I was both confounded and surprised because my diet is pretty darn excellent, particularly concerning those pesky, debilitating high glycemic carbs that proliferate the Great American Diet.
If you haven’t read My Blood Sugar Numbers Confound Me, you may wish to do so before continuing so that you can have context for the rest of this post. The first thing that occurred to me when I got my blood test results was that both my father and uncle (his brother) developed adult-onset diabetes, which is called “Type 2 Diabetes”.
I always thought that they both contracted that disease in their 60s because they ate crap, were overweight and didn’t exercise, but now I’m wondering if they had a genetic predisposition to type 2 diabetes and therefore would have gotten it even if they ate and exercised…ahh… well… like me?
As the video in “My Blood Sugar Numbers” describes, I borrowed my sister’s glucometer and began testing my blood.
In addition to the favorable post meal blood glucose numbers, I have another blood measurement marker that’s in my favor. Hemoglobin A1(c) is expressed in percentage terms because it’s measuring the percentage of hemoglobin that’s bonded to sugar. In subsequent posts, I’ll report about some other unhappy blood result I got in my last Life Extension test, such has high VLDL, Pattern B LDL Density Pattern, high inflammation markers and low thyroid indications. You're gonna get (1) the Newsletter, (2) the four-part guide, Transform Your Body and Mind, and (3) the 12 Ageproof Biohacks.
HNF-4α controlling many genes involved in liver function such as the GLUT2 and L-PK genes.
Evidence on the mode of action of metformin shows that it improves insulin sensitivity by increasing insulin receptor tyrosine kinase activity and enhancing glycogen synthesis in hepatocytes, and by increasing recruitment and transport of GLUT4 transporters to the plasma membrane in adipose tissue. In addition to its effects on hepatic glucose and lipid homeostasis and adipose tissue lipid homeostasis, metformin exerts effects in the pancreas, vascular endothelial cells, and in cancer cells. Prediabetes is a condition in which blood glucose (sugar) or A1C levels are higher than normal but not high enough to be diagnosed as diabetes. Unfortunately, since there are typically no signs or symptoms, nine out of ten people with prediabetes don’t know they have it. Despite these alarming statistics and broad risk factors, research indicates that individuals can cut their risk of getting type 2 diabetes by more than half through lifestyle modifications.
Several research studies suggest that lifestyle measures are the best way to dodge the diabetes bullet.
With just a few lifestyle adjustments, prediabetes can be reversible for some individuals, returning their blood glucose levels back to normal. Carbohydrate: About 40 percent of calories should come from carbohydrates, including at least 20-35 grams of fiber.
For the greatest benefit, aim for 60-90 minutes of moderate-intensity physical activity on most days of the week. The last column regards rules especially for type-1’s with whom numbers over 250 could involve high ketone levels. My current Meal Plan is a range of 45-60 grams of Carbs and about 33 grams of protein per Meal.
Regarding the number of carbs you should consume, only your meter can answer that question (with a lot more testing than once a day). Looks like next you have to work on keeping those numbers below 250 where it won’t be an issue. Since then, I have limited my carb intake and exercise daily which has helped me lower my BG. James this will be the third time that I’m answering your question to the extent that I’m going to! No one can tell you the effect a random high number will have on your body, no one, not your doctor or anyone else. So before going to the gym, my 1 hour post dinner BG is 173, now during my exercise, I check and its up to 211-250 (some where around there). You don’t say how long after eating you exercised, nor how long and how strenuous the exercise was.


