Glucose tolerance tests help to diagnose type 2 diabetes or impaired glucose tolerance - a condition that may lead to diabetes.
THE MEDICAL PROFESSION WOULD have you believe that diabetes is not reversible and only controlling your blood sugar with drugs or insulin will protect you from organ damage and death.
The diabetes epidemic is accelerating along with the obesity epidemic, and what you are not hearing about is another way to treat it.
Type 2 diabetes, or what was once called adult onset diabetes, is increasing worldwide and now affects nearly 100 million people — and over 20 million Americans.
We are seeing increasing rates of Type 2 diabetes, especially in children, which has increased over 1,000 percent in the last decade and was unknown before this generation. In a report in The New England Journal of Medicine, Walter Willett, MD, PhD, and his colleagues from the Harvard School of Public Health demonstrated that 91 percent of all Type 2 diabetes cases could be prevented through improvements lifestyle and diet. Here, I want to review in detail this new way of thinking about diabetes and outline the tests I recommend to identify problems with blood sugar. When your diet is full of empty calories, an abundance of quickly absorbed sugars and carbohydrates (bread, pasta, rice, potatoes, etc.), the body slowly becomes resistant to the effects of insulin and needs more to do the same job of keeping your blood sugar even.
Insulin resistance and the metabolic syndrome associated with it is often accompanied by increasing central obesity, fatigue after meals, sugar cravings, high triglycerides, low HDL, high blood pressure, problems with blood clotting, as well as increased inflammation. These clues can often be picked up decades before anyone ever gets diabetes — and may help you prevent diabetes entirely. If you have a family history of obesity (especially around the belly), diabetes, early heart disease, or even dementia you are even more prone to this problem.
Most people know about the common complications of diabetes such as heart attacks, strokes, amputations, blindness, kidney failure, and nerve damage.
Diabetes and pre-diabetes ARE reversible by aggressively changing lifestyle, nutritional support, and occasionally medications. In fact many people with pre-diabetes never get diabetes, but they are at severe risk just the same. We were highly adapted to a nutrient-dense, low-sugar, high-fiber diet rich in omega-3 fats. Now, in just one generation, they are nearly all obese and 80 percent have diabetes by the time they are 30 years old! New science shows that it’s possible, through an aggressive approach of lifestyle, nutritional support, and occasionally medications. It is important to diagnose Type 2 diabetes early, but it is often not diagnosed until very late. In fact, all doctors should aggressively diagnose pre-diabetes decades before diabetes occurs, and before any damage is done to your body.


Unfortunately, there is a continuum of risk from slightly abnormal insulin and blood sugar to full blown diabetes. In a recent study, anyone with a fasting blood sugar of over 87 was at increased risk of diabetes. Most doctors are not concerned until the blood sugar is over 110 — or worse, over 126, which is diabetes. Insulin Glucose Challenge Test – This should be done with a 2-hour glucose challenge, 75 grams measuring fasting, 1- and 2-hour blood sugar AND insulin. Hemoglobin A1C Test – This is an important measure of glycated hemoglobin, which can be an early indicator of sugar problems. NMR Lipid Profile – This test is slightly different from the one above as it identifies the size of your cholesterol particles.
High Sensitivity C-Reactive Protein Test – This is a measure of inflammation, one of the classic conditions that is both the cause and result of insulin resistance and diabetes.
Fibrinogen Test – This measures your risk of clotting, which can cause heart attacks and strokes.
Please leave your thoughts by adding a comment below – but remember, we can’t offer personal medical advice online, so be sure to limit your comments to those about taking back our health!
Mark Hyman MD is the Medical Director at Cleveland Clinic’s Center for Functional Medicine, the Founder of The UltraWellness Center, and a ten-time #1 New York Times Bestselling author.
So, the C-Peptides follow roughly the same arc, and ratio of rise, as the insulin levels.  So, now I know. Series NavigationMy 2010 Glucose Tolerance Test – Have I Goofed?July 2012 Glucose Tolerance Test – Passed! Type 2 diabetes mellitus is characterized differently and is due to insulin resistance or reduced insulin sensitivity, combined with relatively reduced insulin secretion which in some cases becomes absolute. When glucose levels become depleted, glucagon and cortisol levels rise significantly to enhance gluconeogenesis. Up-regulation (receptors) occurs with insulin after 4 weeks of exercise to increase its sensitivity (diabetic importance).
This material is based upon work supported by the Nursing, Allied Health and Other Health-related Educational Grant Program, a grant program funded with proceeds of the State’s Tobacco Lawsuit Settlement and administered by the Texas Higher Education Coordinating Board.
But medication and insulin can actually increase your risk of getting a heart attack or dying. Insulin resistance, when the body becomes resistant to the effects of insulin, is primarily what causes diabetes. The high insulin leads to an appetite that is out of control, and increasing weight gain around the belly.


Some may even know that it increases your risk of dementia and cancers and can cause impotence. Therefore, I recommend early testing with anyone who has a family history of Type 2 diabetes, central abdominal weight gain or abnormal cholesterol.
Your blood sugar should be less than 80 fasting and never rise above 110 or 120 after one to two hours.
It measures sugars and proteins combining into glycated proteins called AGEs (advanced glycation end products), like the crust on bread, or the crispy top on creme brule.
An HDL or good cholesterol level under 60 and triglycerides over 100 should make you suspicious of insulin resistance. With insulin resistance or Type 2 diabetes, you develop small LDL and HDL cholesterol particles. I have seen this hundreds of times in my patients and there is no reason you can’t achieve the same thing if you apply these principles.
Your insulin should be less than 5 fasting and should never rise above 30 after one to two hours. These create inflammation and oxidative stress throughout the body, and promote heart disease and dementia and accelerating aging. They are much more dangerous than larger particles and lead to increased risk of atherosclerosis or heart disease. In fact, anyone with a high C-reactive protein has a 1,700 percent increased risk of getting diabetes.
This is entirely due to sugar and carbohydrates in our diet that cause fatty liver, liver damage, and even cirrhosis.
I recommend this test for everyone over 50, and for anyone with any risk of insulin resistance, even children.
Hormones are chemicals that are released into the bloodstream and work on various parts of the body. A glucose tolerance test helps to distinguish between this normal pattern and the patterns seen in diabetes and impaired glucose tolerance.



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