Think of the endothelium as the satin lining of a coat sleeve, if it gets snagged or ripped, your arm will not go through it smoothly, Similarly -blood doesn’t flow smoothly in adamaged artery, and it can actually do more damage. We are currently in the process of adding new questions every day - so please bookmark us for future reference.
A heart attack is a result of a blocked artery which is responsible to provided blood to the heart.
Researcher Richard Rainbow said, a€?We have shown that the amount of sugar, or glucose, in the blood changes the behavior of blood vessels, making them contract more than normal. Obesity may be curbed by gradually reducing sugar content in beverages Sucralose (Splenda): Good or Bad? It has been known for quite some time that people with diabetes have slower metabolisms which are clearly shown by fat deposits on the heart and the muscles surrounding it. This opens the doors to new research, as from these early results it seems that high blood sugar and insulin levels may be one of the biggest causes of heart disease.
The best natural way to control diabetes and prevent fatty deposits in the heart is by managing your blood sugar levels with the 100% organic Manna Blood Sugar Support caplets, 2 with each meal.
By following a low GI diet or by following the Diabetic Diet in the FREE Manna Diabetes e-book will also help to control blood sugar levels and manage insulin in the body. Assays created in a Rice University lab contain interstitial heart-valve cells, collagen and nutrients.
A Rice lab, in collaboration with the University of Texas Health Science Center at Houston (UTHealth) Medical School, discovered that the interstitial cells that turn raw materials into heart valves need just the right amount of nutrients for proper metabolic function. Diabetes is a metabolic disease characterized by high blood-sugar levels over a long period; a 2006 study of atherosclerosis by University of Washington researchers found a correlation between diabetes and aortic-valve calcification. In the new work by the lab of Jane Grande-Allen of Rice's bioengineering department, recentlyA ranked No. Rice University alumnus Peter Kamel, left, and bioengineer Jane Grande-Allen have found a possible link between diabetes and the hardening of heart valves. Grande-Allen's lab studies the biomechanics of heart valves, particularly their calcification, or hardening, a condition that lessens blood flow to the heart. The idea for the study came about when she met with Heinrich Taegtmeyer, a cardiologist and professor at UTHealth.
Kamel started with solutions of collagen, the most abundant protein in the body, and cells drawn from the aortic heart valves of pigs. When the cells worked at peak, Grande-Allen said, they would contract the liquid into a gel as they absorbed and metabolized nutrients, and then turned raw collagen into connective tissue. The researchers found solutions with 2 grams of glucose per liter were optimal for contraction. To understand any heart valve-related disease, "we need to understand the mechanism of how the cells interact with excess lipids and sugars, and we're just starting to scratch the surface," she said.
Heart valves calcify over time, and Rice University scientists are beginning to understand why.
A study comparing how blood stem cells and leukemia cells consume nutrients found that cancer cells are far less tolerant to shifts in their energy supply than their normal counterparts. Researchers have found a way to take a pediatric patient's skin cells, reprogram the skin cells to function as heart valvular cells, and then use the cells as part of a tissue-engineered pulmonary valve. While calcium's importance for our bones and teeth is well known, its role in neuronsa€”in particular, its effects on processes such as learning and memorya€”has been less well defined. A novel MRI method that detects low levels of zinc ion can help distinguish healthy prostate tissue from cancer, UT Southwestern Medical Center radiologists have determined.
Salk Institute scientists have discovered the holy grail of endless youthfulnessa€”at least when it comes to one type of human kidney precursor cell.
A ground-breaking Auckland study could lead to discoveries about many common diseases such as diabetes, cancer and dementia.
Blood Sugar 101 does not control which products appear in Google Ads or endorse these products. The endothelium becomes stickier, attracting blood clots, thus causing the blood vessels to constrict and not expand smoothly – which eventualy can lead to high blood pressure. High blood sugar has been found to lead to stronger contractions of blood vessels along with researchers identified a protein responsible for these contractions.
High blood sugar can worsen this blockage by causing the artery to contract which increases the risk of complications.

This could result in higher blood pressure, or could reduce the amount of blood that flows through vital organs. Insulin is made by the islet cells located in the pancreas, and is responsible for regulating the blood sugar levels.
