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"id": "CID:49841217",
"label": "avacopan",
"IDG_ID": "5494",
"uri": "https://pubchem.ncbi.nlm.nih.gov/compound/49841217",
"SMILES": "CC1=C(C(=CC=C1)F)C(=O)N2CCCC(C2C3=CC=C(C=C3)NC4CCCC4)C(=O)NC5=CC(=C(C=C5)C)C(F)(F)F",
"InChI_key": "PUKBOVABABRILL-YZNIXAGQSA-N"
}
},
"728": {
"type": "Gene",
"properties": {
"id": "728",
"label": "C5AR1",
"target_name": "C5a anaphylatoxin chemotactic receptor 1",
"target_class": "GPCR",
"accession": "P21730",
"swissprot": "C5AR1_HUMAN",
"organism": "Homo sapiens",
"TDL": "Tchem",
"pLI": 0.0004163655017778,
"Residual_Variation_Intolerance_Score": -0.598810865184194,
"Residual_Variation_Intolerance_Score_Percentile": 18.1351733899505,
"pHI": 0.18444,
"pTS": 0.2803
}
},
"CID:72165228": {
"type": "Drug",
"properties": {
"id": "CID:72165228",
"label": "abl-001",
"IDG_ID": "5495",
"uri": "https://pubchem.ncbi.nlm.nih.gov/compound/72165228",
"SMILES": "C1CN(CC1O)C2=C(C=C(C=N2)C(=O)NC3=CC=C(C=C3)OC(F)(F)Cl)C4=CC=NN4",
"InChI_key": "VOVZXURTCKPRDQ-CQSZACIVSA-N"
}
},
"CID:164512668": {
"type": "Drug",
"properties": {
"id": "CID:164512668",
"label": "pafolacianine",
"smiles": "CC1(C)\\C(=C/C=C2\\CCCC(\\C=C\\C3=[N+](CCCCS(O)(=O)=O)C4=CC=C(C=C4C3(C)C)S(O)(=O)=O)=C2OC2=CC=C(C[C@H](NC(=O)C3=CC=C(NCC4=NC5=C(N=C4)N=C(N)NC5=O)C=C3)C(O)=O)C=C2)N(CCCCS(O)(=O)=O)C2=CC=C(C=C12)S(O)(=O)=O",
"IDG_ID": "5497",
"uri": "https://pubchem.ncbi.nlm.nih.gov/compound/164512668"
}
},
"CID:73330464": {
"type": "Drug",
"properties": {
"id": "CID:73330464",
"label": "diroximel fumarate",
"IDG_ID": "5502",
"uri": "https://pubchem.ncbi.nlm.nih.gov/compound/73330464",
"SMILES": "COC(=O)C=CC(=O)OCCN1C(=O)CCC1=O",
"InChI_key": "YIMYDTCOUQIDMT-SNAWJCMRSA-N"
}
},
"CID:57855696": {
"type": "Drug",
"properties": {
"id": "CID:57855696",
"label": "difamilast",
"IDG_ID": "5503",
"uri": "https://pubchem.ncbi.nlm.nih.gov/compound/57855696",
"SMILES": "CCOC1=CC=CC=C1C(=O)NCC2=COC(=N2)C3=CC(=C(C=C3)OC(F)F)OC(C)C",
"InChI_key": "VFBILHPIHUPBPZ-UHFFFAOYSA-N"
}
},
"CID:78323835": {
"type": "Drug",
"properties": {
"id": "CID:78323835",
"label": "abrocitinib",
"IDG_ID": "5504",
"uri": "https://pubchem.ncbi.nlm.nih.gov/compound/78323835",
"InChI_key": "IUEWXNHSKRWHDY-PHIMTYICSA-N"
}
}
},
"edges": [
{
"source": "CID:92253",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "levobupivacaine targets CYP2D6",
"source_label": "levobupivacaine",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.707",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:157702",
"relation": "IDG (Drug Target)",
"target": "776",
"properties": {
"id": "(S)-nitrendipine targets CACNA1D",
"source_label": "(S)-nitrendipine",
"target_label": "CACNA1D",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "Recombinant Cav1.3 calcium channel complexes expressed in tsA-cells",
"act_source": "IUPHAR"
}
},
{
"source": "CID:157702",
"relation": "IDG (Drug Target)",
"target": "3783",
"properties": {
"id": "(S)-nitrendipine targets KCNN4",
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"target_label": "KCNN4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9444",
"relation": "IDG (Drug Target)",
"target": "1786",
"properties": {
"id": "azacitidine targets DNMT1",
"source_label": "azacitidine",
"target_label": "DNMT1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4114",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "methoxsalen targets ACHE",
"source_label": "methoxsalen",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Inhibition of acetylcholinesterase (unknown origin) using acetylcholine iodide as substrate preincubated for 15 mins prior to substrate addition by spectrophotometric analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4114",
"relation": "IDG (Drug Target)",
"target": "1544",
"properties": {
"id": "methoxsalen targets CYP1A2",
"source_label": "methoxsalen",
"target_label": "CYP1A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.398",
"act_comment": "DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:16131215",
"relation": "IDG (Drug Target)",
"target": "2798",
"properties": {
"id": "abarelix targets GNRHR",
"source_label": "abarelix",
"target_label": "GNRHR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.49",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:444254",
"relation": "IDG (Drug Target)",
"target": "276",
"properties": {
"id": "acarbose targets AMY1A",
"source_label": "acarbose",
"target_label": "AMY1A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Inhibition of human salivary alpha-amylase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:444254",
"relation": "IDG (Drug Target)",
"target": "6476",
"properties": {
"id": "acarbose targets SI",
"source_label": "acarbose",
"target_label": "SI",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.609",
"act_comment": "C-terminal catalytic subunit",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:1978",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "acebutolol targets ADRB1",
"source_label": "acebutolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
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},
{
"source": "CID:1978",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "acebutolol targets ADRB2",
"source_label": "acebutolol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:54676537",
"relation": "IDG (Drug Target)",
"target": "79001",
"properties": {
"id": "acenocoumarol targets VKORC1",
"source_label": "acenocoumarol",
"target_label": "VKORC1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.114",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:904",
"relation": "IDG (Drug Target)",
"target": "93100",
"properties": {
"id": "acetanilide targets NAPRT",
"source_label": "acetanilide",
"target_label": "NAPRT",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "Inhibition of NAPRT (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1986",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "acetazolamide targets CA1",
"source_label": "acetazolamide",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1986",
"relation": "IDG (Drug Target)",
"target": "770",
"properties": {
"id": "acetazolamide targets CA11",
"source_label": "acetazolamide",
"target_label": "CA11",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.24",
"act_comment": "Inhibition of recombinant human membrane bound carbonic anhydrase 11 expressed in Escherichia coli pretreated for 15 mins prior to testing by stopped-flow assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1986",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "acetazolamide targets CA12",
"source_label": "acetazolamide",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.6",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 12 catalytic domain preincubated for 15 mins by CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1986",
"relation": "IDG (Drug Target)",
"target": "377677",
"properties": {
"id": "acetazolamide targets CA13",
"source_label": "acetazolamide",
"target_label": "CA13",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.24",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 13 preincubated for 15 mins by CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1986",
"relation": "IDG (Drug Target)",
"target": "23632",
"properties": {
"id": "acetazolamide targets CA14",
"source_label": "acetazolamide",
"target_label": "CA14",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.39",
"act_comment": "Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1986",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "acetazolamide targets CA2",
"source_label": "acetazolamide",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.48",
"act_comment": "Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1986",
"relation": "IDG (Drug Target)",
"target": "761",
"properties": {
"id": "acetazolamide targets CA3",
"source_label": "acetazolamide",
"target_label": "CA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.51",
"act_comment": "Inhibition of human carbonic anhydrase 3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1986",
"relation": "IDG (Drug Target)",
"target": "762",
"properties": {
"id": "acetazolamide targets CA4",
"source_label": "acetazolamide",
"target_label": "CA4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Inhibition of human secreted carbonic anhydrase 4 measured by CO2 hydration reaction assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1986",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "acetazolamide targets CA5A",
"source_label": "acetazolamide",
"target_label": "CA5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.22",
"act_comment": "Inhibition of recombinant human mitochondrial isozyme CA VA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1986",
"relation": "IDG (Drug Target)",
"target": "11238",
"properties": {
"id": "acetazolamide targets CA5B",
"source_label": "acetazolamide",
"target_label": "CA5B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.27",
"act_comment": "Inhibitory activity against human recombinant mitochondrial isozyme CA VB",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1986",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "acetazolamide targets CA6",
"source_label": "acetazolamide",
"target_label": "CA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Inhibition of full length human recombinant CA VI",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1986",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "acetazolamide targets CA7",
"source_label": "acetazolamide",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.6",
"act_comment": "Ki value against human carbonic anhydrase VII",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1986",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "acetazolamide targets CA9",
"source_label": "acetazolamide",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 9 catalytic domain expressed in Escherichia coli by stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:107751",
"relation": "IDG (Drug Target)",
"target": "1636",
"properties": {
"id": "racecadotril targets ACE",
"source_label": "racecadotril",
"target_label": "ACE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:107751",
"relation": "IDG (Drug Target)",
"target": "1889",
"properties": {
"id": "racecadotril targets ECE1",
"source_label": "racecadotril",
"target_label": "ECE1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:107751",
"relation": "IDG (Drug Target)",
"target": "4311",
"properties": {
"id": "racecadotril targets MME",
"source_label": "racecadotril",
"target_label": "MME",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "Inhibition of human NEP-mediated amyloid beta hydrolysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:94320",
"relation": "IDG (Drug Target)",
"target": "3290",
"properties": {
"id": "acetoxolone targets HSD11B1",
"source_label": "acetoxolone",
"target_label": "HSD11B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Inhibition of human recombinant 11-beta-HSD1 expressed in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:94320",
"relation": "IDG (Drug Target)",
"target": "3291",
"properties": {
"id": "acetoxolone targets HSD11B2",
"source_label": "acetoxolone",
"target_label": "HSD11B2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Inhibition of human recombinant 11-beta-HSD2 expressed in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:187",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "acetylcholine targets CHRM1",
"source_label": "acetylcholine",
"target_label": "CHRM1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Activation of M1-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signal",
"act_source": "CHEMBL"
}
},
{
"source": "CID:187",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "acetylcholine targets CHRM2",
"source_label": "acetylcholine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:187",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "acetylcholine targets CHRM3",
"source_label": "acetylcholine",
"target_label": "CHRM3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Activation of M3-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signal",
"act_source": "CHEMBL"
}
},
{
"source": "CID:187",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "acetylcholine targets CHRM5",
"source_label": "acetylcholine",
"target_label": "CHRM5",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Activation of M5-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signal",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2244",
"relation": "IDG (Drug Target)",
"target": "93100",
"properties": {
"id": "acetylsalicylic acid targets NAPRT",
"source_label": "acetylsalicylic acid",
"target_label": "NAPRT",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "Inhibition of NAPRT (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:451415",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "aclarubicin targets HTR2B",
"source_label": "aclarubicin",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.152",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5284514",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "acrivastine targets HRH1",
"source_label": "acrivastine",
"target_label": "HRH1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.16",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60164",
"relation": "IDG (Drug Target)",
"target": "5915",
"properties": {
"id": "adapalene targets RARB",
"source_label": "adapalene",
"target_label": "RARB",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.47",
"act_comment": "Binding affinity towards Retinoic acid receptor beta",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60164",
"relation": "IDG (Drug Target)",
"target": "5916",
"properties": {
"id": "adapalene targets RARG",
"source_label": "adapalene",
"target_label": "RARG",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Binding affinity towards Retinoic acid receptor gamma",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60961",
"relation": "IDG (Drug Target)",
"target": "132",
"properties": {
"id": "adenosine targets ADK",
"source_label": "adenosine",
"target_label": "ADK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60961",
"relation": "IDG (Drug Target)",
"target": "134",
"properties": {
"id": "adenosine targets ADORA1",
"source_label": "adenosine",
"target_label": "ADORA1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.509",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60961",
"relation": "IDG (Drug Target)",
"target": "135",
"properties": {
"id": "adenosine targets ADORA2A",
"source_label": "adenosine",
"target_label": "ADORA2A",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.155",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60961",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "adenosine targets ADORA3",
"source_label": "adenosine",
"target_label": "ADORA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5957",
"relation": "IDG (Drug Target)",
"target": "2840",
"properties": {
"id": "adenosine triphosphate targets GPR17",
"source_label": "adenosine triphosphate",
"target_label": "GPR17",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.43",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5957",
"relation": "IDG (Drug Target)",
"target": "5023",
"properties": {
"id": "adenosine triphosphate targets P2RX1",
"source_label": "adenosine triphosphate",
"target_label": "P2RX1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.25",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5957",
"relation": "IDG (Drug Target)",
"target": "5025",
"properties": {
"id": "adenosine triphosphate targets P2RX4",
"source_label": "adenosine triphosphate",
"target_label": "P2RX4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5957",
"relation": "IDG (Drug Target)",
"target": "5028",
"properties": {
"id": "adenosine triphosphate targets P2RY1",
"source_label": "adenosine triphosphate",
"target_label": "P2RY1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "Agonist activity at human GFP-tagged P2Y1R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5957",
"relation": "IDG (Drug Target)",
"target": "5029",
"properties": {
"id": "adenosine triphosphate targets P2RY2",
"source_label": "adenosine triphosphate",
"target_label": "P2RY2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5957",
"relation": "IDG (Drug Target)",
"target": "5030",
"properties": {
"id": "adenosine triphosphate targets P2RY4",
"source_label": "adenosine triphosphate",
"target_label": "P2RY4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "GRAC: human P2Y4 selective antagonist",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6083",
"relation": "IDG (Drug Target)",
"target": "2203",
"properties": {
"id": "adenosine phosphate targets FBP1",
"source_label": "adenosine phosphate",
"target_label": "FBP1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Inhibition of FBPase in human liver using fructose-2,6phosphate as a substrate",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6083",
"relation": "IDG (Drug Target)",
"target": "6714",
"properties": {
"id": "adenosine phosphate targets SRC",
"source_label": "adenosine phosphate",
"target_label": "SRC",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Inhibition of p60c-src expressed in chick embryo fibroblast",
"act_source": "CHEMBL"
}
},
{
"source": "CID:37632",
"relation": "IDG (Drug Target)",
"target": "706",
"properties": {
"id": "adinazolam targets TSPO",
"source_label": "adinazolam",
"target_label": "TSPO",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:82148",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "agomelatine targets HTR2B",
"source_label": "agomelatine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:82148",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "agomelatine targets HTR2C",
"source_label": "agomelatine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:82148",
"relation": "IDG (Drug Target)",
"target": "4543",
"properties": {
"id": "agomelatine targets MTNR1A",
"source_label": "agomelatine",
"target_label": "MTNR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.22",
"act_comment": "Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:82148",
"relation": "IDG (Drug Target)",
"target": "4544",
"properties": {
"id": "agomelatine targets MTNR1B",
"source_label": "agomelatine",
"target_label": "MTNR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.0",
"act_comment": "Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16667686",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "ajmaline targets CYP2D6",
"source_label": "ajmaline",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:16667686",
"relation": "IDG (Drug Target)",
"target": "3741",
"properties": {
"id": "ajmaline targets KCNA5",
"source_label": "ajmaline",
"target_label": "KCNA5",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "Activity measured in mammalian cell line",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:16667686",
"relation": "IDG (Drug Target)",
"target": "3752",
"properties": {
"id": "ajmaline targets KCND3",
"source_label": "ajmaline",
"target_label": "KCND3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.58",
"act_comment": "Activity measured in mammalian cell line",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:21158560",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "alcuronium targets CHRM2",
"source_label": "alcuronium",
"target_label": "CHRM2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5839",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "aldosterone targets NR3C2",
"source_label": "aldosterone",
"target_label": "NR3C2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.42",
"act_comment": "Agonist activity at mineralocorticoid receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5839",
"relation": "IDG (Drug Target)",
"target": "866",
"properties": {
"id": "aldosterone targets SERPINA6",
"source_label": "aldosterone",
"target_label": "SERPINA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2088",
"relation": "IDG (Drug Target)",
"target": "2224",
"properties": {
"id": "alendronic acid targets FDPS",
"source_label": "alendronic acid",
"target_label": "FDPS",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.35",
"act_comment": "Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2088",
"relation": "IDG (Drug Target)",
"target": "2342",
"properties": {
"id": "alendronic acid targets FNTB",
"source_label": "alendronic acid",
"target_label": "FNTB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.301",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2090",
"relation": "IDG (Drug Target)",
"target": "114971",
"properties": {
"id": "alexidine targets PTPMT1",
"source_label": "alexidine",
"target_label": "PTPMT1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.97",
"act_comment": "Activity measured in the presence of substrate O-MFP in an in vitro assay",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:51263",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "alfentanil targets OPRM1",
"source_label": "alfentanil",
"target_label": "OPRM1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2092",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "alfuzosin targets ACHE",
"source_label": "alfuzosin",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.75",
"act_comment": "Inhibition of AChE (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2092",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "alfuzosin targets ADRA1A",
"source_label": "alfuzosin",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.09",
"act_comment": "Binding affinity against Alpha-1A adrenergic receptor from human clone",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2092",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "alfuzosin targets ADRA1B",
"source_label": "alfuzosin",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.55",
"act_comment": "Binding affinity against Alpha-1B adrenergic receptor from human clone",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2092",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "alfuzosin targets ADRA1D",
"source_label": "alfuzosin",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.44",
"act_comment": "Binding affinity against Alpha-1D adrenergic receptor, from human clones.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5493444",
"relation": "IDG (Drug Target)",
"target": "5972",
"properties": {
"id": "aliskiren targets REN",
"source_label": "aliskiren",
"target_label": "REN",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.22",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:43008",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "alizapride targets ADRA2C",
"source_label": "alizapride",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:43008",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "alizapride targets DRD2",
"source_label": "alizapride",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:123606",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "almotriptan targets HTR1B",
"source_label": "almotriptan",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:123606",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "almotriptan targets HTR1D",
"source_label": "almotriptan",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:123606",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "almotriptan targets HTR1F",
"source_label": "almotriptan",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2099",
"relation": "IDG (Drug Target)",
"target": "1544",
"properties": {
"id": "alosetron targets CYP1A2",
"source_label": "alosetron",
"target_label": "CYP1A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.218",
"act_comment": "DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2099",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "alosetron targets HTR2B",
"source_label": "alosetron",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.194",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2099",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "alosetron targets HTR3A",
"source_label": "alosetron",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "Binding affinity to human HT3A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:73707426",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "alfacalcidol targets SLC6A2",
"source_label": "alfacalcidol",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:54897",
"relation": "IDG (Drug Target)",
"target": "706",
"properties": {
"id": "alpidem targets TSPO",
"source_label": "alpidem",
"target_label": "TSPO",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "Inhibition of TSPO (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2119",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "alprenolol targets ADRB1",
"source_label": "alprenolol",
"target_label": "ADRB1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.678",
"act_comment": "radioligand [3H]CGP12177 0.15nM competition binding; human recombinant beta-adrenoreceptors in Sf9 cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:2119",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "alprenolol targets ADRB2",
"source_label": "alprenolol",
"target_label": "ADRB2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.658",
"act_comment": "radioligand [3H]CGP12177 0.15nM competition binding; human recombinant beta-adrenoceptors in Sf9 cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:2119",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "alprenolol targets ADRB3",
"source_label": "alprenolol",
"target_label": "ADRB3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.86",
"act_comment": "Displacement of [3H]-CGP 12177 from human beta-3 adrenergic receptor expressed in CHOK1 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2119",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "alprenolol targets HTR1A",
"source_label": "alprenolol",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.67",
"act_comment": "Displacement of [3H]-OH-DPAT from human recombinant 5-HT1A receptor measured after 60 mins by scintillation counter method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280723",
"relation": "IDG (Drug Target)",
"target": "117144",
"properties": {
"id": "alprostadil targets CATSPER1",
"source_label": "alprostadil",
"target_label": "CATSPER1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Patch clamp electrophysiology",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5280723",
"relation": "IDG (Drug Target)",
"target": "117155",
"properties": {
"id": "alprostadil targets CATSPER2",
"source_label": "alprostadil",
"target_label": "CATSPER2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Patch clamp electrophysiology.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5280723",
"relation": "IDG (Drug Target)",
"target": "347732",
"properties": {
"id": "alprostadil targets CATSPER3",
"source_label": "alprostadil",
"target_label": "CATSPER3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Patch clamp electrophysiology.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5280723",
"relation": "IDG (Drug Target)",
"target": "378807",
"properties": {
"id": "alprostadil targets CATSPER4",
"source_label": "alprostadil",
"target_label": "CATSPER4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Patch clamp electrophysiology.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5280723",
"relation": "IDG (Drug Target)",
"target": "5729",
"properties": {
"id": "alprostadil targets PTGDR",
"source_label": "alprostadil",
"target_label": "PTGDR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5280723",
"relation": "IDG (Drug Target)",
"target": "5731",
"properties": {
"id": "alprostadil targets PTGER1",
"source_label": "alprostadil",
"target_label": "PTGER1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5280723",
"relation": "IDG (Drug Target)",
"target": "5732",
"properties": {
"id": "alprostadil targets PTGER2",
"source_label": "alprostadil",
"target_label": "PTGER2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5280723",
"relation": "IDG (Drug Target)",
"target": "5733",
"properties": {
"id": "alprostadil targets PTGER3",
"source_label": "alprostadil",
"target_label": "PTGER3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5280723",
"relation": "IDG (Drug Target)",
"target": "5734",
"properties": {
"id": "alprostadil targets PTGER4",
"source_label": "alprostadil",
"target_label": "PTGER4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5280723",
"relation": "IDG (Drug Target)",
"target": "5739",
"properties": {
"id": "alprostadil targets PTGIR",
"source_label": "alprostadil",
"target_label": "PTGIR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5488548",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "alvimopan targets OPRD1",
"source_label": "alvimopan",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Displacement of [3H]diprenorphine from human cloned delta opioid receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5488548",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "alvimopan targets OPRK1",
"source_label": "alvimopan",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Displacement of [3H]diprenorphine from human cloned kappa opioid receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5488548",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "alvimopan targets OPRM1",
"source_label": "alvimopan",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.398",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2130",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "amantadine targets SIGMAR1",
"source_label": "amantadine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.69",
"act_comment": "Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2132",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "ambroxol targets CYP2D6",
"source_label": "ambroxol",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.254",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2141",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "amifostine targets DRD3",
"source_label": "amifostine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.184",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:16231",
"relation": "IDG (Drug Target)",
"target": "6337",
"properties": {
"id": "amiloride targets SCNN1A",
"source_label": "amiloride",
"target_label": "SCNN1A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:7019",
"relation": "IDG (Drug Target)",
"target": "4835",
"properties": {
"id": "aminoacridine targets NQO2",
"source_label": "aminoacridine",
"target_label": "NQO2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Inhibition of recombinant human NQO2 expressed in Escherichia coli using DCPIP as substrate by spectrophotometry",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6009",
"relation": "IDG (Drug Target)",
"target": "93100",
"properties": {
"id": "aminophenazone targets NAPRT",
"source_label": "aminophenazone",
"target_label": "NAPRT",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "Inhibition of NAPRT (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1533",
"relation": "IDG (Drug Target)",
"target": "4843",
"properties": {
"id": "aminopicoline targets NOS2",
"source_label": "aminopicoline",
"target_label": "NOS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2157",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "amiodarone targets ADRA2A",
"source_label": "amiodarone",
"target_label": "ADRA2A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2157",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "amiodarone targets CHRM1",
"source_label": "amiodarone",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.201",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2157",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "amiodarone targets CHRM3",
"source_label": "amiodarone",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.168",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2157",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "amiodarone targets CHRM4",
"source_label": "amiodarone",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.296",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2157",
"relation": "IDG (Drug Target)",
"target": "1559",
"properties": {
"id": "amiodarone targets CYP2C9",
"source_label": "amiodarone",
"target_label": "CYP2C9",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.398",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2157",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "amiodarone targets CYP3A4",
"source_label": "amiodarone",
"target_label": "CYP3A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2157",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "amiodarone targets DRD3",
"source_label": "amiodarone",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.387",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2157",
"relation": "IDG (Drug Target)",
"target": "10682",
"properties": {
"id": "amiodarone targets EBP",
"source_label": "amiodarone",
"target_label": "EBP",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2157",
"relation": "IDG (Drug Target)",
"target": "2534",
"properties": {
"id": "amiodarone targets FYN",
"source_label": "amiodarone",
"target_label": "FYN",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.088",
"act_comment": "DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr))",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2157",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "amiodarone targets HTR2B",
"source_label": "amiodarone",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.231",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2157",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "amiodarone targets HTR2C",
"source_label": "amiodarone",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.674",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2157",
"relation": "IDG (Drug Target)",
"target": "3743",
"properties": {
"id": "amiodarone targets KCNA7",
"source_label": "amiodarone",
"target_label": "KCNA7",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2157",
"relation": "IDG (Drug Target)",
"target": "6331",
"properties": {
"id": "amiodarone targets SCN5A",
"source_label": "amiodarone",
"target_label": "SCN5A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2157",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "amiodarone targets SIGMAR1",
"source_label": "amiodarone",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2157",
"relation": "IDG (Drug Target)",
"target": "55145",
"properties": {
"id": "amiodarone targets THAP1",
"source_label": "amiodarone",
"target_label": "THAP1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2157",
"relation": "IDG (Drug Target)",
"target": "7068",
"properties": {
"id": "amiodarone targets THRB",
"source_label": "amiodarone",
"target_label": "THRB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2159",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "amisulpride targets DRD2",
"source_label": "amisulpride",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.553",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2159",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "amisulpride targets DRD3",
"source_label": "amisulpride",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.495",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "amitriptyline targets ADRA1A",
"source_label": "amitriptyline",
"target_label": "ADRA1A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "amitriptyline targets ADRA1D",
"source_label": "amitriptyline",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.252",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "amitriptyline targets ADRA2A",
"source_label": "amitriptyline",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.879",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "amitriptyline targets ADRA2B",
"source_label": "amitriptyline",
"target_label": "ADRA2B",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "amitriptyline targets ADRA2C",
"source_label": "amitriptyline",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.066",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "316",
"properties": {
"id": "amitriptyline targets AOX1",
"source_label": "amitriptyline",
"target_label": "AOX1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.585",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "amitriptyline targets CHRM1",
"source_label": "amitriptyline",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.83",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "amitriptyline targets CHRM2",
"source_label": "amitriptyline",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "amitriptyline targets CHRM3",
"source_label": "amitriptyline",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "amitriptyline targets CHRM4",
"source_label": "amitriptyline",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.14",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "amitriptyline targets CHRM5",
"source_label": "amitriptyline",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "amitriptyline targets DRD1",
"source_label": "amitriptyline",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.051",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "amitriptyline targets DRD2",
"source_label": "amitriptyline",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.708",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "amitriptyline targets DRD3",
"source_label": "amitriptyline",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.686",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "amitriptyline targets DRD5",
"source_label": "amitriptyline",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "amitriptyline targets HRH1",
"source_label": "amitriptyline",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "amitriptyline targets HRH2",
"source_label": "amitriptyline",
"target_label": "HRH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "59340",
"properties": {
"id": "amitriptyline targets HRH4",
"source_label": "amitriptyline",
"target_label": "HRH4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.14",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "amitriptyline targets HTR1A",
"source_label": "amitriptyline",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.721",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "amitriptyline targets HTR2A",
"source_label": "amitriptyline",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "amitriptyline targets HTR2B",
"source_label": "amitriptyline",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "amitriptyline targets HTR2C",
"source_label": "amitriptyline",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "amitriptyline targets HTR6",
"source_label": "amitriptyline",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.05",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "amitriptyline targets HTR7",
"source_label": "amitriptyline",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "amitriptyline targets RET",
"source_label": "amitriptyline",
"target_label": "RET",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "6335",
"properties": {
"id": "amitriptyline targets SCN9A",
"source_label": "amitriptyline",
"target_label": "SCN9A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "amitriptyline targets SIGMAR1",
"source_label": "amitriptyline",
"target_label": "SIGMAR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "amitriptyline targets SLC6A2",
"source_label": "amitriptyline",
"target_label": "SLC6A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.456",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2160",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "amitriptyline targets SLC6A4",
"source_label": "amitriptyline",
"target_label": "SLC6A4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.367",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2161",
"relation": "IDG (Drug Target)",
"target": "9641",
"properties": {
"id": "amlexanox targets IKBKE",
"source_label": "amlexanox",
"target_label": "IKBKE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Inhibition of substrate phosphorylation.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2161",
"relation": "IDG (Drug Target)",
"target": "29110",
"properties": {
"id": "amlexanox targets TBK1",
"source_label": "amlexanox",
"target_label": "TBK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Inhibition of substrate phosphorylation.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2162",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "amlodipine targets ADRA2A",
"source_label": "amlodipine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.646",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2162",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "amlodipine targets ADRA2C",
"source_label": "amlodipine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.583",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2162",
"relation": "IDG (Drug Target)",
"target": "776",
"properties": {
"id": "amlodipine targets CACNA1D",
"source_label": "amlodipine",
"target_label": "CACNA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2162",
"relation": "IDG (Drug Target)",
"target": "781",
"properties": {
"id": "amlodipine targets CACNA2D1",
"source_label": "amlodipine",
"target_label": "CACNA2D1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2162",
"relation": "IDG (Drug Target)",
"target": "786",
"properties": {
"id": "amlodipine targets CACNG1",
"source_label": "amlodipine",
"target_label": "CACNG1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2162",
"relation": "IDG (Drug Target)",
"target": "3776",
"properties": {
"id": "amlodipine targets KCNK2",
"source_label": "amlodipine",
"target_label": "KCNK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Inhibition of TREK-1 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2165",
"relation": "IDG (Drug Target)",
"target": "3176",
"properties": {
"id": "amodiaquine targets HNMT",
"source_label": "amodiaquine",
"target_label": "HNMT",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "Inhibition of histamine N-methyltransferase by radiochemical assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "amoxapine targets ADRA1D",
"source_label": "amoxapine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.842",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "amoxapine targets ADRA2A",
"source_label": "amoxapine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.307",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "amoxapine targets ADRA2B",
"source_label": "amoxapine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.593",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "amoxapine targets ADRA2C",
"source_label": "amoxapine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.336",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "amoxapine targets CHRM1",
"source_label": "amoxapine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.542",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "amoxapine targets CHRM2",
"source_label": "amoxapine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "amoxapine targets CHRM3",
"source_label": "amoxapine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.423",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "amoxapine targets CHRM4",
"source_label": "amoxapine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.616",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "amoxapine targets CHRM5",
"source_label": "amoxapine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.211",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "amoxapine targets DRD1",
"source_label": "amoxapine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.708",
"act_comment": "DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "amoxapine targets DRD2",
"source_label": "amoxapine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "amoxapine targets DRD3",
"source_label": "amoxapine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.734",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "amoxapine targets DRD4",
"source_label": "amoxapine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.47",
"act_comment": "Displacement of [3H]-YM09151-2 from human cloned dopamine D4 receptor expressed in insect Sf9 cells after 60 mins by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "amoxapine targets HRH1",
"source_label": "amoxapine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.959",
"act_comment": "DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "amoxapine targets HTR1A",
"source_label": "amoxapine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "amoxapine targets HTR2A",
"source_label": "amoxapine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.75",
"act_comment": "Displacement of [3H]ketanserin from human recombinant 5HT2A receptor expressed in CHO cells after 60 mins by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "amoxapine targets HTR2B",
"source_label": "amoxapine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.182",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "amoxapine targets HTR2C",
"source_label": "amoxapine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "amoxapine targets HTR3A",
"source_label": "amoxapine",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT3 radioligand binding (ligand: [3H] GR-65630)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "amoxapine targets HTR6",
"source_label": "amoxapine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "amoxapine targets HTR7",
"source_label": "amoxapine",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Binding affinity towards human 5-hydroxytryptamine 7 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "amoxapine targets SLC6A2",
"source_label": "amoxapine",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.886",
"act_comment": "DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2170",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "amoxapine targets SLC6A4",
"source_label": "amoxapine",
"target_label": "SLC6A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.469",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:33613",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "amoxicillin targets HTR2A",
"source_label": "amoxicillin",
"target_label": "HTR2A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:73333",
"relation": "IDG (Drug Target)",
"target": "2166",
"properties": {
"id": "amperozide targets FAAH",
"source_label": "amperozide",
"target_label": "FAAH",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.34",
"act_comment": "Inhibition of human FAAH-mediated hydrolysis of [3H]AEA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3007",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "amfetamine targets SLC6A3",
"source_label": "amfetamine",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.936",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3007",
"relation": "IDG (Drug Target)",
"target": "134864",
"properties": {
"id": "amfetamine targets TAAR1",
"source_label": "amfetamine",
"target_label": "TAAR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.222",
"act_comment": "(S) enantiomer activation of hTAAR1 in RD-HGA16 cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:65016",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "amprenavir targets CYP3A4",
"source_label": "amprenavir",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3926765",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "amsacrine targets KCNH2",
"source_label": "amsacrine",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Inhibition of human ERG potassium channel",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3926765",
"relation": "IDG (Drug Target)",
"target": "7150",
"properties": {
"id": "amsacrine targets TOP1",
"source_label": "amsacrine",
"target_label": "TOP1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.43",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3926765",
"relation": "IDG (Drug Target)",
"target": "116447",
"properties": {
"id": "amsacrine targets TOP1MT",
"source_label": "amsacrine",
"target_label": "TOP1MT",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.43",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2182",
"relation": "IDG (Drug Target)",
"target": "5139",
"properties": {
"id": "anagrelide targets PDE3A",
"source_label": "anagrelide",
"target_label": "PDE3A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.27",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2187",
"relation": "IDG (Drug Target)",
"target": "1588",
"properties": {
"id": "anastrozole targets CYP19A1",
"source_label": "anastrozole",
"target_label": "CYP19A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.222",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:10634",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "androstenediol targets AR",
"source_label": "androstenediol",
"target_label": "AR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Binding affinity at AR",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10634",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "androstenediol targets ESR1",
"source_label": "androstenediol",
"target_label": "ESR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Binding affinity at human recombinant ERalpha",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10634",
"relation": "IDG (Drug Target)",
"target": "2100",
"properties": {
"id": "androstenediol targets ESR2",
"source_label": "androstenediol",
"target_label": "ESR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Binding affinity at human recombinant ERbeta",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10634",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "androstenediol targets SHBG",
"source_label": "androstenediol",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.17",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6128",
"relation": "IDG (Drug Target)",
"target": "1588",
"properties": {
"id": "androstenedione targets CYP19A1",
"source_label": "androstenedione",
"target_label": "CYP19A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Binding affinity for aromatase cytochrome P45019A1 by analysis of Dixon plot",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6128",
"relation": "IDG (Drug Target)",
"target": "3293",
"properties": {
"id": "androstenedione targets HSD17B3",
"source_label": "androstenedione",
"target_label": "HSD17B3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.31",
"act_comment": "Ability to inhibit the Type-3 17-beta- hydroxysteroid dehydrogenase activity transfected in human embryonic kidney (HEK)-293 cells experiment 3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6128",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "androstenedione targets SHBG",
"source_label": "androstenedione",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.46",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2202",
"relation": "IDG (Drug Target)",
"target": "3249",
"properties": {
"id": "dithranol targets HPN",
"source_label": "dithranol",
"target_label": "HPN",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "High-Throughput Screening Assay: To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleavage of the chromogenic peptide. In addition, the NINDS II library of 1040 compounds (MicroSource Discovery) was screened to identify hepsin inhibitors among established drugs and known bioactive molecules. Screens were performed in a 96-well format at a final compound concentration of 2 uM. To minimize false positives, positions 1 and 12 of each row contained DMSO/buffer controls. As a measure of reproducibility, the Z' score for this assay was 0.78 (Zhang et al., 1999 J Biomol Screen 4:67).",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2202",
"relation": "IDG (Drug Target)",
"target": "23408",
"properties": {
"id": "dithranol targets SIRT5",
"source_label": "dithranol",
"target_label": "SIRT5",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Inhibition of SIRT5 (unknown origin) using GGQSLK[succ]FGKG as substrate after 30 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6005",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "apomorphine targets ADRA1D",
"source_label": "apomorphine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.187",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6005",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "apomorphine targets ADRA2A",
"source_label": "apomorphine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6005",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "apomorphine targets ADRA2B",
"source_label": "apomorphine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6005",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "apomorphine targets ADRA2C",
"source_label": "apomorphine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6005",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "apomorphine targets DRD1",
"source_label": "apomorphine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.34",
"act_comment": "Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6005",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "apomorphine targets DRD2",
"source_label": "apomorphine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.21",
"act_comment": "Displacement of [3H]spiperone from human dopamine D2 receptor at high affinity state expressed in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6005",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "apomorphine targets DRD3",
"source_label": "apomorphine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.59",
"act_comment": "Displacement of [3H]domperidone from human cloned dopamine D3 receptor expressed in mouse CCL1-3 cells by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6005",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "apomorphine targets DRD4",
"source_label": "apomorphine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "Displacement of [3H]A369508 from human D4 receptor expressed in HEK293 cell membrane",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6005",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "apomorphine targets DRD5",
"source_label": "apomorphine",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6005",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "apomorphine targets HTR1A",
"source_label": "apomorphine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.53",
"act_comment": "Binding affinity was measured on cloned Human 5-hydroxytryptamine 1A receptor which is labeled by [3H]8-OH-DPAT",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6005",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "apomorphine targets HTR2A",
"source_label": "apomorphine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6005",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "apomorphine targets HTR2B",
"source_label": "apomorphine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6005",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "apomorphine targets HTR2C",
"source_label": "apomorphine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6005",
"relation": "IDG (Drug Target)",
"target": "4193",
"properties": {
"id": "apomorphine targets MDM2",
"source_label": "apomorphine",
"target_label": "MDM2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.71",
"act_comment": "Inhibition of biotin-labelled D-p53 binding to D-MDM2 (25 to 109 residues) (unknown origin) by FAM labeled P4 peptide based fluorescence polarization assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2216",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "apraclonidine targets ADRA2A",
"source_label": "apraclonidine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.54",
"act_comment": "Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2216",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "apraclonidine targets ADRA2B",
"source_label": "apraclonidine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.938",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2216",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "apraclonidine targets ADRA2C",
"source_label": "apraclonidine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "Compound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamster ovary (CHO) cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:135413536",
"relation": "IDG (Drug Target)",
"target": "6869",
"properties": {
"id": "aprepitant targets TACR1",
"source_label": "aprepitant",
"target_label": "TACR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.7",
"act_comment": "GRAC: human NK1 selective antagonist",
"act_source": "CHEMBL"
}
},
{
"source": "CID:135413536",
"relation": "IDG (Drug Target)",
"target": "6870",
"properties": {
"id": "aprepitant targets TACR3",
"source_label": "aprepitant",
"target_label": "TACR3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.34",
"act_comment": "Displacement of [3H]osanetant from wild type human NK3 receptor expressed in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2218",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "aprindine targets CYP2D6",
"source_label": "aprindine",
"target_label": "CYP2D6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.757",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:92722",
"relation": "IDG (Drug Target)",
"target": "2147",
"properties": {
"id": "argatroban targets F2",
"source_label": "argatroban",
"target_label": "F2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.398",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "5243",
"properties": {
"id": "aripiprazole targets ABCB1",
"source_label": "aripiprazole",
"target_label": "ABCB1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Inhibition of human ABCB1-mediated rhodamine 123 efflux in mouse L5178 cells expressing human MDR1 after 20 mins by FACS analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "aripiprazole targets ADRA1A",
"source_label": "aripiprazole",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.244",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "aripiprazole targets ADRA1B",
"source_label": "aripiprazole",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.463",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "aripiprazole targets ADRA2A",
"source_label": "aripiprazole",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.131",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "aripiprazole targets ADRA2B",
"source_label": "aripiprazole",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.991",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "aripiprazole targets ADRA2C",
"source_label": "aripiprazole",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.421",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "aripiprazole targets ADRB1",
"source_label": "aripiprazole",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.851",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "aripiprazole targets DRD1",
"source_label": "aripiprazole",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.06",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "aripiprazole targets DRD2",
"source_label": "aripiprazole",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.71",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "aripiprazole targets DRD3",
"source_label": "aripiprazole",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.53",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "aripiprazole targets DRD4",
"source_label": "aripiprazole",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.65",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "3005",
"properties": {
"id": "aripiprazole targets H1-0",
"source_label": "aripiprazole",
"target_label": "H1-0",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.55",
"act_comment": "Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, \u00ce\u00b1A1, 5-HT2C and H1 Receptors.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "aripiprazole targets HRH1",
"source_label": "aripiprazole",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.215",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "aripiprazole targets HTR1A",
"source_label": "aripiprazole",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.15",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "aripiprazole targets HTR1B",
"source_label": "aripiprazole",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "aripiprazole targets HTR1D",
"source_label": "aripiprazole",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "aripiprazole targets HTR2A",
"source_label": "aripiprazole",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "aripiprazole targets HTR2B",
"source_label": "aripiprazole",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.444",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "aripiprazole targets HTR2C",
"source_label": "aripiprazole",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.36",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "aripiprazole targets HTR3A",
"source_label": "aripiprazole",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.202",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "aripiprazole targets HTR6",
"source_label": "aripiprazole",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "aripiprazole targets HTR7",
"source_label": "aripiprazole",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.69",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "aripiprazole targets KCNH2",
"source_label": "aripiprazole",
"target_label": "KCNH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Displacement of [3H]dofetilide from human ERG",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60795",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "aripiprazole targets SLC6A4",
"source_label": "aripiprazole",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.83",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "5243",
"properties": {
"id": "astemizole targets ABCB1",
"source_label": "astemizole",
"target_label": "ABCB1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "astemizole targets ADRA1D",
"source_label": "astemizole",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.004",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "astemizole targets ADRA2C",
"source_label": "astemizole",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.545",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "astemizole targets CHRM1",
"source_label": "astemizole",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "astemizole targets CHRM2",
"source_label": "astemizole",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "astemizole targets CHRM3",
"source_label": "astemizole",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.75",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "astemizole targets CHRM4",
"source_label": "astemizole",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.587",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "astemizole targets CHRM5",
"source_label": "astemizole",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.297",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "astemizole targets DRD3",
"source_label": "astemizole",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.83",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "astemizole targets HRH1",
"source_label": "astemizole",
"target_label": "HRH1",
"act_type": "A2",
"act_relation": "=",
"act_value": "8.58",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "astemizole targets HTR1A",
"source_label": "astemizole",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.359",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "astemizole targets HTR2A",
"source_label": "astemizole",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.253",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "astemizole targets HTR2B",
"source_label": "astemizole",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.126",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "astemizole targets HTR2C",
"source_label": "astemizole",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.027",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "astemizole targets HTR3A",
"source_label": "astemizole",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.018",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT3 radioligand binding (ligand: [3H] GR-65630)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "3756",
"properties": {
"id": "astemizole targets KCNH1",
"source_label": "astemizole",
"target_label": "KCNH1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "astemizole targets KCNH2",
"source_label": "astemizole",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.046",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "astemizole targets OPRM1",
"source_label": "astemizole",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.218",
"act_comment": "DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "astemizole targets SIGMAR1",
"source_label": "astemizole",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.025",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "astemizole targets SLC6A3",
"source_label": "astemizole",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.101",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "astemizole targets SLC6A4",
"source_label": "astemizole",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.155",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "6865",
"properties": {
"id": "astemizole targets TACR2",
"source_label": "astemizole",
"target_label": "TACR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.002",
"act_comment": "DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2247",
"relation": "IDG (Drug Target)",
"target": "27346",
"properties": {
"id": "astemizole targets TMEM97",
"source_label": "astemizole",
"target_label": "TMEM97",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.02",
"act_comment": "Displacement of [3H]-DTG from the Sigma2 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:175540",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "atenolol targets ADORA3",
"source_label": "atenolol",
"target_label": "ADORA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.75",
"act_comment": "Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:175540",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "atenolol targets ADRB1",
"source_label": "atenolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:54841",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "atomoxetine targets SLC6A2",
"source_label": "atomoxetine",
"target_label": "SLC6A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.69",
"act_comment": "Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporter",
"act_source": "CHEMBL"
}
},
{
"source": "CID:54841",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "atomoxetine targets SLC6A4",
"source_label": "atomoxetine",
"target_label": "SLC6A4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter-hSERT",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60823",
"relation": "IDG (Drug Target)",
"target": "3156",
"properties": {
"id": "atorvastatin targets HMGCR",
"source_label": "atorvastatin",
"target_label": "HMGCR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:62887",
"relation": "IDG (Drug Target)",
"target": "1136",
"properties": {
"id": "atracurium targets CHRNA3",
"source_label": "atracurium",
"target_label": "CHRNA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.05",
"act_comment": "Antagonism of ACh activation of human &alpha3&beta2 or &alpha3&beta4 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:62887",
"relation": "IDG (Drug Target)",
"target": "1137",
"properties": {
"id": "atracurium targets CHRNA4",
"source_label": "atracurium",
"target_label": "CHRNA4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "Antagonism of ACh activation of human &alpha4&beta2 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:62887",
"relation": "IDG (Drug Target)",
"target": "1139",
"properties": {
"id": "atracurium targets CHRNA7",
"source_label": "atracurium",
"target_label": "CHRNA7",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.25",
"act_comment": "Antagonism of ACh activation of human &alpha7 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:174174",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "atropine targets ADRA1D",
"source_label": "atropine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.177",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:174174",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "atropine targets CHRM1",
"source_label": "atropine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.31",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:174174",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "atropine targets CHRM2",
"source_label": "atropine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.97",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:174174",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "atropine targets CHRM3",
"source_label": "atropine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:174174",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "atropine targets CHRM4",
"source_label": "atropine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.39",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:174174",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "atropine targets CHRM5",
"source_label": "atropine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.29",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:174174",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "atropine targets HTR2C",
"source_label": "atropine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.276",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2264",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "azasetron targets HTR3A",
"source_label": "azasetron",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.268",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:2267",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "azelastine targets ADRA1A",
"source_label": "azelastine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Binding affinity to human adrenergic alpha1A receptor expressed in rat intact fibroblasts",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2267",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "azelastine targets ADRA1B",
"source_label": "azelastine",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Binding affinity to human adrenergic Alpha-1B receptor expressed in rat intact fibroblasts",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2267",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "azelastine targets HRH1",
"source_label": "azelastine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.168",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2267",
"relation": "IDG (Drug Target)",
"target": "11255",
"properties": {
"id": "azelastine targets HRH3",
"source_label": "azelastine",
"target_label": "HRH3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.83",
"act_comment": "Antagonist activity at human H3 receptor expressed in CHO cells assessed as inhibition of histamine-induced GTPgamma[S] binding by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2267",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "azelastine targets HTR2B",
"source_label": "azelastine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2267",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "azelastine targets HTR2C",
"source_label": "azelastine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Displacement of [3H]mesulergine from recombinant human 5-ht2C expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2267",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "azelastine targets KCNH2",
"source_label": "azelastine",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Displacement of labeled dofetilide human ERG",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9571004",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "azimilide targets KCNH2",
"source_label": "azimilide",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Inhibitory concentration against IKr potassium channel",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2284",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "baclofen targets ADORA3",
"source_label": "baclofen",
"target_label": "ADORA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:54766",
"relation": "IDG (Drug Target)",
"target": "590",
"properties": {
"id": "bambuterol targets BCHE",
"source_label": "bambuterol",
"target_label": "BCHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:21700",
"relation": "IDG (Drug Target)",
"target": "222487",
"properties": {
"id": "beclometasone dipropionate targets ADGRG3",
"source_label": "beclometasone dipropionate",
"target_label": "ADGRG3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:21700",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "beclometasone dipropionate targets NR3C1",
"source_label": "beclometasone dipropionate",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.427",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:21700",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "beclometasone dipropionate targets NR3C2",
"source_label": "beclometasone dipropionate",
"target_label": "NR3C2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.32",
"act_comment": "Induction of nuclear translocation of human recombinant ProLabel-tagged mineralocorticoid receptor expressed in CHO-K1 cells after 3 hrs by luminescence method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:21700",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "beclometasone dipropionate targets PGR",
"source_label": "beclometasone dipropionate",
"target_label": "PGR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.55",
"act_comment": "Displacement of fluormone labelled PL Red from human recombinant progesterone receptor after 1 to 6 hrs ligand by fluorescence polarization assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6456014",
"relation": "IDG (Drug Target)",
"target": "7150",
"properties": {
"id": "belotecan targets TOP1",
"source_label": "belotecan",
"target_label": "TOP1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.561",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5362124",
"relation": "IDG (Drug Target)",
"target": "1636",
"properties": {
"id": "benazepril targets ACE",
"source_label": "benazepril",
"target_label": "ACE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:65628",
"relation": "IDG (Drug Target)",
"target": "3065",
"properties": {
"id": "bendamustine targets HDAC1",
"source_label": "bendamustine",
"target_label": "HDAC1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65628",
"relation": "IDG (Drug Target)",
"target": "83933",
"properties": {
"id": "bendamustine targets HDAC10",
"source_label": "bendamustine",
"target_label": "HDAC10",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.14",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65628",
"relation": "IDG (Drug Target)",
"target": "3066",
"properties": {
"id": "bendamustine targets HDAC2",
"source_label": "bendamustine",
"target_label": "HDAC2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65628",
"relation": "IDG (Drug Target)",
"target": "8841",
"properties": {
"id": "bendamustine targets HDAC3",
"source_label": "bendamustine",
"target_label": "HDAC3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65628",
"relation": "IDG (Drug Target)",
"target": "10013",
"properties": {
"id": "bendamustine targets HDAC6",
"source_label": "bendamustine",
"target_label": "HDAC6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65628",
"relation": "IDG (Drug Target)",
"target": "55869",
"properties": {
"id": "bendamustine targets HDAC8",
"source_label": "bendamustine",
"target_label": "HDAC8",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.97",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2315",
"relation": "IDG (Drug Target)",
"target": "6559",
"properties": {
"id": "bendroflumethiazide targets SLC12A3",
"source_label": "bendroflumethiazide",
"target_label": "SLC12A3",
"act_type": "A2",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16363",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "benperidol targets DRD2",
"source_label": "benperidol",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.57",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16363",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "benperidol targets DRD3",
"source_label": "benperidol",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.18",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16363",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "benperidol targets DRD4",
"source_label": "benperidol",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16363",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "benperidol targets HTR2A",
"source_label": "benperidol",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16363",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "benperidol targets KCNH2",
"source_label": "benperidol",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.47",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3055",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "diphenidol targets CHRM1",
"source_label": "diphenidol",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.108",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3055",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "diphenidol targets CHRM2",
"source_label": "diphenidol",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.562",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3055",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "diphenidol targets CHRM3",
"source_label": "diphenidol",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.284",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3055",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "diphenidol targets CHRM4",
"source_label": "diphenidol",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3055",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "diphenidol targets CHRM5",
"source_label": "diphenidol",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.068",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3055",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "diphenidol targets CYP2D6",
"source_label": "diphenidol",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.486",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3055",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "diphenidol targets DRD3",
"source_label": "diphenidol",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.105",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3055",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "diphenidol targets HTR2A",
"source_label": "diphenidol",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.131",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3055",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "diphenidol targets SIGMAR1",
"source_label": "diphenidol",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.967",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2333",
"relation": "IDG (Drug Target)",
"target": "4363",
"properties": {
"id": "benzbromarone targets ABCC1",
"source_label": "benzbromarone",
"target_label": "ABCC1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Inhibition of human MRP1 expressed in Spodoptera frugiperda Sf9 cells assessed as inhibition of NEM-GS-induced vanadate-sensitive ATPase activity measured by generation of inorganic phosphate by spectrophotometry in presence of glutathione",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2333",
"relation": "IDG (Drug Target)",
"target": "1645",
"properties": {
"id": "benzbromarone targets AKR1C1",
"source_label": "benzbromarone",
"target_label": "AKR1C1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.32",
"act_comment": "Inhibition of 20-alpha HSD",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2333",
"relation": "IDG (Drug Target)",
"target": "1559",
"properties": {
"id": "benzbromarone targets CYP2C9",
"source_label": "benzbromarone",
"target_label": "CYP2C9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2333",
"relation": "IDG (Drug Target)",
"target": "116085",
"properties": {
"id": "benzbromarone targets SLC22A12",
"source_label": "benzbromarone",
"target_label": "SLC22A12",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.59",
"act_comment": "Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2342",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "benzquinamide targets ADRA2B",
"source_label": "benzquinamide",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.161",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:2342",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "benzquinamide targets ADRA2C",
"source_label": "benzquinamide",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.264",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:2342",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "benzquinamide targets PTGS2",
"source_label": "benzquinamide",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.32",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2343",
"relation": "IDG (Drug Target)",
"target": "6559",
"properties": {
"id": "benzthiazide targets SLC12A3",
"source_label": "benzthiazide",
"target_label": "SLC12A3",
"act_type": "A2",
"act_relation": "=",
"act_value": "8.17",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:1201549",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "benzatropine targets ADRA1D",
"source_label": "benzatropine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.585",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1201549",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "benzatropine targets ADRA2A",
"source_label": "benzatropine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.69",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1201549",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "benzatropine targets ADRA2B",
"source_label": "benzatropine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.523",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1201549",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "benzatropine targets ADRA2C",
"source_label": "benzatropine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.244",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1201549",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "benzatropine targets CHRM1",
"source_label": "benzatropine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.636",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:1201549",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "benzatropine targets CHRM2",
"source_label": "benzatropine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.854",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:1201549",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "benzatropine targets CHRM3",
"source_label": "benzatropine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.959",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:1201549",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "benzatropine targets CHRM4",
"source_label": "benzatropine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.959",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:1201549",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "benzatropine targets CHRM5",
"source_label": "benzatropine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.553",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:1201549",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "benzatropine targets DRD3",
"source_label": "benzatropine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.654",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1201549",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "benzatropine targets HRH1",
"source_label": "benzatropine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.959",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:1201549",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "benzatropine targets HTR2A",
"source_label": "benzatropine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.157",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1201549",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "benzatropine targets HTR2B",
"source_label": "benzatropine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.896",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1201549",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "benzatropine targets HTR2C",
"source_label": "benzatropine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.495",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1201549",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "benzatropine targets SIGMAR1",
"source_label": "benzatropine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.229",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1201549",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "benzatropine targets SLC6A3",
"source_label": "benzatropine",
"target_label": "SLC6A3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.253",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2351",
"relation": "IDG (Drug Target)",
"target": "773",
"properties": {
"id": "bepridil targets CACNA1A",
"source_label": "bepridil",
"target_label": "CACNA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2351",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "bepridil targets KCNH2",
"source_label": "bepridil",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6917951",
"relation": "IDG (Drug Target)",
"target": "5733",
"properties": {
"id": "beraprost targets PTGER3",
"source_label": "beraprost",
"target_label": "PTGER3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6917951",
"relation": "IDG (Drug Target)",
"target": "5739",
"properties": {
"id": "beraprost targets PTGIR",
"source_label": "beraprost",
"target_label": "PTGIR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.37",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2366",
"relation": "IDG (Drug Target)",
"target": "11255",
"properties": {
"id": "betahistine targets HRH3",
"source_label": "betahistine",
"target_label": "HRH3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.523",
"act_comment": "[125I]Iodoproxyfan binding to H3 receptors in CHO cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9782",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "betamethasone targets NR3C1",
"source_label": "betamethasone",
"target_label": "NR3C1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.07",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2369",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "betaxolol targets ADRB1",
"source_label": "betaxolol",
"target_label": "ADRB1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2369",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "betaxolol targets ADRB2",
"source_label": "betaxolol",
"target_label": "ADRB2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:82146",
"relation": "IDG (Drug Target)",
"target": "7376",
"properties": {
"id": "bexarotene targets NR1H2",
"source_label": "bexarotene",
"target_label": "NR1H2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Partial agonist activity at recombinant human GAL4-DBD-fused LXRbeta-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:82146",
"relation": "IDG (Drug Target)",
"target": "10062",
"properties": {
"id": "bexarotene targets NR1H3",
"source_label": "bexarotene",
"target_label": "NR1H3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.71",
"act_comment": "Partial agonist activity at recombinant human GAL4-DBD-fused LXRalpha-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:82146",
"relation": "IDG (Drug Target)",
"target": "5914",
"properties": {
"id": "bexarotene targets RARA",
"source_label": "bexarotene",
"target_label": "RARA",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Selective activity towards retinoic acid receptor-alpha",
"act_source": "CHEMBL"
}
},
{
"source": "CID:82146",
"relation": "IDG (Drug Target)",
"target": "5915",
"properties": {
"id": "bexarotene targets RARB",
"source_label": "bexarotene",
"target_label": "RARB",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Selective activity towards retinoic acid receptor-beta",
"act_source": "CHEMBL"
}
},
{
"source": "CID:82146",
"relation": "IDG (Drug Target)",
"target": "5916",
"properties": {
"id": "bexarotene targets RARG",
"source_label": "bexarotene",
"target_label": "RARG",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Selective activity towards retinoic acid receptor-gamma",
"act_source": "CHEMBL"
}
},
{
"source": "CID:82146",
"relation": "IDG (Drug Target)",
"target": "6256",
"properties": {
"id": "bexarotene targets RXRA",
"source_label": "bexarotene",
"target_label": "RXRA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Inhibition of [3H]9-cis-RA binding to baculovirus expressed retinoid receptor RXR alpha",
"act_source": "CHEMBL"
}
},
{
"source": "CID:82146",
"relation": "IDG (Drug Target)",
"target": "6257",
"properties": {
"id": "bexarotene targets RXRB",
"source_label": "bexarotene",
"target_label": "RXRB",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.23",
"act_comment": "Selective activity towards retinoid X receptor-beta",
"act_source": "CHEMBL"
}
},
{
"source": "CID:82146",
"relation": "IDG (Drug Target)",
"target": "6258",
"properties": {
"id": "bexarotene targets RXRG",
"source_label": "bexarotene",
"target_label": "RXRG",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.08",
"act_comment": "Selective activity towards retinoid X receptor-gamma",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2375",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "bicalutamide targets AR",
"source_label": "bicalutamide",
"target_label": "AR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "Inhibition of human AR",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2375",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "bicalutamide targets CYP2C19",
"source_label": "bicalutamide",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2378",
"relation": "IDG (Drug Target)",
"target": "1586",
"properties": {
"id": "bifonazole targets CYP17A1",
"source_label": "bifonazole",
"target_label": "CYP17A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.25",
"act_comment": "In vitro inhibition of human Cytochrome P450 17A1 activity",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2378",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "bifonazole targets CYP3A4",
"source_label": "bifonazole",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "In vitro CYP3A4 Inhibition Assay: Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute to the elimination of ATRA by catalyzing its 4-hydroxylation in the mammalian liver and skin, including that of humans as well as swine. Applicant evaluated the potential RAMBA activity of several azoles using pig liver microsomes, a rich source of CYP activity, comprising many different CYP 450 isoforms. Therefore, this approach, while a reasonable way to assess CYP inhibitors with broad activities may or may not be the best way to discover RAMBAs with selectivity for the skin, which has a much more narrow complement of CYP expression. As understanding in this area has progressed, a more specific CYP inhibition assay can be used to provide better predictivity of activity in human skin. Nevertheless, this assay may still be used as a general predictor of overall CYP activity.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2378",
"relation": "IDG (Drug Target)",
"target": "1595",
"properties": {
"id": "bifonazole targets CYP51A1",
"source_label": "bifonazole",
"target_label": "CYP51A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2381",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "biperiden targets CHRM1",
"source_label": "biperiden",
"target_label": "CHRM1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.32",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2381",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "biperiden targets CHRM2",
"source_label": "biperiden",
"target_label": "CHRM2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2381",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "biperiden targets CHRM3",
"source_label": "biperiden",
"target_label": "CHRM3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.41",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2381",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "biperiden targets CHRM4",
"source_label": "biperiden",
"target_label": "CHRM4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.62",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2381",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "biperiden targets CHRM5",
"source_label": "biperiden",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.201",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2391",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "bisacodyl targets OPRK1",
"source_label": "bisacodyl",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.011",
"act_comment": "DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2405",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "bisoprolol targets ADRB1",
"source_label": "bisoprolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.65",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16129704",
"relation": "IDG (Drug Target)",
"target": "2147",
"properties": {
"id": "bivalirudin targets F2",
"source_label": "bivalirudin",
"target_label": "F2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:125564",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "blonanserin targets ADRA1A",
"source_label": "blonanserin",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.25",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:125564",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "blonanserin targets DRD2",
"source_label": "blonanserin",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.854",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:125564",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "blonanserin targets HTR2A",
"source_label": "blonanserin",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.092",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:125564",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "blonanserin targets SIGMAR1",
"source_label": "blonanserin",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:44112",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "bopindolol targets ADRB1",
"source_label": "bopindolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.51",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:44112",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "bopindolol targets ADRB2",
"source_label": "bopindolol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.65",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:44112",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "bopindolol targets ADRB3",
"source_label": "bopindolol",
"target_label": "ADRB3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.463",
"act_comment": "DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:44112",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "bopindolol targets HTR1A",
"source_label": "bopindolol",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.815",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:44112",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "bopindolol targets HTR2A",
"source_label": "bopindolol",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.345",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:44112",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "bopindolol targets HTR2B",
"source_label": "bopindolol",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.014",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:387447",
"relation": "IDG (Drug Target)",
"target": "1504",
"properties": {
"id": "bortezomib targets CTRB1",
"source_label": "bortezomib",
"target_label": "CTRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.49",
"act_comment": "Inhibitory activity against human Chymotrypsinogen",
"act_source": "CHEMBL"
}
},
{
"source": "CID:387447",
"relation": "IDG (Drug Target)",
"target": "1511",
"properties": {
"id": "bortezomib targets CTSG",
"source_label": "bortezomib",
"target_label": "CTSG",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "Inhibitory activity against human cathepsin G",
"act_source": "CHEMBL"
}
},
{
"source": "CID:387447",
"relation": "IDG (Drug Target)",
"target": "5662",
"properties": {
"id": "bortezomib targets PSD",
"source_label": "bortezomib",
"target_label": "PSD",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.745",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:387447",
"relation": "IDG (Drug Target)",
"target": "5682",
"properties": {
"id": "bortezomib targets PSMA1",
"source_label": "bortezomib",
"target_label": "PSMA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.208",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:387447",
"relation": "IDG (Drug Target)",
"target": "5689",
"properties": {
"id": "bortezomib targets PSMB1",
"source_label": "bortezomib",
"target_label": "PSMB1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.28",
"act_comment": "Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta1 after 30 mins by fluorogenic assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:387447",
"relation": "IDG (Drug Target)",
"target": "5699",
"properties": {
"id": "bortezomib targets PSMB10",
"source_label": "bortezomib",
"target_label": "PSMB10",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "Inhibition of 20S proteasome beta 2i (unknown origin) after 1 hr by fluorescence based assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:387447",
"relation": "IDG (Drug Target)",
"target": "5690",
"properties": {
"id": "bortezomib targets PSMB2",
"source_label": "bortezomib",
"target_label": "PSMB2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.23",
"act_comment": "Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta2 after 30 mins by fluorogenic assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:387447",
"relation": "IDG (Drug Target)",
"target": "5693",
"properties": {
"id": "bortezomib targets PSMB5",
"source_label": "bortezomib",
"target_label": "PSMB5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.26",
"act_comment": "Inhibition of 20S proteasome beta5 subunit (unknown origin) assessed as formation of reversible adduct with N-terminal threonine",
"act_source": "CHEMBL"
}
},
{
"source": "CID:387447",
"relation": "IDG (Drug Target)",
"target": "5696",
"properties": {
"id": "bortezomib targets PSMB8",
"source_label": "bortezomib",
"target_label": "PSMB8",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.09",
"act_comment": "Inhibition of chymotrypsin-like activity of LMP7 immunoproteasome by proteasome active site ELISA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:387447",
"relation": "IDG (Drug Target)",
"target": "5698",
"properties": {
"id": "bortezomib targets PSMB9",
"source_label": "bortezomib",
"target_label": "PSMB9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "Inhibition of human peripheral blood derived 20s immunoproteasome beta1 caspase-like activity using Suc-PAL-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:387447",
"relation": "IDG (Drug Target)",
"target": "5707",
"properties": {
"id": "bortezomib targets PSMD1",
"source_label": "bortezomib",
"target_label": "PSMD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.745",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:104865",
"relation": "IDG (Drug Target)",
"target": "1909",
"properties": {
"id": "bosentan targets EDNRA",
"source_label": "bosentan",
"target_label": "EDNRA",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.19",
"act_comment": "Ability to displace endothelin ([125I]ET1) from human Endothelin A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:104865",
"relation": "IDG (Drug Target)",
"target": "1910",
"properties": {
"id": "bosentan targets EDNRB",
"source_label": "bosentan",
"target_label": "EDNRB",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "Inhibitory activity against human endothelin B receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2435",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "brimonidine targets ADRA1D",
"source_label": "brimonidine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.073",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2435",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "brimonidine targets ADRA2A",
"source_label": "brimonidine",
"target_label": "ADRA2A",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.387",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2435",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "brimonidine targets ADRA2B",
"source_label": "brimonidine",
"target_label": "ADRA2B",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.26",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2435",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "brimonidine targets ADRA2C",
"source_label": "brimonidine",
"target_label": "ADRA2C",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.469",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:68844",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "brinzolamide targets CA1",
"source_label": "brinzolamide",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "Compound was evaluated for binding affinity against human carbonic anhydrase II (hCA -II)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68844",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "brinzolamide targets CA12",
"source_label": "brinzolamide",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "Inhibitory activity against catalytic domain of human carbonic anhydrase XII",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68844",
"relation": "IDG (Drug Target)",
"target": "377677",
"properties": {
"id": "brinzolamide targets CA13",
"source_label": "brinzolamide",
"target_label": "CA13",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Inhibition of human carbonic anhydrase13 preincubated for 15 mins by stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68844",
"relation": "IDG (Drug Target)",
"target": "23632",
"properties": {
"id": "brinzolamide targets CA14",
"source_label": "brinzolamide",
"target_label": "CA14",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.62",
"act_comment": "Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68844",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "brinzolamide targets CA2",
"source_label": "brinzolamide",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.9",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 2 by dansylamide (DNSA) competition assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68844",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "brinzolamide targets CA5A",
"source_label": "brinzolamide",
"target_label": "CA5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Inhibitory activity against human recombinant mitochondrial isozyme CA VA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68844",
"relation": "IDG (Drug Target)",
"target": "11238",
"properties": {
"id": "brinzolamide targets CA5B",
"source_label": "brinzolamide",
"target_label": "CA5B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "Inhibitory activity against human recombinant mitochondrial isozyme CA VB",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68844",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "brinzolamide targets CA6",
"source_label": "brinzolamide",
"target_label": "CA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.05",
"act_comment": "Inhibition of full length human recombinant CA VI",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68844",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "brinzolamide targets CA7",
"source_label": "brinzolamide",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.55",
"act_comment": "Ki value against human carbonic anhydrase VII",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68844",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "brinzolamide targets CA9",
"source_label": "brinzolamide",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.44",
"act_comment": "Inhibition of human carbonic anhydrase9 preincubated for 15 mins by stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44629987",
"relation": "IDG (Drug Target)",
"target": "7083",
"properties": {
"id": "brivudine targets TK1",
"source_label": "brivudine",
"target_label": "TK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Binding affinity constant against HSV-1 thymidine kinase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60726",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "bromfenac targets PTGS1",
"source_label": "bromfenac",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.29",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60726",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "bromfenac targets PTGS2",
"source_label": "bromfenac",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2442",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "bromhexine targets CYP2D6",
"source_label": "bromhexine",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.708",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2442",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "bromhexine targets SIGMAR1",
"source_label": "bromhexine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.602",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:31101",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "bromocriptine targets ADRA1A",
"source_label": "bromocriptine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.38",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:31101",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "bromocriptine targets ADRA1D",
"source_label": "bromocriptine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.55",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:31101",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "bromocriptine targets ADRA2A",
"source_label": "bromocriptine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:31101",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "bromocriptine targets ADRA2B",
"source_label": "bromocriptine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:31101",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "bromocriptine targets ADRA2C",
"source_label": "bromocriptine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:31101",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "bromocriptine targets DRD1",
"source_label": "bromocriptine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:31101",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "bromocriptine targets DRD2",
"source_label": "bromocriptine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:31101",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "bromocriptine targets DRD3",
"source_label": "bromocriptine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:31101",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "bromocriptine targets DRD4",
"source_label": "bromocriptine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:31101",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "bromocriptine targets DRD5",
"source_label": "bromocriptine",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:31101",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "bromocriptine targets HTR1A",
"source_label": "bromocriptine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:31101",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "bromocriptine targets HTR1B",
"source_label": "bromocriptine",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:31101",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "bromocriptine targets HTR1D",
"source_label": "bromocriptine",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:31101",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "bromocriptine targets HTR2A",
"source_label": "bromocriptine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:31101",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "bromocriptine targets HTR2B",
"source_label": "bromocriptine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:31101",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "bromocriptine targets HTR2C",
"source_label": "bromocriptine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:31101",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "bromocriptine targets HTR6",
"source_label": "bromocriptine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2444",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "bromazine targets HRH1",
"source_label": "bromazine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.886",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2446",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "bromopride targets DRD2",
"source_label": "bromopride",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2448",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "bromperidol targets ADRA1A",
"source_label": "bromperidol",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2448",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "bromperidol targets DRD1",
"source_label": "bromperidol",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2448",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "bromperidol targets DRD2",
"source_label": "bromperidol",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.43",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2448",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "bromperidol targets DRD3",
"source_label": "bromperidol",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2448",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "bromperidol targets DRD4",
"source_label": "bromperidol",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2448",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "bromperidol targets HRH1",
"source_label": "bromperidol",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.155",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2448",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "bromperidol targets SIGMAR1",
"source_label": "bromperidol",
"target_label": "SIGMAR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.02",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6834",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "brompheniramine targets HRH1",
"source_label": "brompheniramine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.218",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:6834",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "brompheniramine targets KCNH2",
"source_label": "brompheniramine",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Inhibition of human ERG",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2451",
"relation": "IDG (Drug Target)",
"target": "5724",
"properties": {
"id": "brotizolam targets PTAFR",
"source_label": "brotizolam",
"target_label": "PTAFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5281004",
"relation": "IDG (Drug Target)",
"target": "3458",
"properties": {
"id": "budesonide targets IFNG",
"source_label": "budesonide",
"target_label": "IFNG",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5281004",
"relation": "IDG (Drug Target)",
"target": "3567",
"properties": {
"id": "budesonide targets IL5",
"source_label": "budesonide",
"target_label": "IL5",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.92",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5281004",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "budesonide targets NR3C1",
"source_label": "budesonide",
"target_label": "NR3C1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "10.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5281004",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "budesonide targets NR3C2",
"source_label": "budesonide",
"target_label": "NR3C2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5281004",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "budesonide targets PGR",
"source_label": "budesonide",
"target_label": "PGR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.55",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:68778",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "budipine targets KCNH2",
"source_label": "budipine",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "Inhibition of human ERG",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2467",
"relation": "IDG (Drug Target)",
"target": "10682",
"properties": {
"id": "buflomedil targets EBP",
"source_label": "buflomedil",
"target_label": "EBP",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.22",
"act_comment": "Affinity for human EMP expressed in ERG2 deficient strain of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71733",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "bufuralol targets ADRB1",
"source_label": "bufuralol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71733",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "bufuralol targets ADRB2",
"source_label": "bufuralol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2471",
"relation": "IDG (Drug Target)",
"target": "476",
"properties": {
"id": "bumetanide targets ATP1A1",
"source_label": "bumetanide",
"target_label": "ATP1A1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2471",
"relation": "IDG (Drug Target)",
"target": "6557",
"properties": {
"id": "bumetanide targets SLC12A1",
"source_label": "bumetanide",
"target_label": "SLC12A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:39468",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "levobunolol targets ADRB1",
"source_label": "levobunolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.399",
"act_comment": "DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:39468",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "levobunolol targets ADRB2",
"source_label": "levobunolol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.263",
"act_comment": "DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:39468",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "levobunolol targets ADRB3",
"source_label": "levobunolol",
"target_label": "ADRB3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.593",
"act_comment": "DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:39468",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "levobunolol targets SIGMAR1",
"source_label": "levobunolol",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.488",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2474",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "bupivacaine targets CYP2D6",
"source_label": "bupivacaine",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.398",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2474",
"relation": "IDG (Drug Target)",
"target": "6329",
"properties": {
"id": "bupivacaine targets SCN4A",
"source_label": "bupivacaine",
"target_label": "SCN4A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2475",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "bupranolol targets ADRB1",
"source_label": "bupranolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2475",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "bupranolol targets ADRB2",
"source_label": "bupranolol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2475",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "bupranolol targets ADRB3",
"source_label": "bupranolol",
"target_label": "ADRB3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:644073",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "buprenorphine targets OPRD1",
"source_label": "buprenorphine",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.07",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:644073",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "buprenorphine targets OPRK1",
"source_label": "buprenorphine",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.01",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:644073",
"relation": "IDG (Drug Target)",
"target": "4987",
"properties": {
"id": "buprenorphine targets OPRL1",
"source_label": "buprenorphine",
"target_label": "OPRL1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.11",
"act_comment": "Displacement of [3H]-N/OFQ from human nociceptin opioid receptor transfected in CHO cells after 60 mins by beta-plate liquid scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644073",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "buprenorphine targets OPRM1",
"source_label": "buprenorphine",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.29",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:444",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "bupropion targets SLC6A3",
"source_label": "bupropion",
"target_label": "SLC6A3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:50225",
"relation": "IDG (Drug Target)",
"target": "2798",
"properties": {
"id": "buserelin targets GNRHR",
"source_label": "buserelin",
"target_label": "GNRHR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "10.52",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:50225",
"relation": "IDG (Drug Target)",
"target": "3973",
"properties": {
"id": "buserelin targets LHCGR",
"source_label": "buserelin",
"target_label": "LHCGR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.569",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2477",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "buspirone targets ADRA1A",
"source_label": "buspirone",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.435",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2477",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "buspirone targets ADRA1D",
"source_label": "buspirone",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.277",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2477",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "buspirone targets DRD2",
"source_label": "buspirone",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.68",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2477",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "buspirone targets DRD3",
"source_label": "buspirone",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.18",
"act_comment": "Inhibition of [3H]spiperone binding to Dopamine receptor D3 in bovine cortex",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2477",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "buspirone targets DRD4",
"source_label": "buspirone",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2477",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "buspirone targets HTR1A",
"source_label": "buspirone",
"target_label": "HTR1A",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.25",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2477",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "buspirone targets HTR2A",
"source_label": "buspirone",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2477",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "buspirone targets HTR2B",
"source_label": "buspirone",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2477",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "buspirone targets HTR2C",
"source_label": "buspirone",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2477",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "buspirone targets HTR7",
"source_label": "buspirone",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.08",
"act_comment": "Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2477",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "buspirone targets SIGMAR1",
"source_label": "buspirone",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.319",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2484",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "butenafine targets CYP2D6",
"source_label": "butenafine",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.523",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2484",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "butenafine targets SLC6A4",
"source_label": "butenafine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.125",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5361092",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "butorphanol targets OPRD1",
"source_label": "butorphanol",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Displacement of [3H]Naltindole from human delta opioid receptor expressed in CHO cell membrane",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5361092",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "butorphanol targets OPRK1",
"source_label": "butorphanol",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.92",
"act_comment": "Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cell membrane",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5361092",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "butorphanol targets OPRM1",
"source_label": "butorphanol",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.92",
"act_comment": "Displacement of [3H]DAMGO form human mu opioid receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:54746",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "cabergoline targets ADRA1A",
"source_label": "cabergoline",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:54746",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "cabergoline targets ADRA2A",
"source_label": "cabergoline",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:54746",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "cabergoline targets ADRA2B",
"source_label": "cabergoline",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:54746",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "cabergoline targets ADRA2C",
"source_label": "cabergoline",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:54746",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "cabergoline targets DRD1",
"source_label": "cabergoline",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:54746",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "cabergoline targets DRD2",
"source_label": "cabergoline",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:54746",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "cabergoline targets DRD3",
"source_label": "cabergoline",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:54746",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "cabergoline targets DRD4",
"source_label": "cabergoline",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:54746",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "cabergoline targets DRD5",
"source_label": "cabergoline",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:54746",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "cabergoline targets HTR1A",
"source_label": "cabergoline",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:54746",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "cabergoline targets HTR1B",
"source_label": "cabergoline",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:54746",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "cabergoline targets HTR1D",
"source_label": "cabergoline",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:54746",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "cabergoline targets HTR2A",
"source_label": "cabergoline",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:54746",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "cabergoline targets HTR2B",
"source_label": "cabergoline",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.85",
"act_comment": "Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:54746",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "cabergoline targets HTR2C",
"source_label": "cabergoline",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5288783",
"relation": "IDG (Drug Target)",
"target": "7421",
"properties": {
"id": "calcipotriene targets VDR",
"source_label": "calcipotriene",
"target_label": "VDR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.51",
"act_comment": "Binding affinity to VDR receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280453",
"relation": "IDG (Drug Target)",
"target": "2638",
"properties": {
"id": "calcitriol targets GC",
"source_label": "calcitriol",
"target_label": "GC",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.62",
"act_comment": "Binding affinity to human vitamin D binding protein",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280453",
"relation": "IDG (Drug Target)",
"target": "7421",
"properties": {
"id": "calcitriol targets VDR",
"source_label": "calcitriol",
"target_label": "VDR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2536",
"relation": "IDG (Drug Target)",
"target": "3249",
"properties": {
"id": "camostat targets HPN",
"source_label": "camostat",
"target_label": "HPN",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.54",
"act_comment": "Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Boc-QRR-AMC as substrate after 15 mins by automated fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2536",
"relation": "IDG (Drug Target)",
"target": "5644",
"properties": {
"id": "camostat targets PRSS1",
"source_label": "camostat",
"target_label": "PRSS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Concentration required to inhibit enzymatic cleavage of the chromogenic substrate (Boc-Phe-Ser-Arg-AMC) for trypsin in vitro.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2536",
"relation": "IDG (Drug Target)",
"target": "7113",
"properties": {
"id": "camostat targets TMPRSS2",
"source_label": "camostat",
"target_label": "TMPRSS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Inhibition of TMPRSS2-dependent MERS-S-mediated membrane fusion in an in vitro reporter assay.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2540",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "candesartan cilexetil targets ADORA3",
"source_label": "candesartan cilexetil",
"target_label": "ADORA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2540",
"relation": "IDG (Drug Target)",
"target": "185",
"properties": {
"id": "candesartan cilexetil targets AGTR1",
"source_label": "candesartan cilexetil",
"target_label": "AGTR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.16",
"act_comment": "Displacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:13789",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "canrenone targets NR3C2",
"source_label": "canrenone",
"target_label": "NR3C2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.523",
"act_comment": "inhibitION the aldosterone-induced MR activity",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44093",
"relation": "IDG (Drug Target)",
"target": "1636",
"properties": {
"id": "captopril targets ACE",
"source_label": "captopril",
"target_label": "ACE",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:44093",
"relation": "IDG (Drug Target)",
"target": "2147",
"properties": {
"id": "captopril targets F2",
"source_label": "captopril",
"target_label": "F2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.32",
"act_comment": "Inhibitory activity against thrombin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44093",
"relation": "IDG (Drug Target)",
"target": "4048",
"properties": {
"id": "captopril targets LTA4H",
"source_label": "captopril",
"target_label": "LTA4H",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "Inhibitory activity against Leukotriene A4 hydrolase from human leukocytes",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44093",
"relation": "IDG (Drug Target)",
"target": "5972",
"properties": {
"id": "captopril targets REN",
"source_label": "captopril",
"target_label": "REN",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.77",
"act_comment": "Antihypertensive activity against human renin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6472",
"relation": "IDG (Drug Target)",
"target": "5547",
"properties": {
"id": "caramiphen targets PRCP",
"source_label": "caramiphen",
"target_label": "PRCP",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.59",
"act_comment": "Inhibition of [3H]- (+) - pentazocine binding to PCP receptor obtained from tissue homogenate preparation of fresh whole rat brain minus cerebellum",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6472",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "caramiphen targets SIGMAR1",
"source_label": "caramiphen",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.81",
"act_comment": "Binding affinity against Sigma receptor type 1 was determined by the displacement of [3H]pentazocine radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71739",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "carazolol targets ADRB2",
"source_label": "carazolol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.94",
"act_comment": "Displacement of [3H]DHA from human beta2 adrenoceptor by liquid scintillation counter",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71739",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "carazolol targets ADRB3",
"source_label": "carazolol",
"target_label": "ADRB3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2551",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "carbachol targets CHRM1",
"source_label": "carbachol",
"target_label": "CHRM1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.523",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2551",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "carbachol targets CHRM2",
"source_label": "carbachol",
"target_label": "CHRM2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.921",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2551",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "carbachol targets CHRM3",
"source_label": "carbachol",
"target_label": "CHRM3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.699",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2551",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "carbachol targets CHRM4",
"source_label": "carbachol",
"target_label": "CHRM4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.577",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2551",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "carbachol targets CHRM5",
"source_label": "carbachol",
"target_label": "CHRM5",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.097",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:636403",
"relation": "IDG (Drug Target)",
"target": "3290",
"properties": {
"id": "carbenoxolone targets HSD11B1",
"source_label": "carbenoxolone",
"target_label": "HSD11B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.08",
"act_comment": "Ability to convert [3H]cortisol to the tritium labeled cortisone in the presence of human 11 beta hydroxysteroid dehydrogenase type 2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2562",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "pentoxyverine targets CHRM1",
"source_label": "pentoxyverine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.12",
"act_comment": "Binding affinity towards muscarinic m1 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2562",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "pentoxyverine targets CHRM2",
"source_label": "pentoxyverine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.78",
"act_comment": "Binding affinity towards muscarinic m2 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2562",
"relation": "IDG (Drug Target)",
"target": "5547",
"properties": {
"id": "pentoxyverine targets PRCP",
"source_label": "pentoxyverine",
"target_label": "PRCP",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.49",
"act_comment": "Inhibition of [3H]- (+) - pentazocine binding to PCP receptor obtained from tissue homogenate preparation of fresh whole rat brain minus cerebellum",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2562",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "pentoxyverine targets SIGMAR1",
"source_label": "pentoxyverine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.71",
"act_comment": "Binding affinity against Sigma receptor type 1 was determined by the displacement of [3H]pentazocine radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:73707428",
"relation": "IDG (Drug Target)",
"target": "552",
"properties": {
"id": "carbetocin targets AVPR1A",
"source_label": "carbetocin",
"target_label": "AVPR1A",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.39",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:73707428",
"relation": "IDG (Drug Target)",
"target": "5021",
"properties": {
"id": "carbetocin targets OXTR",
"source_label": "carbetocin",
"target_label": "OXTR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.149",
"act_comment": "oxytocin receptors expressed in COS-7 cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:2577",
"relation": "IDG (Drug Target)",
"target": "427",
"properties": {
"id": "carmofur targets ASAH1",
"source_label": "carmofur",
"target_label": "ASAH1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.68",
"act_comment": "Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for 30 mins followed by substrate addition measured after 1 hr by fluorogenic assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16129708",
"relation": "IDG (Drug Target)",
"target": "4881",
"properties": {
"id": "carperitide targets NPR1",
"source_label": "carperitide",
"target_label": "NPR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "10.0",
"act_comment": "Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2580",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "carpipramine targets DRD2",
"source_label": "carpipramine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.06",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2580",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "carpipramine targets DRD3",
"source_label": "carpipramine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.824",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2581",
"relation": "IDG (Drug Target)",
"target": "727",
"properties": {
"id": "carprofen targets C5",
"source_label": "carprofen",
"target_label": "C5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Binding affinity to human C5a assessed as dissociation constant after 1 hr by circular dichroism analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2581",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "carprofen targets PTGS2",
"source_label": "carprofen",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Inhibition of human recombinant COX2 after 5 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2583",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "carteolol targets ADRB1",
"source_label": "carteolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2583",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "carteolol targets ADRB2",
"source_label": "carteolol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "carvedilol targets ADRA1A",
"source_label": "carvedilol",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.66",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "carvedilol targets ADRA1D",
"source_label": "carvedilol",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.054",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "carvedilol targets ADRA2A",
"source_label": "carvedilol",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.398",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "carvedilol targets ADRA2B",
"source_label": "carvedilol",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.367",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "carvedilol targets ADRA2C",
"source_label": "carvedilol",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.886",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "carvedilol targets ADRB1",
"source_label": "carvedilol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "carvedilol targets ADRB2",
"source_label": "carvedilol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "carvedilol targets ADRB3",
"source_label": "carvedilol",
"target_label": "ADRB3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "carvedilol targets DRD1",
"source_label": "carvedilol",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.126",
"act_comment": "DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "carvedilol targets DRD2",
"source_label": "carvedilol",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.31",
"act_comment": "DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "carvedilol targets DRD3",
"source_label": "carvedilol",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.708",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "carvedilol targets HTR1A",
"source_label": "carvedilol",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.476",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "carvedilol targets HTR2A",
"source_label": "carvedilol",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.932",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "carvedilol targets HTR2B",
"source_label": "carvedilol",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.824",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "carvedilol targets HTR2C",
"source_label": "carvedilol",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.222",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "carvedilol targets HTR6",
"source_label": "carvedilol",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.152",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "carvedilol targets KCNH2",
"source_label": "carvedilol",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Inhibitory concentration against IKr potassium channel",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "carvedilol targets SLC6A2",
"source_label": "carvedilol",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.273",
"act_comment": "DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "carvedilol targets SLC6A3",
"source_label": "carvedilol",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.173",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2585",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "carvedilol targets SLC6A4",
"source_label": "carvedilol",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.928",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:51387307",
"relation": "IDG (Drug Target)",
"target": "156",
"properties": {
"id": "cefsulodin targets GRK2",
"source_label": "cefsulodin",
"target_label": "GRK2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "PUBCHEM_BIOASSAY: Dose Response of inhibitors of GRK2 binding with RNA aptamer, Cherry Pick 1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488855]",
"act_source": "CHEMBL"
}
},
{
"source": "CID:51387307",
"relation": "IDG (Drug Target)",
"target": "26013",
"properties": {
"id": "cefsulodin targets L3MBTL1",
"source_label": "cefsulodin",
"target_label": "L3MBTL1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.01",
"act_comment": "Inhibition of L3MBTL1 (unknown origin) by AlphaScreen assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2662",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "celecoxib targets ADRA2B",
"source_label": "celecoxib",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2662",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "celecoxib targets CA12",
"source_label": "celecoxib",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.74",
"act_comment": "Inhibitory activity against cloned human CA12",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2662",
"relation": "IDG (Drug Target)",
"target": "377677",
"properties": {
"id": "celecoxib targets CA13",
"source_label": "celecoxib",
"target_label": "CA13",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.01",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 13 after 15 mins by stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2662",
"relation": "IDG (Drug Target)",
"target": "23632",
"properties": {
"id": "celecoxib targets CA14",
"source_label": "celecoxib",
"target_label": "CA14",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 14 after 15 mins by stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2662",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "celecoxib targets CA2",
"source_label": "celecoxib",
"target_label": "CA2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.68",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2662",
"relation": "IDG (Drug Target)",
"target": "762",
"properties": {
"id": "celecoxib targets CA4",
"source_label": "celecoxib",
"target_label": "CA4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.06",
"act_comment": "Inhibitory activity against human carbonic anhydrase IV (hCAIV)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2662",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "celecoxib targets CA5A",
"source_label": "celecoxib",
"target_label": "CA5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 5a after 15 mins by stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2662",
"relation": "IDG (Drug Target)",
"target": "11238",
"properties": {
"id": "celecoxib targets CA5B",
"source_label": "celecoxib",
"target_label": "CA5B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.03",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 5b after 15 mins by stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2662",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "celecoxib targets CA6",
"source_label": "celecoxib",
"target_label": "CA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.03",
"act_comment": "Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2662",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "celecoxib targets CYP2D6",
"source_label": "celecoxib",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2662",
"relation": "IDG (Drug Target)",
"target": "10013",
"properties": {
"id": "celecoxib targets HDAC6",
"source_label": "celecoxib",
"target_label": "HDAC6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 cells using Boc-Lys-(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2662",
"relation": "IDG (Drug Target)",
"target": "1432",
"properties": {
"id": "celecoxib targets MAPK14",
"source_label": "celecoxib",
"target_label": "MAPK14",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Inhibitory concentration against p38 alpha MAP kinase calculated by CoMFA model; FlexX score=-12.4 kcal/mol",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2662",
"relation": "IDG (Drug Target)",
"target": "4513",
"properties": {
"id": "celecoxib targets COX2",
"source_label": "celecoxib",
"target_label": "COX2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.27",
"act_comment": "Inhibition of human COX2 assessed as reduction in PGF2alpha production by ELISA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2662",
"relation": "IDG (Drug Target)",
"target": "9536",
"properties": {
"id": "celecoxib targets PTGES",
"source_label": "celecoxib",
"target_label": "PTGES",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2662",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "celecoxib targets PTGS1",
"source_label": "celecoxib",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Inhibition of COX-1 in U-937 (human lymphoma) cell microsomes.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2662",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "celecoxib targets PTGS2",
"source_label": "celecoxib",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.24",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2662",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "celecoxib targets SLC6A3",
"source_label": "celecoxib",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.18",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2663",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "celiprolol targets ADRB1",
"source_label": "celiprolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2663",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "celiprolol targets ADRB2",
"source_label": "celiprolol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:7048637",
"relation": "IDG (Drug Target)",
"target": "5778",
"properties": {
"id": "cefalotin targets PTPN7",
"source_label": "cefalotin",
"target_label": "PTPN7",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:7048637",
"relation": "IDG (Drug Target)",
"target": "55867",
"properties": {
"id": "cefalotin targets SLC22A11",
"source_label": "cefalotin",
"target_label": "SLC22A11",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:7048637",
"relation": "IDG (Drug Target)",
"target": "9376",
"properties": {
"id": "cefalotin targets SLC22A8",
"source_label": "cefalotin",
"target_label": "SLC22A8",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.59",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:30699",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "cefapirin targets SIGMAR1",
"source_label": "cefapirin",
"target_label": "SIGMAR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:446156",
"relation": "IDG (Drug Target)",
"target": "3156",
"properties": {
"id": "cerivastatin targets HMGCR",
"source_label": "cerivastatin",
"target_label": "HMGCR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2678",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "cetirizine targets HRH1",
"source_label": "cetirizine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.91",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:25074887",
"relation": "IDG (Drug Target)",
"target": "2798",
"properties": {
"id": "cetrorelix targets GNRHR",
"source_label": "cetrorelix",
"target_label": "GNRHR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "GRAC: human GnRH1 selective antagonist",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2684",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "cevimeline targets CHRM1",
"source_label": "cevimeline",
"target_label": "CHRM1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.638",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2684",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "cevimeline targets CHRM3",
"source_label": "cevimeline",
"target_label": "CHRM3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.319",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2684",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "cevimeline targets CHRM5",
"source_label": "cevimeline",
"target_label": "CHRM5",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.201",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2708",
"relation": "IDG (Drug Target)",
"target": "8754",
"properties": {
"id": "chlorambucil targets ADAM9",
"source_label": "chlorambucil",
"target_label": "ADAM9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.25",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2708",
"relation": "IDG (Drug Target)",
"target": "1509",
"properties": {
"id": "chlorambucil targets CTSD",
"source_label": "chlorambucil",
"target_label": "CTSD",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.93",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2708",
"relation": "IDG (Drug Target)",
"target": "1510",
"properties": {
"id": "chlorambucil targets CTSE",
"source_label": "chlorambucil",
"target_label": "CTSE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.78",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2712",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "chlordiazepoxide targets HRH1",
"source_label": "chlordiazepoxide",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.682",
"act_comment": "DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2712",
"relation": "IDG (Drug Target)",
"target": "7201",
"properties": {
"id": "chlordiazepoxide targets TRHR",
"source_label": "chlordiazepoxide",
"target_label": "TRHR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.538",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2713",
"relation": "IDG (Drug Target)",
"target": "6580",
"properties": {
"id": "chlorhexidine targets SLC22A1",
"source_label": "chlorhexidine",
"target_label": "SLC22A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Inhibition of human OCT1-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2713",
"relation": "IDG (Drug Target)",
"target": "6582",
"properties": {
"id": "chlorhexidine targets SLC22A2",
"source_label": "chlorhexidine",
"target_label": "SLC22A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2713",
"relation": "IDG (Drug Target)",
"target": "6581",
"properties": {
"id": "chlorhexidine targets SLC22A3",
"source_label": "chlorhexidine",
"target_label": "SLC22A3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "Inhibition of human OCT3-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2713",
"relation": "IDG (Drug Target)",
"target": "55244",
"properties": {
"id": "chlorhexidine targets SLC47A1",
"source_label": "chlorhexidine",
"target_label": "SLC47A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2713",
"relation": "IDG (Drug Target)",
"target": "146802",
"properties": {
"id": "chlorhexidine targets SLC47A2",
"source_label": "chlorhexidine",
"target_label": "SLC47A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:40532410",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "chlormadinone targets NR3C1",
"source_label": "chlormadinone",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.764",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:25295",
"relation": "IDG (Drug Target)",
"target": "5747",
"properties": {
"id": "chloropyramine targets PTK2",
"source_label": "chloropyramine",
"target_label": "PTK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Binding affinity to biotinylated human FAK FAT domain by biolayer interoferometry",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2719",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "chloroquine targets SIGMAR1",
"source_label": "chloroquine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "Displacement of [3H]-pentazocin from the Sigma1 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2719",
"relation": "IDG (Drug Target)",
"target": "27346",
"properties": {
"id": "chloroquine targets TMEM97",
"source_label": "chloroquine",
"target_label": "TMEM97",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Displacement of [3H]-DTG from the Sigma2 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2725",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "chlorphenamine targets HRH1",
"source_label": "chlorphenamine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.15",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2725",
"relation": "IDG (Drug Target)",
"target": "59340",
"properties": {
"id": "chlorphenamine targets HRH4",
"source_label": "chlorphenamine",
"target_label": "HRH4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.67",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2725",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "chlorphenamine targets SLC6A4",
"source_label": "chlorphenamine",
"target_label": "SLC6A4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.818",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:10007",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "chlorphentermine targets SLC6A4",
"source_label": "chlorphentermine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.471",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:65750",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "chlorproethazine targets DRD2",
"source_label": "chlorproethazine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.979",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:65750",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "chlorproethazine targets DRD3",
"source_label": "chlorproethazine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.987",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:65750",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "chlorproethazine targets DRD4",
"source_label": "chlorproethazine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.638",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "5243",
"properties": {
"id": "chlorpromazine targets ABCB1",
"source_label": "chlorpromazine",
"target_label": "ABCB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity model",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "chlorpromazine targets ADRA1B",
"source_label": "chlorpromazine",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.092",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "chlorpromazine targets ADRA1D",
"source_label": "chlorpromazine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.708",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "chlorpromazine targets ADRA2A",
"source_label": "chlorpromazine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "chlorpromazine targets ADRA2B",
"source_label": "chlorpromazine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "chlorpromazine targets ADRA2C",
"source_label": "chlorpromazine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "316",
"properties": {
"id": "chlorpromazine targets AOX1",
"source_label": "chlorpromazine",
"target_label": "AOX1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.244",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "chlorpromazine targets CHRM1",
"source_label": "chlorpromazine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.602",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "chlorpromazine targets CHRM2",
"source_label": "chlorpromazine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.746",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "chlorpromazine targets CHRM3",
"source_label": "chlorpromazine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.251",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "chlorpromazine targets CHRM4",
"source_label": "chlorpromazine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.398",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "chlorpromazine targets CHRM5",
"source_label": "chlorpromazine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.377",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "chlorpromazine targets DRD1",
"source_label": "chlorpromazine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.19",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "chlorpromazine targets DRD2",
"source_label": "chlorpromazine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.15",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "chlorpromazine targets DRD3",
"source_label": "chlorpromazine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.54",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "chlorpromazine targets DRD4",
"source_label": "chlorpromazine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.69",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "chlorpromazine targets DRD5",
"source_label": "chlorpromazine",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.93",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "chlorpromazine targets HRH1",
"source_label": "chlorpromazine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "chlorpromazine targets HRH2",
"source_label": "chlorpromazine",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.759",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "59340",
"properties": {
"id": "chlorpromazine targets HRH4",
"source_label": "chlorpromazine",
"target_label": "HRH4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.87",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "chlorpromazine targets HTR1A",
