I was both confounded and surprised because my diet is pretty darn excellent, particularly concerning those pesky, debilitating high glycemic carbs that proliferate the Great American Diet.
If you haven’t read My Blood Sugar Numbers Confound Me, you may wish to do so before continuing so that you can have context for the rest of this post.
The first thing that occurred to me when I got my blood test results was that both my father and uncle (his brother) developed adult-onset diabetes, which is called “Type 2 Diabetes”. I always thought that they both contracted that disease in their 60s because they ate crap, were overweight and didn’t exercise, but now I’m wondering if they had a genetic predisposition to type 2 diabetes and therefore would have gotten it even if they ate and exercised…ahh… well… like me? As the video in “My Blood Sugar Numbers” describes, I borrowed my sister’s glucometer and began testing my blood. In addition to the favorable post meal blood glucose numbers, I have another blood measurement marker that’s in my favor. Hemoglobin A1(c) is expressed in percentage terms because it’s measuring the percentage of hemoglobin that’s bonded to sugar. In subsequent posts, I’ll report about some other unhappy blood result I got in my last Life Extension test, such has high VLDL, Pattern B LDL Density Pattern, high inflammation markers and low thyroid indications.
You're gonna get (1) the Newsletter, (2) the four-part guide, Transform Your Body and Mind, and (3) the 12 Ageproof Biohacks. If you experience symptoms such as severe or increased thirst, frequent urination, unexplained weight loss or weigh gain, increased hunger, a  tingling feeling on your hands or feet, your doctor needs to run a test for diabetes. The A1C is the most popular and best examine to check if you have diabetes or are at risk of getting it.
The AIC test is different and we sometimes nickname it “El Chismoso” (The Gossip) because it tells on you. If you ARE NOT diabetic but think you might be or if it runs in your family, it is very important to get screened. Either way, if you are close to being diabetic or your number is high, you need to make changes to your nutrition and exercise so you can avoid complications such as blindness, amputations, heart attack, stroke, kidney failure, and other complications. This test is also called glycated hemoglobin, glycosylated hemoglobin and HbA1c, but for short, it is simply called “A1C”. An international committee of diabetes experts recommended in 2009 that the A1C be used to diagnose both Type 1 and Type 2 diabetes, and prediabetes.
Usually you must request the A1C from your doctor as doctors do not usually volunteer to recommend one, unless you tell them of your risks including diabetes running in your family or if you are obese. Your doctor may order a Fasting Plasma Glucose Test or Casual Plasma Glucose to confirm the diagnosis of type 2 diabetes. Aside from the A1C, this is a preferred method for diagnosing diabetes because it is easy to do, convenient, and less expensive than other tests. This test is usually done only during pregnancy to diagnose gestational diabetes or for a pregnant woman who is suspected of having type 2 diabetes but have a normal fasting glucose level. It is important for people with diabetes to have a dilated eye exam at least once a year as part of their complete eye exam.