It’s always best to avoid high numbers if possible, and going low can do damage as well.
I have had type 11 diabetes for 18 years and take insulinm Humalog (sliding scale) and Lantus at night. About LizzyLouWhen I was diagnosed, I was told “you are diabetic”, given a prescription for some medication, and told to wait for a nurse to come in and give me an insulin shot. I’ve been testing fasting blood glucose, and one and two hour post meal, the detailed results of which I’ll share in a future post.
This measures how much glucose permanently gets glycated (bonded) to hemoglobin in red blood cells.
I'm a big believer in sustainability, and am a bit nutty about optimizing my diet, supplements, hormones and exercise.
Alcohol and snacking (assuming the snacks are high glycemic) will boost blood sugar and over time that could cause insulin resistance.
Another exenatide-related drug is Bydureon® which is a once-a-week injectable form of exenatide. A more recent addition to the GLP-1 receptor agonist family of diabetes drugs is Trulicity® (dulaglutide) manufactured by Eli Lilly and Co. Additionally, it has been shown that metformin affects mitochondrial activities dependent upon the model system studied.
The latter effects of metformin were recognized in epidemiological studies of diabetic patients taking metformin versus those who were taking another anti-hyperglycemia drug. One of the most significant was The Diabetes Prevention Program (DPP), a major clinical research study, that found lifestyle modifications reduced the risk of developing type 2 diabetes by 58% over a 3 year period, while the drug metformin reduced risk by 31% overall.
The best sources include fish, skinless chicken or turkey, nonfat or low-fat dairy products, and legumes (beans and peas). Physical activity is an important component to any healthy lifestyle, but those with prediabetes can especially benefit. If you are unable to start there, try to walk briskly for at least 30 minutes a day, 5 days a week.
If you are overweight, losing 5-10% of your total weight is beneficial for improving insulin sensitivity and regulating glucose control. For type-2’s (who can also have high ketone levels with high numbers) the cut-off is higher, usually 300. Even with this, I am still struggling with sustaining my BG in the 100+ range for a full 3-4 hours.
When I picked up the prescription I was given a 10-page booklet telling me “All About How to Mange Diabetes”, and sent on my way. This blog is to share my experiences and anything I write is in no way intended to be taken as medical advice.
This measurement roughly indicates your average blood sugar over the previous three months, and the higher it has been over the past three months, the more likely it is that glucose (sugar) is permanently bonded to hemoglobin, which is not a good thing. He reports that it’s not uncommon for people on restricted carbohydrate diets (like me) to have high fasting glucose serum numbers.
If you legitimately are on a low-carb diet and both the post meal and A1(c) numbers are good, then it could be that your situation is accurately described by Chris’ explanation quoted above. Metformin has a mild inhibitory effect on complex I of oxidative phosphorylation, has antioxidant properties, and activates both glucose-6-phosphate dehydrogenase, G6PDH and AMP-activated protein kinase, AMPK. Those with prediabetes have an increased risk of developing type 2 diabetes, heart disease, and stroke. Not only does exercise help lower blood sugar levels, but it aids in weight loss which is another helpful factor in reducing your risk of developing diabetes.
Again, if that is too challenging to start, just try to be more active throughout the day, such as parking further from the store entrance or taking the stairs. Clinical Nutrition Guideline For Overweight and Obese Adults with Type 2 Diabetes, Prediabetes Or Those at High Risk For Developing Type 2 Diabetes.


My opinion is that if your numbers are higher than 250 you shouldn’t do any strenuous or prolonged exercise until they are lower than 250.
As an example after 2 hours of eating, my BG rarely gets up to between 140-180 (ADA guide).
Any information here is intended to complement the relationship with your doctor, not replace it.
The importance of AMPK in the actions of metformin stems from the role of AMPK in the regulation of both lipid and carbohydrate metabolism (see AMPK: Master Metabolic Regulator for more details). The Joslin Diabetes Center recommends achieving this goal by losing just one pound every one to two weeks through a reduction of 250 to 500 calories per day. In adipose tissue, metformin inhibits lipolysis while enhancing re-esterification of fatty acids. Currently my fasting is 90, post lunch 110, post dinner 135 (both 1 hour reading as I dont take 2 hour reading). Much like you, I test very regularly and use my Meter as a Guide during the day to help me determine how much to consume and when.
Since it was so soon after eating it might have also been what you ate and your numbers might have been high regardless.
The activation of AMPK by metformin is likely related to the inhibitory effects of the drug on complex I of oxidative phosphorylation. The issues I am currently facing are (1)post breakfast of oats my blood sugar spikes to 150(1 hour) and (2) after exercise (high intensity interval training on treadmill) it spikes to 165. I am also trying to lose weight with a goal of walking for 30 minutes a day, 5 times a week.
This would lead to a reduction in ATP production and, therefore, an increase in the level of AMP and as a result activation of AMPK. In fact, since the cells of the gut will see the highest doses of metformin they will experience the greatest level of inhibited complex I which may explain the gastrointestinal side effects (nausea, diarrhea, anorexia) of the drug that limit its utility in many patients. Now on Jul 31st, I weigh 160 lbs, am taken off blood pressure pill and cholesterol is down to 110. However, I now have a secret weapon to conquer my fear of salad. I love red onions, and I love garlic.
So the two together created a delicious flavor explosion in my mouth that I just have to share..
Determined to overcome my salad challenged attitude, I began looking at various recipes on the web for chopped salads, and using several as a guide (to which I added my own twist of course) I came up with this great tasting blend of fresh corn, black beans, olives, peppers and avocado. But rest assured that this delicious looking AND TASTING vegan hamburger recipe will have you happy and feeling great about your cruelty free choice. Instead, you can join the party with something just as tasty, happy in your stance of cruelty free food choices. And though most vegan cheeses aren’t QUITE the same as cow or goat milk based cheeses, there are many commercial brands and some home made versions which definitely fill the void. The sender was raving about the fabulousness of this mac and cheese, which I have to admit got my attention. The part I didn’t like was burning my oven for two hours to cook four patties of wheat meat. We were surprised that such a modestly priced mix passed our taste test for vegans and omnis with flying color and a five-star rating.




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