"source_label": "chlorpromazine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Compound was evaluated for the binding affinity against [3H]8-OH-DPAT-labeled 5-hydroxytryptamine 1A receptor sites in cloned CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "chlorpromazine targets HTR1D",
"source_label": "chlorpromazine",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.345",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "chlorpromazine targets HTR1E",
"source_label": "chlorpromazine",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.463",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "chlorpromazine targets HTR2A",
"source_label": "chlorpromazine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "chlorpromazine targets HTR2B",
"source_label": "chlorpromazine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.28",
"act_comment": "Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "chlorpromazine targets HTR2C",
"source_label": "chlorpromazine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "chlorpromazine targets HTR3A",
"source_label": "chlorpromazine",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "chlorpromazine targets HTR5A",
"source_label": "chlorpromazine",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.928",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "chlorpromazine targets HTR6",
"source_label": "chlorpromazine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.44",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "chlorpromazine targets HTR7",
"source_label": "chlorpromazine",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.41",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "chlorpromazine targets SIGMAR1",
"source_label": "chlorpromazine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.724",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "chlorpromazine targets SLC6A2",
"source_label": "chlorpromazine",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.721",
"act_comment": "DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2726",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "chlorpromazine targets SLC6A4",
"source_label": "chlorpromazine",
"target_label": "SLC6A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Binding affinity to SERT (unknown origin) by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:667467",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "chlorprothixene targets DRD1",
"source_label": "chlorprothixene",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.74",
"act_comment": "Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:667467",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "chlorprothixene targets DRD2",
"source_label": "chlorprothixene",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.53",
"act_comment": "Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:667467",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "chlorprothixene targets DRD3",
"source_label": "chlorprothixene",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.34",
"act_comment": "Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:667467",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "chlorprothixene targets DRD5",
"source_label": "chlorprothixene",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:667467",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "chlorprothixene targets HRH1",
"source_label": "chlorprothixene",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.43",
"act_comment": "Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:667467",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "chlorprothixene targets HTR6",
"source_label": "chlorprothixene",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "Binding affinity towards human 5-hydroxytryptamine 6 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2732",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "chlortalidone targets CA1",
"source_label": "chlortalidone",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2732",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "chlortalidone targets CA12",
"source_label": "chlortalidone",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.35",
"act_comment": "Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2732",
"relation": "IDG (Drug Target)",
"target": "762",
"properties": {
"id": "chlortalidone targets CA4",
"source_label": "chlortalidone",
"target_label": "CA4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.71",
"act_comment": "Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2732",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "chlortalidone targets CA5A",
"source_label": "chlortalidone",
"target_label": "CA5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2732",
"relation": "IDG (Drug Target)",
"target": "11238",
"properties": {
"id": "chlortalidone targets CA5B",
"source_label": "chlortalidone",
"target_label": "CA5B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2732",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "chlortalidone targets CA7",
"source_label": "chlortalidone",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.55",
"act_comment": "Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2732",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "chlortalidone targets CA9",
"source_label": "chlortalidone",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.64",
"act_comment": "Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9064",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "cianidanol targets CA7",
"source_label": "cianidanol",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Inhibition of human carbonic anhydrase 7 after 15 mins by stopped flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311044",
"relation": "IDG (Drug Target)",
"target": "5733",
"properties": {
"id": "cicaprost targets PTGER3",
"source_label": "cicaprost",
"target_label": "PTGER3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5311044",
"relation": "IDG (Drug Target)",
"target": "5734",
"properties": {
"id": "cicaprost targets PTGER4",
"source_label": "cicaprost",
"target_label": "PTGER4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5311044",
"relation": "IDG (Drug Target)",
"target": "5739",
"properties": {
"id": "cicaprost targets PTGIR",
"source_label": "cicaprost",
"target_label": "PTGIR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6918155",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "ciclesonide targets NR3C1",
"source_label": "ciclesonide",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.43",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2749",
"relation": "IDG (Drug Target)",
"target": "142",
"properties": {
"id": "ciclopirox targets PARP1",
"source_label": "ciclopirox",
"target_label": "PARP1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:146294",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "cicloprolol targets ADRB1",
"source_label": "cicloprolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:146294",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "cicloprolol targets ADRB2",
"source_label": "cicloprolol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6435415",
"relation": "IDG (Drug Target)",
"target": "1800",
"properties": {
"id": "cilastatin targets DPEP1",
"source_label": "cilastatin",
"target_label": "DPEP1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.959",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:56330",
"relation": "IDG (Drug Target)",
"target": "1636",
"properties": {
"id": "cilazapril targets ACE",
"source_label": "cilazapril",
"target_label": "ACE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2754",
"relation": "IDG (Drug Target)",
"target": "5139",
"properties": {
"id": "cilostazol targets PDE3A",
"source_label": "cilostazol",
"target_label": "PDE3A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2754",
"relation": "IDG (Drug Target)",
"target": "5140",
"properties": {
"id": "cilostazol targets PDE3B",
"source_label": "cilostazol",
"target_label": "PDE3B",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2756",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "cimetidine targets HRH2",
"source_label": "cimetidine",
"target_label": "HRH2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:156419",
"relation": "IDG (Drug Target)",
"target": "846",
"properties": {
"id": "cinacalcet targets CASR",
"source_label": "cinacalcet",
"target_label": "CASR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Positive allosteric modulation of calcium sensing receptor by cell based assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:156419",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "cinacalcet targets CYP2D6",
"source_label": "cinacalcet",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Inhibition Assay: Incubations were conducted in 96 well microtiter plates based on a method described by BD Biosciences. To the first well in each row, a NADPH regenerating system and test compound was added. In the second well and all remaining wells, NADPH regenerating system and acetonitrile (final concentration of 2%) was added. The final assay concentration of the NADPH regenerating system was 8.2 uM NADP+, 0.41 mM glucose-6-phosphate, 0.41 mM magnesium chloride hexahydrate and 0.4 U/ml glucose-6-phosphate dehydrogenase and 0.01 mg/mL control insect cell membrane protein. The test compound solution was serially diluted 1:3 through the eighth wells.The final concentration of the test compounds were in the range 100 uM to 45.7 nM in the eight rows. Wells 9 and 10 contained no test compound (only NADPH regenerating system and enzyme/substrate mix) and wells 11 and 12 were used as controls for background fluorescence (enzyme and substrate were added after the reaction was te",
"act_source": "CHEMBL"
}
},
{
"source": "CID:156419",
"relation": "IDG (Drug Target)",
"target": "2741",
"properties": {
"id": "cinacalcet targets GLRA1",
"source_label": "cinacalcet",
"target_label": "GLRA1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.49",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1547484",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "cinnarizine targets ADRA1D",
"source_label": "cinnarizine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.242",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1547484",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "cinnarizine targets ADRA2A",
"source_label": "cinnarizine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.777",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1547484",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "cinnarizine targets ADRA2C",
"source_label": "cinnarizine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.022",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1547484",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "cinnarizine targets CHRM1",
"source_label": "cinnarizine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.218",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1547484",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "cinnarizine targets CHRM3",
"source_label": "cinnarizine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.79",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1547484",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "cinnarizine targets CHRM4",
"source_label": "cinnarizine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.292",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1547484",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "cinnarizine targets CHRM5",
"source_label": "cinnarizine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.264",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1547484",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "cinnarizine targets DRD2",
"source_label": "cinnarizine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.587",
"act_comment": "DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1547484",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "cinnarizine targets DRD3",
"source_label": "cinnarizine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.066",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1547484",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "cinnarizine targets HRH1",
"source_label": "cinnarizine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.064",
"act_comment": "DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1547484",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "cinnarizine targets HTR1A",
"source_label": "cinnarizine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.208",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1547484",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "cinnarizine targets HTR2A",
"source_label": "cinnarizine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.987",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1547484",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "cinnarizine targets HTR2B",
"source_label": "cinnarizine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.333",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1547484",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "cinnarizine targets OPRM1",
"source_label": "cinnarizine",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.035",
"act_comment": "DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1547484",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "cinnarizine targets SIGMAR1",
"source_label": "cinnarizine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1547484",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "cinnarizine targets SLC6A4",
"source_label": "cinnarizine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.237",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2763",
"relation": "IDG (Drug Target)",
"target": "5465",
"properties": {
"id": "ciprofibrate targets PPARA",
"source_label": "ciprofibrate",
"target_label": "PPARA",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Transactivation of GAL4-fused PPARalpha LBD expressed in HepG2 cells after 20 hrs by luminescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311047",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "cisapride targets ADRA1D",
"source_label": "cisapride",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.31",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5311047",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "cisapride targets ADRA2A",
"source_label": "cisapride",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.177",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5311047",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "cisapride targets ADRA2B",
"source_label": "cisapride",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.281",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5311047",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "cisapride targets ADRA2C",
"source_label": "cisapride",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.947",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5311047",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "cisapride targets CYP2D6",
"source_label": "cisapride",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.155",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5311047",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "cisapride targets CYP3A4",
"source_label": "cisapride",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.523",
"act_comment": "DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5311047",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "cisapride targets DRD2",
"source_label": "cisapride",
"target_label": "DRD2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Binding affinity to dopamine receptor D2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311047",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "cisapride targets DRD3",
"source_label": "cisapride",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.31",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5311047",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "cisapride targets HTR1A",
"source_label": "cisapride",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Binding affinity to human serotonin 5-HT1A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311047",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "cisapride targets HTR2A",
"source_label": "cisapride",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.96",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311047",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "cisapride targets HTR2B",
"source_label": "cisapride",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311047",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "cisapride targets HTR2C",
"source_label": "cisapride",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.396",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5311047",
"relation": "IDG (Drug Target)",
"target": "3360",
"properties": {
"id": "cisapride targets HTR4",
"source_label": "cisapride",
"target_label": "HTR4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.54",
"act_comment": "Binding affinity towards Serotonin 5-hydroxytryptamine 4 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311047",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "cisapride targets KCNH2",
"source_label": "cisapride",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.19",
"act_comment": "Inhibition of human ERG in MCF7 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311047",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "cisapride targets SIGMAR1",
"source_label": "cisapride",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.379",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5311047",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "cisapride targets SLC6A4",
"source_label": "cisapride",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.69",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2771",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "citalopram targets ADRA1D",
"source_label": "citalopram",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.148",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2771",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "citalopram targets HRH1",
"source_label": "citalopram",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.456",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2771",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "citalopram targets HTR2C",
"source_label": "citalopram",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2771",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "citalopram targets SIGMAR1",
"source_label": "citalopram",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.777",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2771",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "citalopram targets SLC6A4",
"source_label": "citalopram",
"target_label": "SLC6A4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.935",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2780",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "clebopride targets ACHE",
"source_label": "clebopride",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Inhibition of AChE",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2780",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "clebopride targets DRD2",
"source_label": "clebopride",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Displacement of [3H]-spiperone [0.5 nM (Kd=0.2-0.45 nM)] from human recombinant dopamine receptor D2S expressed in CHO cells at 0.5 nM concentration",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2780",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "clebopride targets DRD3",
"source_label": "clebopride",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.98",
"act_comment": "In vitro binding affinity on D3 receptor is inhibition of binding of [125I]- NCQ 298 to Sf9 cells infected with recombinant baculovirus",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2780",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "clebopride targets DRD4",
"source_label": "clebopride",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.49",
"act_comment": "Ability to displace [3H]spiperone [0.5 nM (Kd=0.1-0.45 nM)] from human recombinant dopamine receptor D4 expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2780",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "clebopride targets KCNH2",
"source_label": "clebopride",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Inhibition of human ERG",
"act_source": "CHEMBL"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "clemastine targets ADRA1D",
"source_label": "clemastine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.824",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "clemastine targets ADRA2A",
"source_label": "clemastine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.161",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "clemastine targets ADRA2B",
"source_label": "clemastine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.848",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "clemastine targets ADRA2C",
"source_label": "clemastine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.854",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "clemastine targets CHRM1",
"source_label": "clemastine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "clemastine targets CHRM2",
"source_label": "clemastine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.703",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "clemastine targets CHRM3",
"source_label": "clemastine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.084",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "clemastine targets CHRM4",
"source_label": "clemastine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.558",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "clemastine targets CHRM5",
"source_label": "clemastine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "clemastine targets CYP2C19",
"source_label": "clemastine",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.222",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "clemastine targets DRD1",
"source_label": "clemastine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.115",
"act_comment": "DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "clemastine targets DRD2",
"source_label": "clemastine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.347",
"act_comment": "DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "clemastine targets DRD3",
"source_label": "clemastine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.604",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "clemastine targets HRH1",
"source_label": "clemastine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.585",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "clemastine targets HRH2",
"source_label": "clemastine",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.439",
"act_comment": "DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "clemastine targets HTR2A",
"source_label": "clemastine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.036",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "clemastine targets HTR2B",
"source_label": "clemastine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.638",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "clemastine targets HTR2C",
"source_label": "clemastine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.284",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "clemastine targets HTR6",
"source_label": "clemastine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.444",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "clemastine targets KCNH2",
"source_label": "clemastine",
"target_label": "KCNH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.921",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "clemastine targets SIGMAR1",
"source_label": "clemastine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.854",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "clemastine targets SLC6A3",
"source_label": "clemastine",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.269",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26987",
"relation": "IDG (Drug Target)",
"target": "27346",
"properties": {
"id": "clemastine targets TMEM97",
"source_label": "clemastine",
"target_label": "TMEM97",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "Displacement of [3H]-DTG from the Sigma2 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2782",
"relation": "IDG (Drug Target)",
"target": "59340",
"properties": {
"id": "clemizole targets HRH4",
"source_label": "clemizole",
"target_label": "HRH4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.396",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2783",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "clenbuterol targets ADRB1",
"source_label": "clenbuterol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.161",
"act_comment": "DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2783",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "clenbuterol targets ADRB2",
"source_label": "clenbuterol",
"target_label": "ADRB2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "Binding affinity to beta-2 adrenergic receptor (unknown origin) at 1 to 10000 nM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2784",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "clidinium targets CHRM3",
"source_label": "clidinium",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:25419",
"relation": "IDG (Drug Target)",
"target": "63910",
"properties": {
"id": "clodronic acid targets SLC17A9",
"source_label": "clodronic acid",
"target_label": "SLC17A9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.81",
"act_comment": "Using a quantitative transport assay system involving proteoliposomes containing only expressed and purified protein.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:119182",
"relation": "IDG (Drug Target)",
"target": "6240",
"properties": {
"id": "clofarabine targets RRM1",
"source_label": "clofarabine",
"target_label": "RRM1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "Inhibition of K562 cell growth",
"act_source": "IUPHAR"
}
},
{
"source": "CID:119182",
"relation": "IDG (Drug Target)",
"target": "6241",
"properties": {
"id": "clofarabine targets RRM2",
"source_label": "clofarabine",
"target_label": "RRM2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "Inhibition of growth of K562 cells",
"act_source": "IUPHAR"
}
},
{
"source": "CID:1548953",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "clomifene targets ADRA2A",
"source_label": "clomifene",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.455",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1548953",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "clomifene targets ADRA2B",
"source_label": "clomifene",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.142",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1548953",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "clomifene targets ADRA2C",
"source_label": "clomifene",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.668",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1548953",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "clomifene targets CHRM1",
"source_label": "clomifene",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.407",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1548953",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "clomifene targets CHRM3",
"source_label": "clomifene",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.358",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1548953",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "clomifene targets CHRM4",
"source_label": "clomifene",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.638",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1548953",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "clomifene targets DRD3",
"source_label": "clomifene",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.349",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1548953",
"relation": "IDG (Drug Target)",
"target": "10682",
"properties": {
"id": "clomifene targets EBP",
"source_label": "clomifene",
"target_label": "EBP",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "Affinity for human EMP expressed in ERG2 deficient strain of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1548953",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "clomifene targets ESR1",
"source_label": "clomifene",
"target_label": "ESR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.886",
"act_comment": "DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1548953",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "clomifene targets HTR2A",
"source_label": "clomifene",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.025",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1548953",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "clomifene targets HTR2B",
"source_label": "clomifene",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.062",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1548953",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "clomifene targets HTR2C",
"source_label": "clomifene",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.177",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1548953",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "clomifene targets KCNH2",
"source_label": "clomifene",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.745",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:1548953",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "clomifene targets PTGS1",
"source_label": "clomifene",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.461",
"act_comment": "DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1548953",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "clomifene targets SIGMAR1",
"source_label": "clomifene",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1548953",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "clomifene targets SLC6A2",
"source_label": "clomifene",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.068",
"act_comment": "DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1548953",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "clomifene targets SLC6A3",
"source_label": "clomifene",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.206",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1548953",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "clomifene targets SLC6A4",
"source_label": "clomifene",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "clomipramine targets ADRA1A",
"source_label": "clomipramine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.495",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "clomipramine targets ADRA1D",
"source_label": "clomipramine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.398",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "clomipramine targets ADRA2A",
"source_label": "clomipramine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "clomipramine targets ADRA2B",
"source_label": "clomipramine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.337",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "clomipramine targets ADRA2C",
"source_label": "clomipramine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.688",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "316",
"properties": {
"id": "clomipramine targets AOX1",
"source_label": "clomipramine",
"target_label": "AOX1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.319",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "clomipramine targets CHRM1",
"source_label": "clomipramine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.658",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "clomipramine targets CHRM2",
"source_label": "clomipramine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.066",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "clomipramine targets CHRM3",
"source_label": "clomipramine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.444",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "clomipramine targets CHRM4",
"source_label": "clomipramine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.886",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "clomipramine targets CHRM5",
"source_label": "clomipramine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "clomipramine targets DRD1",
"source_label": "clomipramine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "clomipramine targets DRD2",
"source_label": "clomipramine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.95",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "clomipramine targets DRD3",
"source_label": "clomipramine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.412",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "clomipramine targets HRH1",
"source_label": "clomipramine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.007",
"act_comment": "DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "clomipramine targets HTR2A",
"source_label": "clomipramine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.45",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "clomipramine targets HTR2B",
"source_label": "clomipramine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.818",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "clomipramine targets HTR2C",
"source_label": "clomipramine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.19",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "clomipramine targets HTR6",
"source_label": "clomipramine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.95",
"act_comment": "Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1.5 hrs by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "clomipramine targets SIGMAR1",
"source_label": "clomipramine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.243",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "clomipramine targets SLC6A2",
"source_label": "clomipramine",
"target_label": "SLC6A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2801",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "clomipramine targets SLC6A4",
"source_label": "clomipramine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.703",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2803",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "clonidine targets ADRA1B",
"source_label": "clonidine",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2803",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "clonidine targets ADRA1D",
"source_label": "clonidine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2803",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "clonidine targets ADRA2A",
"source_label": "clonidine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.42",
"act_comment": "Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2803",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "clonidine targets ADRA2B",
"source_label": "clonidine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2803",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "clonidine targets ADRA2C",
"source_label": "clonidine",
"target_label": "ADRA2C",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2803",
"relation": "IDG (Drug Target)",
"target": "11188",
"properties": {
"id": "clonidine targets NISCH",
"source_label": "clonidine",
"target_label": "NISCH",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "Displacement of [3H]-clonidine from bovine imidazoline receptor I-1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60606",
"relation": "IDG (Drug Target)",
"target": "1555",
"properties": {
"id": "clopidogrel targets CYP2B6",
"source_label": "clopidogrel",
"target_label": "CYP2B6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60606",
"relation": "IDG (Drug Target)",
"target": "64805",
"properties": {
"id": "clopidogrel targets P2RY12",
"source_label": "clopidogrel",
"target_label": "P2RY12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60606",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "clopidogrel targets SLC6A4",
"source_label": "clopidogrel",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.524",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:16351",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "clotiapine targets DRD2",
"source_label": "clotiapine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.31",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2812",
"relation": "IDG (Drug Target)",
"target": "1586",
"properties": {
"id": "clotrimazole targets CYP17A1",
"source_label": "clotrimazole",
"target_label": "CYP17A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.089",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2812",
"relation": "IDG (Drug Target)",
"target": "1588",
"properties": {
"id": "clotrimazole targets CYP19A1",
"source_label": "clotrimazole",
"target_label": "CYP19A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.74",
"act_comment": "Inhibition of human placental microsome CYP19",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2812",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "clotrimazole targets CYP2C19",
"source_label": "clotrimazole",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2812",
"relation": "IDG (Drug Target)",
"target": "1559",
"properties": {
"id": "clotrimazole targets CYP2C9",
"source_label": "clotrimazole",
"target_label": "CYP2C9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2812",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "clotrimazole targets CYP3A4",
"source_label": "clotrimazole",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.699",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2812",
"relation": "IDG (Drug Target)",
"target": "1595",
"properties": {
"id": "clotrimazole targets CYP51A1",
"source_label": "clotrimazole",
"target_label": "CYP51A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2812",
"relation": "IDG (Drug Target)",
"target": "1582",
"properties": {
"id": "clotrimazole targets CYP8B1",
"source_label": "clotrimazole",
"target_label": "CYP8B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Inhibition of CYP8B1 in human liver microsomes using D7-7alpha-hydroxy-4-cholesten-3-one as substrate preincubated for 20 mins followed by substrate addition in presence of NADPH by UPLC-ESI-MS/MS analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2812",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "clotrimazole targets DRD3",
"source_label": "clotrimazole",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.046",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2812",
"relation": "IDG (Drug Target)",
"target": "3783",
"properties": {
"id": "clotrimazole targets KCNN4",
"source_label": "clotrimazole",
"target_label": "KCNN4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2812",
"relation": "IDG (Drug Target)",
"target": "9970",
"properties": {
"id": "clotrimazole targets NR1I3",
"source_label": "clotrimazole",
"target_label": "NR1I3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2812",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "clotrimazole targets OPRM1",
"source_label": "clotrimazole",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.136",
"act_comment": "DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2812",
"relation": "IDG (Drug Target)",
"target": "6916",
"properties": {
"id": "clotrimazole targets TBXAS1",
"source_label": "clotrimazole",
"target_label": "TBXAS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.854",
"act_comment": "DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "clozapine targets ADORA3",
"source_label": "clozapine",
"target_label": "ADORA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.81",
"act_comment": "Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "clozapine targets ADRA1A",
"source_label": "clozapine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "clozapine targets ADRA1B",
"source_label": "clozapine",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.98",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "clozapine targets ADRA1D",
"source_label": "clozapine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "clozapine targets ADRA2A",
"source_label": "clozapine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.154",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "clozapine targets ADRA2B",
"source_label": "clozapine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "clozapine targets ADRA2C",
"source_label": "clozapine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.54",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "clozapine targets CHRM1",
"source_label": "clozapine",
"target_label": "CHRM1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.181",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "clozapine targets CHRM2",
"source_label": "clozapine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "clozapine targets CHRM3",
"source_label": "clozapine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.591",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "clozapine targets CHRM4",
"source_label": "clozapine",
"target_label": "CHRM4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.222",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "clozapine targets CHRM5",
"source_label": "clozapine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.792",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "clozapine targets DRD1",
"source_label": "clozapine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "clozapine targets DRD2",
"source_label": "clozapine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.86",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "clozapine targets DRD3",
"source_label": "clozapine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "clozapine targets DRD4",
"source_label": "clozapine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "clozapine targets DRD5",
"source_label": "clozapine",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.594",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "3005",
"properties": {
"id": "clozapine targets H1-0",
"source_label": "clozapine",
"target_label": "H1-0",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, \u00ce\u00b1A1, 5-HT2C and H1 Receptors.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "clozapine targets HRH1",
"source_label": "clozapine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "clozapine targets HRH2",
"source_label": "clozapine",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.815",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "59340",
"properties": {
"id": "clozapine targets HRH4",
"source_label": "clozapine",
"target_label": "HRH4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.23",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "clozapine targets HTR1A",
"source_label": "clozapine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "Binding affinity to 5-HT1A receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "clozapine targets HTR1B",
"source_label": "clozapine",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "clozapine targets HTR1D",
"source_label": "clozapine",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "clozapine targets HTR1E",
"source_label": "clozapine",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "clozapine targets HTR1F",
"source_label": "clozapine",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "clozapine targets HTR2A",
"source_label": "clozapine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "clozapine targets HTR2B",
"source_label": "clozapine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.26",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "clozapine targets HTR2C",
"source_label": "clozapine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "clozapine targets HTR3A",
"source_label": "clozapine",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.28",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "clozapine targets HTR5A",
"source_label": "clozapine",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding affinity towards human 5-hydroxytryptamine 5A receptor was evaluated using [3H]-5-CT as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "clozapine targets HTR6",
"source_label": "clozapine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.95",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "clozapine targets HTR7",
"source_label": "clozapine",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.78",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398737",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "clozapine targets KCNH2",
"source_label": "clozapine",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:446220",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "cocaine targets SLC6A3",
"source_label": "cocaine",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "Binding affinity towards dopamine transporter using [3H]WIN-35428 as radioligand from rat caudate putamen tissue (high affinity)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:446220",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "cocaine targets SLC6A4",
"source_label": "cocaine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284371",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "codeine targets OPRM1",
"source_label": "codeine",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Displacement of [3H]diprenorphine from recombinant mu opioid receptor expressed in C6 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:444029",
"relation": "IDG (Drug Target)",
"target": "107",
"properties": {
"id": "colforsin daropate targets ADCY1",
"source_label": "colforsin daropate",
"target_label": "ADCY1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.39",
"act_comment": "Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:444029",
"relation": "IDG (Drug Target)",
"target": "114",
"properties": {
"id": "colforsin daropate targets ADCY8",
"source_label": "colforsin daropate",
"target_label": "ADCY8",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.03",
"act_comment": "Agonist activity at recombinant human AC8 expressed in human HEK293 cells assessed as fold increase in cAMP level by LANCE Ultra cAMP Detection kit method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:151171",
"relation": "IDG (Drug Target)",
"target": "552",
"properties": {
"id": "conivaptan targets AVPR1A",
"source_label": "conivaptan",
"target_label": "AVPR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.37",
"act_comment": "Displacement [3H]Arg human recombinant Vasopressin V1a receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:151171",
"relation": "IDG (Drug Target)",
"target": "554",
"properties": {
"id": "conivaptan targets AVPR2",
"source_label": "conivaptan",
"target_label": "AVPR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.44",
"act_comment": "Displacement [3H]Arg human recombinant Vasopressin V2 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5745",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "cortisone acetate targets NR3C1",
"source_label": "cortisone acetate",
"target_label": "NR3C1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5745",
"relation": "IDG (Drug Target)",
"target": "866",
"properties": {
"id": "cortisone acetate targets SERPINA6",
"source_label": "cortisone acetate",
"target_label": "SERPINA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5745",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "cortisone acetate targets SHBG",
"source_label": "cortisone acetate",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.43",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:323",
"relation": "IDG (Drug Target)",
"target": "23632",
"properties": {
"id": "coumarin targets CA14",
"source_label": "coumarin",
"target_label": "CA14",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.32",
"act_comment": "Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:62865",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "cyamemazine targets CHRM1",
"source_label": "cyamemazine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.886",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:62865",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "cyamemazine targets CHRM2",
"source_label": "cyamemazine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.377",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:62865",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "cyamemazine targets CHRM3",
"source_label": "cyamemazine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.495",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:62865",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "cyamemazine targets CHRM4",
"source_label": "cyamemazine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.921",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:62865",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "cyamemazine targets CHRM5",
"source_label": "cyamemazine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.456",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:62865",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "cyamemazine targets DRD1",
"source_label": "cyamemazine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.42",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:62865",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "cyamemazine targets DRD2",
"source_label": "cyamemazine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.237",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:62865",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "cyamemazine targets DRD3",
"source_label": "cyamemazine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.602",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:62865",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "cyamemazine targets HTR1A",
"source_label": "cyamemazine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:62865",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "cyamemazine targets HTR2A",
"source_label": "cyamemazine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:62865",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "cyamemazine targets HTR2C",
"source_label": "cyamemazine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:62865",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "cyamemazine targets HTR7",
"source_label": "cyamemazine",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6726",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "cyclizine targets ADRA1D",
"source_label": "cyclizine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.224",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6726",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "cyclizine targets ADRA2A",
"source_label": "cyclizine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.235",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6726",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "cyclizine targets CHRM1",
"source_label": "cyclizine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.788",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6726",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "cyclizine targets CHRM2",
"source_label": "cyclizine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.385",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6726",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "cyclizine targets CHRM3",
"source_label": "cyclizine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.799",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6726",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "cyclizine targets CHRM4",
"source_label": "cyclizine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.924",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6726",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "cyclizine targets CHRM5",
"source_label": "cyclizine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.342",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6726",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "cyclizine targets HRH1",
"source_label": "cyclizine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.353",
"act_comment": "DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6726",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "cyclizine targets HTR2A",
"source_label": "cyclizine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.194",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6726",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "cyclizine targets HTR2B",
"source_label": "cyclizine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.623",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6726",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "cyclizine targets HTR2C",
"source_label": "cyclizine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.272",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6726",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "cyclizine targets SLC6A3",
"source_label": "cyclizine",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.218",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2895",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "cyclobenzaprine targets CHRM1",
"source_label": "cyclobenzaprine",
"target_label": "CHRM1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.95",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2895",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "cyclobenzaprine targets HRH1",
"source_label": "cyclobenzaprine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.829",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2895",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "cyclobenzaprine targets HTR2A",
"source_label": "cyclobenzaprine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.541",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2895",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "cyclobenzaprine targets HTR2B",
"source_label": "cyclobenzaprine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.812",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2895",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "cyclobenzaprine targets HTR2C",
"source_label": "cyclobenzaprine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.244",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2895",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "cyclobenzaprine targets HTR6",
"source_label": "cyclobenzaprine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.839",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2895",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "cyclobenzaprine targets HTR7",
"source_label": "cyclobenzaprine",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.821",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2895",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "cyclobenzaprine targets RET",
"source_label": "cyclobenzaprine",
"target_label": "RET",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2895",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "cyclobenzaprine targets SLC6A2",
"source_label": "cyclobenzaprine",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.444",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2895",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "cyclobenzaprine targets SLC6A4",
"source_label": "cyclobenzaprine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.967",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2898",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "cyclofenil targets ESR1",
"source_label": "cyclofenil",
"target_label": "ESR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.58",
"act_comment": "Selective estrogen receptor down-regulator activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as induction of ERalpha degradation by luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9049",
"relation": "IDG (Drug Target)",
"target": "1719",
"properties": {
"id": "cycloguanil targets DHFR",
"source_label": "cycloguanil",
"target_label": "DHFR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.25",
"act_comment": "Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284373",
"relation": "IDG (Drug Target)",
"target": "5243",
"properties": {
"id": "ciclosporin targets ABCB1",
"source_label": "ciclosporin",
"target_label": "ABCB1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.301",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284373",
"relation": "IDG (Drug Target)",
"target": "8647",
"properties": {
"id": "ciclosporin targets ABCB11",
"source_label": "ciclosporin",
"target_label": "ABCB11",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284373",
"relation": "IDG (Drug Target)",
"target": "1723",
"properties": {
"id": "ciclosporin targets DHODH",
"source_label": "ciclosporin",
"target_label": "DHODH",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.699",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284373",
"relation": "IDG (Drug Target)",
"target": "2280",
"properties": {
"id": "ciclosporin targets FKBP1A",
"source_label": "ciclosporin",
"target_label": "FKBP1A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284373",
"relation": "IDG (Drug Target)",
"target": "2281",
"properties": {
"id": "ciclosporin targets FKBP1B",
"source_label": "ciclosporin",
"target_label": "FKBP1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "The compound was tested for inhibition of Peptidyl-propyl isomerase (PPIase).",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284373",
"relation": "IDG (Drug Target)",
"target": "2288",
"properties": {
"id": "ciclosporin targets FKBP4",
"source_label": "ciclosporin",
"target_label": "FKBP4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "50% inhibitory concentration of competitive binding against hCyp-18 PPIase activity using uncoupled assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284373",
"relation": "IDG (Drug Target)",
"target": "2357",
"properties": {
"id": "ciclosporin targets FPR1",
"source_label": "ciclosporin",
"target_label": "FPR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5284373",
"relation": "IDG (Drug Target)",
"target": "5478",
"properties": {
"id": "ciclosporin targets PPIA",
"source_label": "ciclosporin",
"target_label": "PPIA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.046",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284373",
"relation": "IDG (Drug Target)",
"target": "5479",
"properties": {
"id": "ciclosporin targets PPIB",
"source_label": "ciclosporin",
"target_label": "PPIB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.01",
"act_comment": "Binding affinity to human Cyclophilin B",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284373",
"relation": "IDG (Drug Target)",
"target": "5481",
"properties": {
"id": "ciclosporin targets PPID",
"source_label": "ciclosporin",
"target_label": "PPID",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.15",
"act_comment": "Inhibition of fluorescein labeled cyclosporin binding to Cyp40 by fluorescence polarization competition assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284373",
"relation": "IDG (Drug Target)",
"target": "5530",
"properties": {
"id": "ciclosporin targets PPP3CA",
"source_label": "ciclosporin",
"target_label": "PPP3CA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "Binding affinity to protein phosphatase, calcineurin (CN) was determined",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284373",
"relation": "IDG (Drug Target)",
"target": "6554",
"properties": {
"id": "ciclosporin targets SLC10A1",
"source_label": "ciclosporin",
"target_label": "SLC10A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5284373",
"relation": "IDG (Drug Target)",
"target": "10599",
"properties": {
"id": "ciclosporin targets SLCO1B1",
"source_label": "ciclosporin",
"target_label": "SLCO1B1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.29",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5284373",
"relation": "IDG (Drug Target)",
"target": "28234",
"properties": {
"id": "ciclosporin targets SLCO1B3",
"source_label": "ciclosporin",
"target_label": "SLCO1B3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "cyproheptadine targets ADRA1A",
"source_label": "cyproheptadine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "cyproheptadine targets ADRA1B",
"source_label": "cyproheptadine",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "cyproheptadine targets ADRA1D",
"source_label": "cyproheptadine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "cyproheptadine targets ADRA2A",
"source_label": "cyproheptadine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.975",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "cyproheptadine targets ADRA2B",
"source_label": "cyproheptadine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "cyproheptadine targets ADRA2C",
"source_label": "cyproheptadine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.733",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "cyproheptadine targets CHRM1",
"source_label": "cyproheptadine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "cyproheptadine targets CHRM2",
"source_label": "cyproheptadine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "cyproheptadine targets CHRM3",
"source_label": "cyproheptadine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "cyproheptadine targets CHRM4",
"source_label": "cyproheptadine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.66",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "cyproheptadine targets CHRM5",
"source_label": "cyproheptadine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.559",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "cyproheptadine targets DRD1",
"source_label": "cyproheptadine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.932",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "cyproheptadine targets DRD2",
"source_label": "cyproheptadine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.951",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "cyproheptadine targets DRD3",
"source_label": "cyproheptadine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.097",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "cyproheptadine targets HRH1",
"source_label": "cyproheptadine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.222",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "cyproheptadine targets HRH2",
"source_label": "cyproheptadine",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.71",
"act_comment": "DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "59340",
"properties": {
"id": "cyproheptadine targets HRH4",
"source_label": "cyproheptadine",
"target_label": "HRH4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.185",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "cyproheptadine targets HTR1A",
"source_label": "cyproheptadine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.229",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "cyproheptadine targets HTR2A",
"source_label": "cyproheptadine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.419",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "cyproheptadine targets HTR2B",
"source_label": "cyproheptadine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.812",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "cyproheptadine targets HTR2C",
"source_label": "cyproheptadine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.652",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "cyproheptadine targets HTR6",
"source_label": "cyproheptadine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "cyproheptadine targets HTR7",
"source_label": "cyproheptadine",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2913",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "cyproheptadine targets SLC6A2",
"source_label": "cyproheptadine",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Binding affinity towards Norepinephrine transporter using [3H]nisoxitine as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9880",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "cyproterone acetate targets AR",
"source_label": "cyproterone acetate",
"target_label": "AR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.432",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9880",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "cyproterone acetate targets NR3C1",
"source_label": "cyproterone acetate",
"target_label": "NR3C1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9880",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "cyproterone acetate targets OPRM1",
"source_label": "cyproterone acetate",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.053",
"act_comment": "DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:9880",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "cyproterone acetate targets PGR",
"source_label": "cyproterone acetate",
"target_label": "PGR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.678",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6253",
"relation": "IDG (Drug Target)",
"target": "55",
"properties": {
"id": "cytarabine targets ACP3",
"source_label": "cytarabine",
"target_label": "ACP3",
"act_type": "GI50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6253",
"relation": "IDG (Drug Target)",
"target": "4193",
"properties": {
"id": "cytarabine targets MDM2",
"source_label": "cytarabine",
"target_label": "MDM2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Inhibition of MDM2 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:135398738",
"relation": "IDG (Drug Target)",
"target": "4318",
"properties": {
"id": "dacarbazine targets MMP9",
"source_label": "dacarbazine",
"target_label": "MMP9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.255",
"act_comment": "DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:135565674",
"relation": "IDG (Drug Target)",
"target": "2147",
"properties": {
"id": "dabigatran etexilate targets F2",
"source_label": "dabigatran etexilate",
"target_label": "F2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.35",
"act_comment": "Binding affinity to human thrombin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:135565674",
"relation": "IDG (Drug Target)",
"target": "3249",
"properties": {
"id": "dabigatran etexilate targets HPN",
"source_label": "dabigatran etexilate",
"target_label": "HPN",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.08",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5702031",
"relation": "IDG (Drug Target)",
"target": "1559",
"properties": {
"id": "danazol targets CYP2C9",
"source_label": "danazol",
"target_label": "CYP2C9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.523",
"act_comment": "DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5702031",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "danazol targets SHBG",
"source_label": "danazol",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6914273",
"relation": "IDG (Drug Target)",
"target": "6261",
"properties": {
"id": "dantrolene targets RYR1",
"source_label": "dantrolene",
"target_label": "RYR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.757",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3033538",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "dapiprazole targets ADRA1D",
"source_label": "dapiprazole",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.388",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3033538",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "dapiprazole targets ADRA2B",
"source_label": "dapiprazole",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.279",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3033538",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "dapiprazole targets HTR2A",
"source_label": "dapiprazole",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.762",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3033538",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "dapiprazole targets HTR2B",
"source_label": "dapiprazole",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.173",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3033538",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "dapiprazole targets HTR2C",
"source_label": "dapiprazole",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.485",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2955",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "dapsone targets HTR6",
"source_label": "dapsone",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2955",
"relation": "IDG (Drug Target)",
"target": "4353",
"properties": {
"id": "dapsone targets MPO",
"source_label": "dapsone",
"target_label": "MPO",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Inhibition of MPO (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:444031",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "darifenacin targets ADRB1",
"source_label": "darifenacin",
"target_label": "ADRB1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:444031",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "darifenacin targets ADRB2",
"source_label": "darifenacin",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.21",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:444031",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "darifenacin targets CHRM1",
"source_label": "darifenacin",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "GRAC: human M1 antagonist",
"act_source": "CHEMBL"
}
},
{
"source": "CID:444031",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "darifenacin targets CHRM2",
"source_label": "darifenacin",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "GRAC: human M2 antagonist",
"act_source": "CHEMBL"
}
},
{
"source": "CID:444031",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "darifenacin targets CHRM3",
"source_label": "darifenacin",
"target_label": "CHRM3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.52",
"act_comment": "GRAC: human M3 probe",
"act_source": "CHEMBL"
}
},
{
"source": "CID:444031",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "darifenacin targets CHRM4",
"source_label": "darifenacin",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "GRAC: human M4 antagonist",
"act_source": "CHEMBL"
}
},
{
"source": "CID:444031",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "darifenacin targets CHRM5",
"source_label": "darifenacin",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.64",
"act_comment": "Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M5",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "dasatinib targets ABL1",
"source_label": "dasatinib",
"target_label": "ABL1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "27",
"properties": {
"id": "dasatinib targets ABL2",
"source_label": "dasatinib",
"target_label": "ABL2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.77",
"act_comment": "Binding constant for ABL2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "90",
"properties": {
"id": "dasatinib targets ACVR1",
"source_label": "dasatinib",
"target_label": "ACVR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Binding constant for ACVR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "91",
"properties": {
"id": "dasatinib targets ACVR1B",
"source_label": "dasatinib",
"target_label": "ACVR1B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Binding constant for ACVR1B kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "92",
"properties": {
"id": "dasatinib targets ACVR2A",
"source_label": "dasatinib",
"target_label": "ACVR2A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Binding constant for ACVR2A kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "93",
"properties": {
"id": "dasatinib targets ACVR2B",
"source_label": "dasatinib",
"target_label": "ACVR2B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Binding constant for ACVR2B kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "94",
"properties": {
"id": "dasatinib targets ACVRL1",
"source_label": "dasatinib",
"target_label": "ACVRL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.34",
"act_comment": "Binding constant for ACVRL1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "613",
"properties": {
"id": "dasatinib targets BCR",
"source_label": "dasatinib",
"target_label": "BCR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
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"id": "dasatinib targets BLK",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
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"id": "dasatinib targets BMPR1B",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
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"id": "dasatinib targets BMX",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "673",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "56997",
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"id": "dasatinib targets COQ8A",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
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"id": "dasatinib targets CSF1R",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
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"id": "dasatinib targets EPHA4",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
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"id": "dasatinib targets EPHA5",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
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"id": "dasatinib targets EPHA8",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "2048",
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"id": "dasatinib targets EPHB2",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "2049",
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"id": "dasatinib targets EPHB3",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "2050",
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"id": "dasatinib targets EPHB4",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "2051",
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"id": "dasatinib targets EPHB6",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "2065",
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"id": "dasatinib targets ERBB3",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "2066",
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"id": "dasatinib targets ERBB4",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "2268",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "2444",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "2534",
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"id": "dasatinib targets FYN",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "2580",
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"id": "dasatinib targets GAK",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
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"id": "dasatinib targets HCK",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "3702",
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"id": "dasatinib targets ITK",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
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"id": "dasatinib targets JAK2",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "3718",
"properties": {
"id": "dasatinib targets JAK3",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "dasatinib targets KIT",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "3932",
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"id": "dasatinib targets LCK",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "3984",
"properties": {
"id": "dasatinib targets LIMK1",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "3985",
"properties": {
"id": "dasatinib targets LIMK2",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "4067",
"properties": {
"id": "dasatinib targets LYN",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "5604",
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"id": "dasatinib targets MAP2K1",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "5607",
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"id": "dasatinib targets MAP2K5",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "80122",
"properties": {
"id": "dasatinib targets MAP3K19",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "10746",
"properties": {
"id": "dasatinib targets MAP3K2",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "4215",
"properties": {
"id": "dasatinib targets MAP3K3",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "4216",
"properties": {
"id": "dasatinib targets MAP3K4",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "11184",
"properties": {
"id": "dasatinib targets MAP4K1",
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"act_relation": "=",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "8491",
"properties": {
"id": "dasatinib targets MAP4K3",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "11183",
"properties": {
"id": "dasatinib targets MAP4K5",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "5600",
"properties": {
"id": "dasatinib targets MAPK11",
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"act_relation": "=",
"act_value": "6.39",
"act_comment": "Binding constant for full-length p38-beta",
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}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "1432",
"properties": {
"id": "dasatinib targets MAPK14",
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"act_relation": "=",
"act_value": "7.57",
"act_comment": "Binding constant for full-length p38-alpha",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "9261",
"properties": {
"id": "dasatinib targets MAPKAPK2",
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"act_type": "Kd",
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"act_value": "6.27",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "50488",
"properties": {
"id": "dasatinib targets MINK1",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "Binding constant for MINK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "4638",
"properties": {
"id": "dasatinib targets MYLK",
"source_label": "dasatinib",
"target_label": "MYLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.14",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "4661",
"properties": {
"id": "dasatinib targets MYT1",
"source_label": "dasatinib",
"target_label": "MYT1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "Binding affinity to human full-length His-tagged Myt1 kinase expressed in HEK293 cells by TR-FRET based binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "79858",
"properties": {
"id": "dasatinib targets NEK11",
"source_label": "dasatinib",
"target_label": "NEK11",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Binding constant for NEK11 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "51701",
"properties": {
"id": "dasatinib targets NLK",
"source_label": "dasatinib",
"target_label": "NLK",
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"act_relation": "=",
"act_value": "6.59",
"act_comment": "Binding constant for full-length NLK",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "10298",
"properties": {
"id": "dasatinib targets PAK4",
"source_label": "dasatinib",
"target_label": "PAK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "5156",
"properties": {
"id": "dasatinib targets PDGFRA",
"source_label": "dasatinib",
"target_label": "PDGFRA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.33",
"act_comment": "Binding constant for PDGFRA kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "dasatinib targets PDGFRB",
"source_label": "dasatinib",
"target_label": "PDGFRB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.2",
"act_comment": "Binding constant for PDGFRB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "9088",
"properties": {
"id": "dasatinib targets PKMYT1",
"source_label": "dasatinib",
"target_label": "PKMYT1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Binding constant for PKMYT1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "5585",
"properties": {
"id": "dasatinib targets PKN1",
"source_label": "dasatinib",
"target_label": "PKN1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.45",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "5588",
"properties": {
"id": "dasatinib targets PRKCQ",
"source_label": "dasatinib",
"target_label": "PRKCQ",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "5753",
"properties": {
"id": "dasatinib targets PTK6",
"source_label": "dasatinib",
"target_label": "PTK6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.11",
"act_comment": "Binding constant for PTK6 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "5894",
"properties": {
"id": "dasatinib targets RAF1",
"source_label": "dasatinib",
"target_label": "RAF1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Binding constant for RAF1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "dasatinib targets RET",
"source_label": "dasatinib",
"target_label": "RET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "Binding constant for RET(M918T) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "dasatinib targets RIPK2",
"source_label": "dasatinib",
"target_label": "RIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.51",
"act_comment": "Binding constant for RIPK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "150094",
"properties": {
"id": "dasatinib targets SIK1",
"source_label": "dasatinib",
"target_label": "SIK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.41",
"act_comment": "Binding constant for SNF1LK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "23235",
"properties": {
"id": "dasatinib targets SIK2",
"source_label": "dasatinib",
"target_label": "SIK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.19",
"act_comment": "Binding constant for full-length SNF1LK2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "23387",
"properties": {
"id": "dasatinib targets SIK3",
"source_label": "dasatinib",
"target_label": "SIK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.55",
"act_comment": "Binding constant for QSK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "9748",
"properties": {
"id": "dasatinib targets SLK",
"source_label": "dasatinib",
"target_label": "SLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Binding constant for SLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "6714",
"properties": {
"id": "dasatinib targets SRC",
"source_label": "dasatinib",
"target_label": "SRC",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.68",
"act_comment": "Binding constant for SRC kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "6725",
"properties": {
"id": "dasatinib targets SRMS",
"source_label": "dasatinib",
"target_label": "SRMS",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Binding constant for SRMS kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "140901",
"properties": {
"id": "dasatinib targets STK35",
"source_label": "dasatinib",
"target_label": "STK35",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Binding constant for STK35 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "27148",
"properties": {
"id": "dasatinib targets STK36",
"source_label": "dasatinib",
"target_label": "STK36",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Binding constant for STK36 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "7006",
"properties": {
"id": "dasatinib targets TEC",
"source_label": "dasatinib",
"target_label": "TEC",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Binding constant for TEC kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "7016",
"properties": {
"id": "dasatinib targets TESK1",
"source_label": "dasatinib",
"target_label": "TESK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.48",
"act_comment": "Binding constant for TESK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "7046",
"properties": {
"id": "dasatinib targets TGFBR1",
"source_label": "dasatinib",
"target_label": "TGFBR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Binding constant for TGFBR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "8711",
"properties": {
"id": "dasatinib targets TNK1",
"source_label": "dasatinib",
"target_label": "TNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "10188",
"properties": {
"id": "dasatinib targets TNK2",
"source_label": "dasatinib",
"target_label": "TNK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.25",
"act_comment": "Binding constant for TNK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "51086",
"properties": {
"id": "dasatinib targets TNNI3K",
"source_label": "dasatinib",
"target_label": "TNNI3K",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Binding constant for full-length TNNI3K",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "7294",
"properties": {
"id": "dasatinib targets TXK",
"source_label": "dasatinib",
"target_label": "TXK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.68",
"act_comment": "Binding constant for TXK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "7297",
"properties": {
"id": "dasatinib targets TYK2",
"source_label": "dasatinib",
"target_label": "TYK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Binding constant for TYK2(JH2domain-pseudokinase) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "494551",
"properties": {
"id": "dasatinib targets WEE2",
"source_label": "dasatinib",
"target_label": "WEE2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Binding constant for WEE2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "7525",
"properties": {
"id": "dasatinib targets YES1",
"source_label": "dasatinib",
"target_label": "YES1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.52",
"act_comment": "Binding constant for YES kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3062316",
"relation": "IDG (Drug Target)",
"target": "51776",
"properties": {
"id": "dasatinib targets MAP3K20",
"source_label": "dasatinib",
"target_label": "MAP3K20",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.35",
"act_comment": "Binding constant for ZAK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2968",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "decamethonium targets CHRM2",
"source_label": "decamethonium",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.602",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2968",
"relation": "IDG (Drug Target)",
"target": "11255",
"properties": {
"id": "decamethonium targets HRH3",
"source_label": "decamethonium",
"target_label": "HRH3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Inhibition of histamine H3 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:451668",
"relation": "IDG (Drug Target)",
"target": "1786",
"properties": {
"id": "decitabine targets DNMT1",
"source_label": "decitabine",
"target_label": "DNMT1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5881",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "prasterone targets SHBG",
"source_label": "prasterone",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.84",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5362116",
"relation": "IDG (Drug Target)",
"target": "1636",
"properties": {
"id": "delapril targets ACE",
"source_label": "delapril",
"target_label": "ACE",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.97",
"act_comment": "ACE inhibition in human coronary artery tissue",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:10050129",
"relation": "IDG (Drug Target)",
"target": "2100",
"properties": {
"id": "demeclocycline targets ESR2",
"source_label": "demeclocycline",
"target_label": "ESR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.21",
"act_comment": "PUBCHEM_BIOASSAY: Estrogen Receptor-beta Coactivator Binding Inhibitors ELISA Secondary Assay. (Class of assay: confirmatory) [Related pubchem assays: 633 (Primary screen preceding this ELISA dose response confirmation assay.), 733 (Primary dose response assay preceding this ELISA dose response confirmation assay.)]",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2995",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "desipramine targets ADRA1A",
"source_label": "desipramine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2995",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "desipramine targets CHRM1",
"source_label": "desipramine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.76",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2995",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "desipramine targets CHRM2",
"source_label": "desipramine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.27",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2995",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "desipramine targets CHRM3",
"source_label": "desipramine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2995",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "desipramine targets CHRM4",
"source_label": "desipramine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2995",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "desipramine targets CHRM5",
"source_label": "desipramine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.84",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2995",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "desipramine targets HRH1",
"source_label": "desipramine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.12",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2995",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "desipramine targets HTR2A",
"source_label": "desipramine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.796",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2995",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "desipramine targets HTR2B",
"source_label": "desipramine",
"target_label": "HTR2B",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2995",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "desipramine targets HTR2C",
"source_label": "desipramine",
"target_label": "HTR2C",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2995",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "desipramine targets SLC6A2",
"source_label": "desipramine",
"target_label": "SLC6A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.081",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2995",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "desipramine targets SLC6A3",
"source_label": "desipramine",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.31",
"act_comment": "In vitro competitive binding versus [N-methyl-3H]WIN-35428 in murine kidney cells transfected with cDNA for human dopamine transporter (DAT)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2995",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "desipramine targets SLC6A4",
"source_label": "desipramine",
"target_label": "SLC6A4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.755",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:124087",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "desloratadine targets ADRA2B",
"source_label": "desloratadine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.009",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:124087",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "desloratadine targets CHRM1",
"source_label": "desloratadine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.74",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:124087",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "desloratadine targets CHRM2",
"source_label": "desloratadine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:124087",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "desloratadine targets CHRM3",
"source_label": "desloratadine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.49",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:124087",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "desloratadine targets CHRM4",
"source_label": "desloratadine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:124087",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "desloratadine targets CHRM5",
"source_label": "desloratadine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:124087",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "desloratadine targets DRD3",
"source_label": "desloratadine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.189",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:124087",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "desloratadine targets HRH1",
"source_label": "desloratadine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:124087",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "desloratadine targets HTR2A",
"source_label": "desloratadine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.025",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:124087",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "desloratadine targets HTR2B",
"source_label": "desloratadine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.553",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:124087",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "desloratadine targets HTR2C",
"source_label": "desloratadine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:124087",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "desloratadine targets SLC6A4",
"source_label": "desloratadine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.914",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2997",
"relation": "IDG (Drug Target)",
"target": "9568",
"properties": {
"id": "nordazepam targets GABBR2",
"source_label": "nordazepam",
"target_label": "GABBR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.027",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5311065",
"relation": "IDG (Drug Target)",
"target": "552",
"properties": {
"id": "desmopressin targets AVPR1A",
"source_label": "desmopressin",
"target_label": "AVPR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.42",
"act_comment": "Binding affinity against human vasopressin V1a receptor was determined by using plasma membranes from CHO cells stably transfected with VP/OT receptors",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311065",
"relation": "IDG (Drug Target)",
"target": "553",
"properties": {
"id": "desmopressin targets AVPR1B",
"source_label": "desmopressin",
"target_label": "AVPR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.43",
"act_comment": "Binding affinity against human vasopressin V1b receptor was determined by using plasma membranes from CHO cells stably transfected with VP/OT receptors",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311065",
"relation": "IDG (Drug Target)",
"target": "554",
"properties": {
"id": "desmopressin targets AVPR2",
"source_label": "desmopressin",
"target_label": "AVPR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "Binding affinity against human vasopressin V2 receptor was determined by using plasma membranes from CHO cells stably transfected with VP/OT receptors",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311065",
"relation": "IDG (Drug Target)",
"target": "5021",
"properties": {
"id": "desmopressin targets OXTR",
"source_label": "desmopressin",
"target_label": "OXTR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:40973",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "desogestrel targets SHBG",
"source_label": "desogestrel",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311067",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "desoximetasone targets NR3C1",
"source_label": "desoximetasone",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.932",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6166",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "desoxycortone targets NR3C1",
"source_label": "desoxycortone",
"target_label": "NR3C1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6166",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "desoxycortone targets NR3C2",
"source_label": "desoxycortone",
"target_label": "NR3C2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "11.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6166",
"relation": "IDG (Drug Target)",
"target": "866",
"properties": {
"id": "desoxycortone targets SERPINA6",
"source_label": "desoxycortone",
"target_label": "SERPINA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.65",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6166",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "desoxycortone targets SHBG",
"source_label": "desoxycortone",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.38",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11876263",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "desoxycorticosterone pivalate targets NR3C2",
"source_label": "desoxycorticosterone pivalate",
"target_label": "NR3C2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "11.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:236702",
"relation": "IDG (Drug Target)",
"target": "3565",
"properties": {
"id": "dexamethasone targets IL4",
"source_label": "dexamethasone",
"target_label": "IL4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.33",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:236702",
"relation": "IDG (Drug Target)",
"target": "3567",
"properties": {
"id": "dexamethasone targets IL5",
"source_label": "dexamethasone",
"target_label": "IL5",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.456",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:236702",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "dexamethasone targets NR3C1",
"source_label": "dexamethasone",
"target_label": "NR3C1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.88",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:236702",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "dexamethasone targets NR3C2",
"source_label": "dexamethasone",
"target_label": "NR3C2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:236702",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "dexamethasone targets PGR",
"source_label": "dexamethasone",
"target_label": "PGR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "Displacement of [3H]-methyltrienolone from human progesterone receptor expressed in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:63044",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "dexamethasone palmitate targets NR3C1",
"source_label": "dexamethasone palmitate",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.26",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:63044",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "dexamethasone palmitate targets NR3C2",
"source_label": "dexamethasone palmitate",
"target_label": "NR3C2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.48",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:63044",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "dexamethasone palmitate targets PGR",
"source_label": "dexamethasone palmitate",
"target_label": "PGR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:63047",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "dexamethasone valerate targets NR3C1",
"source_label": "dexamethasone valerate",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.26",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:63047",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "dexamethasone valerate targets NR3C2",
"source_label": "dexamethasone valerate",
"target_label": "NR3C2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.48",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:63047",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "dexamethasone valerate targets PGR",
"source_label": "dexamethasone valerate",
"target_label": "PGR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:30843",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "dexetimide targets CHRM2",
"source_label": "dexetimide",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:66265",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "dexfenfluramine targets ADRA1A",
"source_label": "dexfenfluramine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:66265",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "dexfenfluramine targets ADRA1B",
"source_label": "dexfenfluramine",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.848",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:66265",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "dexfenfluramine targets ADRA2A",
"source_label": "dexfenfluramine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.275",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:66265",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "dexfenfluramine targets ADRA2B",
"source_label": "dexfenfluramine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:66265",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "dexfenfluramine targets ADRA2C",
"source_label": "dexfenfluramine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.706",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:66265",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "dexfenfluramine targets ADRB1",
"source_label": "dexfenfluramine",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.002",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:66265",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "dexfenfluramine targets HTR1A",
"source_label": "dexfenfluramine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.08",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:66265",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "dexfenfluramine targets SIGMAR1",
"source_label": "dexfenfluramine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.664",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:66265",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "dexfenfluramine targets SLC6A4",
"source_label": "dexfenfluramine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.176",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:667550",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "dexketoprofen targets PTGS1",
"source_label": "dexketoprofen",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.72",
"act_comment": "Concentration required for 50% inhibition against Prostaglandin G/H synthase 1 from human",
"act_source": "CHEMBL"
}
},
{
"source": "CID:667550",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "dexketoprofen targets PTGS2",
"source_label": "dexketoprofen",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.57",
"act_comment": "Concentration required for 50% inhibition against Prostaglandin G/H synthase 2 from human",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65937",
"relation": "IDG (Drug Target)",
"target": "886",
"properties": {
"id": "dexloxiglumide targets CCKAR",
"source_label": "dexloxiglumide",
"target_label": "CCKAR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.886",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5311068",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "dexmedetomidine targets ADRA1D",
"source_label": "dexmedetomidine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.82",
"act_comment": "In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311068",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "dexmedetomidine targets ADRA2A",
"source_label": "dexmedetomidine",
"target_label": "ADRA2A",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.82",
"act_comment": "Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311068",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "dexmedetomidine targets ADRA2B",
"source_label": "dexmedetomidine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5311068",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "dexmedetomidine targets ADRA2C",
"source_label": "dexmedetomidine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:154101",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "dexmethylphenidate targets SLC6A3",
"source_label": "dexmethylphenidate",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "Displacement of [3H]WIN-35,428 from human DAT expressed in mouse N2A cells after 15 mins by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918097",
"relation": "IDG (Drug Target)",
"target": "5243",
"properties": {
"id": "dexniguldipine targets ABCB1",
"source_label": "dexniguldipine",
"target_label": "ABCB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.432",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6918097",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "dexniguldipine targets ADRA1A",
"source_label": "dexniguldipine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.0",
"act_comment": "GRAC: human a1A selective antagonist",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918097",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "dexniguldipine targets ADRA1B",
"source_label": "dexniguldipine",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.25",
"act_comment": "Ability to displace [3H]prazosin from cloned human Alpha-1B adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918097",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "dexniguldipine targets ADRA1D",
"source_label": "dexniguldipine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918097",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "dexniguldipine targets ADRA2A",
"source_label": "dexniguldipine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918097",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "dexniguldipine targets ADRA2B",
"source_label": "dexniguldipine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.18",
"act_comment": "Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918097",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "dexniguldipine targets ADRA2C",
"source_label": "dexniguldipine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Ability to displace [3H]rauwolscine from cloned human Alpha-2C adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5826",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "dexamfetamine targets SLC6A2",
"source_label": "dexamfetamine",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5826",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "dexamfetamine targets SLC6A3",
"source_label": "dexamfetamine",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5826",
"relation": "IDG (Drug Target)",
"target": "134864",
"properties": {
"id": "dexamfetamine targets TAAR1",
"source_label": "dexamfetamine",
"target_label": "TAAR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.87",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5360696",
"relation": "IDG (Drug Target)",
"target": "2905",
"properties": {
"id": "dextromethorphan targets GRIN2C",
"source_label": "dextromethorphan",
"target_label": "GRIN2C",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Measured vs. exogenously expressed zeta1/epsilon3 (GRIN1/GRIN2C) subunits, at pH 6.9",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5360696",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "dextromethorphan targets SIGMAR1",
"source_label": "dextromethorphan",
"target_label": "SIGMAR1",
"act_type": "D2",
"act_relation": "=",
"act_value": "6.458",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5360696",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "dextromethorphan targets SLC6A4",
"source_label": "dextromethorphan",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.842",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3033053",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "dezocine targets OPRM1",
"source_label": "dezocine",
"target_label": "OPRM1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "Agonist activity at human cloned mu opioid receptor by [35S]GTPgammaS binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:26248",
"relation": "IDG (Drug Target)",
"target": "27163",
"properties": {
"id": "diacerein targets NAAA",
"source_label": "diacerein",
"target_label": "NAAA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "Time dependent inhibition of recombinant human NAAA expressed in HEK293 cells by liquid scintillation counting method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3016",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "diazepam targets ADORA3",
"source_label": "diazepam",
"target_label": "ADORA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3016",
"relation": "IDG (Drug Target)",
"target": "2558",
"properties": {
"id": "diazepam targets GABRA5",
"source_label": "diazepam",
"target_label": "GABRA5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.64",
"act_comment": "Binding affinity to GABAA alpha-5-beta-2-gamma-2 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2206",
"relation": "IDG (Drug Target)",
"target": "93100",
"properties": {
"id": "phenazone targets NAPRT",
"source_label": "phenazone",
"target_label": "NAPRT",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "Inhibition of NAPRT (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3038",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "dichlorphenamide targets CA1",
"source_label": "dichlorphenamide",
"target_label": "CA1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.301",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3038",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "dichlorphenamide targets CA12",
"source_label": "dichlorphenamide",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.301",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3038",
"relation": "IDG (Drug Target)",
"target": "377677",
"properties": {
"id": "dichlorphenamide targets CA13",
"source_label": "dichlorphenamide",
"target_label": "CA13",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.64",
"act_comment": "Inhibition of human recombinant cytosolic carbonic anhydrase 13 preincubated for 15 mins by stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3038",
"relation": "IDG (Drug Target)",
"target": "23632",
"properties": {
"id": "dichlorphenamide targets CA14",
"source_label": "dichlorphenamide",
"target_label": "CA14",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3038",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "dichlorphenamide targets CA2",
"source_label": "dichlorphenamide",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3038",
"relation": "IDG (Drug Target)",
"target": "762",
"properties": {
"id": "dichlorphenamide targets CA4",
"source_label": "dichlorphenamide",
"target_label": "CA4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.02",
"act_comment": "Inhibition of human full length carbonic anhydrase 4 by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3038",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "dichlorphenamide targets CA5A",
"source_label": "dichlorphenamide",
"target_label": "CA5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.201",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3038",
"relation": "IDG (Drug Target)",
"target": "11238",
"properties": {
"id": "dichlorphenamide targets CA5B",
"source_label": "dichlorphenamide",
"target_label": "CA5B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.678",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3038",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "dichlorphenamide targets CA6",
"source_label": "dichlorphenamide",
"target_label": "CA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "Inhibition of full length human recombinant CA VI",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3038",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "dichlorphenamide targets CA7",
"source_label": "dichlorphenamide",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.577",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3038",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "dichlorphenamide targets CA9",
"source_label": "dichlorphenamide",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.301",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3033",
"relation": "IDG (Drug Target)",
"target": "3576",
"properties": {
"id": "diclofenac targets CXCL8",
"source_label": "diclofenac",
"target_label": "CXCL8",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3033",
"relation": "IDG (Drug Target)",
"target": "3577",
"properties": {
"id": "diclofenac targets CXCR1",
"source_label": "diclofenac",
"target_label": "CXCR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Inhibition of wild type CXCR1 transfected in mouse L1.2 cells assessed as inhibition of CXCL8-induced cell migration pretreated for 15 mins measured after 4 hrs",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3033",
"relation": "IDG (Drug Target)",
"target": "5468",
"properties": {
"id": "diclofenac targets PPARG",
"source_label": "diclofenac",
"target_label": "PPARG",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3033",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "diclofenac targets PTGS1",
"source_label": "diclofenac",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3033",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "diclofenac targets PTGS2",
"source_label": "diclofenac",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3033",
"relation": "IDG (Drug Target)",
"target": "7276",
"properties": {
"id": "diclofenac targets TTR",
"source_label": "diclofenac",
"target_label": "TTR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:54676038",
"relation": "IDG (Drug Target)",
"target": "2859",
"properties": {
"id": "dicoumarol targets GPR35",
"source_label": "dicoumarol",
"target_label": "GPR35",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.41",
"act_comment": "Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:54676038",
"relation": "IDG (Drug Target)",
"target": "1728",
"properties": {
"id": "dicoumarol targets NQO1",
"source_label": "dicoumarol",
"target_label": "NQO1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3042",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "dicycloverine targets CHRM1",
"source_label": "dicycloverine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.079",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3042",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "dicycloverine targets CHRM2",
"source_label": "dicycloverine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3042",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "dicycloverine targets CHRM3",
"source_label": "dicycloverine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.033",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3042",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "dicycloverine targets CHRM4",
"source_label": "dicycloverine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.386",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3042",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "dicycloverine targets CHRM5",
"source_label": "dicycloverine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.767",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3042",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "dicycloverine targets DRD3",
"source_label": "dicycloverine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.386",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3042",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "dicycloverine targets HTR2A",
"source_label": "dicycloverine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.161",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3042",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "dicycloverine targets HTR2B",
"source_label": "dicycloverine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.082",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3042",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "dicycloverine targets HTR2C",
"source_label": "dicycloverine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.611",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3042",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "dicycloverine targets SIGMAR1",
"source_label": "dicycloverine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.686",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:448537",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "diethylstilbestrol targets ESR1",
"source_label": "diethylstilbestrol",
"target_label": "ESR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.66",
"act_comment": "Displacement of [3H]Estradiol from human recombinant estrogen receptor alpha expressed in Sf9 cells after 2 hrs",
"act_source": "CHEMBL"
}
},
{
"source": "CID:448537",
"relation": "IDG (Drug Target)",
"target": "2100",
"properties": {
"id": "diethylstilbestrol targets ESR2",
"source_label": "diethylstilbestrol",
"target_label": "ESR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.2",
"act_comment": "In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor beta",
"act_source": "CHEMBL"
}
},
{
"source": "CID:448537",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "diethylstilbestrol targets OPRD1",
"source_label": "diethylstilbestrol",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.019",
"act_comment": "DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:448537",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "diethylstilbestrol targets SLC6A3",
"source_label": "diethylstilbestrol",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3059",
"relation": "IDG (Drug Target)",
"target": "7276",
"properties": {
"id": "diflunisal targets TTR",
"source_label": "diflunisal",
"target_label": "TTR",
"act_type": "Kd1",
"act_relation": "=",
"act_value": "7.125",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5702041",
"relation": "IDG (Drug Target)",
"target": "6774",
"properties": {
"id": "digitoxin targets STAT3",
"source_label": "digitoxin",
"target_label": "STAT3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "PUBCHEM_BIOASSAY: Dose response cell-based assay to measure STAT3 inhibition. (Class of assay: confirmatory) [Related pubchem assays: 920, 1317, 1265, 1308, 862 ]",
"act_source": "CHEMBL"
}
},
{
"source": "CID:134551",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "alpha-Ergocryptine targets ADRA1D",
"source_label": "alpha-Ergocryptine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.369",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
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}
},
{
"source": "CID:134551",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:134551",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:134551",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:134551",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:134551",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:134551",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:134551",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:134551",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:134551",
"relation": "IDG (Drug Target)",
"target": "3356",
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}
},
{
"source": "CID:134551",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "alpha-Ergocryptine targets HTR2B",
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}
},
{
"source": "CID:134551",
"relation": "IDG (Drug Target)",
"target": "3358",
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"id": "alpha-Ergocryptine targets HTR2C",
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}
},
{
"source": "CID:134551",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:134551",
"relation": "IDG (Drug Target)",
"target": "4988",
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}
},
{
"source": "CID:107715",
"relation": "IDG (Drug Target)",
"target": "146",
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"id": "dihydroergocristine targets ADRA1D",
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}
},
{
"source": "CID:107715",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:107715",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:107715",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:107715",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:107715",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:107715",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:107715",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:107715",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:107715",
"relation": "IDG (Drug Target)",
"target": "3357",
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}
},
{
"source": "CID:107715",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:107715",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:107715",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:10531",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:10531",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:10531",
"relation": "IDG (Drug Target)",
"target": "151",
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}
},
{
"source": "CID:10531",
"relation": "IDG (Drug Target)",
"target": "152",
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}
},
{
"source": "CID:10531",
"relation": "IDG (Drug Target)",
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"properties": {
"id": "dihydroergotamine targets DRD2",
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"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:10531",
"relation": "IDG (Drug Target)",
"target": "1814",
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"id": "dihydroergotamine targets DRD3",
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}
},
{
"source": "CID:10531",
"relation": "IDG (Drug Target)",
"target": "3350",
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}
},
{
"source": "CID:10531",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
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"act_value": "9.2",
"act_comment": "nan",
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}
},
{
"source": "CID:10531",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "dihydroergotamine targets HTR1D",
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}
},
{
"source": "CID:10531",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "dihydroergotamine targets HTR1F",
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"act_value": "7.1",
"act_comment": "nan",
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}
},
{
"source": "CID:10531",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "dihydroergotamine targets HTR2A",
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"act_relation": "=",
"act_value": "8.644",
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"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:10531",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "dihydroergotamine targets HTR2B",
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"act_relation": "=",
"act_value": "8.364",
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"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:10531",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "dihydroergotamine targets HTR2C",
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"act_relation": "=",
"act_value": "7.328",
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"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:10531",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "dihydroergotamine targets HTR6",
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"act_relation": "=",
"act_value": "8.83",
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}
},
{
"source": "CID:10531",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "dihydroergotamine targets HTR7",
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"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
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}
},
{
"source": "CID:3074",
"relation": "IDG (Drug Target)",
"target": "2030",
"properties": {
"id": "dilazep targets SLC29A1",
"source_label": "dilazep",
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"act_value": "9.0",
"act_comment": "GRAC: human ENT1 selective inhibitor",
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}
},
{
"source": "CID:39186",
"relation": "IDG (Drug Target)",
"target": "775",
"properties": {
"id": "diltiazem targets CACNA1C",
"source_label": "diltiazem",
"target_label": "CACNA1C",
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"act_relation": "=",
"act_value": "7.319",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:39186",
"relation": "IDG (Drug Target)",
"target": "779",
"properties": {
"id": "diltiazem targets CACNA1S",
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"act_value": "6.42",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:39186",
"relation": "IDG (Drug Target)",
"target": "786",
"properties": {
"id": "diltiazem targets CACNG1",
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"act_relation": "=",
"act_value": "6.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:21855",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "dimetindene targets CHRM1",
"source_label": "dimetindene",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.58",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:21855",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "dimetindene targets CHRM2",
"source_label": "dimetindene",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.35",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:21855",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "dimetindene targets CHRM3",
"source_label": "dimetindene",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:21855",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "dimetindene targets CHRM4",
"source_label": "dimetindene",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:21855",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "dimetindene targets CHRM5",
"source_label": "dimetindene",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:21855",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "dimetindene targets HRH1",
"source_label": "dimetindene",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.16",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280363",
"relation": "IDG (Drug Target)",
"target": "11251",
"properties": {
"id": "dinoprost targets PTGDR2",
"source_label": "dinoprost",
"target_label": "PTGDR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5280363",
"relation": "IDG (Drug Target)",
"target": "5731",
"properties": {
"id": "dinoprost targets PTGER1",
"source_label": "dinoprost",
"target_label": "PTGER1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "In vitro binding at EP1 human prostaglandin receptor using [3H]PGE-2 as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280363",
"relation": "IDG (Drug Target)",
"target": "5732",
"properties": {
"id": "dinoprost targets PTGER2",
"source_label": "dinoprost",
"target_label": "PTGER2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5280363",
"relation": "IDG (Drug Target)",
"target": "5733",
"properties": {
"id": "dinoprost targets PTGER3",
"source_label": "dinoprost",
"target_label": "PTGER3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "In vitro binding at EP3 human prostaglandin receptor using [3H]PGE-2 as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280363",
"relation": "IDG (Drug Target)",
"target": "5737",
"properties": {
"id": "dinoprost targets PTGFR",
"source_label": "dinoprost",
"target_label": "PTGFR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "GRAC: human FP probe",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280360",
"relation": "IDG (Drug Target)",
"target": "117144",
"properties": {
"id": "dinoprostone targets CATSPER1",
"source_label": "dinoprostone",
"target_label": "CATSPER1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Patch clamp electrophysiology",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5280360",
"relation": "IDG (Drug Target)",
"target": "117155",
"properties": {
"id": "dinoprostone targets CATSPER2",
"source_label": "dinoprostone",
"target_label": "CATSPER2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Patch clamp electrophysiology.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5280360",
"relation": "IDG (Drug Target)",
"target": "347732",
"properties": {
"id": "dinoprostone targets CATSPER3",
"source_label": "dinoprostone",
"target_label": "CATSPER3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Patch clamp electrophysiology.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5280360",
"relation": "IDG (Drug Target)",
"target": "378807",
"properties": {
"id": "dinoprostone targets CATSPER4",
"source_label": "dinoprostone",
"target_label": "CATSPER4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Patch clamp electrophysiology.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5280360",
"relation": "IDG (Drug Target)",
"target": "5729",
"properties": {
"id": "dinoprostone targets PTGDR",
"source_label": "dinoprostone",
"target_label": "PTGDR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5280360",
"relation": "IDG (Drug Target)",
"target": "5731",
"properties": {
"id": "dinoprostone targets PTGER1",
"source_label": "dinoprostone",
"target_label": "PTGER1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.04",
"act_comment": "Displacement of [3H]PGE2 from human EP1 receptor expressed in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280360",
"relation": "IDG (Drug Target)",
"target": "5732",
"properties": {
"id": "dinoprostone targets PTGER2",
"source_label": "dinoprostone",
"target_label": "PTGER2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.77",
"act_comment": "Binding affinity to human prostanoid EP2 receptor by radioligand displacement assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280360",
"relation": "IDG (Drug Target)",
"target": "5733",
"properties": {
"id": "dinoprostone targets PTGER3",
"source_label": "dinoprostone",
"target_label": "PTGER3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.48",
"act_comment": "Displacement of [3H]PGE2 from human EP3 receptor expressed in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280360",
"relation": "IDG (Drug Target)",
"target": "5734",
"properties": {
"id": "dinoprostone targets PTGER4",
"source_label": "dinoprostone",
"target_label": "PTGER4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.77",
"act_comment": "Binding affinity to human prostanoid EP4 receptor by radioligand displacement assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280360",
"relation": "IDG (Drug Target)",
"target": "5737",
"properties": {
"id": "dinoprostone targets PTGFR",
"source_label": "dinoprostone",
"target_label": "PTGFR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5280360",
"relation": "IDG (Drug Target)",
"target": "5739",
"properties": {
"id": "dinoprostone targets PTGIR",
"source_label": "dinoprostone",
"target_label": "PTGIR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "Agonist activity at prostanoid IP receptor (unknown origin) by functional assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3100",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "diphenhydramine targets CHRM1",
"source_label": "diphenhydramine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3100",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "diphenhydramine targets CHRM2",
"source_label": "diphenhydramine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.921",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3100",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "diphenhydramine targets CHRM3",
"source_label": "diphenhydramine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3100",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "diphenhydramine targets CHRM4",
"source_label": "diphenhydramine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.951",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3100",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "diphenhydramine targets CHRM5",
"source_label": "diphenhydramine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.585",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3100",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "diphenhydramine targets HRH1",
"source_label": "diphenhydramine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.81",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3100",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "diphenhydramine targets HTR2A",
"source_label": "diphenhydramine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.432",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3100",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "diphenhydramine targets HTR2B",
"source_label": "diphenhydramine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.148",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3100",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "diphenhydramine targets HTR2C",
"source_label": "diphenhydramine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3100",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "diphenhydramine targets SLC6A2",
"source_label": "diphenhydramine",
"target_label": "SLC6A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.018",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:13505",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "diphenoxylate targets OPRM1",
"source_label": "diphenoxylate",
"target_label": "OPRM1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.167",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3103",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "diphenylpyraline targets CHRM1",
"source_label": "diphenylpyraline",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.699",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3103",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "diphenylpyraline targets HRH1",
"source_label": "diphenylpyraline",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.076",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3103",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "diphenylpyraline targets SLC6A3",
"source_label": "diphenylpyraline",
"target_label": "SLC6A3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.377",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3108",
"relation": "IDG (Drug Target)",
"target": "10846",
"properties": {
"id": "dipyridamole targets PDE10A",
"source_label": "dipyridamole",
"target_label": "PDE10A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Inhibitory activity against phosphodiesterase 10",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3108",
"relation": "IDG (Drug Target)",
"target": "50940",
"properties": {
"id": "dipyridamole targets PDE11A",
"source_label": "dipyridamole",
"target_label": "PDE11A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Inhibition of human phosphodiesterase 11",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3108",
"relation": "IDG (Drug Target)",
"target": "8654",
"properties": {
"id": "dipyridamole targets PDE5A",
"source_label": "dipyridamole",
"target_label": "PDE5A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3108",
"relation": "IDG (Drug Target)",
"target": "27115",
"properties": {
"id": "dipyridamole targets PDE7B",
"source_label": "dipyridamole",
"target_label": "PDE7B",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "GRAC: human PDE7B selective inhibitor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3108",
"relation": "IDG (Drug Target)",
"target": "58497",
"properties": {
"id": "dipyridamole targets PRUNE1",
"source_label": "dipyridamole",
"target_label": "PRUNE1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Inhibition of human prune assessed as reduction of cAMP-phosphodiesterase activity",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3108",
"relation": "IDG (Drug Target)",
"target": "9154",
"properties": {
"id": "dipyridamole targets SLC28A1",
"source_label": "dipyridamole",
"target_label": "SLC28A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.538",
"act_comment": "DRUGMATRIX: Sodium/nucleoside co-transporter radioligand binding (ligand: nitrobenzylthioinosine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3108",
"relation": "IDG (Drug Target)",
"target": "2030",
"properties": {
"id": "dipyridamole targets SLC29A1",
"source_label": "dipyridamole",
"target_label": "SLC29A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.5",
"act_comment": "GRAC: human ENT1 selective inhibitor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3117",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "disulfiram targets ADORA3",
"source_label": "disulfiram",
"target_label": "ADORA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.697",
"act_comment": "DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3117",
"relation": "IDG (Drug Target)",
"target": "729230",
"properties": {
"id": "disulfiram targets CCR2",
"source_label": "disulfiram",
"target_label": "CCR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3117",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "disulfiram targets DRD3",
"source_label": "disulfiram",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.434",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3117",
"relation": "IDG (Drug Target)",
"target": "10919",
"properties": {
"id": "disulfiram targets EHMT2",
"source_label": "disulfiram",
"target_label": "EHMT2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Inhibition of wild type recombinant human histone lysine methyltransferase G9a (913 to 1193 residues) expressed in Escherichia coli Rosetta BL21 DE3 PlysS using ARTKQTARKSTGGKA as substrate preincubated for 5 mins followed by substrate/SAM addition measured after 60 mins by MALDI-TOF MS analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3117",
"relation": "IDG (Drug Target)",
"target": "2203",
"properties": {
"id": "disulfiram targets FBP1",
"source_label": "disulfiram",
"target_label": "FBP1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Inhibition of human liver FBPase C38S mutant expressed in Escherichia coli BL21 (DE3) using FBP as substrate incubated for 5 mins by malachite green dye based assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3117",
"relation": "IDG (Drug Target)",
"target": "79792",
"properties": {
"id": "disulfiram targets GSDMD",
"source_label": "disulfiram",
"target_label": "GSDMD",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Inhibition of GSDMD in human monocyte/macrophages assessed as inhibition of pyroptosis in presence of Cu2+",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3117",
"relation": "IDG (Drug Target)",
"target": "4015",
"properties": {
"id": "disulfiram targets LOX",
"source_label": "disulfiram",
"target_label": "LOX",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "Inhibition of recombinant human LOX expressed in HEK293 cells using diaminopentane as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr by fluorimetric method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3117",
"relation": "IDG (Drug Target)",
"target": "4017",
"properties": {
"id": "disulfiram targets LOXL2",
"source_label": "disulfiram",
"target_label": "LOXL2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "Inhibition of recombinant LOXL2 (unknown origin) expressed in NS0 cells using diaminopentane as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr by fluorimetric method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3117",
"relation": "IDG (Drug Target)",
"target": "84695",
"properties": {
"id": "disulfiram targets LOXL3",
"source_label": "disulfiram",
"target_label": "LOXL3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.03",
"act_comment": "Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr by fluorimetric method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3117",
"relation": "IDG (Drug Target)",
"target": "84171",
"properties": {
"id": "disulfiram targets LOXL4",
"source_label": "disulfiram",
"target_label": "LOXL4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.23",
"act_comment": "Inhibition of recombinant human LOXL4 expressed in baculovirus infected insect cells using diaminopentane as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr by fluorimetric method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:8987",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "ditiocarb targets CA1",
"source_label": "ditiocarb",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 1-catalyzed CO2 hydration by stopped flow assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:8987",
"relation": "IDG (Drug Target)",
"target": "1571",
"properties": {
"id": "ditiocarb targets CYP2E1",
"source_label": "ditiocarb",
"target_label": "CYP2E1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "Fluorescent High Throughput P450 Assays: The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest) The IC50s of the compounds was calculated on isoenzymes (CYP1A2, CYP2C9, CYP2C19, CYP2C8, CYP2B6, CYP2D6, CYP2E1, CYP3A4 and CYP3A5).Materials and Methods: Inhibition of the P450 isoforms was measured in specific assays using specific substrates that become fluorescent upon CYP metabolism. Compounds, dissolved in ACN (acetonitrile) (CYP2E1, CYP2C8, CYP2B6, CYP3A5) or DMSO (all remaining isoforms), were tested in duplicate (n=2) in concentration-response curves (eight concentrations) in a 96-well plate containing incubation/NADPH regenerating buffer. Specific isoenzymes and substrates were added and incubated at 37\u00c2\u00b0 C. Reactions were terminated at different times, depending on the assays, and plates read on a Fluoroskan Ascent at the appropriate emission/excitation wavelengths.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:8987",
"relation": "IDG (Drug Target)",
"target": "79792",
"properties": {
"id": "ditiocarb targets GSDMD",
"source_label": "ditiocarb",
"target_label": "GSDMD",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Inhibition of GSDMD in human monocyte/macrophages assessed as inhibition of pyroptosis in presence of Cu2+",
"act_source": "CHEMBL"
}
},
{
"source": "CID:36811",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "dobutamine targets ADRA1D",
"source_label": "dobutamine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.347",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:36811",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "dobutamine targets ADRB2",
"source_label": "dobutamine",
"target_label": "ADRB2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:36811",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "dobutamine targets CA2",
"source_label": "dobutamine",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.32",
"act_comment": "Inhibition of human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:36811",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "dobutamine targets CA5A",
"source_label": "dobutamine",
"target_label": "CA5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Inhibition of human carbonic anhydrase 5a after 15 mins by stopped flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:36811",
"relation": "IDG (Drug Target)",
"target": "11238",
"properties": {
"id": "dobutamine targets CA5B",
"source_label": "dobutamine",
"target_label": "CA5B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Inhibition of human carbonic anhydrase 5b after 15 mins by stopped flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:36811",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "dobutamine targets SLC6A2",
"source_label": "dobutamine",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:36811",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "dobutamine targets SLC6A3",
"source_label": "dobutamine",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.91",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:148124",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "docetaxel targets EGFR",
"source_label": "docetaxel",
"target_label": "EGFR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.086",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:148124",
"relation": "IDG (Drug Target)",
"target": "2692",
"properties": {
"id": "docetaxel targets GHRHR",
"source_label": "docetaxel",
"target_label": "GHRHR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.85",
"act_comment": "Displacement of [125I]JV1-42 from GHRH receptor expressed in human MX1 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:148124",
"relation": "IDG (Drug Target)",
"target": "6865",
"properties": {
"id": "docetaxel targets TACR2",
"source_label": "docetaxel",
"target_label": "TACR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.283",
"act_comment": "DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:71329",
"relation": "IDG (Drug Target)",
"target": "3756",
"properties": {
"id": "dofetilide targets KCNH1",
"source_label": "dofetilide",
"target_label": "KCNH1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:71329",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "dofetilide targets KCNH2",
"source_label": "dofetilide",
"target_label": "KCNH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.19",
"act_comment": "Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3151",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "domperidone targets ADRA1A",
"source_label": "domperidone",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.65",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3151",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "domperidone targets ADRA1B",
"source_label": "domperidone",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.276",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3151",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "domperidone targets ADRA1D",
"source_label": "domperidone",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.936",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3151",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "domperidone targets ADRA2B",
"source_label": "domperidone",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.013",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3151",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "domperidone targets ADRA2C",
"source_label": "domperidone",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.833",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3151",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "domperidone targets DRD2",
"source_label": "domperidone",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3151",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "domperidone targets DRD3",
"source_label": "domperidone",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.46",
"act_comment": "Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3151",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "domperidone targets HRH1",
"source_label": "domperidone",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.807",
"act_comment": "DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3151",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "domperidone targets HTR2A",
"source_label": "domperidone",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.959",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3151",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "domperidone targets HTR2C",
"source_label": "domperidone",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.156",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3151",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "domperidone targets KCNH2",
"source_label": "domperidone",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.79",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3152",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "donepezil targets ACHE",
"source_label": "donepezil",
"target_label": "ACHE",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3152",
"relation": "IDG (Drug Target)",
"target": "11255",
"properties": {
"id": "donepezil targets HRH3",
"source_label": "donepezil",
"target_label": "HRH3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Inhibition of histamine H3 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3152",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "donepezil targets SIGMAR1",
"source_label": "donepezil",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.84",
"act_comment": "Displacement of [3H]DTG from sigma 1 receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:681",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "dopamine targets DRD1",
"source_label": "dopamine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:681",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "dopamine targets DRD2",
"source_label": "dopamine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:681",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "dopamine targets DRD3",
"source_label": "dopamine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:681",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "dopamine targets DRD4",
"source_label": "dopamine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:681",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "dopamine targets DRD5",
"source_label": "dopamine",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:681",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "dopamine targets SLC6A2",
"source_label": "dopamine",
"target_label": "SLC6A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.18",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:681",
"relation": "IDG (Drug Target)",
"target": "134864",
"properties": {
"id": "dopamine targets TAAR1",
"source_label": "dopamine",
"target_label": "TAAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.375",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284549",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "dorzolamide targets CA1",
"source_label": "dorzolamide",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Inhibition of human cloned CA1 by CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284549",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "dorzolamide targets CA12",
"source_label": "dorzolamide",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.46",
"act_comment": "Inhibitory activity against catalytic domain of human carbonic anhydrase XII",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284549",
"relation": "IDG (Drug Target)",
"target": "377677",
"properties": {
"id": "dorzolamide targets CA13",
"source_label": "dorzolamide",
"target_label": "CA13",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.74",
"act_comment": "Inhibition of human carbonic anhydrase13 preincubated for 15 mins by stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284549",
"relation": "IDG (Drug Target)",
"target": "23632",
"properties": {
"id": "dorzolamide targets CA14",
"source_label": "dorzolamide",
"target_label": "CA14",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.57",
"act_comment": "Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284549",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "dorzolamide targets CA2",
"source_label": "dorzolamide",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 2 by dansylamide (DNSA) competition assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284549",
"relation": "IDG (Drug Target)",
"target": "762",
"properties": {
"id": "dorzolamide targets CA4",
"source_label": "dorzolamide",
"target_label": "CA4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.37",
"act_comment": "Inhibition of cloned isozyme, human carbonic anhydrase IV",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284549",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "dorzolamide targets CA5A",
"source_label": "dorzolamide",
"target_label": "CA5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.38",
"act_comment": "Inhibitory activity against human recombinant mitochondrial isozyme CA VA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284549",
"relation": "IDG (Drug Target)",
"target": "11238",
"properties": {
"id": "dorzolamide targets CA5B",
"source_label": "dorzolamide",
"target_label": "CA5B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.48",
"act_comment": "Inhibitory activity against human recombinant mitochondrial isozyme CA VB",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284549",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "dorzolamide targets CA6",
"source_label": "dorzolamide",
"target_label": "CA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Inhibition of full length human recombinant CA VI",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284549",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "dorzolamide targets CA7",
"source_label": "dorzolamide",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.46",
"act_comment": "Ki value against human carbonic anhydrase VII",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284549",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "dorzolamide targets CA9",
"source_label": "dorzolamide",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.28",
"act_comment": "Inhibitory activity against human carbonic anhydrase IX (hCA IX) by using CO2 hydrase assay method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284550",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "dosulepin targets ADRA1A",
"source_label": "dosulepin",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.378",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284550",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "dosulepin targets ADRA2B",
"source_label": "dosulepin",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.921",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284550",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "dosulepin targets CHRM1",
"source_label": "dosulepin",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.744",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284550",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "dosulepin targets CHRM2",
"source_label": "dosulepin",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.963",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284550",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "dosulepin targets CHRM3",
"source_label": "dosulepin",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284550",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "dosulepin targets CHRM4",
"source_label": "dosulepin",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.215",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284550",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "dosulepin targets CHRM5",
"source_label": "dosulepin",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.036",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284550",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "dosulepin targets HRH1",
"source_label": "dosulepin",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.699",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284550",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "dosulepin targets HTR2A",
"source_label": "dosulepin",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.588",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284550",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "dosulepin targets SLC6A2",
"source_label": "dosulepin",
"target_label": "SLC6A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.337",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284550",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "dosulepin targets SLC6A4",
"source_label": "dosulepin",
"target_label": "SLC6A4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.066",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3156",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "doxapram targets CYP2D6",
"source_label": "doxapram",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3157",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "doxazosin targets ADRA1A",
"source_label": "doxazosin",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3157",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "doxazosin targets ADRA1B",
