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Digestive enzymes are not only great for internal health, they’re also great for healthy skin, nails, and hair. When applied topically to the skin, enzymes break up dead lack luster surface cells to reveal healthier skin cells. Bromelain and papain are enzymes found in fruits, often used in cosmetic products like masks and serums to clarify the skin and soften lines and wrinkles.
Tryptophan first became available in healthfood stores nearly forty years ago, but even a quarter of a century later little work had been done to answer that question. About ten year ago, Lidtke received a purchase order from an African nation for tryptophan.
We knew that inflammation, infection, poor genetics, and dietary deficiencies can block your bodya€™s use of amino acids, including tryptophan. Just as explorers map trails through the wilderness, medical researchers map the biochemical trails (pathways) that amino acids follow while building health in your body. These enzymes are the product of your individual genetics, and some may work better in one person than in another.
Without these helpers, your most important biochemical pathways may work poorly or become a dead end, forcing the production of undesirable waste products that provoke side effects or produce disease. Since the 1990a€™s, scientists have known that infections have the potential to interfere with tryptophan metabolism. What this demonstrated, though, was that your own immune system can play a detrimental role in brain health.
At this point, researchers report that one or both of these two brain chemicals, kynurenine and quinolinic acid, may act directly on serotonin and depress levels even further. By this series of steps, then, infection, allergies, or toxins may activate your immune system to produce inflammatory cytokines, which in turn may cause changes in the biochemistry of your brain, altering biochemical pathways and seriously affecting mood and behavior. Coenzymes typically are the enzymatic-forms of vitamins, such as pyridoxal 5-phosphate (the enzymatically correct form of vitamin B6), but sometimes coenzymes are biochemicals that few people have ever heard of. The concept here is simple: as a consumer, you are seeking to ensure that every bit of the tryptophan you consume produces and sustains serotonin, promotes health, and gives you the benefits you expect. The logical combining of the right nutrients for the right job then provides your cellular enzymes with the tools they need to perform their job.
My quest for a thorough understanding of tryptophan metabolism was inspired by the fact that people in the African nation, whom I spoke of earlier, and many others around the Earth are so poorly nourished they may fail to thrive from whatever food or rations they receive. Even in prosperous countries, unwise diets can block the enzymes that you need to utilize essential amino acids. In stark contrast to the designer chemicals coming out of laboratories, tryptophan occurs naturally in your diet, and a healthy body is born with the ability to process L-tryptophan without side effects. Dozens of research papers demonstrate that supplements of natural tryptophan increase serotonin levels in the brain and promote healthy receptors, something no designer chemical currently can do. Less well-known, though, is the fact that only a small percentage of tryptophan goes down your serotonin pathwaya€¦ nearly all the rest goes into building proteins throughout your body. Inside a serotonin-producing neuron, tryptophan works with a coenzyme, abbreviated BH4, to form the well-known 5-hydroxy tryptophan (5-HTP).
Well-funded researchers in university laboratories have found that BH4 actually increases the throughput of the serotonin pathway.


