This report presents how testing for diabetes has changed since the recommendations were published. HbA1c should be the test of choice for testing for and diagnosis of type 2 diabetes in most people. I know you're gonna suggest me regular exercise and a diet with more salt, but I'm already quite active and I eat more salty food that I ate before. Both ephedrine and pseudoephedrine increase blood pressure and act as bronchodilators, with pseudoephedrine having considerably less effect.
Location The vagabond who's rapping at your door, standing in the clothes that you once wore. I think i mentioned phenylephrine which was in my flu drink i took the other day and every day since. As Knock said its probably best to see a doctor rather than self medicate blood pressure issues.
We evaluated the antihyperglycaemic properties of aqueous-methanolic (40:60) extract of root of Musa paradisiaca and leaf of Coccinia indica in separate as well as in composite manner by conducting experiment on streptozotocin-induced diabetic rats.
Diabetes is recognized as one of the leading causes of mortality and morbidity in the world (Can et al., 2004). Coccinia indica is a climbing perennial herb of Cucurbitaceae family and it is distributed widely all over India. Forty rats were divided into five groups equally as follows and duration of experiment was of 14 days.
Fasting blood glucose (FBG) level was measured from the first day of extract supplementation to diabetic rats. After overnight fasting, on the day the animals were sacrificed, a zero-min blood sample was taken from tip of tail vein of all the rats: control (Group I), diabetic (Group II), diabetic + M. The liver glucose-6-phosphatase activity was measured according to standard protocol (Swanson, 1955). The liver glucose-6-phosphate dehydrogenase activity was measured spectrophotometrically (Langdon, 1966). The enzyme activity was determined on the basis of reduction of NADPH coupled with hexokinase which was measured spectrophotometrically at 340 nm (Chou and Wilson, 1975). Glycogen levels in liver and skeletal muscle were measured biochemically (Sadasivam and Manickam, 1996). Liver and kidney GOT and GPT activities were measured using the kit supplied by Crest Biosystems, Alto Santacruz, Bambolim Complex (Goa, India). Body weight, water and food intake of diabetic animals decreased significantly and after composite extract supplementation there was a significant recovery of these parameters towards the control level although separate or individual extract of the M. Streptozotocin injection resulted in a significant elevation in fasting blood glucose level throughout the experiment compared to control and the diabetic-induced animals were unable to tolerate extra glucose load.
Streptozotocin-induced diabetic animal resulted in a significant elevation in glucose-6-phosphatase activity along with diminution in glucose-6-phosphate dehydrogenase and hexokinase activities in liver with respect to control group. Streptozotocin induced diabetes resulted in an elevation of GOT and GPT activities in liver and kidney at significant level when compared to control. DiscussionStreptozotocin-induced experimental diabetes is a valuable model for induction of type-I diabetes (Junod et al.,1969). Aqueous-methanolic extract of these plants resulted in a significant recovery of these enzymes which may be one of the ways of antidiabetic efficacy of these plants.
Protective effect of diabetes of the extract of above plants has been supported with the results obtained with regards to food intake and water intake tending towards the control level in diabetic animal after the extract co-administration. From the comparative analysis, it has been revealed that the extract of the studied plants when used in composite manner on streptozotocin-induced diabetic state has a more potent antidiabetogenic effect in comparison to the antidiabetogenic activities of the individual extract of the plants.
AcknowledgementThis research work was funded by University Grants Commission, New Delhi, India.
Patients with diagnosed diabetes were excluded from the analysis using a virtual diabetes registry algorithm that included diabetes medicines, laboratory tests and hospital discharges for diabetes-related diagnosis codes.