A foot exam once or twice a year, or at every doctor’s visit is also key to detect decreased circulation and sores that may not be healing.
Talk to your doctor about your child’s risk for diabetes, especially if they are overweight or if you have diabetes. This entry was posted in Charts and Graphs and tagged Average BG value by A1C, diabetes diagnosis chart.
About LizzyLouWhen I was diagnosed, I was told “you are diabetic”, given a prescription for some medication, and told to wait for a nurse to come in and give me an insulin shot.
HNF-4α controlling many genes involved in liver function such as the GLUT2 and L-PK genes. Evidence on the mode of action of metformin shows that it improves insulin sensitivity by increasing insulin receptor tyrosine kinase activity and enhancing glycogen synthesis in hepatocytes, and by increasing recruitment and transport of GLUT4 transporters to the plasma membrane in adipose tissue. In addition to its effects on hepatic glucose and lipid homeostasis and adipose tissue lipid homeostasis, metformin exerts effects in the pancreas, vascular endothelial cells, and in cancer cells.
The final destination of a journey is not, after all, the last item on the agenda, but rather some understanding, however simple or provisional, of what one has seen. In these modern times, with the plethora of blood-sugar-related diseases, we need tools like GI and GL to help us understand ways to control blood sugar.
The self-testing, graphic approach to food testing developed in the balance of the newsletter is a less scientific but a more dynamic way to explore postprandial (post-meal) blood glucose levels (BGLs). GI measures the blood glucose impact of foods eaten in isolation, yet we rarely consume foods this way. GI readings vary with the individual—blood sugar and insulin reactions are more extreme for diabetics, for example (See Charts 2A and 2B).
GIs are calculated in the science lab as the day’s first meal after a 12-hour fast and using a fixed serving that includes 50 grams of carbohydrate.  Most of our daily calories, however, are consumed in combination and throughout the day, when our blood sugar is affected by other foods that we have eaten earlier, as well as by our level of activity. Of the following numbered charts, the first three are based upon scientific research journal articles (Charts 1, 2A, 2B), while the last four (Charts 3-6) are constructed from my own self-testing of foods4 using a simple blood glucose monitor. Chart 1:  Blood Sugar Curves of White Bread Compared to Bread with Added Fiber, Sourdough, and Vinegar. Chart 3:  Instant Oatmeal, Whole Oats (Soaked and Not Soaked), and Whole Oats Combined with a Protein and Fat. To fully appreciate the impact of two back-to-back carbohydrate breakfasts please notice that the scale used for Chart 6 is twice that of Charts 3-5.


