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My medzilla: find thousands outstanding job, Medzilla, the original and best place to find your next job or career in pharmaceuticals, , biotechnology jobs, clinical research associate. Copyright © 2012 Rachael Edwards, All trademarks are the property of the respective trademark owners. If you haven’t heard yet that Santa Cruz is fast becoming a biotech hub, it’s time to start paying attention. I asked each to share some challenges and successes and say why they think Santa Cruz is a great place to locate a biotech company. The company was founded by three UCSC graduate students: Steve Benz, Charles Vaske, and Zack Sanborn. One of the greatest challenges we face is trying to help change the way oncologists treat their patients. Isentio founders selected Santa Cruz as home base because it’s close enough to the South San Francisco biotech hub, as well as to Silicon Valley, and also offers quality of life and a family friendly community.
They value the proximity to UC Santa Cruz because the university provides an influx of scientists with diverse backgrounds and collaboration opportunities.
As a veteran of biotech startups over-the-hill, I look forward to the opportunity to build a team of world-class PhD and Masters-level scientists here in Santa Cruz.
Santa Cruz is chock-full of bright and creative people with experience in a wide variety of fields, and potential collaborators, customers, and mentors are out there with a little investment in networking.
Speaker said that since Capsulent started with a technology platform that lacked a definite application, the biggest challenge was to find the right market and segment in which their delivery system could really shine.
In its pursuit to help advance the understanding and the treatment of human diseases, the company focuses on RNA molecules as therapeutic targets and biomarkers. Johnston reports the biggest challenge has been landing large development deals with big pharma companies when their interests and company strategy change every few years. Maverix Genomics, founded by UC Santa Cruz professor Todd Lowe and featured recently by Santa Cruz Tech Beat, could have been on the list but, alas, they’re located in San Mateo.
It’s no secret that local biotech companies value the proximity to cutting edge research just up the hill at UC Santa Cruz.
If any of you STEALTH local biotech companies decide to un-stealth, please contact me, I would be happy to add your company to the list. Sara Isenberg curates and publishes Santa Cruz Tech Beat for the benefit of the extended business and technology community.
This feature profiles six companies but the truth is there are more than six biotech companies that call Santa Cruz home. Five3 Genomics is a cancer genomics company specializing in analysis of individual patient tumor genomes for precision treatment guidance. Being located in Santa Cruz allows them to keep close ties with the cutting-edge genomics work being done at UC Santa Cruz.


Instead of prescribing treatments based on broad categories to which a patient’s cancer belongs, we have an opportunity to utilize the genetic characteristics unique to their cancer to better inform the oncologist on what treatments may or may not succeed.
Isentio saves lives, suffering and healthcare cost through 90% faster and more accurate bacteria identification. We know we have a great working product that customers love, and that we really can change today’s diagnostics workflow and save significant healthcare cost, but we need capital to scale and get the word out. Galen Biotechnologies is an early-stage drug development company focused on the discovery of novel treatments for cancer, inflammation, and other human diseases.
We aim to revolutionize drug discovery using our proprietary technologies to address multiple unmet medical needs. Capsulent supplies charged-film microcapsules to over-the-counter pharmaceutical companies and personal care markets as a B2B raw material supplier.
Additionally, Santa Cruz is culturally very innovation-supportive, the opposite of a company-town mentality, so entrepreneurially minded folks don’t have to feel isolated or lacking in community. The unexpected breakthrough in hair products has been a major success with strong domestic and international growth. SomaGenics develops innovative therapeutics and diagnostics that address unmet medical needs. We have demonstrated efficacy of a new hepatitis C treatment in preclinical studies and established proof of concept for a new class of RNA-interference-based therapeutic agents. Santa Cruz remains attractive to SomaGenics in part because UC Santa Cruz has a strong biology and bioinformatics program, and it’s easy for them to recruit qualified graduates and post-docs from that program.
SomaGenics’ biggest success was developing the first RNA-interference-based drug candidate shown to be effective against a hepatitis C virus infection. Roger Kaspar, TransDerm CEO, considers the beauty of the area, the people, and the proximity to cutting edge science is what make Santa Cruz a great place to live and work.
For more about Biotech and Genomics at UCSC, visit the Center for Biomolecular Science and Engineering’s website. When she is not volunteering her time for the tech scene, Sara makes her living by managing software projects, web strategy planning, and providing development team services (including account management, vendor management, strategic partner management, beta project management, referrals to qualified technical team members, and more). They also work with pharmaceutical companies to identify new potential drug targets and patient groups that currently have no viable treatment options. The university has been a source of talented employees, with most of their employees having or currently obtaining degrees from UCSC. That leads to some of our greatest success stories where our tools have identified treatment options that obtained responses in patients who had no other options.
RipSeq™ software as a service can identify the bacteria causing an infectious disease within the same day instead of 3-7 days with today’s primary method. Everybody know there will be a shift in the diagnostic market from traditional identification methods soon and that DNA technology will be the golden standard – the question is when and how.


Their vision is to create vast drug-candidate libraries with such high diversity that the normal time frame for drug discovery can be dramatically shortened. Our biggest challenge has been securing proof-of-concept funding in order to commercialize our technologies. We have also developed novel diagnostic tools to quantify micro-RNAs as biomarkers of disease and guides to treatment. Add to that, the quality of life that all of the companies featured in this article clearly appreciate, and the resources of the SF Bay Area within a reasonable driving time. TransDerm is fortunate to have talented and dedicated employees, a partnership with a highly effective patient advocacy group, the financial support of the National Institutes of Health and terrific collaborations with leading physicians and scientists throughout the world. The Santa Cruz Chamber of Commerce  honored Five3 Genomics as Entrepreneurs of the Year in 2012. Above all our goal is to help cancer patients obtain the best possible care available, which is something we are all very passionate about. This ensures the patient correct treatment the first time, reducing the use of broad specter antibiotics, decreasing side effects, and shortening the hospital stay. Our rapid progress in the UC Santa Cruz campus Bioincubator has been invaluable in this respect. Capsulent’s controlled-release microcapsule technology uses nature-derived materials to wrap active ingredients in a membrane-like structure just microns across. They work in partnership with the non-profit patient advocacy group PC Project and the International PC Consortium (IPCC, a group of scientists and physicians that has agreed to work together to develop therapies to relieve suffering of those afflicted with PC). We hope we are able to be a part of the growing presence of biotech in the Santa Cruz area. Their lead candidate is currently in clinical trials at Stanford University and a second will enter clinical trials later this year. Optofluidics is defined as the combination of microfluidics or nanofluidics and optical methods. TransDerm also has expertise in other areas including intravital skin imaging (visualizing non-invasively what happens within the skin replacing the need for skin biopsies), preparing human skin equivalents (similar to what is used to treat burn patients) to use to test the effectiveness of drugs and evaluating the ability of formulated drugs to penetrate the skin barrier and functionally alter gene expression in various skin model systems. Measor is a UC Santa Cruz Ph.D graduate, and Schmidt and Deamer are UC Santa Cruz professors at the Baskin School of Engineer. Had I been in contact with Liquilume before publication, the title of this feature article may have been Seven Companies to Watch in the Emerging Santa Cruz Biotech Hub.



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