"source_label": "doxazosin",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3157",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "doxazosin targets ADRA1D",
"source_label": "doxazosin",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.85",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3157",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "doxazosin targets ADRA2A",
"source_label": "doxazosin",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Binding affinity against Alpha-2A adrenergic receptor, from human clones.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3157",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "doxazosin targets ADRA2C",
"source_label": "doxazosin",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Binding affinity against Alpha-2C adrenergic receptor from human clones.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3157",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "doxazosin targets HTR2B",
"source_label": "doxazosin",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.631",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3157",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "doxazosin targets HTR2C",
"source_label": "doxazosin",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.545",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3157",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "doxazosin targets KCNH2",
"source_label": "doxazosin",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.23",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3157",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "doxazosin targets SLC6A3",
"source_label": "doxazosin",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.827",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "doxepin targets ADRA1A",
"source_label": "doxepin",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.629",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "doxepin targets ADRA1D",
"source_label": "doxepin",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.367",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "doxepin targets ADRA2A",
"source_label": "doxepin",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "doxepin targets ADRA2B",
"source_label": "doxepin",
"target_label": "ADRA2B",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.21",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "doxepin targets ADRA2C",
"source_label": "doxepin",
"target_label": "ADRA2C",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "doxepin targets CHRM1",
"source_label": "doxepin",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "doxepin targets CHRM2",
"source_label": "doxepin",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.796",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "doxepin targets CHRM3",
"source_label": "doxepin",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.284",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "doxepin targets CHRM4",
"source_label": "doxepin",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.086",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "doxepin targets CHRM5",
"source_label": "doxepin",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.125",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "doxepin targets DRD1",
"source_label": "doxepin",
"target_label": "DRD1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "doxepin targets DRD2",
"source_label": "doxepin",
"target_label": "DRD2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "doxepin targets DRD3",
"source_label": "doxepin",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.325",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "doxepin targets HRH1",
"source_label": "doxepin",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.75",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "59340",
"properties": {
"id": "doxepin targets HRH4",
"source_label": "doxepin",
"target_label": "HRH4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.79",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "doxepin targets HTR1A",
"source_label": "doxepin",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.538",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "doxepin targets HTR2A",
"source_label": "doxepin",
"target_label": "HTR2A",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.45",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "doxepin targets HTR2B",
"source_label": "doxepin",
"target_label": "HTR2B",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "doxepin targets HTR2C",
"source_label": "doxepin",
"target_label": "HTR2C",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "doxepin targets HTR6",
"source_label": "doxepin",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.98",
"act_comment": "Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1.5 hrs by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "doxepin targets SIGMAR1",
"source_label": "doxepin",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.577",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "doxepin targets SLC6A2",
"source_label": "doxepin",
"target_label": "SLC6A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.53",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:667477",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "doxepin targets SLC6A4",
"source_label": "doxepin",
"target_label": "SLC6A4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.17",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:31703",
"relation": "IDG (Drug Target)",
"target": "6790",
"properties": {
"id": "doxorubicin targets AURKA",
"source_label": "doxorubicin",
"target_label": "AURKA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "Inhibition of GST-tagged Aurora A kinase expressed in insect cells assessed as inhibition of [33P]gamma-ATP incorporation in substrate after 60 mins by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:31703",
"relation": "IDG (Drug Target)",
"target": "7153",
"properties": {
"id": "doxorubicin targets TOP2A",
"source_label": "doxorubicin",
"target_label": "TOP2A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Inhibition human placenta topoisomerase 2 assessed as conversion of supercoiled pBR322 DNA to relaxed form",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3168",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "droperidol targets ADRA1D",
"source_label": "droperidol",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.175",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3168",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "droperidol targets ADRA2B",
"source_label": "droperidol",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.996",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3168",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "droperidol targets ADRA2C",
"source_label": "droperidol",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.592",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3168",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "droperidol targets CHRM4",
"source_label": "droperidol",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.27",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3168",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "droperidol targets DRD1",
"source_label": "droperidol",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.263",
"act_comment": "DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3168",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "droperidol targets DRD2",
"source_label": "droperidol",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.602",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3168",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "droperidol targets DRD3",
"source_label": "droperidol",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.027",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3168",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "droperidol targets DRD4",
"source_label": "droperidol",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.076",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3168",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "droperidol targets HRH1",
"source_label": "droperidol",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3168",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "droperidol targets HTR1A",
"source_label": "droperidol",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.86",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3168",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "droperidol targets HTR2A",
"source_label": "droperidol",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.132",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3168",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "droperidol targets HTR2B",
"source_label": "droperidol",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.069",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3168",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "droperidol targets HTR2C",
"source_label": "droperidol",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.623",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3168",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "droperidol targets KCNH2",
"source_label": "droperidol",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.49",
"act_comment": "Inhibition of human Potassium channel HERG expressed in mammalian cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68873",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "drospirenone targets AR",
"source_label": "drospirenone",
"target_label": "AR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:68873",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "drospirenone targets NR3C2",
"source_label": "drospirenone",
"target_label": "NR3C2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:68873",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "drospirenone targets PGR",
"source_label": "drospirenone",
"target_label": "PGR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "10.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:92974",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "droxidopa targets CHRM1",
"source_label": "droxidopa",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:60835",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "duloxetine targets HTR2A",
"source_label": "duloxetine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:60835",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "duloxetine targets HTR2C",
"source_label": "duloxetine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:60835",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "duloxetine targets HTR6",
"source_label": "duloxetine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:60835",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "duloxetine targets SLC6A2",
"source_label": "duloxetine",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "Inhibition of human NET",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60835",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "duloxetine targets SLC6A3",
"source_label": "duloxetine",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Ability to inhibit the reuptake of dopamine at human dopamine transporter",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60835",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "duloxetine targets SLC6A4",
"source_label": "duloxetine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.62",
"act_comment": "Displacement of [3H]citalopram from human SERT transfected in HEK293 cells after 3 hrs by Wallac counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918296",
"relation": "IDG (Drug Target)",
"target": "2741",
"properties": {
"id": "dutasteride targets GLRA1",
"source_label": "dutasteride",
"target_label": "GLRA1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918296",
"relation": "IDG (Drug Target)",
"target": "6715",
"properties": {
"id": "dutasteride targets SRD5A1",
"source_label": "dutasteride",
"target_label": "SRD5A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.49",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6918296",
"relation": "IDG (Drug Target)",
"target": "6716",
"properties": {
"id": "dutasteride targets SRD5A2",
"source_label": "dutasteride",
"target_label": "SRD5A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3180",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "dyclonine targets ACHE",
"source_label": "dyclonine",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Inhibition of AChE (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9051",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "dydrogesterone targets PGR",
"source_label": "dydrogesterone",
"target_label": "PGR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "ebastine targets ADRA1D",
"source_label": "ebastine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.06",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "ebastine targets ADRA2A",
"source_label": "ebastine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.506",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "ebastine targets ADRA2B",
"source_label": "ebastine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.472",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "ebastine targets ADRA2C",
"source_label": "ebastine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.397",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "ebastine targets CHRM2",
"source_label": "ebastine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.554",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "ebastine targets CHRM3",
"source_label": "ebastine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.863",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "ebastine targets CHRM4",
"source_label": "ebastine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.937",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "ebastine targets CHRM5",
"source_label": "ebastine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.615",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "ebastine targets DRD1",
"source_label": "ebastine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.224",
"act_comment": "DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "ebastine targets DRD2",
"source_label": "ebastine",
"target_label": "DRD2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.21",
"act_comment": "Compound is evaluated for in vitro receptor binding affinity against Dopamine receptor D2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "ebastine targets DRD3",
"source_label": "ebastine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.384",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "ebastine targets DRD4",
"source_label": "ebastine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.341",
"act_comment": "DRUGMATRIX: Dopamine D4.2 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "ebastine targets EGFR",
"source_label": "ebastine",
"target_label": "EGFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.253",
"act_comment": "DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr))",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "2534",
"properties": {
"id": "ebastine targets FYN",
"source_label": "ebastine",
"target_label": "FYN",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.091",
"act_comment": "DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr))",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "ebastine targets HRH1",
"source_label": "ebastine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "ebastine targets HTR1A",
"source_label": "ebastine",
"target_label": "HTR1A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.33",
"act_comment": "Compound is evaluated for in vitro receptor binding affinity against 5-hydroxytryptamine 1A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "ebastine targets HTR2A",
"source_label": "ebastine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.588",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "ebastine targets HTR2B",
"source_label": "ebastine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.701",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "ebastine targets HTR2C",
"source_label": "ebastine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.905",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "ebastine targets KCNH2",
"source_label": "ebastine",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "ebastine targets SLC6A2",
"source_label": "ebastine",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.341",
"act_comment": "DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "ebastine targets SLC6A3",
"source_label": "ebastine",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.106",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "ebastine targets SLC6A4",
"source_label": "ebastine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.185",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3191",
"relation": "IDG (Drug Target)",
"target": "6865",
"properties": {
"id": "ebastine targets TACR2",
"source_label": "ebastine",
"target_label": "TACR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.191",
"act_comment": "DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3198",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "econazole targets CHRM1",
"source_label": "econazole",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.197",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3198",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "econazole targets CHRM3",
"source_label": "econazole",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.421",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3198",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "econazole targets CHRM4",
"source_label": "econazole",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.529",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3198",
"relation": "IDG (Drug Target)",
"target": "1586",
"properties": {
"id": "econazole targets CYP17A1",
"source_label": "econazole",
"target_label": "CYP17A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.49",
"act_comment": "In vitro inhibition of human Cytochrome P450 17A1 activity",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3198",
"relation": "IDG (Drug Target)",
"target": "1544",
"properties": {
"id": "econazole targets CYP1A2",
"source_label": "econazole",
"target_label": "CYP1A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.523",
"act_comment": "DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3198",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "econazole targets CYP2C19",
"source_label": "econazole",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.398",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3198",
"relation": "IDG (Drug Target)",
"target": "1559",
"properties": {
"id": "econazole targets CYP2C9",
"source_label": "econazole",
"target_label": "CYP2C9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.699",
"act_comment": "DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3198",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "econazole targets CYP2D6",
"source_label": "econazole",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.398",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3198",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "econazole targets CYP3A4",
"source_label": "econazole",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.301",
"act_comment": "DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3198",
"relation": "IDG (Drug Target)",
"target": "1595",
"properties": {
"id": "econazole targets CYP51A1",
"source_label": "econazole",
"target_label": "CYP51A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3198",
"relation": "IDG (Drug Target)",
"target": "1582",
"properties": {
"id": "econazole targets CYP8B1",
"source_label": "econazole",
"target_label": "CYP8B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "Inhibition of CYP8B1 in human liver microsomes using D7-7alpha-hydroxy-4-cholesten-3-one as substrate preincubated for 20 mins followed by substrate addition in presence of NADPH by UPLC-ESI-MS/MS analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3198",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "econazole targets OPRD1",
"source_label": "econazole",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.294",
"act_comment": "DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3198",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "econazole targets SLC6A3",
"source_label": "econazole",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.178",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3198",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "econazole targets SLC6A4",
"source_label": "econazole",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.648",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3198",
"relation": "IDG (Drug Target)",
"target": "6916",
"properties": {
"id": "econazole targets TBXAS1",
"source_label": "econazole",
"target_label": "TBXAS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.538",
"act_comment": "DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6917908",
"relation": "IDG (Drug Target)",
"target": "1719",
"properties": {
"id": "edatrexate targets DHFR",
"source_label": "edatrexate",
"target_label": "DHFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.36",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3202",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "edrophonium targets ACHE",
"source_label": "edrophonium",
"target_label": "ACHE",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.79",
"act_comment": "Inhibition constant determined against Acetylcholinesterase (AChE) receptor.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:64139",
"relation": "IDG (Drug Target)",
"target": "10858",
"properties": {
"id": "efavirenz targets CYP46A1",
"source_label": "efavirenz",
"target_label": "CYP46A1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by UV-spectrophotometric method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:119171",
"relation": "IDG (Drug Target)",
"target": "8912",
"properties": {
"id": "efonidipine targets CACNA1H",
"source_label": "efonidipine",
"target_label": "CACNA1H",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.621",
"act_comment": "HEK-293 cells stably expressing hCav3.2 T-type Ca2+ channels",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:77993",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "eletriptan targets HTR1A",
"source_label": "eletriptan",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:77993",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "eletriptan targets HTR1B",
"source_label": "eletriptan",
"target_label": "HTR1B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "GRAC: human 5-HT1B probe",
"act_source": "CHEMBL"
}
},
{
"source": "CID:77993",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "eletriptan targets HTR1D",
"source_label": "eletriptan",
"target_label": "HTR1D",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.05",
"act_comment": "GRAC: human 5-HT1D probe",
"act_source": "CHEMBL"
}
},
{
"source": "CID:77993",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "eletriptan targets HTR1E",
"source_label": "eletriptan",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:77993",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "eletriptan targets HTR1F",
"source_label": "eletriptan",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:42723",
"relation": "IDG (Drug Target)",
"target": "2261",
"properties": {
"id": "elliptinium targets FGFR3",
"source_label": "elliptinium",
"target_label": "FGFR3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Inhibitory activity against Fibroblast growth factor receptor 3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:42723",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "elliptinium targets KIT",
"source_label": "elliptinium",
"target_label": "KIT",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Inhibitory concentration against c-Kit wild type expressed in recombinant baculovirus",
"act_source": "CHEMBL"
}
},
{
"source": "CID:42723",
"relation": "IDG (Drug Target)",
"target": "5156",
"properties": {
"id": "elliptinium targets PDGFRA",
"source_label": "elliptinium",
"target_label": "PDGFRA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Inhibitory activity against Platelet-derived growth factor receptor alpha",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3219",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "emedastine targets HRH1",
"source_label": "emedastine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.886",
"act_comment": "Mechanism of Action",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:10219",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "emetine targets ADRA2A",
"source_label": "emetine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.854",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:10219",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "emetine targets ADRA2C",
"source_label": "emetine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.585",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5462501",
"relation": "IDG (Drug Target)",
"target": "1636",
"properties": {
"id": "enalaprilat targets ACE",
"source_label": "enalaprilat",
"target_label": "ACE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9978336",
"relation": "IDG (Drug Target)",
"target": "5731",
"properties": {
"id": "enprostil targets PTGER1",
"source_label": "enprostil",
"target_label": "PTGER1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9978336",
"relation": "IDG (Drug Target)",
"target": "5733",
"properties": {
"id": "enprostil targets PTGER3",
"source_label": "enprostil",
"target_label": "PTGER3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9978336",
"relation": "IDG (Drug Target)",
"target": "5734",
"properties": {
"id": "enprostil targets PTGER4",
"source_label": "enprostil",
"target_label": "PTGER4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9978336",
"relation": "IDG (Drug Target)",
"target": "5737",
"properties": {
"id": "enprostil targets PTGFR",
"source_label": "enprostil",
"target_label": "PTGFR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5281081",
"relation": "IDG (Drug Target)",
"target": "1312",
"properties": {
"id": "entacapone targets COMT",
"source_label": "entacapone",
"target_label": "COMT",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.523",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:1549120",
"relation": "IDG (Drug Target)",
"target": "231",
"properties": {
"id": "epalrestat targets AKR1B1",
"source_label": "epalrestat",
"target_label": "AKR1B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.678",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:1549120",
"relation": "IDG (Drug Target)",
"target": "57016",
"properties": {
"id": "epalrestat targets AKR1B10",
"source_label": "epalrestat",
"target_label": "AKR1B10",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Inhibition of reductase activity of N-terminal 6His-tagged AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as inhibition of NADPH linked pyridine-3-aldehyde reduction",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3236",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "eperisone targets CHRM2",
"source_label": "eperisone",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.08",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3236",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "eperisone targets SIGMAR1",
"source_label": "eperisone",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.77",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3241",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "epinastine targets HRH1",
"source_label": "epinastine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5816",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "epinephrine targets ADRA1B",
"source_label": "epinephrine",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5816",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "epinephrine targets ADRA1D",
"source_label": "epinephrine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5816",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "epinephrine targets ADRA2A",
"source_label": "epinephrine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.559",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5816",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "epinephrine targets ADRA2B",
"source_label": "epinephrine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.401",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5816",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "epinephrine targets ADRA2C",
"source_label": "epinephrine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.449",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5816",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "epinephrine targets ADRB2",
"source_label": "epinephrine",
"target_label": "ADRB2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "Binding affinity to human adrenergic beta2 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5816",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "epinephrine targets DRD2",
"source_label": "epinephrine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "Displacement of [3H]spiperone from human D2S receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:443872",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "eplerenone targets NR3C2",
"source_label": "eplerenone",
"target_label": "NR3C2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5282411",
"relation": "IDG (Drug Target)",
"target": "5739",
"properties": {
"id": "epoprostenol targets PTGIR",
"source_label": "epoprostenol",
"target_label": "PTGIR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5281037",
"relation": "IDG (Drug Target)",
"target": "185",
"properties": {
"id": "eprosartan targets AGTR1",
"source_label": "eprosartan",
"target_label": "AGTR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3250",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "ergometrine targets ADRA1B",
"source_label": "ergometrine",
"target_label": "ADRA1B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.367",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3250",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "ergometrine targets ADRA2A",
"source_label": "ergometrine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.201",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3250",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "ergometrine targets ADRA2B",
"source_label": "ergometrine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.879",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3250",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "ergometrine targets DRD2",
"source_label": "ergometrine",
"target_label": "DRD2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3250",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "ergometrine targets DRD3",
"source_label": "ergometrine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.714",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3250",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "ergometrine targets HTR1A",
"source_label": "ergometrine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.333",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3250",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "ergometrine targets HTR1D",
"source_label": "ergometrine",
"target_label": "HTR1D",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3250",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "ergometrine targets HTR1E",
"source_label": "ergometrine",
"target_label": "HTR1E",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3250",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "ergometrine targets HTR2A",
"source_label": "ergometrine",
"target_label": "HTR2A",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3250",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "ergometrine targets HTR2B",
"source_label": "ergometrine",
"target_label": "HTR2B",
"act_type": "Ki",
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"act_value": "8.58",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3250",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "ergometrine targets HTR2C",
"source_label": "ergometrine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.959",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3250",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "ergometrine targets HTR6",
"source_label": "ergometrine",
"target_label": "HTR6",
"act_type": "Ki",
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"act_value": "8.824",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:8223",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "ergotamine targets ADRA1D",
"source_label": "ergotamine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.487",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:8223",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "ergotamine targets ADRA2A",
"source_label": "ergotamine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.099",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:8223",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "ergotamine targets ADRA2B",
"source_label": "ergotamine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.754",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:8223",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "ergotamine targets ADRA2C",
"source_label": "ergotamine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.742",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:8223",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "ergotamine targets CYP3A4",
"source_label": "ergotamine",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:8223",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "ergotamine targets DRD1",
"source_label": "ergotamine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.063",
"act_comment": "DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:8223",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "ergotamine targets DRD2",
"source_label": "ergotamine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.845",
"act_comment": "DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:8223",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "ergotamine targets DRD3",
"source_label": "ergotamine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.836",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:8223",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "ergotamine targets HTR1A",
"source_label": "ergotamine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.354",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:8223",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "ergotamine targets HTR1B",
"source_label": "ergotamine",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.68",
"act_comment": "Displacement of [3H]carboxytryptamine from recombinant human 5-HT1B receptor expressed in HEK cells by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:8223",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "ergotamine targets HTR1D",
"source_label": "ergotamine",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:8223",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "ergotamine targets HTR1E",
"source_label": "ergotamine",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:8223",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "ergotamine targets HTR1F",
"source_label": "ergotamine",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:8223",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "ergotamine targets HTR2A",
"source_label": "ergotamine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:8223",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "ergotamine targets HTR2B",
"source_label": "ergotamine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:8223",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "ergotamine targets HTR2C",
"source_label": "ergotamine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:8223",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "ergotamine targets HTR5A",
"source_label": "ergotamine",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Displacement of [3H]LSD from 5-HT5A receptor after 1.5 hrs by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:8223",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "ergotamine targets HTR6",
"source_label": "ergotamine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:122173793",
"relation": "IDG (Drug Target)",
"target": "7099",
"properties": {
"id": "eritoran targets TLR4",
"source_label": "eritoran",
"target_label": "TLR4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.82",
"act_comment": "Antagonist activity at TLR4 in human serum assessed as reduction in LPS-induced TNFalpha production after 3 hrs by ELISA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "erlotinib targets ABL1",
"source_label": "erlotinib",
"target_label": "ABL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.24",
"act_comment": "Binding constant for ABL1(H396P)-phosphorylated kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "27",
"properties": {
"id": "erlotinib targets ABL2",
"source_label": "erlotinib",
"target_label": "ABL2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Binding constant for ABL2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "6795",
"properties": {
"id": "erlotinib targets AURKC",
"source_label": "erlotinib",
"target_label": "AURKC",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Binding constant for full-length AURKC",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "640",
"properties": {
"id": "erlotinib targets BLK",
"source_label": "erlotinib",
"target_label": "BLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Binding constant for BLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "673",
"properties": {
"id": "erlotinib targets BRAF",
"source_label": "erlotinib",
"target_label": "BRAF",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.22",
"act_comment": "Inhibition of recombinant full-length GST-tagged human B-RAF V600E mutant (417 to 766 residues) expressed in Baculovirus infected Sf9 cells using N-terminal His-tagged human MEK1 as substrate by Nu-page gel-based phosphor screen analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "699",
"properties": {
"id": "erlotinib targets BUB1",
"source_label": "erlotinib",
"target_label": "BUB1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.95",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "11113",
"properties": {
"id": "erlotinib targets CIT",
"source_label": "erlotinib",
"target_label": "CIT",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Binding constant for CIT kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "1454",
"properties": {
"id": "erlotinib targets CSNK1E",
"source_label": "erlotinib",
"target_label": "CSNK1E",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Binding constant for CSNK1E kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "780",
"properties": {
"id": "erlotinib targets DDR1",
"source_label": "erlotinib",
"target_label": "DDR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Binding constant for DDR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "erlotinib targets EGFR",
"source_label": "erlotinib",
"target_label": "EGFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.22",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "2044",
"properties": {
"id": "erlotinib targets EPHA5",
"source_label": "erlotinib",
"target_label": "EPHA5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Binding constant for EPHA5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "285220",
"properties": {
"id": "erlotinib targets EPHA6",
"source_label": "erlotinib",
"target_label": "EPHA6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Binding constant for EPHA6 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "2046",
"properties": {
"id": "erlotinib targets EPHA8",
"source_label": "erlotinib",
"target_label": "EPHA8",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "Binding constant for EPHA8 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "2066",
"properties": {
"id": "erlotinib targets ERBB4",
"source_label": "erlotinib",
"target_label": "ERBB4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Binding constant for ERBB4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "erlotinib targets FLT3",
"source_label": "erlotinib",
"target_label": "FLT3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Binding constant for FLT3(D835Y) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "2580",
"properties": {
"id": "erlotinib targets GAK",
"source_label": "erlotinib",
"target_label": "GAK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.51",
"act_comment": "Binding constant for GAK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "147746",
"properties": {
"id": "erlotinib targets HIPK4",
"source_label": "erlotinib",
"target_label": "HIPK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "Binding constant for HIPK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "3718",
"properties": {
"id": "erlotinib targets JAK3",
"source_label": "erlotinib",
"target_label": "JAK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Binding constant for JAK3(JH1domain-catalytic) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "erlotinib targets LCK",
"source_label": "erlotinib",
"target_label": "LCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Binding constant for LCK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "4058",
"properties": {
"id": "erlotinib targets LTK",
"source_label": "erlotinib",
"target_label": "LTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Binding constant for LTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "4067",
"properties": {
"id": "erlotinib targets LYN",
"source_label": "erlotinib",
"target_label": "LYN",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Binding constant for LYN kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "5607",
"properties": {
"id": "erlotinib targets MAP2K5",
"source_label": "erlotinib",
"target_label": "MAP2K5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.02",
"act_comment": "Binding constant for MEK5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "80122",
"properties": {
"id": "erlotinib targets MAP3K19",
"source_label": "erlotinib",
"target_label": "MAP3K19",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "Binding constant for YSK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "10461",
"properties": {
"id": "erlotinib targets MERTK",
"source_label": "erlotinib",
"target_label": "MERTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Binding constant for MERTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "8569",
"properties": {
"id": "erlotinib targets MKNK1",
"source_label": "erlotinib",
"target_label": "MKNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "Binding constant for full-length MKNK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "2872",
"properties": {
"id": "erlotinib targets MKNK2",
"source_label": "erlotinib",
"target_label": "MKNK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for MKNK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "85366",
"properties": {
"id": "erlotinib targets MYLK2",
"source_label": "erlotinib",
"target_label": "MYLK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Binding constant for MYLK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "79837",
"properties": {
"id": "erlotinib targets PIP4K2C",
"source_label": "erlotinib",
"target_label": "PIP4K2C",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for PIP5K2C kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "erlotinib targets RET",
"source_label": "erlotinib",
"target_label": "RET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Binding constant for RET(M918T) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "erlotinib targets RIPK2",
"source_label": "erlotinib",
"target_label": "RIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "Average Binding Constant for RIPK2; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "11309",
"properties": {
"id": "erlotinib targets SLCO2B1",
"source_label": "erlotinib",
"target_label": "SLCO2B1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "9748",
"properties": {
"id": "erlotinib targets SLK",
"source_label": "erlotinib",
"target_label": "SLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.59",
"act_comment": "Binding constant for SLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "6714",
"properties": {
"id": "erlotinib targets SRC",
"source_label": "erlotinib",
"target_label": "SRC",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Binding constant for SRC kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "6793",
"properties": {
"id": "erlotinib targets STK10",
"source_label": "erlotinib",
"target_label": "STK10",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "Binding constant for LOK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "7075",
"properties": {
"id": "erlotinib targets TIE1",
"source_label": "erlotinib",
"target_label": "TIE1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "Binding constant for TIE1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "8711",
"properties": {
"id": "erlotinib targets TNK1",
"source_label": "erlotinib",
"target_label": "TNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "Binding constant for full-length TNK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "51086",
"properties": {
"id": "erlotinib targets TNNI3K",
"source_label": "erlotinib",
"target_label": "TNNI3K",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Binding constant for full-length TNNI3K",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176870",
"relation": "IDG (Drug Target)",
"target": "25989",
"properties": {
"id": "erlotinib targets ULK3",
"source_label": "erlotinib",
"target_label": "ULK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "Binding constant for ULK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:12560",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "erythromycin targets KCNH2",
"source_label": "erythromycin",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.41",
"act_comment": "Inhibition of human ERG expressed in HEK cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:146570",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "escitalopram targets SLC6A4",
"source_label": "escitalopram",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.959",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:59768",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "esmolol targets ADRB1",
"source_label": "esmolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5757",
"relation": "IDG (Drug Target)",
"target": "316",
"properties": {
"id": "estradiol targets AOX1",
"source_label": "estradiol",
"target_label": "AOX1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.538",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5757",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "estradiol targets AR",
"source_label": "estradiol",
"target_label": "AR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "Inhibitory activity against AR",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5757",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "estradiol targets ESR1",
"source_label": "estradiol",
"target_label": "ESR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "10.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5757",
"relation": "IDG (Drug Target)",
"target": "2100",
"properties": {
"id": "estradiol targets ESR2",
"source_label": "estradiol",
"target_label": "ESR2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5757",
"relation": "IDG (Drug Target)",
"target": "2101",
"properties": {
"id": "estradiol targets ESRRA",
"source_label": "estradiol",
"target_label": "ESRRA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.44",
"act_comment": "Inhibition of human ERalpha",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5757",
"relation": "IDG (Drug Target)",
"target": "2103",
"properties": {
"id": "estradiol targets ESRRB",
"source_label": "estradiol",
"target_label": "ESRRB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.49",
"act_comment": "Inhibition of human ERbeta",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5757",
"relation": "IDG (Drug Target)",
"target": "2852",
"properties": {
"id": "estradiol targets GPER1",
"source_label": "estradiol",
"target_label": "GPER1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.52",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5757",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "estradiol targets SHBG",
"source_label": "estradiol",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.83",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:222757",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "estradiol benzoate targets ESR1",
"source_label": "estradiol benzoate",
"target_label": "ESR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.745",
"act_comment": "DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:9403",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "estradiol cypionate targets AR",
"source_label": "estradiol cypionate",
"target_label": "AR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "Inhibitory activity against AR",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9403",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "estradiol cypionate targets ESR1",
"source_label": "estradiol cypionate",
"target_label": "ESR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "10.74",
"act_comment": "Transcriptional potency (EC50) at Human estrogen receptor alpha",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9403",
"relation": "IDG (Drug Target)",
"target": "2100",
"properties": {
"id": "estradiol cypionate targets ESR2",
"source_label": "estradiol cypionate",
"target_label": "ESR2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "11.0",
"act_comment": "Activation of human ERbeta expressed in human U2-OS cells by luciferase reporter gene assay relative to untreated control",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9403",
"relation": "IDG (Drug Target)",
"target": "2101",
"properties": {
"id": "estradiol cypionate targets ESRRA",
"source_label": "estradiol cypionate",
"target_label": "ESRRA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.44",
"act_comment": "Inhibition of human ERalpha",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9403",
"relation": "IDG (Drug Target)",
"target": "2103",
"properties": {
"id": "estradiol cypionate targets ESRRB",
"source_label": "estradiol cypionate",
"target_label": "ESRRB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.49",
"act_comment": "Inhibition of human ERbeta",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9403",
"relation": "IDG (Drug Target)",
"target": "2852",
"properties": {
"id": "estradiol cypionate targets GPER1",
"source_label": "estradiol cypionate",
"target_label": "GPER1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.57",
"act_comment": "Competitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9403",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "estradiol cypionate targets SHBG",
"source_label": "estradiol cypionate",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.83",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10577",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "estriol succinate targets ESR1",
"source_label": "estriol succinate",
"target_label": "ESR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.32",
"act_comment": "DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10577",
"relation": "IDG (Drug Target)",
"target": "2100",
"properties": {
"id": "estriol succinate targets ESR2",
"source_label": "estriol succinate",
"target_label": "ESR2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.9",
"act_comment": "Agonist activity at ER-beta (unknown origin) transfected in HEK293T cells after 24 hrs by Steady-Glo luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10577",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "estriol succinate targets SHBG",
"source_label": "estriol succinate",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.63",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:969472",
"relation": "IDG (Drug Target)",
"target": "2554",
"properties": {
"id": "eszopiclone targets GABRA1",
"source_label": "eszopiclone",
"target_label": "GABRA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Displacement of [3H]Ro15-1788 from benzodiazepine binding site of GABAA alpha-1-beta-2-gamma-2 receptor expressed in HEK293T cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:969472",
"relation": "IDG (Drug Target)",
"target": "2555",
"properties": {
"id": "eszopiclone targets GABRA2",
"source_label": "eszopiclone",
"target_label": "GABRA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.94",
"act_comment": "Displacement of [3H]Ro-151788 from benzodiazepine binding site of GABAA alpha-2-beta-2-gamma-2 receptor expressed in HEK293T cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:969472",
"relation": "IDG (Drug Target)",
"target": "2556",
"properties": {
"id": "eszopiclone targets GABRA3",
"source_label": "eszopiclone",
"target_label": "GABRA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.79",
"act_comment": "Displacement of [3H]Ro-151788 from benzodiazepine binding site of GABAA alpha-3-beta-2-gamma-2 receptor expressed in HEK293T cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:969472",
"relation": "IDG (Drug Target)",
"target": "2557",
"properties": {
"id": "eszopiclone targets GABRA4",
"source_label": "eszopiclone",
"target_label": "GABRA4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.99",
"act_comment": "Displacement of [3H]Ro-154513 from benzodiazepine binding site of GABAA alpha-4-beta-2-gamma-2 receptor expressed in HEK293T cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:470071",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "ethambutol targets CYP3A4",
"source_label": "ethambutol",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5991",
"relation": "IDG (Drug Target)",
"target": "316",
"properties": {
"id": "ethinylestradiol targets AOX1",
"source_label": "ethinylestradiol",
"target_label": "AOX1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.244",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5991",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "ethinylestradiol targets AR",
"source_label": "ethinylestradiol",
"target_label": "AR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5991",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "ethinylestradiol targets ESR1",
"source_label": "ethinylestradiol",
"target_label": "ESR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.83",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5991",
"relation": "IDG (Drug Target)",
"target": "2100",
"properties": {
"id": "ethinylestradiol targets ESR2",
"source_label": "ethinylestradiol",
"target_label": "ESR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.09",
"act_comment": "Binding affinity to ERbeta",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5991",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "ethinylestradiol targets NR3C1",
"source_label": "ethinylestradiol",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5991",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "ethinylestradiol targets SHBG",
"source_label": "ethinylestradiol",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.81",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5991",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "ethinylestradiol targets SLC6A2",
"source_label": "ethinylestradiol",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.022",
"act_comment": "DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5991",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "ethinylestradiol targets SLC6A3",
"source_label": "ethinylestradiol",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.353",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5991",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "ethinylestradiol targets SLC6A4",
"source_label": "ethinylestradiol",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.538",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:7061041",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "ethisterone targets NR3C1",
"source_label": "ethisterone",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.022",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:7061041",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "ethisterone targets SHBG",
"source_label": "ethisterone",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.78",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3290",
"relation": "IDG (Drug Target)",
"target": "590",
"properties": {
"id": "profenamine targets BCHE",
"source_label": "profenamine",
"target_label": "BCHE",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Inhibitory activity against Equine Butyrylcholinesterase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3295",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "ethoxzolamide targets CA1",
"source_label": "ethoxzolamide",
"target_label": "CA1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3295",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "ethoxzolamide targets CA12",
"source_label": "ethoxzolamide",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.66",
"act_comment": "Ki value against human carbonic anhydrase XII (hCA XII)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3295",
"relation": "IDG (Drug Target)",
"target": "377677",
"properties": {
"id": "ethoxzolamide targets CA13",
"source_label": "ethoxzolamide",
"target_label": "CA13",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Binding affinity to human recombinant CA13 at 37 degC and pH 7.0 by thermal shift assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3295",
"relation": "IDG (Drug Target)",
"target": "23632",
"properties": {
"id": "ethoxzolamide targets CA14",
"source_label": "ethoxzolamide",
"target_label": "CA14",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.6",
"act_comment": "Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3295",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "ethoxzolamide targets CA2",
"source_label": "ethoxzolamide",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.31",
"act_comment": "In vitro binding to human erythrocyte carbonic anhydrase was determined by fluorescence competition assay employing the fluorescent CA inhibitor dansylamide",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3295",
"relation": "IDG (Drug Target)",
"target": "762",
"properties": {
"id": "ethoxzolamide targets CA4",
"source_label": "ethoxzolamide",
"target_label": "CA4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.03",
"act_comment": "Inhibitory activity against human carbonic anhydrase IV (hCAIV)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3295",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "ethoxzolamide targets CA5A",
"source_label": "ethoxzolamide",
"target_label": "CA5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "Inhibitory activity against human recombinant mitochondrial isozyme CA VA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3295",
"relation": "IDG (Drug Target)",
"target": "11238",
"properties": {
"id": "ethoxzolamide targets CA5B",
"source_label": "ethoxzolamide",
"target_label": "CA5B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "Inhibitory activity against human recombinant mitochondrial isozyme CA VB",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3295",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "ethoxzolamide targets CA6",
"source_label": "ethoxzolamide",
"target_label": "CA6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.48",
"act_comment": "Binding affinity to human recombinant carbonic anhydrase 6 expressed in Escherichia coli Rosetta2 (DE3) by thermal shift assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3295",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "ethoxzolamide targets CA7",
"source_label": "ethoxzolamide",
"target_label": "CA7",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.15",
"act_comment": "Binding affinity to human recombinant CA7 at 37 degC and pH 7.0 by thermal shift assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3295",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "ethoxzolamide targets CA9",
"source_label": "ethoxzolamide",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.47",
"act_comment": "Inhibitory activity against human tumor-associated transmembrane carbonic anhydrase IX.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:13765",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "ethylestrenol targets CHRM2",
"source_label": "ethylestrenol",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.983",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:13765",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "ethylestrenol targets ESR1",
"source_label": "ethylestrenol",
"target_label": "ESR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.495",
"act_comment": "DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:13765",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "ethylestrenol targets SLC6A4",
"source_label": "ethylestrenol",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.367",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:9982",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "etilamfetamine targets SIGMAR1",
"source_label": "etilamfetamine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.18",
"act_comment": "Binding affinity towards sigma opioid receptor in guinea pig cerebral homogenate using [3H]DTG as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:667484",
"relation": "IDG (Drug Target)",
"target": "1584",
"properties": {
"id": "etomidate targets CYP11B1",
"source_label": "etomidate",
"target_label": "CYP11B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "Inhibition of human CYP11B1 expressed in chinese hamster V79 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:667484",
"relation": "IDG (Drug Target)",
"target": "1585",
"properties": {
"id": "etomidate targets CYP11B2",
"source_label": "etomidate",
"target_label": "CYP11B2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.0",
"act_comment": "Inhibition of human CYP11B2 expressed in hamster V79MZ cells using 11-deoxycorticosterone substrate",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6917715",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "etonogestrel targets SHBG",
"source_label": "etonogestrel",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.23",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:40589",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "etoperidone targets HTR1A",
"source_label": "etoperidone",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.071",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:40589",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "etoperidone targets SLC6A4",
"source_label": "etoperidone",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.051",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:36462",
"relation": "IDG (Drug Target)",
"target": "7153",
"properties": {
"id": "etoposide targets TOP2A",
"source_label": "etoposide",
"target_label": "TOP2A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Note: enzyme subunit is not specified in the referenced article",
"act_source": "IUPHAR"
}
},
{
"source": "CID:36462",
"relation": "IDG (Drug Target)",
"target": "7155",
"properties": {
"id": "etoposide targets TOP2B",
"source_label": "etoposide",
"target_label": "TOP2B",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.16",
"act_comment": "Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123619",
"relation": "IDG (Drug Target)",
"target": "1432",
"properties": {
"id": "etoricoxib targets MAPK14",
"source_label": "etoricoxib",
"target_label": "MAPK14",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Inhibitory concentration against p38 alpha MAP kinase calculated by CoMFA model; FlexX score = -18.6kcal/mol ",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123619",
"relation": "IDG (Drug Target)",
"target": "5732",
"properties": {
"id": "etoricoxib targets PTGER2",
"source_label": "etoricoxib",
"target_label": "PTGER2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.102",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:123619",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "etoricoxib targets PTGS2",
"source_label": "etoricoxib",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6442177",
"relation": "IDG (Drug Target)",
"target": "2280",
"properties": {
"id": "everolimus targets FKBP1A",
"source_label": "everolimus",
"target_label": "FKBP1A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.26",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6442177",
"relation": "IDG (Drug Target)",
"target": "2475",
"properties": {
"id": "everolimus targets MTOR",
"source_label": "everolimus",
"target_label": "MTOR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:16157882",
"relation": "IDG (Drug Target)",
"target": "2740",
"properties": {
"id": "exenatide targets GLP1R",
"source_label": "exenatide",
"target_label": "GLP1R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.18",
"act_comment": "Displacement of [125I]GLP1 from human GLP1R expressed in CHOK1 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:150311",
"relation": "IDG (Drug Target)",
"target": "29881",
"properties": {
"id": "ezetimibe targets NPC1L1",
"source_label": "ezetimibe",
"target_label": "NPC1L1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Measure of ezetimibe glucuronide binding to NPC1L1",
"act_source": "IUPHAR"
}
},
{
"source": "CID:59693",
"relation": "IDG (Drug Target)",
"target": "1584",
"properties": {
"id": "fadrozole targets CYP11B1",
"source_label": "fadrozole",
"target_label": "CYP11B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "Inhibition of human CYP11B1 expressed in V79MZh cells using [14C]-11-deoxycorticosterone as substrate by HPTLC/phosphoimaging method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:59693",
"relation": "IDG (Drug Target)",
"target": "1585",
"properties": {
"id": "fadrozole targets CYP11B2",
"source_label": "fadrozole",
"target_label": "CYP11B2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "Inhibition of human CYP11B2 expressed in V79MZh cells using [14C]-11-deoxycorticosterone as substrate by HPTLC/phosphoimaging method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:59693",
"relation": "IDG (Drug Target)",
"target": "1588",
"properties": {
"id": "fadrozole targets CYP19A1",
"source_label": "fadrozole",
"target_label": "CYP19A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.3",
"act_comment": "Competitive inhibition of human aromatase using dibenzylfluorescein substrate after 10 mins preincubation measured every 10 sec for 5 mins by Michaelis-Menten and Dixon plot analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3325",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "famotidine targets CA1",
"source_label": "famotidine",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "Inhibition of recombinant human CA1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3325",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "famotidine targets CA12",
"source_label": "famotidine",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.34",
"act_comment": "Inhibition of recombinant human CA12 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3325",
"relation": "IDG (Drug Target)",
"target": "377677",
"properties": {
"id": "famotidine targets CA13",
"source_label": "famotidine",
"target_label": "CA13",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Inhibition of recombinant human CA13 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3325",
"relation": "IDG (Drug Target)",
"target": "23632",
"properties": {
"id": "famotidine targets CA14",
"source_label": "famotidine",
"target_label": "CA14",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Inhibition of recombinant human CA14 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3325",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "famotidine targets CA2",
"source_label": "famotidine",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.24",
"act_comment": "Inhibition of recombinant human CA2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3325",
"relation": "IDG (Drug Target)",
"target": "762",
"properties": {
"id": "famotidine targets CA4",
"source_label": "famotidine",
"target_label": "CA4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "Inhibition of recombinant human CA4 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3325",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "famotidine targets CA6",
"source_label": "famotidine",
"target_label": "CA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.01",
"act_comment": "Inhibition of recombinant human CA6 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3325",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "famotidine targets CA7",
"source_label": "famotidine",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "Inhibition of recombinant human CA7 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3325",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "famotidine targets CA9",
"source_label": "famotidine",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "Inhibition of recombinant human CA9 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3325",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "famotidine targets HRH2",
"source_label": "famotidine",
"target_label": "HRH2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.93",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3325",
"relation": "IDG (Drug Target)",
"target": "55244",
"properties": {
"id": "famotidine targets SLC47A1",
"source_label": "famotidine",
"target_label": "SLC47A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3547",
"relation": "IDG (Drug Target)",
"target": "1195",
"properties": {
"id": "fasudil targets CLK1",
"source_label": "fasudil",
"target_label": "CLK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3547",
"relation": "IDG (Drug Target)",
"target": "5586",
"properties": {
"id": "fasudil targets PKN2",
"source_label": "fasudil",
"target_label": "PKN2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Inhibition of PKN2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3547",
"relation": "IDG (Drug Target)",
"target": "29941",
"properties": {
"id": "fasudil targets PKN3",
"source_label": "fasudil",
"target_label": "PKN3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3547",
"relation": "IDG (Drug Target)",
"target": "6093",
"properties": {
"id": "fasudil targets ROCK1",
"source_label": "fasudil",
"target_label": "ROCK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Inhibition of ROCK-1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3547",
"relation": "IDG (Drug Target)",
"target": "9475",
"properties": {
"id": "fasudil targets ROCK2",
"source_label": "fasudil",
"target_label": "ROCK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.11",
"act_comment": "Displacement of fluorescent-ARC-1063 from His6-tagged recombinant human ROCK2 by luminescence intensity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:134018",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "febuxostat targets KCNH2",
"source_label": "febuxostat",
"target_label": "KCNH2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.44",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134018",
"relation": "IDG (Drug Target)",
"target": "7498",
"properties": {
"id": "febuxostat targets XDH",
"source_label": "febuxostat",
"target_label": "XDH",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.22",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3332",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "felbinac targets PTGS1",
"source_label": "felbinac",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.049",
"act_comment": "DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3333",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "felodipine targets ADORA3",
"source_label": "felodipine",
"target_label": "ADORA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.224",
"act_comment": "DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3333",
"relation": "IDG (Drug Target)",
"target": "316",
"properties": {
"id": "felodipine targets AOX1",
"source_label": "felodipine",
"target_label": "AOX1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.523",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3333",
"relation": "IDG (Drug Target)",
"target": "1080",
"properties": {
"id": "felodipine targets CFTR",
"source_label": "felodipine",
"target_label": "CFTR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3336",
"relation": "IDG (Drug Target)",
"target": "846",
"properties": {
"id": "fendiline targets CASR",
"source_label": "fendiline",
"target_label": "CASR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Positive allosteric modulation of human CaSR transfected in CHO cells after 5 hrs by luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3339",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "fenofibrate targets HTR2A",
"source_label": "fenofibrate",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.218",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3339",
"relation": "IDG (Drug Target)",
"target": "5465",
"properties": {
"id": "fenofibrate targets PPARA",
"source_label": "fenofibrate",
"target_label": "PPARA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Inhibition of human PPARalpha receptor by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3339",
"relation": "IDG (Drug Target)",
"target": "5468",
"properties": {
"id": "fenofibrate targets PPARG",
"source_label": "fenofibrate",
"target_label": "PPARG",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "In vitro activation of human peroxisome proliferator activated receptor gamma (PPAR gamma)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3341",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "fenoldopam targets DRD1",
"source_label": "fenoldopam",
"target_label": "DRD1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.55",
"act_comment": "Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3341",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "fenoldopam targets DRD2",
"source_label": "fenoldopam",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Affinity towards Dopamine receptor D2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3341",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "fenoldopam targets DRD4",
"source_label": "fenoldopam",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3341",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "fenoldopam targets DRD5",
"source_label": "fenoldopam",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3343",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "fenoterol targets ADRB2",
"source_label": "fenoterol",
"target_label": "ADRB2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3345",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "fentanyl targets OPRD1",
"source_label": "fentanyl",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Binding affinity against Opioid receptor delta 1 in guinea pig brain membranes",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3345",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "fentanyl targets OPRK1",
"source_label": "fentanyl",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.71",
"act_comment": "Binding affinity against Opioid receptor kappa 1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3345",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "fentanyl targets OPRM1",
"source_label": "fentanyl",
"target_label": "OPRM1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.001",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3345",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "fentanyl targets SIGMAR1",
"source_label": "fentanyl",
"target_label": "SIGMAR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.45",
"act_comment": "Displacement of [3H]PPP from sigma1 receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:28871",
"relation": "IDG (Drug Target)",
"target": "11251",
"properties": {
"id": "fentiazac targets PTGDR2",
"source_label": "fentiazac",
"target_label": "PTGDR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3348",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "fexofenadine targets HRH1",
"source_label": "fexofenadine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:57363",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "finasteride targets CYP2C19",
"source_label": "finasteride",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:57363",
"relation": "IDG (Drug Target)",
"target": "6715",
"properties": {
"id": "finasteride targets SRD5A1",
"source_label": "finasteride",
"target_label": "SRD5A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.58",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:57363",
"relation": "IDG (Drug Target)",
"target": "6716",
"properties": {
"id": "finasteride targets SRD5A2",
"source_label": "finasteride",
"target_label": "SRD5A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.26",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3360",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "floctafenine targets PTGS1",
"source_label": "floctafenine",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.268",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:21319",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "floxacillin targets AR",
"source_label": "floxacillin",
"target_label": "AR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:30751",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "fludarabine phosphate targets CA5A",
"source_label": "fludarabine phosphate",
"target_label": "CA5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.88",
"act_comment": "Inhibition of recombinant human carbonic anhydrase VA preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:30751",
"relation": "IDG (Drug Target)",
"target": "6240",
"properties": {
"id": "fludarabine phosphate targets RRM1",
"source_label": "fludarabine phosphate",
"target_label": "RRM1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Inhibition of ADP reduction by ribonucleotide reductase from HeLa cells",
"act_source": "IUPHAR"
}
},
{
"source": "CID:30751",
"relation": "IDG (Drug Target)",
"target": "6241",
"properties": {
"id": "fludarabine phosphate targets RRM2",
"source_label": "fludarabine phosphate",
"target_label": "RRM2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Inhibition of ADP reduction by ribonucleotide reductase from HeLa cells",
"act_source": "IUPHAR"
}
},
{
"source": "CID:225609",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "fludrocortisone acetate targets NR3C1",
"source_label": "fludrocortisone acetate",
"target_label": "NR3C1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:225609",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "fludrocortisone acetate targets NR3C2",
"source_label": "fludrocortisone acetate",
"target_label": "NR3C2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.92",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3371",
"relation": "IDG (Drug Target)",
"target": "57016",
"properties": {
"id": "flufenamic acid targets AKR1B10",
"source_label": "flufenamic acid",
"target_label": "AKR1B10",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3371",
"relation": "IDG (Drug Target)",
"target": "1646",
"properties": {
"id": "flufenamic acid targets AKR1C2",
"source_label": "flufenamic acid",
"target_label": "AKR1C2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3371",
"relation": "IDG (Drug Target)",
"target": "8644",
"properties": {
"id": "flufenamic acid targets AKR1C3",
"source_label": "flufenamic acid",
"target_label": "AKR1C3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3371",
"relation": "IDG (Drug Target)",
"target": "343450",
"properties": {
"id": "flufenamic acid targets KCNT2",
"source_label": "flufenamic acid",
"target_label": "KCNT2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.85",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3371",
"relation": "IDG (Drug Target)",
"target": "93100",
"properties": {
"id": "flufenamic acid targets NAPRT",
"source_label": "flufenamic acid",
"target_label": "NAPRT",
"act_type": "Ki",
"act_relation": "=",
"act_value": "11.0",
"act_comment": "Inhibition of NAPRT (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3371",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "flufenamic acid targets PTGS2",
"source_label": "flufenamic acid",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.93",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3371",
"relation": "IDG (Drug Target)",
"target": "50840",
"properties": {
"id": "flufenamic acid targets TAS2R14",
"source_label": "flufenamic acid",
"target_label": "TAS2R14",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.863",
"act_comment": "calcium imaging in ransfected human embryonic kidney (HEK)-293T",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:3371",
"relation": "IDG (Drug Target)",
"target": "7276",
"properties": {
"id": "flufenamic acid targets TTR",
"source_label": "flufenamic acid",
"target_label": "TTR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.25",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3373",
"relation": "IDG (Drug Target)",
"target": "2554",
"properties": {
"id": "flumazenil targets GABRA1",
"source_label": "flumazenil",
"target_label": "GABRA1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "Binding affinity to GABAA alpha-1-beta-2-gamma-2 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3373",
"relation": "IDG (Drug Target)",
"target": "2555",
"properties": {
"id": "flumazenil targets GABRA2",
"source_label": "flumazenil",
"target_label": "GABRA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.24",
"act_comment": "Displacement of [3H]Ro-151788 from benzodiazepine binding site of GABAA alpha-2-beta-2-gamma-2 receptor expressed in HEK293T cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3373",
"relation": "IDG (Drug Target)",
"target": "2556",
"properties": {
"id": "flumazenil targets GABRA3",
"source_label": "flumazenil",
"target_label": "GABRA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.09",
"act_comment": "Displacement of [3H]Ro-151788 from benzodiazepine binding site of GABAA alpha-3-beta-2-gamma-2 receptor expressed in HEK293T cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3373",
"relation": "IDG (Drug Target)",
"target": "2557",
"properties": {
"id": "flumazenil targets GABRA4",
"source_label": "flumazenil",
"target_label": "GABRA4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "Displacement of [3H]Ro-154513 from benzodiazepine binding site of GABAA alpha-4-beta-2-gamma-2 receptor expressed in HEK293T cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3373",
"relation": "IDG (Drug Target)",
"target": "2558",
"properties": {
"id": "flumazenil targets GABRA5",
"source_label": "flumazenil",
"target_label": "GABRA5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "Binding affinity to GABAA alpha-5-beta-2-gamma-2 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "flunarizine targets ADRA1D",
"source_label": "flunarizine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.357",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "flunarizine targets ADRA2A",
"source_label": "flunarizine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.662",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "flunarizine targets ADRA2B",
"source_label": "flunarizine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.063",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "flunarizine targets ADRA2C",
"source_label": "flunarizine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.495",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "8913",
"properties": {
"id": "flunarizine targets CACNA1G",
"source_label": "flunarizine",
"target_label": "CACNA1G",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Inhibition of T-type Cav3.1 channel",
"act_source": "CHEMBL"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "8911",
"properties": {
"id": "flunarizine targets CACNA1I",
"source_label": "flunarizine",
"target_label": "CACNA1I",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.08",
"act_comment": "Inhibition of T-type Cav3.3 channel",
"act_source": "CHEMBL"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "flunarizine targets CHRM1",
"source_label": "flunarizine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.151",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "flunarizine targets CHRM3",
"source_label": "flunarizine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.504",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "flunarizine targets CHRM4",
"source_label": "flunarizine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.103",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "flunarizine targets CHRM5",
"source_label": "flunarizine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "flunarizine targets DRD2",
"source_label": "flunarizine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.932",
"act_comment": "DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "flunarizine targets DRD3",
"source_label": "flunarizine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.481",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "flunarizine targets HRH1",
"source_label": "flunarizine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.745",
"act_comment": "DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "flunarizine targets HTR2A",
"source_label": "flunarizine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.936",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "flunarizine targets HTR2B",
"source_label": "flunarizine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "flunarizine targets HTR2C",
"source_label": "flunarizine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.455",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "flunarizine targets KCNH2",
"source_label": "flunarizine",
"target_label": "KCNH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.304",
"act_comment": "DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "6323",
"properties": {
"id": "flunarizine targets SCN1A",
"source_label": "flunarizine",
"target_label": "SCN1A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "flunarizine targets SIGMAR1",
"source_label": "flunarizine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "flunarizine targets SLC6A3",
"source_label": "flunarizine",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.333",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:941361",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "flunarizine targets SLC6A4",
"source_label": "flunarizine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.577",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:23236067",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "flunisolide targets NR3C1",
"source_label": "flunisolide",
"target_label": "NR3C1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3380",
"relation": "IDG (Drug Target)",
"target": "2554",
"properties": {
"id": "flunitrazepam targets GABRA1",
"source_label": "flunitrazepam",
"target_label": "GABRA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.28",
"act_comment": "Assay using recombinant GABAA channels with subunit composition; α1β3γ2.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3380",
"relation": "IDG (Drug Target)",
"target": "2555",
"properties": {
"id": "flunitrazepam targets GABRA2",
"source_label": "flunitrazepam",
"target_label": "GABRA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.28",
"act_comment": "Assay using recombinant GABAA channels with subunit composition; α2β1γ2.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3380",
"relation": "IDG (Drug Target)",
"target": "2556",
"properties": {
"id": "flunitrazepam targets GABRA3",
"source_label": "flunitrazepam",
"target_label": "GABRA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "Assay using recombinant GABAA channels with subunit composition; α3β1γ2.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3380",
"relation": "IDG (Drug Target)",
"target": "2558",
"properties": {
"id": "flunitrazepam targets GABRA5",
"source_label": "flunitrazepam",
"target_label": "GABRA5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.26",
"act_comment": "Assay using recombinant GABAA channels with subunit composition; α5β1γ2.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6215",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "fluocinolone acetonide targets NR3C1",
"source_label": "fluocinolone acetonide",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.848",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:9642",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "fluocinonide targets NR3C1",
"source_label": "fluocinonide",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.622",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:9878",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "fluorometholone targets NR3C1",
"source_label": "fluorometholone",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.801",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3386",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "fluoxetine targets ACHE",
"source_label": "fluoxetine",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Inhibition of AChE",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3386",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "fluoxetine targets ADRA2A",
"source_label": "fluoxetine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3386",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "fluoxetine targets ADRA2B",
"source_label": "fluoxetine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.156",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3386",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "fluoxetine targets CHRM1",
"source_label": "fluoxetine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.047",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3386",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "fluoxetine targets CHRM3",
"source_label": "fluoxetine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3386",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "fluoxetine targets CYP2D6",
"source_label": "fluoxetine",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.155",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3386",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "fluoxetine targets HTR2A",
"source_label": "fluoxetine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.61",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3386",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "fluoxetine targets HTR2C",
"source_label": "fluoxetine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3386",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "fluoxetine targets HTR6",
"source_label": "fluoxetine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3386",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "fluoxetine targets KCNH2",
"source_label": "fluoxetine",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.155",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3386",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "fluoxetine targets SIGMAR1",
"source_label": "fluoxetine",
"target_label": "SIGMAR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "The compound was tested for affinity towards sigma-3 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3386",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "fluoxetine targets SLC6A2",
"source_label": "fluoxetine",
"target_label": "SLC6A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3386",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "fluoxetine targets SLC6A4",
"source_label": "fluoxetine",
"target_label": "SLC6A4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.091",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6446",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "fluoxymesterone targets AR",
"source_label": "fluoxymesterone",
"target_label": "AR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.24",
"act_comment": "Displacement of [3H]DHT from human AR expressed in MDA-MB-453 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5281881",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "flupentixol targets DRD1",
"source_label": "flupentixol",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "Note that this assay uses the cis form of the compound, whereas the approved drug is a racemic mixture of cis and trans molecules.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5281881",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "flupentixol targets DRD2",
"source_label": "flupentixol",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.82",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5281881",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "flupentixol targets DRD3",
"source_label": "flupentixol",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.96",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5281881",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "flupentixol targets DRD5",
"source_label": "flupentixol",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5281881",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "flupentixol targets SIGMAR1",
"source_label": "flupentixol",
"target_label": "SIGMAR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.65",
"act_comment": "The compound was tested for affinity towards sigma-3 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "fluphenazine targets ADRA1A",
"source_label": "fluphenazine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.191",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "fluphenazine targets ADRA1B",
"source_label": "fluphenazine",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.886",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "fluphenazine targets ADRA1D",
"source_label": "fluphenazine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.019",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "fluphenazine targets ADRA2A",
"source_label": "fluphenazine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.503",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "fluphenazine targets ADRA2B",
"source_label": "fluphenazine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.087",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "fluphenazine targets ADRA2C",
"source_label": "fluphenazine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.539",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "fluphenazine targets CHRM1",
"source_label": "fluphenazine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "fluphenazine targets CHRM4",
"source_label": "fluphenazine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.315",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "fluphenazine targets CHRM5",
"source_label": "fluphenazine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.447",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "fluphenazine targets DRD1",
"source_label": "fluphenazine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.649",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "fluphenazine targets DRD2",
"source_label": "fluphenazine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.269",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "fluphenazine targets DRD3",
"source_label": "fluphenazine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.37",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "fluphenazine targets DRD4",
"source_label": "fluphenazine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.535",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "fluphenazine targets DRD5",
"source_label": "fluphenazine",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.887",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "fluphenazine targets HRH1",
"source_label": "fluphenazine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.793",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "fluphenazine targets HRH2",
"source_label": "fluphenazine",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.252",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "fluphenazine targets HTR1A",
"source_label": "fluphenazine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.838",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "fluphenazine targets HTR1B",
"source_label": "fluphenazine",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.476",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "fluphenazine targets HTR1D",
"source_label": "fluphenazine",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.476",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "fluphenazine targets HTR1E",
"source_label": "fluphenazine",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.268",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "fluphenazine targets HTR2A",
"source_label": "fluphenazine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.044",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "fluphenazine targets HTR2B",
"source_label": "fluphenazine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.602",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "fluphenazine targets HTR2C",
"source_label": "fluphenazine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.456",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "fluphenazine targets HTR5A",
"source_label": "fluphenazine",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.839",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "fluphenazine targets HTR6",
"source_label": "fluphenazine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.464",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "fluphenazine targets HTR7",
"source_label": "fluphenazine",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.097",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "fluphenazine targets SIGMAR1",
"source_label": "fluphenazine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.067",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:134141",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "fluphenazine targets SLC6A4",
"source_label": "fluphenazine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.101",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "fluphenazine enanthate targets ADRA1A",
"source_label": "fluphenazine enanthate",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.19",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "fluphenazine enanthate targets ADRA1B",
"source_label": "fluphenazine enanthate",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.886",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "fluphenazine enanthate targets ADRA2A",
"source_label": "fluphenazine enanthate",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.503",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "fluphenazine enanthate targets ADRA2B",
"source_label": "fluphenazine enanthate",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.087",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "fluphenazine enanthate targets ADRA2C",
"source_label": "fluphenazine enanthate",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.539",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "fluphenazine enanthate targets CHRM5",
"source_label": "fluphenazine enanthate",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.447",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "fluphenazine enanthate targets DRD1",
"source_label": "fluphenazine enanthate",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.678",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "fluphenazine enanthate targets DRD2",
"source_label": "fluphenazine enanthate",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.268",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "fluphenazine enanthate targets DRD3",
"source_label": "fluphenazine enanthate",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.611",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "fluphenazine enanthate targets DRD4",
"source_label": "fluphenazine enanthate",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.444",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "fluphenazine enanthate targets DRD5",
"source_label": "fluphenazine enanthate",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.887",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "fluphenazine enanthate targets HRH1",
"source_label": "fluphenazine enanthate",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.68",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "fluphenazine enanthate targets HRH2",
"source_label": "fluphenazine enanthate",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.252",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "fluphenazine enanthate targets HTR1A",
"source_label": "fluphenazine enanthate",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.837",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "fluphenazine enanthate targets HTR1B",
"source_label": "fluphenazine enanthate",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.476",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "fluphenazine enanthate targets HTR1D",
"source_label": "fluphenazine enanthate",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.476",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "fluphenazine enanthate targets HTR1E",
"source_label": "fluphenazine enanthate",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.268",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "fluphenazine enanthate targets HTR2A",
"source_label": "fluphenazine enanthate",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.979",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "fluphenazine enanthate targets HTR2C",
"source_label": "fluphenazine enanthate",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.048",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "fluphenazine enanthate targets HTR5A",
"source_label": "fluphenazine enanthate",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.839",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "fluphenazine enanthate targets HTR6",
"source_label": "fluphenazine enanthate",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3389",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "fluphenazine enanthate targets HTR7",
"source_label": "fluphenazine enanthate",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.097",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:53276",
"relation": "IDG (Drug Target)",
"target": "6472",
"properties": {
"id": "flupirtine targets SHMT2",
"source_label": "flupirtine",
"target_label": "SHMT2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "Inhibition of His-tagged human recombinant SHMT2 expressed in Escherichia coli BLR(DE3) assessed as reduction in NADPH level using L-serine, THF and NADP+ incubated for 5 mins by SHMT2-MTHFD coupled reaction based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:15209",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "fludroxycortide targets NR3C1",
"source_label": "fludroxycortide",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.695",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3394",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "flurbiprofen targets PTGS1",
"source_label": "flurbiprofen",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.74",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3394",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "flurbiprofen targets PTGS2",
"source_label": "flurbiprofen",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.39",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3396",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "fluspirilene targets ADRA2A",
"source_label": "fluspirilene",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.244",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3396",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "fluspirilene targets ADRA2B",
"source_label": "fluspirilene",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.319",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3396",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "fluspirilene targets ADRA2C",
"source_label": "fluspirilene",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.208",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3396",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "fluspirilene targets ADRB1",
"source_label": "fluspirilene",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.229",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3396",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "fluspirilene targets ADRB2",
"source_label": "fluspirilene",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.292",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3396",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "fluspirilene targets DRD2",
"source_label": "fluspirilene",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.436",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3396",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "fluspirilene targets DRD3",
"source_label": "fluspirilene",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.409",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3396",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "fluspirilene targets DRD4",
"source_label": "fluspirilene",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.056",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3396",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "fluspirilene targets HRH1",
"source_label": "fluspirilene",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3396",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "fluspirilene targets HTR1A",
"source_label": "fluspirilene",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3396",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "fluspirilene targets HTR1D",
"source_label": "fluspirilene",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3396",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "fluspirilene targets HTR2A",
"source_label": "fluspirilene",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3396",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "fluspirilene targets HTR2B",
"source_label": "fluspirilene",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3396",
"relation": "IDG (Drug Target)",
"target": "4987",
"properties": {
"id": "fluspirilene targets OPRL1",
"source_label": "fluspirilene",
"target_label": "OPRL1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Displacement of [125I]nociceptin from human NOP expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:444036",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "fluticasone propionate targets NR3C1",
"source_label": "fluticasone propionate",
"target_label": "NR3C1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "10.74",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:444036",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "fluticasone propionate targets NR3C2",
"source_label": "fluticasone propionate",
"target_label": "NR3C2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.83",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:444036",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "fluticasone propionate targets PGR",
"source_label": "fluticasone propionate",
"target_label": "PGR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.77",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:446155",
"relation": "IDG (Drug Target)",
"target": "1559",
"properties": {
"id": "fluvastatin targets CYP2C9",
"source_label": "fluvastatin",
"target_label": "CYP2C9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.398",
"act_comment": "DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:446155",
"relation": "IDG (Drug Target)",
"target": "3156",
"properties": {
"id": "fluvastatin targets HMGCR",
"source_label": "fluvastatin",
"target_label": "HMGCR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.55",
"act_comment": "Inhibitory concentration against 3-hydroxy-3-methylglutaryl-CoA reductase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5324346",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "fluvoxamine targets SIGMAR1",
"source_label": "fluvoxamine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.44",
"act_comment": "Binding affinity to sigma 1 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5324346",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "fluvoxamine targets SLC6A3",
"source_label": "fluvoxamine",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.84",
"act_comment": "In vitro competitive binding versus [N-methyl-3H]WIN-35428 in murine kidney cells transfected with cDNA for human dopamine transporter (DAT)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5324346",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "fluvoxamine targets SLC6A4",
"source_label": "fluvoxamine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.51",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5282448",
"relation": "IDG (Drug Target)",
"target": "462",
"properties": {
"id": "fondaparinux targets SERPINC1",
"source_label": "fondaparinux",
"target_label": "SERPINC1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.49",
"act_comment": "Catalyses the inactivation of coagulation proteases by activated antithrombin-III",
"act_source": "IUPHAR"
}
},
{
"source": "CID:44511091",
"relation": "IDG (Drug Target)",
"target": "1588",
"properties": {
"id": "formestane targets CYP19A1",
"source_label": "formestane",
"target_label": "CYP19A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.569",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3034756",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "formoterol targets ADRB1",
"source_label": "formoterol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "Displacement of [3H]CGP12177 from human beta-1 adrenoceptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3034756",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "formoterol targets ADRB2",
"source_label": "formoterol",
"target_label": "ADRB2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.6",
"act_comment": "Binding affinity to beta-2 adrenergic receptor (unknown origin) at 1 to 10000 nM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3034756",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "formoterol targets ADRB3",
"source_label": "formoterol",
"target_label": "ADRB3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "Agonist activity at human recombinant beta3 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3034756",
"relation": "IDG (Drug Target)",
"target": "3320",
"properties": {
"id": "formoterol targets HSP90AA1",
"source_label": "formoterol",
"target_label": "HSP90AA1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.523",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9601226",
"relation": "IDG (Drug Target)",
"target": "1636",
"properties": {
"id": "fosinopril targets ACE",
"source_label": "fosinopril",
"target_label": "ACE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "Inhibitory activity against angiotensin I converting enzyme (ACE)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:77992",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "frovatriptan targets HTR1A",
"source_label": "frovatriptan",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.21",
"act_comment": "In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:77992",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "frovatriptan targets HTR1B",
"source_label": "frovatriptan",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.99",
"act_comment": "In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:77992",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "frovatriptan targets HTR1D",
"source_label": "frovatriptan",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.36",
"act_comment": "In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:135412163",
"relation": "IDG (Drug Target)",
"target": "4353",
"properties": {
"id": "ftivazide targets MPO",
"source_label": "ftivazide",
"target_label": "MPO",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.34",
"act_comment": "Inhibition of human MPO",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3478439",
"relation": "IDG (Drug Target)",
"target": "2053",
"properties": {
"id": "fulvestrant targets EPHX2",
"source_label": "fulvestrant",
"target_label": "EPHX2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.59",
"act_comment": "Competitive inhibition of human recombinant soluble epoxide hydrolase using [3H]-tDPPO as substrate",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3478439",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "fulvestrant targets ESR1",
"source_label": "fulvestrant",
"target_label": "ESR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.62",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3478439",
"relation": "IDG (Drug Target)",
"target": "2100",
"properties": {
"id": "fulvestrant targets ESR2",
"source_label": "fulvestrant",
"target_label": "ESR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.74",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3478439",
"relation": "IDG (Drug Target)",
"target": "2101",
"properties": {
"id": "fulvestrant targets ESRRA",
"source_label": "fulvestrant",
"target_label": "ESRRA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "Antagonist activity at ERalpha receptor in human MCF7 cells assessed as inhibition of cell growth after 6 days by crystal violet staining method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3478439",
"relation": "IDG (Drug Target)",
"target": "2852",
"properties": {
"id": "fulvestrant targets GPER1",
"source_label": "fulvestrant",
"target_label": "GPER1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3478439",
"relation": "IDG (Drug Target)",
"target": "9971",
"properties": {
"id": "fulvestrant targets NR1H4",
"source_label": "fulvestrant",
"target_label": "NR1H4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Antagonist activity at human GTS-tagged FXR after 20 mins by TR-FRET assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3478439",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "fulvestrant targets PGR",
"source_label": "fulvestrant",
"target_label": "PGR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.68",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3440",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "furosemide targets CA1",
"source_label": "furosemide",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.21",
"act_comment": "Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3440",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "furosemide targets CA12",
"source_label": "furosemide",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.58",
"act_comment": "Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3440",
"relation": "IDG (Drug Target)",
"target": "23632",
"properties": {
"id": "furosemide targets CA14",
"source_label": "furosemide",
"target_label": "CA14",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.28",
"act_comment": "Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3440",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "furosemide targets CA2",
"source_label": "furosemide",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.19",
"act_comment": "Inhibition of human recombinant full length CA2 by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3440",
"relation": "IDG (Drug Target)",
"target": "762",
"properties": {
"id": "furosemide targets CA4",
"source_label": "furosemide",
"target_label": "CA4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3440",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "furosemide targets CA5A",
"source_label": "furosemide",
"target_label": "CA5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3440",
"relation": "IDG (Drug Target)",
"target": "11238",
"properties": {
"id": "furosemide targets CA5B",
"source_label": "furosemide",
"target_label": "CA5B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.49",
"act_comment": "Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3440",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "furosemide targets CA6",
"source_label": "furosemide",
"target_label": "CA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.61",
"act_comment": "Inhibition of human recombinant full length CA6 by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3440",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "furosemide targets CA7",
"source_label": "furosemide",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3440",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "furosemide targets CA9",
"source_label": "furosemide",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3440",
"relation": "IDG (Drug Target)",
"target": "6557",
"properties": {
"id": "furosemide targets SLC12A1",
"source_label": "furosemide",
"target_label": "SLC12A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:119",
"relation": "IDG (Drug Target)",
"target": "2569",
"properties": {
"id": "aminobutyric acid targets GABRR1",
"source_label": "aminobutyric acid",
"target_label": "GABRR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Agonist activity at human GABAA rho1 receptor expressed in TSA201 cells after 1 min by FLIPR assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3446",
"relation": "IDG (Drug Target)",
"target": "781",
"properties": {
"id": "gabapentin targets CACNA2D1",
"source_label": "gabapentin",
"target_label": "CACNA2D1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.26",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3446",
"relation": "IDG (Drug Target)",
"target": "9254",
"properties": {
"id": "gabapentin targets CACNA2D2",
"source_label": "gabapentin",
"target_label": "CACNA2D2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.928",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:3446",
"relation": "IDG (Drug Target)",
"target": "3786",
"properties": {
"id": "gabapentin targets KCNQ3",
"source_label": "gabapentin",
"target_label": "KCNQ3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.28",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3446",
"relation": "IDG (Drug Target)",
"target": "56479",
"properties": {
"id": "gabapentin targets KCNQ5",
"source_label": "gabapentin",
"target_label": "KCNQ5",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.72",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9651",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "galantamine targets ACHE",
"source_label": "galantamine",
"target_label": "ACHE",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.21",
"act_comment": "Inhibition of human recombinant AChE using acetylthiocholine as substrate",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9651",
"relation": "IDG (Drug Target)",
"target": "590",
"properties": {
"id": "galantamine targets BCHE",
"source_label": "galantamine",
"target_label": "BCHE",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Inhibition of human recombinant BChE using acetylthiocholine as substrate",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3450",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "gallamine targets CHRM2",
"source_label": "gallamine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.148",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5280933",
"relation": "IDG (Drug Target)",
"target": "5465",
"properties": {
"id": "gamolenic acid targets PPARA",
"source_label": "gamolenic acid",
"target_label": "PPARA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Inhibition of PPAR-alpha (unknown origin) by SPA assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280933",
"relation": "IDG (Drug Target)",
"target": "5467",
"properties": {
"id": "gamolenic acid targets PPARD",
"source_label": "gamolenic acid",
"target_label": "PPARD",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Displacement of [3H]GW2433 from Homo sapiens (human) PPARdelta receptor by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3454",
"relation": "IDG (Drug Target)",
"target": "2911",
"properties": {
"id": "ganciclovir targets GRM1",
"source_label": "ganciclovir",
"target_label": "GRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "gefitinib targets ABL1",
"source_label": "gefitinib",
"target_label": "ABL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Binding constant for ABL1(Q252H)-phosphorylated kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "1022",
"properties": {
"id": "gefitinib targets CDK7",
"source_label": "gefitinib",
"target_label": "CDK7",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Binding constant for CDK7 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "11200",
"properties": {
"id": "gefitinib targets CHEK2",
"source_label": "gefitinib",
"target_label": "CHEK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Binding constant for CHEK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "1454",
"properties": {
"id": "gefitinib targets CSNK1E",
"source_label": "gefitinib",
"target_label": "CSNK1E",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "Binding constant for full-length CSNK1E",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "gefitinib targets EGFR",
"source_label": "gefitinib",
"target_label": "EGFR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "Inhibition of EGFR",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "285220",
"properties": {
"id": "gefitinib targets EPHA6",
"source_label": "gefitinib",
"target_label": "EPHA6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.23",
"act_comment": "Binding constant for EPHA6 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "2065",
"properties": {
"id": "gefitinib targets ERBB3",
"source_label": "gefitinib",
"target_label": "ERBB3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Binding constant for ERBB3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "2066",
"properties": {
"id": "gefitinib targets ERBB4",
"source_label": "gefitinib",
"target_label": "ERBB4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "Binding constant for ERBB4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "gefitinib targets FLT3",
"source_label": "gefitinib",
"target_label": "FLT3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for FLT3(D835Y) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "2580",
"properties": {
"id": "gefitinib targets GAK",
"source_label": "gefitinib",
"target_label": "GAK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.15",
"act_comment": "Average Binding Constant for GAK; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "147746",
"properties": {
"id": "gefitinib targets HIPK4",
"source_label": "gefitinib",
"target_label": "HIPK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "Binding constant for HIPK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "3654",
"properties": {
"id": "gefitinib targets IRAK1",
"source_label": "gefitinib",
"target_label": "IRAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.16",
"act_comment": "Binding constant for IRAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "51135",
"properties": {
"id": "gefitinib targets IRAK4",
"source_label": "gefitinib",
"target_label": "IRAK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.27",
"act_comment": "Binding constant for IRAK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "gefitinib targets LCK",
"source_label": "gefitinib",
"target_label": "LCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "Binding constant for LCK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "4067",
"properties": {
"id": "gefitinib targets LYN",
"source_label": "gefitinib",
"target_label": "LYN",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for LYN kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "5607",
"properties": {
"id": "gefitinib targets MAP2K5",
"source_label": "gefitinib",
"target_label": "MAP2K5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Binding constant for MEK5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "80122",
"properties": {
"id": "gefitinib targets MAP3K19",
"source_label": "gefitinib",
"target_label": "MAP3K19",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding constant for YSK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "8569",
"properties": {
"id": "gefitinib targets MKNK1",
"source_label": "gefitinib",
"target_label": "MKNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Binding constant for full-length MKNK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "2872",
"properties": {
"id": "gefitinib targets MKNK2",
"source_label": "gefitinib",
"target_label": "MKNK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Average Binding Constant for MKNK2; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "5753",
"properties": {
"id": "gefitinib targets PTK6",
"source_label": "gefitinib",
"target_label": "PTK6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Kinase Assay: FlashPlates from Perkin Elmer (Boston, Mass., USA) with a 50 \u00ce\u00bcl reaction volume are used. The reaction cocktail was pipetted in 4 steps in the following order: 15 \u00ce\u00bcl of ATP solution (in H2O), 20 \u00ce\u00bcl of assay buffer (see below), 5 \u00ce\u00bcl of test sample in 10% DMSO, 10 \u00ce\u00bcl of enzyme/substrate mixture (in H2O). The assay for all enzymes contained 60 mM HEPES-NaOH, pH 7.5, 3 mM MgCl2, 3 mM MnCl2, 3 \u00ce\u00bcM Na-orthovanadate, 1.2 mM DTT, 50 \u00ce\u00bcg/ml PEG20000, 1 \u00ce\u00bcM [\u00ce\u00b3-33P]-ATP (approx. 8\u00c3\u201410^5 cpm per well), protein kinase (variable amounts see Table 1), and substrate (variable amounts). Certain assays also contained 1 mM CaCl2, 4 mM EDTA, 5 \u00ce\u00bcg/ml Phosphatidylserine and 1 \u00ce\u00bcg/ml 1.2-Dioleyl-glycerol. The MYLK2, CAMK1D, CAMK2A, CAMK2B, CAMK2D, CAMK4, CAMKK2, DAPK2 and EEF2K assays additionally contained 1 \u00ce\u00bcg/ml Calmodulin and 0.5 mM CaCl2. The PRKG1 and PRKG2 assays additionally contained 1 \u00ce\u00bcM cGMP. Recombinant Protein Kinases: All protein kinases were expressed in Sf9 insect cells or ",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "gefitinib targets RIPK2",
"source_label": "gefitinib",
"target_label": "RIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Binding constant for RIPK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "388228",
"properties": {
"id": "gefitinib targets SBK1",
"source_label": "gefitinib",
"target_label": "SBK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "Binding constant for SBK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "9748",
"properties": {
"id": "gefitinib targets SLK",
"source_label": "gefitinib",
"target_label": "SLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "Binding constant for SLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123631",
"relation": "IDG (Drug Target)",
"target": "6793",
"properties": {
"id": "gefitinib targets STK10",
"source_label": "gefitinib",
"target_label": "STK10",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Binding constant for LOK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3463",
"relation": "IDG (Drug Target)",
"target": "7276",
"properties": {
"id": "gemfibrozil targets TTR",
"source_label": "gemfibrozil",
"target_label": "TTR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:73707430",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "gestrinone targets SHBG",
"source_label": "gestrinone",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.11",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3472",
"relation": "IDG (Drug Target)",
"target": "1806",
"properties": {
"id": "gimeracil targets DPYD",
"source_label": "gimeracil",
"target_label": "DPYD",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.638",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:33032",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "glutamic acid targets ADORA3",
"source_label": "glutamic acid",
"target_label": "ADORA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33032",
"relation": "IDG (Drug Target)",
"target": "2891",
"properties": {
"id": "glutamic acid targets GRIA2",
"source_label": "glutamic acid",
"target_label": "GRIA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 2 in HK293 cells using [3H]AMPA as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33032",
"relation": "IDG (Drug Target)",
"target": "2893",
"properties": {
"id": "glutamic acid targets GRIA4",
"source_label": "glutamic acid",
"target_label": "GRIA4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.06",
"act_comment": "Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 4 in HEK293 cells using [3H]AMPA as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33032",
"relation": "IDG (Drug Target)",
"target": "2897",
"properties": {
"id": "glutamic acid targets GRIK1",
"source_label": "glutamic acid",
"target_label": "GRIK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33032",
"relation": "IDG (Drug Target)",
"target": "2899",
"properties": {
"id": "glutamic acid targets GRIK3",
"source_label": "glutamic acid",
"target_label": "GRIK3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Ability to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33032",
"relation": "IDG (Drug Target)",
"target": "2901",
"properties": {
"id": "glutamic acid targets GRIK5",
"source_label": "glutamic acid",
"target_label": "GRIK5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33032",
"relation": "IDG (Drug Target)",
"target": "2911",
"properties": {
"id": "glutamic acid targets GRM1",
"source_label": "glutamic acid",
"target_label": "GRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Displacement of [3H]quisqualate from mGluR1 receptor expressed in BHK cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33032",
"relation": "IDG (Drug Target)",
"target": "2912",
"properties": {
"id": "glutamic acid targets GRM2",
"source_label": "glutamic acid",
"target_label": "GRM2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Compound was tested for the inhibition of metabotropic glutamate receptor 2 (mGluR2).",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33032",
"relation": "IDG (Drug Target)",
"target": "2913",
"properties": {
"id": "glutamic acid targets GRM3",
"source_label": "glutamic acid",
"target_label": "GRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:33032",
"relation": "IDG (Drug Target)",
"target": "2915",
"properties": {
"id": "glutamic acid targets GRM5",
"source_label": "glutamic acid",
"target_label": "GRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "Binding affinity to mGluR5 receptor expressed in BHK cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33032",
"relation": "IDG (Drug Target)",
"target": "6505",
"properties": {
"id": "glutamic acid targets SLC1A1",
"source_label": "glutamic acid",
"target_label": "SLC1A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.29",
"act_comment": "Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:124886",
"relation": "IDG (Drug Target)",
"target": "373156",
"properties": {
"id": "glutathione targets GSTK1",
"source_label": "glutathione",
"target_label": "GSTK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Affinity towards recombinant Glutathione S-transferase (GST) Enzyme.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3488",
"relation": "IDG (Drug Target)",
"target": "5468",
"properties": {
"id": "glibenclamide targets PPARG",
"source_label": "glibenclamide",
"target_label": "PPARG",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.18",
"act_comment": "Binding affinity to PPARgamma (unknown origin) by TR-FRET assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:750",
"relation": "IDG (Drug Target)",
"target": "81285",
"properties": {
"id": "glycine targets OR51E2",
"source_label": "glycine",
"target_label": "OR51E2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.24",
"act_comment": "Agonist activity at PSGR/OR51E2 (unknown origin) expressed in human Hana3A cells co-transfected with CRE-Luc by luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:14982",
"relation": "IDG (Drug Target)",
"target": "3290",
"properties": {
"id": "glycyrrhizic acid targets HSD11B1",
"source_label": "glycyrrhizic acid",
"target_label": "HSD11B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:14982",
"relation": "IDG (Drug Target)",
"target": "3291",
"properties": {
"id": "glycyrrhizic acid targets HSD11B2",
"source_label": "glycyrrhizic acid",
"target_label": "HSD11B2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3503",
"relation": "IDG (Drug Target)",
"target": "231",
"properties": {
"id": "gossypol targets AKR1B1",
"source_label": "gossypol",
"target_label": "AKR1B1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "The compound was tested for inhibitory activity against Aldose reductase from human placenta",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3503",
"relation": "IDG (Drug Target)",
"target": "596",
"properties": {
"id": "gossypol targets BCL2",
"source_label": "gossypol",
"target_label": "BCL2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Displacement of FAM-Bim peptide from human Bcl2 by fluorescence polarization assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3503",
"relation": "IDG (Drug Target)",
"target": "598",
"properties": {
"id": "gossypol targets BCL2L1",
"source_label": "gossypol",
"target_label": "BCL2L1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.32",
"act_comment": "Displacement of FAM-Bak from human Bcl-xL by FP assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3503",
"relation": "IDG (Drug Target)",
"target": "4170",
"properties": {
"id": "gossypol targets MCL1",
"source_label": "gossypol",
"target_label": "MCL1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Displacement of FAM-Bid from human Mcl1 by FP assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284566",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "granisetron targets HTR3A",
"source_label": "granisetron",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284566",
"relation": "IDG (Drug Target)",
"target": "9177",
"properties": {
"id": "granisetron targets HTR3B",
"source_label": "granisetron",
"target_label": "HTR3B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "GRAC: human 5-HT3B selective antagonist",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3519",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "guanfacine targets ADRA1D",
"source_label": "guanfacine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.263",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3519",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "guanfacine targets ADRA2A",
"source_label": "guanfacine",
"target_label": "ADRA2A",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.164",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3519",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "guanfacine targets HTR2A",
"source_label": "guanfacine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.065",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3519",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "guanfacine targets HTR2C",
"source_label": "guanfacine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.119",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3519",
"relation": "IDG (Drug Target)",
"target": "11188",
"properties": {
"id": "guanfacine targets NISCH",
"source_label": "guanfacine",
"target_label": "NISCH",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "Displacement of [125I]PIC from human imidazoline receptor 1 in human platelets analyzed under norepinephrine mask of alpha 2AR",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "5243",
"properties": {
"id": "haloperidol targets ABCB1",
"source_label": "haloperidol",
"target_label": "ABCB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "haloperidol targets ADRA1A",
"source_label": "haloperidol",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "haloperidol targets ADRA1B",
"source_label": "haloperidol",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.097",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "haloperidol targets ADRA1D",
"source_label": "haloperidol",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.553",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "haloperidol targets ADRA2B",
"source_label": "haloperidol",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.319",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "haloperidol targets ADRA2C",
"source_label": "haloperidol",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "haloperidol targets CHRM5",
"source_label": "haloperidol",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.182",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "haloperidol targets DRD1",
"source_label": "haloperidol",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.82",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "haloperidol targets DRD2",
"source_label": "haloperidol",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.15",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "haloperidol targets DRD3",
"source_label": "haloperidol",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "haloperidol targets DRD4",
"source_label": "haloperidol",
"target_label": "DRD4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.42",
"act_comment": "radioligand [3H]spiperone 0.5nM competition binding; human recombinant dopaminereceptors in CHO cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "haloperidol targets DRD5",
"source_label": "haloperidol",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "10682",
"properties": {
"id": "haloperidol targets EBP",
"source_label": "haloperidol",
"target_label": "EBP",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "3005",
"properties": {
"id": "haloperidol targets H1-0",
"source_label": "haloperidol",
"target_label": "H1-0",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, \u00ce\u00b1A1, 5-HT2C and H1 Receptors.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "haloperidol targets HRH1",
"source_label": "haloperidol",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Binding affinity to human cloned histamine H1 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "haloperidol targets HTR1B",
"source_label": "haloperidol",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.569",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "haloperidol targets HTR1D",
"source_label": "haloperidol",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "haloperidol targets HTR2A",
"source_label": "haloperidol",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "haloperidol targets HTR2B",
"source_label": "haloperidol",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "haloperidol targets HTR7",
"source_label": "haloperidol",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.45",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "3756",
"properties": {
"id": "haloperidol targets KCNH1",
"source_label": "haloperidol",
"target_label": "KCNH1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "haloperidol targets KCNH2",
"source_label": "haloperidol",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "haloperidol targets OPRM1",
"source_label": "haloperidol",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.003",
"act_comment": "DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "haloperidol targets SIGMAR1",
"source_label": "haloperidol",
"target_label": "SIGMAR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.92",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3559",
"relation": "IDG (Drug Target)",
"target": "27346",
"properties": {
"id": "haloperidol targets TMEM97",
"source_label": "haloperidol",
"target_label": "TMEM97",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "Displacement of [3H]-DTG from sigma 2 receptor (unknown origin) after 120 mins by liquid scintillation counting method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3561",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "haloprogin targets ADORA3",
"source_label": "haloprogin",
"target_label": "ADORA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3561",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "haloprogin targets ADRA2A",
"source_label": "haloprogin",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.339",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3561",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "haloprogin targets ADRA2B",
"source_label": "haloprogin",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3561",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "haloprogin targets ADRA2C",
"source_label": "haloprogin",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.231",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3561",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "haloprogin targets DRD1",
"source_label": "haloprogin",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3561",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "haloprogin targets DRD3",
"source_label": "haloprogin",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.78",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3561",
"relation": "IDG (Drug Target)",
"target": "2582",
"properties": {
"id": "haloprogin targets GALE",
"source_label": "haloprogin",
"target_label": "GALE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Inhibition of human GalE by HPAEC assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3561",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "haloprogin targets HTR2A",
"source_label": "haloprogin",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3561",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "haloprogin targets OPRK1",
"source_label": "haloprogin",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.338",
"act_comment": "DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3561",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "haloprogin targets SLC6A4",
"source_label": "haloprogin",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.366",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3561",
"relation": "IDG (Drug Target)",
"target": "6865",
"properties": {
"id": "haloprogin targets TACR2",
"source_label": "haloprogin",
"target_label": "TACR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.309",
"act_comment": "DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:72281",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "hesperetin targets CA12",
"source_label": "hesperetin",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.34",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:72281",
"relation": "IDG (Drug Target)",
"target": "762",
"properties": {
"id": "hesperetin targets CA4",
"source_label": "hesperetin",
"target_label": "CA4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.99",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:72281",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "hesperetin targets CA7",
"source_label": "hesperetin",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.48",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:72281",
"relation": "IDG (Drug Target)",
"target": "1545",
"properties": {
"id": "hesperetin targets CYP1B1",
"source_label": "hesperetin",
"target_label": "CYP1B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "Inhibition of human CYP1B1 by EROD assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:72281",
"relation": "IDG (Drug Target)",
"target": "1803",
"properties": {
"id": "hesperetin targets DPP4",
"source_label": "hesperetin",
"target_label": "DPP4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 4 secs followed by substrate addition and measured after 30 mins by luminescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3598",
"relation": "IDG (Drug Target)",
"target": "135",
"properties": {
"id": "hexachlorophene targets ADORA2A",
"source_label": "hexachlorophene",
"target_label": "ADORA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.043",
"act_comment": "DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3598",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "hexachlorophene targets ADORA3",
"source_label": "hexachlorophene",
"target_label": "ADORA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.442",
"act_comment": "DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3598",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "hexachlorophene targets EGFR",
"source_label": "hexachlorophene",
"target_label": "EGFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.126",
"act_comment": "DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr))",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3598",
"relation": "IDG (Drug Target)",
"target": "2100",
"properties": {
"id": "hexachlorophene targets ESR2",
"source_label": "hexachlorophene",
"target_label": "ESR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.01",
"act_comment": "PUBCHEM_BIOASSAY: Estrogen Receptor-beta Coactivator Binding Inhibitors ELISA Secondary Assay. (Class of assay: confirmatory) [Related pubchem assays: 633 (Primary screen preceding this ELISA dose response confirmation assay.), 733 (Primary dose response assay preceding this ELISA dose response confirmation assay.)]",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3598",
"relation": "IDG (Drug Target)",
"target": "5594",
"properties": {
"id": "hexachlorophene targets MAPK1",
"source_label": "hexachlorophene",
"target_label": "MAPK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.708",
"act_comment": "DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3598",
"relation": "IDG (Drug Target)",
"target": "1432",
"properties": {
"id": "hexachlorophene targets MAPK14",
"source_label": "hexachlorophene",
"target_label": "MAPK14",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.057",
"act_comment": "DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3598",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "hexachlorophene targets PTGS2",
"source_label": "hexachlorophene",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.191",
"act_comment": "DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:192197",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "hexestrol targets ESR1",
"source_label": "hexestrol",
"target_label": "ESR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:24199",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "hexocyclium targets CHRM2",
"source_label": "hexocyclium",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:24199",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "hexocyclium targets CHRM3",
"source_label": "hexocyclium",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:24199",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "hexocyclium targets CHRM4",
"source_label": "hexocyclium",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:24199",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "hexocyclium targets CHRM5",
"source_label": "hexocyclium",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3610",
"relation": "IDG (Drug Target)",
"target": "7299",
"properties": {
"id": "hexylresorcinol targets TYR",
"source_label": "hexylresorcinol",
"target_label": "TYR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:774",
"relation": "IDG (Drug Target)",
"target": "11255",
"properties": {
"id": "histamine targets HRH3",
"source_label": "histamine",
"target_label": "HRH3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.28",
"act_comment": "Displacement of [3H[N-alpha-methylhistamine form human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:774",
"relation": "IDG (Drug Target)",
"target": "59340",
"properties": {
"id": "histamine targets HRH4",
"source_label": "histamine",
"target_label": "HRH4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5282593",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "homatropine targets CHRM1",
"source_label": "homatropine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.495",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5282593",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "homatropine targets CHRM2",
"source_label": "homatropine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.125",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5282593",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "homatropine targets CHRM3",
"source_label": "homatropine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5282593",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "homatropine targets CHRM4",
"source_label": "homatropine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.854",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5282593",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "homatropine targets CHRM5",
"source_label": "homatropine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.409",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3634",
"relation": "IDG (Drug Target)",
"target": "328",
"properties": {
"id": "hycanthone targets APEX1",
"source_label": "hycanthone",
"target_label": "APEX1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Binding affinity to full length human APE1 expressed in Escherichia coli BL21/DE3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:23817956",
"relation": "IDG (Drug Target)",
"target": "4353",
"properties": {
"id": "hydralazine targets MPO",
"source_label": "hydralazine",
"target_label": "MPO",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Irreversible inhibition of MPO (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3639",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "hydrochlorothiazide targets CA1",
"source_label": "hydrochlorothiazide",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3639",
"relation": "IDG (Drug Target)",
"target": "6559",
"properties": {
"id": "hydrochlorothiazide targets SLC12A3",
"source_label": "hydrochlorothiazide",
"target_label": "SLC12A3",
"act_type": "A2",
"act_relation": "=",
"act_value": "7.01",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284569",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "hydrocodone targets OPRK1",
"source_label": "hydrocodone",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "Displacement of [3H]-U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284569",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "hydrocodone targets OPRM1",
"source_label": "hydrocodone",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.02",
"act_comment": "Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5320346",
"relation": "IDG (Drug Target)",
"target": "4843",
"properties": {
"id": "hydrocortisone targets NOS2",
"source_label": "hydrocortisone",
"target_label": "NOS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5320346",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "hydrocortisone targets NR3C1",
"source_label": "hydrocortisone",
"target_label": "NR3C1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5320346",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "hydrocortisone targets NR3C2",
"source_label": "hydrocortisone",
"target_label": "NR3C2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.95",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5320346",
"relation": "IDG (Drug Target)",
"target": "866",
"properties": {
"id": "hydrocortisone targets SERPINA6",
"source_label": "hydrocortisone",
"target_label": "SERPINA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.881",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5320346",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "hydrocortisone targets SHBG",
"source_label": "hydrocortisone",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3647",
"relation": "IDG (Drug Target)",
"target": "6559",
"properties": {
"id": "hydroflumethiazide targets SLC12A3",
"source_label": "hydroflumethiazide",
"target_label": "SLC12A3",
"act_type": "A2",
"act_relation": "=",
"act_value": "7.37",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284570",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "hydromorphone targets OPRD1",
"source_label": "hydromorphone",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cells after 3 hrs by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284570",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "hydromorphone targets OPRK1",
"source_label": "hydromorphone",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.55",
"act_comment": "Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284570",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "hydromorphone targets OPRM1",
"source_label": "hydromorphone",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.55",
"act_comment": "Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3652",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "hydroxychloroquine targets SIGMAR1",
"source_label": "hydroxychloroquine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "Displacement of [3H]-pentazocin from the Sigma1 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3652",
"relation": "IDG (Drug Target)",
"target": "54106",
"properties": {
"id": "hydroxychloroquine targets TLR9",
"source_label": "hydroxychloroquine",
"target_label": "TLR9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "Inhibition of hTLR9 CpG2006-induced luciferase reporter gene activation.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3652",
"relation": "IDG (Drug Target)",
"target": "27346",
"properties": {
"id": "hydroxychloroquine targets TMEM97",
"source_label": "hydroxychloroquine",
"target_label": "TMEM97",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Displacement of [3H]-DTG from the Sigma2 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3658",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "hydroxyzine targets DRD2",
"source_label": "hydroxyzine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Binding affinity to D2 receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3658",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "hydroxyzine targets HRH1",
"source_label": "hydroxyzine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.699",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3658",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "hydroxyzine targets HTR2A",
"source_label": "hydroxyzine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Binding affinity to 5-HT2A receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280567",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "hymecromone targets CA9",
"source_label": "hymecromone",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "Inhibition of human recombinant CA9 after 6 hrs by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280567",
"relation": "IDG (Drug Target)",
"target": "3293",
"properties": {
"id": "hymecromone targets HSD17B3",
"source_label": "hymecromone",