Up until now, researchers could not find out why exactly this happens, but recent research has revealed that it is caused by the combination of high blood sugar levels and high levels of insulin. The action of this product in the body not only helps to control blood sugar levels but also helps the body to require less insulin. These contain varying levels of glucose metabolized by the cells as they create the extracellular matrix that forms valves.
He is in his third year at Baylor College of Medicine, where he is completing a dual-degree program offered by the neighboring Houston institutions. In the new study the researchers took on the little-understood process of interstitial valve-cell metabolism. Kamel's experiments combined Taegtmeyer's ideas about cell metabolism and the Grande-Allen lab's capabilities to explore ways to manipulate interstitial cells. Most solutions also included a nutrienta€”glucose, pyruvate, glutamine or a supplement mixture called F-12a€”to stimulate the cells' metabolism.
Because off-the-shelf solutions come in standard concentrations of 1 and 4.5 grams per liter, researchers who don't mix their own solutions could easily miss the connection between glucose level and metabolism, Kamel said.
The new finding could also illuminate the broader role of the enigmatic mitochondria in human development. It is mostly prevalent in young children and teens, who must take multiple insulin injections daily to replace the insulin the body is not making.when glucose levels rise (hyperglycemia) the pancreas responds by releasing the hormone insulin to convert the excess glucose into energy for the cells to use as fuel. The lab found that 2 grams per liter of glucose in the solution (center vertical row) worked best, but either more or less slowed the process. News & World Report, researchers have directly seen the effect of high blood-sugar levels on heart-valve cell metabolism for the first time.
Rice chemical engineer Deepak Nagrath also contributed key insights about how to examine the metabolism of these cells. A study conducted in Italy, which analyzed 14 years of blood sugar data taken from people recently diagnosed with Type 2 diabetes, concluded "A1C and blood glucose 2 h after lunch but not FBG [fasting blood glucose] predict cardiovascular events and all-cause mortality." The reason only sugars after lunch were cited here is that the study did not analyze post-dinner readings, only pre-dinner readings.
In Type 1 diabetes there is no insulin production, thus depriving the cells of the fuel they need for proper functioning. If blood sugar levels are not brought under control, complications can occur and cause damage to the major organs of the body. Postprandial Blood Glucose Predicts Cardiovascular Events and All-Cause Mortality in Type 2 Diabetes in a 14-Year Follow-Up Lessons from the San Luigi Gonzaga Diabetes StudyFranco Cavalot et al. They found dangerously high rises in 95% of people with diabetes in their study, probably because they were encouraged to eat the extremely high carbohydrate, ADA-recommended diet and attempt to counter the resulting post-meal high blood sugars with oral drugs--which the study found, did not control the peaks.
Postmeal glucose peaks at home associate with carotid intima-media thickness in type 2 diabetes Katherine Esposito, et. This is due to damage of the vagus nerve, which is responsible for moving food through the digestive tract.Persons who have been diagnosed with diabetes require specialized care to to stay in the most optimal health.
It is important to monitor daily blood glucose levels to keep them within normal limits to prevent the many complications that can occur. For example, a study published in November of 2009 linked blood sugar readings one hour after ingesting glucose with high fibrinogen and leukocytes count (WBC), which point to subclinical inflammation, and with abnormal lipid ratios, and insulin sensitivity in a population of 1062 participants with normal glucose tolerance or prediabetes. There is extra work involved as diabetics must do for their bodies what their bodies can't do. This study found Elevated 1hPG [one hour plasma glucose] in NGT [people with normal glucose tolerance] and pre-DM subjects is associated to subclinical inflammation, high lipid ratios and insulin resistance. When the body ceases to make insulin, or the insulin being produced is not being used effectively, one must take over that job by closely monitoring their glucose levels and administering to the body the insulin that is lacking. The reliance of doctors on two hour glucose tolerance test results allows people to live for years with blood sugars high enough to promote complications long before they are diagnosed even pre-diabetes.Inflammation markers and metabolic characteristics of subjects with one-hour plasma glucose levels. Be mindful of your salt intake as too much sodium in the diet can raise the blood pressure. Consistently high blood pressure causes damage to the major organs of the body leading to added complications of diabetes.Make regular visits with your health care provider to catch any potential problems in their early stages when they are most easily treated.
Now an intriguing study has found a strong correlation between post-challenge blood sugar (i.e.

