| City | Population | Rank | Murders Per 100,000 Residents | Violent Crimes Per 100,000 Residents | Property Crimes Per 100,000 Residents | Total Crimes Per 100,000 Residents | Chance of Crime |
| Mauldin | 23,631 | 1 | 1 | 2 | 2 | 2 | 1:46 |
| Mount Pleasant | 70,016 | 2 | 1 | 4 | 1 | 1 | 1:51 |
| Summerville | 45,209 | 3 | 10 | 1 | 7 | 7 | 1:32 |
| Simpsonville | 18,829 | 4 | 1 | 8 | 10 | 10 | 1:27 |
| Bluffton | 12,855 | 5 | 1 | 9 | 11 | 11 | 1:26 |
| Fort Mill | 11,132 | 6 | 17 | 5 | 3 | 3 | 1:45 |
| Goose Creek | 37,387 | 7 | 12 | 11 | 5 | 5 | 1:36 |
| Lexington | 18,352 | 8 | 1 | 10 | 15 | 14 | 1:23 |
| Clemson | 14,079 | 9 | 15 | 7 | 9 | 8 | 1:28 |
| Charleston | 123,856 | 10 | 20 | 6 | 6 | 6 | 1:34 |
| Port Royal | 10,893 | 11 | 17 | 12 | 4 | 4 | 1:39 |
| Greer | 26,249 | 12 | 10 | 15 | 8 | 9 | 1:28 |
| North Augusta | 21,639 | 13 | 17 | 3 | 14 | 13 | 1:23 |
| Newberry | 10,430 | 14 | 1 | 22 | 16 | 16 | 1:18 |
| Orangeburg | 14,017 | 15 | 1 | 14 | 23 | 23 | 1:15 |
| Greenville | 60,953 | 16 | 9 | 23 | 18 | 18 | 1:16 |
| Rock Hill | 68,064 | 17 | 21 | 18 | 13 | 15 | 1:23 |
| Gaffney | 12,574 | 18 | 25 | 17 | 12 | 12 | 1:24 |
| Forest Acres | 10,596 | 19 | 1 | 19 | 30 | 29 | 1:12 |
| West Columbia | 15,610 | 20 | 14 | 26 | 19 | 21 | 1:16 |
| Aiken | 29,909 | 21 | 28 | 13 | 21 | 17 | 1:17 |
| North Charleston | 100,675 | 22 | 22 | 20 | 22 | 22 | 1:16 |
| Easley | 20,249 | 23 | 24 | 16 | 25 | 24 | 1:14 |
| Cayce | 12,864 | 24 | 28 | 21 | 20 | 19 | 1:16 |
| Spartanburg | 37,689 | 25 | 12 | 29 | 26 | 28 | 1:12 |
| Sumter | 40,911 | 26 | 27 | 27 | 17 | 20 | 1:16 |
| Florence | 37,681 | 27 | 16 | 24 | 29 | 27 | 1:12 |
| Beaufort | 12,653 | 28 | 25 | 28 | 24 | 25 | 1:13 |
| Greenwood | 23,564 | 29 | 22 | 30 | 28 | 30 | 1:11 |
| Anderson | 27,127 | 30 | 31 | 25 | 27 | 26 | 1:12 |
| Myrtle Beach | 28,085 | 31 | 30 | 31 | 31 | 31 | 1:6 |