"target_label": "HSD17B3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Inhibition of human 17beta-HSD3 expressed in HeLa cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6334600",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "hyoscyamine targets CHRM1",
"source_label": "hyoscyamine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6334600",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "hyoscyamine targets CHRM2",
"source_label": "hyoscyamine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6334600",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "hyoscyamine targets CHRM3",
"source_label": "hyoscyamine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6334600",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "hyoscyamine targets CHRM4",
"source_label": "hyoscyamine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6334600",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "hyoscyamine targets CHRM5",
"source_label": "hyoscyamine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60852",
"relation": "IDG (Drug Target)",
"target": "2224",
"properties": {
"id": "ibandronic acid targets FDPS",
"source_label": "ibandronic acid",
"target_label": "FDPS",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.44",
"act_comment": "Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3671",
"relation": "IDG (Drug Target)",
"target": "5141",
"properties": {
"id": "ibudilast targets PDE4A",
"source_label": "ibudilast",
"target_label": "PDE4A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.27",
"act_comment": "Inhibition of human PDE4A",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3671",
"relation": "IDG (Drug Target)",
"target": "5142",
"properties": {
"id": "ibudilast targets PDE4B",
"source_label": "ibudilast",
"target_label": "PDE4B",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.19",
"act_comment": "Inhibition of human PDE4B",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3671",
"relation": "IDG (Drug Target)",
"target": "5143",
"properties": {
"id": "ibudilast targets PDE4C",
"source_label": "ibudilast",
"target_label": "PDE4C",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Inhibition of human PDE4C",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3671",
"relation": "IDG (Drug Target)",
"target": "5144",
"properties": {
"id": "ibudilast targets PDE4D",
"source_label": "ibudilast",
"target_label": "PDE4D",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.78",
"act_comment": "Inhibition of human PDE4D",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3672",
"relation": "IDG (Drug Target)",
"target": "3576",
"properties": {
"id": "ibuprofen targets CXCL8",
"source_label": "ibuprofen",
"target_label": "CXCL8",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60753",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "ibutilide targets KCNH2",
"source_label": "ibutilide",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Inhibition of human Potassium channel HERG expressed in mammalian cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3686",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "idebenone targets CYP2C19",
"source_label": "idebenone",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.097",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5905",
"relation": "IDG (Drug Target)",
"target": "7083",
"properties": {
"id": "idoxuridine targets TK1",
"source_label": "idoxuridine",
"target_label": "TK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.05",
"act_comment": "Binding affinity constant against HSV-1 thymidine kinase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3689",
"relation": "IDG (Drug Target)",
"target": "2904",
"properties": {
"id": "ifenprodil targets GRIN2B",
"source_label": "ifenprodil",
"target_label": "GRIN2B",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Inhibition of NMDA receptor GluN2B subunit (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3689",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "ifenprodil targets HRH1",
"source_label": "ifenprodil",
"target_label": "HRH1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Compound was tested for the binding affinity against histamine H1 receptor by using [3H]mepyramine as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3689",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "ifenprodil targets KCNH2",
"source_label": "ifenprodil",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Inhibition of human ERG",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3689",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "ifenprodil targets SIGMAR1",
"source_label": "ifenprodil",
"target_label": "SIGMAR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.41",
"act_comment": "Compound was tested for the binding affinity against sigma receptor by using [3H]-+3PPP as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311181",
"relation": "IDG (Drug Target)",
"target": "5729",
"properties": {
"id": "iloprost targets PTGDR",
"source_label": "iloprost",
"target_label": "PTGDR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5311181",
"relation": "IDG (Drug Target)",
"target": "5731",
"properties": {
"id": "iloprost targets PTGER1",
"source_label": "iloprost",
"target_label": "PTGER1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5311181",
"relation": "IDG (Drug Target)",
"target": "5733",
"properties": {
"id": "iloprost targets PTGER3",
"source_label": "iloprost",
"target_label": "PTGER3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5311181",
"relation": "IDG (Drug Target)",
"target": "5734",
"properties": {
"id": "iloprost targets PTGER4",
"source_label": "iloprost",
"target_label": "PTGER4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5311181",
"relation": "IDG (Drug Target)",
"target": "5737",
"properties": {
"id": "iloprost targets PTGFR",
"source_label": "iloprost",
"target_label": "PTGFR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5311181",
"relation": "IDG (Drug Target)",
"target": "5739",
"properties": {
"id": "iloprost targets PTGIR",
"source_label": "iloprost",
"target_label": "PTGIR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.75",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "imatinib targets ABL1",
"source_label": "imatinib",
"target_label": "ABL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.96",
"act_comment": "Binding constant for ABL1-non phosphorylated kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "27",
"properties": {
"id": "imatinib targets ABL2",
"source_label": "imatinib",
"target_label": "ABL2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "Binding affinity to human active site of N-terminal hexahistidine-tagged ABL2 expressed in Trichoplusia ni infected Sf9 cells by isothermal titration calorimetric assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "640",
"properties": {
"id": "imatinib targets BLK",
"source_label": "imatinib",
"target_label": "BLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Binding constant for BLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "imatinib targets CA1",
"source_label": "imatinib",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "imatinib targets CA12",
"source_label": "imatinib",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "23632",
"properties": {
"id": "imatinib targets CA14",
"source_label": "imatinib",
"target_label": "CA14",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "imatinib targets CA2",
"source_label": "imatinib",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "761",
"properties": {
"id": "imatinib targets CA3",
"source_label": "imatinib",
"target_label": "CA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Inhibition of human carbonic anhydrase 3 by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "imatinib targets CA6",
"source_label": "imatinib",
"target_label": "CA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "imatinib targets CA7",
"source_label": "imatinib",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "imatinib targets CA9",
"source_label": "imatinib",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.12",
"act_comment": "Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "1436",
"properties": {
"id": "imatinib targets CSF1R",
"source_label": "imatinib",
"target_label": "CSF1R",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Binding constant for CSF1R kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "780",
"properties": {
"id": "imatinib targets DDR1",
"source_label": "imatinib",
"target_label": "DDR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.15",
"act_comment": "Binding constant for DDR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "4921",
"properties": {
"id": "imatinib targets DDR2",
"source_label": "imatinib",
"target_label": "DDR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.82",
"act_comment": "Binding constant for DDR2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "1654",
"properties": {
"id": "imatinib targets DDX3X",
"source_label": "imatinib",
"target_label": "DDX3X",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "2580",
"properties": {
"id": "imatinib targets GAK",
"source_label": "imatinib",
"target_label": "GAK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for GAK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "147746",
"properties": {
"id": "imatinib targets HIPK4",
"source_label": "imatinib",
"target_label": "HIPK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "Binding constant for HIPK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "imatinib targets HTR2A",
"source_label": "imatinib",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.268",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "imatinib targets KIT",
"source_label": "imatinib",
"target_label": "KIT",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Binding constant for KIT kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "imatinib targets LCK",
"source_label": "imatinib",
"target_label": "LCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "Binding constant for LCK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "4067",
"properties": {
"id": "imatinib targets LYN",
"source_label": "imatinib",
"target_label": "LYN",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Binding constant for LYN kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "4835",
"properties": {
"id": "imatinib targets NQO2",
"source_label": "imatinib",
"target_label": "NQO2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Competitive inhibition of human recombinant NQO2-mediated mitomycin C metabolism using NADH as cosubstrate incubated for 5 mins prior to NADH addition measured after 30 mins by Michaelis-Menten plot analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "5156",
"properties": {
"id": "imatinib targets PDGFRA",
"source_label": "imatinib",
"target_label": "PDGFRA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.51",
"act_comment": "Binding constant for PDGFRA kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "imatinib targets PDGFRB",
"source_label": "imatinib",
"target_label": "PDGFRB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Binding constant for PDGFRB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "79837",
"properties": {
"id": "imatinib targets PIP4K2C",
"source_label": "imatinib",
"target_label": "PIP4K2C",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Binding constant for PIP5K2C kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "55244",
"properties": {
"id": "imatinib targets SLC47A1",
"source_label": "imatinib",
"target_label": "SLC47A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "Inhibition of human MATE1-mediated [14]-metformin uptake expressed in polarized MDCK2 cells after 5 mins by liquid scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "146802",
"properties": {
"id": "imatinib targets SLC47A2",
"source_label": "imatinib",
"target_label": "SLC47A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells up to 500 uM after 1.5 mins by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "imatinib targets SLC6A4",
"source_label": "imatinib",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.128",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5291",
"relation": "IDG (Drug Target)",
"target": "6916",
"properties": {
"id": "imatinib targets TBXAS1",
"source_label": "imatinib",
"target_label": "TBXAS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.703",
"act_comment": "DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3696",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "imipramine targets ADORA3",
"source_label": "imipramine",
"target_label": "ADORA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.36",
"act_comment": "Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3696",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "imipramine targets ADRA1A",
"source_label": "imipramine",
"target_label": "ADRA1A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.495",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3696",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "imipramine targets ADRA2B",
"source_label": "imipramine",
"target_label": "ADRA2B",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3696",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "imipramine targets CHRM1",
"source_label": "imipramine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.377",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3696",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "imipramine targets CHRM2",
"source_label": "imipramine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.08",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3696",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "imipramine targets CHRM3",
"source_label": "imipramine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.222",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3696",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "imipramine targets CHRM4",
"source_label": "imipramine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.951",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3696",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "imipramine targets CHRM5",
"source_label": "imipramine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.081",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3696",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "imipramine targets DRD2",
"source_label": "imipramine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.173",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3696",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "imipramine targets DRD3",
"source_label": "imipramine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.412",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3696",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "imipramine targets HRH1",
"source_label": "imipramine",
"target_label": "HRH1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.614",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3696",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "imipramine targets HTR2A",
"source_label": "imipramine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.825",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3696",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "imipramine targets HTR2C",
"source_label": "imipramine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.796",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3696",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "imipramine targets SIGMAR1",
"source_label": "imipramine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.284",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3696",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "imipramine targets SLC6A2",
"source_label": "imipramine",
"target_label": "SLC6A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.432",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3696",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "imipramine targets SLC6A4",
"source_label": "imipramine",
"target_label": "SLC6A4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.854",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3699",
"relation": "IDG (Drug Target)",
"target": "2224",
"properties": {
"id": "incadronic acid targets FDPS",
"source_label": "incadronic acid",
"target_label": "FDPS",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.523",
"act_comment": "inhibition of human recombinant FPP synthase",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:3702",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "indapamide targets CA12",
"source_label": "indapamide",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3702",
"relation": "IDG (Drug Target)",
"target": "377677",
"properties": {
"id": "indapamide targets CA13",
"source_label": "indapamide",
"target_label": "CA13",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3702",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "indapamide targets CA2",
"source_label": "indapamide",
"target_label": "CA2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Binding affinity to human recombinant carbonic anhydrase 2 by isothermal titration calorimetry assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3702",
"relation": "IDG (Drug Target)",
"target": "762",
"properties": {
"id": "indapamide targets CA4",
"source_label": "indapamide",
"target_label": "CA4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.67",
"act_comment": "Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3702",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "indapamide targets CA5A",
"source_label": "indapamide",
"target_label": "CA5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3702",
"relation": "IDG (Drug Target)",
"target": "11238",
"properties": {
"id": "indapamide targets CA5B",
"source_label": "indapamide",
"target_label": "CA5B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.56",
"act_comment": "Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3702",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "indapamide targets CA6",
"source_label": "indapamide",
"target_label": "CA6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Binding affinity to human recombinant carbonic anhydrase 6 expressed in Escherichia coli Rosetta2 (DE3) by thermal shift assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3702",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "indapamide targets CA7",
"source_label": "indapamide",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.64",
"act_comment": "Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3702",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "indapamide targets CA9",
"source_label": "indapamide",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.44",
"act_comment": "Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3702",
"relation": "IDG (Drug Target)",
"target": "6559",
"properties": {
"id": "indapamide targets SLC12A3",
"source_label": "indapamide",
"target_label": "SLC12A3",
"act_type": "A2",
"act_relation": "=",
"act_value": "7.54",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5362440",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "indinavir targets CYP3A4",
"source_label": "indinavir",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.398",
"act_comment": "DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:178039",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "indisetron targets HTR3A",
"source_label": "indisetron",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.74",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:3715",
"relation": "IDG (Drug Target)",
"target": "8644",
"properties": {
"id": "indomethacin targets AKR1C3",
"source_label": "indomethacin",
"target_label": "AKR1C3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Inhibition of human recombinant AKR1C3-mediated NADP+-dependent oxidation of S-(+)-1,2,3,4-tetrahydro-1-naphthol",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3715",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "indomethacin targets AR",
"source_label": "indomethacin",
"target_label": "AR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.85",
"act_comment": "Agonist activity at androgen receptor (unknown origin) expressed in HeLa cells co-expressing PSA-(ARE)4-Luc13 assessed as induction of DHT-induced luciferase activity after 20 mins by luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3715",
"relation": "IDG (Drug Target)",
"target": "3576",
"properties": {
"id": "indomethacin targets CXCL8",
"source_label": "indomethacin",
"target_label": "CXCL8",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3715",
"relation": "IDG (Drug Target)",
"target": "3743",
"properties": {
"id": "indomethacin targets KCNA7",
"source_label": "indomethacin",
"target_label": "KCNA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3715",
"relation": "IDG (Drug Target)",
"target": "4513",
"properties": {
"id": "indomethacin targets COX2",
"source_label": "indomethacin",
"target_label": "COX2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Inhibition of human COX2 assessed as reduction in PGF2alpha production by ELISA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3715",
"relation": "IDG (Drug Target)",
"target": "93100",
"properties": {
"id": "indomethacin targets NAPRT",
"source_label": "indomethacin",
"target_label": "NAPRT",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.82",
"act_comment": "Inhibition of NAPRT (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3715",
"relation": "IDG (Drug Target)",
"target": "5468",
"properties": {
"id": "indomethacin targets PPARG",
"source_label": "indomethacin",
"target_label": "PPARG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.38",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3715",
"relation": "IDG (Drug Target)",
"target": "11251",
"properties": {
"id": "indomethacin targets PTGDR2",
"source_label": "indomethacin",
"target_label": "PTGDR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.53",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3715",
"relation": "IDG (Drug Target)",
"target": "5732",
"properties": {
"id": "indomethacin targets PTGER2",
"source_label": "indomethacin",
"target_label": "PTGER2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.691",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3715",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "indomethacin targets PTGS1",
"source_label": "indomethacin",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.21",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3715",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "indomethacin targets PTGS2",
"source_label": "indomethacin",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:33625",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "indoramin targets ADRA1A",
"source_label": "indoramin",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.43",
"act_comment": "The compound was tested for binding affinity against Alpha-1A adrenergic receptor from human clones.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33625",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "indoramin targets ADRA1B",
"source_label": "indoramin",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "The compound was tested for binding affinity against Alpha-1B adrenergic receptor, from hamster clones.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33625",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "indoramin targets ADRA1D",
"source_label": "indoramin",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Binding affinity against Alpha-1D adrenergic receptor, from human clones.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33625",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "indoramin targets ADRA2B",
"source_label": "indoramin",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Binding affinity against Alpha-2B adrenergic receptor from human clones.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33625",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "indoramin targets ADRA2C",
"source_label": "indoramin",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.32",
"act_comment": "Binding affinity against Alpha-2C adrenergic receptor from human clones.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33625",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "indoramin targets DRD4",
"source_label": "indoramin",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.745",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:65954",
"relation": "IDG (Drug Target)",
"target": "7150",
"properties": {
"id": "intoplicine targets TOP1",
"source_label": "intoplicine",
"target_label": "TOP1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:65954",
"relation": "IDG (Drug Target)",
"target": "116447",
"properties": {
"id": "intoplicine targets TOP1MT",
"source_label": "intoplicine",
"target_label": "TOP1MT",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3728",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "diiodohydroxyquinoline targets ADORA3",
"source_label": "diiodohydroxyquinoline",
"target_label": "ADORA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.278",
"act_comment": "DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3728",
"relation": "IDG (Drug Target)",
"target": "5594",
"properties": {
"id": "diiodohydroxyquinoline targets MAPK1",
"source_label": "diiodohydroxyquinoline",
"target_label": "MAPK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.532",
"act_comment": "DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3728",
"relation": "IDG (Drug Target)",
"target": "1432",
"properties": {
"id": "diiodohydroxyquinoline targets MAPK14",
"source_label": "diiodohydroxyquinoline",
"target_label": "MAPK14",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.439",
"act_comment": "DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:657309",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "ipratropium targets CHRM1",
"source_label": "ipratropium",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.31",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:657309",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "ipratropium targets CHRM2",
"source_label": "ipratropium",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.824",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:657309",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "ipratropium targets CHRM3",
"source_label": "ipratropium",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.292",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:657309",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "ipratropium targets CHRM4",
"source_label": "ipratropium",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.181",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:657309",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "ipratropium targets CHRM5",
"source_label": "ipratropium",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.77",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:21722",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "iprindole targets HRH1",
"source_label": "iprindole",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.921",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3749",
"relation": "IDG (Drug Target)",
"target": "185",
"properties": {
"id": "irbesartan targets AGTR1",
"source_label": "irbesartan",
"target_label": "AGTR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "Inhibitory concentration against angiotensin II receptor, type 1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60838",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "irinotecan targets ACHE",
"source_label": "irinotecan",
"target_label": "ACHE",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Inhibition of human AChE",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60838",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "irinotecan targets ADRA2C",
"source_label": "irinotecan",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.336",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:60838",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "irinotecan targets CHRM4",
"source_label": "irinotecan",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.664",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3762",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "isoetarine targets ADRB2",
"source_label": "isoetarine",
"target_label": "ADRB2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding affinity to beta-2 adrenergic receptor (unknown origin) at 1 to 10000 nM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "isoprenaline targets ADRB1",
"source_label": "isoprenaline",
"target_label": "ADRB1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "isoprenaline targets ADRB2",
"source_label": "isoprenaline",
"target_label": "ADRB2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "isoprenaline targets ADRB3",
"source_label": "isoprenaline",
"target_label": "ADRB3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "50834",
"properties": {
"id": "isoprenaline targets TAS2R1",
"source_label": "isoprenaline",
"target_label": "TAS2R1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R1 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "50839",
"properties": {
"id": "isoprenaline targets TAS2R10",
"source_label": "isoprenaline",
"target_label": "TAS2R10",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "50838",
"properties": {
"id": "isoprenaline targets TAS2R13",
"source_label": "isoprenaline",
"target_label": "TAS2R13",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R13 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "50840",
"properties": {
"id": "isoprenaline targets TAS2R14",
"source_label": "isoprenaline",
"target_label": "TAS2R14",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "50833",
"properties": {
"id": "isoprenaline targets TAS2R16",
"source_label": "isoprenaline",
"target_label": "TAS2R16",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "259294",
"properties": {
"id": "isoprenaline targets TAS2R19",
"source_label": "isoprenaline",
"target_label": "TAS2R19",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R48 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "259295",
"properties": {
"id": "isoprenaline targets TAS2R20",
"source_label": "isoprenaline",
"target_label": "TAS2R20",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R49 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "50831",
"properties": {
"id": "isoprenaline targets TAS2R3",
"source_label": "isoprenaline",
"target_label": "TAS2R3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R3 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "259293",
"properties": {
"id": "isoprenaline targets TAS2R30",
"source_label": "isoprenaline",
"target_label": "TAS2R30",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R47 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "259290",
"properties": {
"id": "isoprenaline targets TAS2R31",
"source_label": "isoprenaline",
"target_label": "TAS2R31",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "5726",
"properties": {
"id": "isoprenaline targets TAS2R38",
"source_label": "isoprenaline",
"target_label": "TAS2R38",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "259285",
"properties": {
"id": "isoprenaline targets TAS2R39",
"source_label": "isoprenaline",
"target_label": "TAS2R39",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "50832",
"properties": {
"id": "isoprenaline targets TAS2R4",
"source_label": "isoprenaline",
"target_label": "TAS2R4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "259286",
"properties": {
"id": "isoprenaline targets TAS2R40",
"source_label": "isoprenaline",
"target_label": "TAS2R40",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R40 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "259287",
"properties": {
"id": "isoprenaline targets TAS2R41",
"source_label": "isoprenaline",
"target_label": "TAS2R41",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R41 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "353164",
"properties": {
"id": "isoprenaline targets TAS2R42",
"source_label": "isoprenaline",
"target_label": "TAS2R42",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R55 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "259289",
"properties": {
"id": "isoprenaline targets TAS2R43",
"source_label": "isoprenaline",
"target_label": "TAS2R43",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R43 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "259291",
"properties": {
"id": "isoprenaline targets TAS2R45",
"source_label": "isoprenaline",
"target_label": "TAS2R45",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R45 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "259292",
"properties": {
"id": "isoprenaline targets TAS2R46",
"source_label": "isoprenaline",
"target_label": "TAS2R46",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R46 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "54429",
"properties": {
"id": "isoprenaline targets TAS2R5",
"source_label": "isoprenaline",
"target_label": "TAS2R5",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R5 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "259296",
"properties": {
"id": "isoprenaline targets TAS2R50",
"source_label": "isoprenaline",
"target_label": "TAS2R50",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R50 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "338398",
"properties": {
"id": "isoprenaline targets TAS2R60",
"source_label": "isoprenaline",
"target_label": "TAS2R60",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R60 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "50837",
"properties": {
"id": "isoprenaline targets TAS2R7",
"source_label": "isoprenaline",
"target_label": "TAS2R7",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R7 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "50836",
"properties": {
"id": "isoprenaline targets TAS2R8",
"source_label": "isoprenaline",
"target_label": "TAS2R8",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R8 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3779",
"relation": "IDG (Drug Target)",
"target": "50835",
"properties": {
"id": "isoprenaline targets TAS2R9",
"source_label": "isoprenaline",
"target_label": "TAS2R9",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Agonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5282379",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "isotretinoin targets HTR2B",
"source_label": "isotretinoin",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.268",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5282379",
"relation": "IDG (Drug Target)",
"target": "5594",
"properties": {
"id": "isotretinoin targets MAPK1",
"source_label": "isotretinoin",
"target_label": "MAPK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.335",
"act_comment": "DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5282379",
"relation": "IDG (Drug Target)",
"target": "81285",
"properties": {
"id": "isotretinoin targets OR51E2",
"source_label": "isotretinoin",
"target_label": "OR51E2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "Antagonist activity at PSGR/OR51E2 (unknown origin) expressed in human Hana3A cells co-transfected with CRE-Luc by luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5282379",
"relation": "IDG (Drug Target)",
"target": "5914",
"properties": {
"id": "isotretinoin targets RARA",
"source_label": "isotretinoin",
"target_label": "RARA",
"act_type": "ED50",
"act_relation": "=",
"act_value": "8.229",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5282379",
"relation": "IDG (Drug Target)",
"target": "5959",
"properties": {
"id": "isotretinoin targets RDH5",
"source_label": "isotretinoin",
"target_label": "RDH5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3784",
"relation": "IDG (Drug Target)",
"target": "775",
"properties": {
"id": "isradipine targets CACNA1C",
"source_label": "isradipine",
"target_label": "CACNA1C",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3784",
"relation": "IDG (Drug Target)",
"target": "776",
"properties": {
"id": "isradipine targets CACNA1D",
"source_label": "isradipine",
"target_label": "CACNA1D",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "Recombinant Cav1.3 calcium channel complexes expressed in tsA201-cells",
"act_source": "IUPHAR"
}
},
{
"source": "CID:55283",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "itraconazole targets ADRB2",
"source_label": "itraconazole",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:55283",
"relation": "IDG (Drug Target)",
"target": "554",
"properties": {
"id": "itraconazole targets AVPR2",
"source_label": "itraconazole",
"target_label": "AVPR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Inhibition of vasopressin-stimulated vasopressin V2 receptor in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:55283",
"relation": "IDG (Drug Target)",
"target": "1233",
"properties": {
"id": "itraconazole targets CCR4",
"source_label": "itraconazole",
"target_label": "CCR4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22",
"act_source": "CHEMBL"
}
},
{
"source": "CID:55283",
"relation": "IDG (Drug Target)",
"target": "3577",
"properties": {
"id": "itraconazole targets CXCR1",
"source_label": "itraconazole",
"target_label": "CXCR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Inhibition of CX3CL1-stimulated CX3CR1 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:55283",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "itraconazole targets CYP3A4",
"source_label": "itraconazole",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.046",
"act_comment": "DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3822",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "ketanserin targets ADORA3",
"source_label": "ketanserin",
"target_label": "ADORA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.57",
"act_comment": "Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3822",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "ketanserin targets ADRA1A",
"source_label": "ketanserin",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3822",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "ketanserin targets ADRA1B",
"source_label": "ketanserin",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3822",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "ketanserin targets ADRA1D",
"source_label": "ketanserin",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3822",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "ketanserin targets ADRA2B",
"source_label": "ketanserin",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.701",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3822",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "ketanserin targets DRD1",
"source_label": "ketanserin",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3822",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "ketanserin targets DRD2",
"source_label": "ketanserin",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding affinity for Dopamine receptor D2 by displacement of [3H]-spiperone",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3822",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "ketanserin targets DRD4",
"source_label": "ketanserin",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.46",
"act_comment": "Binding affinity towards human dopamine receptor D4",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3822",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "ketanserin targets HRH1",
"source_label": "ketanserin",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.747",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3822",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "ketanserin targets HTR1D",
"source_label": "ketanserin",
"target_label": "HTR1D",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3822",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "ketanserin targets HTR1F",
"source_label": "ketanserin",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.903",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3822",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "ketanserin targets HTR2A",
"source_label": "ketanserin",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "GRAC: human 5-HT2A selective antagonist",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3822",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "ketanserin targets HTR2B",
"source_label": "ketanserin",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3822",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "ketanserin targets HTR2C",
"source_label": "ketanserin",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3822",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "ketanserin targets HTR7",
"source_label": "ketanserin",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3822",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "ketanserin targets KCNH2",
"source_label": "ketanserin",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.97",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3822",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "ketanserin targets SIGMAR1",
"source_label": "ketanserin",
"target_label": "SIGMAR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "The compound was tested for affinity towards sigma-3 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3822",
"relation": "IDG (Drug Target)",
"target": "6571",
"properties": {
"id": "ketanserin targets SLC18A2",
"source_label": "ketanserin",
"target_label": "SLC18A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.155",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:10101",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "ketobemidone targets OPRD1",
"source_label": "ketobemidone",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.845",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:10101",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "ketobemidone targets OPRK1",
"source_label": "ketobemidone",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.223",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:10101",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "ketobemidone targets OPRM1",
"source_label": "ketobemidone",
"target_label": "OPRM1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:456201",
"relation": "IDG (Drug Target)",
"target": "5243",
"properties": {
"id": "ketoconazole targets ABCB1",
"source_label": "ketoconazole",
"target_label": "ABCB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:456201",
"relation": "IDG (Drug Target)",
"target": "1584",
"properties": {
"id": "ketoconazole targets CYP11B1",
"source_label": "ketoconazole",
"target_label": "CYP11B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.896",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:456201",
"relation": "IDG (Drug Target)",
"target": "1585",
"properties": {
"id": "ketoconazole targets CYP11B2",
"source_label": "ketoconazole",
"target_label": "CYP11B2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.174",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:456201",
"relation": "IDG (Drug Target)",
"target": "1586",
"properties": {
"id": "ketoconazole targets CYP17A1",
"source_label": "ketoconazole",
"target_label": "CYP17A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.28",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:456201",
"relation": "IDG (Drug Target)",
"target": "1588",
"properties": {
"id": "ketoconazole targets CYP19A1",
"source_label": "ketoconazole",
"target_label": "CYP19A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Inhibition of human recombinant aromatase assessed as conversion of O-dibenzylfluorescein benzyl ester substrate to fluorescein byproduct by fluorometric assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:456201",
"relation": "IDG (Drug Target)",
"target": "1591",
"properties": {
"id": "ketoconazole targets CYP24A1",
"source_label": "ketoconazole",
"target_label": "CYP24A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.506",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:456201",
"relation": "IDG (Drug Target)",
"target": "1594",
"properties": {
"id": "ketoconazole targets CYP27B1",
"source_label": "ketoconazole",
"target_label": "CYP27B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "Inhibition of human CYP27B1 expressed in Escherichia coli assessed as reduction in hydrolase activity incubated for 25 mins using Adx, AdR and 1,25(OH)2D3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:456201",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "ketoconazole targets CYP3A4",
"source_label": "ketoconazole",
"target_label": "CYP3A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:456201",
"relation": "IDG (Drug Target)",
"target": "1577",
"properties": {
"id": "ketoconazole targets CYP3A5",
"source_label": "ketoconazole",
"target_label": "CYP3A5",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Fluorescent High Throughput P450 Assay: The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest) The IC50s of the compounds was calculated on isoenzymes (CYP1A2, CYP2C9, CYP2C19, CYP2C8, CYP2B6, CYP2D6, CYP2E1, CYP3A4 and CYP3A5). Inhibition of the P450 isoforms was measured in specific assays using specific substrates that become fluorescent upon CYP metabolism. Compounds, dissolved in ACN (acetonitrile) (CYP2E1, CYP2C8, CYP2B6, CYP3A5) or DMSO (all remaining isoforms), were tested in duplicate (n=2) in concentration-response curves (eight concentrations) in a 96-well plate containing incubation/NADPH regenerating buffer. Specific isoenzymes and substrates were added and incubated at 37\u00c2\u00b0 C. Reactions were terminated at different times, depending on the assays, and plates read on a Fluoroskan Ascent at the appropriate emission/excitation wavelengths. Concentration-response curves performed in duplicate for known i",
"act_source": "CHEMBL"
}
},
{
"source": "CID:456201",
"relation": "IDG (Drug Target)",
"target": "1595",
"properties": {
"id": "ketoconazole targets CYP51A1",
"source_label": "ketoconazole",
"target_label": "CYP51A1",
"act_type": "app Ki",
"act_relation": "=",
"act_value": "7.197",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:456201",
"relation": "IDG (Drug Target)",
"target": "3744",
"properties": {
"id": "ketoconazole targets KCNA10",
"source_label": "ketoconazole",
"target_label": "KCNA10",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:456201",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "ketoconazole targets SLC6A4",
"source_label": "ketoconazole",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3825",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "ketoprofen targets PTGS1",
"source_label": "ketoprofen",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.33",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3825",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "ketoprofen targets PTGS2",
"source_label": "ketoprofen",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3826",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "ketorolac targets PTGS1",
"source_label": "ketorolac",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.72",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3826",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "ketorolac targets PTGS2",
"source_label": "ketorolac",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3827",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "ketotifen targets ADRA2A",
"source_label": "ketotifen",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.086",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3827",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "ketotifen targets ADRA2B",
"source_label": "ketotifen",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.489",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3827",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "ketotifen targets CHRM1",
"source_label": "ketotifen",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.016",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3827",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "ketotifen targets CHRM2",
"source_label": "ketotifen",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.359",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3827",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "ketotifen targets CHRM3",
"source_label": "ketotifen",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.577",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3827",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "ketotifen targets CHRM4",
"source_label": "ketotifen",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.075",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3827",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "ketotifen targets CHRM5",
"source_label": "ketotifen",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.73",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3827",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "ketotifen targets DRD1",
"source_label": "ketotifen",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.361",
"act_comment": "DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3827",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "ketotifen targets DRD3",
"source_label": "ketotifen",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.176",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3827",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "ketotifen targets HRH1",
"source_label": "ketotifen",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.509",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3827",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "ketotifen targets HTR2A",
"source_label": "ketotifen",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.047",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3827",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "ketotifen targets HTR2B",
"source_label": "ketotifen",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.538",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3827",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "ketotifen targets HTR2C",
"source_label": "ketotifen",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.076",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3827",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "ketotifen targets HTR6",
"source_label": "ketotifen",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.276",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:134044",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "labetalol targets ADRA1D",
"source_label": "labetalol",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.638",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:134044",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "labetalol targets ADRB1",
"source_label": "labetalol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.234",
"act_comment": "DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:134044",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "labetalol targets ADRB2",
"source_label": "labetalol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.959",
"act_comment": "DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:134044",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "labetalol targets CYP2D6",
"source_label": "labetalol",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.097",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:134044",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "labetalol targets HTR1A",
"source_label": "labetalol",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.648",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:134044",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "labetalol targets SIGMAR1",
"source_label": "labetalol",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.117",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5311217",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "lacidipine targets CYP3A4",
"source_label": "lacidipine",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.046",
"act_comment": "DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:122173799",
"relation": "IDG (Drug Target)",
"target": "6752",
"properties": {
"id": "lanreotide targets SSTR2",
"source_label": "lanreotide",
"target_label": "SSTR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:122173799",
"relation": "IDG (Drug Target)",
"target": "6753",
"properties": {
"id": "lanreotide targets SSTR3",
"source_label": "lanreotide",
"target_label": "SSTR3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:122173799",
"relation": "IDG (Drug Target)",
"target": "6755",
"properties": {
"id": "lanreotide targets SSTR5",
"source_label": "lanreotide",
"target_label": "SSTR5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3883",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "lansoprazole targets CYP2C19",
"source_label": "lansoprazole",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.473",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3883",
"relation": "IDG (Drug Target)",
"target": "4137",
"properties": {
"id": "lansoprazole targets MAPT",
"source_label": "lansoprazole",
"target_label": "MAPT",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.6",
"act_comment": "Binding affinity to heparin induced human Tau 441 at 50 pM to 500 nM after 30 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3883",
"relation": "IDG (Drug Target)",
"target": "162466",
"properties": {
"id": "lansoprazole targets PHOSPHO1",
"source_label": "lansoprazole",
"target_label": "PHOSPHO1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "PUBCHEM_BIOASSAY: SAR assay for compounds that inhibit PHOSPHO1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1545, AID1565, AID1574]",
"act_source": "CHEMBL"
}
},
{
"source": "CID:208908",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "lapatinib targets EGFR",
"source_label": "lapatinib",
"target_label": "EGFR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.04",
"act_comment": "Binding constant for EGFR(G719C) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:208908",
"relation": "IDG (Drug Target)",
"target": "2064",
"properties": {
"id": "lapatinib targets ERBB2",
"source_label": "lapatinib",
"target_label": "ERBB2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.15",
"act_comment": "Binding constant for ERBB2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:208908",
"relation": "IDG (Drug Target)",
"target": "2066",
"properties": {
"id": "lapatinib targets ERBB4",
"source_label": "lapatinib",
"target_label": "ERBB4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.27",
"act_comment": "Binding constant for ERBB4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:208908",
"relation": "IDG (Drug Target)",
"target": "5298",
"properties": {
"id": "lapatinib targets PI4KB",
"source_label": "lapatinib",
"target_label": "PI4KB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "Binding constant for PIK4CB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:208908",
"relation": "IDG (Drug Target)",
"target": "5287",
"properties": {
"id": "lapatinib targets PIK3C2B",
"source_label": "lapatinib",
"target_label": "PIK3C2B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Binding constant for PIK3C2B kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311221",
"relation": "IDG (Drug Target)",
"target": "5737",
"properties": {
"id": "latanoprost targets PTGFR",
"source_label": "latanoprost",
"target_label": "PTGFR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3899",
"relation": "IDG (Drug Target)",
"target": "1544",
"properties": {
"id": "leflunomide targets CYP1A2",
"source_label": "leflunomide",
"target_label": "CYP1A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.301",
"act_comment": "DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3902",
"relation": "IDG (Drug Target)",
"target": "1588",
"properties": {
"id": "letrozole targets CYP19A1",
"source_label": "letrozole",
"target_label": "CYP19A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:657181",
"relation": "IDG (Drug Target)",
"target": "2798",
"properties": {
"id": "leuprorelin targets GNRHR",
"source_label": "leuprorelin",
"target_label": "GNRHR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.523",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5359371",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "levallorphan targets OPRM1",
"source_label": "levallorphan",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.32",
"act_comment": "Displacement of [125I]-IBOxyA from MOR-1 expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:32893",
"relation": "IDG (Drug Target)",
"target": "134864",
"properties": {
"id": "levamfetamine targets TAAR1",
"source_label": "levamfetamine",
"target_label": "TAAR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Activation of human TAAR1 expressed in human HEK293T cells assessed as cAMP accumulation after 10 mins by BRET assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284583",
"relation": "IDG (Drug Target)",
"target": "9900",
"properties": {
"id": "levetiracetam targets SV2A",
"source_label": "levetiracetam",
"target_label": "SV2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Mechanism of Action; CHEMBL1998; SINGLE PROTEIN",
"act_source": "CHEMBL"
}
},
{
"source": "CID:54385",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "levocabastine targets HRH1",
"source_label": "levocabastine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.279",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:54385",
"relation": "IDG (Drug Target)",
"target": "23620",
"properties": {
"id": "levocabastine targets NTSR2",
"source_label": "levocabastine",
"target_label": "NTSR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:1549000",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "levocetirizine targets HRH1",
"source_label": "levocetirizine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.95",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:13109",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "levonorgestrel targets NR3C1",
"source_label": "levonorgestrel",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.167",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:13109",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "levonorgestrel targets PGR",
"source_label": "levonorgestrel",
"target_label": "PGR",
"act_type": "ED50",
"act_relation": "=",
"act_value": "12.796",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:13109",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "levonorgestrel targets SHBG",
"source_label": "levonorgestrel",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.91",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:13109",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "levonorgestrel targets SLC6A4",
"source_label": "levonorgestrel",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.225",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5359272",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "levorphanol targets OPRD1",
"source_label": "levorphanol",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.38",
"act_comment": "Inhibition of [3H]naltrindole binding to opioid receptor delta 1 of Chinese hamster ovary membrane",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5359272",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "levorphanol targets OPRK1",
"source_label": "levorphanol",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.64",
"act_comment": "Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of Chinese hamster ovary membrane",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5359272",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "levorphanol targets OPRM1",
"source_label": "levorphanol",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.68",
"act_comment": "Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of Chinese hamster ovary membrane",
"act_source": "CHEMBL"
}
},
{
"source": "CID:688272",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "levosulpiride targets DRD2",
"source_label": "levosulpiride",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.29",
"act_comment": "In vitro displacement of [3H]spiperone from the recombinant human dopamine receptor D2 short form expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:688272",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "levosulpiride targets DRD3",
"source_label": "levosulpiride",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.06",
"act_comment": "In vitro displacement of [3H]spiperone from the cloned human dopamine receptor D3 stably expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3926",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "lidoflazine targets KCNH2",
"source_label": "lidoflazine",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "Inhibitory concentration against potassium channel HERG",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3926",
"relation": "IDG (Drug Target)",
"target": "2030",
"properties": {
"id": "lidoflazine targets SLC29A1",
"source_label": "lidoflazine",
"target_label": "SLC29A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Inhibition of ENT1 in human K562 cells by flow cytometric assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:727",
"relation": "IDG (Drug Target)",
"target": "2562",
"properties": {
"id": "lindane targets GABRB3",
"source_label": "lindane",
"target_label": "GABRB3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.05",
"act_comment": "Displacement of [3H]EBOB from recombinant Homo sapiens (human) GABA beta3 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:727",
"relation": "IDG (Drug Target)",
"target": "2569",
"properties": {
"id": "lindane targets GABRR1",
"source_label": "lindane",
"target_label": "GABRR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.04",
"act_comment": "Displacement of [3H]EBOB from recombinant Homo sapiens (human) GABA rho1 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5920",
"relation": "IDG (Drug Target)",
"target": "134",
"properties": {
"id": "liothyronine targets ADORA1",
"source_label": "liothyronine",
"target_label": "ADORA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5920",
"relation": "IDG (Drug Target)",
"target": "1559",
"properties": {
"id": "liothyronine targets CYP2C9",
"source_label": "liothyronine",
"target_label": "CYP2C9",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.301",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5920",
"relation": "IDG (Drug Target)",
"target": "2147",
"properties": {
"id": "liothyronine targets F2",
"source_label": "liothyronine",
"target_label": "F2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.92",
"act_comment": "Agonist activity at GST-labelled THRbeta ( 202 to 461 residues) (unknown origin) incubated for 2 hrs in presence SRC1-2 co-activator peptide by Alphascreen assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5920",
"relation": "IDG (Drug Target)",
"target": "5468",
"properties": {
"id": "liothyronine targets PPARG",
"source_label": "liothyronine",
"target_label": "PPARG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Binding affinity to recombinant PPARgamma LBD (unknown origin) by isothermal titration calorimetry",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5920",
"relation": "IDG (Drug Target)",
"target": "55145",
"properties": {
"id": "liothyronine targets THAP1",
"source_label": "liothyronine",
"target_label": "THAP1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5920",
"relation": "IDG (Drug Target)",
"target": "7067",
"properties": {
"id": "liothyronine targets THRA",
"source_label": "liothyronine",
"target_label": "THRA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "10.24",
"act_comment": "Displacement of [125I]T3 from human TRalpha receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5920",
"relation": "IDG (Drug Target)",
"target": "7068",
"properties": {
"id": "liothyronine targets THRB",
"source_label": "liothyronine",
"target_label": "THRB",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.1",
"act_comment": "Inhibitory activity against [125I]T3 binding to human TRbeta1 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5362119",
"relation": "IDG (Drug Target)",
"target": "1636",
"properties": {
"id": "lisinopril targets ACE",
"source_label": "lisinopril",
"target_label": "ACE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.92",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "lisuride targets ADRA1A",
"source_label": "lisuride",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "lisuride targets ADRA1D",
"source_label": "lisuride",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.037",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "lisuride targets ADRA2A",
"source_label": "lisuride",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.936",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "lisuride targets ADRA2B",
"source_label": "lisuride",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.625",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "lisuride targets ADRA2C",
"source_label": "lisuride",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.203",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "lisuride targets ADRB1",
"source_label": "lisuride",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.491",
"act_comment": "DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "lisuride targets ADRB2",
"source_label": "lisuride",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.538",
"act_comment": "DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "lisuride targets CYP2D6",
"source_label": "lisuride",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "lisuride targets DRD1",
"source_label": "lisuride",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.11",
"act_comment": "Affinity towards Dopamine receptor D1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "lisuride targets DRD2",
"source_label": "lisuride",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "Binding affinity towards Dopamine receptor D2 by displacement of [3H]U-86170.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "lisuride targets DRD3",
"source_label": "lisuride",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.77",
"act_comment": "Binding affinity towards Dopamine receptor D3 by displacement of [3H](+)-7-OH-DPAT.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "lisuride targets DRD4",
"source_label": "lisuride",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "lisuride targets DRD5",
"source_label": "lisuride",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "lisuride targets HRH1",
"source_label": "lisuride",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.721",
"act_comment": "DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "lisuride targets HTR1A",
"source_label": "lisuride",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "Binding affinity towards Serotonin 5-hydroxytryptamine 1A receptor by displacement of [3H]-(+)-8-OH-DPAT.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "lisuride targets HTR1B",
"source_label": "lisuride",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "lisuride targets HTR1D",
"source_label": "lisuride",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "lisuride targets HTR2A",
"source_label": "lisuride",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.061",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "lisuride targets HTR2B",
"source_label": "lisuride",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.489",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "lisuride targets HTR2C",
"source_label": "lisuride",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11957615",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "lisuride targets HTR6",
"source_label": "lisuride",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.259",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3947",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "lofepramine targets ADRA1A",
"source_label": "lofepramine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3947",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "lofepramine targets CHRM1",
"source_label": "lofepramine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.174",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3947",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "lofepramine targets CHRM2",
"source_label": "lofepramine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.481",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3947",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "lofepramine targets CHRM3",
"source_label": "lofepramine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.886",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3947",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "lofepramine targets CHRM4",
"source_label": "lofepramine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.468",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3947",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "lofepramine targets CHRM5",
"source_label": "lofepramine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.337",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3947",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "lofepramine targets HRH1",
"source_label": "lofepramine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.444",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3947",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "lofepramine targets HTR2C",
"source_label": "lofepramine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3947",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "lofepramine targets SLC6A2",
"source_label": "lofepramine",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.268",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3947",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "lofepramine targets SLC6A4",
"source_label": "lofepramine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.155",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:30668",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "lofexidine targets ADRA2A",
"source_label": "lofexidine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.36",
"act_comment": "Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:30668",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "lofexidine targets ADRA2B",
"source_label": "lofexidine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.17",
"act_comment": "Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:30668",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "lofexidine targets ADRA2C",
"source_label": "lofexidine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.16",
"act_comment": "Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2C expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:30668",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "lofexidine targets HTR1A",
"source_label": "lofexidine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells after 30 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3955",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "loperamide targets DRD3",
"source_label": "loperamide",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.343",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3955",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "loperamide targets OPRD1",
"source_label": "loperamide",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.91",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3955",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "loperamide targets OPRK1",
"source_label": "loperamide",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.81",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3955",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "loperamide targets OPRM1",
"source_label": "loperamide",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.824",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3955",
"relation": "IDG (Drug Target)",
"target": "6331",
"properties": {
"id": "loperamide targets SCN5A",
"source_label": "loperamide",
"target_label": "SCN5A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Inhibition of human Nav1.5 channel expressed in HEK293 cells at holding potential of -70 mV by whole cell patch clamp assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3955",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "loperamide targets SIGMAR1",
"source_label": "loperamide",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.578",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3957",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "loratadine targets CYP2C19",
"source_label": "loratadine",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3957",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "loratadine targets HRH1",
"source_label": "loratadine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.97",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3957",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "loratadine targets HTR2B",
"source_label": "loratadine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.807",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3957",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "loratadine targets KCNH2",
"source_label": "loratadine",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3961",
"relation": "IDG (Drug Target)",
"target": "1636",
"properties": {
"id": "losartan targets ACE",
"source_label": "losartan",
"target_label": "ACE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "Inhibitory activity against angiotensin I converting enzyme (ACE)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3961",
"relation": "IDG (Drug Target)",
"target": "185",
"properties": {
"id": "losartan targets AGTR1",
"source_label": "losartan",
"target_label": "AGTR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.48",
"act_comment": "Inhibition of angiotensin AT1 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:53232",
"relation": "IDG (Drug Target)",
"target": "338442",
"properties": {
"id": "lovastatin targets HCAR2",
"source_label": "lovastatin",
"target_label": "HCAR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:53232",
"relation": "IDG (Drug Target)",
"target": "8843",
"properties": {
"id": "lovastatin targets HCAR3",
"source_label": "lovastatin",
"target_label": "HCAR3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.53",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:53232",
"relation": "IDG (Drug Target)",
"target": "3156",
"properties": {
"id": "lovastatin targets HMGCR",
"source_label": "lovastatin",
"target_label": "HMGCR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.67",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:53232",
"relation": "IDG (Drug Target)",
"target": "8856",
"properties": {
"id": "lovastatin targets NR1I2",
"source_label": "lovastatin",
"target_label": "NR1I2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "loxapine targets ADRA1A",
"source_label": "loxapine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.509",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "loxapine targets ADRA1B",
"source_label": "loxapine",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.276",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "loxapine targets ADRA2A",
"source_label": "loxapine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.821",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "loxapine targets ADRA2B",
"source_label": "loxapine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.967",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "loxapine targets ADRA2C",
"source_label": "loxapine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.097",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "loxapine targets CHRM2",
"source_label": "loxapine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.376",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "loxapine targets CHRM3",
"source_label": "loxapine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.914",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "loxapine targets CHRM4",
"source_label": "loxapine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.087",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "loxapine targets CHRM5",
"source_label": "loxapine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.829",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "loxapine targets DRD1",
"source_label": "loxapine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.268",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "loxapine targets DRD2",
"source_label": "loxapine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.68",
"act_comment": "Affinity was evaluated by inhibition of [3H]spiperone binding to COS cells transfected with human dopamine D-2(long) receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "loxapine targets DRD3",
"source_label": "loxapine",
"target_label": "DRD3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.66",
"act_comment": "Binding affinity towards human Dopamine receptor D3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "loxapine targets DRD4",
"source_label": "loxapine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-4 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "loxapine targets DRD5",
"source_label": "loxapine",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.125",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "loxapine targets HRH1",
"source_label": "loxapine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "loxapine targets HRH2",
"source_label": "loxapine",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.682",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "loxapine targets HTR1B",
"source_label": "loxapine",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.411",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "loxapine targets HTR2A",
"source_label": "loxapine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.62",
"act_comment": "Displacement of [3H]ketanserin from human recombinant 5HT2A receptor expressed in CHO cells after 60 mins by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "loxapine targets HTR2C",
"source_label": "loxapine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "loxapine targets HTR3A",
"source_label": "loxapine",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.721",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "loxapine targets HTR5A",
"source_label": "loxapine",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3964",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "loxapine targets HTR6",
"source_label": "loxapine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.82",
"act_comment": "Binding affinity towards human 5-hydroxytryptamine 6 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60182",
"relation": "IDG (Drug Target)",
"target": "886",
"properties": {
"id": "loxiglumide targets CCKAR",
"source_label": "loxiglumide",
"target_label": "CCKAR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.71",
"act_comment": "Displacement of [111In]DTPA-Glu-Gly-[Tyr27(SO3H)]-CCK8 from human CCK1 receptor in A431 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:151166",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "lumiracoxib targets PTGS1",
"source_label": "lumiracoxib",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.15",
"act_comment": "Inhibition of COX1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:151166",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "lumiracoxib targets PTGS2",
"source_label": "lumiracoxib",
"target_label": "PTGS2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.49",
"act_comment": "Inhibition of human COX2 preincubated before addition of [1-14C]arachidonic acid",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5761",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "lysergide targets ADRB1",
"source_label": "lysergide",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Binding affinity towards Beta-1 adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5761",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "lysergide targets ADRB2",
"source_label": "lysergide",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "Binding affinity towards Beta-2 adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5761",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "lysergide targets DRD2",
"source_label": "lysergide",
"target_label": "DRD2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.979",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5761",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "lysergide targets DRD3",
"source_label": "lysergide",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5761",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "lysergide targets DRD4",
"source_label": "lysergide",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.25",
"act_comment": "Binding affinity towards Dopamine receptor D4",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5761",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "lysergide targets DRD5",
"source_label": "lysergide",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "Binding affinity towards Dopamine receptor D5",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5761",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "lysergide targets HTR1A",
"source_label": "lysergide",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.856",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5761",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "lysergide targets HTR1D",
"source_label": "lysergide",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.41",
"act_comment": "Binding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5761",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "lysergide targets HTR1E",
"source_label": "lysergide",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.03",
"act_comment": "Binding affinity towards 5-hydroxytryptamine 1E receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5761",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "lysergide targets HTR2A",
"source_label": "lysergide",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.12",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5761",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "lysergide targets HTR2B",
"source_label": "lysergide",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5761",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "lysergide targets HTR2C",
"source_label": "lysergide",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5761",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "lysergide targets HTR5A",
"source_label": "lysergide",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "Binding affinities towards 5-hydroxytryptamine 5A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5761",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "lysergide targets HTR6",
"source_label": "lysergide",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5761",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "lysergide targets HTR7",
"source_label": "lysergide",
"target_label": "HTR7",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "GRAC: human 5-HT7 radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3998",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "mafenide targets CA1",
"source_label": "mafenide",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3998",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "mafenide targets CA12",
"source_label": "mafenide",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.52",
"act_comment": "Inhibitory constant against catalytic domain of human carbonic anhydrase XII",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3998",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "mafenide targets CA2",
"source_label": "mafenide",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Inhibitory activity against human carbonic anhydrase II (hCA II) by using esterase assay method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3998",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "mafenide targets CA7",
"source_label": "mafenide",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.12",
"act_comment": "Ki value against human carbonic anhydrase VII",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3998",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "mafenide targets CA9",
"source_label": "mafenide",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.99",
"act_comment": "Inhibitory activity against human carbonic anhydrase IX (hCA IX) by using CO2 hydrase assay method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "maprotiline targets ADRA1A",
"source_label": "maprotiline",
"target_label": "ADRA1A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.854",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "maprotiline targets ADRA1D",
"source_label": "maprotiline",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.71",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "maprotiline targets ADRA2A",
"source_label": "maprotiline",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.165",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "maprotiline targets ADRA2B",
"source_label": "maprotiline",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.876",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "maprotiline targets ADRA2C",
"source_label": "maprotiline",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.355",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "maprotiline targets CHRM1",
"source_label": "maprotiline",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.845",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "maprotiline targets CHRM2",
"source_label": "maprotiline",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.164",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "maprotiline targets CHRM3",
"source_label": "maprotiline",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "maprotiline targets CHRM4",
"source_label": "maprotiline",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.237",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "maprotiline targets CHRM5",
"source_label": "maprotiline",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.939",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "maprotiline targets DRD1",
"source_label": "maprotiline",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.308",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "maprotiline targets DRD2",
"source_label": "maprotiline",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.177",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "maprotiline targets DRD3",
"source_label": "maprotiline",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.298",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "maprotiline targets DRD5",
"source_label": "maprotiline",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.367",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "maprotiline targets HRH1",
"source_label": "maprotiline",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.777",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "maprotiline targets HRH2",
"source_label": "maprotiline",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.406",
"act_comment": "DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "maprotiline targets HTR2A",
"source_label": "maprotiline",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.921",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "maprotiline targets HTR2B",
"source_label": "maprotiline",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.67",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "maprotiline targets HTR2C",
"source_label": "maprotiline",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.387",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "maprotiline targets HTR6",
"source_label": "maprotiline",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.383",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "maprotiline targets SLC6A2",
"source_label": "maprotiline",
"target_label": "SLC6A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.27",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4011",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "maprotiline targets SLC6A3",
"source_label": "maprotiline",
"target_label": "SLC6A3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:483407",
"relation": "IDG (Drug Target)",
"target": "1234",
"properties": {
"id": "maraviroc targets CCR5",
"source_label": "maraviroc",
"target_label": "CCR5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "Binding affinity to CCR5",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71398",
"relation": "IDG (Drug Target)",
"target": "239",
"properties": {
"id": "masoprocol targets ALOX12",
"source_label": "masoprocol",
"target_label": "ALOX12",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Inhibition of human platelet-type 12-lipoxygenase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71398",
"relation": "IDG (Drug Target)",
"target": "246",
"properties": {
"id": "masoprocol targets ALOX15",
"source_label": "masoprocol",
"target_label": "ALOX15",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Inhibitory activity against human reticulocyte 15-lipoxygenase (15-HLO)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71398",
"relation": "IDG (Drug Target)",
"target": "240",
"properties": {
"id": "masoprocol targets ALOX5",
"source_label": "masoprocol",
"target_label": "ALOX5",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "Inhibition of recombinant human 5-LOX in human PBML assessed as inhibition of A23187-induced LTB4 production preincubated for 15 mins measured after 15 mins by enzyme immunoassay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71398",
"relation": "IDG (Drug Target)",
"target": "1588",
"properties": {
"id": "masoprocol targets CYP19A1",
"source_label": "masoprocol",
"target_label": "CYP19A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Inhibition of human placental microsome CYP19",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71398",
"relation": "IDG (Drug Target)",
"target": "3294",
"properties": {
"id": "masoprocol targets HSD17B2",
"source_label": "masoprocol",
"target_label": "HSD17B2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation counting method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71398",
"relation": "IDG (Drug Target)",
"target": "3480",
"properties": {
"id": "masoprocol targets IGF1R",
"source_label": "masoprocol",
"target_label": "IGF1R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Inhibition of IGF1R",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71398",
"relation": "IDG (Drug Target)",
"target": "1241",
"properties": {
"id": "masoprocol targets LTB4R",
"source_label": "masoprocol",
"target_label": "LTB4R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.07",
"act_comment": "The compound was tested for its inhibitory activity against LTB4 in human PMN",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6398761",
"relation": "IDG (Drug Target)",
"target": "7421",
"properties": {
"id": "maxacalcitol targets VDR",
"source_label": "maxacalcitol",
"target_label": "VDR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.07",
"act_comment": "Activation of VDR in human Jurkat cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after 24 hrs by luciferase transcriptional reporter assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4020",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "mazindol targets HRH1",
"source_label": "mazindol",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.222",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4020",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "mazindol targets SIGMAR1",
"source_label": "mazindol",
"target_label": "SIGMAR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.63",
"act_comment": "The compound was tested for affinity towards sigma-3 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4020",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "mazindol targets SLC6A2",
"source_label": "mazindol",
"target_label": "SLC6A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "GRAC: human NET probe",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4020",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "mazindol targets SLC6A3",
"source_label": "mazindol",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "GRAC: human DAT selective inhibitor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4020",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "mazindol targets SLC6A4",
"source_label": "mazindol",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Displacement of [125I]- RTI-55 from Serotonin transporter expressed in HEK cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:73707357",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "mebhydrolin targets CHRM1",
"source_label": "mebhydrolin",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.745",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:73707357",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "mebhydrolin targets HRH1",
"source_label": "mebhydrolin",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.119",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:73707357",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "mebhydrolin targets HTR5A",
"source_label": "mebhydrolin",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.921",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4032",
"relation": "IDG (Drug Target)",
"target": "1136",
"properties": {
"id": "mecamylamine targets CHRNA3",
"source_label": "mecamylamine",
"target_label": "CHRNA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4032",
"relation": "IDG (Drug Target)",
"target": "1137",
"properties": {
"id": "mecamylamine targets CHRNA4",
"source_label": "mecamylamine",
"target_label": "CHRNA4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4034",
"relation": "IDG (Drug Target)",
"target": "9970",
"properties": {
"id": "meclozine targets NR1I3",
"source_label": "meclozine",
"target_label": "NR1I3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.16",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4037",
"relation": "IDG (Drug Target)",
"target": "8644",
"properties": {
"id": "meclofenamic acid targets AKR1C3",
"source_label": "meclofenamic acid",
"target_label": "AKR1C3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.27",
"act_comment": "Inhibition of human recombinant N-terminal His6-tagged AKR1C3 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-aza-benzo[de]anthracen-10-one as substrate after 1 hr by fluorimetric analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4037",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "meclofenamic acid targets PTGS1",
"source_label": "meclofenamic acid",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4037",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "meclofenamic acid targets PTGS2",
"source_label": "meclofenamic acid",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:41835",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "medroxalol targets ADRA1A",
"source_label": "medroxalol",
"target_label": "ADRA1A",
"act_type": "pA2",
"act_relation": "=",
"act_value": "6.08",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:41835",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "medroxalol targets ADRB1",
"source_label": "medroxalol",
"target_label": "ADRB1",
"act_type": "pA2",
"act_relation": "=",
"act_value": "7.82",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6279",
"relation": "IDG (Drug Target)",
"target": "8644",
"properties": {
"id": "medroxyprogesterone targets AKR1C3",
"source_label": "medroxyprogesterone",
"target_label": "AKR1C3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Inhibition of recombinant AKR1C3 (unknown origin) assessed as decrease in oxidation of 1-acenaphthenol substrate by spectrophotometric analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6279",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "medroxyprogesterone targets AR",
"source_label": "medroxyprogesterone",
"target_label": "AR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6279",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "medroxyprogesterone targets NR3C1",
"source_label": "medroxyprogesterone",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.88",
"act_comment": "Inhibition of Dexamethasone binding to human glucocorticoid receptor expressed in baculovirus SF-12 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6279",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "medroxyprogesterone targets PGR",
"source_label": "medroxyprogesterone",
"target_label": "PGR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.59",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6279",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "medroxyprogesterone targets SHBG",
"source_label": "medroxyprogesterone",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4044",
"relation": "IDG (Drug Target)",
"target": "1645",
"properties": {
"id": "mefenamic acid targets AKR1C1",
"source_label": "mefenamic acid",
"target_label": "AKR1C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Inhibition of human recombinant AKR1C1 assessed as 1-acenaphthenol oxidation by spectrophotometry",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4044",
"relation": "IDG (Drug Target)",
"target": "1646",
"properties": {
"id": "mefenamic acid targets AKR1C2",
"source_label": "mefenamic acid",
"target_label": "AKR1C2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Inhibition of human recombinant AKR1C2 assessed as 1-acenaphthenol oxidation by spectrophotometry",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4044",
"relation": "IDG (Drug Target)",
"target": "8644",
"properties": {
"id": "mefenamic acid targets AKR1C3",
"source_label": "mefenamic acid",
"target_label": "AKR1C3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Inhibition of human recombinant AKR1C3 assessed as 1-acenaphthenol oxidation by spectrophotometry",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4044",
"relation": "IDG (Drug Target)",
"target": "4353",
"properties": {
"id": "mefenamic acid targets MPO",
"source_label": "mefenamic acid",
"target_label": "MPO",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed by H2O2 addition measured after 5 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4044",
"relation": "IDG (Drug Target)",
"target": "93100",
"properties": {
"id": "mefenamic acid targets NAPRT",
"source_label": "mefenamic acid",
"target_label": "NAPRT",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.3",
"act_comment": "Inhibition of NAPRT (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4044",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "mefenamic acid targets PTGS2",
"source_label": "mefenamic acid",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.83",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:40692",
"relation": "IDG (Drug Target)",
"target": "135",
"properties": {
"id": "mefloquine targets ADORA2A",
"source_label": "mefloquine",
"target_label": "ADORA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.91",
"act_comment": "Binding affinity to human adenosine A2A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11683",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "megestrol acetate targets NR3C1",
"source_label": "megestrol acetate",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.057",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1662",
"relation": "IDG (Drug Target)",
"target": "3156",
"properties": {
"id": "meglutol targets HMGCR",
"source_label": "meglutol",
"target_label": "HMGCR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.63",
"act_comment": "Inhibitory constant against HMG-CoA reductase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:896",
"relation": "IDG (Drug Target)",
"target": "11255",
"properties": {
"id": "melatonin targets HRH3",
"source_label": "melatonin",
"target_label": "HRH3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "Displacement of [3H]-N-alpha-methylhistamine from human H3 receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:896",
"relation": "IDG (Drug Target)",
"target": "4543",
"properties": {
"id": "melatonin targets MTNR1A",
"source_label": "melatonin",
"target_label": "MTNR1A",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:896",
"relation": "IDG (Drug Target)",
"target": "4544",
"properties": {
"id": "melatonin targets MTNR1B",
"source_label": "melatonin",
"target_label": "MTNR1B",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:896",
"relation": "IDG (Drug Target)",
"target": "4835",
"properties": {
"id": "melatonin targets NQO2",
"source_label": "melatonin",
"target_label": "NQO2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.56",
"act_comment": "Ability to inhibit 2-[125I]iodomelatonin specific binding to melatonin receptor 3 (MT3) of Syrian hamster brain.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:896",
"relation": "IDG (Drug Target)",
"target": "6095",
"properties": {
"id": "melatonin targets RORA",
"source_label": "melatonin",
"target_label": "RORA",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:10291556",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "meloxicam targets PTGS2",
"source_label": "meloxicam",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "Concentration that caused a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 2 activity as measured by PGE-2 production.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:15387",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "melperone targets ADRA1A",
"source_label": "melperone",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:15387",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "melperone targets ADRA2A",
"source_label": "melperone",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:15387",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "melperone targets DRD2",
"source_label": "melperone",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.979",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:15387",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "melperone targets DRD3",
"source_label": "melperone",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.063",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:15387",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "melperone targets DRD4",
"source_label": "melperone",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.387",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:15387",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "melperone targets HRH1",
"source_label": "melperone",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.237",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:15387",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "melperone targets HTR2A",
"source_label": "melperone",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.717",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4055",
"relation": "IDG (Drug Target)",
"target": "3620",
"properties": {
"id": "menadione targets IDO1",
"source_label": "menadione",
"target_label": "IDO1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Inhibition of purified human recombinant IDO",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4055",
"relation": "IDG (Drug Target)",
"target": "4129",
"properties": {
"id": "menadione targets MAOB",
"source_label": "menadione",
"target_label": "MAOB",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Competitive inhibition of human recombinant MAO-B expressed in baculovirus infected insect cells using benzylamine as substrate by Lineweaver-Burk plot analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6075",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "pecazine targets ADRA1D",
"source_label": "pecazine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.237",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6075",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "pecazine targets ADRA2A",
"source_label": "pecazine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.263",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6075",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "pecazine targets ADRA2B",
"source_label": "pecazine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.742",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6075",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "pecazine targets CHRM1",
"source_label": "pecazine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.721",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6075",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "pecazine targets CHRM2",
"source_label": "pecazine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.697",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6075",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "pecazine targets CHRM3",
"source_label": "pecazine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.398",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6075",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "pecazine targets CHRM4",
"source_label": "pecazine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.721",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6075",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "pecazine targets CHRM5",
"source_label": "pecazine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.553",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6075",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "pecazine targets DRD3",
"source_label": "pecazine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.167",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6075",
"relation": "IDG (Drug Target)",
"target": "2671",
"properties": {
"id": "pecazine targets GFER",
"source_label": "pecazine",
"target_label": "GFER",
"act_type": "AC50",
"act_relation": "=",
"act_value": "7.01",
"act_comment": "PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787]",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6075",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "pecazine targets HRH1",
"source_label": "pecazine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.504",
"act_comment": "DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6075",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "pecazine targets HTR2A",
"source_label": "pecazine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.959",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6075",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "pecazine targets HTR2B",
"source_label": "pecazine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.485",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6075",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "pecazine targets HTR2C",
"source_label": "pecazine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.587",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6075",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "pecazine targets HTR6",
"source_label": "pecazine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.069",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6075",
"relation": "IDG (Drug Target)",
"target": "10892",
"properties": {
"id": "pecazine targets MALT1",
"source_label": "pecazine",
"target_label": "MALT1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Inhibition of GST-MALT1 (325 to 760 residues) (unknown origin) using Ac-LRSR-AMC as substrate by fluorescence analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6075",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "pecazine targets SIGMAR1",
"source_label": "pecazine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.119",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4057",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "mepenzolate targets CHRM2",
"source_label": "mepenzolate",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.17",
"act_comment": "Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4057",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "mepenzolate targets CHRM3",
"source_label": "mepenzolate",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.59",
"act_comment": "Displacement of [3H]NMS from human M3R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4058",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "pethidine targets KCNH2",
"source_label": "pethidine",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.49",
"act_comment": "Inhibitory concentration against potassium channel HERG",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4058",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "pethidine targets OPRM1",
"source_label": "pethidine",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "Inhibition of [3H]DAMGO binding to mu-opioid receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4064",
"relation": "IDG (Drug Target)",
"target": "5243",
"properties": {
"id": "meprobamate targets ABCB1",
"source_label": "meprobamate",
"target_label": "ABCB1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.821",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:41049",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "meptazinol targets OPRM1",
"source_label": "meptazinol",
"target_label": "OPRM1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.06",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4066",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "mequitazine targets HRH1",
"source_label": "mequitazine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.237",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4078",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "mesoridazine targets CHRM1",
"source_label": "mesoridazine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4078",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "mesoridazine targets CHRM2",
"source_label": "mesoridazine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.824",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4078",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "mesoridazine targets CHRM3",
"source_label": "mesoridazine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.046",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4078",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "mesoridazine targets CHRM4",
"source_label": "mesoridazine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.721",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4078",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "mesoridazine targets CHRM5",
"source_label": "mesoridazine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.222",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4078",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "mesoridazine targets DRD1",
"source_label": "mesoridazine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.99",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4078",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "mesoridazine targets DRD2",
"source_label": "mesoridazine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.724",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4078",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "mesoridazine targets DRD3",
"source_label": "mesoridazine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.585",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4078",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "mesoridazine targets DRD4",
"source_label": "mesoridazine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.041",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4078",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "mesoridazine targets HRH1",
"source_label": "mesoridazine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.744",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4078",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "mesoridazine targets HTR1A",
"source_label": "mesoridazine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.98",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4078",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "mesoridazine targets HTR2A",
"source_label": "mesoridazine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.125",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4078",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "mesoridazine targets HTR2C",
"source_label": "mesoridazine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.804",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4078",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "mesoridazine targets HTR6",
"source_label": "mesoridazine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4078",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "mesoridazine targets KCNH2",
"source_label": "mesoridazine",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "Inhibition of human ERG",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6291",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "mestranol targets ESR1",
"source_label": "mestranol",
"target_label": "ESR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.282",
"act_comment": "DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6291",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "mestranol targets SLC6A4",
"source_label": "mestranol",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.658",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4086",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "orciprenaline targets ADRB2",
"source_label": "orciprenaline",
"target_label": "ADRB2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Binding affinity to beta-2 adrenergic receptor (unknown origin) at 1 to 10000 nM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "metergoline targets ADRA1D",
"source_label": "metergoline",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "metergoline targets ADRA2A",
"source_label": "metergoline",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.658",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "metergoline targets ADRA2B",
"source_label": "metergoline",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.124",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "metergoline targets ADRA2C",
"source_label": "metergoline",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.569",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "metergoline targets CYP2D6",
"source_label": "metergoline",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.699",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "metergoline targets DRD1",
"source_label": "metergoline",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.432",
"act_comment": "DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "metergoline targets DRD2",
"source_label": "metergoline",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.678",
"act_comment": "DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "metergoline targets DRD3",
"source_label": "metergoline",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.583",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "metergoline targets HRH1",
"source_label": "metergoline",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.319",
"act_comment": "DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "metergoline targets HRH2",
"source_label": "metergoline",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.018",
"act_comment": "DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "metergoline targets HTR1A",
"source_label": "metergoline",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.64",
"act_comment": "Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHOK1 cells after 60 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "metergoline targets HTR1B",
"source_label": "metergoline",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "metergoline targets HTR1D",
"source_label": "metergoline",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "metergoline targets HTR1E",
"source_label": "metergoline",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "metergoline targets HTR1F",
"source_label": "metergoline",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "metergoline targets HTR2A",
"source_label": "metergoline",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "metergoline targets HTR2B",
"source_label": "metergoline",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "metergoline targets HTR2C",
"source_label": "metergoline",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "Evaluated for the binding affinity to porcine choroid plexus at 5-hydroxytryptamine 2C receptor binding site by using [3H]-MES as a radioligand.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "metergoline targets HTR5A",
"source_label": "metergoline",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "metergoline targets HTR6",
"source_label": "metergoline",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "metergoline targets HTR7",
"source_label": "metergoline",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "Displacement of [3H]5CT from 5HT7 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "metergoline targets SLC6A2",
"source_label": "metergoline",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "metergoline targets SLC6A3",
"source_label": "metergoline",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.301",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:28693",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "metergoline targets SLC6A4",
"source_label": "metergoline",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.504",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1993",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "methacholine targets CHRM1",
"source_label": "methacholine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.638",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:1993",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "methacholine targets CHRM2",
"source_label": "methacholine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.23",
"act_comment": "Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4095",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "methadone targets OPRK1",
"source_label": "methadone",
"target_label": "OPRK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "Binding affinity against opioid receptor kappa 1 using [3H]- U-69,593 radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4095",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "methadone targets OPRM1",
"source_label": "methadone",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.78",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:10836",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "methamphetamine targets ADRA2B",
"source_label": "methamphetamine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.128",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:10836",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "methamphetamine targets ADRA2C",
"source_label": "methamphetamine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:10836",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "methamphetamine targets SLC6A3",
"source_label": "methamphetamine",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.611",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:10836",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "methamphetamine targets SLC6A4",
"source_label": "methamphetamine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.133",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4098",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "methapyrilene targets ADRA2A",
"source_label": "methapyrilene",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4098",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "methapyrilene targets CHRM2",
"source_label": "methapyrilene",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.228",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4098",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "methapyrilene targets HRH1",
"source_label": "methapyrilene",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.745",
"act_comment": "DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4098",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "methapyrilene targets HTR2A",
"source_label": "methapyrilene",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.745",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4098",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "methapyrilene targets HTR2B",
"source_label": "methapyrilene",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.27",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4098",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "methapyrilene targets HTR2C",
"source_label": "methapyrilene",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.409",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4098",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "methapyrilene targets SLC6A4",
"source_label": "methapyrilene",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.975",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4100",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "methazolamide targets CA1",
"source_label": "methazolamide",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4100",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "methazolamide targets CA12",
"source_label": "methazolamide",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.47",
"act_comment": "Ki value against human carbonic anhydrase XII (hCA XII)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4100",
"relation": "IDG (Drug Target)",
"target": "377677",
"properties": {
"id": "methazolamide targets CA13",
"source_label": "methazolamide",
"target_label": "CA13",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "Inhibition of human recombinant cytosolic carbonic anhydrase 13 preincubated for 15 mins by stopped-flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4100",
"relation": "IDG (Drug Target)",
"target": "23632",
"properties": {
"id": "methazolamide targets CA14",
"source_label": "methazolamide",
"target_label": "CA14",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.37",
"act_comment": "Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4100",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "methazolamide targets CA2",
"source_label": "methazolamide",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "Inhibitory activity against human carbonic anhydrase II",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4100",
"relation": "IDG (Drug Target)",
"target": "761",
"properties": {
"id": "methazolamide targets CA3",
"source_label": "methazolamide",
"target_label": "CA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.96",
"act_comment": "Inhibition of human carbonic anhydrase 3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4100",
"relation": "IDG (Drug Target)",
"target": "762",
"properties": {
"id": "methazolamide targets CA4",
"source_label": "methazolamide",
"target_label": "CA4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Inhibition of cloned isozyme, human carbonic anhydrase IV",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4100",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "methazolamide targets CA5A",
"source_label": "methazolamide",
"target_label": "CA5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.19",
"act_comment": "Inhibitory activity against human recombinant mitochondrial isozyme CA VA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4100",
"relation": "IDG (Drug Target)",
"target": "11238",
"properties": {
"id": "methazolamide targets CA5B",
"source_label": "methazolamide",
"target_label": "CA5B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.21",
"act_comment": "Inhibitory activity against human recombinant mitochondrial isozyme CA VB",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4100",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "methazolamide targets CA6",
"source_label": "methazolamide",
"target_label": "CA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Inhibition of full length human recombinant CA VI",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4100",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "methazolamide targets CA7",
"source_label": "methazolamide",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.68",
"act_comment": "Ki value against human carbonic anhydrase VII",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4100",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "methazolamide targets CA9",
"source_label": "methazolamide",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.57",
"act_comment": "Inhibitory activity against human carbonic anhydrase IX (hCA IX) by using CO2 hydrase assay method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4107",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "methocarbamol targets CA1",
"source_label": "methocarbamol",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4112",
"relation": "IDG (Drug Target)",
"target": "1719",
"properties": {
"id": "methotrexate targets DHFR",
"source_label": "methotrexate",
"target_label": "DHFR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.92",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4112",
"relation": "IDG (Drug Target)",
"target": "2348",
"properties": {
"id": "methotrexate targets FOLR1",
"source_label": "methotrexate",
"target_label": "FOLR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.94",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4112",
"relation": "IDG (Drug Target)",
"target": "2350",
"properties": {
"id": "methotrexate targets FOLR2",
"source_label": "methotrexate",
"target_label": "FOLR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.97",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4112",
"relation": "IDG (Drug Target)",
"target": "3146",
"properties": {
"id": "methotrexate targets HMGB1",
"source_label": "methotrexate",
"target_label": "HMGB1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.62",
"act_comment": "Binding affinity to N-terminal 6His-tagged HMGB1 Bj region (88 to 181 residues) (unknown origin) expressed in Escherichia coli JM109 by SPR assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4112",
"relation": "IDG (Drug Target)",
"target": "113235",
"properties": {
"id": "methotrexate targets SLC46A1",
"source_label": "methotrexate",
"target_label": "SLC46A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4112",
"relation": "IDG (Drug Target)",
"target": "7298",
"properties": {
"id": "methotrexate targets TYMS",
"source_label": "methotrexate",
"target_label": "TYMS",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Inhibition of human TS by spectrophotometric analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:72287",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "levomepromazine targets HRH1",
"source_label": "levomepromazine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.237",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:71183",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "methscopolamine targets CHRM1",
"source_label": "methscopolamine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:71183",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "methscopolamine targets CHRM2",
"source_label": "methscopolamine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.82",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71183",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "methscopolamine targets CHRM3",
"source_label": "methscopolamine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:71183",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "methscopolamine targets CHRM4",
"source_label": "methscopolamine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.01",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71183",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "methscopolamine targets CHRM5",
"source_label": "methscopolamine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.68",
"act_comment": "Displacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO cells after 120 mins by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4139",
"relation": "IDG (Drug Target)",
"target": "351",
"properties": {
"id": "methylthioninium chloride targets APP",
"source_label": "methylthioninium chloride",
"target_label": "APP",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4139",
"relation": "IDG (Drug Target)",
"target": "4128",
"properties": {
"id": "methylthioninium chloride targets MAOA",
"source_label": "methylthioninium chloride",
"target_label": "MAOA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:8226",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "methylergometrine targets ADRA2A",
"source_label": "methylergometrine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.225",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:8226",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "methylergometrine targets ADRA2B",
"source_label": "methylergometrine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.678",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:8226",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "methylergometrine targets CYP2D6",
"source_label": "methylergometrine",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.699",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:8226",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "methylergometrine targets DRD1",
"source_label": "methylergometrine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.268",
"act_comment": "DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:8226",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "methylergometrine targets DRD2",
"source_label": "methylergometrine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.559",
"act_comment": "DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:8226",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "methylergometrine targets DRD3",
"source_label": "methylergometrine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.244",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:8226",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "methylergometrine targets HTR1A",
"source_label": "methylergometrine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.633",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:8226",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "methylergometrine targets HTR1E",
"source_label": "methylergometrine",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:8226",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "methylergometrine targets HTR1F",
"source_label": "methylergometrine",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:8226",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "methylergometrine targets HTR2A",
"source_label": "methylergometrine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:8226",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "methylergometrine targets HTR2B",
"source_label": "methylergometrine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:8226",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "methylergometrine targets HTR2C",
"source_label": "methylergometrine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:8226",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "methylergometrine targets HTR6",
"source_label": "methylergometrine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.928",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5360515",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "naltrexone targets CYP2D6",
"source_label": "naltrexone",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5360515",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "naltrexone targets OPRD1",
"source_label": "naltrexone",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.99",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5360515",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "naltrexone targets OPRK1",
"source_label": "naltrexone",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.93",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5360515",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "naltrexone targets OPRM1",
"source_label": "naltrexone",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.38",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:7456",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "methylparaben targets CA12",
"source_label": "methylparaben",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:7456",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "methylparaben targets CA7",
"source_label": "methylparaben",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Inhibition of human carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration stopped-flow assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4158",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "methylphenidate targets ADRA2C",
"source_label": "methylphenidate",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.068",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4158",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "methylphenidate targets SLC6A2",
"source_label": "methylphenidate",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.18",
"act_comment": "Displacement of [125I]RTI-55 from human NET expressing HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4158",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "methylphenidate targets SLC6A3",
"source_label": "methylphenidate",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Displacement of [125I]RTI-55 from human DAT expressing HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44483298",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "methylprednisolone targets NR3C1",
"source_label": "methylprednisolone",
"target_label": "NR3C1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9681",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "methysergide targets ADRA2A",
"source_label": "methysergide",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.214",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:9681",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "methysergide targets DRD1",
"source_label": "methysergide",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.326",
"act_comment": "DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:9681",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "methysergide targets DRD2",
"source_label": "methysergide",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:9681",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "methysergide targets DRD3",
"source_label": "methysergide",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.229",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:9681",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "methysergide targets HTR1A",
"source_label": "methysergide",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.509",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:9681",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "methysergide targets HTR1B",
"source_label": "methysergide",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9681",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "methysergide targets HTR1D",
"source_label": "methysergide",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9681",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "methysergide targets HTR1E",
"source_label": "methysergide",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9681",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "methysergide targets HTR1F",
"source_label": "methysergide",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9681",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "methysergide targets HTR2A",
"source_label": "methysergide",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.45",
"act_comment": "Displacement of [3H]ketanserin from human 5HT2AR expressed in HEK-293 cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9681",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "methysergide targets HTR2B",
"source_label": "methysergide",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.34",
"act_comment": "Displacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9681",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "methysergide targets HTR2C",
"source_label": "methysergide",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.34",
"act_comment": "Displacement of [3H]mesulergine from human HTR2B expressed in HEK-293 cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9681",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "methysergide targets HTR5A",
"source_label": "methysergide",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9681",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "methysergide targets HTR6",
"source_label": "methysergide",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9681",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "methysergide targets HTR7",
"source_label": "methysergide",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9681",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "methysergide targets SIGMAR1",
"source_label": "methysergide",
"target_label": "SIGMAR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "The compound was tested for affinity towards sigma-3 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4168",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "metoclopramide targets CYP2D6",
"source_label": "metoclopramide",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.097",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4168",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "metoclopramide targets DRD2",
"source_label": "metoclopramide",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.194",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4168",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "metoclopramide targets DRD3",
"source_label": "metoclopramide",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.66",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4168",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "metoclopramide targets HTR2B",
"source_label": "metoclopramide",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.397",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4168",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "metoclopramide targets HTR3A",
"source_label": "metoclopramide",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.699",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4168",
"relation": "IDG (Drug Target)",
"target": "3360",
"properties": {
"id": "metoclopramide targets HTR4",
"source_label": "metoclopramide",
"target_label": "HTR4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4168",
"relation": "IDG (Drug Target)",
"target": "4353",
"properties": {
"id": "metoclopramide targets MPO",
"source_label": "metoclopramide",
"target_label": "MPO",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed by H2O2 addition measured after 5 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4170",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "metolazone targets CA7",
"source_label": "metolazone",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.68",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4170",
"relation": "IDG (Drug Target)",
"target": "6557",
"properties": {
"id": "metolazone targets SLC12A1",
"source_label": "metolazone",
"target_label": "SLC12A1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.45",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:26388",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "metopimazine targets DRD2",
"source_label": "metopimazine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.15",
"act_comment": "Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:26388",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "metopimazine targets DRD3",
"source_label": "metopimazine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.21",
"act_comment": "Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:26388",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "metopimazine targets HRH1",
"source_label": "metopimazine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.08",
"act_comment": "Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4171",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "metoprolol targets ADRB1",
"source_label": "metoprolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4171",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "metoprolol targets ADRB2",
"source_label": "metoprolol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4174",
"relation": "IDG (Drug Target)",
"target": "1584",
"properties": {
"id": "metyrapone targets CYP11B1",
"source_label": "metyrapone",
"target_label": "CYP11B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.84",
"act_comment": "Inhibition of human steroid-11beta-hydroxylase expressed in chinese hamster V79 cells using 11-deoxycorticosterone as substrate",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4174",
"relation": "IDG (Drug Target)",
"target": "1585",
"properties": {
"id": "metyrapone targets CYP11B2",
"source_label": "metyrapone",
"target_label": "CYP11B2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.38",
"act_comment": "Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrate",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4174",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "metyrapone targets CYP3A4",
"source_label": "metyrapone",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.097",
"act_comment": "DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4178",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "mexiletine targets HTR2B",
"source_label": "mexiletine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:656511",
"relation": "IDG (Drug Target)",
"target": "8644",
"properties": {
"id": "mezlocillin targets AKR1C3",
"source_label": "mezlocillin",
"target_label": "AKR1C3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:656511",
"relation": "IDG (Drug Target)",
"target": "3576",
"properties": {
"id": "mezlocillin targets CXCL8",
"source_label": "mezlocillin",
"target_label": "CXCL8",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:656511",
"relation": "IDG (Drug Target)",
"target": "1558",
"properties": {
"id": "mezlocillin targets CYP2C8",
"source_label": "mezlocillin",
"target_label": "CYP2C8",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:656511",
"relation": "IDG (Drug Target)",
"target": "3554",
"properties": {
"id": "mezlocillin targets IL1R1",
"source_label": "mezlocillin",
"target_label": "IL1R1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:656511",
"relation": "IDG (Drug Target)",
"target": "11251",
"properties": {
"id": "mezlocillin targets PTGDR2",
"source_label": "mezlocillin",
"target_label": "PTGDR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:656511",
"relation": "IDG (Drug Target)",
"target": "5730",
"properties": {
"id": "mezlocillin targets PTGDS",
"source_label": "mezlocillin",
"target_label": "PTGDS",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:656511",
"relation": "IDG (Drug Target)",
"target": "5732",
"properties": {
"id": "mezlocillin targets PTGER2",
"source_label": "mezlocillin",
"target_label": "PTGER2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:656511",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "mezlocillin targets PTGS1",
"source_label": "mezlocillin",
"target_label": "PTGS1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:656511",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "mezlocillin targets PTGS2",
"source_label": "mezlocillin",
"target_label": "PTGS2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "mianserin targets ADRA1A",
"source_label": "mianserin",
"target_label": "ADRA1A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "Binding affinity for human cloned Alpha-1A adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "mianserin targets ADRA1B",
"source_label": "mianserin",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "mianserin targets ADRA1D",
"source_label": "mianserin",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "mianserin targets ADRA2A",
"source_label": "mianserin",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.319",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "mianserin targets ADRA2B",
"source_label": "mianserin",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.569",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "mianserin targets ADRA2C",
"source_label": "mianserin",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.42",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "mianserin targets CHRM1",
"source_label": "mianserin",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.465",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "mianserin targets CHRM2",
"source_label": "mianserin",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.417",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "mianserin targets CHRM3",
"source_label": "mianserin",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.526",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "mianserin targets CHRM4",
"source_label": "mianserin",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.541",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "mianserin targets CHRM5",
"source_label": "mianserin",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.638",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "mianserin targets DRD1",
"source_label": "mianserin",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "mianserin targets HRH1",
"source_label": "mianserin",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.245",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "mianserin targets HRH2",
"source_label": "mianserin",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.003",
"act_comment": "DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "59340",
"properties": {
"id": "mianserin targets HRH4",
"source_label": "mianserin",
"target_label": "HRH4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.125",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "mianserin targets HTR1A",
"source_label": "mianserin",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "mianserin targets HTR1B",
"source_label": "mianserin",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.53",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "mianserin targets HTR1D",
"source_label": "mianserin",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.99",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "mianserin targets HTR1F",
"source_label": "mianserin",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.06",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "mianserin targets HTR2A",
"source_label": "mianserin",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.17",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "mianserin targets HTR2B",
"source_label": "mianserin",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.12",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "mianserin targets HTR2C",
"source_label": "mianserin",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "mianserin targets HTR3A",
"source_label": "mianserin",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT3 radioligand binding (ligand: [3H] GR-65630)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "mianserin targets HTR6",
"source_label": "mianserin",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.175",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "mianserin targets HTR7",
"source_label": "mianserin",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.06",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4184",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "mianserin targets SLC6A2",
"source_label": "mianserin",
"target_label": "SLC6A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.149",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60663",
"relation": "IDG (Drug Target)",
"target": "8913",
"properties": {
"id": "mibefradil targets CACNA1G",
"source_label": "mibefradil",
"target_label": "CACNA1G",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Inhibition of human Cav3.1 alpha1G expressed in HEK293 cells assessed as inhibition of calcium influx by FLIPR assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60663",
"relation": "IDG (Drug Target)",
"target": "8912",
"properties": {
"id": "mibefradil targets CACNA1H",
"source_label": "mibefradil",
"target_label": "CACNA1H",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.602",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60663",
"relation": "IDG (Drug Target)",
"target": "8911",
"properties": {
"id": "mibefradil targets CACNA1I",
"source_label": "mibefradil",
"target_label": "CACNA1I",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "Inhibition of T-type calcium channel alpha1I by FLIPR",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60663",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "mibefradil targets CYP3A4",
"source_label": "mibefradil",
"target_label": "CYP3A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60663",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "mibefradil targets KCNH2",
"source_label": "mibefradil",
"target_label": "KCNH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60663",
"relation": "IDG (Drug Target)",
"target": "6331",
"properties": {
"id": "mibefradil targets SCN5A",
"source_label": "mibefradil",
"target_label": "SCN5A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Inhibition of human heart Nav1.5 expressed in HEK293 cells by whole cell voltage clamp method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60663",
"relation": "IDG (Drug Target)",
"target": "6335",
"properties": {
"id": "mibefradil targets SCN9A",
"source_label": "mibefradil",
"target_label": "SCN9A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell voltage clamp method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4189",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "miconazole targets CHRM1",
"source_label": "miconazole",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4189",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "miconazole targets CHRM3",
"source_label": "miconazole",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.175",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4189",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "miconazole targets CHRM4",
"source_label": "miconazole",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.351",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4189",
"relation": "IDG (Drug Target)",
"target": "1586",
"properties": {
"id": "miconazole targets CYP17A1",
"source_label": "miconazole",
"target_label": "CYP17A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.61",
"act_comment": "In vitro inhibition of human Cytochrome P450 17A1 activity",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4189",
"relation": "IDG (Drug Target)",
"target": "1588",
"properties": {
"id": "miconazole targets CYP19A1",
"source_label": "miconazole",
"target_label": "CYP19A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Inhibition of human placental microsome CYP19",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4189",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "miconazole targets CYP2C19",
"source_label": "miconazole",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4189",
"relation": "IDG (Drug Target)",
"target": "1559",
"properties": {
"id": "miconazole targets CYP2C9",
"source_label": "miconazole",
"target_label": "CYP2C9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.699",
"act_comment": "DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4189",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "miconazole targets CYP2D6",
"source_label": "miconazole",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4189",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "miconazole targets CYP3A4",
"source_label": "miconazole",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4189",
"relation": "IDG (Drug Target)",
"target": "1595",
"properties": {
"id": "miconazole targets CYP51A1",
"source_label": "miconazole",
"target_label": "CYP51A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4189",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "miconazole targets SLC6A4",
"source_label": "miconazole",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.383",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4189",
"relation": "IDG (Drug Target)",
"target": "6916",
"properties": {
"id": "miconazole targets TBXAS1",
"source_label": "miconazole",
"target_label": "TBXAS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.58",
"act_comment": "DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4192",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "midazolam targets CYP3A4",
"source_label": "midazolam",
"target_label": "CYP3A4",
"act_type": "Km",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4195",
"relation": "IDG (Drug Target)",
"target": "3320",
"properties": {
"id": "midodrine targets HSP90AA1",
"source_label": "midodrine",
"target_label": "HSP90AA1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.699",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:55245",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "mifepristone targets AR",
"source_label": "mifepristone",
"target_label": "AR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.33",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:55245",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "mifepristone targets CYP3A4",
"source_label": "mifepristone",
"target_label": "CYP3A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:55245",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "mifepristone targets NR3C1",
"source_label": "mifepristone",
"target_label": "NR3C1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:55245",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "mifepristone targets OPRM1",
"source_label": "mifepristone",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.001",
"act_comment": "DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:55245",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "mifepristone targets PGR",
"source_label": "mifepristone",
"target_label": "PGR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.74",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:441314",
"relation": "IDG (Drug Target)",
"target": "2548",
"properties": {
"id": "miglitol targets GAA",
"source_label": "miglitol",
"target_label": "GAA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Inhibition of human lysosomal alpha-glucosidase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:441314",
"relation": "IDG (Drug Target)",
"target": "8972",
"properties": {
"id": "miglitol targets MGAM",
"source_label": "miglitol",
"target_label": "MGAM",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:441314",
"relation": "IDG (Drug Target)",
"target": "6476",
"properties": {
"id": "miglitol targets SI",
"source_label": "miglitol",
"target_label": "SI",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Inhibition of sucrase by HPLC",
"act_source": "CHEMBL"
}
},
{