Herrington Diabetic Medicine 24 (10), 1156-1159.If you do have diabetes, what does this mean for you? It means that the best thing you can do to avoid getting heart disease or to slow its development if you are in the early stages is to prevent your post-meal blood sugars from rising over normal limits. Also, this finding should encourage you to limit the carbs everyone in your family eats, because it's almost certain some of the supposedly "normal" people around you are getting the high post-meal high blood sugars that produce heart disease though they are not getting diagnosed thanks to their normal fasting blood sugars. The fasting blood sugar test is the only test most American doctors use to evaluate blood sugar health.A1c Accurately Predicts Heart Attack RiskThis was discovered in the large-scale epidemiological study called EPIC-Norfolk. What's particularly valuable about this study is that the researchers weren't originally looking for causes of heart disease.
They were studying cancer and they were looking at A1c because of the belief that it might be related to cancer incidence, which turned out not to be the case. The finding that A1c predicted heart disease in people with supposedly normal blood sugar was a shocker. Association of Hemoglobin A1c with Cardiovascular Disease and Mortality in Adults: The European Prospective Investigation into Cancer in Norfolk. Persons with hemoglobin A1c concentrations less than 5% had the lowest rates of cardiovascular disease and mortality. A study presented by Dr Esther van 't Riet at the EASD meeting in Sept, 2007, confirmed that even for people without diabetes A1c closely matches heart attack risk. It found that though A1c matched cardiac risk, 2 hour oral glucose tolerance test (OGTT) results did not. It found no association between fasting blood sugar and risk of heart disease, but A1c was a different story. The table below summarizes the correlation of baseline A1c with the risk of developing cardiovascular disease.
March 4, 2010 Number 9.Keep in mind that because these subjects were probably diagnosed as "non-diabetic" using a fasting glucose test many of those with the higher A1cs probably were diabetic at the study outset based on post-meal values. Since the relationship between blood sugar level and cardiac risk is so clear cut it looks like people with diabetes don't get heart attacks because diabetes does something special to the heart.
You may have to fight with your doctor to get a prescription, but insulin, prescribed properly, is a lot safer than any of the newer, very expensive, overhyped diabetes drugs most doctors prescribe first. You can read about the problems with all these drugs by following links you'll find on our Drugs Page NOTE: When Your A1c May Be InaccurateDoctors have a touching faith that the A1c reflects your blood sugar control.
When you are anemic the A1c will be much lower than the value corresponding to the actual concentrations of glucose in your bloodstreamIf you are on dialysis. If you are on dialysis your A1c will also be much lower than the value that reflects your actual blood sugars.If you have certain genetic variants of the red blood cell.
Test your blood sugar with a meter after meals frequently enough that you get a good idea of what your blood sugars are doing.
If you test after meals and consistently see high blood sugars, trust your meter readings over a low A1c If this happens to you, the fructosamine test may give you a more valid measurement of long term control. Because there is a growing amount of evidence that it is blood sugars spikes after eating that damage your organs not only the glycation of proteins reflected in the A1c, it is dangerous to think a low A1c means you have nothing to worry about if your post-meal blood sugars are going into the damage zone.
But what about Cholesterol?With so much evidence pointing to the predictive value of post-meal blood sugar and A1c why do most doctors continue to focus on cholesterol test values and prescribe statins rather than urge you to lower your post meal blood sugars (which will lower your A1c)?Drug companies have sold doctors and the public on the idea that they can prevent heart attacks by lowering LDL--even though this is far from what the data actually prove. This is probably because the true effect of statins is to lower vascular inflammation, not LDL.
Why Cholesterol and LDL Poorly Predict Heart Attack RiskYou would never know it from the statin ads, but half of all people who have heart attacks have no known risk factors--which means, among other things, that they have completely normal cholesterol.
Fifty percent of patients with coronary artery disease do not have any of the conventional risk factors. The more carbs you eat, especially those that circulate in your blood stream as high blood sugar, the higher your triglycerides will be. Triglycerides in Heart Muscle may Be At Fault A study published in the September 4, 2007 issue of Circulation comes up with a novel observation that may explain why high post-meal blood sugars are associated with heart attacks in people with diabetes.
The study found that "lipid overstorage in human cardiac myocytes is an early manifestation in the pathogenesis of type 2 diabetes mellitus." This means that lipds are overstored in heart muscle very early in the progress of diabetes.

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