]. Reversible disorders of spermatogenesis have been demonstrated in monkeys, dogs, and rabbits after high-dose intravenous administration of propafenone. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice. Adverse reactions associated with Rytmonorm (Generic Rythmol) occur most frequently in the gastrointestinal, cardiovascular, and central nervous systems. Adverse reactions reported for > 1.5% of 474 subjects with SVT who received Rytmonorm (Generic Rythmol) in US clinical trials are presented in Table 1 by incidence and percent discontinuation, reported to the nearest percent. Adverse reactions reported for ?1% of 2,127 subjects with ventricular arrhythmia who received propafenone in US clinical trials were evaluated by daily dose. In addition, the following adverse reactions were reported less frequently than 1% either in clinical trials or in marketing experience. Cardiovascular System: Atrial flutter, AV dissociation, cardiac arrest, flushing, hot flashes, sick sinus syndrome, sinus pause or arrest, supraventricular tachycardia.
Gastrointestinal: Cholestasis , elevated liver enzymes (alkaline phosphatase, serum transaminases), gastroenteritis, hepatitis . Hematologic: Agranulocytosis, anemia, bruising, granulocytopenia, leukopenia, purpura, thrombocytopenia. The following adverse reactions have been identified during post-approval use of Rytmonorm (Generic Rythmol). Gastrointestinal: A number of patients with liver abnormalities associated with propafenone therapy have been reported in postmarketing experience. Drugs that inhibit CYP2D6 (such as desipramine, paroxetine, ritonavir, or sertraline) and CYP3A4 (such as ketoconazole, ritonavir, saquinavir, erythromycin, or grapefruit juice) can be expected to cause increased plasma levels of propafenone.
Amiodarone: Concomitant administration of propafenone and amiodarone can affect conduction and repolarization and is not recommended. Cimetidine: Concomitant administration of propafenone immediate-release tablets and cimetidine in 12 healthy subjects resulted in a 20% increase in steady-state plasma concentrations of propafenone.
Fluoxetine: Concomitant administration of propafenone and fluoxetine in extensive metabolizers increased the S-propafenone Cmax and AUC by 39% and 50%, respectively, and the R propafenone Cmax and AUC by 71% and 50%, respectively. Quinidine: Small doses of quinidine completely inhibit the CYP2D6 hydroxylation metabolic pathway, making all patients, in effect, slow metabolizers [see Clinical Pharmacology (12)]. Rifampin: Concomitant administration of rifampin and propafenone in extensive metabolizers decreased the plasma concentrations of propafenone by 67% with a corresponding decrease of 5-OH-propafenone by 65%. Concomitant use of propafenone and digoxin increased steady-state serum digoxin exposure (AUC) in patients by 60% to 270%, and decreased the clearance of digoxin by 31% to 67%.


The concomitant administration of propafenone and warfarin increased warfarin plasma concentrations at steady state by 39% in healthy volunteers and prolonged the prothrombin time (PT) in patients taking warfarin. Concomitant use of propafenone and propranolol in healthy subjects increased propranolol plasma concentrations at steady state by 113%.
No significant effects on the pharmacokinetics of propafenone or lidocaine have been seen following their concomitant use in patients.
It is not known whether the use of propafenone during labor or delivery has immediate or delayed adverse effects on the fetus, or whether it prolongs the duration of labor or increases the need for forceps delivery or other obstetrical intervention.
The safety and effectiveness of propafenone in pediatric patients have not been established. Clinical trials of Rytmonorm (Generic Rythmol) did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. The symptoms of overdosage may include hypotension, somnolence, bradycardia, intra-atrial and intraventricular conduction disturbances, and rarely, convulsions and high-grade ventricular arrhythmias. The hemodialysis of propafenone in patients with an overdose is expected to be of limited value in the removal of propafenone as a result of both its high protein binding (>95%) and large volume of distribution. Rytmonorm (Generic Rythmol) (propafenone hydrochloride) is an antiarrhythmic drug supplied in scored, film-coated tablets of 150 and 225 mg for oral administration. Chemically, propafenone hydrochloride (HCl) is 2’-[2-hydroxy-3-(propylamino)-propoxy]-3-phenylpropiophenone hydrochloride, with a molecular weight of 377.92. Propafenone HCl occurs as colorless crystals or white crystalline powder with a very bitter taste. Propafenone is a Class 1C antiarrhythmic drug with local anesthetic effects, and a direct stabilizing action on myocardial membranes. For example, digestive enzymes cause food that we eat to be broken down much faster than would occur without them, but they are not broken down in the reaction they are speeding up. After surgery patients may need pancreatic enzyme supplements and insulin depending on how much their body can produce with a reduced pancreas.