"source": "CID:51634",
"relation": "IDG (Drug Target)",
"target": "2548",
"properties": {
"id": "miglustat targets GAA",
"source_label": "miglustat",
"target_label": "GAA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Inhibition of human lysosomal alpha glucosidase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:51634",
"relation": "IDG (Drug Target)",
"target": "57704",
"properties": {
"id": "miglustat targets GBA2",
"source_label": "miglustat",
"target_label": "GBA2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Inhibition of human GBA2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:51634",
"relation": "IDG (Drug Target)",
"target": "6476",
"properties": {
"id": "miglustat targets SI",
"source_label": "miglustat",
"target_label": "SI",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Inhibition of sucrase by HPLC",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65833",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "milnacipran targets SLC6A2",
"source_label": "milnacipran",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:65833",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "milnacipran targets SLC6A4",
"source_label": "milnacipran",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.29",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4197",
"relation": "IDG (Drug Target)",
"target": "5139",
"properties": {
"id": "milrinone targets PDE3A",
"source_label": "milrinone",
"target_label": "PDE3A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Inhibitory concentration required to inhibit human phosphodiesterase 3A expressed in Escherichia coli",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4197",
"relation": "IDG (Drug Target)",
"target": "5140",
"properties": {
"id": "milrinone targets PDE3B",
"source_label": "milrinone",
"target_label": "PDE3B",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Inhibitory concentration required to inhibit human phosphodiesterase 3B expressed in Escherichia coli",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4197",
"relation": "IDG (Drug Target)",
"target": "8654",
"properties": {
"id": "milrinone targets PDE5A",
"source_label": "milrinone",
"target_label": "PDE5A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "Inhibitory activity against cGMP-phosphodiesterase from porcine aorta",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4201",
"relation": "IDG (Drug Target)",
"target": "3758",
"properties": {
"id": "minoxidil targets KCNJ1",
"source_label": "minoxidil",
"target_label": "KCNJ1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.97",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3085219",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "mirtazapine targets ADRA2A",
"source_label": "mirtazapine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3085219",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "mirtazapine targets ADRA2B",
"source_label": "mirtazapine",
"target_label": "ADRA2B",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.65",
"act_comment": "Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3085219",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "mirtazapine targets ADRA2C",
"source_label": "mirtazapine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.74",
"act_comment": "Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3085219",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "mirtazapine targets HRH1",
"source_label": "mirtazapine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.796",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3085219",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "mirtazapine targets HTR2A",
"source_label": "mirtazapine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.16",
"act_comment": "Inhibition of [125I]R91150 binding to human 5-hydroxytryptamine 2A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3085219",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "mirtazapine targets HTR2C",
"source_label": "mirtazapine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.41",
"act_comment": "Inhibition of [3H]mesulergine binding to human 5-hydroxytryptamine 2C receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3085219",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "mirtazapine targets HTR7",
"source_label": "mirtazapine",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.58",
"act_comment": "Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5282381",
"relation": "IDG (Drug Target)",
"target": "5732",
"properties": {
"id": "misoprostol targets PTGER2",
"source_label": "misoprostol",
"target_label": "PTGER2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5282381",
"relation": "IDG (Drug Target)",
"target": "5733",
"properties": {
"id": "misoprostol targets PTGER3",
"source_label": "misoprostol",
"target_label": "PTGER3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5282381",
"relation": "IDG (Drug Target)",
"target": "5734",
"properties": {
"id": "misoprostol targets PTGER4",
"source_label": "misoprostol",
"target_label": "PTGER4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4211",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "mitotane targets HTR6",
"source_label": "mitotane",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.186",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4211",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "mitotane targets SLC6A2",
"source_label": "mitotane",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4211",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "mitotane targets SLC6A3",
"source_label": "mitotane",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4212",
"relation": "IDG (Drug Target)",
"target": "4363",
"properties": {
"id": "mitoxantrone targets ABCC1",
"source_label": "mitoxantrone",
"target_label": "ABCC1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.287",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4212",
"relation": "IDG (Drug Target)",
"target": "695",
"properties": {
"id": "mitoxantrone targets BTK",
"source_label": "mitoxantrone",
"target_label": "BTK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Inhibition of BTK (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4212",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "mitoxantrone targets CHRM1",
"source_label": "mitoxantrone",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.744",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4212",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "mitoxantrone targets CHRM2",
"source_label": "mitoxantrone",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.108",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4212",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "mitoxantrone targets CHRM4",
"source_label": "mitoxantrone",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.047",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4212",
"relation": "IDG (Drug Target)",
"target": "5292",
"properties": {
"id": "mitoxantrone targets PIM1",
"source_label": "mitoxantrone",
"target_label": "PIM1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.29",
"act_comment": "Inhibition of recombinant PIM1 (unknown origin) expressed in Escherichia coli BL21(DE3) after 1 hr by HTRF assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4212",
"relation": "IDG (Drug Target)",
"target": "55244",
"properties": {
"id": "mitoxantrone targets SLC47A1",
"source_label": "mitoxantrone",
"target_label": "SLC47A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Inhibition of human MATE1-mediated [14]-metformin uptake expressed in polarized MDCK2 cells after 5 mins by liquid scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4212",
"relation": "IDG (Drug Target)",
"target": "146802",
"properties": {
"id": "mitoxantrone targets SLC47A2",
"source_label": "mitoxantrone",
"target_label": "SLC47A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells up to 500 uM after 1.5 mins by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65906",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "mizolastine targets HRH1",
"source_label": "mizolastine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.84",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:65906",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "mizolastine targets KCNH2",
"source_label": "mizolastine",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.456",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4235",
"relation": "IDG (Drug Target)",
"target": "4128",
"properties": {
"id": "moclobemide targets MAOA",
"source_label": "moclobemide",
"target_label": "MAOA",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "Inhibition of human MAO-A expressed in BTI insect cells using p-tyramine as substrate after 60 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4236",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "modafinil targets DRD2",
"source_label": "modafinil",
"target_label": "DRD2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:91270",
"relation": "IDG (Drug Target)",
"target": "1636",
"properties": {
"id": "moexipril targets ACE",
"source_label": "moexipril",
"target_label": "ACE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.59",
"act_comment": "Inhibitory activity against angiotensin I converting enzyme (ACE)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4237",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "mofezolac targets PTGS1",
"source_label": "mofezolac",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.85",
"act_comment": "Inhibition of COX1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4237",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "mofezolac targets PTGS2",
"source_label": "mofezolac",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Inhibition of COX2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:23897",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "molindone targets ADRA2B",
"source_label": "molindone",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.254",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:23897",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "molindone targets ADRA2C",
"source_label": "molindone",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.763",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:23897",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "molindone targets DRD2",
"source_label": "molindone",
"target_label": "DRD2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.157",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:23897",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "molindone targets DRD3",
"source_label": "molindone",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:23897",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "molindone targets HTR2A",
"source_label": "molindone",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:23897",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "molindone targets HTR7",
"source_label": "molindone",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.58",
"act_comment": "Binding affinity towards human 5-hydroxytryptamine 7 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:23897",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "molindone targets SIGMAR1",
"source_label": "molindone",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.907",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:441336",
"relation": "IDG (Drug Target)",
"target": "5243",
"properties": {
"id": "mometasone furoate targets ABCB1",
"source_label": "mometasone furoate",
"target_label": "ABCB1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:441336",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "mometasone furoate targets NR3C1",
"source_label": "mometasone furoate",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.15",
"act_comment": "Inhibition of glucocorticoid receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:441336",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "mometasone furoate targets PGR",
"source_label": "mometasone furoate",
"target_label": "PGR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5281040",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "montelukast targets ADORA3",
"source_label": "montelukast",
"target_label": "ADORA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.611",
"act_comment": "DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5281040",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "montelukast targets ADRA2C",
"source_label": "montelukast",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.115",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5281040",
"relation": "IDG (Drug Target)",
"target": "10800",
"properties": {
"id": "montelukast targets CYSLTR1",
"source_label": "montelukast",
"target_label": "CYSLTR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "GRAC: human CysLT1 selective antagonist",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5281040",
"relation": "IDG (Drug Target)",
"target": "1432",
"properties": {
"id": "montelukast targets MAPK14",
"source_label": "montelukast",
"target_label": "MAPK14",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.068",
"act_comment": "DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4249",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "moperone targets DRD2",
"source_label": "moperone",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4249",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "moperone targets DRD3",
"source_label": "moperone",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.5",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4249",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "moperone targets DRD4",
"source_label": "moperone",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.134",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5288826",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "morphine targets OPRD1",
"source_label": "morphine",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5288826",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "morphine targets OPRK1",
"source_label": "morphine",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.97",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5288826",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "morphine targets OPRM1",
"source_label": "morphine",
"target_label": "OPRM1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.86",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4257",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "mosapramine targets DRD4",
"source_label": "mosapramine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.52",
"act_comment": "Agonist activity at dopamine D4 receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:119584",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "mosapride targets ADRA2B",
"source_label": "mosapride",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.06",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:119584",
"relation": "IDG (Drug Target)",
"target": "1544",
"properties": {
"id": "mosapride targets CYP1A2",
"source_label": "mosapride",
"target_label": "CYP1A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.398",
"act_comment": "DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:119584",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "mosapride targets CYP2C19",
"source_label": "mosapride",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:119584",
"relation": "IDG (Drug Target)",
"target": "1559",
"properties": {
"id": "mosapride targets CYP2C9",
"source_label": "mosapride",
"target_label": "CYP2C9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:119584",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "mosapride targets CYP3A4",
"source_label": "mosapride",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.155",
"act_comment": "DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:119584",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "mosapride targets HTR2B",
"source_label": "mosapride",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.725",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:119584",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "mosapride targets HTR2C",
"source_label": "mosapride",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.683",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:119584",
"relation": "IDG (Drug Target)",
"target": "3360",
"properties": {
"id": "mosapride targets HTR4",
"source_label": "mosapride",
"target_label": "HTR4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:119584",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "mosapride targets SIGMAR1",
"source_label": "mosapride",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.891",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4810",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "moxonidine targets ADRA2A",
"source_label": "moxonidine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "Binding affinity for human Alpha-2A adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4810",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "moxonidine targets HTR1A",
"source_label": "moxonidine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.397",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4810",
"relation": "IDG (Drug Target)",
"target": "11188",
"properties": {
"id": "moxonidine targets NISCH",
"source_label": "moxonidine",
"target_label": "NISCH",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.38",
"act_comment": "Displacement of [125I]PIC from human imidazoline receptor 1 in human platelets analyzed under norepinephrine mask of alpha 2AR",
"act_source": "CHEMBL"
}
},
{
"source": "CID:446596",
"relation": "IDG (Drug Target)",
"target": "3376",
"properties": {
"id": "mupirocin targets IARS1",
"source_label": "mupirocin",
"target_label": "IARS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "Compound was evaluated for inhibitory activity against Isoleucyl-tRNA synthetase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5281078",
"relation": "IDG (Drug Target)",
"target": "3614",
"properties": {
"id": "mycophenolate mofetil targets IMPDH1",
"source_label": "mycophenolate mofetil",
"target_label": "IMPDH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.481",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5281078",
"relation": "IDG (Drug Target)",
"target": "3615",
"properties": {
"id": "mycophenolate mofetil targets IMPDH2",
"source_label": "mycophenolate mofetil",
"target_label": "IMPDH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.155",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:446541",
"relation": "IDG (Drug Target)",
"target": "3614",
"properties": {
"id": "mycophenolic acid targets IMPDH1",
"source_label": "mycophenolic acid",
"target_label": "IMPDH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.48",
"act_comment": "Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I isoform); Range is 33-37 nM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:446541",
"relation": "IDG (Drug Target)",
"target": "3615",
"properties": {
"id": "mycophenolic acid targets IMPDH2",
"source_label": "mycophenolic acid",
"target_label": "IMPDH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II isoform); Range is 6-10 nM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:39860",
"relation": "IDG (Drug Target)",
"target": "1268",
"properties": {
"id": "nabilone targets CNR1",
"source_label": "nabilone",
"target_label": "CNR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "Displacement of [3H]-CP55940 from human CB1 receptor expressed in CHO cells by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:39860",
"relation": "IDG (Drug Target)",
"target": "1269",
"properties": {
"id": "nabilone targets CNR2",
"source_label": "nabilone",
"target_label": "CNR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "Displacement of [3H]-CP55940 from human CB2 receptor expressed in CHO cells by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4409",
"relation": "IDG (Drug Target)",
"target": "4128",
"properties": {
"id": "nabumetone targets MAOA",
"source_label": "nabumetone",
"target_label": "MAOA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.001",
"act_comment": "DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:39147",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "nadolol targets ADRB1",
"source_label": "nadolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:39147",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "nadolol targets ADRB2",
"source_label": "nadolol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:39147",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "nadolol targets ADRB3",
"source_label": "nadolol",
"target_label": "ADRB3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4413",
"relation": "IDG (Drug Target)",
"target": "715",
"properties": {
"id": "nafamostat targets C1R",
"source_label": "nafamostat",
"target_label": "C1R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Inhibition of C1r serine protease",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4413",
"relation": "IDG (Drug Target)",
"target": "716",
"properties": {
"id": "nafamostat targets C1S",
"source_label": "nafamostat",
"target_label": "C1S",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Compound was evaluated for inhibitory activity against C1s serine protease. ",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4413",
"relation": "IDG (Drug Target)",
"target": "2147",
"properties": {
"id": "nafamostat targets F2",
"source_label": "nafamostat",
"target_label": "F2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Compound was evaluated for inhibitory activity against Thrombin.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4413",
"relation": "IDG (Drug Target)",
"target": "3083",
"properties": {
"id": "nafamostat targets HGFAC",
"source_label": "nafamostat",
"target_label": "HGFAC",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4413",
"relation": "IDG (Drug Target)",
"target": "3249",
"properties": {
"id": "nafamostat targets HPN",
"source_label": "nafamostat",
"target_label": "HPN",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.28",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4413",
"relation": "IDG (Drug Target)",
"target": "3816",
"properties": {
"id": "nafamostat targets KLK1",
"source_label": "nafamostat",
"target_label": "KLK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Compound was evaluated for inhibitory activity against Kallikrein.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4413",
"relation": "IDG (Drug Target)",
"target": "5340",
"properties": {
"id": "nafamostat targets PLG",
"source_label": "nafamostat",
"target_label": "PLG",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Compound was evaluated for inhibitory activity against plasmin.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4413",
"relation": "IDG (Drug Target)",
"target": "5644",
"properties": {
"id": "nafamostat targets PRSS1",
"source_label": "nafamostat",
"target_label": "PRSS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "In vitro for inhibition of purified bovine trypsin.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4413",
"relation": "IDG (Drug Target)",
"target": "6768",
"properties": {
"id": "nafamostat targets ST14",
"source_label": "nafamostat",
"target_label": "ST14",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.7",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4413",
"relation": "IDG (Drug Target)",
"target": "7113",
"properties": {
"id": "nafamostat targets TMPRSS2",
"source_label": "nafamostat",
"target_label": "TMPRSS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Inhibition of TMPRSS2-dependent MERS-S-mediated membrane fusion in an in vitro reporter assay.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4413",
"relation": "IDG (Drug Target)",
"target": "7177",
"properties": {
"id": "nafamostat targets TPSAB1",
"source_label": "nafamostat",
"target_label": "TPSAB1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:25077405",
"relation": "IDG (Drug Target)",
"target": "2798",
"properties": {
"id": "nafarelin targets GNRHR",
"source_label": "nafarelin",
"target_label": "GNRHR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.699",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4417",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "naftidrofuryl targets HTR2A",
"source_label": "naftidrofuryl",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "Displacement of [3H]ketanserin from 5HT2A receptor expressed in HEK293 cells by liquid scintillation spectrophotometry",
"act_source": "CHEMBL"
}
},
{
"source": "CID:47641",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "naftifine targets SIGMAR1",
"source_label": "naftifine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.06",
"act_comment": "Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4418",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "naftopidil targets ADRA1A",
"source_label": "naftopidil",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.432",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:4418",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "naftopidil targets ADRA1B",
"source_label": "naftopidil",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.699",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:4418",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "naftopidil targets ADRA1D",
"source_label": "naftopidil",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.921",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5311304",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "nalbuphine targets OPRD1",
"source_label": "nalbuphine",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5311304",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "nalbuphine targets OPRK1",
"source_label": "nalbuphine",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5311304",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "nalbuphine targets OPRM1",
"source_label": "nalbuphine",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284594",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "nalmefene targets OPRD1",
"source_label": "nalmefene",
"target_label": "OPRD1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.04",
"act_comment": "Activity at human delta opioid receptor by [35S]GTPgammaS binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284594",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "nalmefene targets OPRK1",
"source_label": "nalmefene",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.92",
"act_comment": "Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284594",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "nalmefene targets OPRM1",
"source_label": "nalmefene",
"target_label": "OPRM1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.53",
"act_comment": "Activity at human mu opioid receptor by [35S]GTPgammaS binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284595",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "nalorphine targets OPRD1",
"source_label": "nalorphine",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284595",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "nalorphine targets OPRK1",
"source_label": "nalorphine",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.42",
"act_comment": "Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284595",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "nalorphine targets OPRM1",
"source_label": "nalorphine",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.72",
"act_comment": "Displacement of [3H]DAMGO form human mu opioid receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284595",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "nalorphine targets SIGMAR1",
"source_label": "nalorphine",
"target_label": "SIGMAR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.32",
"act_comment": "Inhibition of specific binding of [3H]NANM of sigma receptor in Guinea pig brain membranes",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5702090",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "naloxone targets ADORA3",
"source_label": "naloxone",
"target_label": "ADORA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5702090",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "naloxone targets OPRD1",
"source_label": "naloxone",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.27",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5702090",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "naloxone targets OPRK1",
"source_label": "naloxone",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5702090",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "naloxone targets OPRM1",
"source_label": "naloxone",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.81",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9904",
"relation": "IDG (Drug Target)",
"target": "866",
"properties": {
"id": "nandrolone targets SERPINA6",
"source_label": "nandrolone",
"target_label": "SERPINA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9904",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "nandrolone targets SHBG",
"source_label": "nandrolone",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9677",
"relation": "IDG (Drug Target)",
"target": "866",
"properties": {
"id": "nandrolone decanoate targets SERPINA6",
"source_label": "nandrolone decanoate",
"target_label": "SERPINA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Binding affinity to human CBG receptor (corticosteroid-binding globulins)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9677",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "nandrolone decanoate targets SHBG",
"source_label": "nandrolone decanoate",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:229455",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "nandrolone phenpropionate targets AR",
"source_label": "nandrolone phenpropionate",
"target_label": "AR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:229455",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "nandrolone phenpropionate targets ESR1",
"source_label": "nandrolone phenpropionate",
"target_label": "ESR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:156391",
"relation": "IDG (Drug Target)",
"target": "8644",
"properties": {
"id": "naproxen targets AKR1C3",
"source_label": "naproxen",
"target_label": "AKR1C3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.32",
"act_comment": "Inhibition of recombinant human AKR1C3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4440",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "naratriptan targets HTR1A",
"source_label": "naratriptan",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.35",
"act_comment": "In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4440",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "naratriptan targets HTR1B",
"source_label": "naratriptan",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.48",
"act_comment": "In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4440",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "naratriptan targets HTR1D",
"source_label": "naratriptan",
"target_label": "HTR1D",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.796",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4440",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "naratriptan targets HTR1E",
"source_label": "naratriptan",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4440",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "naratriptan targets HTR1F",
"source_label": "naratriptan",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:71301",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "nebivolol targets ADRB1",
"source_label": "nebivolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71301",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "nebivolol targets ADRB2",
"source_label": "nebivolol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71301",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "nebivolol targets HTR1A",
"source_label": "nebivolol",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:50294",
"relation": "IDG (Drug Target)",
"target": "2859",
"properties": {
"id": "nedocromil targets GPR35",
"source_label": "nedocromil",
"target_label": "GPR35",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.013",
"act_comment": "GPR35a\u00e2\u20ac\u201cbeta-arrestin-2 interaction assays performed using a CHO\u00e2\u20ac\u201cK1 cell line stably expressing human GPR35 and beta-arrestin-2",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:4449",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "nefazodone targets ADRA1A",
"source_label": "nefazodone",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.789",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4449",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "nefazodone targets ADRA2B",
"source_label": "nefazodone",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.635",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4449",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "nefazodone targets CYP3A4",
"source_label": "nefazodone",
"target_label": "CYP3A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4449",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "nefazodone targets DRD2",
"source_label": "nefazodone",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.745",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4449",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "nefazodone targets HRH1",
"source_label": "nefazodone",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.432",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4449",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "nefazodone targets HTR1A",
"source_label": "nefazodone",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.097",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4449",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "nefazodone targets HTR2A",
"source_label": "nefazodone",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4449",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "nefazodone targets SLC6A2",
"source_label": "nefazodone",
"target_label": "SLC6A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.444",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4449",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "nefazodone targets SLC6A3",
"source_label": "nefazodone",
"target_label": "SLC6A3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.444",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4449",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "nefazodone targets SLC6A4",
"source_label": "nefazodone",
"target_label": "SLC6A4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.699",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4452",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "nemonapride targets DRD3",
"source_label": "nemonapride",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4452",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "nemonapride targets DRD4",
"source_label": "nemonapride",
"target_label": "DRD4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.68",
"act_comment": "Binding Affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:8378",
"relation": "IDG (Drug Target)",
"target": "7442",
"properties": {
"id": "framycetin targets TRPV1",
"source_label": "framycetin",
"target_label": "TRPV1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Inhibition of TRPV1-mediated membrane currents in human DRG neurons",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4456",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "neostigmine targets ACHE",
"source_label": "neostigmine",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.59",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4456",
"relation": "IDG (Drug Target)",
"target": "590",
"properties": {
"id": "neostigmine targets BCHE",
"source_label": "neostigmine",
"target_label": "BCHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.22",
"act_comment": "Inhibition of human plasma BChE pretreated for 30 mins by Ellman technique",
"act_source": "CHEMBL"
}
},
{
"source": "CID:151075",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "nepafenac targets PTGS1",
"source_label": "nepafenac",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:151075",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "nepafenac targets PTGS2",
"source_label": "nepafenac",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3047788",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "nepinalone targets SIGMAR1",
"source_label": "nepinalone",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.523",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:73707445",
"relation": "IDG (Drug Target)",
"target": "1559",
"properties": {
"id": "nicardipine targets CYP2C9",
"source_label": "nicardipine",
"target_label": "CYP2C9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.553",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:73707445",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "nicardipine targets CYP3A4",
"source_label": "nicardipine",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.377",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4477",
"relation": "IDG (Drug Target)",
"target": "1559",
"properties": {
"id": "niclosamide targets CYP2C9",
"source_label": "niclosamide",
"target_label": "CYP2C9",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.046",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4477",
"relation": "IDG (Drug Target)",
"target": "6774",
"properties": {
"id": "niclosamide targets STAT3",
"source_label": "niclosamide",
"target_label": "STAT3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Inhibition of STAT3 in human HeLa cells after 24 hrs by luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:47528",
"relation": "IDG (Drug Target)",
"target": "4881",
"properties": {
"id": "nicorandil targets NPR1",
"source_label": "nicorandil",
"target_label": "NPR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:89594",
"relation": "IDG (Drug Target)",
"target": "1136",
"properties": {
"id": "nicotine targets CHRNA3",
"source_label": "nicotine",
"target_label": "CHRNA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.35",
"act_comment": "Inhibition of [3H]nicotine binding to alpha3 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cells co-expressing beta2beta4alpha5 Nicotinic acetylcholine receptor subunits",
"act_source": "CHEMBL"
}
},
{
"source": "CID:89594",
"relation": "IDG (Drug Target)",
"target": "3752",
"properties": {
"id": "nicotine targets KCND3",
"source_label": "nicotine",
"target_label": "KCND3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4485",
"relation": "IDG (Drug Target)",
"target": "775",
"properties": {
"id": "nifedipine targets CACNA1C",
"source_label": "nifedipine",
"target_label": "CACNA1C",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "Displacement of [3H]nitrendipine from dihydropyridine receptor of guinea pig myocardial membranes",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4485",
"relation": "IDG (Drug Target)",
"target": "776",
"properties": {
"id": "nifedipine targets CACNA1D",
"source_label": "nifedipine",
"target_label": "CACNA1D",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Recombinant Cav1.3 calcium channel complexes expressed in tsA-cells",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4485",
"relation": "IDG (Drug Target)",
"target": "778",
"properties": {
"id": "nifedipine targets CACNA1F",
"source_label": "nifedipine",
"target_label": "CACNA1F",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4485",
"relation": "IDG (Drug Target)",
"target": "779",
"properties": {
"id": "nifedipine targets CACNA1S",
"source_label": "nifedipine",
"target_label": "CACNA1S",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4485",
"relation": "IDG (Drug Target)",
"target": "729230",
"properties": {
"id": "nifedipine targets CCR2",
"source_label": "nifedipine",
"target_label": "CCR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.072",
"act_comment": "DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4485",
"relation": "IDG (Drug Target)",
"target": "1544",
"properties": {
"id": "nifedipine targets CYP1A2",
"source_label": "nifedipine",
"target_label": "CYP1A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.523",
"act_comment": "DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4485",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "nifedipine targets HTR2A",
"source_label": "nifedipine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.495",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4486",
"relation": "IDG (Drug Target)",
"target": "55244",
"properties": {
"id": "nifekalant targets SLC47A1",
"source_label": "nifekalant",
"target_label": "SLC47A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Inhibition of human MATE1-mediated [14]-metformin uptake expressed in polarized MDCK2 cells after 5 mins by liquid scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4488",
"relation": "IDG (Drug Target)",
"target": "343450",
"properties": {
"id": "niflumic acid targets KCNT2",
"source_label": "niflumic acid",
"target_label": "KCNT2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.68",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4488",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "niflumic acid targets PTGS2",
"source_label": "niflumic acid",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.037",
"act_comment": "DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4488",
"relation": "IDG (Drug Target)",
"target": "7276",
"properties": {
"id": "niflumic acid targets TTR",
"source_label": "niflumic acid",
"target_label": "TTR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "nilotinib targets ABL1",
"source_label": "nilotinib",
"target_label": "ABL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.44",
"act_comment": "Binding affinity to human ABL1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "27",
"properties": {
"id": "nilotinib targets ABL2",
"source_label": "nilotinib",
"target_label": "ABL2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.59",
"act_comment": "Binding constant for ABL2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "640",
"properties": {
"id": "nilotinib targets BLK",
"source_label": "nilotinib",
"target_label": "BLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Binding constant for BLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "673",
"properties": {
"id": "nilotinib targets BRAF",
"source_label": "nilotinib",
"target_label": "BRAF",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Binding constant for BRAF(V600E) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "nilotinib targets CA1",
"source_label": "nilotinib",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.53",
"act_comment": "Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "nilotinib targets CA12",
"source_label": "nilotinib",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "23632",
"properties": {
"id": "nilotinib targets CA14",
"source_label": "nilotinib",
"target_label": "CA14",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.65",
"act_comment": "Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "nilotinib targets CA2",
"source_label": "nilotinib",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.39",
"act_comment": "Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "761",
"properties": {
"id": "nilotinib targets CA3",
"source_label": "nilotinib",
"target_label": "CA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Inhibition of human carbonic anhydrase 3 by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "762",
"properties": {
"id": "nilotinib targets CA4",
"source_label": "nilotinib",
"target_label": "CA4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "nilotinib targets CA6",
"source_label": "nilotinib",
"target_label": "CA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.34",
"act_comment": "Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "nilotinib targets CA7",
"source_label": "nilotinib",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "nilotinib targets CA9",
"source_label": "nilotinib",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.38",
"act_comment": "Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "9578",
"properties": {
"id": "nilotinib targets CDC42BPB",
"source_label": "nilotinib",
"target_label": "CDC42BPB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "Binding constant for MRCKB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "1436",
"properties": {
"id": "nilotinib targets CSF1R",
"source_label": "nilotinib",
"target_label": "CSF1R",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.35",
"act_comment": "Binding constant for CSF1R kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "780",
"properties": {
"id": "nilotinib targets DDR1",
"source_label": "nilotinib",
"target_label": "DDR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.96",
"act_comment": "Binding constant for DDR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "4921",
"properties": {
"id": "nilotinib targets DDR2",
"source_label": "nilotinib",
"target_label": "DDR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "Binding affinity to wild type DDR2 (unknown origin) by FLiK assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "2041",
"properties": {
"id": "nilotinib targets EPHA1",
"source_label": "nilotinib",
"target_label": "EPHA1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.23",
"act_comment": "Binding constant for EPHA1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "1969",
"properties": {
"id": "nilotinib targets EPHA2",
"source_label": "nilotinib",
"target_label": "EPHA2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Binding constant for EPHA2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "2042",
"properties": {
"id": "nilotinib targets EPHA3",
"source_label": "nilotinib",
"target_label": "EPHA3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Binding constant for EPHA3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "2043",
"properties": {
"id": "nilotinib targets EPHA4",
"source_label": "nilotinib",
"target_label": "EPHA4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Binding constant for EPHA4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "285220",
"properties": {
"id": "nilotinib targets EPHA6",
"source_label": "nilotinib",
"target_label": "EPHA6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Binding constant for EPHA6 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "2046",
"properties": {
"id": "nilotinib targets EPHA8",
"source_label": "nilotinib",
"target_label": "EPHA8",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.43",
"act_comment": "Binding constant for EPHA8 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "2048",
"properties": {
"id": "nilotinib targets EPHB2",
"source_label": "nilotinib",
"target_label": "EPHB2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Binding constant for EPHB2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "2049",
"properties": {
"id": "nilotinib targets EPHB3",
"source_label": "nilotinib",
"target_label": "EPHB3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for EPHB3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "2050",
"properties": {
"id": "nilotinib targets EPHB4",
"source_label": "nilotinib",
"target_label": "EPHB4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Binding constant for EPHB4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "2051",
"properties": {
"id": "nilotinib targets EPHB6",
"source_label": "nilotinib",
"target_label": "EPHB6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Binding constant for EPHB6 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "2268",
"properties": {
"id": "nilotinib targets FGR",
"source_label": "nilotinib",
"target_label": "FGR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.49",
"act_comment": "Binding constant for FGR kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "2444",
"properties": {
"id": "nilotinib targets FRK",
"source_label": "nilotinib",
"target_label": "FRK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.07",
"act_comment": "Binding constant for FRK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "3055",
"properties": {
"id": "nilotinib targets HCK",
"source_label": "nilotinib",
"target_label": "HCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "Binding constant for HCK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "3611",
"properties": {
"id": "nilotinib targets ILK",
"source_label": "nilotinib",
"target_label": "ILK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "nilotinib targets KCNH2",
"source_label": "nilotinib",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Inhibition of human ERG incubated for 4 hrs by competitive fluorescence tracer binding based assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "nilotinib targets KIT",
"source_label": "nilotinib",
"target_label": "KIT",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "Binding affinity to human c-Kit",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "nilotinib targets LCK",
"source_label": "nilotinib",
"target_label": "LCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.33",
"act_comment": "Binding constant for LCK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "4067",
"properties": {
"id": "nilotinib targets LYN",
"source_label": "nilotinib",
"target_label": "LYN",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Binding constant for LYN kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "5607",
"properties": {
"id": "nilotinib targets MAP2K5",
"source_label": "nilotinib",
"target_label": "MAP2K5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Binding constant for MEK5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "11184",
"properties": {
"id": "nilotinib targets MAP4K1",
"source_label": "nilotinib",
"target_label": "MAP4K1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Binding constant for HPK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "5600",
"properties": {
"id": "nilotinib targets MAPK11",
"source_label": "nilotinib",
"target_label": "MAPK11",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.44",
"act_comment": "Binding constant for p38-beta kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "1432",
"properties": {
"id": "nilotinib targets MAPK14",
"source_label": "nilotinib",
"target_label": "MAPK14",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.34",
"act_comment": "Binding constant for p38-alpha kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "5599",
"properties": {
"id": "nilotinib targets MAPK8",
"source_label": "nilotinib",
"target_label": "MAPK8",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Binding constant for JNK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "4835",
"properties": {
"id": "nilotinib targets NQO2",
"source_label": "nilotinib",
"target_label": "NQO2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Inhibition of full length human His6/GST-tagged NQO2 expressed in Escherichia coli Tuner(DE3)pLysS using menadione as substrate and CCHP as co-substrate preincubated with enzyme followed by substrate addition by MTT dye based continuous spectrophotometric assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "4915",
"properties": {
"id": "nilotinib targets NTRK2",
"source_label": "nilotinib",
"target_label": "NTRK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.31",
"act_comment": "Binding constant for TRKB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "4916",
"properties": {
"id": "nilotinib targets NTRK3",
"source_label": "nilotinib",
"target_label": "NTRK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Binding constant for TRKC kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "5156",
"properties": {
"id": "nilotinib targets PDGFRA",
"source_label": "nilotinib",
"target_label": "PDGFRA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.13",
"act_comment": "Binding affinity to human PDGFRalpha",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "nilotinib targets PDGFRB",
"source_label": "nilotinib",
"target_label": "PDGFRB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "Binding affinity to human PDGFRbeata",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "5261",
"properties": {
"id": "nilotinib targets PHKG2",
"source_label": "nilotinib",
"target_label": "PHKG2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "nilotinib targets RET",
"source_label": "nilotinib",
"target_label": "RET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.06",
"act_comment": "Binding constant for RET kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "7010",
"properties": {
"id": "nilotinib targets TEK",
"source_label": "nilotinib",
"target_label": "TEK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for TIE2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "7075",
"properties": {
"id": "nilotinib targets TIE1",
"source_label": "nilotinib",
"target_label": "TIE1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for TIE1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "51086",
"properties": {
"id": "nilotinib targets TNNI3K",
"source_label": "nilotinib",
"target_label": "TNNI3K",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Binding constant for TNNI3K kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644241",
"relation": "IDG (Drug Target)",
"target": "51776",
"properties": {
"id": "nilotinib targets MAP3K20",
"source_label": "nilotinib",
"target_label": "MAP3K20",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Binding constant for ZAK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4493",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "nilutamide targets AR",
"source_label": "nilutamide",
"target_label": "AR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "Inhibition of 1.0 nM [3H]mibolerone binding to human androgen receptor of PC3/AR cell lysate",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4497",
"relation": "IDG (Drug Target)",
"target": "1559",
"properties": {
"id": "nimodipine targets CYP2C9",
"source_label": "nimodipine",
"target_label": "CYP2C9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4497",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "nimodipine targets CYP3A4",
"source_label": "nimodipine",
"target_label": "CYP3A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4497",
"relation": "IDG (Drug Target)",
"target": "8856",
"properties": {
"id": "nimodipine targets NR1I2",
"source_label": "nimodipine",
"target_label": "NR1I2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "Agonist activity at PXR (unknown origin) expressed in human HepG2 cells assessed as induction of CYP3A4 transactivation after 16 hrs by luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4497",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "nimodipine targets NR3C2",
"source_label": "nimodipine",
"target_label": "NR3C2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4497",
"relation": "IDG (Drug Target)",
"target": "9154",
"properties": {
"id": "nimodipine targets SLC28A1",
"source_label": "nimodipine",
"target_label": "SLC28A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.364",
"act_comment": "DRUGMATRIX: Sodium/nucleoside co-transporter radioligand binding (ligand: nitrobenzylthioinosine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4499",
"relation": "IDG (Drug Target)",
"target": "775",
"properties": {
"id": "nisoldipine targets CACNA1C",
"source_label": "nisoldipine",
"target_label": "CACNA1C",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4499",
"relation": "IDG (Drug Target)",
"target": "1544",
"properties": {
"id": "nisoldipine targets CYP1A2",
"source_label": "nisoldipine",
"target_label": "CYP1A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:115355",
"relation": "IDG (Drug Target)",
"target": "3242",
"properties": {
"id": "nitisinone targets HPD",
"source_label": "nitisinone",
"target_label": "HPD",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.398",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4507",
"relation": "IDG (Drug Target)",
"target": "775",
"properties": {
"id": "nitrendipine targets CACNA1C",
"source_label": "nitrendipine",
"target_label": "CACNA1C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.6",
"act_comment": "Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesicles",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4507",
"relation": "IDG (Drug Target)",
"target": "776",
"properties": {
"id": "nitrendipine targets CACNA1D",
"source_label": "nitrendipine",
"target_label": "CACNA1D",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "Recombinant Cav1.3 calcium channel complexes expressed in tsA-cells",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4507",
"relation": "IDG (Drug Target)",
"target": "1559",
"properties": {
"id": "nitrendipine targets CYP2C9",
"source_label": "nitrendipine",
"target_label": "CYP2C9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.523",
"act_comment": "DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4507",
"relation": "IDG (Drug Target)",
"target": "3783",
"properties": {
"id": "nitrendipine targets KCNN4",
"source_label": "nitrendipine",
"target_label": "KCNN4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6604200",
"relation": "IDG (Drug Target)",
"target": "55847",
"properties": {
"id": "nitrofurantoin targets CISD1",
"source_label": "nitrofurantoin",
"target_label": "CISD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by Cheng-Prusoff analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:19910",
"relation": "IDG (Drug Target)",
"target": "23476",
"properties": {
"id": "nitroxoline targets BRD4",
"source_label": "nitroxoline",
"target_label": "BRD4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Inhibition of BRD4 in human MV4-11 cells using biotin labelled N-C:SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVGG-K as substrate preincubated for 15 mins followed by substrate addition measured after 5 mins by alpha screen assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:19910",
"relation": "IDG (Drug Target)",
"target": "10988",
"properties": {
"id": "nitroxoline targets METAP2",
"source_label": "nitroxoline",
"target_label": "METAP2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.26",
"act_comment": "Inhibition of human methionine aminopeptidase 2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:19910",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "nitroxoline targets PTGS2",
"source_label": "nitroxoline",
"target_label": "PTGS2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3033637",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "nizatidine targets HRH2",
"source_label": "nizatidine",
"target_label": "HRH2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4528",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "nomifensine targets SLC6A2",
"source_label": "nomifensine",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.67",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4528",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "nomifensine targets SLC6A3",
"source_label": "nomifensine",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.31",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:439260",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "norepinephrine targets ADRA1D",
"source_label": "norepinephrine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:439260",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "norepinephrine targets ADRA2A",
"source_label": "norepinephrine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.18",
"act_comment": "Binding affinity for human Alpha-2A adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:439260",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "norepinephrine targets ADRA2C",
"source_label": "norepinephrine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "Binding affinity for human Alpha-2C adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:439260",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "norepinephrine targets ADRB1",
"source_label": "norepinephrine",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6230",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "norethisterone targets AR",
"source_label": "norethisterone",
"target_label": "AR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.12",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6230",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "norethisterone targets ESR1",
"source_label": "norethisterone",
"target_label": "ESR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.636",
"act_comment": "DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6230",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "norethisterone targets NR3C1",
"source_label": "norethisterone",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.706",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6230",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "norethisterone targets PGR",
"source_label": "norethisterone",
"target_label": "PGR",
"act_type": "ED50",
"act_relation": "=",
"act_value": "11.26",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6230",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "norethisterone targets SHBG",
"source_label": "norethisterone",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.97",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5832",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "norethindrone acetate targets AR",
"source_label": "norethindrone acetate",
"target_label": "AR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.12",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5832",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "norethindrone acetate targets CYP2C19",
"source_label": "norethindrone acetate",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.097",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5832",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "norethindrone acetate targets ESR1",
"source_label": "norethindrone acetate",
"target_label": "ESR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5832",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "norethindrone acetate targets NR3C1",
"source_label": "norethindrone acetate",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.533",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5832",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "norethindrone acetate targets PGR",
"source_label": "norethindrone acetate",
"target_label": "PGR",
"act_type": "ED50",
"act_relation": "=",
"act_value": "11.26",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5832",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "norethindrone acetate targets SHBG",
"source_label": "norethindrone acetate",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.97",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4539",
"relation": "IDG (Drug Target)",
"target": "2554",
"properties": {
"id": "norfloxacin targets GABRA1",
"source_label": "norfloxacin",
"target_label": "GABRA1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4539",
"relation": "IDG (Drug Target)",
"target": "2555",
"properties": {
"id": "norfloxacin targets GABRA2",
"source_label": "norfloxacin",
"target_label": "GABRA2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4539",
"relation": "IDG (Drug Target)",
"target": "2556",
"properties": {
"id": "norfloxacin targets GABRA3",
"source_label": "norfloxacin",
"target_label": "GABRA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4539",
"relation": "IDG (Drug Target)",
"target": "2557",
"properties": {
"id": "norfloxacin targets GABRA4",
"source_label": "norfloxacin",
"target_label": "GABRA4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4539",
"relation": "IDG (Drug Target)",
"target": "2558",
"properties": {
"id": "norfloxacin targets GABRA5",
"source_label": "norfloxacin",
"target_label": "GABRA5",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4539",
"relation": "IDG (Drug Target)",
"target": "2559",
"properties": {
"id": "norfloxacin targets GABRA6",
"source_label": "norfloxacin",
"target_label": "GABRA6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4539",
"relation": "IDG (Drug Target)",
"target": "7155",
"properties": {
"id": "norfloxacin targets TOP2B",
"source_label": "norfloxacin",
"target_label": "TOP2B",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "nortriptyline targets ADRA1A",
"source_label": "nortriptyline",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.26",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "nortriptyline targets ADRA1D",
"source_label": "nortriptyline",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.91",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "nortriptyline targets ADRA2A",
"source_label": "nortriptyline",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.561",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "nortriptyline targets ADRA2B",
"source_label": "nortriptyline",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "nortriptyline targets ADRA2C",
"source_label": "nortriptyline",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.523",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "316",
"properties": {
"id": "nortriptyline targets AOX1",
"source_label": "nortriptyline",
"target_label": "AOX1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.071",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "nortriptyline targets CHRM1",
"source_label": "nortriptyline",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.398",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "nortriptyline targets CHRM2",
"source_label": "nortriptyline",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.959",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "nortriptyline targets CHRM3",
"source_label": "nortriptyline",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.301",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "nortriptyline targets CHRM4",
"source_label": "nortriptyline",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.076",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "nortriptyline targets CHRM5",
"source_label": "nortriptyline",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.013",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "nortriptyline targets CYP2D6",
"source_label": "nortriptyline",
"target_label": "CYP2D6",
"act_type": "Km",
"act_relation": "=",
"act_value": "6.225",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "nortriptyline targets DRD1",
"source_label": "nortriptyline",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "nortriptyline targets DRD3",
"source_label": "nortriptyline",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.215",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "nortriptyline targets HRH1",
"source_label": "nortriptyline",
"target_label": "HRH1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.033",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "nortriptyline targets HTR1A",
"source_label": "nortriptyline",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.509",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "nortriptyline targets HTR2A",
"source_label": "nortriptyline",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.356",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "nortriptyline targets HTR2B",
"source_label": "nortriptyline",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.066",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "nortriptyline targets HTR2C",
"source_label": "nortriptyline",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "nortriptyline targets HTR6",
"source_label": "nortriptyline",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.67",
"act_comment": "Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1.5 hrs by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "nortriptyline targets SLC6A2",
"source_label": "nortriptyline",
"target_label": "SLC6A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.36",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4543",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "nortriptyline targets SLC6A4",
"source_label": "nortriptyline",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.34",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:19728",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "noscapine targets CYP2C19",
"source_label": "noscapine",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.398",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:122173801",
"relation": "IDG (Drug Target)",
"target": "6751",
"properties": {
"id": "octreotide targets SSTR1",
"source_label": "octreotide",
"target_label": "SSTR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.65",
"act_comment": "Displacement of [125I]-somatostatin from human sst1 receptor after 2 hrs by beta scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:122173801",
"relation": "IDG (Drug Target)",
"target": "6752",
"properties": {
"id": "octreotide targets SSTR2",
"source_label": "octreotide",
"target_label": "SSTR2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "10.699",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:122173801",
"relation": "IDG (Drug Target)",
"target": "6753",
"properties": {
"id": "octreotide targets SSTR3",
"source_label": "octreotide",
"target_label": "SSTR3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:122173801",
"relation": "IDG (Drug Target)",
"target": "6754",
"properties": {
"id": "octreotide targets SSTR4",
"source_label": "octreotide",
"target_label": "SSTR4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Displacement of [125I]-somatostatin from human sst4 receptor after 2 hrs by beta scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:122173801",
"relation": "IDG (Drug Target)",
"target": "6755",
"properties": {
"id": "octreotide targets SSTR5",
"source_label": "octreotide",
"target_label": "SSTR5",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.523",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "olanzapine targets ADRA1A",
"source_label": "olanzapine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.721",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "olanzapine targets ADRA1B",
"source_label": "olanzapine",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.582",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "olanzapine targets ADRA1D",
"source_label": "olanzapine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.585",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "olanzapine targets ADRA2A",
"source_label": "olanzapine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.492",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "olanzapine targets ADRA2B",
"source_label": "olanzapine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.086",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "olanzapine targets ADRA2C",
"source_label": "olanzapine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.538",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "olanzapine targets CHRM1",
"source_label": "olanzapine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.506",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "olanzapine targets CHRM2",
"source_label": "olanzapine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.102",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "olanzapine targets CHRM3",
"source_label": "olanzapine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.136",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "olanzapine targets CHRM4",
"source_label": "olanzapine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.682",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "olanzapine targets CHRM5",
"source_label": "olanzapine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.046",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "olanzapine targets DRD1",
"source_label": "olanzapine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.398",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "olanzapine targets DRD2",
"source_label": "olanzapine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.523",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "olanzapine targets DRD3",
"source_label": "olanzapine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.097",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "olanzapine targets DRD4",
"source_label": "olanzapine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.796",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "olanzapine targets DRD5",
"source_label": "olanzapine",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.046",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "2671",
"properties": {
"id": "olanzapine targets GFER",
"source_label": "olanzapine",
"target_label": "GFER",
"act_type": "AC50",
"act_relation": "=",
"act_value": "6.43",
"act_comment": "PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787]",
"act_source": "CHEMBL"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "3005",
"properties": {
"id": "olanzapine targets H1-0",
"source_label": "olanzapine",
"target_label": "H1-0",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, \u00ce\u00b1A1, 5-HT2C and H1 Receptors.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "olanzapine targets HRH1",
"source_label": "olanzapine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.155",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "olanzapine targets HRH2",
"source_label": "olanzapine",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.356",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "olanzapine targets HTR1B",
"source_label": "olanzapine",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.233",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "olanzapine targets HTR1D",
"source_label": "olanzapine",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.121",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "olanzapine targets HTR1F",
"source_label": "olanzapine",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.509",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "olanzapine targets HTR2A",
"source_label": "olanzapine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.319",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "olanzapine targets HTR2B",
"source_label": "olanzapine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.921",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "olanzapine targets HTR2C",
"source_label": "olanzapine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.959",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "olanzapine targets HTR3A",
"source_label": "olanzapine",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.695",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "olanzapine targets HTR6",
"source_label": "olanzapine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.097",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "olanzapine targets HTR7",
"source_label": "olanzapine",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.979",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "olanzapine targets KCNH2",
"source_label": "olanzapine",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:135398745",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "olanzapine targets SLC6A4",
"source_label": "olanzapine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:130881",
"relation": "IDG (Drug Target)",
"target": "185",
"properties": {
"id": "olmesartan medoxomil targets AGTR1",
"source_label": "olmesartan medoxomil",
"target_label": "AGTR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5281071",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "olopatadine targets HRH1",
"source_label": "olopatadine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.284",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:656629",
"relation": "IDG (Drug Target)",
"target": "1636",
"properties": {
"id": "omapatrilat targets ACE",
"source_label": "omapatrilat",
"target_label": "ACE",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "Inhibition of human somatic ACE C-terminal domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:656629",
"relation": "IDG (Drug Target)",
"target": "351",
"properties": {
"id": "omapatrilat targets APP",
"source_label": "omapatrilat",
"target_label": "APP",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Inhibition of APP (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:656629",
"relation": "IDG (Drug Target)",
"target": "4311",
"properties": {
"id": "omapatrilat targets MME",
"source_label": "omapatrilat",
"target_label": "MME",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "Inhibition of human somatic NEP",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4595",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "ondansetron targets HTR2B",
"source_label": "ondansetron",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.341",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4595",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "ondansetron targets HTR3A",
"source_label": "ondansetron",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4595",
"relation": "IDG (Drug Target)",
"target": "9177",
"properties": {
"id": "ondansetron targets HTR3B",
"source_label": "ondansetron",
"target_label": "HTR3B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "GRAC: human 5-HT3B selective antagonist",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4595",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "ondansetron targets KCNH2",
"source_label": "ondansetron",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.091",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4595",
"relation": "IDG (Drug Target)",
"target": "55244",
"properties": {
"id": "ondansetron targets SLC47A1",
"source_label": "ondansetron",
"target_label": "SLC47A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "Inhibition of human MATE1-mediated [14]-metformin uptake expressed in HEK293 cells after 1.5 mins by scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4595",
"relation": "IDG (Drug Target)",
"target": "146802",
"properties": {
"id": "ondansetron targets SLC47A2",
"source_label": "ondansetron",
"target_label": "SLC47A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells up to 500 uM after 1.5 mins by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9417",
"relation": "IDG (Drug Target)",
"target": "10682",
"properties": {
"id": "opipramol targets EBP",
"source_label": "opipramol",
"target_label": "EBP",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Affinity for human EMP expressed in ERG2 deficient strain of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9417",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "opipramol targets SIGMAR1",
"source_label": "opipramol",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3034010",
"relation": "IDG (Drug Target)",
"target": "26090",
"properties": {
"id": "orlistat targets ABHD12",
"source_label": "orlistat",
"target_label": "ABHD12",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "Inhibition of recombinant ABHD12 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3034010",
"relation": "IDG (Drug Target)",
"target": "7920",
"properties": {
"id": "orlistat targets ABHD16A",
"source_label": "orlistat",
"target_label": "ABHD16A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "Inhibition of recombinant BAT5 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3034010",
"relation": "IDG (Drug Target)",
"target": "57406",
"properties": {
"id": "orlistat targets ABHD6",
"source_label": "orlistat",
"target_label": "ABHD6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.32",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3034010",
"relation": "IDG (Drug Target)",
"target": "747",
"properties": {
"id": "orlistat targets DAGLA",
"source_label": "orlistat",
"target_label": "DAGLA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Inhibition of human DAGLalpha expressed in HEK293T cell membrane using [14C]SAG substrate in detergent free solution by FRET assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3034010",
"relation": "IDG (Drug Target)",
"target": "221955",
"properties": {
"id": "orlistat targets DAGLB",
"source_label": "orlistat",
"target_label": "DAGLB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.22",
"act_comment": "Inhibition of human recombinant DAGLbeta overexpressed in african green monkey COS7 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3034010",
"relation": "IDG (Drug Target)",
"target": "3990",
"properties": {
"id": "orlistat targets LIPC",
"source_label": "orlistat",
"target_label": "LIPC",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "Inhibition of recombinant human HL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrate addition and measured every 20 secs for 10 mins by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3034010",
"relation": "IDG (Drug Target)",
"target": "9388",
"properties": {
"id": "orlistat targets LIPG",
"source_label": "orlistat",
"target_label": "LIPG",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrate addition and measured every 20 secs for 10 mins by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3034010",
"relation": "IDG (Drug Target)",
"target": "4023",
"properties": {
"id": "orlistat targets LPL",
"source_label": "orlistat",
"target_label": "LPL",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.18",
"act_comment": "Inhibition of recombinant human LPL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrate addition and measured every 20 secs for 10 mins by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3034010",
"relation": "IDG (Drug Target)",
"target": "7941",
"properties": {
"id": "orlistat targets PLA2G7",
"source_label": "orlistat",
"target_label": "PLA2G7",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Inhibition of recombinant PLA2g7 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3034010",
"relation": "IDG (Drug Target)",
"target": "5406",
"properties": {
"id": "orlistat targets PNLIP",
"source_label": "orlistat",
"target_label": "PNLIP",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4601",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "orphenadrine targets ADRA2A",
"source_label": "orphenadrine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.092",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4601",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "orphenadrine targets ADRA2B",
"source_label": "orphenadrine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.063",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4601",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "orphenadrine targets CHRM1",
"source_label": "orphenadrine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.39",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4601",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "orphenadrine targets CHRM2",
"source_label": "orphenadrine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.873",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4601",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "orphenadrine targets CHRM3",
"source_label": "orphenadrine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.432",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4601",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "orphenadrine targets CHRM4",
"source_label": "orphenadrine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4601",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "orphenadrine targets CHRM5",
"source_label": "orphenadrine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.699",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4601",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "orphenadrine targets CYP2D6",
"source_label": "orphenadrine",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.398",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4601",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "orphenadrine targets HRH1",
"source_label": "orphenadrine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.959",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4601",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "orphenadrine targets HTR2A",
"source_label": "orphenadrine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.903",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4601",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "orphenadrine targets HTR2C",
"source_label": "orphenadrine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.553",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4601",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "orphenadrine targets HTR6",
"source_label": "orphenadrine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.283",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4601",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "orphenadrine targets SLC6A4",
"source_label": "orphenadrine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.614",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6196",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "oxacillin targets PTGS1",
"source_label": "oxacillin",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.02",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4614",
"relation": "IDG (Drug Target)",
"target": "727",
"properties": {
"id": "oxaprozin targets C5",
"source_label": "oxaprozin",
"target_label": "C5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Binding affinity to human C5a assessed as dissociation constant after 1 hr by circular dichroism analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4614",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "oxaprozin targets PTGS1",
"source_label": "oxaprozin",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.068",
"act_comment": "DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4615",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "oxatomide targets CHRM1",
"source_label": "oxatomide",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4615",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "oxatomide targets DRD3",
"source_label": "oxatomide",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.203",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4615",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "oxatomide targets HRH1",
"source_label": "oxatomide",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.699",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4615",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "oxatomide targets HTR2A",
"source_label": "oxatomide",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.056",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4615",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "oxatomide targets HTR2B",
"source_label": "oxatomide",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.148",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4631",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "oxprenolol targets ADRB1",
"source_label": "oxprenolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.11",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4631",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "oxprenolol targets ADRB2",
"source_label": "oxprenolol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4634",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "oxybutynin targets CHRM1",
"source_label": "oxybutynin",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M1 receptor expressed in Sf9 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4634",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "oxybutynin targets CHRM2",
"source_label": "oxybutynin",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.09",
"act_comment": "Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4634",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "oxybutynin targets CHRM3",
"source_label": "oxybutynin",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.11",
"act_comment": "Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4634",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "oxybutynin targets CHRM4",
"source_label": "oxybutynin",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.44",
"act_comment": "Displacement of [3H]N-methylscopolamine from human muscarinic M4 receptor expressed in CHO cells after 120 mins by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4634",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "oxybutynin targets CHRM5",
"source_label": "oxybutynin",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Displacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO cells after 120 mins by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4634",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "oxybutynin targets CYP2C19",
"source_label": "oxybutynin",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.222",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4634",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "oxybutynin targets DRD3",
"source_label": "oxybutynin",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.837",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4634",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "oxybutynin targets HTR2B",
"source_label": "oxybutynin",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.298",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4634",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "oxybutynin targets SIGMAR1",
"source_label": "oxybutynin",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.991",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4634",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "oxybutynin targets SLC6A3",
"source_label": "oxybutynin",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.168",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5284603",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "oxycodone targets OPRM1",
"source_label": "oxycodone",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4636",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "oxymetazoline targets ADRA1A",
"source_label": "oxymetazoline",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4636",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "oxymetazoline targets ADRA1B",
"source_label": "oxymetazoline",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4636",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "oxymetazoline targets ADRA1D",
"source_label": "oxymetazoline",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4636",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "oxymetazoline targets ADRA2A",
"source_label": "oxymetazoline",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.54",
"act_comment": "Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4636",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "oxymetazoline targets ADRA2B",
"source_label": "oxymetazoline",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4636",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "oxymetazoline targets ADRA2C",
"source_label": "oxymetazoline",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "Displacement of [125I]Clonidine from adrenergic alpha2C receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4636",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "oxymetazoline targets CHRM4",
"source_label": "oxymetazoline",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.342",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4636",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "oxymetazoline targets CHRM5",
"source_label": "oxymetazoline",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.019",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4636",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "oxymetazoline targets CYP2D6",
"source_label": "oxymetazoline",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.699",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4636",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "oxymetazoline targets HTR1A",
"source_label": "oxymetazoline",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.493",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4636",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "oxymetazoline targets HTR1B",
"source_label": "oxymetazoline",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.52",
"act_comment": "Binding affinity towards human 5-hydroxytryptamine 1B receptor using [3H]5-HT trifluoroacetate as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4636",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "oxymetazoline targets HTR1D",
"source_label": "oxymetazoline",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4636",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "oxymetazoline targets HTR1E",
"source_label": "oxymetazoline",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.379",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4636",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "oxymetazoline targets HTR2A",
"source_label": "oxymetazoline",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4636",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "oxymetazoline targets HTR2B",
"source_label": "oxymetazoline",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.83",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4636",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "oxymetazoline targets HTR2C",
"source_label": "oxymetazoline",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4636",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "oxymetazoline targets HTR6",
"source_label": "oxymetazoline",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.111",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4636",
"relation": "IDG (Drug Target)",
"target": "11188",
"properties": {
"id": "oxymetazoline targets NISCH",
"source_label": "oxymetazoline",
"target_label": "NISCH",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.21",
"act_comment": "Displacement of [125I]PIC from human imidazoline receptor 1 in human platelets analyzed under norepinephrine mask of alpha 2AR",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284604",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "oxymorphone targets OPRD1",
"source_label": "oxymorphone",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Inhibitory binding constant in guinea pig brain homogenate was reported at Opioid receptor delta 1 at a a temperature 25 degree Celsius labeled with [3H](D-Ala2-D-Leu5)-enkephalin (0.7 nM)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284604",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "oxymorphone targets OPRK1",
"source_label": "oxymorphone",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.83",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5284604",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "oxymorphone targets OPRM1",
"source_label": "oxymorphone",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.444",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4641",
"relation": "IDG (Drug Target)",
"target": "93100",
"properties": {
"id": "oxyphenbutazone targets NAPRT",
"source_label": "oxyphenbutazone",
"target_label": "NAPRT",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.52",
"act_comment": "Inhibition of NAPRT (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5749",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "oxyphenonium targets CHRM4",
"source_label": "oxyphenonium",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.84",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:439302",
"relation": "IDG (Drug Target)",
"target": "552",
"properties": {
"id": "oxytocin targets AVPR1A",
"source_label": "oxytocin",
"target_label": "AVPR1A",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.91",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:439302",
"relation": "IDG (Drug Target)",
"target": "553",
"properties": {
"id": "oxytocin targets AVPR1B",
"source_label": "oxytocin",
"target_label": "AVPR1B",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:439302",
"relation": "IDG (Drug Target)",
"target": "554",
"properties": {
"id": "oxytocin targets AVPR2",
"source_label": "oxytocin",
"target_label": "AVPR2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:439302",
"relation": "IDG (Drug Target)",
"target": "5021",
"properties": {
"id": "oxytocin targets OXTR",
"source_label": "oxytocin",
"target_label": "OXTR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "Binding affinity for human oxytocin receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5282440",
"relation": "IDG (Drug Target)",
"target": "6916",
"properties": {
"id": "ozagrel targets TBXAS1",
"source_label": "ozagrel",
"target_label": "TBXAS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Inhibitory activity against human thromboxane synthetase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:441276",
"relation": "IDG (Drug Target)",
"target": "203068",
"properties": {
"id": "paclitaxel targets TUBB",
"source_label": "paclitaxel",
"target_label": "TUBB",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:441276",
"relation": "IDG (Drug Target)",
"target": "10381",
"properties": {
"id": "paclitaxel targets TUBB3",
"source_label": "paclitaxel",
"target_label": "TUBB3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.11",
"act_comment": "Inhibition of beta3 tubulin overexpressed in human HeLa cells after 48 hrs by SRB assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4671",
"relation": "IDG (Drug Target)",
"target": "9290",
"properties": {
"id": "palmidrol targets GPR55",
"source_label": "palmidrol",
"target_label": "GPR55",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6337614",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "palonosetron targets HTR3A",
"source_label": "palonosetron",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.5",
"act_comment": "Binding affinity to 5HT3A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4674",
"relation": "IDG (Drug Target)",
"target": "2224",
"properties": {
"id": "pamidronic acid targets FDPS",
"source_label": "pamidronic acid",
"target_label": "FDPS",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.25",
"act_comment": "Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4680",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "papaverine targets CYP2C19",
"source_label": "papaverine",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.118",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4680",
"relation": "IDG (Drug Target)",
"target": "10846",
"properties": {
"id": "papaverine targets PDE10A",
"source_label": "papaverine",
"target_label": "PDE10A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4680",
"relation": "IDG (Drug Target)",
"target": "5139",
"properties": {
"id": "papaverine targets PDE3A",
"source_label": "papaverine",
"target_label": "PDE3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Inhibition of human recombinant PDE3A transfected in Sf9 cells by SPA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4680",
"relation": "IDG (Drug Target)",
"target": "5140",
"properties": {
"id": "papaverine targets PDE3B",
"source_label": "papaverine",
"target_label": "PDE3B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Inhibition of human recombinant PDE3B transfected in Sf9 cells by SPA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4680",
"relation": "IDG (Drug Target)",
"target": "5141",
"properties": {
"id": "papaverine targets PDE4A",
"source_label": "papaverine",
"target_label": "PDE4A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.088",
"act_comment": "DRUGMATRIX: Phosphodiesterase PDE4 enzyme inhibition (substrate: [3H]cAMP + cAMP)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:119828",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "parecoxib targets PTGS2",
"source_label": "parecoxib",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.301",
"act_comment": "recombinant human cyclooxygenase",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5281104",
"relation": "IDG (Drug Target)",
"target": "7421",
"properties": {
"id": "paricalcitol targets VDR",
"source_label": "paricalcitol",
"target_label": "VDR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:10947895",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "paroxetine targets CHRM1",
"source_label": "paroxetine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.456",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:10947895",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "paroxetine targets CHRM2",
"source_label": "paroxetine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.724",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:10947895",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "paroxetine targets CHRM3",
"source_label": "paroxetine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:10947895",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "paroxetine targets CHRM4",
"source_label": "paroxetine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.469",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:10947895",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "paroxetine targets CHRM5",
"source_label": "paroxetine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.051",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:10947895",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "paroxetine targets CYP2D6",
"source_label": "paroxetine",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:10947895",
"relation": "IDG (Drug Target)",
"target": "4353",
"properties": {
"id": "paroxetine targets MPO",
"source_label": "paroxetine",
"target_label": "MPO",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed by H2O2 addition measured after 5 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10947895",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "paroxetine targets SLC6A2",
"source_label": "paroxetine",
"target_label": "SLC6A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.398",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:10947895",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "paroxetine targets SLC6A3",
"source_label": "paroxetine",
"target_label": "SLC6A3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.31",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:10947895",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "paroxetine targets SLC6A4",
"source_label": "paroxetine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.4",
"act_comment": "Binding inhibition towards human serotonin transporter",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10947895",
"relation": "IDG (Drug Target)",
"target": "6869",
"properties": {
"id": "paroxetine targets TACR1",
"source_label": "paroxetine",
"target_label": "TACR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:446556",
"relation": "IDG (Drug Target)",
"target": "2348",
"properties": {
"id": "pemetrexed targets FOLR1",
"source_label": "pemetrexed",
"target_label": "FOLR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.38",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:446556",
"relation": "IDG (Drug Target)",
"target": "2350",
"properties": {
"id": "pemetrexed targets FOLR2",
"source_label": "pemetrexed",
"target_label": "FOLR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.22",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:446556",
"relation": "IDG (Drug Target)",
"target": "2618",
"properties": {
"id": "pemetrexed targets GART",
"source_label": "pemetrexed",
"target_label": "GART",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Inhibition of GARFT",
"act_source": "CHEMBL"
}
},
{
"source": "CID:446556",
"relation": "IDG (Drug Target)",
"target": "6573",
"properties": {
"id": "pemetrexed targets SLC19A1",
"source_label": "pemetrexed",
"target_label": "SLC19A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.86",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:446556",
"relation": "IDG (Drug Target)",
"target": "113235",
"properties": {
"id": "pemetrexed targets SLC46A1",
"source_label": "pemetrexed",
"target_label": "SLC46A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.03",
"act_comment": "Inhibition of [3H]MTX transport at human PCFT expressed in Chinese hamster R2 cells at pH 5.5 by Dixon plot",
"act_source": "CHEMBL"
}
},
{
"source": "CID:446556",
"relation": "IDG (Drug Target)",
"target": "7298",
"properties": {
"id": "pemetrexed targets TYMS",
"source_label": "pemetrexed",
"target_label": "TYMS",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.468",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4723",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "pemoline targets SLC6A3",
"source_label": "pemoline",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.383",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:37464",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "penbutolol targets ADRB1",
"source_label": "penbutolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:37464",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "penbutolol targets ADRB2",
"source_label": "penbutolol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:37464",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "penbutolol targets HTR1A",
"source_label": "penbutolol",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:33630",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "penfluridol targets ADRA1D",
"source_label": "penfluridol",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Displacement of [3H]Prazosin from human alpha 1D adrenergic receptor expressed in HEK cells by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33630",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "penfluridol targets ADRA2B",
"source_label": "penfluridol",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Displacement of [3H]Rauwolscine from human alpha 2B adrenergic receptor expressed in HEK293T cells by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33630",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "penfluridol targets ADRA2C",
"source_label": "penfluridol",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Displacement of [3H]Rauwolscine from human alpha 2C adrenergic receptor expressed in MDCK cells by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33630",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "penfluridol targets ADRB3",
"source_label": "penfluridol",
"target_label": "ADRB3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "Displacement of [3H]CGP12177 from human beta 3 adrenergic receptor expressed in HEK293FlpIN cells by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33630",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "penfluridol targets DRD1",
"source_label": "penfluridol",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.83",
"act_comment": "Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33630",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "penfluridol targets DRD2",
"source_label": "penfluridol",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in stable fibroblast cells by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33630",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "penfluridol targets DRD3",
"source_label": "penfluridol",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.87",
"act_comment": "Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293T cells by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33630",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "penfluridol targets DRD4",
"source_label": "penfluridol",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Displacement of [3H]N-methylspiperone from human dopamine D4 receptor by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33630",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "penfluridol targets DRD5",
"source_label": "penfluridol",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33630",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "penfluridol targets HRH1",
"source_label": "penfluridol",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33630",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "penfluridol targets HRH2",
"source_label": "penfluridol",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Displacement of [3H]Cimetidine from human H2 receptor expressed in HEK cells by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33630",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "penfluridol targets HTR1A",
"source_label": "penfluridol",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.45",
"act_comment": "Displacement of [3H]-Way100635 from human 5HT1A receptor expressed in stable CHO cell membranes by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33630",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "penfluridol targets HTR2A",
"source_label": "penfluridol",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Displacement of [3H]Ketanserin from 5-HT2A receptor (unknown origin) by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33630",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "penfluridol targets HTR2B",
"source_label": "penfluridol",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33630",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "penfluridol targets HTR5A",
"source_label": "penfluridol",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Displacement of [3H]LSD from human 5-HT5A receptor expressed in Flp-In CHO cells by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33630",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "penfluridol targets HTR6",
"source_label": "penfluridol",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK cells by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33630",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "penfluridol targets OPRK1",
"source_label": "penfluridol",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEK cells by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33630",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "penfluridol targets OPRM1",
"source_label": "penfluridol",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.06",
"act_comment": "Displacement of [3H]DAMGO from human MOR expressed in HEK cells by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9853654",
"relation": "IDG (Drug Target)",
"target": "887",
"properties": {
"id": "pentagastrin targets CCKBR",
"source_label": "pentagastrin",
"target_label": "CCKBR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.84",
"act_comment": "Inhibition of binding of [125I]-PD 142308 to CCK-B receptor was determined",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4735",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "pentamidine targets ADRA1D",
"source_label": "pentamidine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.309",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4735",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "pentamidine targets ADRA2A",
"source_label": "pentamidine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.287",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4735",
"relation": "IDG (Drug Target)",
"target": "26",
"properties": {
"id": "pentamidine targets AOC1",
"source_label": "pentamidine",
"target_label": "AOC1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Mixed type inhibition of recombinant human DAO expressed in drosophila S2 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4735",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "pentamidine targets CHRM2",
"source_label": "pentamidine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.295",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4735",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "pentamidine targets CHRM4",
"source_label": "pentamidine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.658",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4735",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "pentamidine targets HTR2A",
"source_label": "pentamidine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4735",
"relation": "IDG (Drug Target)",
"target": "4128",
"properties": {
"id": "pentamidine targets MAOA",
"source_label": "pentamidine",
"target_label": "MAOA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.101",
"act_comment": "DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4735",
"relation": "IDG (Drug Target)",
"target": "7803",
"properties": {
"id": "pentamidine targets PTP4A1",
"source_label": "pentamidine",
"target_label": "PTP4A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Inhibition of PTP4A1 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4735",
"relation": "IDG (Drug Target)",
"target": "8073",
"properties": {
"id": "pentamidine targets PTP4A2",
"source_label": "pentamidine",
"target_label": "PTP4A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Inhibition of PTP4A2 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4735",
"relation": "IDG (Drug Target)",
"target": "6285",
"properties": {
"id": "pentamidine targets S100B",
"source_label": "pentamidine",
"target_label": "S100B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding to holo-S100B protein",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4735",
"relation": "IDG (Drug Target)",
"target": "55244",
"properties": {
"id": "pentamidine targets SLC47A1",
"source_label": "pentamidine",
"target_label": "SLC47A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "Inhibition of human MATE1-mediated [14]-metformin uptake expressed in polarized MDCK2 cells after 5 mins by liquid scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:439693",
"relation": "IDG (Drug Target)",
"target": "100",
"properties": {
"id": "pentostatin targets ADA",
"source_label": "pentostatin",
"target_label": "ADA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:47811",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "pergolide targets ADRA1D",
"source_label": "pergolide",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.128",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:47811",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "pergolide targets ADRA2A",
"source_label": "pergolide",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:47811",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "pergolide targets ADRA2B",
"source_label": "pergolide",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:47811",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "pergolide targets ADRA2C",
"source_label": "pergolide",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:47811",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "pergolide targets CYP2D6",
"source_label": "pergolide",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.699",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:47811",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "pergolide targets DRD1",
"source_label": "pergolide",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:47811",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "pergolide targets DRD2",
"source_label": "pergolide",
"target_label": "DRD2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:47811",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "pergolide targets DRD3",
"source_label": "pergolide",
"target_label": "DRD3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:47811",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "pergolide targets DRD4",
"source_label": "pergolide",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.25",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:47811",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "pergolide targets DRD5",
"source_label": "pergolide",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.76",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:47811",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "pergolide targets HTR1A",
"source_label": "pergolide",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:47811",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "pergolide targets HTR1B",
"source_label": "pergolide",
"target_label": "HTR1B",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:47811",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "pergolide targets HTR1D",
"source_label": "pergolide",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:47811",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "pergolide targets HTR2A",
"source_label": "pergolide",
"target_label": "HTR2A",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:47811",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "pergolide targets HTR2B",
"source_label": "pergolide",
"target_label": "HTR2B",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:47811",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "pergolide targets HTR2C",
"source_label": "pergolide",
"target_label": "HTR2C",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:47811",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "pergolide targets HTR6",
"source_label": "pergolide",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.75",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:47811",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "pergolide targets KCNH2",
"source_label": "pergolide",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Inhibition of human ERG",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4746",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "perhexiline targets CHRM1",
"source_label": "perhexiline",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.185",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4746",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "perhexiline targets CHRM3",
"source_label": "perhexiline",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.18",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4746",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "perhexiline targets CHRM4",
"source_label": "perhexiline",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4746",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "perhexiline targets CHRM5",
"source_label": "perhexiline",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.105",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4746",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "perhexiline targets CYP2D6",
"source_label": "perhexiline",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.027",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4747",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "periciazine targets DRD1",
"source_label": "periciazine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:107807",
"relation": "IDG (Drug Target)",
"target": "1636",
"properties": {
"id": "perindopril targets ACE",
"source_label": "perindopril",
"target_label": "ACE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.82",
"act_comment": "Inhibition of ACE (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16106",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "perlapine targets DRD2",
"source_label": "perlapine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.222",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:16106",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "perlapine targets DRD3",
"source_label": "perlapine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:16106",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "perlapine targets DRD4",
"source_label": "perlapine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.523",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:16106",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "perlapine targets HTR2A",
"source_label": "perlapine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.704",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:16106",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "perlapine targets HTR6",
"source_label": "perlapine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.824",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115368",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "perospirone targets DRD2",
"source_label": "perospirone",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.22",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:115368",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "perospirone targets DRD3",
"source_label": "perospirone",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.55",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:115368",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "perospirone targets DRD4",
"source_label": "perospirone",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.05",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4748",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "perphenazine targets ADRA1A",
"source_label": "perphenazine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4748",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "perphenazine targets ADRA2A",
"source_label": "perphenazine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4748",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "perphenazine targets ADRA2B",
"source_label": "perphenazine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.979",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4748",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "perphenazine targets ADRA2C",
"source_label": "perphenazine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.07",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4748",
"relation": "IDG (Drug Target)",
"target": "316",
"properties": {
"id": "perphenazine targets AOX1",
"source_label": "perphenazine",
"target_label": "AOX1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.481",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4748",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "perphenazine targets DRD2",
"source_label": "perphenazine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.32",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4748",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "perphenazine targets DRD3",
"source_label": "perphenazine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.521",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4748",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "perphenazine targets DRD4",
"source_label": "perphenazine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.588",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4748",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "perphenazine targets HRH1",
"source_label": "perphenazine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.088",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4748",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "perphenazine targets HTR1A",
"source_label": "perphenazine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4748",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "perphenazine targets HTR2A",
"source_label": "perphenazine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.252",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4748",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "perphenazine targets HTR2C",
"source_label": "perphenazine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.879",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4748",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "perphenazine targets HTR6",
"source_label": "perphenazine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.55",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4748",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "perphenazine targets HTR7",
"source_label": "perphenazine",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.638",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:14707",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "phenazocine targets OPRD1",
"source_label": "phenazocine",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:14707",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "phenazocine targets OPRK1",
"source_label": "phenazocine",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:14707",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "phenazocine targets OPRM1",
"source_label": "phenazocine",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "Displacement of [3H]DAMGO form human mu opioid receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6468",
"relation": "IDG (Drug Target)",
"target": "5547",
"properties": {
"id": "phencyclidine targets PRCP",
"source_label": "phencyclidine",
"target_label": "PRCP",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.04",
"act_comment": "Inhibition of [3H]-TCP binding to PCP receptor obtained from tissue homogenate preparation of fresh whole rat brain minus cerebellum",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3675",
"relation": "IDG (Drug Target)",
"target": "8639",
"properties": {
"id": "phenelzine targets AOC3",
"source_label": "phenelzine",
"target_label": "AOC3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Inhibition of human recombinant VAP-1 expressed in CHO cells after 30 mins by coupled colorimetric method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3675",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "phenelzine targets CYP2C19",
"source_label": "phenelzine",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.097",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3675",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "phenelzine targets CYP2D6",
"source_label": "phenelzine",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3675",
"relation": "IDG (Drug Target)",
"target": "4128",
"properties": {
"id": "phenelzine targets MAOA",
"source_label": "phenelzine",
"target_label": "MAOA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.836",
"act_comment": "DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3675",
"relation": "IDG (Drug Target)",
"target": "4129",
"properties": {
"id": "phenelzine targets MAOB",
"source_label": "phenelzine",
"target_label": "MAOB",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.82",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4762",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "phenmetrazine targets SLC6A2",
"source_label": "phenmetrazine",
"target_label": "SLC6A2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.298",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4762",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "phenmetrazine targets SLC6A3",
"source_label": "phenmetrazine",
"target_label": "SLC6A3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.883",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4768",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "phenoxybenzamine targets ADRA1A",
"source_label": "phenoxybenzamine",
"target_label": "ADRA1A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.27",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4768",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "phenoxybenzamine targets ADRA2A",
"source_label": "phenoxybenzamine",
"target_label": "ADRA2A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4768",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "phenoxybenzamine targets ADRA2B",
"source_label": "phenoxybenzamine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.456",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5775",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "phentolamine targets ADRA1A",
"source_label": "phentolamine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.39",
"act_comment": "Binding affinity towards alpha-1A adrenergic receptor expressed in human embryonic kidney (HEK293) cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5775",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "phentolamine targets ADRA1B",
"source_label": "phentolamine",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.32",
"act_comment": "Binding affinity towards human alpha-1B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5775",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "phentolamine targets ADRA1D",
"source_label": "phentolamine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.71",
"act_comment": "Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5775",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "phentolamine targets ADRA2A",
"source_label": "phentolamine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.77",
"act_comment": "Displacement of [3H]RX781094 from alpha2 adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5775",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "phentolamine targets ADRA2B",
"source_label": "phentolamine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.12",
"act_comment": "Binding affinity against Alpha-2B adrenergic receptor from human clones.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5775",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "phentolamine targets ADRA2C",
"source_label": "phentolamine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.08",
"act_comment": "Binding affinity against Alpha-2C adrenergic receptor from human clones.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5775",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "phentolamine targets HTR2C",
"source_label": "phentolamine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.684",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5775",
"relation": "IDG (Drug Target)",
"target": "11188",
"properties": {
"id": "phentolamine targets NISCH",
"source_label": "phentolamine",
"target_label": "NISCH",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.94",
"act_comment": "Displacement of [125I]PIC from human imidazoline receptor 1 in human platelets analyzed under norepinephrine mask of alpha 2AR",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5775",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "phentolamine targets SIGMAR1",
"source_label": "phentolamine",
"target_label": "SIGMAR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "The compound was tested for affinity towards sigma-3 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4781",
"relation": "IDG (Drug Target)",
"target": "93100",
"properties": {
"id": "phenylbutazone targets NAPRT",
"source_label": "phenylbutazone",
"target_label": "NAPRT",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.0",
"act_comment": "Inhibition of NAPRT (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6041",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "phenylephrine targets ADRA1B",
"source_label": "phenylephrine",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4786",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "phenylpropanolamine targets ADRA2A",
"source_label": "phenylpropanolamine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.56",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:7077",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "phenyltoloxamine targets DRD1",
"source_label": "phenyltoloxamine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Binding affinity for human recombinant dopamine receptor D1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:7077",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "phenyltoloxamine targets DRD5",
"source_label": "phenyltoloxamine",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Binding affinity for human recombinant dopamine receptor D5",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5983",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "physostigmine targets ACHE",
"source_label": "physostigmine",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.37",
"act_comment": "In vitro inhibitory activity against acetylcholinesterase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5983",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "physostigmine targets CYP2D6",
"source_label": "physostigmine",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.699",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5910",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "pilocarpine targets CHRM1",
"source_label": "pilocarpine",
"target_label": "CHRM1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.02",
"act_comment": "calcium response in CHO cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5910",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "pilocarpine targets CHRM2",
"source_label": "pilocarpine",
"target_label": "CHRM2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.95",
"act_comment": "calcium response in CHO cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5910",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "pilocarpine targets CHRM3",
"source_label": "pilocarpine",
"target_label": "CHRM3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.97",
"act_comment": "calcium response in CHO cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5910",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "pilocarpine targets CHRM4",
"source_label": "pilocarpine",
"target_label": "CHRM4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "calcium response in CHO cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5910",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "pilocarpine targets CHRM5",
"source_label": "pilocarpine",
"target_label": "CHRM5",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "calcium response in CHO cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:6509979",
"relation": "IDG (Drug Target)",
"target": "2280",
"properties": {
"id": "pimecrolimus targets FKBP1A",
"source_label": "pimecrolimus",
"target_label": "FKBP1A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "4363",
"properties": {
"id": "pimozide targets ABCC1",
"source_label": "pimozide",
"target_label": "ABCC1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "pimozide targets ADRA1A",
"source_label": "pimozide",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.704",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "pimozide targets ADRA2B",
"source_label": "pimozide",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.086",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "pimozide targets ADRA2C",
"source_label": "pimozide",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.424",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "8913",
"properties": {
"id": "pimozide targets CACNA1G",
"source_label": "pimozide",
"target_label": "CACNA1G",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "Inhibition of T-type alpha1G calcium channel",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "8911",
"properties": {
"id": "pimozide targets CACNA1I",
"source_label": "pimozide",
"target_label": "CACNA1I",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "pimozide targets DRD2",
"source_label": "pimozide",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.862",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "pimozide targets DRD3",
"source_label": "pimozide",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.046",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "pimozide targets DRD4",
"source_label": "pimozide",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.745",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "pimozide targets HRH1",
"source_label": "pimozide",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.71",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "pimozide targets HTR1A",
"source_label": "pimozide",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.63",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "pimozide targets HTR2A",
"source_label": "pimozide",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.559",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "pimozide targets HTR2C",
"source_label": "pimozide",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.058",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "pimozide targets HTR6",
"source_label": "pimozide",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.149",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "pimozide targets HTR7",
"source_label": "pimozide",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.301",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "3744",
"properties": {
"id": "pimozide targets KCNA10",
"source_label": "pimozide",
"target_label": "KCNA10",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "pimozide targets KCNH2",
"source_label": "pimozide",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.745",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "pimozide targets OPRK1",
"source_label": "pimozide",
"target_label": "OPRK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding affinity against opioid receptor kappa 1 by using [3H]U-69593 as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "pimozide targets OPRM1",
"source_label": "pimozide",
"target_label": "OPRM1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.43",
"act_comment": "Binding affinity against mu opioid receptor using [3H]DAMGO",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16362",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "pimozide targets SIGMAR1",
"source_label": "pimozide",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.842",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4828",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "pindolol targets ADRB1",
"source_label": "pindolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4828",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "pindolol targets ADRB2",
"source_label": "pindolol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4828",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "pindolol targets ADRB3",
"source_label": "pindolol",
"target_label": "ADRB3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.78",
"act_comment": "Displacement of [3H]-CGP 12177 from human beta-3 adrenergic receptor expressed in CHOK1 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4828",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "pindolol targets HTR1A",
"source_label": "pindolol",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4828",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "pindolol targets HTR1B",
"source_label": "pindolol",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4829",
"relation": "IDG (Drug Target)",
"target": "8647",
"properties": {
"id": "pioglitazone targets ABCB11",
"source_label": "pioglitazone",
"target_label": "ABCB11",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4829",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "pioglitazone targets CA2",
"source_label": "pioglitazone",
"target_label": "CA2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.943",
"act_comment": "DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA))",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4829",
"relation": "IDG (Drug Target)",
"target": "55847",
"properties": {
"id": "pioglitazone targets CISD1",
"source_label": "pioglitazone",
"target_label": "CISD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.43",
"act_comment": "Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by Cheng-Prusoff analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4829",
"relation": "IDG (Drug Target)",
"target": "4129",
"properties": {
"id": "pioglitazone targets MAOB",
"source_label": "pioglitazone",
"target_label": "MAOB",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Competitive inhibition of human MAOB expressed in Pichia pastoris",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4829",
"relation": "IDG (Drug Target)",
"target": "5468",
"properties": {
"id": "pioglitazone targets PPARG",
"source_label": "pioglitazone",
"target_label": "PPARG",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.23",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6761",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "pipamazine targets ADRA1D",
"source_label": "pipamazine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.02",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6761",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "pipamazine targets ADRA2A",
"source_label": "pipamazine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.602",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6761",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "pipamazine targets ADRA2B",
"source_label": "pipamazine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.105",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6761",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "pipamazine targets ADRA2C",
"source_label": "pipamazine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.189",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6761",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "pipamazine targets CYP2D6",
"source_label": "pipamazine",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6761",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "pipamazine targets DRD1",
"source_label": "pipamazine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6761",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "pipamazine targets DRD2",
"source_label": "pipamazine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.87",
"act_comment": "DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6761",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "pipamazine targets DRD3",
"source_label": "pipamazine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.799",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6761",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "pipamazine targets HRH1",
"source_label": "pipamazine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.939",
"act_comment": "DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6761",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "pipamazine targets HTR2A",
"source_label": "pipamazine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.256",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6761",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "pipamazine targets HTR2B",
"source_label": "pipamazine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.509",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6761",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "pipamazine targets HTR2C",
"source_label": "pipamazine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.959",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6761",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "pipamazine targets HTR6",
"source_label": "pipamazine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.284",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6761",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "pipamazine targets SIGMAR1",
"source_label": "pipamazine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.319",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6761",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "pipamazine targets SLC6A2",
"source_label": "pipamazine",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.351",
"act_comment": "DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6761",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "pipamazine targets SLC6A4",
"source_label": "pipamazine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.461",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4830",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "pipamperone targets ADRA2A",
"source_label": "pipamperone",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.066",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4830",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "pipamperone targets ADRA2B",
"source_label": "pipamperone",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.456",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4830",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "pipamperone targets ADRA2C",
"source_label": "pipamperone",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.538",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4830",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "pipamperone targets DRD2",
"source_label": "pipamperone",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.94",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4830",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "pipamperone targets DRD3",
"source_label": "pipamperone",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.602",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4830",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "pipamperone targets HTR1B",
"source_label": "pipamperone",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4830",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "pipamperone targets HTR1D",
"source_label": "pipamperone",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4830",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "pipamperone targets HTR2A",
"source_label": "pipamperone",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4830",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "pipamperone targets HTR2B",
"source_label": "pipamperone",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.324",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4830",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "pipamperone targets HTR2C",
"source_label": "pipamperone",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.644",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:37767",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "pipotiazine palmitate targets DRD2",
"source_label": "pipotiazine palmitate",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.699",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:37767",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "pipotiazine palmitate targets DRD3",
"source_label": "pipotiazine palmitate",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.553",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4848",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "pirenzepine targets ADORA3",
"source_label": "pirenzepine",
"target_label": "ADORA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.66",
"act_comment": "Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4848",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "pirenzepine targets CHRM1",
"source_label": "pirenzepine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.68",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4848",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "pirenzepine targets CHRM2",
"source_label": "pirenzepine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.76",
"act_comment": "Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4848",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "pirenzepine targets CHRM3",
"source_label": "pirenzepine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.61",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4848",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "pirenzepine targets CHRM4",
"source_label": "pirenzepine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.12",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4848",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "pirenzepine targets CHRM5",
"source_label": "pirenzepine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4849",
"relation": "IDG (Drug Target)",
"target": "6557",
"properties": {
"id": "piretanide targets SLC12A1",
"source_label": "piretanide",
"target_label": "SLC12A1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4850",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "piribedil targets ADRA1A",
"source_label": "piribedil",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4850",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "piribedil targets ADRA1D",
"source_label": "piribedil",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4850",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "piribedil targets ADRA2A",
"source_label": "piribedil",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4850",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "piribedil targets ADRA2B",
"source_label": "piribedil",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4850",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "piribedil targets ADRA2C",
"source_label": "piribedil",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4850",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "piribedil targets DRD2",
"source_label": "piribedil",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4850",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "piribedil targets DRD3",
"source_label": "piribedil",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4850",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "piribedil targets DRD4",
"source_label": "piribedil",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4850",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "piribedil targets HTR1A",
"source_label": "piribedil",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:68802",
"relation": "IDG (Drug Target)",
"target": "4128",
"properties": {
"id": "pirlindole targets MAOA",
"source_label": "pirlindole",
"target_label": "MAOA",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.409",
"act_comment": "Monoamine oxidase A (human liver form) inhibitor induced spectral changes",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5282451",
"relation": "IDG (Drug Target)",
"target": "3156",
"properties": {
"id": "pitavastatin targets HMGCR",
"source_label": "pitavastatin",
"target_label": "HMGCR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.168",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:27400",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "pizotifen targets CHRM1",
"source_label": "pizotifen",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "Binding affinity to muscarinic M1 receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:27400",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "pizotifen targets DRD2",
"source_label": "pizotifen",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.62",
"act_comment": "Binding affinity to dopamine D2 receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:27400",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "pizotifen targets HTR1A",
"source_label": "pizotifen",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:27400",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "pizotifen targets HTR2A",
"source_label": "pizotifen",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.12",
"act_comment": "Binding affinity to 5-HT2A receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:27400",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "pizotifen targets HTR2B",
"source_label": "pizotifen",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:27400",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "pizotifen targets HTR2C",
"source_label": "pizotifen",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.85",
"act_comment": "Binding affinity to 5-HT2C receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:27400",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "pizotifen targets HTR7",
"source_label": "pizotifen",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4870",
"relation": "IDG (Drug Target)",
"target": "6559",
"properties": {
"id": "polythiazide targets SLC12A3",
"source_label": "polythiazide",
"target_label": "SLC12A3",
"act_type": "A2",
"act_relation": "=",
"act_value": "9.09",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:119570",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "pramipexole targets ADRA2B",
"source_label": "pramipexole",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:119570",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "pramipexole targets DRD2",
"source_label": "pramipexole",
"target_label": "DRD2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:119570",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "pramipexole targets DRD3",
"source_label": "pramipexole",
"target_label": "DRD3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.668",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:119570",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "pramipexole targets DRD4",
"source_label": "pramipexole",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.31",
"act_comment": "in vitro high binding affinity was determined on human Dopamine receptor D4 expressed in chinese hamster ovary(CHO) K-1 cells using [3H]spiperone as radioligand.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:119570",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "pramipexole targets HTR1A",
"source_label": "pramipexole",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4887",
"relation": "IDG (Drug Target)",
"target": "10800",
"properties": {
"id": "pranlukast targets CYSLTR1",
"source_label": "pranlukast",
"target_label": "CYSLTR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:54687",
"relation": "IDG (Drug Target)",
"target": "3156",
"properties": {
"id": "pravastatin targets HMGCR",
"source_label": "pravastatin",
"target_label": "HMGCR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "Tested in vitro for the inhibition of HMG-CoA reductase from partially purified microsomal preparations.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5702106",
"relation": "IDG (Drug Target)",
"target": "6868",
"properties": {
"id": "prednisolone targets ADAM17",
"source_label": "prednisolone",
"target_label": "ADAM17",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.83",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5702106",
"relation": "IDG (Drug Target)",
"target": "2752",
"properties": {
"id": "prednisolone targets GLUL",
"source_label": "prednisolone",
"target_label": "GLUL",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.49",
"act_comment": "Ability to induce human glutamine synthetase in skeletal muscle cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5702106",
"relation": "IDG (Drug Target)",
"target": "151306",
"properties": {
"id": "prednisolone targets GPBAR1",
"source_label": "prednisolone",
"target_label": "GPBAR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Agonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha release",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5702106",
"relation": "IDG (Drug Target)",
"target": "3569",
"properties": {
"id": "prednisolone targets IL6",
"source_label": "prednisolone",
"target_label": "IL6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.38",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5702106",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "prednisolone targets NR3C1",
"source_label": "prednisolone",
"target_label": "NR3C1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5702106",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "prednisolone targets NR3C2",
"source_label": "prednisolone",
"target_label": "NR3C2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.54",
"act_comment": "Displacement of [3H]-aldosterone from human mineralocorticoid receptor expressed in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5702106",
"relation": "IDG (Drug Target)",
"target": "866",
"properties": {
"id": "prednisolone targets SERPINA6",
"source_label": "prednisolone",
"target_label": "SERPINA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.51",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:93055",
"relation": "IDG (Drug Target)",
"target": "6868",
"properties": {
"id": "prednisolone tebutate targets ADAM17",
"source_label": "prednisolone tebutate",