Resetting the Table–to Control Blood Sugar (For a discussion of other strategies, see April 2011). Ramekins filled with condiments like nuts and seeds (GI=0).  Nuts and seeds provide healthy fats, fiber, vitamins, minerals, and antioxidants, while they slow digestion and curb blood sugar.
Sourdough bread or whole-grain bread with whole kernels; butter from grass-fed cows and organic nut and seed butters such as tahini and pumpkin seed butter. A pitcher of water and glasses for all—sometimes we mistake hunger for what is in fact thirst.  You might flavor the water with a little lemon juice or other flavoring. Because 12-hour fasting, pre-meal blood sugar reading can vary, all data points at time zero prior to the first morning meal were indexed to zero in order to illustrate the change from a neutral starting point. I use the label “traditional” carbohydrates, just as we call unrefined fats, “traditional” fats. The real story is that the number, size, and density of cholesterol particles in your blood (LDL-P and HDL-P) are far better predictors of heart disease risk.
The best way to measure your heart disease risk through LDL cholesterol is to measure the number of LDL particles in your blood, or LDL-P, which you never get checked unless you have a fancy test called a lipid nuclear magnetic resonance test – or NMR test for short. You can look at particle size.  As a general rule (this is NOT always the case, however), the larger the LDL particles, for a given LDL-C, the fewer the particles (which is what we want). Below is graph of my overall change in changes in HDL-C, LDL-C, and TG, along with the ratio of my TG to HDL-C, based on the “standard” cholesterol panel. As I stated above, a better marker of risk with respect to LDL is particle number, LDL-P – the fewer particles, the better; and you can estimate this by measuring particle size, or through concentration of ApoB. Unfortunately, I only started doing regular VAP testing about a year ago, over one year into my “experiment” of progressive carbohydrate restriction.  Hence, I can’t show my progress as longitudinally with VAP as I can with standard cholesterol testing. Below is figure showing the change in my VAP panel over a seven month period, between January and July 2011. Keep in mind how my diet changed between January and July – I reduced carbohydrate intake from approximately 150 grams per day of “good” carbs to less than 50 grams per day.  I also increased, dramatically, my intake of fat, including saturated fats.
Despite the amount of time I’ve expended on explaining all of these nuances of “cholesterol” numbers, I am not entirely convinced that I am healthier today because my cholesterol numbers are better.  I wonder if I’m healthier today because of something else, and that whatever else is making me healthier is also correcting my cholesterol problem? If I had to guess what is really making me healthier today, besides being less fat, I believe it is the combination of how sensitive I’ve become to insulin and how much less inflammation I have in my body, especially in and around my arteries. As I mentioned above, findings #1, 2, and 4 are almost universal in folks who abandon carbohydrates, while finding #3 is somewhat variable. Which of these is most important?  This is an obvious and important question, but one I don’t really know the answer to (nor does anyone else, for that matter).  If I had to guess, I believe observation #4 is the most important because insulin resistance is the underpinning of metabolic syndrome. People have said things to me like, “Well it’s great that you’ve reduced your risk of all diseases associated with metabolic syndrome, but wouldn’t it be funny if you got hit by a car tomorrow!”  All kidding aside, this misses the point. I’ve been testing fasting blood glucose, and one and two hour post meal, the detailed results of which I’ll share in a future post. This measures how much glucose permanently gets glycated (bonded) to hemoglobin in red blood cells.
I'm a big believer in sustainability, and am a bit nutty about optimizing my diet, supplements, hormones and exercise.
Alcohol and snacking (assuming the snacks are high glycemic) will boost blood sugar and over time that could cause insulin resistance. It tells you what your average blood sugar level is for the past 90 days; 3 months, giving a much better picture of your average daily blood sugar levels. This test can tell you for sure if you are or not, or warn you if you are getting close to being pre-diabetic so you can make changes to your lifestyle. Chronically elevated blood glucose can lead to serious complications, such as damage to the cardiovascular system, nerves, kidneys and eyes. If you have Type 2 diabetes that does not require insulin, and your blood sugar is regularly under control, the test is usually taken twice a year.
If you do not have health insurance, you can call “211” for referral to a low-cost clinic or find a clinic in the Latino Diabetes Association Low-Cost or Free Community Clinic Directory.
This can detect early signs of Diabetes Retinopathy, which is the leading cause of blindness in the U.S. Early detection of eye and foot problems in diabetes allows your doctor to prescribe proper treatment. Most of the time, diabetes is discovered when a blood or urine test taken for other health problems shows the presence of diabetes. If your child’s blood sugar tests are higher than normal, but not yet at the level of diabetes (called prediabetes), ask your doctor for a specific diet and exercises to prevent your child from getting diabetes. When I picked up the prescription I was given a 10-page booklet telling me “All About How to Mange Diabetes”, and sent on my way. This blog is to share my experiences and anything I write is in no way intended to be taken as medical advice.
Another exenatide-related drug is Bydureon® which is a once-a-week injectable form of exenatide. A more recent addition to the GLP-1 receptor agonist family of diabetes drugs is Trulicity® (dulaglutide) manufactured by Eli Lilly and Co. Additionally, it has been shown that metformin affects mitochondrial activities dependent upon the model system studied.
The latter effects of metformin were recognized in epidemiological studies of diabetic patients taking metformin versus those who were taking another anti-hyperglycemia drug.