Mineral salts of ascorbic acid (mineral ascorbates) are buffered, and are therefore less acidic. Very high doses of Vitamin B6 may result in painful neurological symptoms know as sensory neuropathy.
Because there is little evidence that one needs more than 100 mg per day, there is no reason to exceed this amount.
Promoting Natural Health and Healing using Aromatherapy, Herbs, Vitamins, Minerals, Essential Oils, Teas, Juices and Nutritional Supplements.
It can be managed with simple home remedies that bear fruitful results if followed regularly. High heels cause unnecessary strain on calves and heels and cause pain. People suffering from heel pain can use heel pads in their shoes to support the heels. Pack some crushed ice in a plastic or cloth bag and gently massage the heel for 10-15 minutes. You accept that you are following any advice at your own risk and will properly research or consult healthcare professional. Concomitant treatment with drugs that increase the functional atrioventricular (AV) nodal refractory period is recommended.
Such proarrhythmic effects include sudden death and life-threatening ventricular arrhythmias such as ventricular fibrillation, ventricular tachycardia, asystole, and torsade de pointes. Perform an ECG after initiation of Rytmonorm (Generic Rythmol), and discontinue the drug if changes are suggestive of Brugada Syndrome [see Contraindications (4)]. Such drugs may include many antiarrhythmics, some phenothiazines, tricyclic antidepressants, and oral macrolides. Approximately 6% of Caucasians in the US population are naturally deficient in CYP2D6 activity and to a somewhat lesser extent in other demographic groups.
Of the subjects with CHF probably related to propafenone, 80% had pre-existing heart failure and 85% had coronary artery disease. Development of second- or third-degree AV block requires a reduction in dosage or discontinuation of propafenone HCl.
Generally, the agranulocytosis occurred within the first 2 months of propafenone therapy and upon discontinuation of therapy; the white count usually normalized by 14 days. Severe liver dysfunction increases the bioavailability of propafenone to approximately 70% compared with 3% to 40% in patients with normal liver function. They have been reversible upon cessation of treatment and may disappear even in the face of continued propafenone therapy. Evaluation of the effects of short-term administration of Rytmonorm (Generic Rythmol) on spermatogenesis in 11 normal subjects suggested that propafenone produced a reversible, short-term drop (within normal range) in sperm count. About 20% of subjects treated with Rytmonorm (Generic Rythmol) have discontinued treatment because of adverse reactions.
Causality and relationship to propafenone therapy cannot necessarily be judged from these events. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Some appeared due to hepatocellular injury, some were cholestatic, and some showed a mixed picture.
Concomitant administration of quinidine (50 mg 3 times daily) with 150 mg immediate-release propafenone 3 times daily decreased the clearance of propafenone by 60% in extensive metabolizers, making them slow metabolizers.
Monitor plasma digoxin levels of patients receiving propafenone and adjust digoxin dosage as needed. In postmarketing reports, abrupt cessation of orlistat in patients stabilized on propafenone has resulted in severe adverse events including convulsions, atrioventricular block, and acute circulatory failure. In 4 patients, administration of metoprolol with propafenone increased the metoprolol plasma concentrations at steady state by 100% to 400%. However, concomitant use of propafenone and lidocaine has been reported to increase the risks of central nervous system side effects of lidocaine. Because of the potential for serious adverse reactions in nursing infants from propafenone, decide whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Other reported clinical experience has not identified differences in responses between the elderly and younger subjects. Defibrillation, as well as infusion of dopamine and isoproterenol have been effective in controlling abnormal rhythm and blood pressure.
The electrophysiological effect of propafenone manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential.
After two hours or more in the stomach, the partly digested food moves into the beginning of the duodenum.


This form of vitamin C is more suitable for people who experience gastro-intestinal problems or for those who wish to supplement larger doses of vitamin C. However, there have been some cases of individuals who developed these symptoms with doses of 500 mg per day. For walking or jogging you should always wear sports shoes which have shock absorbing qualities. It may also worsen premature ventricular contractions or supraventricular arrhythmias, and it may prolong the QT interval. Six of the 9 subjects that developed ventricular arrhythmias did so within 14 days of onset of therapy. The incidence of proarrhythmia in subjects with less serious or benign arrhythmias, which include subjects with an increase in frequency of PVCs, was 1.6%.
Withhold Class IA and III antiarrhythmic agents for at least 5 half-lives prior to dosing with Rytmonorm (Generic Rythmol).
Therefore, avoid simultaneous use of Rytmonorm (Generic Rythmol) with both a CYP2D6 inhibitor and a CYP3A4 inhibitor.