"target_label": "ADAM17",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.83",
"act_comment": "Fluorescence Polarization Ligand Binding Assay: The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-length glucocorticoid (GR) protein. Reagents for this assay are purchased from Invitrogen in a test kit. A fluorescent labeled GR ligand is used as a fluorescent tracer and test compounds compete with the fluorescent tracer for GR binding. The change in polarization value in the presence of test compounds is due to binding of test compounds to GR and is used to determine IC50 and relative binding affinity of test compounds for GR.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:93055",
"relation": "IDG (Drug Target)",
"target": "2752",
"properties": {
"id": "prednisolone tebutate targets GLUL",
"source_label": "prednisolone tebutate",
"target_label": "GLUL",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "Ability to induce human glutamine synthetase in skeletal muscle cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:93055",
"relation": "IDG (Drug Target)",
"target": "151306",
"properties": {
"id": "prednisolone tebutate targets GPBAR1",
"source_label": "prednisolone tebutate",
"target_label": "GPBAR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Agonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha release",
"act_source": "CHEMBL"
}
},
{
"source": "CID:93055",
"relation": "IDG (Drug Target)",
"target": "3569",
"properties": {
"id": "prednisolone tebutate targets IL6",
"source_label": "prednisolone tebutate",
"target_label": "IL6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.38",
"act_comment": "Fluorescence Polarization Ligand Binding Assay: The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-length glucocorticoid (GR) protein. Reagents for this assay are purchased from Invitrogen in a test kit. A fluorescent labeled GR ligand is used as a fluorescent tracer and test compounds compete with the fluorescent tracer for GR binding. The change in polarization value in the presence of test compounds is due to binding of test compounds to GR and is used to determine IC50 and relative binding affinity of test compounds for GR.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:93055",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "prednisolone tebutate targets NR3C1",
"source_label": "prednisolone tebutate",
"target_label": "NR3C1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.28",
"act_comment": "BindingDB_Patents: Fluorescence Polarization Ligand Binding Assay. The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-length glucocorticoid (GR) protein. Reagents for this assay are purchased from Invitrogen in a test kit. A fluorescent labeled GR ligand is used as a fluorescent tracer and test compounds compete with the fluorescent tracer for GR binding. The change in polarization value in the presence of test compounds is due to binding of test compounds to GR and is used to determine IC50 and relative binding affinity of test compounds for GR.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:93055",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "prednisolone tebutate targets NR3C2",
"source_label": "prednisolone tebutate",
"target_label": "NR3C2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.54",
"act_comment": "Displacement of [3H]-aldosterone from human mineralocorticoid receptor expressed in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:93055",
"relation": "IDG (Drug Target)",
"target": "866",
"properties": {
"id": "prednisolone tebutate targets SERPINA6",
"source_label": "prednisolone tebutate",
"target_label": "SERPINA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.51",
"act_comment": "Binding affinity to human CBG receptor (corticosteroid-binding globulins)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5865",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "prednisone targets NR3C1",
"source_label": "prednisone",
"target_label": "NR3C1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5486971",
"relation": "IDG (Drug Target)",
"target": "781",
"properties": {
"id": "pregabalin targets CACNA2D1",
"source_label": "pregabalin",
"target_label": "CACNA2D1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.097",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5486971",
"relation": "IDG (Drug Target)",
"target": "9254",
"properties": {
"id": "pregabalin targets CACNA2D2",
"source_label": "pregabalin",
"target_label": "CACNA2D2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.26",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:10070529",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "pregnenolone succinate targets SHBG",
"source_label": "pregnenolone succinate",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:42396",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "prenalterol targets ADRB1",
"source_label": "prenalterol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4904",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "pridinol targets CHRM1",
"source_label": "pridinol",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.796",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4904",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "pridinol targets CHRM2",
"source_label": "pridinol",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.15",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4904",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "pridinol targets CHRM3",
"source_label": "pridinol",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.194",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4904",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "pridinol targets CHRM4",
"source_label": "pridinol",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.585",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4904",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "pridinol targets CHRM5",
"source_label": "pridinol",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.799",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4908",
"relation": "IDG (Drug Target)",
"target": "1544",
"properties": {
"id": "primaquine targets CYP1A2",
"source_label": "primaquine",
"target_label": "CYP1A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.739",
"act_comment": "DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4908",
"relation": "IDG (Drug Target)",
"target": "3320",
"properties": {
"id": "primaquine targets HSP90AA1",
"source_label": "primaquine",
"target_label": "HSP90AA1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.222",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4908",
"relation": "IDG (Drug Target)",
"target": "6472",
"properties": {
"id": "primaquine targets SHMT2",
"source_label": "primaquine",
"target_label": "SHMT2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Inhibition of His-tagged human recombinant SHMT2 expressed in Escherichia coli BLR(DE3) assessed as reduction in NADPH level using L-serine, THF and NADP+ incubated for 5 mins by SHMT2-MTHFD coupled reaction based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4908",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "primaquine targets SLC6A4",
"source_label": "primaquine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.075",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4909",
"relation": "IDG (Drug Target)",
"target": "80036",
"properties": {
"id": "primidone targets TRPM3",
"source_label": "primidone",
"target_label": "TRPM3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4911",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "probenecid targets CA2",
"source_label": "probenecid",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4911",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "probenecid targets CA9",
"source_label": "probenecid",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4912",
"relation": "IDG (Drug Target)",
"target": "3249",
"properties": {
"id": "probucol targets HPN",
"source_label": "probucol",
"target_label": "HPN",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "High-Throughput Screening Assay: To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleavage of the chromogenic peptide. In addition, the NINDS II library of 1040 compounds (MicroSource Discovery) was screened to identify hepsin inhibitors among established drugs and known bioactive molecules. Screens were performed in a 96-well format at a final compound concentration of 2 uM. To minimize false positives, positions 1 and 12 of each row contained DMSO/buffer controls. As a measure of reproducibility, the Z' score for this assay was 0.78 (Zhang et al., 1999 J Biomol Screen 4:67).",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4913",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "procainamide targets ACHE",
"source_label": "procainamide",
"target_label": "ACHE",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4913",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "procainamide targets CHRM2",
"source_label": "procainamide",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.812",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:688561",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "procaterol targets ADRB2",
"source_label": "procaterol",
"target_label": "ADRB2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.43",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "prochlorperazine targets ADRA1A",
"source_label": "prochlorperazine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.622",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "prochlorperazine targets ADRA1D",
"source_label": "prochlorperazine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.886",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "prochlorperazine targets ADRA2A",
"source_label": "prochlorperazine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.201",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "prochlorperazine targets ADRA2B",
"source_label": "prochlorperazine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.324",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "prochlorperazine targets ADRA2C",
"source_label": "prochlorperazine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.921",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "prochlorperazine targets CHRM1",
"source_label": "prochlorperazine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.613",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "prochlorperazine targets CHRM3",
"source_label": "prochlorperazine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.493",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "prochlorperazine targets CHRM4",
"source_label": "prochlorperazine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.721",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "prochlorperazine targets CHRM5",
"source_label": "prochlorperazine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.801",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "prochlorperazine targets CYP2D6",
"source_label": "prochlorperazine",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.523",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "prochlorperazine targets DRD1",
"source_label": "prochlorperazine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.108",
"act_comment": "DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "prochlorperazine targets DRD2",
"source_label": "prochlorperazine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.764",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "prochlorperazine targets DRD3",
"source_label": "prochlorperazine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.611",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "prochlorperazine targets DRD4",
"source_label": "prochlorperazine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.17",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "prochlorperazine targets HRH1",
"source_label": "prochlorperazine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.723",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "prochlorperazine targets HTR2A",
"source_label": "prochlorperazine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.824",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "prochlorperazine targets HTR2B",
"source_label": "prochlorperazine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.187",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "prochlorperazine targets HTR2C",
"source_label": "prochlorperazine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.914",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "prochlorperazine targets HTR6",
"source_label": "prochlorperazine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.907",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "prochlorperazine targets SIGMAR1",
"source_label": "prochlorperazine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.638",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "prochlorperazine targets SLC6A2",
"source_label": "prochlorperazine",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.402",
"act_comment": "DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4917",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "prochlorperazine targets SLC6A4",
"source_label": "prochlorperazine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.207",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4919",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "procyclidine targets CHRM1",
"source_label": "procyclidine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.337",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4919",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "procyclidine targets CHRM2",
"source_label": "procyclidine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.602",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4919",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "procyclidine targets CHRM3",
"source_label": "procyclidine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.907",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4919",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "procyclidine targets CHRM4",
"source_label": "procyclidine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.155",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4919",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "procyclidine targets CHRM5",
"source_label": "procyclidine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.62",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5994",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "progesterone targets AR",
"source_label": "progesterone",
"target_label": "AR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.07",
"act_comment": "Displacement of DHT from human androgen receptor expressed in baculovirus SF-12 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5994",
"relation": "IDG (Drug Target)",
"target": "117144",
"properties": {
"id": "progesterone targets CATSPER1",
"source_label": "progesterone",
"target_label": "CATSPER1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.11",
"act_comment": "Patch clamp electrophysiology, kinetic rapid mixing fluorometry, 2-3 µM shows the saturating efficacy.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5994",
"relation": "IDG (Drug Target)",
"target": "117155",
"properties": {
"id": "progesterone targets CATSPER2",
"source_label": "progesterone",
"target_label": "CATSPER2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.11",
"act_comment": "Patch clamp electrophysiology, kinetic rapid mixing fluorometry; 2-3 µM shows the saturating efficacy.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5994",
"relation": "IDG (Drug Target)",
"target": "347732",
"properties": {
"id": "progesterone targets CATSPER3",
"source_label": "progesterone",
"target_label": "CATSPER3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.11",
"act_comment": "Patch clamp electrophysiology, kinetic rapid mixing fluorometry, 2-3µM shows the saturating efficacy.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5994",
"relation": "IDG (Drug Target)",
"target": "378807",
"properties": {
"id": "progesterone targets CATSPER4",
"source_label": "progesterone",
"target_label": "CATSPER4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.11",
"act_comment": "Patch clamp electrophysiology, kinetic rapid mixing fluorometry, 2-3µM shows the saturating efficacy.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5994",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "progesterone targets NR3C1",
"source_label": "progesterone",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "Displacement of Dexamethasone from human glucocorticoid receptor expressed in baculovirus SF-12 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5994",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "progesterone targets NR3C2",
"source_label": "progesterone",
"target_label": "NR3C2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "11.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5994",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "progesterone targets PGR",
"source_label": "progesterone",
"target_label": "PGR",
"act_type": "ED50",
"act_relation": "=",
"act_value": "9.876",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5994",
"relation": "IDG (Drug Target)",
"target": "866",
"properties": {
"id": "progesterone targets SERPINA6",
"source_label": "progesterone",
"target_label": "SERPINA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.38",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5994",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "progesterone targets SHBG",
"source_label": "progesterone",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.94",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5994",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "progesterone targets SIGMAR1",
"source_label": "progesterone",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "promazine targets ADRA1A",
"source_label": "promazine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.226",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "promazine targets ADRA1D",
"source_label": "promazine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.427",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "promazine targets ADRA2A",
"source_label": "promazine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "promazine targets ADRA2B",
"source_label": "promazine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "promazine targets ADRA2C",
"source_label": "promazine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.432",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "promazine targets CHRM1",
"source_label": "promazine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.825",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "promazine targets CHRM2",
"source_label": "promazine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.412",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "promazine targets CHRM3",
"source_label": "promazine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.056",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "promazine targets CHRM4",
"source_label": "promazine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.377",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "promazine targets CHRM5",
"source_label": "promazine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.337",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "promazine targets CYP2D6",
"source_label": "promazine",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.523",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "promazine targets DRD2",
"source_label": "promazine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.704",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "promazine targets DRD3",
"source_label": "promazine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.799",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "promazine targets HRH1",
"source_label": "promazine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.699",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "promazine targets HTR2A",
"source_label": "promazine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "promazine targets HTR2B",
"source_label": "promazine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.656",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "promazine targets HTR2C",
"source_label": "promazine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.284",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "promazine targets HTR6",
"source_label": "promazine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.896",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "promazine targets SIGMAR1",
"source_label": "promazine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.943",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "promazine targets SLC6A2",
"source_label": "promazine",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.886",
"act_comment": "DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4926",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "promazine targets SLC6A4",
"source_label": "promazine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.337",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:36709",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "promegestone targets PGR",
"source_label": "promegestone",
"target_label": "PGR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "Binding affinity to progesterone receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "promethazine targets ADRA1D",
"source_label": "promethazine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.495",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "promethazine targets ADRA2A",
"source_label": "promethazine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.592",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "promethazine targets ADRA2B",
"source_label": "promethazine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.62",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "promethazine targets ADRA2C",
"source_label": "promethazine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.452",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "316",
"properties": {
"id": "promethazine targets AOX1",
"source_label": "promethazine",
"target_label": "AOX1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.292",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "590",
"properties": {
"id": "promethazine targets BCHE",
"source_label": "promethazine",
"target_label": "BCHE",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "promethazine targets CHRM1",
"source_label": "promethazine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.479",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "promethazine targets CHRM2",
"source_label": "promethazine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.921",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "promethazine targets CHRM3",
"source_label": "promethazine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.382",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "promethazine targets CHRM4",
"source_label": "promethazine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.975",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "promethazine targets CHRM5",
"source_label": "promethazine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.48",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "promethazine targets DRD2",
"source_label": "promethazine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.609",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "promethazine targets DRD3",
"source_label": "promethazine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.721",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "2671",
"properties": {
"id": "promethazine targets GFER",
"source_label": "promethazine",
"target_label": "GFER",
"act_type": "AC50",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787]",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "promethazine targets HRH1",
"source_label": "promethazine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.62",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "59340",
"properties": {
"id": "promethazine targets HRH4",
"source_label": "promethazine",
"target_label": "HRH4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.823",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "promethazine targets HTR2A",
"source_label": "promethazine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "promethazine targets HTR2B",
"source_label": "promethazine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.367",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "promethazine targets HTR2C",
"source_label": "promethazine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.188",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4927",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "promethazine targets SIGMAR1",
"source_label": "promethazine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.921",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4932",
"relation": "IDG (Drug Target)",
"target": "5243",
"properties": {
"id": "propafenone targets ABCB1",
"source_label": "propafenone",
"target_label": "ABCB1",
"act_type": "ED50",
"act_relation": "=",
"act_value": "7.056",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4932",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "propafenone targets ADRB1",
"source_label": "propafenone",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.688",
"act_comment": "DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4932",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "propafenone targets ADRB2",
"source_label": "propafenone",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.444",
"act_comment": "DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4932",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "propafenone targets ADRB3",
"source_label": "propafenone",
"target_label": "ADRB3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.498",
"act_comment": "DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4932",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "propafenone targets HTR1A",
"source_label": "propafenone",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.029",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4932",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "propafenone targets HTR2A",
"source_label": "propafenone",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.728",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4932",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "propafenone targets HTR2B",
"source_label": "propafenone",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.237",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4932",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "propafenone targets HTR2C",
"source_label": "propafenone",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.697",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4932",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "propafenone targets HTR6",
"source_label": "propafenone",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.063",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4932",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "propafenone targets KCNH2",
"source_label": "propafenone",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.097",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4934",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "propantheline targets CHRM1",
"source_label": "propantheline",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4934",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "propantheline targets CHRM2",
"source_label": "propantheline",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4934",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "propantheline targets CHRM3",
"source_label": "propantheline",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4934",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "propantheline targets CHRM4",
"source_label": "propantheline",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4935",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "proparacaine targets SIGMAR1",
"source_label": "proparacaine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4946",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "propranolol targets ADRB1",
"source_label": "propranolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.71",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4946",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "propranolol targets ADRB2",
"source_label": "propranolol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.25",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4946",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "propranolol targets ADRB3",
"source_label": "propranolol",
"target_label": "ADRB3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4946",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "propranolol targets HTR1A",
"source_label": "propranolol",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.913",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4946",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "propranolol targets HTR1B",
"source_label": "propranolol",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.197",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4946",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "propranolol targets HTR2B",
"source_label": "propranolol",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.662",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4946",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "propranolol targets SLC6A4",
"source_label": "propranolol",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.695",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:638678",
"relation": "IDG (Drug Target)",
"target": "7201",
"properties": {
"id": "protirelin targets TRHR",
"source_label": "protirelin",
"target_label": "TRHR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Displacement of [3H]N(1)-Me-His-TRH from TRHR1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4976",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "protriptyline targets ADORA3",
"source_label": "protriptyline",
"target_label": "ADORA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.96",
"act_comment": "Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4976",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "protriptyline targets CHRM1",
"source_label": "protriptyline",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4976",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "protriptyline targets CHRM2",
"source_label": "protriptyline",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4976",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "protriptyline targets CHRM3",
"source_label": "protriptyline",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4976",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "protriptyline targets CHRM4",
"source_label": "protriptyline",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.94",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4976",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "protriptyline targets CHRM5",
"source_label": "protriptyline",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.86",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4976",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "protriptyline targets HRH1",
"source_label": "protriptyline",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.22",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4976",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "protriptyline targets HTR2A",
"source_label": "protriptyline",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4976",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "protriptyline targets HTR2B",
"source_label": "protriptyline",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4976",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "protriptyline targets HTR2C",
"source_label": "protriptyline",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4976",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "protriptyline targets SLC6A2",
"source_label": "protriptyline",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.39",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4976",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "protriptyline targets SLC6A4",
"source_label": "protriptyline",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.34",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:1046",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "pyrazinamide targets CYP3A4",
"source_label": "pyrazinamide",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4991",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "pyridostigmine targets ACHE",
"source_label": "pyridostigmine",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Inhibition of human whole RBC AChE pretreated for 30 mins by Ellman technique",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4992",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "mepyramine targets ADORA3",
"source_label": "mepyramine",
"target_label": "ADORA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.89",
"act_comment": "Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4992",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "mepyramine targets CYP2D6",
"source_label": "mepyramine",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.523",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4992",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "mepyramine targets HRH1",
"source_label": "mepyramine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "GRAC: human H1 selective antagonist",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4992",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "mepyramine targets HTR2C",
"source_label": "mepyramine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.228",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4992",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "mepyramine targets SIGMAR1",
"source_label": "mepyramine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.184",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4992",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "mepyramine targets SLC6A3",
"source_label": "mepyramine",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.156",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4992",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "mepyramine targets SLC6A4",
"source_label": "mepyramine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.602",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4993",
"relation": "IDG (Drug Target)",
"target": "1719",
"properties": {
"id": "pyrimethamine targets DHFR",
"source_label": "pyrimethamine",
"target_label": "DHFR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "Cytotoxicity by selective inhibition against human dihydrofolate reductase (DHFR).",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4993",
"relation": "IDG (Drug Target)",
"target": "55244",
"properties": {
"id": "pyrimethamine targets SLC47A1",
"source_label": "pyrimethamine",
"target_label": "SLC47A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:73707346",
"relation": "IDG (Drug Target)",
"target": "8867",
"properties": {
"id": "pyrvinium targets SYNJ1",
"source_label": "pyrvinium",
"target_label": "SYNJ1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Inhibition of C-Myc/DDK-tagged human recombinant SYNJ1 expressed in HEK293T cells assessed as reduction in 5'-phosphatase activity incubated for 8 mins using fluorescently-labeled PI(3,4)P2 probe and Tapp1 PH-domain as detector protein by fluorescence polarization competitive assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "quetiapine targets ADRA1A",
"source_label": "quetiapine",
"target_label": "ADRA1A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.027",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "quetiapine targets ADRA1B",
"source_label": "quetiapine",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.409",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "quetiapine targets ADRA1D",
"source_label": "quetiapine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.457",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "quetiapine targets ADRA2B",
"source_label": "quetiapine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.127",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "quetiapine targets ADRA2C",
"source_label": "quetiapine",
"target_label": "ADRA2C",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.241",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "quetiapine targets CHRM1",
"source_label": "quetiapine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.25",
"act_comment": "Binding affinity towards human M1 receptor.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "quetiapine targets CHRM2",
"source_label": "quetiapine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.037",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "quetiapine targets CHRM4",
"source_label": "quetiapine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.266",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "quetiapine targets DRD1",
"source_label": "quetiapine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "Binding affinity against dopamine receptor D1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "quetiapine targets DRD2",
"source_label": "quetiapine",
"target_label": "DRD2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.483",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "quetiapine targets DRD3",
"source_label": "quetiapine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.49",
"act_comment": "Binding affinity to human cloned dopamine D3 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "3005",
"properties": {
"id": "quetiapine targets H1-0",
"source_label": "quetiapine",
"target_label": "H1-0",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, \u00ce\u00b1A1, 5-HT2C and H1 Receptors.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "quetiapine targets HRH1",
"source_label": "quetiapine",
"target_label": "HRH1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.35",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "quetiapine targets HTR1A",
"source_label": "quetiapine",
"target_label": "HTR1A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.83",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "quetiapine targets HTR2A",
"source_label": "quetiapine",
"target_label": "HTR2A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.131",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "quetiapine targets HTR2B",
"source_label": "quetiapine",
"target_label": "HTR2B",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.523",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "quetiapine targets HTR2C",
"source_label": "quetiapine",
"target_label": "HTR2C",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "quetiapine targets HTR7",
"source_label": "quetiapine",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.512",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "quetiapine targets SIGMAR1",
"source_label": "quetiapine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.016",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5002",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "quetiapine targets SLC6A2",
"source_label": "quetiapine",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:237",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "mepacrine targets ADRA2A",
"source_label": "mepacrine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.068",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:237",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "mepacrine targets ADRA2B",
"source_label": "mepacrine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.079",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:237",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "mepacrine targets ADRA2C",
"source_label": "mepacrine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.252",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:237",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "mepacrine targets CHRM1",
"source_label": "mepacrine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.445",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:237",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "mepacrine targets CHRM2",
"source_label": "mepacrine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.465",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:237",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "mepacrine targets CHRM3",
"source_label": "mepacrine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.575",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:237",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "mepacrine targets CHRM4",
"source_label": "mepacrine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.558",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:237",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "mepacrine targets DRD3",
"source_label": "mepacrine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.349",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:237",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "mepacrine targets HTR2A",
"source_label": "mepacrine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.119",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:237",
"relation": "IDG (Drug Target)",
"target": "5621",
"properties": {
"id": "mepacrine targets PRNP",
"source_label": "mepacrine",
"target_label": "PRNP",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:54892",
"relation": "IDG (Drug Target)",
"target": "1636",
"properties": {
"id": "quinapril targets ACE",
"source_label": "quinapril",
"target_label": "ACE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.08",
"act_comment": "Compound was tested for its inhibitory potency against angiotensin I converting enzyme.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:441074",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "quinidine targets CYP2D6",
"source_label": "quinidine",
"target_label": "CYP2D6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.921",
"act_comment": "CYP2D6 catalyzed AMMC-O-demethylation in HepG2 transfected cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:441074",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "quinidine targets KCNH2",
"source_label": "quinidine",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.49",
"act_comment": "Inhibition of human Potassium channel HERG expressed in mammalian cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5029",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "rabeprazole targets ADRA2B",
"source_label": "rabeprazole",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.101",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5029",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "rabeprazole targets DRD3",
"source_label": "rabeprazole",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.102",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "raloxifene targets ACHE",
"source_label": "raloxifene",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.398",
"act_comment": "DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "raloxifene targets ADRA1D",
"source_label": "raloxifene",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.321",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "raloxifene targets ADRA2A",
"source_label": "raloxifene",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.205",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "raloxifene targets ADRA2C",
"source_label": "raloxifene",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.971",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "316",
"properties": {
"id": "raloxifene targets AOX1",
"source_label": "raloxifene",
"target_label": "AOX1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.538",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "727",
"properties": {
"id": "raloxifene targets C5",
"source_label": "raloxifene",
"target_label": "C5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Binding affinity to human C5a assessed as dissociation constant after 1 hr by circular dichroism analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "raloxifene targets DRD2",
"source_label": "raloxifene",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.408",
"act_comment": "DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "raloxifene targets DRD3",
"source_label": "raloxifene",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.275",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "10682",
"properties": {
"id": "raloxifene targets EBP",
"source_label": "raloxifene",
"target_label": "EBP",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "raloxifene targets ESR1",
"source_label": "raloxifene",
"target_label": "ESR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "2100",
"properties": {
"id": "raloxifene targets ESR2",
"source_label": "raloxifene",
"target_label": "ESR2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "2852",
"properties": {
"id": "raloxifene targets GPER1",
"source_label": "raloxifene",
"target_label": "GPER1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "raloxifene targets HTR1D",
"source_label": "raloxifene",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.523",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "raloxifene targets HTR2A",
"source_label": "raloxifene",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.383",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "raloxifene targets HTR2B",
"source_label": "raloxifene",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.16",
"act_comment": "Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "raloxifene targets HTR2C",
"source_label": "raloxifene",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "raloxifene targets HTR6",
"source_label": "raloxifene",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "3569",
"properties": {
"id": "raloxifene targets IL6",
"source_label": "raloxifene",
"target_label": "IL6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "raloxifene targets OPRK1",
"source_label": "raloxifene",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.193",
"act_comment": "DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "raloxifene targets OPRM1",
"source_label": "raloxifene",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.321",
"act_comment": "DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "raloxifene targets SIGMAR1",
"source_label": "raloxifene",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5035",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "raloxifene targets SLC6A2",
"source_label": "raloxifene",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.553",
"act_comment": "DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:54671008",
"relation": "IDG (Drug Target)",
"target": "1230",
"properties": {
"id": "raltegravir targets CCR1",
"source_label": "raltegravir",
"target_label": "CCR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "Binding affinity to CCR1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:104758",
"relation": "IDG (Drug Target)",
"target": "2348",
"properties": {
"id": "raltitrexed targets FOLR1",
"source_label": "raltitrexed",
"target_label": "FOLR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.82",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:104758",
"relation": "IDG (Drug Target)",
"target": "2350",
"properties": {
"id": "raltitrexed targets FOLR2",
"source_label": "raltitrexed",
"target_label": "FOLR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.66",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:104758",
"relation": "IDG (Drug Target)",
"target": "6573",
"properties": {
"id": "raltitrexed targets SLC19A1",
"source_label": "raltitrexed",
"target_label": "SLC19A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:104758",
"relation": "IDG (Drug Target)",
"target": "113235",
"properties": {
"id": "raltitrexed targets SLC46A1",
"source_label": "raltitrexed",
"target_label": "SLC46A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:104758",
"relation": "IDG (Drug Target)",
"target": "7298",
"properties": {
"id": "raltitrexed targets TYMS",
"source_label": "raltitrexed",
"target_label": "TYMS",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "Inhibition of human recombinant His-tagged thymidylate synthase assessed as N5,N10-methylenetetrahydrofolate oxidation to dihydrofolate after 20 mins by UV spectrophotometric analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123879",
"relation": "IDG (Drug Target)",
"target": "11251",
"properties": {
"id": "ramatroban targets PTGDR2",
"source_label": "ramatroban",
"target_label": "PTGDR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.37",
"act_comment": "Inhibition of [3H]PGD-2 binding to human chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:123879",
"relation": "IDG (Drug Target)",
"target": "6915",
"properties": {
"id": "ramatroban targets TBXA2R",
"source_label": "ramatroban",
"target_label": "TBXA2R",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.24",
"act_comment": "Binding affinity to thromboxane receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:208902",
"relation": "IDG (Drug Target)",
"target": "4543",
"properties": {
"id": "ramelteon targets MTNR1A",
"source_label": "ramelteon",
"target_label": "MTNR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:208902",
"relation": "IDG (Drug Target)",
"target": "4544",
"properties": {
"id": "ramelteon targets MTNR1B",
"source_label": "ramelteon",
"target_label": "MTNR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.39",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5362129",
"relation": "IDG (Drug Target)",
"target": "1636",
"properties": {
"id": "ramipril targets ACE",
"source_label": "ramipril",
"target_label": "ACE",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.342",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:108000",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "ramosetron targets HTR3A",
"source_label": "ramosetron",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.22",
"act_comment": "Binding affinity to human 5HT3A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3001055",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "ranitidine targets ACHE",
"source_label": "ranitidine",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Inhibition of guinea pig acetylcholinesterase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3001055",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "ranitidine targets HRH2",
"source_label": "ranitidine",
"target_label": "HRH2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.86",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:65856",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "reboxetine targets HTR6",
"source_label": "reboxetine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.34",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:65856",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "reboxetine targets SLC6A2",
"source_label": "reboxetine",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.96",
"act_comment": "In vitro binding affinity against human norepinephrine transporter in human embryonic kidney cell line by using [3H]-nisoxatine radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65856",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "reboxetine targets SLC6A3",
"source_label": "reboxetine",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.22",
"act_comment": "In vitro competitive binding versus [N-methyl-3H]WIN-35428 in murine kidney cells transfected with cDNA for human dopamine transporter (DAT)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65856",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "reboxetine targets SLC6A4",
"source_label": "reboxetine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "In vitro competitive binding versus [3H]-citalopram in murine kidney cells transfected with cDNA for human serotonin transporter (SERT)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:54477",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "remoxipride targets DRD2",
"source_label": "remoxipride",
"target_label": "DRD2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.06",
"act_comment": "Binding affinity to dopamine receptor D2 cloned from human, using [3H]- YM09151 as competitive ligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:54477",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "remoxipride targets SIGMAR1",
"source_label": "remoxipride",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.26",
"act_comment": "Binding affinity against the sigma receptor from guinea pig brain using the radioligand [3H]SKF-10047",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65981",
"relation": "IDG (Drug Target)",
"target": "6833",
"properties": {
"id": "repaglinide targets ABCC8",
"source_label": "repaglinide",
"target_label": "ABCC8",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5770",
"relation": "IDG (Drug Target)",
"target": "5243",
"properties": {
"id": "reserpine targets ABCB1",
"source_label": "reserpine",
"target_label": "ABCB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affinity model",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5770",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "reserpine targets DRD2",
"source_label": "reserpine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.232",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5770",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "reserpine targets DRD3",
"source_label": "reserpine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.223",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5770",
"relation": "IDG (Drug Target)",
"target": "6570",
"properties": {
"id": "reserpine targets SLC18A1",
"source_label": "reserpine",
"target_label": "SLC18A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.45",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5770",
"relation": "IDG (Drug Target)",
"target": "6571",
"properties": {
"id": "reserpine targets SLC18A2",
"source_label": "reserpine",
"target_label": "SLC18A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:638034",
"relation": "IDG (Drug Target)",
"target": "5950",
"properties": {
"id": "retinol acetate targets RBP4",
"source_label": "retinol acetate",
"target_label": "RBP4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Binding affinity to His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as apparent dissociation constant after 5 mins by fluorescence spectrophotometric analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:37542",
"relation": "IDG (Drug Target)",
"target": "3614",
"properties": {
"id": "ribavirin targets IMPDH1",
"source_label": "ribavirin",
"target_label": "IMPDH1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "In vitro inhibition of IMPDH (isoform not specified, human and mouse assayed)",
"act_source": "IUPHAR"
}
},
{
"source": "CID:37542",
"relation": "IDG (Drug Target)",
"target": "3615",
"properties": {
"id": "ribavirin targets IMPDH2",
"source_label": "ribavirin",
"target_label": "IMPDH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "In vitro inhibition of IMPDH (isoform not specified, human and mouse assayed)",
"act_source": "IUPHAR"
}
},
{
"source": "CID:68712",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "rilmenidine targets ADRA2A",
"source_label": "rilmenidine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.44",
"act_comment": "Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68712",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "rilmenidine targets ADRA2B",
"source_label": "rilmenidine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.37",
"act_comment": "Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68712",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "rilmenidine targets ADRA2C",
"source_label": "rilmenidine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "Displacement of [3H]RX821001 from human alpha2C adrenoceptor expressed in CHO cells after 60 mins by gamma counter",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68712",
"relation": "IDG (Drug Target)",
"target": "11188",
"properties": {
"id": "rilmenidine targets NISCH",
"source_label": "rilmenidine",
"target_label": "NISCH",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.23",
"act_comment": "Displacement of [125I]PIC from human imidazoline receptor 1 in human platelets analyzed under norepinephrine mask of alpha 2AR",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5245",
"relation": "IDG (Drug Target)",
"target": "2224",
"properties": {
"id": "risedronic acid targets FDPS",
"source_label": "risedronic acid",
"target_label": "FDPS",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.44",
"act_comment": "Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5808",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "levisoprenaline targets ADRB1",
"source_label": "levisoprenaline",
"target_label": "ADRB1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "Agonist activity at human beta1 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5808",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "levisoprenaline targets ADRB2",
"source_label": "levisoprenaline",
"target_label": "ADRB2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.3",
"act_comment": "Mitogenesis inhibition method: To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cells/well. After 48 hours, the wells were rinsed twice and the medium was replaced with fresh medium containing 10 uL of drug in sterile water. After another 24 hours of incubation at 37\u00c2\u00b0 C., 0.25 uCi of [3H]-thymidine was added to each well. The cells were incubated for an additional 2 hours at 37\u00c2\u00b0 C., at which point 10 uL of 10x trypsin was added, and the resuspended cells were harvested using a Tomtec 96 harvester through glass fiber filters.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5808",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "levisoprenaline targets ADRB3",
"source_label": "levisoprenaline",
"target_label": "ADRB3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "Agonist activity at human beta3 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "risperidone targets ADRA1A",
"source_label": "risperidone",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.553",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "risperidone targets ADRA1B",
"source_label": "risperidone",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.48",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "risperidone targets ADRA1D",
"source_label": "risperidone",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "risperidone targets ADRA2A",
"source_label": "risperidone",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "risperidone targets ADRA2B",
"source_label": "risperidone",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "risperidone targets ADRA2C",
"source_label": "risperidone",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.495",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "risperidone targets DRD1",
"source_label": "risperidone",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.68",
"act_comment": "Binding affinity against dopamine receptor D1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "risperidone targets DRD2",
"source_label": "risperidone",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.49",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "risperidone targets DRD3",
"source_label": "risperidone",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.07",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "risperidone targets DRD4",
"source_label": "risperidone",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "risperidone targets DRD5",
"source_label": "risperidone",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.023",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "2741",
"properties": {
"id": "risperidone targets GLRA1",
"source_label": "risperidone",
"target_label": "GLRA1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.49",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "3005",
"properties": {
"id": "risperidone targets H1-0",
"source_label": "risperidone",
"target_label": "H1-0",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, \u00ce\u00b1A1, 5-HT2C and H1 Receptors.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "risperidone targets HRH1",
"source_label": "risperidone",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.481",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "risperidone targets HRH2",
"source_label": "risperidone",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.921",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "risperidone targets HTR1A",
"source_label": "risperidone",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.443",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "risperidone targets HTR1B",
"source_label": "risperidone",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.49",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "risperidone targets HTR1D",
"source_label": "risperidone",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "risperidone targets HTR2A",
"source_label": "risperidone",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.364",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "risperidone targets HTR2B",
"source_label": "risperidone",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "risperidone targets HTR2C",
"source_label": "risperidone",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "risperidone targets HTR5A",
"source_label": "risperidone",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.687",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "risperidone targets HTR6",
"source_label": "risperidone",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.65",
"act_comment": "Displacement of [3H]5-LSD from human 5HT6 receptor expressed in human HeLa cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "risperidone targets HTR7",
"source_label": "risperidone",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.47",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5073",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "risperidone targets KCNH2",
"source_label": "risperidone",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.788",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:33572",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "ritodrine targets ADRB2",
"source_label": "ritodrine",
"target_label": "ADRB2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.62",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:33572",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "ritodrine targets ADRB3",
"source_label": "ritodrine",
"target_label": "ADRB3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:392622",
"relation": "IDG (Drug Target)",
"target": "1559",
"properties": {
"id": "ritonavir targets CYP2C9",
"source_label": "ritonavir",
"target_label": "CYP2C9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:392622",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "ritonavir targets CYP3A4",
"source_label": "ritonavir",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.55",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:392622",
"relation": "IDG (Drug Target)",
"target": "1577",
"properties": {
"id": "ritonavir targets CYP3A5",
"source_label": "ritonavir",
"target_label": "CYP3A5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:392622",
"relation": "IDG (Drug Target)",
"target": "55244",
"properties": {
"id": "ritonavir targets SLC47A1",
"source_label": "ritonavir",
"target_label": "SLC47A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "Inhibition of human MATE1-mediated [14]-metformin uptake expressed in HEK293 cells after 1.5 mins by scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:392622",
"relation": "IDG (Drug Target)",
"target": "6865",
"properties": {
"id": "ritonavir targets TACR2",
"source_label": "ritonavir",
"target_label": "TACR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.058",
"act_comment": "DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:392622",
"relation": "IDG (Drug Target)",
"target": "6916",
"properties": {
"id": "ritonavir targets TBXAS1",
"source_label": "ritonavir",
"target_label": "TBXAS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.119",
"act_comment": "DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:77991",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "rivastigmine targets ACHE",
"source_label": "rivastigmine",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.43",
"act_comment": "Inhibition of human erythrocytes BChE",
"act_source": "CHEMBL"
}
},
{
"source": "CID:77991",
"relation": "IDG (Drug Target)",
"target": "590",
"properties": {
"id": "rivastigmine targets BCHE",
"source_label": "rivastigmine",
"target_label": "BCHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "Inhibition of human recombinant butyrylcholinesterase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5078",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "rizatriptan targets HTR1A",
"source_label": "rizatriptan",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5078",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "rizatriptan targets HTR1B",
"source_label": "rizatriptan",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5078",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "rizatriptan targets HTR1D",
"source_label": "rizatriptan",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5078",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "rizatriptan targets HTR1E",
"source_label": "rizatriptan",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5078",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "rizatriptan targets HTR1F",
"source_label": "rizatriptan",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5090",
"relation": "IDG (Drug Target)",
"target": "5732",
"properties": {
"id": "rofecoxib targets PTGER2",
"source_label": "rofecoxib",
"target_label": "PTGER2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.466",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5090",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "rofecoxib targets PTGS2",
"source_label": "rofecoxib",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5095",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "ropinirole targets ADRA2B",
"source_label": "ropinirole",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5095",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "ropinirole targets DRD2",
"source_label": "ropinirole",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.14",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5095",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "ropinirole targets DRD3",
"source_label": "ropinirole",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.43",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5095",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "ropinirole targets DRD4",
"source_label": "ropinirole",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5095",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "ropinirole targets HTR1A",
"source_label": "ropinirole",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5095",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "ropinirole targets HTR2A",
"source_label": "ropinirole",
"target_label": "HTR2A",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Agonist activity at 5HT2A receptor (unknown origin) expressed in mouse NIH/3T3 cells by R-SAT assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:77999",
"relation": "IDG (Drug Target)",
"target": "55847",
"properties": {
"id": "rosiglitazone targets CISD1",
"source_label": "rosiglitazone",
"target_label": "CISD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.51",
"act_comment": "Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by Cheng-Prusoff analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:77999",
"relation": "IDG (Drug Target)",
"target": "5465",
"properties": {
"id": "rosiglitazone targets PPARA",
"source_label": "rosiglitazone",
"target_label": "PPARA",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.41",
"act_comment": "Agonist activity at human PPARalpha ligand binding domain expressed in human HepG2 cells co-transfected with Gal4 by luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:77999",
"relation": "IDG (Drug Target)",
"target": "5468",
"properties": {
"id": "rosiglitazone targets PPARG",
"source_label": "rosiglitazone",
"target_label": "PPARG",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.04",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:446157",
"relation": "IDG (Drug Target)",
"target": "3156",
"properties": {
"id": "rosuvastatin targets HMGCR",
"source_label": "rosuvastatin",
"target_label": "HMGCR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.05",
"act_comment": "Inhibitory constant against HMG-CoA reductase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:59227",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "rotigotine targets DRD2",
"source_label": "rotigotine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.22",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:59227",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "rotigotine targets DRD3",
"source_label": "rotigotine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:59227",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "rotigotine targets DRD4",
"source_label": "rotigotine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.26",
"act_comment": "Binding affinity was evaluated by calculating competition for [3H]spiperone binding on Dopamine receptor D4.2 of CHO K-1 cells.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:59227",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "rotigotine targets DRD5",
"source_label": "rotigotine",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5105",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "roxatidine acetate targets HRH2",
"source_label": "roxatidine acetate",
"target_label": "HRH2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6915744",
"relation": "IDG (Drug Target)",
"target": "2862",
"properties": {
"id": "roxithromycin targets MLNR",
"source_label": "roxithromycin",
"target_label": "MLNR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:133017",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "rupatadine targets HRH1",
"source_label": "rupatadine",
"target_label": "HRH1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.41",
"act_comment": "Inhibitory concentration against histamine H1 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:338",
"relation": "IDG (Drug Target)",
"target": "3146",
"properties": {
"id": "salicylic acid targets HMGB1",
"source_label": "salicylic acid",
"target_label": "HMGB1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding affinity to recombinant HMGB1 box A (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:338",
"relation": "IDG (Drug Target)",
"target": "93100",
"properties": {
"id": "salicylic acid targets NAPRT",
"source_label": "salicylic acid",
"target_label": "NAPRT",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.8",
"act_comment": "Inhibition of NAPRT (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5152",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "salmeterol targets ADRB1",
"source_label": "salmeterol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Displacement of [3H]CGP12177 from human beta-1 adrenoceptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5152",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "salmeterol targets ADRB2",
"source_label": "salmeterol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.41",
"act_comment": "Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5152",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "salmeterol targets ADRB3",
"source_label": "salmeterol",
"target_label": "ADRB3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Agonist activity at human recombinant beta3 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5160",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "sarpogrelate targets HTR2A",
"source_label": "sarpogrelate",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5160",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "sarpogrelate targets HTR2B",
"source_label": "sarpogrelate",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5160",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "sarpogrelate targets HTR2C",
"source_label": "sarpogrelate",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3000322",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "scopolamine targets CHRM1",
"source_label": "scopolamine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3000322",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "scopolamine targets CHRM2",
"source_label": "scopolamine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.86",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3000322",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "scopolamine targets CHRM3",
"source_label": "scopolamine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3000322",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "scopolamine targets CHRM4",
"source_label": "scopolamine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.37",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:3000322",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "scopolamine targets CHRM5",
"source_label": "scopolamine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.75",
"act_comment": "Displacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:26757",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "selegiline targets ADRA2A",
"source_label": "selegiline",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.171",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26757",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "selegiline targets ADRA2B",
"source_label": "selegiline",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.764",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:26757",
"relation": "IDG (Drug Target)",
"target": "4129",
"properties": {
"id": "selegiline targets MAOB",
"source_label": "selegiline",
"target_label": "MAOB",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.26",
"act_comment": "Irreversible inhibition of recombinant human MAO-B expressed in baculovirus infected BT1 cells using benzylamine as substrate at 200 uM preincubated for 30 mins by Lineweaver-Burk plot analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2449",
"relation": "IDG (Drug Target)",
"target": "6915",
"properties": {
"id": "seratrodast targets TBXA2R",
"source_label": "seratrodast",
"target_label": "TBXA2R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.13",
"act_comment": "In vitro concentration that reduced specific binding of [3H]U-440619 to guinea pig platelet receptor, TXA2 by 50%",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "sertindole targets ADRA1A",
"source_label": "sertindole",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.745",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "sertindole targets ADRA2A",
"source_label": "sertindole",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.194",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "sertindole targets ADRA2B",
"source_label": "sertindole",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.347",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "sertindole targets ADRA2C",
"source_label": "sertindole",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.347",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "sertindole targets DRD1",
"source_label": "sertindole",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Binding affinity towards human Dopamine receptor D1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "sertindole targets DRD2",
"source_label": "sertindole",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.35",
"act_comment": "Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "sertindole targets DRD3",
"source_label": "sertindole",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.59",
"act_comment": "Ability to displace [3H]spiperone (0.3 nM) from CHO cells of human Dopamine receptor D3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "sertindole targets DRD4",
"source_label": "sertindole",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Displacement of [3H]-YM-09151-2 (0.06 nM) from human Dopamine receptor D4 expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "sertindole targets HRH1",
"source_label": "sertindole",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.29",
"act_comment": "Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "sertindole targets HTR1A",
"source_label": "sertindole",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.48",
"act_comment": "Ability to displace [3H]5-CT (2.0 nM) from HeLa cells of human 5-hydroxytryptamine 1A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "sertindole targets HTR1B",
"source_label": "sertindole",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.25",
"act_comment": "Ability to displace [3H]5-CT (1.5 nM) from HeLa cells of human 5-hydroxytryptamine 1B receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "sertindole targets HTR1D",
"source_label": "sertindole",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "sertindole targets HTR1E",
"source_label": "sertindole",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "sertindole targets HTR1F",
"source_label": "sertindole",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "sertindole targets HTR2A",
"source_label": "sertindole",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.22",
"act_comment": "Binding affinity towards Serotonin 5-hydroxytryptamine 2A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "sertindole targets HTR2C",
"source_label": "sertindole",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "Displacement of [3H]prozosin from human cloned 5HT2C receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "sertindole targets HTR6",
"source_label": "sertindole",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "Displacement of [3H]5-LSD from human 5HT6 receptor expressed in human HeLa cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "sertindole targets HTR7",
"source_label": "sertindole",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.553",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60149",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "sertindole targets KCNH2",
"source_label": "sertindole",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.57",
"act_comment": "Inhibition of human cloned ERG expressed in CHO cells assessed as inhibition of potassium channel current by automated patch clamp assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68617",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "sertraline targets ADRA1A",
"source_label": "sertraline",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.863",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:68617",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "sertraline targets ADRA2A",
"source_label": "sertraline",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.965",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:68617",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "sertraline targets ADRA2B",
"source_label": "sertraline",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.082",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:68617",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "sertraline targets ADRA2C",
"source_label": "sertraline",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.187",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:68617",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "sertraline targets CHRM1",
"source_label": "sertraline",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.128",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:68617",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "sertraline targets CYP2C19",
"source_label": "sertraline",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:68617",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "sertraline targets HTR2A",
"source_label": "sertraline",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.106",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:68617",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "sertraline targets HTR2C",
"source_label": "sertraline",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.246",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:68617",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "sertraline targets SIGMAR1",
"source_label": "sertraline",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.24",
"act_comment": "Binding affinity to sigma 1 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68617",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "sertraline targets SLC6A2",
"source_label": "sertraline",
"target_label": "SLC6A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:68617",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "sertraline targets SLC6A3",
"source_label": "sertraline",
"target_label": "SLC6A3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:68617",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "sertraline targets SLC6A4",
"source_label": "sertraline",
"target_label": "SLC6A4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.54",
"act_comment": "Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter-hSERT",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5210",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "sibutramine targets SLC6A3",
"source_label": "sibutramine",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.026",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5210",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "sibutramine targets SLC6A4",
"source_label": "sibutramine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.526",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5212",
"relation": "IDG (Drug Target)",
"target": "134",
"properties": {
"id": "sildenafil targets ADORA1",
"source_label": "sildenafil",
"target_label": "ADORA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.06",
"act_comment": "DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5212",
"relation": "IDG (Drug Target)",
"target": "135",
"properties": {
"id": "sildenafil targets ADORA2A",
"source_label": "sildenafil",
"target_label": "ADORA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Displacement of [3H]ZM241385 from human AA2AR expressed in HEK293T cells after 2 hrs by liquid scintillation counter",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5212",
"relation": "IDG (Drug Target)",
"target": "8654",
"properties": {
"id": "sildenafil targets PDE5A",
"source_label": "sildenafil",
"target_label": "PDE5A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5212",
"relation": "IDG (Drug Target)",
"target": "5146",
"properties": {
"id": "sildenafil targets PDE6C",
"source_label": "sildenafil",
"target_label": "PDE6C",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.41",
"act_comment": "Inhibition of human recombinant PDE6C at 1 uM by [3H]cGMP based tritium scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5212",
"relation": "IDG (Drug Target)",
"target": "28234",
"properties": {
"id": "sildenafil targets SLCO1B3",
"source_label": "sildenafil",
"target_label": "SLCO1B3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:54454",
"relation": "IDG (Drug Target)",
"target": "3156",
"properties": {
"id": "simvastatin targets HMGCR",
"source_label": "simvastatin",
"target_label": "HMGCR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5282071",
"relation": "IDG (Drug Target)",
"target": "5243",
"properties": {
"id": "sirolimus targets ABCB1",
"source_label": "sirolimus",
"target_label": "ABCB1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5282071",
"relation": "IDG (Drug Target)",
"target": "1977",
"properties": {
"id": "sirolimus targets EIF4E",
"source_label": "sirolimus",
"target_label": "EIF4E",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "Binding affinity to purified elF4E",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5282071",
"relation": "IDG (Drug Target)",
"target": "2280",
"properties": {
"id": "sirolimus targets FKBP1A",
"source_label": "sirolimus",
"target_label": "FKBP1A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.96",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5282071",
"relation": "IDG (Drug Target)",
"target": "2281",
"properties": {
"id": "sirolimus targets FKBP1B",
"source_label": "sirolimus",
"target_label": "FKBP1B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5282071",
"relation": "IDG (Drug Target)",
"target": "2287",
"properties": {
"id": "sirolimus targets FKBP3",
"source_label": "sirolimus",
"target_label": "FKBP3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5282071",
"relation": "IDG (Drug Target)",
"target": "2289",
"properties": {
"id": "sirolimus targets FKBP5",
"source_label": "sirolimus",
"target_label": "FKBP5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "Binding affinity to human FKBP51 by competitive fluorescence polarization assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5282071",
"relation": "IDG (Drug Target)",
"target": "2475",
"properties": {
"id": "sirolimus targets MTOR",
"source_label": "sirolimus",
"target_label": "MTOR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.0",
"act_comment": "Inhibition of mTOR kinase expressed in human HEK293 cells by Western blot analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5282071",
"relation": "IDG (Drug Target)",
"target": "27250",
"properties": {
"id": "sirolimus targets PDCD4",
"source_label": "sirolimus",
"target_label": "PDCD4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Inhibition of TPA-induced degradation of Pdcd4 (amino acid 39-91) expressed in human HEK293 cells assessed as minimum compound concentration required for 50% recovery of Pdcd4-luciferase signal incubated for 8 hrs by luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5282071",
"relation": "IDG (Drug Target)",
"target": "9154",
"properties": {
"id": "sirolimus targets SLC28A1",
"source_label": "sirolimus",
"target_label": "SLC28A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.431",
"act_comment": "DRUGMATRIX: Sodium/nucleoside co-transporter radioligand binding (ligand: nitrobenzylthioinosine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4369359",
"relation": "IDG (Drug Target)",
"target": "1803",
"properties": {
"id": "sitagliptin targets DPP4",
"source_label": "sitagliptin",
"target_label": "DPP4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.774",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:222284",
"relation": "IDG (Drug Target)",
"target": "2147",
"properties": {
"id": "sitosterol targets F2",
"source_label": "sitosterol",
"target_label": "F2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Uncompetitive inhibition of human thrombin using T1637 as substrate by Michaelis-Menten plot analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:222284",
"relation": "IDG (Drug Target)",
"target": "4128",
"properties": {
"id": "sitosterol targets MAOA",
"source_label": "sitosterol",
"target_label": "MAOA",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.34",
"act_comment": "Competitive inhibition of human recombinant MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by Lineweaver-Burk plot analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:107706",
"relation": "IDG (Drug Target)",
"target": "1991",
"properties": {
"id": "sivelestat targets ELANE",
"source_label": "sivelestat",
"target_label": "ELANE",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Binding affinity against Elastase.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:107706",
"relation": "IDG (Drug Target)",
"target": "5657",
"properties": {
"id": "sivelestat targets PRTN3",
"source_label": "sivelestat",
"target_label": "PRTN3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:45934210",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "solifenacin targets CHRM1",
"source_label": "solifenacin",
"target_label": "CHRM1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:45934210",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "solifenacin targets CHRM2",
"source_label": "solifenacin",
"target_label": "CHRM2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:45934210",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "solifenacin targets CHRM3",
"source_label": "solifenacin",
"target_label": "CHRM3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.88",
"act_comment": "Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:45934210",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "solifenacin targets CHRM4",
"source_label": "solifenacin",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:45934210",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "solifenacin targets CHRM5",
"source_label": "solifenacin",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "sorafenib targets ABL1",
"source_label": "sorafenib",
"target_label": "ABL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Average Binding Constant for ABL1; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "369",
"properties": {
"id": "sorafenib targets ARAF",
"source_label": "sorafenib",
"target_label": "ARAF",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.15",
"act_comment": "Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter binding method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "9212",
"properties": {
"id": "sorafenib targets AURKB",
"source_label": "sorafenib",
"target_label": "AURKB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Binding constant for AURKB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "6795",
"properties": {
"id": "sorafenib targets AURKC",
"source_label": "sorafenib",
"target_label": "AURKC",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Binding constant for full-length AURKC",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "673",
"properties": {
"id": "sorafenib targets BRAF",
"source_label": "sorafenib",
"target_label": "BRAF",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.66",
"act_comment": "Inhibition of B-Raf",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "23097",
"properties": {
"id": "sorafenib targets CDK19",
"source_label": "sorafenib",
"target_label": "CDK19",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Binding constant for CDK11 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "1021",
"properties": {
"id": "sorafenib targets CDK6",
"source_label": "sorafenib",
"target_label": "CDK6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Inhibition of CDK6 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "1022",
"properties": {
"id": "sorafenib targets CDK7",
"source_label": "sorafenib",
"target_label": "CDK7",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Binding constant for full-length CDK7",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "1024",
"properties": {
"id": "sorafenib targets CDK8",
"source_label": "sorafenib",
"target_label": "CDK8",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "Binding constant for CDK8 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "8999",
"properties": {
"id": "sorafenib targets CDKL2",
"source_label": "sorafenib",
"target_label": "CDKL2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Binding affinity to CDKL2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "51265",
"properties": {
"id": "sorafenib targets CDKL3",
"source_label": "sorafenib",
"target_label": "CDKL3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.31",
"act_comment": "Binding affinity to CDKL3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "1436",
"properties": {
"id": "sorafenib targets CSF1R",
"source_label": "sorafenib",
"target_label": "CSF1R",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.55",
"act_comment": "Binding constant for CSF1R kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "1452",
"properties": {
"id": "sorafenib targets CSNK1A1",
"source_label": "sorafenib",
"target_label": "CSNK1A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Inhibition of recombinant CK1 by radioactive phosphotransfer assay in presence of 10 uM ATP",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "780",
"properties": {
"id": "sorafenib targets DDR1",
"source_label": "sorafenib",
"target_label": "DDR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.82",
"act_comment": "Binding constant for DDR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "4921",
"properties": {
"id": "sorafenib targets DDR2",
"source_label": "sorafenib",
"target_label": "DDR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.18",
"act_comment": "Binding constant for DDR2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "sorafenib targets EGFR",
"source_label": "sorafenib",
"target_label": "EGFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.53",
"act_comment": "Inhibition of EGFR (unknown origin) incubated for 1 hr assessed as luminescence changes using ATP by ADP-Glo Kinase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "2044",
"properties": {
"id": "sorafenib targets EPHA5",
"source_label": "sorafenib",
"target_label": "EPHA5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Average Binding Constant for EPHA5; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "285220",
"properties": {
"id": "sorafenib targets EPHA6",
"source_label": "sorafenib",
"target_label": "EPHA6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Average Binding Constant for EPHA6; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "2045",
"properties": {
"id": "sorafenib targets EPHA7",
"source_label": "sorafenib",
"target_label": "EPHA7",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Average Binding Constant for EPHA7; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "2046",
"properties": {
"id": "sorafenib targets EPHA8",
"source_label": "sorafenib",
"target_label": "EPHA8",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "Average Binding Constant for EPHA8; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "2051",
"properties": {
"id": "sorafenib targets EPHB6",
"source_label": "sorafenib",
"target_label": "EPHB6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding affinity to EPHB6",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "2053",
"properties": {
"id": "sorafenib targets EPHX2",
"source_label": "sorafenib",
"target_label": "EPHX2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "2321",
"properties": {
"id": "sorafenib targets FLT1",
"source_label": "sorafenib",
"target_label": "FLT1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.51",
"act_comment": "Binding constant for FLT1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "sorafenib targets FLT3",
"source_label": "sorafenib",
"target_label": "FLT3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.35",
"act_comment": "Binding constant for FLT3(K663Q) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "2324",
"properties": {
"id": "sorafenib targets FLT4",
"source_label": "sorafenib",
"target_label": "FLT4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "Average Binding Constant for FLT4; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "2444",
"properties": {
"id": "sorafenib targets FRK",
"source_label": "sorafenib",
"target_label": "FRK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Average Binding Constant for FRK; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "10114",
"properties": {
"id": "sorafenib targets HIPK3",
"source_label": "sorafenib",
"target_label": "HIPK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "Binding affinity to HIPK3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "147746",
"properties": {
"id": "sorafenib targets HIPK4",
"source_label": "sorafenib",
"target_label": "HIPK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.57",
"act_comment": "Binding affinity to HIPK4",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "sorafenib targets HTR2B",
"source_label": "sorafenib",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.25",
"act_comment": "Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "sorafenib targets HTR2C",
"source_label": "sorafenib",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Displacement of [3H]LSD from 5HT2C receptor after 1.5 hrs by scintillation counter",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "sorafenib targets KDR",
"source_label": "sorafenib",
"target_label": "KDR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.68",
"act_comment": "Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 60 mins by activity based 100 fold dilution assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "sorafenib targets KIT",
"source_label": "sorafenib",
"target_label": "KIT",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "Binding constant for KIT(V559D) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "5607",
"properties": {
"id": "sorafenib targets MAP2K5",
"source_label": "sorafenib",
"target_label": "MAP2K5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Binding constant for MEK5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "80122",
"properties": {
"id": "sorafenib targets MAP3K19",
"source_label": "sorafenib",
"target_label": "MAP3K19",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Binding affinity to YSK4",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "6885",
"properties": {
"id": "sorafenib targets MAP3K7",
"source_label": "sorafenib",
"target_label": "MAP3K7",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "Binding affinity to TAK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "5594",
"properties": {
"id": "sorafenib targets MAPK1",
"source_label": "sorafenib",
"target_label": "MAPK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "5600",
"properties": {
"id": "sorafenib targets MAPK11",
"source_label": "sorafenib",
"target_label": "MAPK11",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Average Binding Constant for p38-beta; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "1432",
"properties": {
"id": "sorafenib targets MAPK14",
"source_label": "sorafenib",
"target_label": "MAPK14",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "Average Binding Constant for p38-alpha; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "225689",
"properties": {
"id": "sorafenib targets MAPK15",
"source_label": "sorafenib",
"target_label": "MAPK15",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.34",
"act_comment": "Binding constant for ERK8 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "5595",
"properties": {
"id": "sorafenib targets MAPK3",
"source_label": "sorafenib",
"target_label": "MAPK3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.74",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "8569",
"properties": {
"id": "sorafenib targets MKNK1",
"source_label": "sorafenib",
"target_label": "MKNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Binding constant for full-length MKNK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "2872",
"properties": {
"id": "sorafenib targets MKNK2",
"source_label": "sorafenib",
"target_label": "MKNK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Binding constant for MKNK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "4593",
"properties": {
"id": "sorafenib targets MUSK",
"source_label": "sorafenib",
"target_label": "MUSK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Binding constant for MUSK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "51701",
"properties": {
"id": "sorafenib targets NLK",
"source_label": "sorafenib",
"target_label": "NLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Binding constant for full-length NLK",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "4916",
"properties": {
"id": "sorafenib targets NTRK3",
"source_label": "sorafenib",
"target_label": "NTRK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Binding constant for TRKC kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "5156",
"properties": {
"id": "sorafenib targets PDGFRA",
"source_label": "sorafenib",
"target_label": "PDGFRA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.21",
"act_comment": "Binding constant for PDGFRA kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "sorafenib targets PDGFRB",
"source_label": "sorafenib",
"target_label": "PDGFRB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.43",
"act_comment": "Binding constant for PDGFRB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "5894",
"properties": {
"id": "sorafenib targets RAF1",
"source_label": "sorafenib",
"target_label": "RAF1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "Inhibition of C-RAF",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "sorafenib targets RET",
"source_label": "sorafenib",
"target_label": "RET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.13",
"act_comment": "Binding constant for RET(M918T) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "9748",
"properties": {
"id": "sorafenib targets SLK",
"source_label": "sorafenib",
"target_label": "SLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for SLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "6714",
"properties": {
"id": "sorafenib targets SRC",
"source_label": "sorafenib",
"target_label": "SRC",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "Inhibition of recombinant c-Src by radioactive phosphotransfer assay in presence of 10 uM ATP",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "6793",
"properties": {
"id": "sorafenib targets STK10",
"source_label": "sorafenib",
"target_label": "STK10",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Average Binding Constant for STK10; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "57551",
"properties": {
"id": "sorafenib targets TAOK1",
"source_label": "sorafenib",
"target_label": "TAOK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.27",
"act_comment": "Binding affinity to TAO1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "9344",
"properties": {
"id": "sorafenib targets TAOK2",
"source_label": "sorafenib",
"target_label": "TAOK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.27",
"act_comment": "Binding constant for TAOK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "7075",
"properties": {
"id": "sorafenib targets TIE1",
"source_label": "sorafenib",
"target_label": "TIE1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.17",
"act_comment": "Binding constant for TIE1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "51086",
"properties": {
"id": "sorafenib targets TNNI3K",
"source_label": "sorafenib",
"target_label": "TNNI3K",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Binding constant for full-length TNNI3K",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216239",
"relation": "IDG (Drug Target)",
"target": "51776",
"properties": {
"id": "sorafenib targets MAP3K20",
"source_label": "sorafenib",
"target_label": "MAP3K20",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "Binding constant for ZAK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5253",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "sotalol targets ADRB1",
"source_label": "sotalol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5253",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "sotalol targets ADRB2",
"source_label": "sotalol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5265",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "spiperone targets ADRA1A",
"source_label": "spiperone",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "Binding constant measured against Alpha-1A adrenergic receptor in human prostate; ++:moderately active",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5265",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "spiperone targets ADRA1B",
"source_label": "spiperone",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5265",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "spiperone targets ADRA1D",
"source_label": "spiperone",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5265",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "spiperone targets DRD1",
"source_label": "spiperone",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.49",
"act_comment": "Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5265",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "spiperone targets DRD2",
"source_label": "spiperone",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.22",
"act_comment": "Binding affinity against dopamine receptor D2 by using [3H]spiperone as radioligand in caudate-putamen of monkey",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5265",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "spiperone targets DRD3",
"source_label": "spiperone",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.92",
"act_comment": "Displacement of [3H]Spiperone from human recombinant dopamine D3 receptor expressed in CHO cells after 2 hrs",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5265",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "spiperone targets DRD4",
"source_label": "spiperone",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "Displacement of [3H]Spiperone from human recombinant dopamine D4 receptor expressed in CHOK1 cells after 2 hrs",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5265",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "spiperone targets HRH1",
"source_label": "spiperone",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.322",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5265",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "spiperone targets HTR1A",
"source_label": "spiperone",
"target_label": "HTR1A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "Binding affinity to 5HT1A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5265",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "spiperone targets HTR1D",
"source_label": "spiperone",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5265",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "spiperone targets HTR1F",
"source_label": "spiperone",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5265",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "spiperone targets HTR2A",
"source_label": "spiperone",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.65",
"act_comment": "Displacement of [3H]Ketanserin from human 5HT2A receptor expressed in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5265",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "spiperone targets HTR2B",
"source_label": "spiperone",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5265",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "spiperone targets HTR7",
"source_label": "spiperone",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Binding affinity towards human 5-hydroxytryptamine 7 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5265",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "spiperone targets SIGMAR1",
"source_label": "spiperone",
"target_label": "SIGMAR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "The compound was tested for affinity towards sigma-3 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311447",
"relation": "IDG (Drug Target)",
"target": "1636",
"properties": {
"id": "spirapril targets ACE",
"source_label": "spirapril",
"target_label": "ACE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "Compound tested in vitro for inhibition of Angiotensin I converting enzyme",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5833",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "spironolactone targets AR",
"source_label": "spironolactone",
"target_label": "AR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "Binding affinity to human androgen receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5833",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "spironolactone targets NR3C1",
"source_label": "spironolactone",
"target_label": "NR3C1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.227",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5833",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "spironolactone targets NR3C2",
"source_label": "spironolactone",
"target_label": "NR3C2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.884",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5833",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "spironolactone targets PGR",
"source_label": "spironolactone",
"target_label": "PGR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.029",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:73707524",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "stanozolol targets CYP2C19",
"source_label": "stanozolol",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.319",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:73707524",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "stanozolol targets ESR1",
"source_label": "stanozolol",
"target_label": "ESR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.495",
"act_comment": "DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5702135",
"relation": "IDG (Drug Target)",
"target": "259292",
"properties": {
"id": "strychnine targets TAS2R46",
"source_label": "strychnine",
"target_label": "TAS2R46",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.367",
"act_comment": "calcium imaging in ransfected human embryonic kidney (HEK)-293T",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:41693",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "sufentanil targets OPRD1",
"source_label": "sufentanil",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.301",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:41693",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "sufentanil targets OPRK1",
"source_label": "sufentanil",
"target_label": "OPRK1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:41693",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "sufentanil targets OPRM1",
"source_label": "sufentanil",
"target_label": "OPRM1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.13",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5318",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "sulconazole targets ADRA2C",
"source_label": "sulconazole",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.144",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5318",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "sulconazole targets CHRM1",
"source_label": "sulconazole",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.053",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5318",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "sulconazole targets CHRM3",
"source_label": "sulconazole",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.142",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5318",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "sulconazole targets CHRM4",
"source_label": "sulconazole",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.258",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5318",
"relation": "IDG (Drug Target)",
"target": "1544",
"properties": {
"id": "sulconazole targets CYP1A2",
"source_label": "sulconazole",
"target_label": "CYP1A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.222",
"act_comment": "DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5318",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "sulconazole targets CYP2C19",
"source_label": "sulconazole",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5318",
"relation": "IDG (Drug Target)",
"target": "1559",
"properties": {
"id": "sulconazole targets CYP2C9",
"source_label": "sulconazole",
"target_label": "CYP2C9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.699",
"act_comment": "DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5318",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "sulconazole targets CYP2D6",
"source_label": "sulconazole",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.097",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5318",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "sulconazole targets CYP3A4",
"source_label": "sulconazole",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.155",
"act_comment": "DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5318",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "sulconazole targets SLC6A4",
"source_label": "sulconazole",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.125",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5318",
"relation": "IDG (Drug Target)",
"target": "6916",
"properties": {
"id": "sulconazole targets TBXAS1",
"source_label": "sulconazole",
"target_label": "TBXAS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.738",
"act_comment": "DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5215",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "sulfadiazine targets HTR2A",
"source_label": "sulfadiazine",
"target_label": "HTR2A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5323",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "sulfadimethoxine targets HTR6",
"source_label": "sulfadimethoxine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.206",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5324",
"relation": "IDG (Drug Target)",
"target": "2147",
"properties": {
"id": "sulfaguanidine targets F2",
"source_label": "sulfaguanidine",
"target_label": "F2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.02",
"act_comment": "Inhibitory activity against human thrombin (using Chromozym TH as the substrate)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5333",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "sulfanilamide targets CA1",
"source_label": "sulfanilamide",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5333",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "sulfanilamide targets CA12",
"source_label": "sulfanilamide",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.43",
"act_comment": "Inhibitory constant against catalytic domain of human carbonic anhydrase XII",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5333",
"relation": "IDG (Drug Target)",
"target": "377677",
"properties": {
"id": "sulfanilamide targets CA13",
"source_label": "sulfanilamide",
"target_label": "CA13",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.49",
"act_comment": "Inhibition of human recombinant CA13 by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5333",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "sulfanilamide targets CA2",
"source_label": "sulfanilamide",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Ki value against human carbonic anhydrase II",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5333",
"relation": "IDG (Drug Target)",
"target": "761",
"properties": {
"id": "sulfanilamide targets CA3",
"source_label": "sulfanilamide",
"target_label": "CA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Inhibition of human recombinant CA3 by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5333",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "sulfanilamide targets CA6",
"source_label": "sulfanilamide",
"target_label": "CA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "Inhibition of full length human recombinant CA VI",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5333",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "sulfanilamide targets CA7",
"source_label": "sulfanilamide",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "Ki value against human carbonic anhydrase VII",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5333",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "sulfanilamide targets CA9",
"source_label": "sulfanilamide",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Inhibition of catalytic domain of human recombinant CA IX",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5335",
"relation": "IDG (Drug Target)",
"target": "1559",
"properties": {
"id": "sulfaphenazole targets CYP2C9",
"source_label": "sulfaphenazole",
"target_label": "CYP2C9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.699",
"act_comment": "DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5342",
"relation": "IDG (Drug Target)",
"target": "93100",
"properties": {
"id": "sulfinpyrazone targets NAPRT",
"source_label": "sulfinpyrazone",
"target_label": "NAPRT",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "Inhibition of NAPRT (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5344",
"relation": "IDG (Drug Target)",
"target": "1909",
"properties": {
"id": "sulfafurazole targets EDNRA",
"source_label": "sulfafurazole",
"target_label": "EDNRA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Inhibitory concentration against Endothelin A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:31765",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "sulforidazine targets DRD2",
"source_label": "sulforidazine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.611",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:31765",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "sulforidazine targets DRD3",
"source_label": "sulforidazine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.155",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:1548887",
"relation": "IDG (Drug Target)",
"target": "231",
"properties": {
"id": "sulindac targets AKR1B1",
"source_label": "sulindac",
"target_label": "AKR1B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.43",
"act_comment": "Inhibition of Homo sapiens (human) aldose reductase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1548887",
"relation": "IDG (Drug Target)",
"target": "727",
"properties": {
"id": "sulindac targets C5",
"source_label": "sulindac",
"target_label": "C5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Binding affinity to human C5a assessed as dissociation constant after 1 hr by circular dichroism analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1548887",
"relation": "IDG (Drug Target)",
"target": "2741",
"properties": {
"id": "sulindac targets GLRA1",
"source_label": "sulindac",
"target_label": "GLRA1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:657255",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "suloctidil targets ADRA2A",
"source_label": "suloctidil",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:657255",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "suloctidil targets ADRA2C",
"source_label": "suloctidil",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:657255",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "suloctidil targets CHRM3",
"source_label": "suloctidil",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.009",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:657255",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "suloctidil targets CHRM4",
"source_label": "suloctidil",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.196",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:657255",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "suloctidil targets DRD3",
"source_label": "suloctidil",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.146",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:657255",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "suloctidil targets EGFR",
"source_label": "suloctidil",
"target_label": "EGFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr))",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:657255",
"relation": "IDG (Drug Target)",
"target": "2534",
"properties": {
"id": "suloctidil targets FYN",
"source_label": "suloctidil",
"target_label": "FYN",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.141",
"act_comment": "DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr))",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:657255",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "suloctidil targets HRH2",
"source_label": "suloctidil",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.053",
"act_comment": "DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:657255",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "suloctidil targets HTR1A",
"source_label": "suloctidil",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.508",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:657255",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "suloctidil targets HTR2B",
"source_label": "suloctidil",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.224",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:657255",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "suloctidil targets SIGMAR1",
"source_label": "suloctidil",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.307",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:657255",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "suloctidil targets SLC6A4",
"source_label": "suloctidil",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.177",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4018928",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "sulpiride targets ADRA2A",
"source_label": "sulpiride",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.121",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4018928",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "sulpiride targets CA12",
"source_label": "sulpiride",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.41",
"act_comment": "Ki value against human carbonic anhydrase XII (hCA XII)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4018928",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "sulpiride targets CA2",
"source_label": "sulpiride",
"target_label": "CA2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.398",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4018928",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "sulpiride targets CA5A",
"source_label": "sulpiride",
"target_label": "CA5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.76",
"act_comment": "Inhibitory activity against human recombinant mitochondrial isozyme CA VA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4018928",
"relation": "IDG (Drug Target)",
"target": "11238",
"properties": {
"id": "sulpiride targets CA5B",
"source_label": "sulpiride",
"target_label": "CA5B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.74",
"act_comment": "Inhibitory activity against human recombinant mitochondrial isozyme CA VB",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4018928",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "sulpiride targets CA6",
"source_label": "sulpiride",
"target_label": "CA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "Inhibition of full length human recombinant CA VI",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4018928",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "sulpiride targets CA7",
"source_label": "sulpiride",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.44",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4018928",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "sulpiride targets CA9",
"source_label": "sulpiride",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.51",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 9 by stopped-flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4018928",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "sulpiride targets DRD2",
"source_label": "sulpiride",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.12",
"act_comment": "Antagonist activity at dopamine D2 receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4018928",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "sulpiride targets DRD3",
"source_label": "sulpiride",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5312153",
"relation": "IDG (Drug Target)",
"target": "5731",
"properties": {
"id": "sulprostone targets PTGER1",
"source_label": "sulprostone",
"target_label": "PTGER1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5312153",
"relation": "IDG (Drug Target)",
"target": "5733",
"properties": {
"id": "sulprostone targets PTGER3",
"source_label": "sulprostone",
"target_label": "PTGER3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.46",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5312153",
"relation": "IDG (Drug Target)",
"target": "5737",
"properties": {
"id": "sulprostone targets PTGFR",
"source_label": "sulprostone",
"target_label": "PTGFR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5356",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "sultiame targets CA1",
"source_label": "sultiame",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.43",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5356",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "sultiame targets CA2",
"source_label": "sultiame",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5356",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "sultiame targets CA6",
"source_label": "sultiame",
"target_label": "CA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.87",
"act_comment": "Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5356",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "sultiame targets CA9",
"source_label": "sultiame",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.37",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5357",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "sultopride targets DRD2",
"source_label": "sultopride",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.571",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5357",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "sultopride targets DRD3",
"source_label": "sultopride",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.42",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5358",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "sumatriptan targets HTR1A",
"source_label": "sumatriptan",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5358",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "sumatriptan targets HTR1B",
"source_label": "sumatriptan",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.26",
"act_comment": "Binding affinity was measured on 5-hydroxytryptamine 1D receptor beta in CHO cells transfected with human 5-HT1D beta gene labeled with [3H]5-HT",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5358",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "sumatriptan targets HTR1D",
"source_label": "sumatriptan",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.92",
"act_comment": "Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5358",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "sumatriptan targets HTR1F",
"source_label": "sumatriptan",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.59",
"act_comment": "Binding affinity towards human 5-hydroxytryptamine 1F receptor was determined",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5358",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "sumatriptan targets HTR2A",
"source_label": "sumatriptan",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 2A receptor from cloned Human membranes",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5358",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "sumatriptan targets HTR2C",
"source_label": "sumatriptan",
"target_label": "HTR2C",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.14",
"act_comment": "Compound was evaluated for the affinity at 5-hydroxytryptamine 2C receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5358",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "sumatriptan targets HTR3A",
"source_label": "sumatriptan",
"target_label": "HTR3A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.03",
"act_comment": "Compound was evaluated for the affinity at 5-hydroxytryptamine 3 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5358",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "sumatriptan targets HTR5A",
"source_label": "sumatriptan",
"target_label": "HTR5A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5358",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "sumatriptan targets HTR7",
"source_label": "sumatriptan",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "22848",
"properties": {
"id": "sunitinib targets AAK1",
"source_label": "sunitinib",
"target_label": "AAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Binding constant for AAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "sunitinib targets ABL1",
"source_label": "sunitinib",
"target_label": "ABL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.26",
"act_comment": "Binding constant for ABL1(T315I)-phosphorylated kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "27",
"properties": {
"id": "sunitinib targets ABL2",
"source_label": "sunitinib",
"target_label": "ABL2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for ABL2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "238",
"properties": {
"id": "sunitinib targets ALK",
"source_label": "sunitinib",
"target_label": "ALK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Binding constant for ALK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "255239",
"properties": {
"id": "sunitinib targets ANKK1",
"source_label": "sunitinib",
"target_label": "ANKK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "Binding constant for ANKK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "9212",
"properties": {
"id": "sunitinib targets AURKB",
"source_label": "sunitinib",
"target_label": "AURKB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Binding constant for AURKB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "6795",
"properties": {
"id": "sunitinib targets AURKC",
"source_label": "sunitinib",
"target_label": "AURKC",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Binding constant for full-length AURKC",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "558",
"properties": {
"id": "sunitinib targets AXL",
"source_label": "sunitinib",
"target_label": "AXL",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "Binding constant for AXL kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "640",
"properties": {
"id": "sunitinib targets BLK",
"source_label": "sunitinib",
"target_label": "BLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.19",
"act_comment": "Binding constant for BLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "55589",
"properties": {
"id": "sunitinib targets BMP2K",
"source_label": "sunitinib",
"target_label": "BMP2K",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.26",
"act_comment": "Binding constant for BIKE kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "659",
"properties": {
"id": "sunitinib targets BMPR2",
"source_label": "sunitinib",
"target_label": "BMPR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Binding constant for BMPR2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "8536",
"properties": {
"id": "sunitinib targets CAMK1",
"source_label": "sunitinib",
"target_label": "CAMK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Binding constant for full-length CAMK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "57118",
"properties": {
"id": "sunitinib targets CAMK1D",
"source_label": "sunitinib",
"target_label": "CAMK1D",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "Binding constant for CAMK1D kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "57172",
"properties": {
"id": "sunitinib targets CAMK1G",
"source_label": "sunitinib",
"target_label": "CAMK1G",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Binding constant for CAMK1G kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "815",
"properties": {
"id": "sunitinib targets CAMK2A",
"source_label": "sunitinib",
"target_label": "CAMK2A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "Binding constant for CAMK2A kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "817",
"properties": {
"id": "sunitinib targets CAMK2D",
"source_label": "sunitinib",
"target_label": "CAMK2D",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Binding constant for CAMK2D kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "818",
"properties": {
"id": "sunitinib targets CAMK2G",
"source_label": "sunitinib",
"target_label": "CAMK2G",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Binding affinity to CAMK1G",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "814",
"properties": {
"id": "sunitinib targets CAMK4",
"source_label": "sunitinib",
"target_label": "CAMK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Binding constant for CAMK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "84254",
"properties": {
"id": "sunitinib targets CAMKK1",
"source_label": "sunitinib",
"target_label": "CAMKK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Binding constant for CAMKK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "5218",
"properties": {
"id": "sunitinib targets CDK14",
"source_label": "sunitinib",
"target_label": "CDK14",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Binding constant for full-length PFTK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "5127",
"properties": {
"id": "sunitinib targets CDK16",
"source_label": "sunitinib",
"target_label": "CDK16",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Average Binding Constant for PCTK1; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "1022",
"properties": {
"id": "sunitinib targets CDK7",
"source_label": "sunitinib",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "1111",
"properties": {
"id": "sunitinib targets CHEK1",
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"act_comment": "Binding constant for CHEK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "11200",
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"id": "sunitinib targets CHEK2",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "1147",
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"id": "sunitinib targets CHUK",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "1195",
"properties": {
"id": "sunitinib targets CLK1",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "1196",
"properties": {
"id": "sunitinib targets CLK2",
"source_label": "sunitinib",
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"act_value": "7.7",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "57396",
"properties": {
"id": "sunitinib targets CLK4",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "1436",
"properties": {
"id": "sunitinib targets CSF1R",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "1452",
"properties": {
"id": "sunitinib targets CSNK1A1",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "122011",
"properties": {
"id": "sunitinib targets CSNK1A1L",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "1453",
"properties": {
"id": "sunitinib targets CSNK1D",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "1454",
"properties": {
"id": "sunitinib targets CSNK1E",
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"act_relation": "=",
"act_value": "7.89",
"act_comment": "Binding constant for full-length CSNK1E",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "53944",
"properties": {
"id": "sunitinib targets CSNK1G1",
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"act_comment": "Binding constant for CSNK1G1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "1455",
"properties": {
"id": "sunitinib targets CSNK1G2",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "1456",
"properties": {
"id": "sunitinib targets CSNK1G3",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "1457",
"properties": {
"id": "sunitinib targets CSNK2A1",
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"act_relation": "=",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "1459",
"properties": {
"id": "sunitinib targets CSNK2A2",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "1612",
"properties": {
"id": "sunitinib targets DAPK1",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "23604",
"properties": {
"id": "sunitinib targets DAPK2",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "1613",
"properties": {
"id": "sunitinib targets DAPK3",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "9201",
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"id": "sunitinib targets DCLK1",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "85443",
"properties": {
"id": "sunitinib targets DCLK3",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "8788",
"properties": {
"id": "sunitinib targets DLK1",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "1859",
"properties": {
"id": "sunitinib targets DYRK1A",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "8445",
"properties": {
"id": "sunitinib targets DYRK2",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "sunitinib targets EGFR",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "5610",
"properties": {
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "440275",
"properties": {
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "285220",
"properties": {
"id": "sunitinib targets EPHA6",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "2047",
"properties": {
"id": "sunitinib targets EPHB1",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "2051",
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"id": "sunitinib targets EPHB6",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "2081",
"properties": {
"id": "sunitinib targets ERN1",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "2242",
"properties": {
"id": "sunitinib targets FES",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "2260",
"properties": {
"id": "sunitinib targets FGFR1",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "2263",
"properties": {
"id": "sunitinib targets FGFR2",
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"act_value": "6.28",
"act_comment": "Average Binding Constant for FGFR2; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
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"properties": {
"id": "sunitinib targets FGFR3",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "2268",
"properties": {
"id": "sunitinib targets FGR",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "2321",
"properties": {
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"act_comment": "inhibition at physiological ATP concentration",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
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"properties": {
"id": "sunitinib targets FLT3",
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"act_type": "Kd",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "2324",
"properties": {
"id": "sunitinib targets FLT4",
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"act_type": "Ki",
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"act_value": "7.77",
"act_comment": "Binding affinity to VEGFR3 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "2444",
"properties": {
"id": "sunitinib targets FRK",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "2534",
"properties": {
"id": "sunitinib targets FYN",
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"act_value": "6.28",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "2580",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "6011",
"properties": {
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "2868",
"properties": {
"id": "sunitinib targets GRK4",
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"act_relation": "=",
"act_value": "6.85",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "131890",
"properties": {
"id": "sunitinib targets GRK7",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "3055",
"properties": {
"id": "sunitinib targets HCK",
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"act_relation": "=",
"act_value": "6.06",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "204851",
"properties": {
"id": "sunitinib targets HIPK1",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "28996",
"properties": {
"id": "sunitinib targets HIPK2",
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"act_value": "7.51",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "10114",
"properties": {
"id": "sunitinib targets HIPK3",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "7.39",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "147746",
"properties": {
"id": "sunitinib targets HIPK4",
"source_label": "sunitinib",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "Binding affinity to HIPK4",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "30811",
"properties": {
"id": "sunitinib targets HUNK",
"source_label": "sunitinib",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.3",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "22858",
"properties": {
"id": "sunitinib targets CILK1",
"source_label": "sunitinib",
"target_label": "CILK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Binding affinity to ICK",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "9641",
"properties": {
"id": "sunitinib targets IKBKE",
"source_label": "sunitinib",
"target_label": "IKBKE",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Binding constant for full-length IKK-epsilon",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "3643",
"properties": {
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
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"id": "sunitinib targets IRAK1",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "11213",
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"id": "sunitinib targets IRAK3",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "51135",
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"id": "sunitinib targets IRAK4",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "3702",
"properties": {
"id": "sunitinib targets ITK",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
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"id": "sunitinib targets JAK2",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "3757",
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}
},
{
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"relation": "IDG (Drug Target)",
"target": "3791",
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"id": "sunitinib targets KDR",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "sunitinib targets KIT",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "9113",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
"target": "6416",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
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}
},
{
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}
},
{
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "10461",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "4593",
"properties": {
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "4638",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "85366",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "91807",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "340156",
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"act_comment": "Binding constant for SgK085 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
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"act_value": "6.3",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "167359",
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"id": "sunitinib targets NIM1K",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "4914",
"properties": {
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"act_value": "7.0",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "4915",
"properties": {
"id": "sunitinib targets NTRK2",
"source_label": "sunitinib",
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"act_relation": "=",
"act_value": "6.23",
"act_comment": "Binding constant for TRKB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "9891",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "7.32",
"act_comment": "Binding constant for ARK5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "81788",
"properties": {
"id": "sunitinib targets NUAK2",
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"act_value": "6.82",
"act_comment": "Binding constant for SNARK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "9943",
"properties": {
"id": "sunitinib targets OXSR1",
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"act_value": "6.28",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "5063",
"properties": {
"id": "sunitinib targets PAK3",
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"act_value": "7.8",
"act_comment": "Binding constant for full-length PAK3",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "57144",
"properties": {
"id": "sunitinib targets PAK5",
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"act_value": "6.19",
"act_comment": "Binding constant for PAK7/PAK5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "5156",
"properties": {
"id": "sunitinib targets PDGFRA",
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"act_type": "IC50",
"act_relation": "=",
"act_value": "6.959",
"act_comment": "inhibition at physiological ATP concentration",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "sunitinib targets PDGFRB",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "10.12",
"act_comment": "Binding constant for PDGFRB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "5260",
"properties": {
"id": "sunitinib targets PHKG1",
"source_label": "sunitinib",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "8.26",
"act_comment": "Binding constant for full-length PHKG1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "5261",
"properties": {
"id": "sunitinib targets PHKG2",
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"act_value": "8.23",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "8396",
"properties": {
"id": "sunitinib targets PIP4K2B",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "5585",
"properties": {
"id": "sunitinib targets PKN1",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "10733",
"properties": {
"id": "sunitinib targets PLK4",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "5562",
"properties": {
"id": "sunitinib targets PRKAA1",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "5563",
"properties": {
"id": "sunitinib targets PRKAA2",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "5587",
"properties": {
"id": "sunitinib targets PRKD1",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "25865",
"properties": {
"id": "sunitinib targets PRKD2",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "23683",
"properties": {
"id": "sunitinib targets PRKD3",
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"act_value": "6.55",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "9128",
"properties": {
"id": "sunitinib targets PRPF4",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "8899",
"properties": {
"id": "sunitinib targets PRPF4B",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "5747",
"properties": {
"id": "sunitinib targets PTK2",
"source_label": "sunitinib",
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"act_value": "6.36",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "2185",
"properties": {
"id": "sunitinib targets PTK2B",
"source_label": "sunitinib",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "sunitinib targets RET",
"source_label": "sunitinib",
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"act_type": "IC50",
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"act_value": "8.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "83732",
"properties": {
"id": "sunitinib targets RIOK1",
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"act_comment": "Binding constant for full-length RIOK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "55781",
"properties": {
"id": "sunitinib targets RIOK2",
"source_label": "sunitinib",
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"act_relation": "=",
"act_value": "7.31",
"act_comment": "Binding affinity to RIOK2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "8737",
"properties": {
"id": "sunitinib targets RIPK1",
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"act_value": "6.43",
"act_comment": "Binding constant for RIPK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "6093",
"properties": {
"id": "sunitinib targets ROCK1",
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"act_value": "6.34",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "9475",
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"id": "sunitinib targets ROCK2",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "6195",
"properties": {
"id": "sunitinib targets RPS6KA1",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "6196",
"properties": {
"id": "sunitinib targets RPS6KA2",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "6197",
"properties": {
"id": "sunitinib targets RPS6KA3",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "8986",
"properties": {
"id": "sunitinib targets RPS6KA4",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "9252",
"properties": {
"id": "sunitinib targets RPS6KA5",
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"act_comment": "Binding affinity to RPS6KA2(Kin.Dom.1-N-terminal)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "6198",
"properties": {
"id": "sunitinib targets RPS6KB1",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "388228",
"properties": {
"id": "sunitinib targets SBK1",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "23678",
"properties": {
"id": "sunitinib targets SGK3",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "23235",
"properties": {
"id": "sunitinib targets SIK2",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "9748",
"properties": {
"id": "sunitinib targets SLK",
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"act_relation": "=",
"act_value": "7.25",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "54861",
"properties": {
"id": "sunitinib targets SNRK",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Binding constant for SNRK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "6732",
"properties": {
"id": "sunitinib targets SRPK1",
"source_label": "sunitinib",
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"act_relation": "=",
"act_value": "6.6",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "6733",
"properties": {
"id": "sunitinib targets SRPK2",
"source_label": "sunitinib",
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"act_relation": "=",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "26576",
"properties": {
"id": "sunitinib targets SRPK3",
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"act_relation": "=",
"act_value": "7.23",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "6793",
"properties": {
"id": "sunitinib targets STK10",
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"act_comment": "Binding constant for LOK kinase domain",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "6794",
"properties": {
"id": "sunitinib targets STK11",
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"act_relation": "=",
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"act_comment": "Binding constant for full-length LKB1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "8576",
"properties": {
"id": "sunitinib targets STK16",
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}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "9263",
"properties": {
"id": "sunitinib targets STK17A",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "Binding constant for DRAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "9262",
"properties": {
"id": "sunitinib targets STK17B",
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"act_type": "Kd",
"act_relation": "=",
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"act_comment": "Binding constant for full-length DRAK2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "8428",
"properties": {
"id": "sunitinib targets STK24",
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"act_relation": "=",
"act_value": "7.2",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "10494",
"properties": {
"id": "sunitinib targets STK25",
"source_label": "sunitinib",
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"act_relation": "=",
"act_value": "6.54",
"act_comment": "Binding constant for YSK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "51765",
"properties": {
"id": "sunitinib targets STK26",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "Binding constant for full-length MST4",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "6788",
"properties": {
"id": "sunitinib targets STK3",
"source_label": "sunitinib",
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"act_relation": "=",
"act_value": "7.25",
"act_comment": "Binding constant for MST2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "65975",
"properties": {
"id": "sunitinib targets STK33",
"source_label": "sunitinib",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "7.77",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "11329",
"properties": {
"id": "sunitinib targets STK38",
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"target_label": "STK38",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "Binding affinity to NDR1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "23012",
"properties": {
"id": "sunitinib targets STK38L",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Binding constant for NDR2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "27347",
"properties": {
"id": "sunitinib targets STK39",
"source_label": "sunitinib",
"target_label": "STK39",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Binding affinity to STK39",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "6789",
"properties": {
"id": "sunitinib targets STK4",
"source_label": "sunitinib",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "Binding constant for full-length MST1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "57551",
"properties": {
"id": "sunitinib targets TAOK1",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Binding affinity to TAOK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "51347",
"properties": {
"id": "sunitinib targets TAOK3",
"source_label": "sunitinib",
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"act_type": "Kd",
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"act_value": "6.68",
"act_comment": "Binding affinity to TAOK3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "29110",
"properties": {
"id": "sunitinib targets TBK1",
"source_label": "sunitinib",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Binding affinity to TBK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "9874",
"properties": {
"id": "sunitinib targets TLK1",
"source_label": "sunitinib",
"target_label": "TLK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "Binding constant for TLK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "11011",
"properties": {
"id": "sunitinib targets TLK2",
"source_label": "sunitinib",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Binding constant for TLK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "23043",