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They were having nasty side effects so they reduced their dose without speaking to their doctor. Get a head rush most days from just standing up to fast (and shallow breathing beforehand.) Sounds like its bothersome to you though.
From wiki Phenylephrine is a selective α1-adrenergic receptor agonist used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure. My doctor advised my to measure my BP regularly and so I did (apparently there isn't much we can do about my low blood pressure). We measured food and water intake ability, the fasting blood glucose level, glucose tolerance, activities of important carbohydrate metabolic enzymes like glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, hexokinase in liver along with quantification of glycogen in liver and in skeletal muscle and serum insulin level. It is a heterogeneous group of diseases and at present it is known as syndrome (Zimmet, 1997).
Animals were acclimated for a period of 15 days in our laboratory condition prior to the experiment. One unit of enzyme activity is defined as that quantity which catalyses the reduction of 1 µM of NADP per minute. Tissue homogenized in 80% ethanol, and extract was collected by centrifugation using anthrone reagent, and quantity of glycogen was measured in relation to standards, which was expressed in µg of glucose per mg of tissue. The activities of these enzymes were expressed as unit per gram of tissue (Henry et al., 1960). Treatment of composite extract to streptozotocin diabetic animals resulted in a complete recovery of fasting blood glucose level on 16th day of treatment and the animals were able to tolerate the exogenous glucose load and behaved as control. The present investigation highlights the antidiabetic efficacy of aqueous-methanol extract of M.
Elevation in the activity of glucose-6-phosphatase in STZ-induced diabetic group as reported in the previous studies (Pari and Amarnath, 2004). Diabetic condition resulted in liver and renal toxicity induction, which has been observed in this study as shown by GOT and GPT assessment and as reported by others (Ghosh and Suryawanshi, 2001).
In conclusion, it may be stated that this composite extract contains the active antihyperglycemic agent (s) that can be used to overcome diabetic complication by pancreatic β cell regeneration or stimulation of insulin secretion or in other ways. This algorithm identified 186,560 registered patients with diabetes (4.4% of all registered patients). The result was a spike in blood pressure which burst a blood vessel in their eye, making their already poor vision even worse. Phenylephrine is marketed as a substitute for the decongestant pseudoephedrine, though clinical studies differ regarding phenylephrine's effectiveness in this role. The central identifying feature of diabetes mellitus is chronic and substantial elevation in the circulating glucose concentration.
Root and leaves of this plant have antilipidemic effects (Eshrat, 2003) as well as antioxidative effects (Venkateswaran and Pari, 2003). Insulin enzyme linked immunosorbant assay (ELISA) kit was purchased from Boehringer Mannheim Diagnostic, Mannheim (Germany).
Activity of this enzyme was recorded by using glucose-6-phosphate as a substrate and absorbance was measured at 340 nm. Individual extract treatment in separate manner to diabetic animal was unable to reverse these parameters to the control level but was able to protect the above parameters partially (Tables 2 and 3). Extract of these plants resulted in a significant recovery in the activity of this enzyme in liver and this may suggest another possible way of its antidiabetogenic efficacy.
Both separate and composite extract treatment in diabetic animal resulted in a significant recovery in the levels of GOT and GPT activities in liver and in kidney with respect to diabetic group. Are there any drugs that can be bought without prescription and will help me elevate my blood pressure?
Serum insulin level that was diminished in streptozotocin-induced diabetic rat recovered significantly after the co-administration of extract of above plant parts.


The major mode of control of diabetes can be achieved by diet, exercise, insulin replacement therapy and by the use of herbal hypoglycemic agents (Ivorra and Paya, 1989).
This plant belong to the Musaceae family and is distributed throughout the India and Malaysia. The voucher specimens with HPCH No: 7, 8 of the plants were deposited in the Department of Botany, Vidyasagar University, Midnapore. Out of this powder, 100 g was suspended in 500 ml of aqueous-methanol (2:3) mixture and kept in incubator at 37 oC for 36 h. The reaction was stopped with 1 ml of 10% trichloroacetic acid (TCA) followed by chilling in ice and centrifuged at 3000 × g for 10 min.
Quantity of glycogen in liver and muscle decreased significantly in diabetic group compared with control group. I haven't had any noticeable problems so far, but lately I think the situation is getting worse. All the above parameters showed a more potent remedial effect after composite extract treatment with respect to separate treatment and none of the extract has any general metabolic toxicity induction.
Diet therapy along with insulin or oral hypoglycemic agent forms an important way of treatment in diabetes (Clark and Lee, 1995) though it has several demerits. The principles of laboratory animal care (NIH 1985) and instruction given by our institutional ethical committee were followed through out the experimental period. Co-administration of extract in group III, IV and V was performed early in the morning and at fasting state. Antihyperglycemic potency of these plant parts has been evaluated here by the measurement of body growth, water and fluid intake, fasting blood glucose level, intravenous glucose tolerance, activities of glucose-6-phosphatase, glucose-6- phosphate dehydrogenase, hexokinase in liver, and quantification of liver and muscle glycogen along with serum insulin level.
The mixture was then filtered and filtrate was dried by low pressure and residue was collected. The present study is important in this respect as this is the first biochemical study on the effects of the extracts of these two plants in the management of type-I diabetes mellitus. Separate and composite extract treatment of the above plants resulted in a significant recovery with respect to this effect and this may be due to either stimulation in insulin release from β cells noted in this study or due to insulinomimetic activity of some of the components present in this extract or due to combination of both effects. Similarly, the oral hypoglycemic drugs have many side effects such as nausea and vomiting, cholestatic jaundice, agranulocytosis, aplastic and hemolytic anemias, generalized hypersensitivity reactions, dermatological reaction and lactic acidosis (Khan and Shechter, 1991). When required the residue was suspended in olive oil in a fixed dose and used for treatment.
Regarding the mode of action of the extract of these plants, the exact mechanism can not be deduced from this experiment but the following hypothesis may be proposed. Plants have been used for the major source of treatment of diabetes mellitus from ancient time in the Indian medicine and in the world.
Glucose-6-phosphate dehydrogenase utilize glucose through pentose phosphate pathway and its activity is under insulin (Tian et al., 1998). Herbal drugs are mostly out of toxic or side effect than the chemical drug (Rao et al., 2003). It aids in combating diarrhea and dysentery and promotes healing of intestinal lesions in ulcerative colitis (Joshi, 2000). Induction of diabetes by STZ resulted in significant diminution in the activity of this enzyme in the liver and this is consistent with our previous report (Mallick et al., 2006).
From Indian medicinal system it is found that composite extract is most effective than the separate one.
On that background this work has been designed to find out the most effective extract of Musa paradisiaca and Coccinia indica in separate and in composite manner to correct the streptozotocin-induced diabetic disorders.



Normal blood sugar levels in fasting
Diabetic blood sugar level 500


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