Do not give propafenone to patients with atrioventricular and intraventricular conduction defects in the absence of a pacemaker [see Contraindications (4), Clinical Pharmacology (12.2)].
Unexplained fever or decrease in white cell count, particularly during the initial 3 months of therapy, warrant consideration of possible agranulocytosis or granulocytopenia.
In 8 subjects with moderate to severe liver disease, the mean half-life was approximately 9 hours. These laboratory findings were usually not associated with clinical symptoms, but there is one published case of drug-induced lupus erythematosis (positive rechallenge); it resolved completely upon discontinuation of therapy. Other reactions reported more frequently than on placebo or comparator and not already reported elsewhere included anxiety, angina, second-degree AV block, bundle branch block, loss of balance, congestive heart failure, and dyspepsia. Some less common reactions may also have been dose-related such as first-degree AV block, congestive heart failure, dyspepsia, and weakness. Some of these reports were simply discovered through clinical chemistries, others because of clinical symptoms including fulminant hepatitis and death. Therefore, simultaneous use of Rytmonorm (Generic Rythmol) with both a CYP2D6 inhibitor and a CYP3A4 inhibitor should be avoided [see Warnings and Precautions (5.4), Dosage and Administration (2)].
Steady-state plasma concentrations more than doubled for propafenone, and decreased 50% for 5-OH-propafenone. In slow metabolizers, there was a 50% decrease in propafenone plasma concentrations and an increase in the AUC and Cmax of norpropafenone by 74% and 20%, respectively. The pharmacokinetics of propafenone was not affected by the coadministration of either propranolol or metoprolol. Rytmonorm (Generic Rythmol) should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. The following inactive ingredients are contained in the tablet: corn starch, hypromellose, magnesium stearate, polyethylene glycol, polysorbate, povidone, propylene glycol, sodium starch glycolate, and titanium dioxide. In Purkinje fibers, and to a lesser extent myocardial fibers, propafenone reduces the fast inward current carried by sodium ions. In clinical trials, resting heart rate decreases of about 8% were noted at the higher end of the therapeutic plasma concentration range. When the food reaches the duodenum, the pancreas releases its digestive juices which flow down the pancreatic duct and mix with the food. You can use sesame oil for massage as it has the ability to warm up the area and penetrates easily in to the skin. It is therefore essential that each patient given Rytmonorm (Generic Rythmol) be evaluated electrocardiographically prior to and during therapy to determine whether the response to Rytmonorm (Generic Rythmol) supports continued treatment.
Although most proarrhythmic events occurred during the first week of therapy, late events also were seen and the CAST trial [see Boxed Warning: Mortality] suggests that an increased risk of proarrythmia is present throughout treatment.
Avoid the use of propafenone with Class IA and III antiarrhythmic agents (including quinidine and amiodarone). Instruct patients to report promptly any signs of infection such as fever, sore throat, or chills.
Increased bioavailability of propafenone in these patients may result in excessive accumulation.
Carefully evaluate patients who develop an abnormal ANA test and, if persistent or worsening elevation of ANA titers is detected, consider discontinuing therapy. Other adverse reactions included rash, syncope, chest pain, abdominal pain, ataxia, and hypotension. In clinical trials using propafenone immediate-release tablets, subjects who were receiving beta-blockers concurrently did not experience an increased incidence of side effects.
General supportive measures such as mechanical respiratory assistance and external cardiac massage may be necessary. At very high concentrations in vitro, propafenone can inhibit the slow inward current carried by calcium, but this calcium antagonist effect probably does not contribute to antiarrhythmic efficacy.
Home Remedy Central has not been evaluated by the Food and Drug Administration and should not be used to prescribe, diagnose, treat, cure, or prevent any disease or illness. It helps to stretch the entire muscles of the foot and relieves heel pain. In case of severe pain do the exercise gently and for a lesser period of time. Because propafenone prolongs the QRS interval in the electrocardiogram, changes in the QT interval are difficult to interpret [see Clinical Pharmacology (12.2)]. There is only limited experience with the concomitant use of Class IB or IC antiarrhythmics. Experience in patients with sick sinus node syndrome is limited and these patients should not be treated with propafenone. Carefully monitor patients with impaired hepatic function for excessive pharmacological effects [see Overdosage (10)].
Similar results were noted in elderly patients: Both the AUC and Cmax of propafenone decreased by 84%, with a corresponding decrease in AUC and Cmax of 5-OH?propafenone by 69% and 57%, respectively.
Home Remedy Central does not represent or endorse the accuracy or reliability of the natural remedies listed. Always consult with your doctor or medical professional with any questions you have regarding health concerns.



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