"properties": {
"id": "sunitinib targets TNIK",
"source_label": "sunitinib",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "Average Binding Constant for TNIK; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "8711",
"properties": {
"id": "sunitinib targets TNK1",
"source_label": "sunitinib",
"target_label": "TNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Binding constant for full-length TNK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "7272",
"properties": {
"id": "sunitinib targets TTK",
"source_label": "sunitinib",
"target_label": "TTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "Binding constant for TTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "7297",
"properties": {
"id": "sunitinib targets TYK2",
"source_label": "sunitinib",
"target_label": "TYK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Binding affinity to TYK2(JH2domain-pseudokinase)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "7301",
"properties": {
"id": "sunitinib targets TYRO3",
"source_label": "sunitinib",
"target_label": "TYRO3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.31",
"act_comment": "Binding constant for TYRO3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "8408",
"properties": {
"id": "sunitinib targets ULK1",
"source_label": "sunitinib",
"target_label": "ULK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.64",
"act_comment": "Binding affinity to ULK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "9706",
"properties": {
"id": "sunitinib targets ULK2",
"source_label": "sunitinib",
"target_label": "ULK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Binding affinity to ULK2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "25989",
"properties": {
"id": "sunitinib targets ULK3",
"source_label": "sunitinib",
"target_label": "ULK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.38",
"act_comment": "Binding affinity to ULK3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5329102",
"relation": "IDG (Drug Target)",
"target": "7525",
"properties": {
"id": "sunitinib targets YES1",
"source_label": "sunitinib",
"target_label": "YES1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Binding constant for YES kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16158474",
"relation": "IDG (Drug Target)",
"target": "6344",
"properties": {
"id": "secretin human targets SCTR",
"source_label": "secretin human",
"target_label": "SCTR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:1935",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "tacrine targets ACHE",
"source_label": "tacrine",
"target_label": "ACHE",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.14",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:1935",
"relation": "IDG (Drug Target)",
"target": "351",
"properties": {
"id": "tacrine targets APP",
"source_label": "tacrine",
"target_label": "APP",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.91",
"act_comment": "Inhibition of self-mediated amyloid beta (1 to 42) (unknown origin) aggregation after 24 hrs by thioflavin T fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1935",
"relation": "IDG (Drug Target)",
"target": "590",
"properties": {
"id": "tacrine targets BCHE",
"source_label": "tacrine",
"target_label": "BCHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.301",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:1935",
"relation": "IDG (Drug Target)",
"target": "1145",
"properties": {
"id": "tacrine targets CHRNE",
"source_label": "tacrine",
"target_label": "CHRNE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.36",
"act_comment": "Inhibition of acetylcholinesterase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1935",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "tacrine targets CYP2D6",
"source_label": "tacrine",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.523",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1935",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "tacrine targets SLC6A2",
"source_label": "tacrine",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6473866",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "tacrolimus targets CYP3A4",
"source_label": "tacrolimus",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6473866",
"relation": "IDG (Drug Target)",
"target": "60681",
"properties": {
"id": "tacrolimus targets FKBP10",
"source_label": "tacrolimus",
"target_label": "FKBP10",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.02",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6473866",
"relation": "IDG (Drug Target)",
"target": "2280",
"properties": {
"id": "tacrolimus targets FKBP1A",
"source_label": "tacrolimus",
"target_label": "FKBP1A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.398",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6473866",
"relation": "IDG (Drug Target)",
"target": "2281",
"properties": {
"id": "tacrolimus targets FKBP1B",
"source_label": "tacrolimus",
"target_label": "FKBP1B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6473866",
"relation": "IDG (Drug Target)",
"target": "2289",
"properties": {
"id": "tacrolimus targets FKBP5",
"source_label": "tacrolimus",
"target_label": "FKBP5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "Binding affinity to human FKBP51 by competitive fluorescence polarization assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6473866",
"relation": "IDG (Drug Target)",
"target": "3458",
"properties": {
"id": "tacrolimus targets IFNG",
"source_label": "tacrolimus",
"target_label": "IFNG",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.22",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6473866",
"relation": "IDG (Drug Target)",
"target": "3558",
"properties": {
"id": "tacrolimus targets IL2",
"source_label": "tacrolimus",
"target_label": "IL2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.72",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6473866",
"relation": "IDG (Drug Target)",
"target": "3567",
"properties": {
"id": "tacrolimus targets IL5",
"source_label": "tacrolimus",
"target_label": "IL5",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.22",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6473866",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "tacrolimus targets KCNH2",
"source_label": "tacrolimus",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6473866",
"relation": "IDG (Drug Target)",
"target": "2475",
"properties": {
"id": "tacrolimus targets MTOR",
"source_label": "tacrolimus",
"target_label": "MTOR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.02",
"act_comment": "Inhibitory activity against macrophilin (FKBP-12)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6473866",
"relation": "IDG (Drug Target)",
"target": "5530",
"properties": {
"id": "tacrolimus targets PPP3CA",
"source_label": "tacrolimus",
"target_label": "PPP3CA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Binding affinity to protein phosphatase, calcineurin (CN) was determined",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6473866",
"relation": "IDG (Drug Target)",
"target": "5533",
"properties": {
"id": "tacrolimus targets PPP3CC",
"source_label": "tacrolimus",
"target_label": "PPP3CC",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.456",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6473866",
"relation": "IDG (Drug Target)",
"target": "23450",
"properties": {
"id": "tacrolimus targets SF3B3",
"source_label": "tacrolimus",
"target_label": "SF3B3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Inhibition of SAP130 mediated cell growth in human WiDr cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:110635",
"relation": "IDG (Drug Target)",
"target": "50940",
"properties": {
"id": "tadalafil targets PDE11A",
"source_label": "tadalafil",
"target_label": "PDE11A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.48",
"act_comment": "Inhibition of human phosphodiesterase 11",
"act_source": "CHEMBL"
}
},
{
"source": "CID:110635",
"relation": "IDG (Drug Target)",
"target": "8654",
"properties": {
"id": "tadalafil targets PDE5A",
"source_label": "tadalafil",
"target_label": "PDE5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Inhibition of human phosphodiesterase 5",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68770",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "talinolol targets ADRB1",
"source_label": "talinolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding affinity to beta1 adrenergic receptor (unknown origin) by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68770",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "talinolol targets ADRB2",
"source_label": "talinolol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Binding affinity to beta2 adrenergic receptor (unknown origin) by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5374",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "talipexole targets ADRA2A",
"source_label": "talipexole",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.915",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5374",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "talipexole targets ADRA2B",
"source_label": "talipexole",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.69",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5374",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "talipexole targets ADRA2C",
"source_label": "talipexole",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.695",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5374",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "talipexole targets DRD2",
"source_label": "talipexole",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.309",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5374",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "talipexole targets DRD3",
"source_label": "talipexole",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.481",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5374",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "talipexole targets DRD4",
"source_label": "talipexole",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:122173803",
"relation": "IDG (Drug Target)",
"target": "7201",
"properties": {
"id": "taltirelin targets TRHR",
"source_label": "taltirelin",
"target_label": "TRHR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:449459",
"relation": "IDG (Drug Target)",
"target": "5243",
"properties": {
"id": "tamoxifen targets ABCB1",
"source_label": "tamoxifen",
"target_label": "ABCB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:449459",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "tamoxifen targets ADRA2A",
"source_label": "tamoxifen",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.139",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:449459",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "tamoxifen targets CHRM1",
"source_label": "tamoxifen",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.167",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:449459",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "tamoxifen targets CHRM3",
"source_label": "tamoxifen",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.201",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:449459",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "tamoxifen targets CHRM4",
"source_label": "tamoxifen",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.173",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:449459",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "tamoxifen targets DRD3",
"source_label": "tamoxifen",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.439",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:449459",
"relation": "IDG (Drug Target)",
"target": "10682",
"properties": {
"id": "tamoxifen targets EBP",
"source_label": "tamoxifen",
"target_label": "EBP",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.301",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:449459",
"relation": "IDG (Drug Target)",
"target": "84650",
"properties": {
"id": "tamoxifen targets EBPL",
"source_label": "tamoxifen",
"target_label": "EBPL",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.55",
"act_comment": "Binding affinity to emopamil binding protein (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:449459",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "tamoxifen targets ESR1",
"source_label": "tamoxifen",
"target_label": "ESR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.51",
"act_comment": "Displacement of [2,4,6,7-3H]estradiol from human ERalpha expressed in HeLa cells after 18 hrs by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:449459",
"relation": "IDG (Drug Target)",
"target": "2101",
"properties": {
"id": "tamoxifen targets ESRRA",
"source_label": "tamoxifen",
"target_label": "ESRRA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Antagonist activity at ERalpha receptor in human MCF7 cells assessed as inhibition of cell growth after 6 days by crystal violet staining method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:449459",
"relation": "IDG (Drug Target)",
"target": "2104",
"properties": {
"id": "tamoxifen targets ESRRG",
"source_label": "tamoxifen",
"target_label": "ESRRG",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:449459",
"relation": "IDG (Drug Target)",
"target": "2852",
"properties": {
"id": "tamoxifen targets GPER1",
"source_label": "tamoxifen",
"target_label": "GPER1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:449459",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "tamoxifen targets HTR2C",
"source_label": "tamoxifen",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.618",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:449459",
"relation": "IDG (Drug Target)",
"target": "8856",
"properties": {
"id": "tamoxifen targets NR1I2",
"source_label": "tamoxifen",
"target_label": "NR1I2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.456",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:449459",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "tamoxifen targets PGR",
"source_label": "tamoxifen",
"target_label": "PGR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:449459",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "tamoxifen targets SIGMAR1",
"source_label": "tamoxifen",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:449459",
"relation": "IDG (Drug Target)",
"target": "6916",
"properties": {
"id": "tamoxifen targets TBXAS1",
"source_label": "tamoxifen",
"target_label": "TBXAS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.038",
"act_comment": "DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:129211",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "tamsulosin targets ADRA1A",
"source_label": "tamsulosin",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.54",
"act_comment": "Binding affinity against human adrenergic receptor subtype Alpha-1A adrenergic receptor using [3H]prazosin as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:129211",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "tamsulosin targets ADRA1B",
"source_label": "tamsulosin",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.21",
"act_comment": "Binding affinity against human adrenergic receptor subtype Alpha-1B adrenergic receptor using [3H]prazosin as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:129211",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "tamsulosin targets ADRA1D",
"source_label": "tamsulosin",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.24",
"act_comment": "Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:129211",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "tamsulosin targets ADRA2A",
"source_label": "tamsulosin",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.87",
"act_comment": "Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:129211",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "tamsulosin targets ADRA2C",
"source_label": "tamsulosin",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "Binding affinity against human Alpha-2C adrenergic receptor using [3H]rauwolscine as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:129211",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "tamsulosin targets DRD2",
"source_label": "tamsulosin",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Binding affinity towards recombinant human Dopamine receptor D2L was determined using [3H]spiperone as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:129211",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "tamsulosin targets DRD3",
"source_label": "tamsulosin",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.55",
"act_comment": "Binding affinity towards recombinant human Dopamine receptor D3 was determined using [3H]spiperone as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:129211",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "tamsulosin targets HTR1A",
"source_label": "tamsulosin",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "Binding affinity towards recombinant human Compound at 1 uM was tested for the inhibition of radioligand [3H]8-OH-DPAT binding to recombinant human 5-hydroxytryptamine 1A receptor was determined using [3H]8-OH-DPAT as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:129211",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "tamsulosin targets HTR7",
"source_label": "tamsulosin",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.08",
"act_comment": "Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:91273",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "tandospirone targets DRD2",
"source_label": "tandospirone",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.55",
"act_comment": "Binding affinity for DA2 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:91273",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "tandospirone targets DRD4",
"source_label": "tandospirone",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.14",
"act_comment": "Binding affinity to Dopamine receptor D4 was determined",
"act_source": "CHEMBL"
}
},
{
"source": "CID:91273",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "tandospirone targets HTR1A",
"source_label": "tandospirone",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.49",
"act_comment": "Binding affinity to 5-hydroxytryptamine 1A receptor was determined",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5381",
"relation": "IDG (Drug Target)",
"target": "5914",
"properties": {
"id": "tazarotene targets RARA",
"source_label": "tazarotene",
"target_label": "RARA",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "Activity at human RARalpha ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5381",
"relation": "IDG (Drug Target)",
"target": "5915",
"properties": {
"id": "tazarotene targets RARB",
"source_label": "tazarotene",
"target_label": "RARB",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "Activity at human RARbeta ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5381",
"relation": "IDG (Drug Target)",
"target": "5916",
"properties": {
"id": "tazarotene targets RARG",
"source_label": "tazarotene",
"target_label": "RARG",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "Activity at human RARgamma ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:135409453",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "tegaserod targets HTR2B",
"source_label": "tegaserod",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:135409453",
"relation": "IDG (Drug Target)",
"target": "3360",
"properties": {
"id": "tegaserod targets HTR4",
"source_label": "tegaserod",
"target_label": "HTR4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "Binding affinity at 5HT4 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65999",
"relation": "IDG (Drug Target)",
"target": "185",
"properties": {
"id": "telmisartan targets AGTR1",
"source_label": "telmisartan",
"target_label": "AGTR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.31",
"act_comment": "Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65999",
"relation": "IDG (Drug Target)",
"target": "186",
"properties": {
"id": "telmisartan targets AGTR2",
"source_label": "telmisartan",
"target_label": "AGTR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.48",
"act_comment": "Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1549008",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "terbinafine targets CYP2D6",
"source_label": "terbinafine",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.699",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1549008",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "terbinafine targets SIGMAR1",
"source_label": "terbinafine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.628",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1549008",
"relation": "IDG (Drug Target)",
"target": "6713",
"properties": {
"id": "terbinafine targets SQLE",
"source_label": "terbinafine",
"target_label": "SQLE",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "Inhibitory activity against Candida albicans Squalene Epoxidase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:441383",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "terconazole targets ADRA2A",
"source_label": "terconazole",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.433",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:441383",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "terconazole targets ADRA2C",
"source_label": "terconazole",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.215",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:441383",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "terconazole targets SIGMAR1",
"source_label": "terconazole",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.67",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5405",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "terfenadine targets ADRA2C",
"source_label": "terfenadine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.264",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5405",
"relation": "IDG (Drug Target)",
"target": "1234",
"properties": {
"id": "terfenadine targets CCR5",
"source_label": "terfenadine",
"target_label": "CCR5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5405",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "terfenadine targets DRD3",
"source_label": "terfenadine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.292",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5405",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "terfenadine targets HRH1",
"source_label": "terfenadine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.699",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5405",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "terfenadine targets HTR2A",
"source_label": "terfenadine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.137",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5405",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "terfenadine targets HTR2B",
"source_label": "terfenadine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.523",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5405",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "terfenadine targets HTR2C",
"source_label": "terfenadine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5405",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "terfenadine targets HTR6",
"source_label": "terfenadine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.218",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5405",
"relation": "IDG (Drug Target)",
"target": "3756",
"properties": {
"id": "terfenadine targets KCNH1",
"source_label": "terfenadine",
"target_label": "KCNH1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5405",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "terfenadine targets KCNH2",
"source_label": "terfenadine",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.252",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5405",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "terfenadine targets SLC6A3",
"source_label": "terfenadine",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.693",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5405",
"relation": "IDG (Drug Target)",
"target": "6865",
"properties": {
"id": "terfenadine targets TACR2",
"source_label": "terfenadine",
"target_label": "TACR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:11957722",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "terguride targets ADRA1A",
"source_label": "terguride",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11957722",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "terguride targets ADRA2A",
"source_label": "terguride",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11957722",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "terguride targets ADRA2B",
"source_label": "terguride",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11957722",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "terguride targets ADRA2C",
"source_label": "terguride",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11957722",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "terguride targets DRD2",
"source_label": "terguride",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11957722",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "terguride targets DRD3",
"source_label": "terguride",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11957722",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "terguride targets DRD4",
"source_label": "terguride",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11957722",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "terguride targets HTR1A",
"source_label": "terguride",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11957722",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "terguride targets HTR1B",
"source_label": "terguride",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11957722",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "terguride targets HTR1D",
"source_label": "terguride",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11957722",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "terguride targets HTR2A",
"source_label": "terguride",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11957722",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "terguride targets HTR2B",
"source_label": "terguride",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11957722",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "terguride targets HTR2C",
"source_label": "terguride",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:23480",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "terodiline targets KCNH2",
"source_label": "terodiline",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Inhibitory concentration against IKr potassium channel",
"act_source": "CHEMBL"
}
},
{
"source": "CID:36920",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "tertatolol targets ADRB3",
"source_label": "tertatolol",
"target_label": "ADRB3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:36920",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "tertatolol targets HTR1A",
"source_label": "tertatolol",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.087",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:6010",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "testosterone targets AR",
"source_label": "testosterone",
"target_label": "AR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6010",
"relation": "IDG (Drug Target)",
"target": "1588",
"properties": {
"id": "testosterone targets CYP19A1",
"source_label": "testosterone",
"target_label": "CYP19A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Inhibition of human placental aromatase Cytochrome P450 19A1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6010",
"relation": "IDG (Drug Target)",
"target": "866",
"properties": {
"id": "testosterone targets SERPINA6",
"source_label": "testosterone",
"target_label": "SERPINA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6010",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "testosterone targets SHBG",
"source_label": "testosterone",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.2",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6018",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "tetrabenazine targets ADRA2A",
"source_label": "tetrabenazine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.018",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6018",
"relation": "IDG (Drug Target)",
"target": "6571",
"properties": {
"id": "tetrabenazine targets SLC18A2",
"source_label": "tetrabenazine",
"target_label": "SLC18A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5411",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "tetracaine targets HTR2A",
"source_label": "tetracaine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.011",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5411",
"relation": "IDG (Drug Target)",
"target": "4128",
"properties": {
"id": "tetracaine targets MAOA",
"source_label": "tetracaine",
"target_label": "MAOA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.499",
"act_comment": "DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5411",
"relation": "IDG (Drug Target)",
"target": "6331",
"properties": {
"id": "tetracaine targets SCN5A",
"source_label": "tetracaine",
"target_label": "SCN5A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5411",
"relation": "IDG (Drug Target)",
"target": "6334",
"properties": {
"id": "tetracaine targets SCN8A",
"source_label": "tetracaine",
"target_label": "SCN8A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Inhibition of recombinant human Nav1.6 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mins by FRET assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5411",
"relation": "IDG (Drug Target)",
"target": "6335",
"properties": {
"id": "tetracaine targets SCN9A",
"source_label": "tetracaine",
"target_label": "SCN9A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Displacement of [3H]BTX from human Nav1.7 expressed in human HEK293 cells after 1 hr by MicroBeta analyzer",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5411",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "tetracaine targets SIGMAR1",
"source_label": "tetracaine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.153",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5426",
"relation": "IDG (Drug Target)",
"target": "51185",
"properties": {
"id": "thalidomide targets CRBN",
"source_label": "thalidomide",
"target_label": "CRBN",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.393",
"act_comment": "competitive titration of thalidomide with human DDB1-human CRBN (50 nM) and Cy5-thalidomide (20 nM)",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5426",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "thalidomide targets PTGS1",
"source_label": "thalidomide",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.432",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5426",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "thalidomide targets PTGS2",
"source_label": "thalidomide",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.301",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5426",
"relation": "IDG (Drug Target)",
"target": "7124",
"properties": {
"id": "thalidomide targets TNF",
"source_label": "thalidomide",
"target_label": "TNF",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2153",
"relation": "IDG (Drug Target)",
"target": "134",
"properties": {
"id": "theophylline targets ADORA1",
"source_label": "theophylline",
"target_label": "ADORA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.22",
"act_comment": "Binding affinity for adenosine A1 receptor by using as [3H]CPX iradioligand n membranes from Chinese hamster ovary cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2153",
"relation": "IDG (Drug Target)",
"target": "135",
"properties": {
"id": "theophylline targets ADORA2A",
"source_label": "theophylline",
"target_label": "ADORA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.22",
"act_comment": "Binding affinity for adenosine A2a receptor by using as [3H]ZM-241385 radioligand in membranes from HEK-A2A cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2153",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "theophylline targets ADORA3",
"source_label": "theophylline",
"target_label": "ADORA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Binding affinity for adenosine A3 receptor by displacement of specific binding of [125I]AB-MECA in membranes from CHO-A3 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5430",
"relation": "IDG (Drug Target)",
"target": "1544",
"properties": {
"id": "thiabendazole targets CYP1A2",
"source_label": "thiabendazole",
"target_label": "CYP1A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.097",
"act_comment": "DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5440",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "thiethylperazine targets ADRA1A",
"source_label": "thiethylperazine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.699",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5440",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "thiethylperazine targets DRD1",
"source_label": "thiethylperazine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.301",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5440",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "thiethylperazine targets DRD2",
"source_label": "thiethylperazine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.699",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5440",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "thiethylperazine targets DRD3",
"source_label": "thiethylperazine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.699",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5440",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "thiethylperazine targets HRH1",
"source_label": "thiethylperazine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.602",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5440",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "thiethylperazine targets HTR1A",
"source_label": "thiethylperazine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.155",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5440",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "thiethylperazine targets HTR2A",
"source_label": "thiethylperazine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5440",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "thiethylperazine targets HTR2B",
"source_label": "thiethylperazine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5440",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "thiethylperazine targets HTR2C",
"source_label": "thiethylperazine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5440",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "thiethylperazine targets SIGMAR1",
"source_label": "thiethylperazine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.155",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:1537",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "thioguanine targets PTGS1",
"source_label": "thioguanine",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.221",
"act_comment": "DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:9429",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "thioproperazine targets DRD2",
"source_label": "thioproperazine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.347",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:9429",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "thioproperazine targets DRD3",
"source_label": "thioproperazine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.921",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "thioridazine targets ADRA1A",
"source_label": "thioridazine",
"target_label": "ADRA1A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "thioridazine targets ADRA1B",
"source_label": "thioridazine",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.62",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "thioridazine targets ADRA1D",
"source_label": "thioridazine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.686",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "thioridazine targets ADRA2A",
"source_label": "thioridazine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.872",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "thioridazine targets ADRA2B",
"source_label": "thioridazine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.466",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "thioridazine targets ADRA2C",
"source_label": "thioridazine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.126",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "316",
"properties": {
"id": "thioridazine targets AOX1",
"source_label": "thioridazine",
"target_label": "AOX1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.796",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "thioridazine targets CHRM1",
"source_label": "thioridazine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.569",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "thioridazine targets CHRM2",
"source_label": "thioridazine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.854",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "thioridazine targets CHRM3",
"source_label": "thioridazine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.595",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "thioridazine targets CHRM4",
"source_label": "thioridazine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.046",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "thioridazine targets CHRM5",
"source_label": "thioridazine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.886",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "thioridazine targets DRD1",
"source_label": "thioridazine",
"target_label": "DRD1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "thioridazine targets DRD2",
"source_label": "thioridazine",
"target_label": "DRD2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "thioridazine targets DRD3",
"source_label": "thioridazine",
"target_label": "DRD3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "thioridazine targets DRD4",
"source_label": "thioridazine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.979",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "thioridazine targets HRH1",
"source_label": "thioridazine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "thioridazine targets HRH2",
"source_label": "thioridazine",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.866",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "thioridazine targets HTR1A",
"source_label": "thioridazine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "thioridazine targets HTR1B",
"source_label": "thioridazine",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.963",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "thioridazine targets HTR1D",
"source_label": "thioridazine",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.237",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "thioridazine targets HTR1E",
"source_label": "thioridazine",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.712",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "thioridazine targets HTR2A",
"source_label": "thioridazine",
"target_label": "HTR2A",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "thioridazine targets HTR2B",
"source_label": "thioridazine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.086",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "thioridazine targets HTR2C",
"source_label": "thioridazine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "thioridazine targets HTR5A",
"source_label": "thioridazine",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.439",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "thioridazine targets HTR6",
"source_label": "thioridazine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "thioridazine targets HTR7",
"source_label": "thioridazine",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "Binding affinity towards human 5-hydroxytryptamine 7 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "thioridazine targets KCNH2",
"source_label": "thioridazine",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "thioridazine targets OPRK1",
"source_label": "thioridazine",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.002",
"act_comment": "DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5452",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "thioridazine targets SIGMAR1",
"source_label": "thioridazine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.815",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "thiothixene targets ADRA1A",
"source_label": "thiothixene",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.94",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "thiothixene targets ADRA1B",
"source_label": "thiothixene",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.456",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "thiothixene targets ADRA2A",
"source_label": "thiothixene",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.097",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "thiothixene targets ADRA2B",
"source_label": "thiothixene",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "thiothixene targets ADRA2C",
"source_label": "thiothixene",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.284",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "thiothixene targets DRD1",
"source_label": "thiothixene",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.292",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "thiothixene targets DRD2",
"source_label": "thiothixene",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.347",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "thiothixene targets DRD3",
"source_label": "thiothixene",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.412",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "thiothixene targets DRD4",
"source_label": "thiothixene",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.693",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "thiothixene targets DRD5",
"source_label": "thiothixene",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.583",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "thiothixene targets HRH1",
"source_label": "thiothixene",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "thiothixene targets HRH2",
"source_label": "thiothixene",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.386",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "thiothixene targets HTR1A",
"source_label": "thiothixene",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.387",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "thiothixene targets HTR1B",
"source_label": "thiothixene",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.821",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "thiothixene targets HTR1D",
"source_label": "thiothixene",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.181",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "thiothixene targets HTR2A",
"source_label": "thiothixene",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "thiothixene targets HTR5A",
"source_label": "thiothixene",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.442",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "thiothixene targets HTR6",
"source_label": "thiothixene",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.681",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:941650",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "thiothixene targets HTR7",
"source_label": "thiothixene",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.817",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5819",
"relation": "IDG (Drug Target)",
"target": "5468",
"properties": {
"id": "levothyroxine targets PPARG",
"source_label": "levothyroxine",
"target_label": "PPARG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Binding affinity to recombinant PPARgamma LBD (unknown origin) by isothermal titration calorimetry",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5819",
"relation": "IDG (Drug Target)",
"target": "6256",
"properties": {
"id": "levothyroxine targets RXRA",
"source_label": "levothyroxine",
"target_label": "RXRA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "Binding affinity to RXRalpha LBD (unknown origin) by isothermal titration calorimetry",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5819",
"relation": "IDG (Drug Target)",
"target": "7067",
"properties": {
"id": "levothyroxine targets THRA",
"source_label": "levothyroxine",
"target_label": "THRA",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "Agonist activity at THRalpha (unknown origin) incubated for 14 to 16 hrs by dual glo luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5819",
"relation": "IDG (Drug Target)",
"target": "7068",
"properties": {
"id": "levothyroxine targets THRB",
"source_label": "levothyroxine",
"target_label": "THRB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:60648",
"relation": "IDG (Drug Target)",
"target": "6529",
"properties": {
"id": "tiagabine targets SLC6A1",
"source_label": "tiagabine",
"target_label": "SLC6A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5467",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "tiapride targets ADRA2A",
"source_label": "tiapride",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.108",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5467",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "tiapride targets DRD2",
"source_label": "tiapride",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.077",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5467",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "tiapride targets DRD3",
"source_label": "tiapride",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.756",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5467",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "tiapride targets DRD4",
"source_label": "tiapride",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.854",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5468",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "tiaprofenic acid targets PTGS2",
"source_label": "tiaprofenic acid",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:444008",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "tibolone targets ESR1",
"source_label": "tibolone",
"target_label": "ESR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.907",
"act_comment": "DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:444008",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "tibolone targets SLC6A4",
"source_label": "tibolone",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.317",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5472",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "ticlopidine targets ADRA2A",
"source_label": "ticlopidine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.845",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5472",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "ticlopidine targets ADRA2B",
"source_label": "ticlopidine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.857",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5472",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "ticlopidine targets ADRA2C",
"source_label": "ticlopidine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.767",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5472",
"relation": "IDG (Drug Target)",
"target": "1548",
"properties": {
"id": "ticlopidine targets CYP2A6",
"source_label": "ticlopidine",
"target_label": "CYP2A6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5472",
"relation": "IDG (Drug Target)",
"target": "1555",
"properties": {
"id": "ticlopidine targets CYP2B6",
"source_label": "ticlopidine",
"target_label": "CYP2B6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5472",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "ticlopidine targets CYP2C19",
"source_label": "ticlopidine",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.175",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5472",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "ticlopidine targets SIGMAR1",
"source_label": "ticlopidine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.747",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5482",
"relation": "IDG (Drug Target)",
"target": "1586",
"properties": {
"id": "tioconazole targets CYP17A1",
"source_label": "tioconazole",
"target_label": "CYP17A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "In vitro inhibition of human Cytochrome P450 17A1 activity",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5487427",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "tiotropium bromide targets CHRM1",
"source_label": "tiotropium bromide",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "11.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5487427",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "tiotropium bromide targets CHRM2",
"source_label": "tiotropium bromide",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "11.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5487427",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "tiotropium bromide targets CHRM3",
"source_label": "tiotropium bromide",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "11.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5487427",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "tiotropium bromide targets CHRM4",
"source_label": "tiotropium bromide",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "11.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5487427",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "tiotropium bromide targets CHRM5",
"source_label": "tiotropium bromide",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "11.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5487",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "tizanidine targets ADRA2A",
"source_label": "tizanidine",
"target_label": "ADRA2A",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.07",
"act_comment": "Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5487",
"relation": "IDG (Drug Target)",
"target": "11188",
"properties": {
"id": "tizanidine targets NISCH",
"source_label": "tizanidine",
"target_label": "NISCH",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.55",
"act_comment": "Displacement of [125I]PIC from human imidazoline receptor 1 in human platelets analyzed under norepinephrine mask of alpha 2AR",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5502",
"relation": "IDG (Drug Target)",
"target": "5144",
"properties": {
"id": "tofisopam targets PDE4D",
"source_label": "tofisopam",
"target_label": "PDE4D",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Inhibition of human PDE4D catalytic domain using [3H]-cAMP or [3H]-cGMP incubated for 30 mins by scintillation counting method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5504",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "tolazoline targets ADRA2A",
"source_label": "tolazoline",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4659569",
"relation": "IDG (Drug Target)",
"target": "1312",
"properties": {
"id": "tolcapone targets COMT",
"source_label": "tolcapone",
"target_label": "COMT",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.569",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:4659569",
"relation": "IDG (Drug Target)",
"target": "7276",
"properties": {
"id": "tolcapone targets TTR",
"source_label": "tolcapone",
"target_label": "TTR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.69",
"act_comment": "Binding affinity to transthyretin (unknown origin) by ITC method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:610479",
"relation": "IDG (Drug Target)",
"target": "8644",
"properties": {
"id": "tolfenamic acid targets AKR1C3",
"source_label": "tolfenamic acid",
"target_label": "AKR1C3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "Inhibition of human AKR1C3 using S-(+)-1,2,3,4-tetrahydro-1-naphthol as substrate",
"act_source": "CHEMBL"
}
},
{
"source": "CID:610479",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "tolfenamic acid targets PTGS1",
"source_label": "tolfenamic acid",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:610479",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "tolfenamic acid targets PTGS2",
"source_label": "tolfenamic acid",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5509",
"relation": "IDG (Drug Target)",
"target": "3576",
"properties": {
"id": "tolmetin targets CXCL8",
"source_label": "tolmetin",
"target_label": "CXCL8",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.05",
"act_comment": "Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5509",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "tolmetin targets PTGS1",
"source_label": "tolmetin",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.27",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5509",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "tolmetin targets PTGS2",
"source_label": "tolmetin",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.84",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:7084",
"relation": "IDG (Drug Target)",
"target": "4137",
"properties": {
"id": "tolonium targets MAPT",
"source_label": "tolonium",
"target_label": "MAPT",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.16",
"act_comment": "Inhibition of recombinant tau (unknown origin) aggregation",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5511",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "tolperisone targets ADRA2B",
"source_label": "tolperisone",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.341",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5511",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "tolperisone targets SIGMAR1",
"source_label": "tolperisone",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.253",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:53359",
"relation": "IDG (Drug Target)",
"target": "10327",
"properties": {
"id": "tolrestat targets AKR1A1",
"source_label": "tolrestat",
"target_label": "AKR1A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reduction",
"act_source": "CHEMBL"
}
},
{
"source": "CID:53359",
"relation": "IDG (Drug Target)",
"target": "231",
"properties": {
"id": "tolrestat targets AKR1B1",
"source_label": "tolrestat",
"target_label": "AKR1B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.509",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:53359",
"relation": "IDG (Drug Target)",
"target": "57016",
"properties": {
"id": "tolrestat targets AKR1B10",
"source_label": "tolrestat",
"target_label": "AKR1B10",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde reduction",
"act_source": "CHEMBL"
}
},
{
"source": "CID:443879",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "tolterodine targets CHRM1",
"source_label": "tolterodine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.85",
"act_comment": "Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M1 receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:443879",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "tolterodine targets CHRM2",
"source_label": "tolterodine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.57",
"act_comment": "Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:443879",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "tolterodine targets CHRM3",
"source_label": "tolterodine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.49",
"act_comment": "Binding affinity to human muscarinic M3 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:443879",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "tolterodine targets CHRM4",
"source_label": "tolterodine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.51",
"act_comment": "Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M4 receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:443879",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "tolterodine targets CHRM5",
"source_label": "tolterodine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.66",
"act_comment": "Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M5 receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:443879",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "tolterodine targets KCNH2",
"source_label": "tolterodine",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "Inhibitory concentration against potassium channel HERG",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284627",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "topiramate targets CA1",
"source_label": "topiramate",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Compound was evaluated for inhibition against human carbonic anhydrase I",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284627",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "topiramate targets CA12",
"source_label": "topiramate",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.42",
"act_comment": "Ki value against human carbonic anhydrase XII (hCA XII)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284627",
"relation": "IDG (Drug Target)",
"target": "377677",
"properties": {
"id": "topiramate targets CA13",
"source_label": "topiramate",
"target_label": "CA13",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.33",
"act_comment": "Inhibition of human recombinant CA13 by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284627",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "topiramate targets CA2",
"source_label": "topiramate",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "Compound was evaluated for inhibition against human carbonic anhydrase II",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284627",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "topiramate targets CA5A",
"source_label": "topiramate",
"target_label": "CA5A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "Inhibition of human carbonic anhydrase 5A",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284627",
"relation": "IDG (Drug Target)",
"target": "11238",
"properties": {
"id": "topiramate targets CA5B",
"source_label": "topiramate",
"target_label": "CA5B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "Inhibitory activity against human recombinant mitochondrial isozyme CA VB",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284627",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "topiramate targets CA6",
"source_label": "topiramate",
"target_label": "CA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.35",
"act_comment": "Inhibition of full length human recombinant CA VI",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284627",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "topiramate targets CA7",
"source_label": "topiramate",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.06",
"act_comment": "Ki value against human carbonic anhydrase VII",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284627",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "topiramate targets CA9",
"source_label": "topiramate",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.24",
"act_comment": "Compound was evaluated for inhibition against human carbonic anhydrase IX",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60700",
"relation": "IDG (Drug Target)",
"target": "3091",
"properties": {
"id": "topotecan targets HIF1A",
"source_label": "topotecan",
"target_label": "HIF1A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.22",
"act_comment": "Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60700",
"relation": "IDG (Drug Target)",
"target": "7150",
"properties": {
"id": "topotecan targets TOP1",
"source_label": "topotecan",
"target_label": "TOP1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.58",
"act_comment": "Binding affinity to topoisomerase 1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:41781",
"relation": "IDG (Drug Target)",
"target": "6557",
"properties": {
"id": "torsemide targets SLC12A1",
"source_label": "torsemide",
"target_label": "SLC12A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:667511",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "tramadol targets OPRD1",
"source_label": "tramadol",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.03",
"act_comment": "Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:667511",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "tramadol targets OPRK1",
"source_label": "tramadol",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:667511",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "tramadol targets SLC6A2",
"source_label": "tramadol",
"target_label": "SLC6A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Inhibition of reuptake of Norepinephrine",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5484727",
"relation": "IDG (Drug Target)",
"target": "1636",
"properties": {
"id": "trandolapril targets ACE",
"source_label": "trandolapril",
"target_label": "ACE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.12",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5702124",
"relation": "IDG (Drug Target)",
"target": "1548",
"properties": {
"id": "tranylcypromine targets CYP2A6",
"source_label": "tranylcypromine",
"target_label": "CYP2A6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.187",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5702124",
"relation": "IDG (Drug Target)",
"target": "4128",
"properties": {
"id": "tranylcypromine targets MAOA",
"source_label": "tranylcypromine",
"target_label": "MAOA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Inhibition of human recombinant MAO-A assessed as kynuramine oxidation to 4-hydroxyquinoline after 40 mins by LC-MS/MS analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5702124",
"relation": "IDG (Drug Target)",
"target": "4129",
"properties": {
"id": "tranylcypromine targets MAOB",
"source_label": "tranylcypromine",
"target_label": "MAOB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.48",
"act_comment": "Compound was evaluated for inhibition of Microbial tyramine oxidase; irreversible",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5282226",
"relation": "IDG (Drug Target)",
"target": "5737",
"properties": {
"id": "travoprost targets PTGFR",
"source_label": "travoprost",
"target_label": "PTGFR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.284",
"act_comment": "inhibition of [3H]AL-5848 binding to prostaglandin FP receptor",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5533",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "trazodone targets ADRA1A",
"source_label": "trazodone",
"target_label": "ADRA1A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.551",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5533",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "trazodone targets ADRA1D",
"source_label": "trazodone",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.328",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5533",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "trazodone targets ADRA2A",
"source_label": "trazodone",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.58",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5533",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "trazodone targets ADRA2B",
"source_label": "trazodone",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.75",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5533",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "trazodone targets ADRA2C",
"source_label": "trazodone",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.81",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5533",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "trazodone targets HRH1",
"source_label": "trazodone",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5533",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "trazodone targets HTR1A",
"source_label": "trazodone",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.018",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5533",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "trazodone targets HTR1D",
"source_label": "trazodone",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.975",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5533",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "trazodone targets HTR2A",
"source_label": "trazodone",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.35",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5533",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "trazodone targets HTR2B",
"source_label": "trazodone",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.08",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5533",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "trazodone targets HTR2C",
"source_label": "trazodone",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.65",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5533",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "trazodone targets SIGMAR1",
"source_label": "trazodone",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.033",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5533",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "trazodone targets SLC6A4",
"source_label": "trazodone",
"target_label": "SLC6A4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:73707411",
"relation": "IDG (Drug Target)",
"target": "5729",
"properties": {
"id": "treprostinil targets PTGDR",
"source_label": "treprostinil",
"target_label": "PTGDR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:73707411",
"relation": "IDG (Drug Target)",
"target": "5731",
"properties": {
"id": "treprostinil targets PTGER1",
"source_label": "treprostinil",
"target_label": "PTGER1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:73707411",
"relation": "IDG (Drug Target)",
"target": "5732",
"properties": {
"id": "treprostinil targets PTGER2",
"source_label": "treprostinil",
"target_label": "PTGER2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:73707411",
"relation": "IDG (Drug Target)",
"target": "5734",
"properties": {
"id": "treprostinil targets PTGER4",
"source_label": "treprostinil",
"target_label": "PTGER4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:73707411",
"relation": "IDG (Drug Target)",
"target": "5739",
"properties": {
"id": "treprostinil targets PTGIR",
"source_label": "treprostinil",
"target_label": "PTGIR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.72",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:444795",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "tretinoin targets HTR2B",
"source_label": "tretinoin",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.642",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:444795",
"relation": "IDG (Drug Target)",
"target": "5594",
"properties": {
"id": "tretinoin targets MAPK1",
"source_label": "tretinoin",
"target_label": "MAPK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:444795",
"relation": "IDG (Drug Target)",
"target": "5300",
"properties": {
"id": "tretinoin targets PIN1",
"source_label": "tretinoin",
"target_label": "PIN1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Inhibition of human N-terminal His6-tagged Pin1 PPIase activity expressed in Escherichia coli BL21 using Suc-Ala-Glu-cis-Pro-Phe-4-nitroanilide as substrate preincubated for 10 mins followed by substrate addition monitored for 90 secs by protease enzyme coupled based spectrophotometric analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:444795",
"relation": "IDG (Drug Target)",
"target": "5467",
"properties": {
"id": "tretinoin targets PPARD",
"source_label": "tretinoin",
"target_label": "PPARD",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:444795",
"relation": "IDG (Drug Target)",
"target": "5914",
"properties": {
"id": "tretinoin targets RARA",
"source_label": "tretinoin",
"target_label": "RARA",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:444795",
"relation": "IDG (Drug Target)",
"target": "5915",
"properties": {
"id": "tretinoin targets RARB",
"source_label": "tretinoin",
"target_label": "RARB",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:444795",
"relation": "IDG (Drug Target)",
"target": "5916",
"properties": {
"id": "tretinoin targets RARG",
"source_label": "tretinoin",
"target_label": "RARG",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:444795",
"relation": "IDG (Drug Target)",
"target": "5959",
"properties": {
"id": "tretinoin targets RDH5",
"source_label": "tretinoin",
"target_label": "RDH5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:444795",
"relation": "IDG (Drug Target)",
"target": "6095",
"properties": {
"id": "tretinoin targets RORA",
"source_label": "tretinoin",
"target_label": "RORA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:444795",
"relation": "IDG (Drug Target)",
"target": "6096",
"properties": {
"id": "tretinoin targets RORB",
"source_label": "tretinoin",
"target_label": "RORB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.82",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:444795",
"relation": "IDG (Drug Target)",
"target": "6097",
"properties": {
"id": "tretinoin targets RORC",
"source_label": "tretinoin",
"target_label": "RORC",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:444795",
"relation": "IDG (Drug Target)",
"target": "6256",
"properties": {
"id": "tretinoin targets RXRA",
"source_label": "tretinoin",
"target_label": "RXRA",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "Binding affinity for retinoic acid receptor RAR alpha",
"act_source": "CHEMBL"
}
},
{
"source": "CID:444795",
"relation": "IDG (Drug Target)",
"target": "6257",
"properties": {
"id": "tretinoin targets RXRB",
"source_label": "tretinoin",
"target_label": "RXRB",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "Binding affinity for retinoic acid receptor RAR beta",
"act_source": "CHEMBL"
}
},
{
"source": "CID:444795",
"relation": "IDG (Drug Target)",
"target": "6258",
"properties": {
"id": "tretinoin targets RXRG",
"source_label": "tretinoin",
"target_label": "RXRG",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.85",
"act_comment": "Binding affinity for retinoic acid receptor RAR gamma",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65772",
"relation": "IDG (Drug Target)",
"target": "6915",
"properties": {
"id": "tretoquinol targets TBXA2R",
"source_label": "tretoquinol",
"target_label": "TBXA2R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Inhibitory concentration against radioligand [3H]SQ-29,548 (5 nM) binding to TP receptors in human platelets",
"act_source": "CHEMBL"
}
},
{
"source": "CID:31307",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "triamcinolone targets NR3C1",
"source_label": "triamcinolone",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.585",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6436",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "triamcinolone acetonide targets NR3C1",
"source_label": "triamcinolone acetonide",
"target_label": "NR3C1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5560",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "trichlormethiazide targets CA1",
"source_label": "trichlormethiazide",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5560",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "trichlormethiazide targets CA12",
"source_label": "trichlormethiazide",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5560",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "trichlormethiazide targets CA2",
"source_label": "trichlormethiazide",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.04",
"act_comment": "Inhibition of human recombinant full length CA2 by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5560",
"relation": "IDG (Drug Target)",
"target": "762",
"properties": {
"id": "trichlormethiazide targets CA4",
"source_label": "trichlormethiazide",
"target_label": "CA4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5560",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "trichlormethiazide targets CA5A",
"source_label": "trichlormethiazide",
"target_label": "CA5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5560",
"relation": "IDG (Drug Target)",
"target": "11238",
"properties": {
"id": "trichlormethiazide targets CA5B",
"source_label": "trichlormethiazide",
"target_label": "CA5B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.87",
"act_comment": "Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5560",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "trichlormethiazide targets CA7",
"source_label": "trichlormethiazide",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5560",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "trichlormethiazide targets CA9",
"source_label": "trichlormethiazide",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.06",
"act_comment": "Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5560",
"relation": "IDG (Drug Target)",
"target": "6559",
"properties": {
"id": "trichlormethiazide targets SLC12A3",
"source_label": "trichlormethiazide",
"target_label": "SLC12A3",
"act_type": "A2",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5566",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "trifluoperazine targets ADRA1A",
"source_label": "trifluoperazine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.62",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5566",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "trifluoperazine targets ADRA2A",
"source_label": "trifluoperazine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.185",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5566",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "trifluoperazine targets ADRA2B",
"source_label": "trifluoperazine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.786",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5566",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "trifluoperazine targets ADRA2C",
"source_label": "trifluoperazine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.407",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5566",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "trifluoperazine targets CHRM3",
"source_label": "trifluoperazine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5566",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "trifluoperazine targets DRD2",
"source_label": "trifluoperazine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.841",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5566",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "trifluoperazine targets DRD3",
"source_label": "trifluoperazine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.251",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5566",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "trifluoperazine targets DRD4",
"source_label": "trifluoperazine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.377",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5566",
"relation": "IDG (Drug Target)",
"target": "10682",
"properties": {
"id": "trifluoperazine targets EBP",
"source_label": "trifluoperazine",
"target_label": "EBP",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "Affinity for human EMP expressed in ERG2 deficient strain of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5566",
"relation": "IDG (Drug Target)",
"target": "84650",
"properties": {
"id": "trifluoperazine targets EBPL",
"source_label": "trifluoperazine",
"target_label": "EBPL",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.41",
"act_comment": "Binding affinity to emopamil binding protein (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5566",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "trifluoperazine targets HRH1",
"source_label": "trifluoperazine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5566",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "trifluoperazine targets HTR1A",
"source_label": "trifluoperazine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.022",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5566",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "trifluoperazine targets HTR2A",
"source_label": "trifluoperazine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5566",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "trifluoperazine targets HTR2C",
"source_label": "trifluoperazine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5566",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "trifluoperazine targets HTR6",
"source_label": "trifluoperazine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.849",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5566",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "trifluoperazine targets HTR7",
"source_label": "trifluoperazine",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.536",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5566",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "trifluoperazine targets SIGMAR1",
"source_label": "trifluoperazine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.82",
"act_comment": "Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5567",
"relation": "IDG (Drug Target)",
"target": "10682",
"properties": {
"id": "trifluperidol targets EBP",
"source_label": "trifluperidol",
"target_label": "EBP",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.78",
"act_comment": "Affinity for human EMP expressed in ERG2 deficient strain of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5567",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "trifluperidol targets SIGMAR1",
"source_label": "trifluperidol",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.08",
"act_comment": "Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5568",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "triflupromazine targets DRD2",
"source_label": "triflupromazine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.553",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5568",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "triflupromazine targets HTR2A",
"source_label": "triflupromazine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.398",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5572",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "trihexyphenidyl targets CHRM1",
"source_label": "trihexyphenidyl",
"target_label": "CHRM1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.89",
"act_comment": "Evaluated for its binding affinity at human muscarinic receptor m1 by displacement of [3H]NMS binding using membranes in transfected chinese hamster ovarian cell",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5572",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "trihexyphenidyl targets CHRM2",
"source_label": "trihexyphenidyl",
"target_label": "CHRM2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.73",
"act_comment": "Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5572",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "trihexyphenidyl targets CHRM3",
"source_label": "trihexyphenidyl",
"target_label": "CHRM3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.58",
"act_comment": "Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5572",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "trihexyphenidyl targets CHRM4",
"source_label": "trihexyphenidyl",
"target_label": "CHRM4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.17",
"act_comment": "Evaluated for its binding affinity at human muscarinic receptor m4 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5572",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "trihexyphenidyl targets CHRM5",
"source_label": "trihexyphenidyl",
"target_label": "CHRM5",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.99",
"act_comment": "Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5572",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "trihexyphenidyl targets SIGMAR1",
"source_label": "trihexyphenidyl",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.347",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5578",
"relation": "IDG (Drug Target)",
"target": "1719",
"properties": {
"id": "trimethoprim targets DHFR",
"source_label": "trimethoprim",
"target_label": "DHFR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Inhibition of recombinant Dihydrofolate reductase from humans.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5583",
"relation": "IDG (Drug Target)",
"target": "1719",
"properties": {
"id": "trimetrexate targets DHFR",
"source_label": "trimetrexate",
"target_label": "DHFR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.85",
"act_comment": "Inhibition of human recombinant Dihydrofolate reductase enzyme",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5584",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "trimipramine targets HRH1",
"source_label": "trimipramine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.854",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5584",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "trimipramine targets SLC6A4",
"source_label": "trimipramine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.827",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5585",
"relation": "IDG (Drug Target)",
"target": "135",
"properties": {
"id": "trioxsalen targets ADORA2A",
"source_label": "trioxsalen",
"target_label": "ADORA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.133",
"act_comment": "DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5585",
"relation": "IDG (Drug Target)",
"target": "4128",
"properties": {
"id": "trioxsalen targets MAOA",
"source_label": "trioxsalen",
"target_label": "MAOA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.08",
"act_comment": "DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6536",
"relation": "IDG (Drug Target)",
"target": "10682",
"properties": {
"id": "triparanol targets EBP",
"source_label": "triparanol",
"target_label": "EBP",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Affinity for human EMP expressed in ERG2 deficient strain of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6536",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "triparanol targets SIGMAR1",
"source_label": "triparanol",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5587",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "tripelennamine targets HRH1",
"source_label": "tripelennamine",
"target_label": "HRH1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "Inhibitory activity against human Histamine H1 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5282443",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "triprolidine targets HRH1",
"source_label": "triprolidine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.9",
"act_comment": "GRAC: human H1 selective antagonist",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5591",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "troglitazone targets CA2",
"source_label": "troglitazone",
"target_label": "CA2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.013",
"act_comment": "DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA))",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5591",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "troglitazone targets HTR2B",
"source_label": "troglitazone",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.078",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5591",
"relation": "IDG (Drug Target)",
"target": "5468",
"properties": {
"id": "troglitazone targets PPARG",
"source_label": "troglitazone",
"target_label": "PPARG",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.27",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:202225",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "troleandomycin targets CYP3A4",
"source_label": "troleandomycin",
"target_label": "CYP3A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5593",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "tropicamide targets CHRM1",
"source_label": "tropicamide",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.167",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5593",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "tropicamide targets CHRM2",
"source_label": "tropicamide",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.432",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5593",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "tropicamide targets CHRM3",
"source_label": "tropicamide",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.523",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5593",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "tropicamide targets CHRM4",
"source_label": "tropicamide",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.46",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5593",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "tropicamide targets CHRM5",
"source_label": "tropicamide",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.194",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5593",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "tropicamide targets CYP2C19",
"source_label": "tropicamide",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5593",
"relation": "IDG (Drug Target)",
"target": "1559",
"properties": {
"id": "tropicamide targets CYP2C9",
"source_label": "tropicamide",
"target_label": "CYP2C9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:656665",
"relation": "IDG (Drug Target)",
"target": "1139",
"properties": {
"id": "tropisetron targets CHRNA7",
"source_label": "tropisetron",
"target_label": "CHRNA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.16",
"act_comment": "Inhibition constant against nicotinic acetylcholine receptor alpha7",
"act_source": "CHEMBL"
}
},
{
"source": "CID:656665",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "tropisetron targets HTR1A",
"source_label": "tropisetron",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.28",
"act_comment": "Inhibition constant against 5-hydroxytryptamine 1A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:656665",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "tropisetron targets HTR3A",
"source_label": "tropisetron",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:656665",
"relation": "IDG (Drug Target)",
"target": "9177",
"properties": {
"id": "tropisetron targets HTR3B",
"source_label": "tropisetron",
"target_label": "HTR3B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "GRAC: human 5-HT3B selective antagonist",
"act_source": "CHEMBL"
}
},
{
"source": "CID:656665",
"relation": "IDG (Drug Target)",
"target": "3360",
"properties": {
"id": "tropisetron targets HTR4",
"source_label": "tropisetron",
"target_label": "HTR4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:656665",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "tropisetron targets SLC6A4",
"source_label": "tropisetron",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.587",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5284632",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "trospium targets CHRM1",
"source_label": "trospium",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.46",
"act_comment": "Displacement of [3H]NMS from human recombinant muscarinic receptor M1 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284632",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "trospium targets CHRM2",
"source_label": "trospium",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.94",
"act_comment": "Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284632",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "trospium targets CHRM3",
"source_label": "trospium",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.99",
"act_comment": "Displacement of [3H]NMS from human recombinant muscarinic receptor M3 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284632",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "trospium targets CHRM4",
"source_label": "trospium",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.84",
"act_comment": "Displacement of [3H]NMS from human recombinant muscarinic receptor M4 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5284632",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "trospium targets CHRM5",
"source_label": "trospium",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "Displacement of [3H]NMS from human recombinant muscarinic receptor M5 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6000",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "tubocurarine targets CHRM2",
"source_label": "tubocurarine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.013",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6000",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "tubocurarine targets HTR3A",
"source_label": "tubocurarine",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.06",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:153005",
"relation": "IDG (Drug Target)",
"target": "134864",
"properties": {
"id": "tyramine targets TAAR1",
"source_label": "tyramine",
"target_label": "TAAR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.16",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:72172",
"relation": "IDG (Drug Target)",
"target": "51056",
"properties": {
"id": "ubenimex targets LAP3",
"source_label": "ubenimex",
"target_label": "LAP3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.22",
"act_comment": "Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidney",
"act_source": "CHEMBL"
}
},
{
"source": "CID:72172",
"relation": "IDG (Drug Target)",
"target": "4048",
"properties": {
"id": "ubenimex targets LTA4H",
"source_label": "ubenimex",
"target_label": "LTA4H",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Inhibition of aminopeptidase activity of human leukotriene A4 hydrolase by Dixon plot analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5639",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "urapidil targets ADRA1A",
"source_label": "urapidil",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.85",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5639",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "urapidil targets ADRA1B",
"source_label": "urapidil",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5639",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "urapidil targets ADRA1D",
"source_label": "urapidil",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5639",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "urapidil targets HTR1A",
"source_label": "urapidil",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.456",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:119607",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "valdecoxib targets CA12",
"source_label": "valdecoxib",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Inhibitory activity against cloned human CA12",
"act_source": "CHEMBL"
}
},
{
"source": "CID:119607",
"relation": "IDG (Drug Target)",
"target": "377677",
"properties": {
"id": "valdecoxib targets CA13",
"source_label": "valdecoxib",
"target_label": "CA13",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "Inhibition of human recombinant CA13 catalytic domain pre-incubated for 15 mins by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:119607",
"relation": "IDG (Drug Target)",
"target": "23632",
"properties": {
"id": "valdecoxib targets CA14",
"source_label": "valdecoxib",
"target_label": "CA14",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.97",
"act_comment": "Inhibition of human recombinant CA14 catalytic domain pre-incubated for 15 mins by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:119607",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "valdecoxib targets CA2",
"source_label": "valdecoxib",
"target_label": "CA2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.37",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:119607",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "valdecoxib targets CA5A",
"source_label": "valdecoxib",
"target_label": "CA5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "Inhibition of human recombinant full length CA5A pre-incubated for 15 mins by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:119607",
"relation": "IDG (Drug Target)",
"target": "11238",
"properties": {
"id": "valdecoxib targets CA5B",
"source_label": "valdecoxib",
"target_label": "CA5B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.06",
"act_comment": "Inhibition of human recombinant full length CA5B pre-incubated for 15 mins by stopped-flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:119607",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "valdecoxib targets CA6",
"source_label": "valdecoxib",
"target_label": "CA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:119607",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "valdecoxib targets CA9",
"source_label": "valdecoxib",
"target_label": "CA9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.57",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:119607",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "valdecoxib targets PTGS2",
"source_label": "valdecoxib",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5648",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "valethamate targets CHRM1",
"source_label": "valethamate",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.56",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5648",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "valethamate targets CHRM2",
"source_label": "valethamate",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5648",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "valethamate targets CHRM3",
"source_label": "valethamate",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.25",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5648",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "valethamate targets CHRM4",
"source_label": "valethamate",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.44",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5648",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "valethamate targets CHRM5",
"source_label": "valethamate",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.62",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5648",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "valethamate targets CYP2D6",
"source_label": "valethamate",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5648",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "valethamate targets SIGMAR1",
"source_label": "valethamate",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3121",
"relation": "IDG (Drug Target)",
"target": "3065",
"properties": {
"id": "valproic acid targets HDAC1",
"source_label": "valproic acid",
"target_label": "HDAC1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:73707482",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "vancomycin targets ADRA2A",
"source_label": "vancomycin",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5310966",
"relation": "IDG (Drug Target)",
"target": "1139",
"properties": {
"id": "varenicline targets CHRNA7",
"source_label": "varenicline",
"target_label": "CHRNA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "Displacement of [3H]epibatidine from alpha7 nicotinic receptor expressed in human HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:110634",
"relation": "IDG (Drug Target)",
"target": "10846",
"properties": {
"id": "vardenafil targets PDE10A",
"source_label": "vardenafil",
"target_label": "PDE10A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Inhibitory concentration against human phosphodiesterase 10",
"act_source": "CHEMBL"
}
},
{
"source": "CID:110634",
"relation": "IDG (Drug Target)",
"target": "50940",
"properties": {
"id": "vardenafil targets PDE11A",
"source_label": "vardenafil",
"target_label": "PDE11A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Inhibition of human phosphodiesterase 11",
"act_source": "CHEMBL"
}
},
{
"source": "CID:110634",
"relation": "IDG (Drug Target)",
"target": "5136",
"properties": {
"id": "vardenafil targets PDE1A",
"source_label": "vardenafil",
"target_label": "PDE1A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.041",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:110634",
"relation": "IDG (Drug Target)",
"target": "8654",
"properties": {
"id": "vardenafil targets PDE5A",
"source_label": "vardenafil",
"target_label": "PDE5A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.155",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:110634",
"relation": "IDG (Drug Target)",
"target": "5145",
"properties": {
"id": "vardenafil targets PDE6A",
"source_label": "vardenafil",
"target_label": "PDE6A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.465",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:110634",
"relation": "IDG (Drug Target)",
"target": "5152",
"properties": {
"id": "vardenafil targets PDE9A",
"source_label": "vardenafil",
"target_label": "PDE9A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.34",
"act_comment": "Inhibition of Phosphodiesterase 9",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644077",
"relation": "IDG (Drug Target)",
"target": "552",
"properties": {
"id": "vasopressin targets AVPR1A",
"source_label": "vasopressin",
"target_label": "AVPR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.59",
"act_comment": "Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranes",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644077",
"relation": "IDG (Drug Target)",
"target": "553",
"properties": {
"id": "vasopressin targets AVPR1B",
"source_label": "vasopressin",
"target_label": "AVPR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.31",
"act_comment": "Displacement of [3H]-AVP from human vasopressin V1b receptor expressed in CHO cells after 30 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644077",
"relation": "IDG (Drug Target)",
"target": "554",
"properties": {
"id": "vasopressin targets AVPR2",
"source_label": "vasopressin",
"target_label": "AVPR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.92",
"act_comment": "Displacement of [3H]AVP from human vasopressin V2 receptor expressed CHO cells after 60 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:644077",
"relation": "IDG (Drug Target)",
"target": "5021",
"properties": {
"id": "vasopressin targets OXTR",
"source_label": "vasopressin",
"target_label": "OXTR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.78",
"act_comment": "Displacement of [3H]-AVP from human oxytocin receptor expressed in CHO cells after 30 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57369718",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "vecuronium targets CHRM1",
"source_label": "vecuronium",
"target_label": "CHRM1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.9",
"act_comment": "Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57369718",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "vecuronium targets CHRM2",
"source_label": "vecuronium",
"target_label": "CHRM2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57369718",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "vecuronium targets CHRM3",
"source_label": "vecuronium",
"target_label": "CHRM3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.6",
"act_comment": "Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57369718",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "vecuronium targets CHRM4",
"source_label": "vecuronium",
"target_label": "CHRM4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.8",
"act_comment": "Displacement of [3H]NMS from human muscarinic M4 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57369718",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "vecuronium targets CHRM5",
"source_label": "vecuronium",
"target_label": "CHRM5",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5656",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "venlafaxine targets SLC6A4",
"source_label": "venlafaxine",
"target_label": "SLC6A4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.051",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2520",
"relation": "IDG (Drug Target)",
"target": "5243",
"properties": {
"id": "verapamil targets ABCB1",
"source_label": "verapamil",
"target_label": "ABCB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity model",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2520",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "verapamil targets ADRA1D",
"source_label": "verapamil",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.072",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2520",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "verapamil targets ADRA2A",
"source_label": "verapamil",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.664",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2520",
"relation": "IDG (Drug Target)",
"target": "775",
"properties": {
"id": "verapamil targets CACNA1C",
"source_label": "verapamil",
"target_label": "CACNA1C",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:2520",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "verapamil targets CYP3A4",
"source_label": "verapamil",
"target_label": "CYP3A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Inhibition of testosterone 6β-hydroxylation.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2520",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "verapamil targets DRD3",
"source_label": "verapamil",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.201",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2520",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "verapamil targets HTR2A",
"source_label": "verapamil",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.854",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:2520",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "verapamil targets HTR2B",
"source_label": "verapamil",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.979",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2520",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "verapamil targets HTR2C",
"source_label": "verapamil",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.81",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2520",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "verapamil targets KCNH2",
"source_label": "verapamil",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Inhibition of human ERG",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2520",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "verapamil targets SLC6A4",
"source_label": "verapamil",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.896",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:21704",
"relation": "IDG (Drug Target)",
"target": "1803",
"properties": {
"id": "vidarabine targets DPP4",
"source_label": "vidarabine",
"target_label": "DPP4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.21",
"act_comment": "Inhibition of human DPP4 from human Caco-2 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5666",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "viloxazine targets SLC6A2",
"source_label": "viloxazine",
"target_label": "SLC6A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Possible mechanism of action in ADHD",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:5666",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "viloxazine targets SLC6A3",
"source_label": "viloxazine",
"target_label": "SLC6A3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.81",
"act_comment": "Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDAT",
"act_source": "CHEMBL"
}
},
{
"source": "CID:13342",
"relation": "IDG (Drug Target)",
"target": "5243",
"properties": {
"id": "vinblastine targets ABCB1",
"source_label": "vinblastine",
"target_label": "ABCB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity model",
"act_source": "CHEMBL"
}
},
{
"source": "CID:73707409",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "vinorelbine targets CYP3A4",
"source_label": "vinorelbine",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:73707409",
"relation": "IDG (Drug Target)",
"target": "6865",
"properties": {
"id": "vinorelbine targets TACR2",
"source_label": "vinorelbine",
"target_label": "TACR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.271",
"act_comment": "DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:443955",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "vinpocetine targets KCNH2",
"source_label": "vinpocetine",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.41",
"act_comment": "Inhibition of human ERG",
"act_source": "CHEMBL"
}
},
{
"source": "CID:445354",
"relation": "IDG (Drug Target)",
"target": "5950",
"properties": {
"id": "retinol targets RBP4",
"source_label": "retinol",
"target_label": "RBP4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Binding affinity to His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as apparent dissociation constant after 5 mins by fluorescence spectrophotometric analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:938",
"relation": "IDG (Drug Target)",
"target": "338442",
"properties": {
"id": "nicotinic acid targets HCAR2",
"source_label": "nicotinic acid",
"target_label": "HCAR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:938",
"relation": "IDG (Drug Target)",
"target": "8843",
"properties": {
"id": "nicotinic acid targets HCAR3",
"source_label": "nicotinic acid",
"target_label": "HCAR3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5280795",
"relation": "IDG (Drug Target)",
"target": "2741",
"properties": {
"id": "colecalciferol targets GLRA1",
"source_label": "colecalciferol",
"target_label": "GLRA1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280795",
"relation": "IDG (Drug Target)",
"target": "7421",
"properties": {
"id": "colecalciferol targets VDR",
"source_label": "colecalciferol",
"target_label": "VDR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.68",
"act_comment": "Agonist activity at human VDR expressed in HEK293 cells by luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:444020",
"relation": "IDG (Drug Target)",
"target": "2548",
"properties": {
"id": "voglibose targets GAA",
"source_label": "voglibose",
"target_label": "GAA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "Inhibition of maltase in human Caco-2 cell model system after 2 hrs",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71616",
"relation": "IDG (Drug Target)",
"target": "10858",
"properties": {
"id": "voriconazole targets CYP46A1",
"source_label": "voriconazole",
"target_label": "CYP46A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Inhibition of full-length recombinant human CYP46A1 assessed as reduction in cholesterol 24-hydroxylation using cholesterol as substrate in presence of NADPH cytochrome P450 oxidoreductase by gas chromatography-mass spectrometry",
"act_source": "CHEMBL"
}
},
{
"source": "CID:54688261",
"relation": "IDG (Drug Target)",
"target": "79001",
"properties": {
"id": "warfarin targets VKORC1",
"source_label": "warfarin",
"target_label": "VKORC1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:155774",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "xamoterol targets ADRB1",
"source_label": "xamoterol",
"target_label": "ADRB1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.75",
"act_comment": "Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs",
"act_source": "CHEMBL"
}
},
{
"source": "CID:155774",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "xamoterol targets ADRB2",
"source_label": "xamoterol",
"target_label": "ADRB2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.18",
"act_comment": "Antagonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9574101",
"relation": "IDG (Drug Target)",
"target": "2147",
"properties": {
"id": "ximelagatran targets F2",
"source_label": "ximelagatran",
"target_label": "F2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.432",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5717",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "zafirlukast targets ADORA3",
"source_label": "zafirlukast",
"target_label": "ADORA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.114",
"act_comment": "DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5717",
"relation": "IDG (Drug Target)",
"target": "10800",
"properties": {
"id": "zafirlukast targets CYSLTR1",
"source_label": "zafirlukast",
"target_label": "CYSLTR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.5",
"act_comment": "GRAC: human CysLT1 selective antagonist",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5717",
"relation": "IDG (Drug Target)",
"target": "5594",
"properties": {
"id": "zafirlukast targets MAPK1",
"source_label": "zafirlukast",
"target_label": "MAPK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.269",
"act_comment": "DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5717",
"relation": "IDG (Drug Target)",
"target": "1432",
"properties": {
"id": "zafirlukast targets MAPK14",
"source_label": "zafirlukast",
"target_label": "MAPK14",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.452",
"act_comment": "DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:60490",
"relation": "IDG (Drug Target)",
"target": "246",
"properties": {
"id": "zileuton targets ALOX15",
"source_label": "zileuton",
"target_label": "ALOX15",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Inhibition of 15-LOX in human primary polymorphonuclear leukocytes",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60490",
"relation": "IDG (Drug Target)",
"target": "240",
"properties": {
"id": "zileuton targets ALOX5",
"source_label": "zileuton",
"target_label": "ALOX5",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Inhibition of 5-LOX (unknown origin) using arachidonic acid as substrate after 5 mins by EIA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60490",
"relation": "IDG (Drug Target)",
"target": "2053",
"properties": {
"id": "zileuton targets EPHX2",
"source_label": "zileuton",
"target_label": "EPHX2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.23",
"act_comment": "Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60490",
"relation": "IDG (Drug Target)",
"target": "4048",
"properties": {
"id": "zileuton targets LTA4H",
"source_label": "zileuton",
"target_label": "LTA4H",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.071",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60490",
"relation": "IDG (Drug Target)",
"target": "1241",
"properties": {
"id": "zileuton targets LTB4R",
"source_label": "zileuton",
"target_label": "LTB4R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophils",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60490",
"relation": "IDG (Drug Target)",
"target": "9536",
"properties": {
"id": "zileuton targets PTGES",
"source_label": "zileuton",
"target_label": "PTGES",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Inhibition of mPGES-1 isolated from microsomes of interleukin-1 beta-stimulated human A549 cells using PGH2 as substrate preincubated for 15 mins followed by substrate addition measured after 1 min by RP-HPLC analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "ziprasidone targets ADRA1A",
"source_label": "ziprasidone",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "ziprasidone targets ADRA1B",
"source_label": "ziprasidone",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.046",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "ziprasidone targets ADRA2A",
"source_label": "ziprasidone",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "ziprasidone targets ADRA2B",
"source_label": "ziprasidone",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.319",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "ziprasidone targets ADRA2C",
"source_label": "ziprasidone",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.114",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "ziprasidone targets CHRM1",
"source_label": "ziprasidone",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "ziprasidone targets DRD1",
"source_label": "ziprasidone",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.02",
"act_comment": "Binding affinity against dopamine receptor D1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "ziprasidone targets DRD2",
"source_label": "ziprasidone",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.32",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "ziprasidone targets DRD3",
"source_label": "ziprasidone",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.14",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "ziprasidone targets DRD4",
"source_label": "ziprasidone",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "ziprasidone targets DRD5",
"source_label": "ziprasidone",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.818",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "3005",
"properties": {
"id": "ziprasidone targets H1-0",
"source_label": "ziprasidone",
"target_label": "H1-0",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.82",
"act_comment": "Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, \u00ce\u00b1A1, 5-HT2C and H1 Receptors.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "ziprasidone targets HRH1",
"source_label": "ziprasidone",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.33",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "ziprasidone targets HTR1A",
"source_label": "ziprasidone",
"target_label": "HTR1A",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.47",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "ziprasidone targets HTR1B",
"source_label": "ziprasidone",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "ziprasidone targets HTR1D",
"source_label": "ziprasidone",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "ziprasidone targets HTR1E",
"source_label": "ziprasidone",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "ziprasidone targets HTR2A",
"source_label": "ziprasidone",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "ziprasidone targets HTR2B",
"source_label": "ziprasidone",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.565",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "ziprasidone targets HTR2C",
"source_label": "ziprasidone",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.89",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "ziprasidone targets HTR3A",
"source_label": "ziprasidone",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "ziprasidone targets HTR5A",
"source_label": "ziprasidone",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.536",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "ziprasidone targets HTR6",
"source_label": "ziprasidone",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.22",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "ziprasidone targets HTR7",
"source_label": "ziprasidone",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "ziprasidone targets KCNH2",
"source_label": "ziprasidone",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60854",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "ziprasidone targets SLC6A4",
"source_label": "ziprasidone",
"target_label": "SLC6A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:92400",
"relation": "IDG (Drug Target)",
"target": "1636",
"properties": {
"id": "zofenopril targets ACE",
"source_label": "zofenopril",
"target_label": "ACE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "Inhibitory activity against angiotensin I converting enzyme (ACE)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68740",
"relation": "IDG (Drug Target)",
"target": "11119",
"properties": {
"id": "zoledronic acid targets BTN3A1",
"source_label": "zoledronic acid",
"target_label": "BTN3A1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.31",
"act_comment": "Binding affinity to butyrophilin 3A1 in human Vgamma9/Vdelta2 T-cells assessed as activation of Vgamma9/Vdelta2 T-cells by upregulation of CD69 and CD25 after 18 hrs",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68740",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "zoledronic acid targets CA12",
"source_label": "zoledronic acid",
"target_label": "CA12",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68740",
"relation": "IDG (Drug Target)",
"target": "23632",
"properties": {
"id": "zoledronic acid targets CA14",
"source_label": "zoledronic acid",
"target_label": "CA14",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.04",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68740",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "zoledronic acid targets CA2",
"source_label": "zoledronic acid",
"target_label": "CA2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.21",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68740",
"relation": "IDG (Drug Target)",
"target": "2224",
"properties": {
"id": "zoledronic acid targets FDPS",
"source_label": "zoledronic acid",
"target_label": "FDPS",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.15",
"act_comment": "Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60857",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "zolmitriptan targets HTR1A",
"source_label": "zolmitriptan",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60857",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "zolmitriptan targets HTR1B",
"source_label": "zolmitriptan",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60857",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "zolmitriptan targets HTR1D",
"source_label": "zolmitriptan",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.9",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60857",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "zolmitriptan targets HTR1E",
"source_label": "zolmitriptan",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60857",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "zolmitriptan targets HTR1F",
"source_label": "zolmitriptan",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.45",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5732",
"relation": "IDG (Drug Target)",
"target": "2554",
"properties": {
"id": "zolpidem targets GABRA1",
"source_label": "zolpidem",
"target_label": "GABRA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.68",
"act_comment": "Assay using recombinant GABAA channels with subunit composition; α1β3γ2.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5732",
"relation": "IDG (Drug Target)",
"target": "2555",
"properties": {
"id": "zolpidem targets GABRA2",
"source_label": "zolpidem",
"target_label": "GABRA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "Displacement of [3H]Ro-151788 from benzodiazepine binding site of GABAA alpha-2-beta-2-gamma-2 receptor expressed in HEK293T cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5732",
"relation": "IDG (Drug Target)",
"target": "2556",
"properties": {
"id": "zolpidem targets GABRA3",
"source_label": "zolpidem",
"target_label": "GABRA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Displacement of [3H]Ro-151788 from benzodiazepine binding site of GABAA alpha-3-beta-2-gamma-2 receptor expressed in HEK293T cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5734",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "zonisamide targets CA1",
"source_label": "zonisamide",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.252",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5734",
"relation": "IDG (Drug Target)",
"target": "377677",
"properties": {
"id": "zonisamide targets CA13",
"source_label": "zonisamide",
"target_label": "CA13",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "Inhibition of human recombinant CA13 by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5734",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "zonisamide targets CA2",
"source_label": "zonisamide",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.99",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5734",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "zonisamide targets CA5A",
"source_label": "zonisamide",
"target_label": "CA5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Inhibition of human recombinant CA5A by CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5734",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "zonisamide targets CA6",
"source_label": "zonisamide",
"target_label": "CA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.05",
"act_comment": "Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5734",
"relation": "IDG (Drug Target)",
"target": "766",
"properties": {
"id": "zonisamide targets CA7",
"source_label": "zonisamide",
"target_label": "CA7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.93",
"act_comment": "Inhibition of human recombinant CA7 by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5734",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "zonisamide targets CA9",
"source_label": "zonisamide",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.301",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "zotepine targets ADRA1A",
"source_label": "zotepine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.155",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "zotepine targets ADRA1B",
"source_label": "zotepine",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.301",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "zotepine targets ADRA2A",
"source_label": "zotepine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.686",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "zotepine targets ADRA2B",
"source_label": "zotepine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.273",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "zotepine targets ADRA2C",
"source_label": "zotepine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.016",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "zotepine targets CHRM1",
"source_label": "zotepine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.745",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "zotepine targets CHRM2",
"source_label": "zotepine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.854",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "zotepine targets CHRM3",
"source_label": "zotepine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.137",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "zotepine targets CHRM4",
"source_label": "zotepine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "Binding affinity towards human muscarinic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "zotepine targets CHRM5",
"source_label": "zotepine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.585",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "zotepine targets DRD1",
"source_label": "zotepine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.54",
"act_comment": "Binding affinity against dopamine receptor D1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "zotepine targets DRD2",
"source_label": "zotepine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Binding affinity towards human D2 dopamine receptor.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "zotepine targets DRD3",
"source_label": "zotepine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.19",
"act_comment": "Binding affinity towards human dopamine receptor D3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "zotepine targets DRD4",
"source_label": "zotepine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.41",
"act_comment": "Binding affinity towards human dopamine-4.2 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "zotepine targets DRD5",
"source_label": "zotepine",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.606",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "zotepine targets HRH1",
"source_label": "zotepine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.21",
"act_comment": "Binding affinity towards human H1 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "zotepine targets HRH2",
"source_label": "zotepine",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.301",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "zotepine targets HTR1A",
"source_label": "zotepine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Binding affinity towards human 5-hydroxytryptamine 1 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "zotepine targets HTR1B",
"source_label": "zotepine",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "zotepine targets HTR1D",
"source_label": "zotepine",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "zotepine targets HTR1E",
"source_label": "zotepine",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "zotepine targets HTR2A",
"source_label": "zotepine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.04",
"act_comment": "Binding affinity towards human serotonin 5-hydroxytryptamine 2A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "zotepine targets HTR2C",
"source_label": "zotepine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.54",
"act_comment": "Binding affinity towards human serotonin 5-hydroxytryptamine 2C receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "zotepine targets HTR3A",
"source_label": "zotepine",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.326",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "zotepine targets HTR5A",
"source_label": "zotepine",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.538",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "zotepine targets HTR6",
"source_label": "zotepine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "zotepine targets HTR7",
"source_label": "zotepine",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "zotepine targets SLC6A2",
"source_label": "zotepine",
"target_label": "SLC6A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5736",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "zotepine targets SLC6A4",
"source_label": "zotepine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.821",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5311507",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "zuclopenthixol targets HTR6",
"source_label": "zuclopenthixol",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1.5 hrs by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9876378",
"relation": "IDG (Drug Target)",
"target": "2280",
"properties": {
"id": "zotarolimus targets FKBP1A",
"source_label": "zotarolimus",
"target_label": "FKBP1A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.55",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9876378",
"relation": "IDG (Drug Target)",
"target": "2475",
"properties": {
"id": "zotarolimus targets MTOR",
"source_label": "zotarolimus",
"target_label": "MTOR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.48",
"act_comment": "Inhibitory activity against FKBP12",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10328936",
"relation": "IDG (Drug Target)",
"target": "6869",
"properties": {
"id": "eledoisin targets TACR1",
"source_label": "eledoisin",
"target_label": "TACR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:10328936",
"relation": "IDG (Drug Target)",
"target": "6870",
"properties": {
"id": "eledoisin targets TACR3",
"source_label": "eledoisin",
"target_label": "TACR3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.66",
"act_comment": "Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:638793",
"relation": "IDG (Drug Target)",
"target": "2798",
"properties": {
"id": "gonadorelin targets GNRHR",
"source_label": "gonadorelin",
"target_label": "GNRHR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "The Compound was tested for the concentration to inhibit 50% of [125 I ]leuprorelin binding to the cloned human Leutinizing releasing hormone receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5361",
"relation": "IDG (Drug Target)",
"target": "5032",
"properties": {
"id": "suramin targets P2RY11",
"source_label": "suramin",
"target_label": "P2RY11",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5361",
"relation": "IDG (Drug Target)",
"target": "23411",
"properties": {
"id": "suramin targets SIRT1",
"source_label": "suramin",
"target_label": "SIRT1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16133851",
"relation": "IDG (Drug Target)",
"target": "2798",
"properties": {
"id": "triptorelin targets GNRHR",
"source_label": "triptorelin",
"target_label": "GNRHR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.025",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:16220016",
"relation": "IDG (Drug Target)",
"target": "799",
"properties": {
"id": "calcitonin (salmon synthetic) targets CALCR",
"source_label": "calcitonin (salmon synthetic)",
"target_label": "CALCR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "11.086",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:16132283",
"relation": "IDG (Drug Target)",
"target": "2642",
"properties": {
"id": "glucagon targets GCGR",
"source_label": "glucagon",
"target_label": "GCGR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:16132283",
"relation": "IDG (Drug Target)",
"target": "2740",
"properties": {
"id": "glucagon targets GLP1R",
"source_label": "glucagon",
"target_label": "GLP1R",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:16129706",
"relation": "IDG (Drug Target)",
"target": "6751",
"properties": {
"id": "somatostatin targets SSTR1",
"source_label": "somatostatin",
"target_label": "SSTR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.54",
"act_comment": "Inhibition of [125 I -Tyr]SRIF-14 binding to membranes isolated from CHO-K1 cells expressing cloned human SRIF receptor (sst-1) subtype",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16129706",
"relation": "IDG (Drug Target)",
"target": "6752",
"properties": {
"id": "somatostatin targets SSTR2",
"source_label": "somatostatin",
"target_label": "SSTR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.46",
"act_comment": "Inhibition of [125 I -Tyr]SRIF-14 binding to membranes isolated from CHO-K1 cells expressing cloned human SRIF receptor (sst-2) subtype",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16129706",
"relation": "IDG (Drug Target)",
"target": "6753",
"properties": {
"id": "somatostatin targets SSTR3",
"source_label": "somatostatin",
"target_label": "SSTR3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.0",
"act_comment": "Inhibition of [125 I -Tyr]SRIF-14 binding to membranes isolated from CHO-K1 cells expressing cloned human SRIF receptor (sst-3) subtype",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16129706",
"relation": "IDG (Drug Target)",
"target": "6754",
"properties": {
"id": "somatostatin targets SSTR4",
"source_label": "somatostatin",
"target_label": "SSTR4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.23",
"act_comment": "Inhibition of human sst4 receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16129706",
"relation": "IDG (Drug Target)",
"target": "6755",
"properties": {
"id": "somatostatin targets SSTR5",
"source_label": "somatostatin",
"target_label": "SSTR5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.85",
"act_comment": "Inhibition of human sst5 receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311010",
"relation": "IDG (Drug Target)",
"target": "552",
"properties": {
"id": "atosiban targets AVPR1A",
"source_label": "atosiban",
"target_label": "AVPR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.82",
"act_comment": "Binding affinity to human vasopressin V1a receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311010",
"relation": "IDG (Drug Target)",
"target": "553",
"properties": {
"id": "atosiban targets AVPR1B",
"source_label": "atosiban",
"target_label": "AVPR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.36",
"act_comment": "Binding affinity to human vasopressin V1b receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311010",
"relation": "IDG (Drug Target)",
"target": "554",
"properties": {
"id": "atosiban targets AVPR2",
"source_label": "atosiban",
"target_label": "AVPR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Binding affinity to human vasopressin V2 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311010",
"relation": "IDG (Drug Target)",
"target": "5021",
"properties": {
"id": "atosiban targets OXTR",
"source_label": "atosiban",
"target_label": "OXTR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Binding affinity to human oxytocin receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2335",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "benzethonium targets ADRA2B",
"source_label": "benzethonium",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.532",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2335",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "benzethonium targets ADRA2C",
"source_label": "benzethonium",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.545",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2335",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "benzethonium targets CHRM1",
"source_label": "benzethonium",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.004",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2335",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "benzethonium targets CHRM2",
"source_label": "benzethonium",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.69",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2335",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "benzethonium targets CHRM3",
"source_label": "benzethonium",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.092",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2335",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "benzethonium targets CHRM4",
"source_label": "benzethonium",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.444",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2335",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "benzethonium targets CHRM5",
"source_label": "benzethonium",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.018",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2335",
"relation": "IDG (Drug Target)",
"target": "2534",
"properties": {
"id": "benzethonium targets FYN",
"source_label": "benzethonium",
"target_label": "FYN",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.115",
"act_comment": "DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr))",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2335",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "benzethonium targets HTR2A",
"source_label": "benzethonium",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.432",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2335",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "benzethonium targets HTR2C",
"source_label": "benzethonium",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.269",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2335",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "benzethonium targets KCNH2",
"source_label": "benzethonium",
"target_label": "KCNH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.051",
"act_comment": "DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2335",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "benzethonium targets SLC6A2",
"source_label": "benzethonium",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.046",
"act_comment": "DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2335",
"relation": "IDG (Drug Target)",
"target": "6865",
"properties": {
"id": "benzethonium targets TACR2",
"source_label": "benzethonium",
"target_label": "TACR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.192",
"act_comment": "DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2355",
"relation": "IDG (Drug Target)",
"target": "1543",
"properties": {
"id": "bergapten targets CYP1A1",
"source_label": "bergapten",
"target_label": "CYP1A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.22",
"act_comment": "Inhibition of human recombinant CYP1A1 expressed in HEK293 cells using 7-ethoxyresorufin substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by fluorescence assay relative to control",
"act_source": "CHEMBL"
}
},
{
"source": "CID:72064",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "bietamiverine targets CHRM1",
"source_label": "bietamiverine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Displacement of [3H] N-methylscopolamine from human muscarinic M1 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:72064",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "bietamiverine targets CHRM3",
"source_label": "bietamiverine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.73",
"act_comment": "Displacement of [3H] N-methylscopolamine from human muscarinic M3 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2406",
"relation": "IDG (Drug Target)",
"target": "135",
"properties": {
"id": "bithionol targets ADORA2A",
"source_label": "bithionol",
"target_label": "ADORA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.184",
"act_comment": "DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2406",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "bithionol targets ADORA3",
"source_label": "bithionol",
"target_label": "ADORA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2406",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "bithionol targets ADRA2B",
"source_label": "bithionol",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.252",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2406",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "bithionol targets ADRA2C",
"source_label": "bithionol",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.195",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2406",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "bithionol targets EGFR",
"source_label": "bithionol",
"target_label": "EGFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.212",
"act_comment": "DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr))",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2406",
"relation": "IDG (Drug Target)",
"target": "5594",
"properties": {
"id": "bithionol targets MAPK1",
"source_label": "bithionol",
"target_label": "MAPK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.415",
"act_comment": "DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:2406",
"relation": "IDG (Drug Target)",
"target": "1432",
"properties": {
"id": "bithionol targets MAPK14",
"source_label": "bithionol",
"target_label": "MAPK14",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.498",
"act_comment": "DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:1548942",
"relation": "IDG (Drug Target)",
"target": "7442",
"properties": {
"id": "capsaicin targets TRPV1",
"source_label": "capsaicin",
"target_label": "TRPV1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "Binding affinity to human recombinant TRPV1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:688145",
"relation": "IDG (Drug Target)",
"target": "340024",
"properties": {
"id": "cinromide targets SLC6A19",
"source_label": "cinromide",
"target_label": "SLC6A19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11974",
"relation": "IDG (Drug Target)",
"target": "2147",
"properties": {
"id": "dibrompropamidine targets F2",
"source_label": "dibrompropamidine",
"target_label": "F2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "compound was tested for inhibitory activity against Thrombin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11974",
"relation": "IDG (Drug Target)",
"target": "6768",
"properties": {
"id": "dibrompropamidine targets ST14",
"source_label": "dibrompropamidine",
"target_label": "ST14",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.27",
"act_comment": "compound was tested for inhibitory activity against Matriptase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5312138",
"relation": "IDG (Drug Target)",
"target": "6915",
"properties": {
"id": "domitroban targets TBXA2R",
"source_label": "domitroban",
"target_label": "TBXA2R",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:10114",
"relation": "IDG (Drug Target)",
"target": "3290",
"properties": {
"id": "enoxolone targets HSD11B1",
"source_label": "enoxolone",
"target_label": "HSD11B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.07",
"act_comment": "Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10114",
"relation": "IDG (Drug Target)",
"target": "3291",
"properties": {
"id": "enoxolone targets HSD11B2",
"source_label": "enoxolone",
"target_label": "HSD11B2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.91",
"act_comment": "Inhibition of human 11beta-HSD2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10114",
"relation": "IDG (Drug Target)",
"target": "5583",
"properties": {
"id": "enoxolone targets PRKCH",
"source_label": "enoxolone",
"target_label": "PRKCH",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Binding affinity to recombinant human PKCeta in after 2 hrs by microequilibrium dialysis assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65719",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "eseridine targets ACHE",
"source_label": "eseridine",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "Ex vivo inhibition of human erythrocyte Acetylcholinesterase.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65719",
"relation": "IDG (Drug Target)",
"target": "590",
"properties": {
"id": "eseridine targets BCHE",
"source_label": "eseridine",
"target_label": "BCHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Ex vivo inhibition of human plasma Butyrylcholinesterase.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5756",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "estriol targets ESR1",
"source_label": "estriol",
"target_label": "ESR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.67",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5756",
"relation": "IDG (Drug Target)",
"target": "2100",
"properties": {
"id": "estriol targets ESR2",
"source_label": "estriol",
"target_label": "ESR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5756",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "estriol targets SHBG",
"source_label": "estriol",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.63",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5870",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "estrone targets ESR1",
"source_label": "estrone",
"target_label": "ESR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.15",
"act_comment": "Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor alpha.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5870",
"relation": "IDG (Drug Target)",
"target": "2100",
"properties": {
"id": "estrone targets ESR2",
"source_label": "estrone",
"target_label": "ESR2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.68",
"act_comment": "Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor beta.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5870",
"relation": "IDG (Drug Target)",
"target": "3292",
"properties": {
"id": "estrone targets HSD17B1",
"source_label": "estrone",
"target_label": "HSD17B1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "Inhibition of 17beta-HSD1 assessed as conversion of [14C]estradiol to [14C]estrone using NADP+",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5870",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "estrone targets SHBG",
"source_label": "estrone",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.18",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10255",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "kainic acid targets ADORA3",
"source_label": "kainic acid",
"target_label": "ADORA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.11",
"act_comment": "Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10255",
"relation": "IDG (Drug Target)",
"target": "2897",
"properties": {
"id": "kainic acid targets GRIK1",
"source_label": "kainic acid",
"target_label": "GRIK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.75",
"act_comment": "Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10255",
"relation": "IDG (Drug Target)",
"target": "2898",
"properties": {
"id": "kainic acid targets GRIK2",
"source_label": "kainic acid",
"target_label": "GRIK2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.49",
"act_comment": "Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]kainate as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10255",
"relation": "IDG (Drug Target)",
"target": "2899",
"properties": {
"id": "kainic acid targets GRIK3",
"source_label": "kainic acid",
"target_label": "GRIK3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Ability to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10255",
"relation": "IDG (Drug Target)",
"target": "2901",
"properties": {
"id": "kainic acid targets GRIK5",
"source_label": "kainic acid",
"target_label": "GRIK5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "Ability to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3315",
"relation": "IDG (Drug Target)",
"target": "5168",
"properties": {
"id": "evans blue targets ENPP2",
"source_label": "evans blue",
"target_label": "ENPP2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.08",
"act_comment": "Competitive inhibition of human recombinant C-terminal FLAG-tagged autotaxin expressed in baculovirus-infected Sf9 cells assessed as FS-3 hydrolysis by Michaelis-Menten method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71899",
"relation": "IDG (Drug Target)",
"target": "11188",
"properties": {
"id": "fenoxazoline targets NISCH",
"source_label": "fenoxazoline",
"target_label": "NISCH",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:20906",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "flusalan targets OPRK1",
"source_label": "flusalan",
"target_label": "OPRK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "Ability to induce 50% of maximal effect in rabbit vas deferens expressing Opioid receptor kappa 1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6917655",
"relation": "IDG (Drug Target)",
"target": "10988",
"properties": {
"id": "fumagillin targets METAP2",
"source_label": "fumagillin",
"target_label": "METAP2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.2",
"act_comment": "Inhibitory activity against Methionine aminopeptidase 2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3447",
"relation": "IDG (Drug Target)",
"target": "2147",
"properties": {
"id": "gabexate targets F2",
"source_label": "gabexate",
"target_label": "F2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-pNA-HCl as substrate measured for 5 mins by spectrophotometric assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3447",
"relation": "IDG (Drug Target)",
"target": "3249",
"properties": {
"id": "gabexate targets HPN",
"source_label": "gabexate",
"target_label": "HPN",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Boc-QRR-AMC as substrate after 15 mins by automated fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3447",
"relation": "IDG (Drug Target)",
"target": "5328",
"properties": {
"id": "gabexate targets PLAU",
"source_label": "gabexate",
"target_label": "PLAU",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "Inhibition of human uPA using pyro-Glu-Gly-Arg-pNA as substrate assessed as para-nitroaniline release from substrate measured for 5 mins by spectrophotometric assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3447",
"relation": "IDG (Drug Target)",
"target": "6582",
"properties": {
"id": "gabexate targets SLC22A2",
"source_label": "gabexate",
"target_label": "SLC22A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3447",
"relation": "IDG (Drug Target)",
"target": "55244",
"properties": {
"id": "gabexate targets SLC47A1",
"source_label": "gabexate",
"target_label": "SLC47A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3447",
"relation": "IDG (Drug Target)",
"target": "7177",
"properties": {
"id": "gabexate targets TPSAB1",
"source_label": "gabexate",
"target_label": "TPSAB1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.47",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:65130",
"relation": "IDG (Drug Target)",
"target": "2147",
"properties": {
"id": "hexamidine targets F2",
"source_label": "hexamidine",
"target_label": "F2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.65",
"act_comment": "compound was tested for inhibitory activity against Thrombin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65130",
"relation": "IDG (Drug Target)",
"target": "6768",
"properties": {
"id": "hexamidine targets ST14",
"source_label": "hexamidine",
"target_label": "ST14",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "compound was tested for inhibitory activity against Matriptase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:785",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "hydroquinone targets CA2",
"source_label": "hydroquinone",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.05",
"act_comment": "Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71360",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "iloperidone targets ADRA1A",
"source_label": "iloperidone",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.44",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71360",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "iloperidone targets ADRA2A",
"source_label": "iloperidone",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.79",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71360",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "iloperidone targets ADRA2B",
"source_label": "iloperidone",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.79",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71360",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "iloperidone targets ADRA2C",
"source_label": "iloperidone",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.79",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71360",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "iloperidone targets DRD1",
"source_label": "iloperidone",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.67",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71360",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "iloperidone targets DRD2",
"source_label": "iloperidone",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.969",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71360",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "iloperidone targets DRD3",
"source_label": "iloperidone",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.15",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71360",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "iloperidone targets DRD4",
"source_label": "iloperidone",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71360",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "iloperidone targets DRD5",
"source_label": "iloperidone",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.496",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71360",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "iloperidone targets HRH1",
"source_label": "iloperidone",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.91",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71360",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "iloperidone targets HTR1A",
"source_label": "iloperidone",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.181",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71360",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "iloperidone targets HTR1B",
"source_label": "iloperidone",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.05",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71360",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "iloperidone targets HTR1D",
"source_label": "iloperidone",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.824",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71360",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "iloperidone targets HTR2A",
"source_label": "iloperidone",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.859",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71360",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "iloperidone targets HTR2C",
"source_label": "iloperidone",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.227",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71360",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "iloperidone targets HTR6",
"source_label": "iloperidone",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.37",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71360",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "iloperidone targets HTR7",
"source_label": "iloperidone",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.66",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71360",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "iloperidone targets SIGMAR1",
"source_label": "iloperidone",
"target_label": "SIGMAR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.19",
"act_comment": "Binding affinity against sigma receptor using [3H]-( +)-SKF10,047 radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3760",
"relation": "IDG (Drug Target)",
"target": "1586",
"properties": {
"id": "isoconazole targets CYP17A1",
"source_label": "isoconazole",
"target_label": "CYP17A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "In vitro inhibition of human Cytochrome P450 17A1 activity",
"act_source": "CHEMBL"
}
},
{
"source": "CID:40461270",
"relation": "IDG (Drug Target)",
"target": "51185",
"properties": {
"id": "lenalidomide targets CRBN",
"source_label": "lenalidomide",
"target_label": "CRBN",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.527",
"act_comment": "competitive titration of thalidomide with human DDB1-human CRBN (50 nM) and Cy5-thalidomide (20 nM)",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:40461270",
"relation": "IDG (Drug Target)",
"target": "7124",
"properties": {
"id": "lenalidomide targets TNF",
"source_label": "lenalidomide",
"target_label": "TNF",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.886",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5280450",
"relation": "IDG (Drug Target)",
"target": "2170",
"properties": {
"id": "linoleic acid targets FABP3",
"source_label": "linoleic acid",
"target_label": "FABP3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "Binding affinity to human FABP3 expressed in Escherichia coli BL21 (DE3) in DMPC liposomes by surface plasmon resonance analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280450",
"relation": "IDG (Drug Target)",
"target": "2167",
"properties": {
"id": "linoleic acid targets FABP4",
"source_label": "linoleic acid",
"target_label": "FABP4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP4 expressed in Escherichia coli BL21 (DE3) cells after 3 mins relative to linoleic acid",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280450",
"relation": "IDG (Drug Target)",
"target": "5465",
"properties": {
"id": "linoleic acid targets PPARA",
"source_label": "linoleic acid",
"target_label": "PPARA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.32",
"act_comment": "Binding affinity to PPAR-alpha (unknown origin) by fluorescence-based assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44564",
"relation": "IDG (Drug Target)",
"target": "2859",
"properties": {
"id": "lodoxamide targets GPR35",
"source_label": "lodoxamide",
"target_label": "GPR35",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.793",
