The mystery that started it all. When Olivia Dunham first came onto Fringe Division, their focus was to figure out what the Pattern was. Sure there were strange things happening that were resulting in death and destruction, but what was most disconcerting is that all these events began to form a pattern.
As the Fringe Division investigated these events, they found more and more such patterns. Many of these were related to research previously conducted by Massive Dynamic, or sometimes even to Walter Bishop himself. Special Agent-in-charge, Broyles, would go on to describe the events "...as if someone out there is experimenting, only the whole world is a lab." Eventually, there is even a geographic pattern that emerges, and dark secrets of Walter's past are forced out into the light