The second factor—the postwar shift from traditional to refined carbohydrates—is largely due to the growing role of the commercial food industry and processed, convenience foods.  Convenience foods must have a long shelf-life, so food companies rely upon refined flours and oils, which do not go rancid.
Visual pictures of postprandial blood sugar behavior, while less scientific than GI measurements, are nevertheless powerful learning tools, providing a real flavor for how our body reacts when we eat different kinds of foods.
This chart illustrates the second meal effect– that what we eat at one meal affects postprandial blood sugar behavior at the next. What we do to our children when we give them a sugary cereal or a Pop-tart for breakfast extends beyond this first meal to affect their blood sugar, hunger, concentration, and desire to overeat throughout the rest of the day. One of the best herbs and spices to moderate blood sugar.  It can be sprinkled on hot cereals and desserts such as puddings, custards, and stewed fruits. Well, there are two: what can I actually measure that predicts my risk of heart disease, and how does diet affect these these things I can measure? Basically it’s a test to measure how much insulin a person needs to keep their glucose level constant, despite the addition of glucose.  The less insulin one requires, the more insulin sensitive one is. This measurement roughly indicates your average blood sugar over the previous three months, and the higher it has been over the past three months, the more likely it is that glucose (sugar) is permanently bonded to hemoglobin, which is not a good thing. He reports that it’s not uncommon for people on restricted carbohydrate diets (like me) to have high fasting glucose serum numbers.
If you legitimately are on a low-carb diet and both the post meal and A1(c) numbers are good, then it could be that your situation is accurately described by Chris’ explanation quoted above. As a comparison, using a glucose meter is very important to do every day to monitor how your blood sugar is doing, but it is limited because it can only tell you what your blood sugar is at that moment you check your blood. So if you ARE diabetic you need to know how you have been doing in the past 90 days, especially if you have not been feeling good, not taken good care of yourself, or seen your doctor in a while. By monitoring blood sugar levels over a period of months, you and your doctor can see whether you are successfully keeping your diabetes under control. For persons who are not controlling their diabetes or have just been diagnosed, the test is often ordered more frequently.
Also check your feet daily with a mirror on a carpeted floor if you cannot see the bottom of your feet. Any information here is intended to complement the relationship with your doctor, not replace it.
Metformin has a mild inhibitory effect on complex I of oxidative phosphorylation, has antioxidant properties, and activates both glucose-6-phosphate dehydrogenase, G6PDH and AMP-activated protein kinase, AMPK.
This depends on what you ate or drank, the time of day, your stress level, medications, and other factors. If you have the smallest sore or “ulcer”, see your podiatrist immediately as a serious infection like gangrene can begin in just a couple of days. The importance of AMPK in the actions of metformin stems from the role of AMPK in the regulation of both lipid and carbohydrate metabolism (see AMPK: Master Metabolic Regulator for more details).
This is why diabetes and obesity often go hand-in-hand (90% of diabetics are either overweight or obese). David Ludwig regarding high-glycemic foods and overeating, cited in the Recommended Reading section at the conclusion of this newsletter.
In adipose tissue, metformin inhibits lipolysis while enhancing re-esterification of fatty acids. If you have had uncontrolled diabetes for a long period of time, your A1C level may rise to as high as 25%. The activation of AMPK by metformin is likely related to the inhibitory effects of the drug on complex I of oxidative phosphorylation. This would lead to a reduction in ATP production and, therefore, an increase in the level of AMP and as a result activation of AMPK.
In fact, since the cells of the gut will see the highest doses of metformin they will experience the greatest level of inhibited complex I which may explain the gastrointestinal side effects (nausea, diarrhea, anorexia) of the drug that limit its utility in many patients. However, I now have a secret weapon to conquer my fear of salad. I love red onions, and I love garlic. So the two together created a delicious flavor explosion in my mouth that I just have to share..
Determined to overcome my salad challenged attitude, I began looking at various recipes on the web for chopped salads, and using several as a guide (to which I added my own twist of course) I came up with this great tasting blend of fresh corn, black beans, olives, peppers and avocado. But rest assured that this delicious looking AND TASTING vegan hamburger recipe will have you happy and feeling great about your cruelty free choice. Instead, you can join the party with something just as tasty, happy in your stance of cruelty free food choices. And though most vegan cheeses aren’t QUITE the same as cow or goat milk based cheeses, there are many commercial brands and some home made versions which definitely fill the void.
The sender was raving about the fabulousness of this mac and cheese, which I have to admit got my attention. The part I didn’t like was burning my oven for two hours to cook four patties of wheat meat.
We were surprised that such a modestly priced mix passed our taste test for vegans and omnis with flying color and a five-star rating.



Injection of insulin lower blood glucose levels
Diabetic blood sugar 22 jump
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Comments

  1. 01.01.2015 at 10:12:44


    The urine, or you urinate on the test strip effect.

    Author: 45345
  2. 01.01.2015 at 16:53:40


    Insulin in the blood and your body is forced.

    Author: SOSO
  3. 01.01.2015 at 11:14:38


    The child should receive glucose PO or an age-appropriate.

    Author: Prinsesa_Wostoka
  4. 01.01.2015 at 12:48:39


    Have been caught completely sign that you are at high risk for diabetes and helpful tips.

    Author: Juliana