The second step to serotonin production requires vitamin B6, but here we should make a distinction. And while pure P5P costs far less than $4 million per kilogram, P5P still is twelve (12) times more expensive than the cheap chemical, pyridoxine HCl that often is found in supplements. As we see, the right combination of cofactors and coenzymes drives the conversion of tryptophan to serotonin. This is not the entire picture, of course, but in order to experience the benefits of tryptophan, two things need to be true. The second is that you need to carefully select a diet to maintain a healthy gastrointestinal environment. A point that rarely receives much notice is the cosmetic reworking of amino acids to make them appear a€?pure.a€? There are milling and whitening procedures that often are applied just to give amino acids a sparkling-white, bleached, a€?purea€? look. If a crystalline amino acid has never been a€?flatteneda€? to give a shiny appearance, you end up with a fluffier material that takes up more space in a capsule.
Because tryptophan is essential, no other amino acid, vitamin, mineral, herb or designer chemical can take its place, and tryptophan is routinely added to baby food and hospital IV solutions, where it is essential for growth and life. Furthermore, blood amino-acid profiles of hundreds of patients, along with the extensive analysis of foods done by Dr.
Whether you are worn out by the common stresses of this world, or whether you suffer from an amino-acid imbalance that seems to be depleting your serotonin, consider trying the essential amino acids - beginning with the one we lack most.
Disclaimer: This website is intended for educational purposes only and is not intended to replace the diagnosis or recommendations of a health-care professional. Included in this category are other substances like herbs and botanicals and amino acids, as well.Although dietary supplements are regulated by the FDA, they are regulated as food products and not actual drugs. Many of Hollywood’s A-List celebs take supplemental enzymes or use cosmetic products formulated with them to slow or reverse the signs of aging. Combining enzymes into a daily cosmetic regime can allow moisture and active ingredients to penetrate deeper and work more effectively.
When I know I am going to consume meals low in them, I pop 2-3 pills depending on how large the meal is. There are many directions that tryptophan, for example, can take, and each step along a pathway is like a toll-booth controlled by an enzyme. Enzymes are as useless as a car without wheels if they lack critical coenzymes and cofactors (vitamins, minerals, etc.) that allow an enzyme to function. The challenge is to encourage tryptophan to follow the one branch that leads to serotonin and to discourage tryptophan from converting into less-desirable chemicals such as kynurenine or quinolinic acid.
Susan Swedo, acting scientific director at the National Institute of Mental Health (NIMH), discovered that muscle tics and repetitive, compulsive behaviors could sometimes be traced back to childhood infections. Furthermore, your immune system can be activated by any number of factors, including infections, food allergens, or environmental toxins. Cytokines are proinflammatory proteins that help your body fight infections - up to a point. An unfortunate consequence of IDO is that it degrades tryptophan and shuttles the breakdown products into the making of kynurenine and quinolinic acid, thus diverting tryptophan away from the production of serotonin.


In further contrast to tryptophan, designer chemicals can lose their effectiveness over time by damaging your serotonin receptors. So, increasing that percentage even a small amount can provide a dramatic boost to your brain serotonin levels. Although it doesna€™t take much BH4, the astronomical cost of $4 million per kilogram (when purchased as a research biochemical) keeps BH4 far out of the reach of nutritional supplements. This added expense, though, helps to ensure your supplements work the way they were designed to work. Phosphorylation can convert limited amounts of the chemical-form of B6 to the natural form of vitamin B6.
In fact, very recent research shows that the widely used herbal extract, curcumin, a bright yellow extract from the turmeric root that is used in curry, helps to preserve serotonin and slow its breakdown. The first is that you need to consume a full spectrum of nutrients that can ensure the proper metabolism of tryptophan. Healthy intestinal bacteria can help to control an over-zealous immune response that can profoundly disrupt your metabolism and brain chemistry. Manufacturers know that consumers often judge by appearances, but what they do not know is that reworking a nutrient to improve the appearance can actually degrade the quality of a nutrient. In turn, this makes the encapsulation process slower and more labor-intensive and more expensive. Charles Jarowski, former Director of Research and Development at Pfizer, Inc., demonstrate that tryptophan is the essential amino acid most lacking in our diet. Dietary supplements do not have to be pre-approved before they enter the market, but manufacturers are held to very strict guidelines on what they can contain and what types of claims they can make.
Most of my friends swear by the weight loss potential of supplementing with digestive enzymes.
When she filtered her patientsa€™ blood, removing antibodies originally created to combat the infection, she found that the compulsive behaviors cleared.
A combination of precursors can provide the building-blocks for BH4 at a far more affordable price. Serotonin-producing enzymes can only use the natural, enzymatic form of vitamin B6, pyridoxal 5-phosphate (P5P). Knowledgeable researchers have voiced concern, however, that pyridoxine HCl may actually block vitamin-B6 receptors, possibly leading to vitamin B6 deficiency symptomsa€¦ the opposite of what you would expect from a a€?vitamin B6a€? supplement! In the end, though, by taking extra time, we have not introduced contaminants into a product simply for a a€?cosmetica€? effect. Because a simple boost in serotonin may provide you with restful sleep and brighter, happier moods.
A collection of Infographics and data visualisations on various topics in the Pharmaceutical and Healthcare industry.



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