"act_comment": "GPR35a\u00e2\u20ac\u201cbeta-arrestin-2 interaction assays performed using a CHO\u00e2\u20ac\u201cK1 cell line stably expressing human GPR35 and beta-arrestin-2",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:10633",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "mestanolone targets SHBG",
"source_label": "mestanolone",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.81",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:15020",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "mesterolone targets SHBG",
"source_label": "mesterolone",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.6",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6010",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "methyltestosterone targets AR",
"source_label": "methyltestosterone",
"target_label": "AR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.66",
"act_comment": "22Rv1 human prostate cells transfected with hAR and luciferase reporter plasmid driven by the androgen response element.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6010",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "methyltestosterone targets NR3C1",
"source_label": "methyltestosterone",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.077",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6010",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "methyltestosterone targets SHBG",
"source_label": "methyltestosterone",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.43",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4436",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "naphazoline targets ADRA2A",
"source_label": "naphazoline",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.68",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4436",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "naphazoline targets ADRA2B",
"source_label": "naphazoline",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4436",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "naphazoline targets ADRA2C",
"source_label": "naphazoline",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:4436",
"relation": "IDG (Drug Target)",
"target": "11188",
"properties": {
"id": "naphazoline targets NISCH",
"source_label": "naphazoline",
"target_label": "NISCH",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Displacement of [125I]PIC from human imidazoline receptor 1 in human platelets analyzed under norepinephrine mask of alpha 2AR",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71237",
"relation": "IDG (Drug Target)",
"target": "2224",
"properties": {
"id": "neridronic acid targets FDPS",
"source_label": "neridronic acid",
"target_label": "FDPS",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4581",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "octopamine targets HTR3A",
"source_label": "octopamine",
"target_label": "HTR3A",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.62",
"act_comment": "Activity at SER3 receptor expressed in HEK293 cells assessed as increase in calcium by calcium imaging assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:445639",
"relation": "IDG (Drug Target)",
"target": "2168",
"properties": {
"id": "oleic acid targets FABP1",
"source_label": "oleic acid",
"target_label": "FABP1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Binding affinity to L-FABP high binding affinity site by titration calorimetry method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:445639",
"relation": "IDG (Drug Target)",
"target": "2167",
"properties": {
"id": "oleic acid targets FABP4",
"source_label": "oleic acid",
"target_label": "FABP4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.73",
"act_comment": "Displacement of 1,8-ANS from aFABP by fluorescence based-assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:445639",
"relation": "IDG (Drug Target)",
"target": "2171",
"properties": {
"id": "oleic acid targets FABP5",
"source_label": "oleic acid",
"target_label": "FABP5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.61",
"act_comment": "Displacement of 1,8-ANS from eFABP by fluorescence based-assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:445639",
"relation": "IDG (Drug Target)",
"target": "5465",
"properties": {
"id": "oleic acid targets PPARA",
"source_label": "oleic acid",
"target_label": "PPARA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Inhibition of PPAR-alpha (unknown origin) by SPA assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5353853",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "oxiconazole targets ADORA3",
"source_label": "oxiconazole",
"target_label": "ADORA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.445",
"act_comment": "DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5353853",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "oxiconazole targets ADRA2C",
"source_label": "oxiconazole",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.218",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5353853",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "oxiconazole targets CHRM3",
"source_label": "oxiconazole",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.018",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5353853",
"relation": "IDG (Drug Target)",
"target": "1557",
"properties": {
"id": "oxiconazole targets CYP2C19",
"source_label": "oxiconazole",
"target_label": "CYP2C19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.398",
"act_comment": "DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5353853",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "oxiconazole targets CYP2D6",
"source_label": "oxiconazole",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5353853",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "oxiconazole targets CYP3A4",
"source_label": "oxiconazole",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.046",
"act_comment": "DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5353853",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "oxiconazole targets DRD3",
"source_label": "oxiconazole",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.169",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5353853",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "oxiconazole targets SLC6A4",
"source_label": "oxiconazole",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.372",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:5353853",
"relation": "IDG (Drug Target)",
"target": "6916",
"properties": {
"id": "oxiconazole targets TBXAS1",
"source_label": "oxiconazole",
"target_label": "TBXAS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.209",
"act_comment": "DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:4736",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "pentazocine targets OPRD1",
"source_label": "pentazocine",
"target_label": "OPRD1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.307",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4736",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "pentazocine targets OPRK1",
"source_label": "pentazocine",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.658",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4736",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "pentazocine targets OPRM1",
"source_label": "pentazocine",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.409",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4736",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "pentazocine targets SIGMAR1",
"source_label": "pentazocine",
"target_label": "SIGMAR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.76",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:10607",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "podophyllotoxin targets CYP3A4",
"source_label": "podophyllotoxin",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.222",
"act_comment": "DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:10607",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "podophyllotoxin targets NR3C1",
"source_label": "podophyllotoxin",
"target_label": "NR3C1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Inhibition of human glucocorticoid receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4883",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "practolol targets ADRB1",
"source_label": "practolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:4886",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "pramocaine targets SIGMAR1",
"source_label": "pramocaine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.292",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3052762",
"relation": "IDG (Drug Target)",
"target": "3360",
"properties": {
"id": "prucalopride targets HTR4",
"source_label": "prucalopride",
"target_label": "HTR4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.6",
"act_comment": "Binding affinity at 5HT4 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1570",
"relation": "IDG (Drug Target)",
"target": "2671",
"properties": {
"id": "pyrithione targets GFER",
"source_label": "pyrithione",
"target_label": "GFER",
"act_type": "AC50",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787]",
"act_source": "CHEMBL"
}
},
{
"source": "CID:14373",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "pyrovalerone targets SLC6A2",
"source_label": "pyrovalerone",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.71",
"act_comment": "Displacement of [125I]RTI-55 from human NET expressed in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:14373",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "pyrovalerone targets SLC6A3",
"source_label": "pyrovalerone",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "Displacement of [3H]WIN-35428 from human dopamine transporter expressed in mouse N2A cells by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "231",
"properties": {
"id": "quercetin targets AKR1B1",
"source_label": "quercetin",
"target_label": "AKR1B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.83",
"act_comment": "Inhibition of cataracted human eye lens aldose reductase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "239",
"properties": {
"id": "quercetin targets ALOX12",
"source_label": "quercetin",
"target_label": "ALOX12",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Inhibition of 12-hLO",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "240",
"properties": {
"id": "quercetin targets ALOX5",
"source_label": "quercetin",
"target_label": "ALOX5",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Inhibition of 5LOX in human PBMC by EIA assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "9212",
"properties": {
"id": "quercetin targets AURKB",
"source_label": "quercetin",
"target_label": "AURKB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "Inhibition of aurora-B (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "558",
"properties": {
"id": "quercetin targets AXL",
"source_label": "quercetin",
"target_label": "AXL",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "Inhibition of AXL (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "983",
"properties": {
"id": "quercetin targets CDK1",
"source_label": "quercetin",
"target_label": "CDK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Inhibition of CDK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "1588",
"properties": {
"id": "quercetin targets CYP19A1",
"source_label": "quercetin",
"target_label": "CYP19A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Inhibition of human placental microsome CYP19",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "1545",
"properties": {
"id": "quercetin targets CYP1B1",
"source_label": "quercetin",
"target_label": "CYP1B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.11",
"act_comment": "Inhibition of human CYP1B1 by EROD assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "quercetin targets EGFR",
"source_label": "quercetin",
"target_label": "EGFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Inhibition of EGFR",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "2147",
"properties": {
"id": "quercetin targets F2",
"source_label": "quercetin",
"target_label": "F2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.41",
"act_comment": "Inhibition of human thrombin assessed as equilibrium dissociation constant at 50 to 1000 uM by BIAcore analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "quercetin targets FLT3",
"source_label": "quercetin",
"target_label": "FLT3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.23",
"act_comment": "Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "3480",
"properties": {
"id": "quercetin targets IGF1R",
"source_label": "quercetin",
"target_label": "IGF1R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Inhibition of IGF1R (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "51447",
"properties": {
"id": "quercetin targets IP6K2",
"source_label": "quercetin",
"target_label": "IP6K2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "Inhibition of human IP6K2 using insP6 as substrate preincubated for 15 mins followed by substrate and measured after 30 mins by TR-FRET assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "quercetin targets KDR",
"source_label": "quercetin",
"target_label": "KDR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Inhibition of VEGFR2 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "4233",
"properties": {
"id": "quercetin targets MET",
"source_label": "quercetin",
"target_label": "MET",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Inhibition of wild type MET (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "50507",
"properties": {
"id": "quercetin targets NOX4",
"source_label": "quercetin",
"target_label": "NOX4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "5292",
"properties": {
"id": "quercetin targets PIM1",
"source_label": "quercetin",
"target_label": "PIM1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "Binding affinity to non phosphorylated PIM1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "6714",
"properties": {
"id": "quercetin targets SRC",
"source_label": "quercetin",
"target_label": "SRC",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Inhibition of SRC (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280343",
"relation": "IDG (Drug Target)",
"target": "7525",
"properties": {
"id": "quercetin targets YES1",
"source_label": "quercetin",
"target_label": "YES1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Inhibition of YES (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3052776",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "rasagiline targets ACHE",
"source_label": "rasagiline",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "Inhibition of human erythrocyte AChE using acetylthiocholine chloride as substrate incubated for 15 mins by Ellman's method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3052776",
"relation": "IDG (Drug Target)",
"target": "4129",
"properties": {
"id": "rasagiline targets MAOB",
"source_label": "rasagiline",
"target_label": "MAOB",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Binding affinity towards monoamine oxidase B activity was measured using a benzylamine assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:449193",
"relation": "IDG (Drug Target)",
"target": "5141",
"properties": {
"id": "roflumilast targets PDE4A",
"source_label": "roflumilast",
"target_label": "PDE4A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.46",
"act_comment": "Inhibition of human full length PDE4A4 expressed in baculovirus infected sf21 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:449193",
"relation": "IDG (Drug Target)",
"target": "5142",
"properties": {
"id": "roflumilast targets PDE4B",
"source_label": "roflumilast",
"target_label": "PDE4B",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "Inhibition of human recombinant PDE4B by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:449193",
"relation": "IDG (Drug Target)",
"target": "5144",
"properties": {
"id": "roflumilast targets PDE4D",
"source_label": "roflumilast",
"target_label": "PDE4D",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.57",
"act_comment": "Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "22848",
"properties": {
"id": "ruboxistaurin targets AAK1",
"source_label": "ruboxistaurin",
"target_label": "AAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Binding constant for AAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "55589",
"properties": {
"id": "ruboxistaurin targets BMP2K",
"source_label": "ruboxistaurin",
"target_label": "BMP2K",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "Binding constant for BIKE kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "1019",
"properties": {
"id": "ruboxistaurin targets CDK4",
"source_label": "ruboxistaurin",
"target_label": "CDK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Binding constant for CDK4-cyclinD1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "1111",
"properties": {
"id": "ruboxistaurin targets CHEK1",
"source_label": "ruboxistaurin",
"target_label": "CHEK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.27",
"act_comment": "Binding constant for CHEK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "1195",
"properties": {
"id": "ruboxistaurin targets CLK1",
"source_label": "ruboxistaurin",
"target_label": "CLK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "Binding constant for full-length CLK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "1196",
"properties": {
"id": "ruboxistaurin targets CLK2",
"source_label": "ruboxistaurin",
"target_label": "CLK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Binding constant for CLK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "1612",
"properties": {
"id": "ruboxistaurin targets DAPK1",
"source_label": "ruboxistaurin",
"target_label": "DAPK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Binding constant for DAPK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "1760",
"properties": {
"id": "ruboxistaurin targets DMPK",
"source_label": "ruboxistaurin",
"target_label": "DMPK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Binding constant for DMPK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "1859",
"properties": {
"id": "ruboxistaurin targets DYRK1A",
"source_label": "ruboxistaurin",
"target_label": "DYRK1A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Binding constant for DYRK1A kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "ruboxistaurin targets FLT3",
"source_label": "ruboxistaurin",
"target_label": "FLT3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Binding constant for FLT3(D835Y) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "6011",
"properties": {
"id": "ruboxistaurin targets GRK1",
"source_label": "ruboxistaurin",
"target_label": "GRK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Binding constant for GRK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "2868",
"properties": {
"id": "ruboxistaurin targets GRK4",
"source_label": "ruboxistaurin",
"target_label": "GRK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.23",
"act_comment": "Binding constant for GRK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "131890",
"properties": {
"id": "ruboxistaurin targets GRK7",
"source_label": "ruboxistaurin",
"target_label": "GRK7",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "Binding constant for GRK7 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "204851",
"properties": {
"id": "ruboxistaurin targets HIPK1",
"source_label": "ruboxistaurin",
"target_label": "HIPK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Binding constant for HIPK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "28996",
"properties": {
"id": "ruboxistaurin targets HIPK2",
"source_label": "ruboxistaurin",
"target_label": "HIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Binding constant for HIPK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "10114",
"properties": {
"id": "ruboxistaurin targets HIPK3",
"source_label": "ruboxistaurin",
"target_label": "HIPK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.11",
"act_comment": "Binding constant for HIPK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "22858",
"properties": {
"id": "ruboxistaurin targets CILK1",
"source_label": "ruboxistaurin",
"target_label": "CILK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding constant for ICK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "3718",
"properties": {
"id": "ruboxistaurin targets JAK3",
"source_label": "ruboxistaurin",
"target_label": "JAK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Binding constant for JAK3(Kin.Dom.2/JH1 - catalytic) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "ruboxistaurin targets KIT",
"source_label": "ruboxistaurin",
"target_label": "KIT",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Average Binding Constant for KIT; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "26524",
"properties": {
"id": "ruboxistaurin targets LATS2",
"source_label": "ruboxistaurin",
"target_label": "LATS2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Binding constant for LATS2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "6416",
"properties": {
"id": "ruboxistaurin targets MAP2K4",
"source_label": "ruboxistaurin",
"target_label": "MAP2K4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "Binding constant for MEK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "80122",
"properties": {
"id": "ruboxistaurin targets MAP3K19",
"source_label": "ruboxistaurin",
"target_label": "MAP3K19",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.32",
"act_comment": "Binding constant for YSK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "10746",
"properties": {
"id": "ruboxistaurin targets MAP3K2",
"source_label": "ruboxistaurin",
"target_label": "MAP3K2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Binding constant for MAP3K2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "4215",
"properties": {
"id": "ruboxistaurin targets MAP3K3",
"source_label": "ruboxistaurin",
"target_label": "MAP3K3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Binding constant for MAP3K3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "5871",
"properties": {
"id": "ruboxistaurin targets MAP4K2",
"source_label": "ruboxistaurin",
"target_label": "MAP4K2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Binding constant for MAP4K2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "225689",
"properties": {
"id": "ruboxistaurin targets MAPK15",
"source_label": "ruboxistaurin",
"target_label": "MAPK15",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.06",
"act_comment": "Binding constant for ERK8 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "50488",
"properties": {
"id": "ruboxistaurin targets MINK1",
"source_label": "ruboxistaurin",
"target_label": "MINK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "Binding constant for MINK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "4638",
"properties": {
"id": "ruboxistaurin targets MYLK",
"source_label": "ruboxistaurin",
"target_label": "MYLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Binding constant for MYLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "81788",
"properties": {
"id": "ruboxistaurin targets NUAK2",
"source_label": "ruboxistaurin",
"target_label": "NUAK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.49",
"act_comment": "Binding constant for SNARK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "5170",
"properties": {
"id": "ruboxistaurin targets PDPK1",
"source_label": "ruboxistaurin",
"target_label": "PDPK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Binding constant for full-length PDPK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "5292",
"properties": {
"id": "ruboxistaurin targets PIM1",
"source_label": "ruboxistaurin",
"target_label": "PIM1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Competitive binding affinity to PIM1 in presence of ATP",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "11040",
"properties": {
"id": "ruboxistaurin targets PIM2",
"source_label": "ruboxistaurin",
"target_label": "PIM2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Average Binding Constant for PIM2; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "415116",
"properties": {
"id": "ruboxistaurin targets PIM3",
"source_label": "ruboxistaurin",
"target_label": "PIM3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Binding constant for PIM3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "8396",
"properties": {
"id": "ruboxistaurin targets PIP4K2B",
"source_label": "ruboxistaurin",
"target_label": "PIP4K2B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.08",
"act_comment": "Binding constant for full-length PIP5K2B",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "8394",
"properties": {
"id": "ruboxistaurin targets PIP5K1A",
"source_label": "ruboxistaurin",
"target_label": "PIP5K1A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "Binding constant for full-length PIP5K1A",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "23396",
"properties": {
"id": "ruboxistaurin targets PIP5K1C",
"source_label": "ruboxistaurin",
"target_label": "PIP5K1C",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "Binding constant for PIP5K1C kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "5585",
"properties": {
"id": "ruboxistaurin targets PKN1",
"source_label": "ruboxistaurin",
"target_label": "PKN1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Binding constant for PKN1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "10733",
"properties": {
"id": "ruboxistaurin targets PLK4",
"source_label": "ruboxistaurin",
"target_label": "PLK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.43",
"act_comment": "Average Binding Constant for STK18; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "5578",
"properties": {
"id": "ruboxistaurin targets PRKCA",
"source_label": "ruboxistaurin",
"target_label": "PRKCA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Inhibition of Protein kinase C alpha",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "5579",
"properties": {
"id": "ruboxistaurin targets PRKCB",
"source_label": "ruboxistaurin",
"target_label": "PRKCB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.33",
"act_comment": "Inhibition of Protein kinase C beta 1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "5580",
"properties": {
"id": "ruboxistaurin targets PRKCD",
"source_label": "ruboxistaurin",
"target_label": "PRKCD",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.44",
"act_comment": "Binding constant for PRKCD kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "5581",
"properties": {
"id": "ruboxistaurin targets PRKCE",
"source_label": "ruboxistaurin",
"target_label": "PRKCE",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Binding constant for PRKCE kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "5582",
"properties": {
"id": "ruboxistaurin targets PRKCG",
"source_label": "ruboxistaurin",
"target_label": "PRKCG",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Inhibition of Protein kinase C gamma",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "5588",
"properties": {
"id": "ruboxistaurin targets PRKCQ",
"source_label": "ruboxistaurin",
"target_label": "PRKCQ",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.6",
"act_comment": "Binding constant for PRKCQ kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "25865",
"properties": {
"id": "ruboxistaurin targets PRKD2",
"source_label": "ruboxistaurin",
"target_label": "PRKD2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Binding constant for PRKD2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "83732",
"properties": {
"id": "ruboxistaurin targets RIOK1",
"source_label": "ruboxistaurin",
"target_label": "RIOK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Binding constant for full-length RIOK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "8780",
"properties": {
"id": "ruboxistaurin targets RIOK3",
"source_label": "ruboxistaurin",
"target_label": "RIOK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Binding constant for RIOK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "6195",
"properties": {
"id": "ruboxistaurin targets RPS6KA1",
"source_label": "ruboxistaurin",
"target_label": "RPS6KA1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Binding constant for RPS6KA1(Kin.Dom.1 - N-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "6196",
"properties": {
"id": "ruboxistaurin targets RPS6KA2",
"source_label": "ruboxistaurin",
"target_label": "RPS6KA2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Binding constant for RPS6KA2(Kin.Dom.1 - N-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "6198",
"properties": {
"id": "ruboxistaurin targets RPS6KB1",
"source_label": "ruboxistaurin",
"target_label": "RPS6KB1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Binding constant for S6K1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "9748",
"properties": {
"id": "ruboxistaurin targets SLK",
"source_label": "ruboxistaurin",
"target_label": "SLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Binding constant for SLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "6793",
"properties": {
"id": "ruboxistaurin targets STK10",
"source_label": "ruboxistaurin",
"target_label": "STK10",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Binding constant for LOK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "6788",
"properties": {
"id": "ruboxistaurin targets STK3",
"source_label": "ruboxistaurin",
"target_label": "STK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "Binding constant for MST2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "6789",
"properties": {
"id": "ruboxistaurin targets STK4",
"source_label": "ruboxistaurin",
"target_label": "STK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Average Binding Constant for STK4; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "51347",
"properties": {
"id": "ruboxistaurin targets TAOK3",
"source_label": "ruboxistaurin",
"target_label": "TAOK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.01",
"act_comment": "Binding constant for TAOK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:153999",
"relation": "IDG (Drug Target)",
"target": "29110",
"properties": {
"id": "ruboxistaurin targets TBK1",
"source_label": "ruboxistaurin",
"target_label": "TBK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Binding constant for TBK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:129228",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "rufinamide targets CA5A",
"source_label": "rufinamide",
"target_label": "CA5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Inhibition of recombinant human carbonic anhydrase VA preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280805",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "rutoside targets ACHE",
"source_label": "rutoside",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Inhibition of AChE (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9577995",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "sabcomeline targets CHRM1",
"source_label": "sabcomeline",
"target_label": "CHRM1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "In vitro affinity against human Muscarinic acetylcholine receptor M1 using quinuclidynyl benzylate (QNB)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9577995",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "sabcomeline targets CHRM2",
"source_label": "sabcomeline",
"target_label": "CHRM2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9577995",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "sabcomeline targets CHRM3",
"source_label": "sabcomeline",
"target_label": "CHRM3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.22",
"act_comment": "In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9577995",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "sabcomeline targets CHRM4",
"source_label": "sabcomeline",
"target_label": "CHRM4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.24",
"act_comment": "Partial agonist activity at human M4 receptor co-expressed with Galpha16 in CHO cells assessed as calcium mobilization after 60 mins by FLIPR assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9577995",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "sabcomeline targets CHRM5",
"source_label": "sabcomeline",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6324663",
"relation": "IDG (Drug Target)",
"target": "185",
"properties": {
"id": "saralasin targets AGTR1",
"source_label": "saralasin",
"target_label": "AGTR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.77",
"act_comment": "Binding affinity to human AT1 receptor by radioligand displacement assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6324663",
"relation": "IDG (Drug Target)",
"target": "186",
"properties": {
"id": "saralasin targets AGTR2",
"source_label": "saralasin",
"target_label": "AGTR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.82",
"act_comment": "Displacement of radiolabeled saralasin from human AT2 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216235",
"relation": "IDG (Drug Target)",
"target": "1909",
"properties": {
"id": "sitaxentan targets EDNRA",
"source_label": "sitaxentan",
"target_label": "EDNRA",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.37",
"act_comment": "Binding affinity against human Endothelin A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3115",
"relation": "IDG (Drug Target)",
"target": "3265",
"properties": {
"id": "stallimycin targets HRAS",
"source_label": "stallimycin",
"target_label": "HRAS",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) products",
"act_source": "CHEMBL"
}
},
{
"source": "CID:108143",
"relation": "IDG (Drug Target)",
"target": "5914",
"properties": {
"id": "tamibarotene targets RARA",
"source_label": "tamibarotene",
"target_label": "RARA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.11",
"act_comment": "Binding affinity for Retinoic Acid Receptor alpha (RAR alpha)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:108143",
"relation": "IDG (Drug Target)",
"target": "5915",
"properties": {
"id": "tamibarotene targets RARB",
"source_label": "tamibarotene",
"target_label": "RARB",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.63",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:108143",
"relation": "IDG (Drug Target)",
"target": "5916",
"properties": {
"id": "tamibarotene targets RARG",
"source_label": "tamibarotene",
"target_label": "RARG",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.23",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5401",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "terazosin targets ADRA1A",
"source_label": "terazosin",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.95",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5401",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "terazosin targets ADRA1B",
"source_label": "terazosin",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.08",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5401",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "terazosin targets ADRA1D",
"source_label": "terazosin",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5401",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "terazosin targets ADRA2A",
"source_label": "terazosin",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5401",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "terazosin targets ADRA2B",
"source_label": "terazosin",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.93",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5401",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "terazosin targets ADRA2C",
"source_label": "terazosin",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.88",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5455",
"relation": "IDG (Drug Target)",
"target": "10919",
"properties": {
"id": "thiram targets EHMT2",
"source_label": "thiram",
"target_label": "EHMT2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "Inhibition of wild type recombinant human histone lysine methyltransferase G9a (913 to 1193 residues) expressed in Escherichia coli Rosetta BL21 DE3 PlysS using ARTKQTARKSTGGKA as substrate preincubated for 5 mins followed by substrate/SAM addition measured after 60 mins by MALDI-TOF MS analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5455",
"relation": "IDG (Drug Target)",
"target": "4017",
"properties": {
"id": "thiram targets LOXL2",
"source_label": "thiram",
"target_label": "LOXL2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Inhibition of recombinant LOXL2 (unknown origin) expressed in NS0 cells using diaminopentane as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr by fluorimetric method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5455",
"relation": "IDG (Drug Target)",
"target": "84695",
"properties": {
"id": "thiram targets LOXL3",
"source_label": "thiram",
"target_label": "LOXL3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr by fluorimetric method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5455",
"relation": "IDG (Drug Target)",
"target": "84171",
"properties": {
"id": "thiram targets LOXL4",
"source_label": "thiram",
"target_label": "LOXL4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.75",
"act_comment": "Inhibition of recombinant human LOXL4 expressed in baculovirus infected insect cells using diaminopentane as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr by fluorimetric method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5455",
"relation": "IDG (Drug Target)",
"target": "11343",
"properties": {
"id": "thiram targets MGLL",
"source_label": "thiram",
"target_label": "MGLL",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Inhibition of human MGL activity using [3H]2-oleoylglycerol substrate by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5804",
"relation": "IDG (Drug Target)",
"target": "7067",
"properties": {
"id": "thyropropic acid targets THRA",
"source_label": "thyropropic acid",
"target_label": "THRA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.39",
"act_comment": "Concentration required to inhibit 50% of I-T3 binding to hTR1 (Thyroid hormone receptor alpha) was determined",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5804",
"relation": "IDG (Drug Target)",
"target": "7068",
"properties": {
"id": "thyropropic acid targets THRB",
"source_label": "thyropropic acid",
"target_label": "THRB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.72",
"act_comment": "Concentration required to inhibit 50% of I-T3 binding to hTR1 (Thyroid hormone receptor beta) was determined",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5803",
"relation": "IDG (Drug Target)",
"target": "5468",
"properties": {
"id": "tiratricol targets PPARG",
"source_label": "tiratricol",
"target_label": "PPARG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Binding affinity to recombinant PPARgamma LBD (unknown origin) by isothermal titration calorimetry",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5803",
"relation": "IDG (Drug Target)",
"target": "7067",
"properties": {
"id": "tiratricol targets THRA",
"source_label": "tiratricol",
"target_label": "THRA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.85",
"act_comment": "Concentration required to inhibit 50% of I-T3 binding to hTR1 (Thyroid hormone receptor alpha) was determined",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5803",
"relation": "IDG (Drug Target)",
"target": "7068",
"properties": {
"id": "tiratricol targets THRB",
"source_label": "tiratricol",
"target_label": "THRB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.39",
"act_comment": "Inhibition of thyroid hormone receptor beta",
"act_source": "CHEMBL"
}
},
{
"source": "CID:18047",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "toliprolol targets ADRB1",
"source_label": "toliprolol",
"target_label": "ADRB1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.42",
"act_comment": "Binding affinity to beta-1 adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:18047",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "toliprolol targets ADRB2",
"source_label": "toliprolol",
"target_label": "ADRB2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.92",
"act_comment": "Binding affinity to beta2 adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5524",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "tramazoline targets ADRA2A",
"source_label": "tramazoline",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5524",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "tramazoline targets ADRA2B",
"source_label": "tramazoline",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.86",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5524",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "tramazoline targets ADRA2C",
"source_label": "tramazoline",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.56",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:7547",
"relation": "IDG (Drug Target)",
"target": "2052",
"properties": {
"id": "triclocarban targets EPHX1",
"source_label": "triclocarban",
"target_label": "EPHX1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:7547",
"relation": "IDG (Drug Target)",
"target": "2053",
"properties": {
"id": "triclocarban targets EPHX2",
"source_label": "triclocarban",
"target_label": "EPHX2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5564",
"relation": "IDG (Drug Target)",
"target": "873",
"properties": {
"id": "triclosan targets CBR1",
"source_label": "triclosan",
"target_label": "CBR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.22",
"act_comment": "Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrate",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6133",
"relation": "IDG (Drug Target)",
"target": "5029",
"properties": {
"id": "uridine triphosphate targets P2RY2",
"source_label": "uridine triphosphate",
"target_label": "P2RY2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6133",
"relation": "IDG (Drug Target)",
"target": "5030",
"properties": {
"id": "uridine triphosphate targets P2RY4",
"source_label": "uridine triphosphate",
"target_label": "P2RY4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6918537",
"relation": "IDG (Drug Target)",
"target": "1803",
"properties": {
"id": "vildagliptin targets DPP4",
"source_label": "vildagliptin",
"target_label": "DPP4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "Inhibition of DPP4 in human plasma using Gly-Pro-AMC as substrate by fluorimetric analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918537",
"relation": "IDG (Drug Target)",
"target": "54878",
"properties": {
"id": "vildagliptin targets DPP8",
"source_label": "vildagliptin",
"target_label": "DPP8",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Inhibition of DPP8",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918537",
"relation": "IDG (Drug Target)",
"target": "91039",
"properties": {
"id": "vildagliptin targets DPP9",
"source_label": "vildagliptin",
"target_label": "DPP9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.17",
"act_comment": "Inhibition of DPP9",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918191",
"relation": "IDG (Drug Target)",
"target": "1588",
"properties": {
"id": "vorozole targets CYP19A1",
"source_label": "vorozole",
"target_label": "CYP19A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.86",
"act_comment": "Inhibition of human placental microsome CYP19",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60809",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "xanomeline targets CHRM1",
"source_label": "xanomeline",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.38",
"act_comment": "Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60809",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "xanomeline targets CHRM2",
"source_label": "xanomeline",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60809",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "xanomeline targets CHRM3",
"source_label": "xanomeline",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Displacement of [3H]-4-DAMP from human muscarinic M3 receptor expressed in BHK-21 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60809",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "xanomeline targets CHRM4",
"source_label": "xanomeline",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.14",
"act_comment": "Displacement of [3H]-4-DAMP from human muscarinic M4 receptor expressed in BHK-21 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60809",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "xanomeline targets CHRM5",
"source_label": "xanomeline",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "Displacement of [3H]-4-DAMP from human muscarinic M5 receptor expressed in BHK-21 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60809",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "xanomeline targets DRD2",
"source_label": "xanomeline",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60809",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "xanomeline targets DRD3",
"source_label": "xanomeline",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:60809",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "xanomeline targets HTR1A",
"source_label": "xanomeline",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:60809",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "xanomeline targets HTR1B",
"source_label": "xanomeline",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:60809",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "xanomeline targets HTR1D",
"source_label": "xanomeline",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:60809",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "xanomeline targets HTR1F",
"source_label": "xanomeline",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:60809",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "xanomeline targets HTR2A",
"source_label": "xanomeline",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:60809",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "xanomeline targets HTR2B",
"source_label": "xanomeline",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:60809",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "xanomeline targets HTR2C",
"source_label": "xanomeline",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:60809",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "xanomeline targets HTR7",
"source_label": "xanomeline",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5709",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "xylometazoline targets ADRA1A",
"source_label": "xylometazoline",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.04",
"act_comment": "Binding affinity towards human Alpha-1 adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5709",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "xylometazoline targets ADRA2A",
"source_label": "xylometazoline",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.82",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5709",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "xylometazoline targets ADRA2C",
"source_label": "xylometazoline",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:5709",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "xylometazoline targets HTR1B",
"source_label": "xylometazoline",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Binding affinity towards human 5-hydroxytryptamine 1B receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5709",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "xylometazoline targets HTR1D",
"source_label": "xylometazoline",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.15",
"act_comment": "Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:8969",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "yohimbine targets ADORA3",
"source_label": "yohimbine",
"target_label": "ADORA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.02",
"act_comment": "Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:8969",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "yohimbine targets ADRA1A",
"source_label": "yohimbine",
"target_label": "ADRA1A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Inhibition of specific [3H]prazosin binding (0.2 nM) to rat brain membranes alpha-1 adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:8969",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "yohimbine targets ADRA1B",
"source_label": "yohimbine",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.96",
"act_comment": "Binding affinity against Alpha-1B adrenergic receptor from hamster clones.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:8969",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "yohimbine targets ADRA1D",
"source_label": "yohimbine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "Binding affinity against Alpha-1D adrenergic receptor, from human clones.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:8969",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "yohimbine targets ADRA2A",
"source_label": "yohimbine",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.38",
"act_comment": "Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:8969",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "yohimbine targets ADRA2B",
"source_label": "yohimbine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand",
"act_source": "CHEMBL"
}
},
{
"source": "CID:8969",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "yohimbine targets ADRA2C",
"source_label": "yohimbine",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "Displacement of [3H]RX821002 from human recombinant alpha2C adrenoceptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:8969",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "yohimbine targets DRD2",
"source_label": "yohimbine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.163",
"act_comment": "DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:8969",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "yohimbine targets HTR1A",
"source_label": "yohimbine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:8969",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "yohimbine targets HTR1B",
"source_label": "yohimbine",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:8969",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "yohimbine targets HTR1D",
"source_label": "yohimbine",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:8969",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "yohimbine targets HTR1F",
"source_label": "yohimbine",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:8969",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "yohimbine targets HTR2B",
"source_label": "yohimbine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:8969",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "yohimbine targets HTR6",
"source_label": "yohimbine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.106",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:15723",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "azacyclonol targets HRH1",
"source_label": "azacyclonol",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.18",
"act_comment": "Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO cell by Betaplate scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2755709",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "benzylsulfamide targets CA1",
"source_label": "benzylsulfamide",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.93",
"act_comment": "Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2755709",
"relation": "IDG (Drug Target)",
"target": "771",
"properties": {
"id": "benzylsulfamide targets CA12",
"source_label": "benzylsulfamide",
"target_label": "CA12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2755709",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "benzylsulfamide targets CA2",
"source_label": "benzylsulfamide",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.67",
"act_comment": "Inhibition of human carbonic anhydrase 2-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:2755709",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "benzylsulfamide targets CA9",
"source_label": "benzylsulfamide",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.66",
"act_comment": "Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped-flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65457",
"relation": "IDG (Drug Target)",
"target": "7498",
"properties": {
"id": "bropirimine targets XDH",
"source_label": "bropirimine",
"target_label": "XDH",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Inhibition of C-terminally FLAG-tagged human xanthine oxidase (amino acid 1 to 1333) expressed in baculovirus system after 15 mins by spectrophotometry",
"act_source": "CHEMBL"
}
},
{
"source": "CID:60919",
"relation": "IDG (Drug Target)",
"target": "185",
"properties": {
"id": "tasosartan targets AGTR1",
"source_label": "tasosartan",
"target_label": "AGTR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.49",
"act_comment": "Compound was tested for inhibition against Angiotensin II receptor, type 1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3655",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "velnacrine targets ACHE",
"source_label": "velnacrine",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.79",
"act_comment": "Inhibition of acetylcholinesterase (AChE) of human red blood cell (type XIII) by modified radiometric AChE assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:39912",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "dexibuprofen targets PTGS1",
"source_label": "dexibuprofen",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.01",
"act_comment": "Inhibition of COX1 in human HEL 92.1.7 cells assessed as thromboxane B2 production incubated for 30 mins before arachidonic acid addition measured after 15 mins by ELISA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:39912",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "dexibuprofen targets PTGS2",
"source_label": "dexibuprofen",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Inhibition of COX2 in LPS-stimulated and PMA-treated human U937 cells assessed as PGE2 production after 15 mins by ELISA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:449171",
"relation": "IDG (Drug Target)",
"target": "3164",
"properties": {
"id": "alitretinoin targets NR4A1",
"source_label": "alitretinoin",
"target_label": "NR4A1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Binding affinity to Nur77 Y453A mutant expressed in human BGC823 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:449171",
"relation": "IDG (Drug Target)",
"target": "5914",
"properties": {
"id": "alitretinoin targets RARA",
"source_label": "alitretinoin",
"target_label": "RARA",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:449171",
"relation": "IDG (Drug Target)",
"target": "5915",
"properties": {
"id": "alitretinoin targets RARB",
"source_label": "alitretinoin",
"target_label": "RARB",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:449171",
"relation": "IDG (Drug Target)",
"target": "5916",
"properties": {
"id": "alitretinoin targets RARG",
"source_label": "alitretinoin",
"target_label": "RARG",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.13",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:449171",
"relation": "IDG (Drug Target)",
"target": "6256",
"properties": {
"id": "alitretinoin targets RXRA",
"source_label": "alitretinoin",
"target_label": "RXRA",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:449171",
"relation": "IDG (Drug Target)",
"target": "6257",
"properties": {
"id": "alitretinoin targets RXRB",
"source_label": "alitretinoin",
"target_label": "RXRB",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:449171",
"relation": "IDG (Drug Target)",
"target": "6258",
"properties": {
"id": "alitretinoin targets RXRG",
"source_label": "alitretinoin",
"target_label": "RXRG",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:91522200",
"relation": "IDG (Drug Target)",
"target": "8912",
"properties": {
"id": "benidipine targets CACNA1H",
"source_label": "benidipine",
"target_label": "CACNA1H",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.843",
"act_comment": "HEK-293 cells stably expressing hCav3.2 T-type Ca2+ channels",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:68663",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "biriperone targets DRD3",
"source_label": "biriperone",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Ability to compete with [3H]YM-09151-2 binding to the human dopamine receptor D3 transfected in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1238",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "clorotepine targets DRD2",
"source_label": "clorotepine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.17",
"act_comment": "Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1238",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "clorotepine targets DRD3",
"source_label": "clorotepine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.372",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:1238",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "clorotepine targets DRD4",
"source_label": "clorotepine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.398",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:1238",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "clorotepine targets HRH1",
"source_label": "clorotepine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.72",
"act_comment": "Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1238",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "clorotepine targets HTR2C",
"source_label": "clorotepine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.24",
"act_comment": "Displacement of [3H]prozosin from human cloned 5HT2C receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1238",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "clorotepine targets HTR6",
"source_label": "clorotepine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.665",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:9400",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "dexamethasone phosphate targets NR3C1",
"source_label": "dexamethasone phosphate",
"target_label": "NR3C1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 24 hrs",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9400",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "dexamethasone phosphate targets NR3C2",
"source_label": "dexamethasone phosphate",
"target_label": "NR3C2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.44",
"act_comment": "Displacement of [3H]-aldosterone from human mineralocorticoid receptor expressed in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9400",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "dexamethasone phosphate targets PGR",
"source_label": "dexamethasone phosphate",
"target_label": "PGR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "Displacement of [3H]-methyltrienolone from human progesterone receptor expressed in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10635",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "androstanolone targets AR",
"source_label": "androstanolone",
"target_label": "AR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "Displacement of [3H]DHT from human androgen receptor expressed in MDA-MB-453 cells by whole cell receptor binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10635",
"relation": "IDG (Drug Target)",
"target": "1588",
"properties": {
"id": "androstanolone targets CYP19A1",
"source_label": "androstanolone",
"target_label": "CYP19A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Competitive inhibition of binding to human placental Cytochrome P450 19A1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10635",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "androstanolone targets NR3C1",
"source_label": "androstanolone",
"target_label": "NR3C1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.27",
"act_comment": "Binding affinity to GR (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10635",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "androstanolone targets NR3C2",
"source_label": "androstanolone",
"target_label": "NR3C2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Binding affinity to MR (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10635",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "androstanolone targets SHBG",
"source_label": "androstanolone",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.74",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3033818",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "dolasetron targets HTR3A",
"source_label": "dolasetron",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.698",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:3517",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "guanabenz targets ADRA1D",
"source_label": "guanabenz",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.801",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3517",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "guanabenz targets ADRA2A",
"source_label": "guanabenz",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.824",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3517",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "guanabenz targets ADRA2B",
"source_label": "guanabenz",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.167",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3517",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "guanabenz targets ADRA2C",
"source_label": "guanabenz",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.793",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3517",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "guanabenz targets HTR2A",
"source_label": "guanabenz",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.951",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3517",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "guanabenz targets HTR2B",
"source_label": "guanabenz",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.208",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3517",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "guanabenz targets HTR2C",
"source_label": "guanabenz",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.971",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3517",
"relation": "IDG (Drug Target)",
"target": "11188",
"properties": {
"id": "guanabenz targets NISCH",
"source_label": "guanabenz",
"target_label": "NISCH",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.46",
"act_comment": "Displacement of [125I]PIC from human imidazoline receptor 1 in human platelets analyzed under norepinephrine mask of alpha 2AR",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3517",
"relation": "IDG (Drug Target)",
"target": "134864",
"properties": {
"id": "guanabenz targets TAAR1",
"source_label": "guanabenz",
"target_label": "TAAR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.05",
"act_comment": "Agonist activity at human TAAR1 receptor expressed in HEK293T cells cotransfected with beta-2 receptor assessed as cAMP production by BRET assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:119369",
"relation": "IDG (Drug Target)",
"target": "552",
"properties": {
"id": "mozavaptan targets AVPR1A",
"source_label": "mozavaptan",
"target_label": "AVPR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.71",
"act_comment": "Binding affinity to vasopressin V1a receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:119369",
"relation": "IDG (Drug Target)",
"target": "554",
"properties": {
"id": "mozavaptan targets AVPR2",
"source_label": "mozavaptan",
"target_label": "AVPR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.03",
"act_comment": "Concentration which inhibit [3H]AVP binding to human Vasopressin V2 receptor coded HeLa cells by 50%",
"act_source": "CHEMBL"
}
},
{
"source": "CID:119369",
"relation": "IDG (Drug Target)",
"target": "5021",
"properties": {
"id": "mozavaptan targets OXTR",
"source_label": "mozavaptan",
"target_label": "OXTR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.18",
"act_comment": "Binding affinity to oxytocin receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:439280",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "oxitriptan targets HTR1A",
"source_label": "oxitriptan",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.04",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:439280",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "oxitriptan targets HTR2A",
"source_label": "oxitriptan",
"target_label": "HTR2A",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:439280",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "oxitriptan targets HTR2B",
"source_label": "oxitriptan",
"target_label": "HTR2B",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:439280",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "oxitriptan targets HTR2C",
"source_label": "oxitriptan",
"target_label": "HTR2C",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.74",
"act_comment": "Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:439280",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "oxitriptan targets HTR7",
"source_label": "oxitriptan",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.67",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:168613",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "timolol targets ADRB1",
"source_label": "timolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:168613",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "timolol targets ADRB2",
"source_label": "timolol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:168613",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "timolol targets ADRB3",
"source_label": "timolol",
"target_label": "ADRB3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:104903",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "tirilazad targets HTR2A",
"source_label": "tirilazad",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.243",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:104903",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "tirilazad targets HTR2C",
"source_label": "tirilazad",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.425",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:130956",
"relation": "IDG (Drug Target)",
"target": "2224",
"properties": {
"id": "minodronic acid targets FDPS",
"source_label": "minodronic acid",
"target_label": "FDPS",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16078",
"relation": "IDG (Drug Target)",
"target": "1268",
"properties": {
"id": "dronabinol targets CNR1",
"source_label": "dronabinol",
"target_label": "CNR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.54",
"act_comment": "Displacement of [3H]CP-55940 from human CB1 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16078",
"relation": "IDG (Drug Target)",
"target": "1269",
"properties": {
"id": "dronabinol targets CNR2",
"source_label": "dronabinol",
"target_label": "CNR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.48",
"act_comment": "Binding affinity to human CB2 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16078",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "dronabinol targets DRD3",
"source_label": "dronabinol",
"target_label": "DRD3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.99",
"act_comment": "Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16078",
"relation": "IDG (Drug Target)",
"target": "2841",
"properties": {
"id": "dronabinol targets GPR18",
"source_label": "dronabinol",
"target_label": "GPR18",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "Agonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:216237",
"relation": "IDG (Drug Target)",
"target": "552",
"properties": {
"id": "tolvaptan targets AVPR1A",
"source_label": "tolvaptan",
"target_label": "AVPR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:216237",
"relation": "IDG (Drug Target)",
"target": "554",
"properties": {
"id": "tolvaptan targets AVPR2",
"source_label": "tolvaptan",
"target_label": "AVPR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:208898",
"relation": "IDG (Drug Target)",
"target": "786",
"properties": {
"id": "dronedarone targets CACNG1",
"source_label": "dronedarone",
"target_label": "CACNG1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.699",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:208898",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "dronedarone targets KCNH2",
"source_label": "dronedarone",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "Inhibition of human ERG",
"act_source": "CHEMBL"
}
},
{
"source": "CID:208898",
"relation": "IDG (Drug Target)",
"target": "3785",
"properties": {
"id": "dronedarone targets KCNQ2",
"source_label": "dronedarone",
"target_label": "KCNQ2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:11243969",
"relation": "IDG (Drug Target)",
"target": "1803",
"properties": {
"id": "saxagliptin targets DPP4",
"source_label": "saxagliptin",
"target_label": "DPP4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.22",
"act_comment": "Inhibition of human DPP4 expressed in Caco-2 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11243969",
"relation": "IDG (Drug Target)",
"target": "54878",
"properties": {
"id": "saxagliptin targets DPP8",
"source_label": "saxagliptin",
"target_label": "DPP8",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Inhibition of DPP8",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11243969",
"relation": "IDG (Drug Target)",
"target": "91039",
"properties": {
"id": "saxagliptin targets DPP9",
"source_label": "saxagliptin",
"target_label": "DPP9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "Inhibition of DPP9",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9903970",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "asenapine targets ADRA1A",
"source_label": "asenapine",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.92",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9903970",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "asenapine targets ADRA2B",
"source_label": "asenapine",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.73",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9903970",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "asenapine targets DRD1",
"source_label": "asenapine",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9903970",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "asenapine targets DRD2",
"source_label": "asenapine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.75",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9903970",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "asenapine targets DRD3",
"source_label": "asenapine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.06",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9903970",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "asenapine targets DRD4",
"source_label": "asenapine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.71",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9903970",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "asenapine targets HRH1",
"source_label": "asenapine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9903970",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "asenapine targets HRH2",
"source_label": "asenapine",
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"act_type": "IC50",
"act_relation": "=",
"act_value": "8.21",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9903970",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "asenapine targets HTR1A",
"source_label": "asenapine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.97",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9903970",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "asenapine targets HTR1B",
"source_label": "asenapine",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9903970",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "asenapine targets HTR1D",
"source_label": "asenapine",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9903970",
"relation": "IDG (Drug Target)",
"target": "3354",
"properties": {
"id": "asenapine targets HTR1E",
"source_label": "asenapine",
"target_label": "HTR1E",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9903970",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "asenapine targets HTR2A",
"source_label": "asenapine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.61",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9903970",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "asenapine targets HTR2B",
"source_label": "asenapine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.8",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9903970",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "asenapine targets HTR2C",
"source_label": "asenapine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.93",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9903970",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "asenapine targets HTR5A",
"source_label": "asenapine",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.6",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9903970",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "asenapine targets HTR6",
"source_label": "asenapine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.22",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9903970",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "asenapine targets HTR7",
"source_label": "asenapine",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.47",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:148121",
"relation": "IDG (Drug Target)",
"target": "1719",
"properties": {
"id": "pralatrexate targets DHFR",
"source_label": "pralatrexate",
"target_label": "DHFR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.35",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:148121",
"relation": "IDG (Drug Target)",
"target": "2348",
"properties": {
"id": "pralatrexate targets FOLR1",
"source_label": "pralatrexate",
"target_label": "FOLR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.78",
"act_comment": "Binding affinity to human FR-alpha receptor expressed in Chinese hamster RT16 cells assessed as antiproliferative activity measured as reduction in cell viability after 96 hrs by Cell-Titer Blue assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:148121",
"relation": "IDG (Drug Target)",
"target": "6573",
"properties": {
"id": "pralatrexate targets SLC19A1",
"source_label": "pralatrexate",
"target_label": "SLC19A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.16",
"act_comment": "Binding affinity to human RFC expressed in Chinese hamster PC43-10 cells assessed as antiproliferative activity measured as reduction in cell viability after 96 hrs by Cell-Titer Blue assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:148121",
"relation": "IDG (Drug Target)",
"target": "113235",
"properties": {
"id": "pralatrexate targets SLC46A1",
"source_label": "pralatrexate",
"target_label": "SLC46A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.24",
"act_comment": "Binding affinity to human PCFT expressed in Chinese hamster R2/PCFT4 cells assessed as antiproliferative activity measured as reduction in cell viability after 96 hrs by Cell-Titer Blue assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "pazopanib targets ABL1",
"source_label": "pazopanib",
"target_label": "ABL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Binding constant for ABL1(H396P)-non phosphorylated kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "pazopanib targets ACHE",
"source_label": "pazopanib",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "Inhibition of AChE (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "6795",
"properties": {
"id": "pazopanib targets AURKC",
"source_label": "pazopanib",
"target_label": "AURKC",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Binding constant for full-length AURKC",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "658",
"properties": {
"id": "pazopanib targets BMPR1B",
"source_label": "pazopanib",
"target_label": "BMPR1B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for BMPR1B kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "673",
"properties": {
"id": "pazopanib targets BRAF",
"source_label": "pazopanib",
"target_label": "BRAF",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "Binding constant for BRAF(V600E) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "1436",
"properties": {
"id": "pazopanib targets CSF1R",
"source_label": "pazopanib",
"target_label": "CSF1R",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "Binding constant for CSF1R kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "780",
"properties": {
"id": "pazopanib targets DDR1",
"source_label": "pazopanib",
"target_label": "DDR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.24",
"act_comment": "Binding constant for DDR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "4921",
"properties": {
"id": "pazopanib targets DDR2",
"source_label": "pazopanib",
"target_label": "DDR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.01",
"act_comment": "Binding constant for DDR2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "2051",
"properties": {
"id": "pazopanib targets EPHB6",
"source_label": "pazopanib",
"target_label": "EPHB6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.09",
"act_comment": "Binding constant for EPHB6 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "2260",
"properties": {
"id": "pazopanib targets FGFR1",
"source_label": "pazopanib",
"target_label": "FGFR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for FGFR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "2263",
"properties": {
"id": "pazopanib targets FGFR2",
"source_label": "pazopanib",
"target_label": "FGFR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Binding constant for FGFR2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "2261",
"properties": {
"id": "pazopanib targets FGFR3",
"source_label": "pazopanib",
"target_label": "FGFR3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Binding constant for FGFR3(G697C) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "2321",
"properties": {
"id": "pazopanib targets FLT1",
"source_label": "pazopanib",
"target_label": "FLT1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Binding constant for FLT1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "pazopanib targets FLT3",
"source_label": "pazopanib",
"target_label": "FLT3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "Binding constant for FLT3(K663Q) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "2324",
"properties": {
"id": "pazopanib targets FLT4",
"source_label": "pazopanib",
"target_label": "FLT4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.57",
"act_comment": "Binding constant for FLT4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "2444",
"properties": {
"id": "pazopanib targets FRK",
"source_label": "pazopanib",
"target_label": "FRK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Binding constant for FRK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "2580",
"properties": {
"id": "pazopanib targets GAK",
"source_label": "pazopanib",
"target_label": "GAK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Binding constant for GAK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "11213",
"properties": {
"id": "pazopanib targets IRAK3",
"source_label": "pazopanib",
"target_label": "IRAK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Binding constant for IRAK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "pazopanib targets KDR",
"source_label": "pazopanib",
"target_label": "KDR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Binding constant for VEGFR2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "pazopanib targets KIT",
"source_label": "pazopanib",
"target_label": "KIT",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.74",
"act_comment": "Binding constant for KIT(L576P) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "3984",
"properties": {
"id": "pazopanib targets LIMK1",
"source_label": "pazopanib",
"target_label": "LIMK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Binding constant for full-length LIMK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "3985",
"properties": {
"id": "pazopanib targets LIMK2",
"source_label": "pazopanib",
"target_label": "LIMK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "Binding constant for full-length LIMK2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "4067",
"properties": {
"id": "pazopanib targets LYN",
"source_label": "pazopanib",
"target_label": "LYN",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Binding constant for LYN kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "6416",
"properties": {
"id": "pazopanib targets MAP2K4",
"source_label": "pazopanib",
"target_label": "MAP2K4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.23",
"act_comment": "Binding constant for MEK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "5607",
"properties": {
"id": "pazopanib targets MAP2K5",
"source_label": "pazopanib",
"target_label": "MAP2K5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.32",
"act_comment": "Binding constant for MEK5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "4296",
"properties": {
"id": "pazopanib targets MAP3K11",
"source_label": "pazopanib",
"target_label": "MAP3K11",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "Binding constant for MLK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "80122",
"properties": {
"id": "pazopanib targets MAP3K19",
"source_label": "pazopanib",
"target_label": "MAP3K19",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "Binding constant for YSK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "10746",
"properties": {
"id": "pazopanib targets MAP3K2",
"source_label": "pazopanib",
"target_label": "MAP3K2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Binding constant for MAP3K2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "4293",
"properties": {
"id": "pazopanib targets MAP3K9",
"source_label": "pazopanib",
"target_label": "MAP3K9",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Binding constant for MLK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "11184",
"properties": {
"id": "pazopanib targets MAP4K1",
"source_label": "pazopanib",
"target_label": "MAP4K1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Binding constant for MAP4K1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "4751",
"properties": {
"id": "pazopanib targets NEK2",
"source_label": "pazopanib",
"target_label": "NEK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Binding constant for NEK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "5156",
"properties": {
"id": "pazopanib targets PDGFRA",
"source_label": "pazopanib",
"target_label": "PDGFRA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Binding constant for PDGFRA kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "pazopanib targets PDGFRB",
"source_label": "pazopanib",
"target_label": "PDGFRB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "Binding constant for PDGFRB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "5298",
"properties": {
"id": "pazopanib targets PI4KB",
"source_label": "pazopanib",
"target_label": "PI4KB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "Binding constant for PIK4CB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "79837",
"properties": {
"id": "pazopanib targets PIP4K2C",
"source_label": "pazopanib",
"target_label": "PIP4K2C",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Binding constant for PIP5K2C kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "10733",
"properties": {
"id": "pazopanib targets PLK4",
"source_label": "pazopanib",
"target_label": "PLK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Binding constant for PLK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "5894",
"properties": {
"id": "pazopanib targets RAF1",
"source_label": "pazopanib",
"target_label": "RAF1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Binding constant for RAF1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "pazopanib targets RET",
"source_label": "pazopanib",
"target_label": "RET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Binding constant for RET(M918T) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "55781",
"properties": {
"id": "pazopanib targets RIOK2",
"source_label": "pazopanib",
"target_label": "RIOK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Binding constant for RIOK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "8737",
"properties": {
"id": "pazopanib targets RIPK1",
"source_label": "pazopanib",
"target_label": "RIPK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "Binding constant for RIPK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "pazopanib targets RIPK2",
"source_label": "pazopanib",
"target_label": "RIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Binding constant for RIPK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "6098",
"properties": {
"id": "pazopanib targets ROS1",
"source_label": "pazopanib",
"target_label": "ROS1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "Binding constant for ROS1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "9748",
"properties": {
"id": "pazopanib targets SLK",
"source_label": "pazopanib",
"target_label": "SLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding constant for SLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "6793",
"properties": {
"id": "pazopanib targets STK10",
"source_label": "pazopanib",
"target_label": "STK10",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.08",
"act_comment": "Binding constant for LOK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "8576",
"properties": {
"id": "pazopanib targets STK16",
"source_label": "pazopanib",
"target_label": "STK16",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Binding constant for STK16 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "27148",
"properties": {
"id": "pazopanib targets STK36",
"source_label": "pazopanib",
"target_label": "STK36",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Binding constant for STK36 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "57551",
"properties": {
"id": "pazopanib targets TAOK1",
"source_label": "pazopanib",
"target_label": "TAOK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding constant for TAOK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "51347",
"properties": {
"id": "pazopanib targets TAOK3",
"source_label": "pazopanib",
"target_label": "TAOK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.35",
"act_comment": "Binding constant for TAOK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "7075",
"properties": {
"id": "pazopanib targets TIE1",
"source_label": "pazopanib",
"target_label": "TIE1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Binding constant for TIE1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "23043",
"properties": {
"id": "pazopanib targets TNIK",
"source_label": "pazopanib",
"target_label": "TNIK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "Binding constant for TNIK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "8711",
"properties": {
"id": "pazopanib targets TNK1",
"source_label": "pazopanib",
"target_label": "TNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Binding constant for full-length TNK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10113978",
"relation": "IDG (Drug Target)",
"target": "7272",
"properties": {
"id": "pazopanib targets TTK",
"source_label": "pazopanib",
"target_label": "TTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "Binding constant for TTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5352062",
"relation": "IDG (Drug Target)",
"target": "23476",
"properties": {
"id": "romidepsin targets BRD4",
"source_label": "romidepsin",
"target_label": "BRD4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.44",
"act_comment": "Inhibition of BRD4 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5352062",
"relation": "IDG (Drug Target)",
"target": "3065",
"properties": {
"id": "romidepsin targets HDAC1",
"source_label": "romidepsin",
"target_label": "HDAC1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5352062",
"relation": "IDG (Drug Target)",
"target": "3066",
"properties": {
"id": "romidepsin targets HDAC2",
"source_label": "romidepsin",
"target_label": "HDAC2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.328",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5352062",
"relation": "IDG (Drug Target)",
"target": "8841",
"properties": {
"id": "romidepsin targets HDAC3",
"source_label": "romidepsin",
"target_label": "HDAC3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.604",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5352062",
"relation": "IDG (Drug Target)",
"target": "9759",
"properties": {
"id": "romidepsin targets HDAC4",
"source_label": "romidepsin",
"target_label": "HDAC4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.292",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5352062",
"relation": "IDG (Drug Target)",
"target": "10014",
"properties": {
"id": "romidepsin targets HDAC5",
"source_label": "romidepsin",
"target_label": "HDAC5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5352062",
"relation": "IDG (Drug Target)",
"target": "10013",
"properties": {
"id": "romidepsin targets HDAC6",
"source_label": "romidepsin",
"target_label": "HDAC6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.523",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5352062",
"relation": "IDG (Drug Target)",
"target": "55869",
"properties": {
"id": "romidepsin targets HDAC8",
"source_label": "romidepsin",
"target_label": "HDAC8",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.82",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:68841",
"relation": "IDG (Drug Target)",
"target": "2914",
"properties": {
"id": "dexfosfoserine targets GRM4",
"source_label": "dexfosfoserine",
"target_label": "GRM4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:68841",
"relation": "IDG (Drug Target)",
"target": "2916",
"properties": {
"id": "dexfosfoserine targets GRM6",
"source_label": "dexfosfoserine",
"target_label": "GRM6",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:68841",
"relation": "IDG (Drug Target)",
"target": "2918",
"properties": {
"id": "dexfosfoserine targets GRM8",
"source_label": "dexfosfoserine",
"target_label": "GRM8",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5311",
"relation": "IDG (Drug Target)",
"target": "23476",
"properties": {
"id": "vorinostat targets BRD4",
"source_label": "vorinostat",
"target_label": "BRD4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Inhibition of BRD4 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311",
"relation": "IDG (Drug Target)",
"target": "3065",
"properties": {
"id": "vorinostat targets HDAC1",
"source_label": "vorinostat",
"target_label": "HDAC1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.89",
"act_comment": "Inhibition of human HDAC1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311",
"relation": "IDG (Drug Target)",
"target": "83933",
"properties": {
"id": "vorinostat targets HDAC10",
"source_label": "vorinostat",
"target_label": "HDAC10",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Inhibition of HDAC10",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311",
"relation": "IDG (Drug Target)",
"target": "79885",
"properties": {
"id": "vorinostat targets HDAC11",
"source_label": "vorinostat",
"target_label": "HDAC11",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Inhibition of recombinant human HDAC11 enzyme using Ac-LeuGlyLys(Ac)-AMC as substrate after 15 to 30 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311",
"relation": "IDG (Drug Target)",
"target": "3066",
"properties": {
"id": "vorinostat targets HDAC2",
"source_label": "vorinostat",
"target_label": "HDAC2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "Inhibition of human HDAC2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311",
"relation": "IDG (Drug Target)",
"target": "8841",
"properties": {
"id": "vorinostat targets HDAC3",
"source_label": "vorinostat",
"target_label": "HDAC3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "Inhibition of human HDAC3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311",
"relation": "IDG (Drug Target)",
"target": "9759",
"properties": {
"id": "vorinostat targets HDAC4",
"source_label": "vorinostat",
"target_label": "HDAC4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "Inhibition of HDAC4",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311",
"relation": "IDG (Drug Target)",
"target": "10014",
"properties": {
"id": "vorinostat targets HDAC5",
"source_label": "vorinostat",
"target_label": "HDAC5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.48",
"act_comment": "Inhibition of HDAC5",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311",
"relation": "IDG (Drug Target)",
"target": "10013",
"properties": {
"id": "vorinostat targets HDAC6",
"source_label": "vorinostat",
"target_label": "HDAC6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC6 by fluorescence polarization assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311",
"relation": "IDG (Drug Target)",
"target": "51564",
"properties": {
"id": "vorinostat targets HDAC7",
"source_label": "vorinostat",
"target_label": "HDAC7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Competitive inhibition of HDAC7 using KI-104 as substrate by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311",
"relation": "IDG (Drug Target)",
"target": "55869",
"properties": {
"id": "vorinostat targets HDAC8",
"source_label": "vorinostat",
"target_label": "HDAC8",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.76",
"act_comment": "Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311",
"relation": "IDG (Drug Target)",
"target": "9734",
"properties": {
"id": "vorinostat targets HDAC9",
"source_label": "vorinostat",
"target_label": "HDAC9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.31",
"act_comment": "Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "paliperidone targets ADRA1A",
"source_label": "paliperidone",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.553",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "paliperidone targets ADRA1B",
"source_label": "paliperidone",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.155",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "paliperidone targets ADRA2A",
"source_label": "paliperidone",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.925",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "paliperidone targets ADRA2B",
"source_label": "paliperidone",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.635",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "paliperidone targets ADRA2C",
"source_label": "paliperidone",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.195",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "paliperidone targets DRD1",
"source_label": "paliperidone",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.387",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "paliperidone targets DRD2",
"source_label": "paliperidone",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.47",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "paliperidone targets DRD3",
"source_label": "paliperidone",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.046",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "paliperidone targets DRD4",
"source_label": "paliperidone",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.265",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "1816",
"properties": {
"id": "paliperidone targets DRD5",
"source_label": "paliperidone",
"target_label": "DRD5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.538",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "paliperidone targets HRH1",
"source_label": "paliperidone",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.251",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "paliperidone targets HRH2",
"source_label": "paliperidone",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.916",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "paliperidone targets HTR1A",
"source_label": "paliperidone",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.218",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "paliperidone targets HTR1B",
"source_label": "paliperidone",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.638",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "paliperidone targets HTR1D",
"source_label": "paliperidone",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.721",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "paliperidone targets HTR2A",
"source_label": "paliperidone",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.959",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "paliperidone targets HTR2B",
"source_label": "paliperidone",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.209",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "paliperidone targets HTR2C",
"source_label": "paliperidone",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.319",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "paliperidone targets HTR5A",
"source_label": "paliperidone",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.556",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:115237",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "paliperidone targets HTR7",
"source_label": "paliperidone",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.569",
"act_comment": "nan",
"act_source": "PDSP"
}
},
{
"source": "CID:3468",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "gentian violet targets ADRA1D",
"source_label": "gentian violet",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.012",
"act_comment": "DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3468",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "gentian violet targets ADRA2A",
"source_label": "gentian violet",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.697",
"act_comment": "DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3468",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "gentian violet targets ADRA2B",
"source_label": "gentian violet",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.241",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3468",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "gentian violet targets ADRA2C",
"source_label": "gentian violet",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.562",
"act_comment": "DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3468",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "gentian violet targets CHRM1",
"source_label": "gentian violet",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.578",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3468",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "gentian violet targets CHRM2",
"source_label": "gentian violet",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.294",
"act_comment": "DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3468",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "gentian violet targets CHRM3",
"source_label": "gentian violet",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.037",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3468",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "gentian violet targets CHRM4",
"source_label": "gentian violet",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.854",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3468",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "gentian violet targets CHRM5",
"source_label": "gentian violet",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.416",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3468",
"relation": "IDG (Drug Target)",
"target": "1565",
"properties": {
"id": "gentian violet targets CYP2D6",
"source_label": "gentian violet",
"target_label": "CYP2D6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.084",
"act_comment": "DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3468",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "gentian violet targets DRD3",
"source_label": "gentian violet",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3468",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "gentian violet targets EGFR",
"source_label": "gentian violet",
"target_label": "EGFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.325",
"act_comment": "DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr))",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3468",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "gentian violet targets HTR2A",
"source_label": "gentian violet",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.124",
"act_comment": "DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3468",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "gentian violet targets OPRK1",
"source_label": "gentian violet",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3468",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "gentian violet targets OPRM1",
"source_label": "gentian violet",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.06",
"act_comment": "DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:3468",
"relation": "IDG (Drug Target)",
"target": "6865",
"properties": {
"id": "gentian violet targets TACR2",
"source_label": "gentian violet",
"target_label": "TACR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.252",
"act_comment": "DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:135413547",
"relation": "IDG (Drug Target)",
"target": "8654",
"properties": {
"id": "udenafil targets PDE5A",
"source_label": "udenafil",
"target_label": "PDE5A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.084",
"act_comment": "PDE5 activity in human platelets",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5995",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "testosterone propionate targets AR",
"source_label": "testosterone propionate",
"target_label": "AR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.6",
"act_comment": "Displacement of [3H]DHT from human androgen receptor in MDA453 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5995",
"relation": "IDG (Drug Target)",
"target": "1586",
"properties": {
"id": "testosterone propionate targets CYP17A1",
"source_label": "testosterone propionate",
"target_label": "CYP17A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.25",
"act_comment": "In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escherichia coli or P450c17-LNCaP cells as the enzyme source.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:104850",
"relation": "IDG (Drug Target)",
"target": "1268",
"properties": {
"id": "rimonabant targets CNR1",
"source_label": "rimonabant",
"target_label": "CNR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.72",
"act_comment": "Antagonist activity against human CB1 receptor expressed in CHO-K1 cells by [35S]GTPgamma binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:104850",
"relation": "IDG (Drug Target)",
"target": "1269",
"properties": {
"id": "rimonabant targets CNR2",
"source_label": "rimonabant",
"target_label": "CNR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.96",
"act_comment": "Displacement of [3H]-CP-55940 from human CB2 receptor expressed in HEK293T cell membranes by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5312125",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "silodosin targets ADRA1A",
"source_label": "silodosin",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.44",
"act_comment": "Binding constant measured against Alpha-1A adrenergic receptor in human prostate; +++:highly active",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5312125",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "silodosin targets ADRA1B",
"source_label": "silodosin",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:5312125",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "silodosin targets ADRA1D",
"source_label": "silodosin",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:16134956",
"relation": "IDG (Drug Target)",
"target": "2740",
"properties": {
"id": "liraglutide targets GLP1R",
"source_label": "liraglutide",
"target_label": "GLP1R",
"act_type": "EC50",
"act_relation": "=",
"act_value": "10.2",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:130904",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "ulipristal targets PGR",
"source_label": "ulipristal",
"target_label": "PGR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:107970",
"relation": "IDG (Drug Target)",
"target": "1901",
"properties": {
"id": "fingolimod targets S1PR1",
"source_label": "fingolimod",
"target_label": "S1PR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.52",
"act_comment": "Agonist activity at S1P1 receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:107970",
"relation": "IDG (Drug Target)",
"target": "1903",
"properties": {
"id": "fingolimod targets S1PR3",
"source_label": "fingolimod",
"target_label": "S1PR3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "Agonist activity at S1P3 receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:107970",
"relation": "IDG (Drug Target)",
"target": "8698",
"properties": {
"id": "fingolimod targets S1PR4",
"source_label": "fingolimod",
"target_label": "S1PR4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.52",
"act_comment": "Agonist activity at S1P4 receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:107970",
"relation": "IDG (Drug Target)",
"target": "53637",
"properties": {
"id": "fingolimod targets S1PR5",
"source_label": "fingolimod",
"target_label": "S1PR5",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.52",
"act_comment": "Agonist activity at S1P5 receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:213046",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "lurasidone targets ADRA2A",
"source_label": "lurasidone",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.39",
"act_comment": "antagonist",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:213046",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "lurasidone targets ADRA2C",
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"act_value": "7.967",
"act_comment": "antagonist with moderate affinity",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:213046",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "lurasidone targets DRD2",
"source_label": "lurasidone",
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"act_comment": "Mechanism of Action",
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}
},
{
"source": "CID:213046",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "lurasidone targets HTR1A",
"source_label": "lurasidone",
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"act_value": "8.195",
"act_comment": "partial agonist",
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}
},
{
"source": "CID:213046",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "lurasidone targets HTR2A",
"source_label": "lurasidone",
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"act_value": "9.328",
"act_comment": "Mechanism of Action",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:213046",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "lurasidone targets HTR7",
"source_label": "lurasidone",
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"act_type": "Ki",
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"act_value": "9.305",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:10324367",
"relation": "IDG (Drug Target)",
"target": "1215",
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"id": "boceprevir targets CMA1",
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"act_value": "7.49",
"act_comment": "Inhibition of human Chymase",
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}
},
{
"source": "CID:10324367",
"relation": "IDG (Drug Target)",
"target": "5476",
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"id": "boceprevir targets CTSA",
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"act_value": "6.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:10324367",
"relation": "IDG (Drug Target)",
"target": "1513",
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"id": "boceprevir targets CTSK",
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"act_relation": "=",
"act_value": "7.4",
"act_comment": "Inhibition of human Cathepsin K",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10324367",
"relation": "IDG (Drug Target)",
"target": "1514",
"properties": {
"id": "boceprevir targets CTSL",
"source_label": "boceprevir",
"target_label": "CTSL",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Inhibition of human Cathepsin L",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10324367",
"relation": "IDG (Drug Target)",
"target": "1520",
"properties": {
"id": "boceprevir targets CTSS",
"source_label": "boceprevir",
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"act_value": "6.92",
"act_comment": "Inhibition of human Cathepsin S",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10324367",
"relation": "IDG (Drug Target)",
"target": "1515",
"properties": {
"id": "boceprevir targets CTSV",
"source_label": "boceprevir",
"target_label": "CTSV",
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"act_relation": "=",
"act_value": "7.12",
"act_comment": "Inhibition of human Cathepsin V",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3010818",
"relation": "IDG (Drug Target)",
"target": "1990",
"properties": {
"id": "telaprevir targets CELA1",
"source_label": "telaprevir",
"target_label": "CELA1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "Inhibition of human Pancreatic elastase 1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3010818",
"relation": "IDG (Drug Target)",
"target": "1215",
"properties": {
"id": "telaprevir targets CMA1",
"source_label": "telaprevir",
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"act_relation": "=",
"act_value": "7.59",
"act_comment": "Inhibition of human Chymase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3010818",
"relation": "IDG (Drug Target)",
"target": "5476",
"properties": {
"id": "telaprevir targets CTSA",
"source_label": "telaprevir",
"target_label": "CTSA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:3010818",
"relation": "IDG (Drug Target)",
"target": "1508",
"properties": {
"id": "telaprevir targets CTSB",
"source_label": "telaprevir",
"target_label": "CTSB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Inhibition of cathepsin B",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3010818",
"relation": "IDG (Drug Target)",
"target": "1513",
"properties": {
"id": "telaprevir targets CTSK",
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"target_label": "CTSK",
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"act_relation": "=",
"act_value": "6.2",
"act_comment": "Inhibition of human Cathepsin K",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3010818",
"relation": "IDG (Drug Target)",
"target": "1520",
"properties": {
"id": "telaprevir targets CTSS",
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"act_relation": "=",
"act_value": "6.52",
"act_comment": "Inhibition of human Cathepsin S",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3010818",
"relation": "IDG (Drug Target)",
"target": "1991",
"properties": {
"id": "telaprevir targets ELANE",
"source_label": "telaprevir",
"target_label": "ELANE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Inhibition of human leukocyte elastase after 60 mins fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6451164",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "rilpivirine targets KCNH2",
"source_label": "rilpivirine",
"target_label": "KCNH2",
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"act_relation": "=",
"act_value": "6.3",
"act_comment": "Inhibition of human ERG",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10096344",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "linagliptin targets CHRM1",
"source_label": "linagliptin",
"target_label": "CHRM1",
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"act_relation": "=",
"act_value": "6.53",
"act_comment": "Displacement of [N-methyl-3H]scopolamine from human recombinant muscarinic M1 receptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10096344",
"relation": "IDG (Drug Target)",
"target": "1803",
"properties": {
"id": "linagliptin targets DPP4",
"source_label": "linagliptin",
"target_label": "DPP4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.0",
"act_comment": "Inhibition of human C-terminal step-tagged DPP4 expressed using baculovirus system",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10096344",
"relation": "IDG (Drug Target)",
"target": "2191",
"properties": {
"id": "linagliptin targets FAP",
"source_label": "linagliptin",
"target_label": "FAP",
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"act_relation": "=",
"act_value": "7.05",
"act_comment": "Inhibition of FAPalpha",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9821849",
"relation": "IDG (Drug Target)",
"target": "1586",
"properties": {
"id": "abiraterone acetate targets CYP17A1",
"source_label": "abiraterone acetate",
"target_label": "CYP17A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.54",
"act_comment": "Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "vandetanib targets ABL1",
"source_label": "vandetanib",
"target_label": "ABL1",
"act_type": "Kd",
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"act_value": "8.05",
"act_comment": "Binding constant for ABL1(Y253F)-phosphorylated kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "27",
"properties": {
"id": "vandetanib targets ABL2",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "7.16",
"act_comment": "Binding constant for ABL2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "90",
"properties": {
"id": "vandetanib targets ACVR1",
"source_label": "vandetanib",
"target_label": "ACVR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "Binding constant for ACVR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "94",
"properties": {
"id": "vandetanib targets ACVRL1",
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"target_label": "ACVRL1",
"act_type": "Kd",
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"act_value": "6.33",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "558",
"properties": {
"id": "vandetanib targets AXL",
"source_label": "vandetanib",
"target_label": "AXL",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Binding constant for AXL kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "613",
"properties": {
"id": "vandetanib targets BCR",
"source_label": "vandetanib",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.06",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "640",
"properties": {
"id": "vandetanib targets BLK",
"source_label": "vandetanib",
"target_label": "BLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.18",
"act_comment": "Binding constant for BLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "658",
"properties": {
"id": "vandetanib targets BMPR1B",
"source_label": "vandetanib",
"target_label": "BMPR1B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding constant for BMPR1B kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "780",
"properties": {
"id": "vandetanib targets DDR1",
"source_label": "vandetanib",
"target_label": "DDR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Binding constant for DDR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "4921",
"properties": {
"id": "vandetanib targets DDR2",
"source_label": "vandetanib",
"target_label": "DDR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.49",
"act_comment": "Binding constant for DDR2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "vandetanib targets EGFR",
"source_label": "vandetanib",
"target_label": "EGFR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.32",
"act_comment": "Binding constant for EGFR(E746-A750del) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "2041",
"properties": {
"id": "vandetanib targets EPHA1",
"source_label": "vandetanib",
"target_label": "EPHA1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Binding constant for EPHA1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "2044",
"properties": {
"id": "vandetanib targets EPHA5",
"source_label": "vandetanib",
"target_label": "EPHA5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding constant for EPHA5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "285220",
"properties": {
"id": "vandetanib targets EPHA6",
"source_label": "vandetanib",
"target_label": "EPHA6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Binding constant for EPHA6 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "2046",
"properties": {
"id": "vandetanib targets EPHA8",
"source_label": "vandetanib",
"target_label": "EPHA8",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.04",
"act_comment": "Binding constant for EPHA8 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "2047",
"properties": {
"id": "vandetanib targets EPHB1",
"source_label": "vandetanib",
"target_label": "EPHB1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Binding constant for EPHB1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "2048",
"properties": {
"id": "vandetanib targets EPHB2",
"source_label": "vandetanib",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Binding constant for EPHB2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "2050",
"properties": {
"id": "vandetanib targets EPHB4",
"source_label": "vandetanib",
"target_label": "EPHB4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Binding constant for EPHB4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "2051",
"properties": {
"id": "vandetanib targets EPHB6",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "7.12",
"act_comment": "Binding constant for EPHB6 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "2065",
"properties": {
"id": "vandetanib targets ERBB3",
"source_label": "vandetanib",
"target_label": "ERBB3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "Binding constant for ERBB3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "2066",
"properties": {
"id": "vandetanib targets ERBB4",
"source_label": "vandetanib",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.32",
"act_comment": "Binding constant for ERBB4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "2260",
"properties": {
"id": "vandetanib targets FGFR1",
"source_label": "vandetanib",
"target_label": "FGFR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "Binding constant for FGFR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "2261",
"properties": {
"id": "vandetanib targets FGFR3",
"source_label": "vandetanib",
"target_label": "FGFR3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Average Binding Constant for FGFR3; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "2268",
"properties": {
"id": "vandetanib targets FGR",
"source_label": "vandetanib",
"target_label": "FGR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Binding constant for FGR kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "2321",
"properties": {
"id": "vandetanib targets FLT1",
"source_label": "vandetanib",
"target_label": "FLT1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "Binding constant for FLT1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "vandetanib targets FLT3",
"source_label": "vandetanib",
"target_label": "FLT3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Binding constant for FLT3(K663Q) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "2324",
"properties": {
"id": "vandetanib targets FLT4",
"source_label": "vandetanib",
"target_label": "FLT4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Average Binding Constant for FLT4; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "2444",
"properties": {
"id": "vandetanib targets FRK",
"source_label": "vandetanib",
"target_label": "FRK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Binding constant for FRK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "2534",
"properties": {
"id": "vandetanib targets FYN",
"source_label": "vandetanib",
"target_label": "FYN",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Binding constant for FYN kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "2580",
"properties": {
"id": "vandetanib targets GAK",
"source_label": "vandetanib",
"target_label": "GAK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.07",
"act_comment": "Binding constant for GAK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "3055",
"properties": {
"id": "vandetanib targets HCK",
"source_label": "vandetanib",
"target_label": "HCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Binding constant for HCK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "51135",
"properties": {
"id": "vandetanib targets IRAK4",
"source_label": "vandetanib",
"target_label": "IRAK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.12",
"act_comment": "Binding constant for IRAK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "vandetanib targets KDR",
"source_label": "vandetanib",
"target_label": "KDR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Average Binding Constant for VEGFR2; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "vandetanib targets KIT",
"source_label": "vandetanib",
"target_label": "KIT",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.47",
"act_comment": "Binding constant for KIT(A829P) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "vandetanib targets LCK",
"source_label": "vandetanib",
"target_label": "LCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "Binding constant for LCK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "4058",
"properties": {
"id": "vandetanib targets LTK",
"source_label": "vandetanib",
"target_label": "LTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "Binding constant for LTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "4067",
"properties": {
"id": "vandetanib targets LYN",
"source_label": "vandetanib",
"target_label": "LYN",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Binding constant for LYN kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "5607",
"properties": {
"id": "vandetanib targets MAP2K5",
"source_label": "vandetanib",
"target_label": "MAP2K5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.31",
"act_comment": "Binding constant for MEK5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "80122",
"properties": {
"id": "vandetanib targets MAP3K19",
"source_label": "vandetanib",
"target_label": "MAP3K19",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Binding constant for YSK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "11183",
"properties": {
"id": "vandetanib targets MAP4K5",
"source_label": "vandetanib",
"target_label": "MAP4K5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Binding constant for MAP4K5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "8569",
"properties": {
"id": "vandetanib targets MKNK1",
"source_label": "vandetanib",
"target_label": "MKNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Binding constant for full-length MKNK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "5156",
"properties": {
"id": "vandetanib targets PDGFRA",
"source_label": "vandetanib",
"target_label": "PDGFRA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Binding constant for PDGFRA kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "vandetanib targets PDGFRB",
"source_label": "vandetanib",
"target_label": "PDGFRB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.06",
"act_comment": "Binding constant for PDGFRB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "10733",
"properties": {
"id": "vandetanib targets PLK4",
"source_label": "vandetanib",
"target_label": "PLK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Binding constant for PLK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "5753",
"properties": {
"id": "vandetanib targets PTK6",
"source_label": "vandetanib",
"target_label": "PTK6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.48",
"act_comment": "Average Binding Constant for PTK6; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "vandetanib targets RET",
"source_label": "vandetanib",
"target_label": "RET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Binding constant for RET(M918T) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "vandetanib targets RIPK2",
"source_label": "vandetanib",
"target_label": "RIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.34",
"act_comment": "Binding constant for RIPK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "54101",
"properties": {
"id": "vandetanib targets RIPK4",
"source_label": "vandetanib",
"target_label": "RIPK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Binding constant for RIPK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "6195",
"properties": {
"id": "vandetanib targets RPS6KA1",
"source_label": "vandetanib",
"target_label": "RPS6KA1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Binding constant for RPS6KA1(Kin.Dom.2 - C-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "27330",
"properties": {
"id": "vandetanib targets RPS6KA6",
"source_label": "vandetanib",
"target_label": "RPS6KA6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding constant for RPS6KA6(Kin.Dom.2 - N-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "23235",
"properties": {
"id": "vandetanib targets SIK2",
"source_label": "vandetanib",
"target_label": "SIK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "Binding constant for full-length SNF1LK2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "9748",
"properties": {
"id": "vandetanib targets SLK",
"source_label": "vandetanib",
"target_label": "SLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.02",
"act_comment": "Average Binding Constant for SLK; NA=Not Active at 10 uM",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "6714",
"properties": {
"id": "vandetanib targets SRC",
"source_label": "vandetanib",
"target_label": "SRC",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "Binding constant for SRC kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "6793",
"properties": {
"id": "vandetanib targets STK10",
"source_label": "vandetanib",
"target_label": "STK10",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.09",
"act_comment": "Binding constant for LOK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "140901",
"properties": {
"id": "vandetanib targets STK35",
"source_label": "vandetanib",
"target_label": "STK35",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.25",
"act_comment": "Binding constant for STK35 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "7010",
"properties": {
"id": "vandetanib targets TEK",
"source_label": "vandetanib",
"target_label": "TEK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for TIE2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "7301",
"properties": {
"id": "vandetanib targets TYRO3",
"source_label": "vandetanib",
"target_label": "TYRO3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.03",
"act_comment": "Binding constant for TYRO3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3081361",
"relation": "IDG (Drug Target)",
"target": "7525",
"properties": {
"id": "vandetanib targets YES1",
"source_label": "vandetanib",
"target_label": "YES1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Binding constant for YES kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:121892",
"relation": "IDG (Drug Target)",
"target": "3786",
"properties": {
"id": "retigabine targets KCNQ3",
"source_label": "retigabine",
"target_label": "KCNQ3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9875401",
"relation": "IDG (Drug Target)",
"target": "2159",
"properties": {
"id": "rivaroxaban targets F10",
"source_label": "rivaroxaban",
"target_label": "F10",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "Inhibition of Factor 10a",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918554",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "indacaterol targets ADRB1",
"source_label": "indacaterol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.04",
"act_comment": "Displacement of [3H]CGP12177 from human beta-1 adrenoceptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918554",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "indacaterol targets ADRB2",
"source_label": "indacaterol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "Binding affinity to human beta2-adrenoceptor by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9871419",
"relation": "IDG (Drug Target)",
"target": "64805",
"properties": {
"id": "ticagrelor targets P2RY12",
"source_label": "ticagrelor",
"target_label": "P2RY12",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Displacement of [33P]2-MeS-ADP from human recombinant P2Y12 receptor expressed in CHO cell membranes by scintillation counting method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9871419",
"relation": "IDG (Drug Target)",
"target": "2030",
"properties": {
"id": "ticagrelor targets SLC29A1",
"source_label": "ticagrelor",
"target_label": "SLC29A1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:42611257",
"relation": "IDG (Drug Target)",
"target": "369",
"properties": {
"id": "vemurafenib targets ARAF",
"source_label": "vemurafenib",
"target_label": "ARAF",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:42611257",
"relation": "IDG (Drug Target)",
"target": "673",
"properties": {
"id": "vemurafenib targets BRAF",
"source_label": "vemurafenib",
"target_label": "BRAF",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.68",
"act_comment": "Inhibition of wild type BRAF (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:42611257",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "vemurafenib targets KDR",
"source_label": "vemurafenib",
"target_label": "KDR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:42611257",
"relation": "IDG (Drug Target)",
"target": "5607",
"properties": {
"id": "vemurafenib targets MAP2K5",
"source_label": "vemurafenib",
"target_label": "MAP2K5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:42611257",
"relation": "IDG (Drug Target)",
"target": "5894",
"properties": {
"id": "vemurafenib targets RAF1",
"source_label": "vemurafenib",
"target_label": "RAF1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.32",
"act_comment": "Inhibition of C-Raf in presence of 100 uM ATP",
"act_source": "CHEMBL"
}
},
{
"source": "CID:42611257",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "vemurafenib targets RIPK2",
"source_label": "vemurafenib",
"target_label": "RIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:42611257",
"relation": "IDG (Drug Target)",
"target": "51776",
"properties": {
"id": "vemurafenib targets MAP3K20",
"source_label": "vemurafenib",
"target_label": "MAP3K20",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.64",
"act_comment": "Inhibition of human ZAK (5 to 309 residues) expressed in baculovirus infected Sf9 insect cells using ZAKtide as substrate after 1 hr by mass spectrometry",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918173",
"relation": "IDG (Drug Target)",
"target": "623",
"properties": {
"id": "icatibant targets BDKRB1",
"source_label": "icatibant",
"target_label": "BDKRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6918173",
"relation": "IDG (Drug Target)",
"target": "624",
"properties": {
"id": "icatibant targets BDKRB2",
"source_label": "icatibant",
"target_label": "BDKRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.22",
"act_comment": "Binding affinity towards human cloned Bradykinin receptor B2 expressed in CHO cells by [3H]bradykinin displacement.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "crizotinib targets ABL1",
"source_label": "crizotinib",
"target_label": "ABL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Binding constant for ABL1(T315I)-phosphorylated kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "27",
"properties": {
"id": "crizotinib targets ABL2",
"source_label": "crizotinib",
"target_label": "ABL2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.34",
"act_comment": "Binding constant for ABL2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "90",
"properties": {
"id": "crizotinib targets ACVR1",
"source_label": "crizotinib",
"target_label": "ACVR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Binding constant for ACVR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "91",
"properties": {
"id": "crizotinib targets ACVR1B",
"source_label": "crizotinib",
"target_label": "ACVR1B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "Binding constant for ACVR1B kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "238",
"properties": {
"id": "crizotinib targets ALK",
"source_label": "crizotinib",
"target_label": "ALK",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.13",
"act_comment": "Inhibition of wild type human recombinant ALK kinase domain (amino acids 1093 to 1141) expressed in baculovirus system using 5'FAM-KKSRGDYMTMQIG-CONH2 as substrate incubated for 15 mins prior to ATP addition measured after 1 hr by microfluidic mobility shift assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "255239",
"properties": {
"id": "crizotinib targets ANKK1",
"source_label": "crizotinib",
"target_label": "ANKK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Binding constant for ANKK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "6790",
"properties": {
"id": "crizotinib targets AURKA",
"source_label": "crizotinib",
"target_label": "AURKA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "Binding constant for AURKA kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "9212",
"properties": {
"id": "crizotinib targets AURKB",
"source_label": "crizotinib",
"target_label": "AURKB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.12",
"act_comment": "Binding constant for AURKB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "558",
"properties": {
"id": "crizotinib targets AXL",
"source_label": "crizotinib",
"target_label": "AXL",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.11",
"act_comment": "Binding constant for AXL kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "640",
"properties": {
"id": "crizotinib targets BLK",
"source_label": "crizotinib",
"target_label": "BLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Binding constant for BLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "55589",
"properties": {
"id": "crizotinib targets BMP2K",
"source_label": "crizotinib",
"target_label": "BMP2K",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "Binding constant for BIKE kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "658",
"properties": {
"id": "crizotinib targets BMPR1B",
"source_label": "crizotinib",
"target_label": "BMPR1B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Binding constant for BMPR1B kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "8573",
"properties": {
"id": "crizotinib targets CASK",
"source_label": "crizotinib",
"target_label": "CASK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Binding constant for CASK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "728642",
"properties": {
"id": "crizotinib targets CDK11A",
"source_label": "crizotinib",
"target_label": "CDK11A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Binding constant for CDC2L2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "984",
"properties": {
"id": "crizotinib targets CDK11B",
"source_label": "crizotinib",
"target_label": "CDK11B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Binding constant for CDC2L1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "1022",
"properties": {
"id": "crizotinib targets CDK7",
"source_label": "crizotinib",
"target_label": "CDK7",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Binding constant for CDK7 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "1436",
"properties": {
"id": "crizotinib targets CSF1R",
"source_label": "crizotinib",
"target_label": "CSF1R",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Binding constant for CSF1R kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "9201",
"properties": {
"id": "crizotinib targets DCLK1",
"source_label": "crizotinib",
"target_label": "DCLK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Binding constant for DCAMKL1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "166614",
"properties": {
"id": "crizotinib targets DCLK2",
"source_label": "crizotinib",
"target_label": "DCLK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.43",
"act_comment": "Binding constant for DCAMKL2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "780",
"properties": {
"id": "crizotinib targets DDR1",
"source_label": "crizotinib",
"target_label": "DDR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "Binding constant for DDR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "25778",
"properties": {
"id": "crizotinib targets DSTYK",
"source_label": "crizotinib",
"target_label": "DSTYK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Binding constant for RIPK5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "2041",
"properties": {
"id": "crizotinib targets EPHA1",
"source_label": "crizotinib",
"target_label": "EPHA1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Binding constant for EPHA1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "1969",
"properties": {
"id": "crizotinib targets EPHA2",
"source_label": "crizotinib",
"target_label": "EPHA2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Binding constant for EPHA2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "2042",
"properties": {
"id": "crizotinib targets EPHA3",
"source_label": "crizotinib",
"target_label": "EPHA3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Binding constant for EPHA3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "2043",
"properties": {
"id": "crizotinib targets EPHA4",
"source_label": "crizotinib",
"target_label": "EPHA4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Binding constant for EPHA4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "2044",
"properties": {
"id": "crizotinib targets EPHA5",
"source_label": "crizotinib",
"target_label": "EPHA5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for EPHA5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "285220",
"properties": {
"id": "crizotinib targets EPHA6",
"source_label": "crizotinib",
"target_label": "EPHA6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.19",
"act_comment": "Binding constant for EPHA6 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "2045",
"properties": {
"id": "crizotinib targets EPHA7",
"source_label": "crizotinib",
"target_label": "EPHA7",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Binding constant for EPHA7 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "2046",
"properties": {
"id": "crizotinib targets EPHA8",
"source_label": "crizotinib",
"target_label": "EPHA8",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Binding constant for EPHA8 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "2047",
"properties": {
"id": "crizotinib targets EPHB1",
"source_label": "crizotinib",
"target_label": "EPHB1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Binding constant for EPHB1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "2050",
"properties": {
"id": "crizotinib targets EPHB4",
"source_label": "crizotinib",
"target_label": "EPHB4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Binding constant for EPHB4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "2051",
"properties": {
"id": "crizotinib targets EPHB6",
"source_label": "crizotinib",
"target_label": "EPHB6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "Binding constant for EPHB6 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "2241",
"properties": {
"id": "crizotinib targets FER",
"source_label": "crizotinib",
"target_label": "FER",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Binding constant for FER kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "2242",
"properties": {
"id": "crizotinib targets FES",
"source_label": "crizotinib",
"target_label": "FES",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Binding constant for FES kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "2268",
"properties": {
"id": "crizotinib targets FGR",
"source_label": "crizotinib",
"target_label": "FGR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Binding constant for FGR kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "crizotinib targets FLT3",
"source_label": "crizotinib",
"target_label": "FLT3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Binding constant for FLT3(D835Y) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "3480",
"properties": {
"id": "crizotinib targets IGF1R",
"source_label": "crizotinib",
"target_label": "IGF1R",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Binding constant for IGF1R kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "9641",
"properties": {
"id": "crizotinib targets IKBKE",
"source_label": "crizotinib",
"target_label": "IKBKE",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Binding constant for IKK-epsilon kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "3643",
"properties": {
"id": "crizotinib targets INSR",
"source_label": "crizotinib",
"target_label": "INSR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "Binding constant for INSR kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "3645",
"properties": {
"id": "crizotinib targets INSRR",
"source_label": "crizotinib",
"target_label": "INSRR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Binding constant for INSRR kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "3654",
"properties": {
"id": "crizotinib targets IRAK1",
"source_label": "crizotinib",
"target_label": "IRAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.31",
"act_comment": "Binding constant for IRAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "11213",
"properties": {
"id": "crizotinib targets IRAK3",
"source_label": "crizotinib",
"target_label": "IRAK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.51",
"act_comment": "Binding constant for IRAK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "3716",
"properties": {
"id": "crizotinib targets JAK1",
"source_label": "crizotinib",
"target_label": "JAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Binding constant for JAK1(JH1domain-catalytic) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "3717",
"properties": {
"id": "crizotinib targets JAK2",
"source_label": "crizotinib",
"target_label": "JAK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Binding constant for JAK2(JH1domain-catalytic) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "3718",
"properties": {
"id": "crizotinib targets JAK3",
"source_label": "crizotinib",
"target_label": "JAK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Binding constant for JAK3(JH1domain-catalytic) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "crizotinib targets KIT",
"source_label": "crizotinib",
"target_label": "KIT",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Binding constant for KIT(V559D,T670I) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "crizotinib targets LCK",
"source_label": "crizotinib",
"target_label": "LCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "Binding constant for LCK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "3984",
"properties": {
"id": "crizotinib targets LIMK1",
"source_label": "crizotinib",
"target_label": "LIMK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.08",
"act_comment": "Binding constant for LIMK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "3985",
"properties": {
"id": "crizotinib targets LIMK2",
"source_label": "crizotinib",
"target_label": "LIMK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "Binding constant for LIMK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "4058",
"properties": {
"id": "crizotinib targets LTK",
"source_label": "crizotinib",
"target_label": "LTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Binding constant for LTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "4067",
"properties": {
"id": "crizotinib targets LYN",
"source_label": "crizotinib",
"target_label": "LYN",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "Binding constant for LYN kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "7786",
"properties": {
"id": "crizotinib targets MAP3K12",
"source_label": "crizotinib",
"target_label": "MAP3K12",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Binding constant for DLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "9175",
"properties": {
"id": "crizotinib targets MAP3K13",
"source_label": "crizotinib",
"target_label": "MAP3K13",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Binding constant for LZK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "80122",
"properties": {
"id": "crizotinib targets MAP3K19",
"source_label": "crizotinib",
"target_label": "MAP3K19",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Binding constant for YSK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "10746",
"properties": {
"id": "crizotinib targets MAP3K2",
"source_label": "crizotinib",
"target_label": "MAP3K2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.14",
"act_comment": "Binding constant for MAP3K2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "4215",
"properties": {
"id": "crizotinib targets MAP3K3",
"source_label": "crizotinib",
"target_label": "MAP3K3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Binding constant for MAP3K3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "11184",
"properties": {
"id": "crizotinib targets MAP4K1",
"source_label": "crizotinib",
"target_label": "MAP4K1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.41",
"act_comment": "Binding constant for HPK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "5871",
"properties": {
"id": "crizotinib targets MAP4K2",
"source_label": "crizotinib",
"target_label": "MAP4K2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "Binding constant for MAP4K2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "8491",
"properties": {
"id": "crizotinib targets MAP4K3",
"source_label": "crizotinib",
"target_label": "MAP4K3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.12",
"act_comment": "Binding constant for MAP4K3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "11183",
"properties": {
"id": "crizotinib targets MAP4K5",
"source_label": "crizotinib",
"target_label": "MAP4K5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "Binding constant for MAP4K5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "5598",
"properties": {
"id": "crizotinib targets MAPK7",
"source_label": "crizotinib",
"target_label": "MAPK7",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "Binding constant for ERK5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "10461",
"properties": {
"id": "crizotinib targets MERTK",
"source_label": "crizotinib",
"target_label": "MERTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.44",
"act_comment": "Binding constant for MERTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "4233",
"properties": {
"id": "crizotinib targets MET",
"source_label": "crizotinib",
"target_label": "MET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.26",
"act_comment": "Binding constant for MET(M1250T) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "197259",
"properties": {
"id": "crizotinib targets MLKL",
"source_label": "crizotinib",
"target_label": "MLKL",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Binding affinity to human MLKL by kinome scan based method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "4486",
"properties": {
"id": "crizotinib targets MST1R",
"source_label": "crizotinib",
"target_label": "MST1R",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "Binding constant for MST1R kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "4593",
"properties": {
"id": "crizotinib targets MUSK",
"source_label": "crizotinib",
"target_label": "MUSK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Binding constant for MUSK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "91754",
"properties": {
"id": "crizotinib targets NEK9",
"source_label": "crizotinib",
"target_label": "NEK9",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Binding constant for NEK9 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "4914",
"properties": {
"id": "crizotinib targets NTRK1",
"source_label": "crizotinib",
"target_label": "NTRK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.02",
"act_comment": "Binding constant for TRKA kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "4915",
"properties": {
"id": "crizotinib targets NTRK2",
"source_label": "crizotinib",
"target_label": "NTRK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.43",
"act_comment": "Binding constant for TRKB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "4916",
"properties": {
"id": "crizotinib targets NTRK3",
"source_label": "crizotinib",
"target_label": "NTRK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.09",
"act_comment": "Binding constant for TRKC kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "81788",
"properties": {
"id": "crizotinib targets NUAK2",
"source_label": "crizotinib",
"target_label": "NUAK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Binding constant for SNARK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "10733",
"properties": {
"id": "crizotinib targets PLK4",
"source_label": "crizotinib",
"target_label": "PLK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.22",
"act_comment": "Binding constant for PLK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "5587",
"properties": {
"id": "crizotinib targets PRKD1",
"source_label": "crizotinib",
"target_label": "PRKD1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for PRKD1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "23683",
"properties": {
"id": "crizotinib targets PRKD3",
"source_label": "crizotinib",
"target_label": "PRKD3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "Binding constant for PRKD3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "5747",
"properties": {
"id": "crizotinib targets PTK2",
"source_label": "crizotinib",
"target_label": "PTK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "Binding constant for FAK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "2185",
"properties": {
"id": "crizotinib targets PTK2B",
"source_label": "crizotinib",
"target_label": "PTK2B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Binding constant for PYK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "crizotinib targets RIPK2",
"source_label": "crizotinib",
"target_label": "RIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Binding constant for RIPK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "6098",
"properties": {
"id": "crizotinib targets ROS1",
"source_label": "crizotinib",
"target_label": "ROS1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.39",
"act_comment": "Binding constant for ROS1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "6198",
"properties": {
"id": "crizotinib targets RPS6KB1",
"source_label": "crizotinib",
"target_label": "RPS6KB1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Binding constant for S6K1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "100130827",
"properties": {
"id": "crizotinib targets SBK3",
"source_label": "crizotinib",
"target_label": "SBK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding constant for SgK110 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "23235",
"properties": {
"id": "crizotinib targets SIK2",
"source_label": "crizotinib",
"target_label": "SIK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Binding constant for SIK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "9748",
"properties": {
"id": "crizotinib targets SLK",
"source_label": "crizotinib",
"target_label": "SLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.74",
"act_comment": "Binding constant for SLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "6714",
"properties": {
"id": "crizotinib targets SRC",
"source_label": "crizotinib",
"target_label": "SRC",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "Binding constant for SRC kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "6793",
"properties": {
"id": "crizotinib targets STK10",
"source_label": "crizotinib",
"target_label": "STK10",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.36",
"act_comment": "Binding constant for LOK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "6788",
"properties": {
"id": "crizotinib targets STK3",
"source_label": "crizotinib",
"target_label": "STK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for MST2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "140901",
"properties": {
"id": "crizotinib targets STK35",
"source_label": "crizotinib",
"target_label": "STK35",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Binding constant for STK35 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "6789",
"properties": {
"id": "crizotinib targets STK4",
"source_label": "crizotinib",
"target_label": "STK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Binding constant for MST1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "9344",
"properties": {
"id": "crizotinib targets TAOK2",
"source_label": "crizotinib",
"target_label": "TAOK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Binding constant for TAOK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "51347",
"properties": {
"id": "crizotinib targets TAOK3",
"source_label": "crizotinib",
"target_label": "TAOK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.31",
"act_comment": "Binding constant for TAOK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "29110",
"properties": {
"id": "crizotinib targets TBK1",
"source_label": "crizotinib",
"target_label": "TBK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "Binding constant for TBK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "7010",
"properties": {
"id": "crizotinib targets TEK",
"source_label": "crizotinib",
"target_label": "TEK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Binding constant for TIE2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "7016",
"properties": {
"id": "crizotinib targets TESK1",
"source_label": "crizotinib",
"target_label": "TESK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Binding constant for TESK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "7046",
"properties": {
"id": "crizotinib targets TGFBR1",
"source_label": "crizotinib",
"target_label": "TGFBR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for TGFBR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "7075",
"properties": {
"id": "crizotinib targets TIE1",
"source_label": "crizotinib",
"target_label": "TIE1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Binding constant for TIE1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "8711",
"properties": {
"id": "crizotinib targets TNK1",
"source_label": "crizotinib",
"target_label": "TNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.49",
"act_comment": "Binding constant for TNK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "10188",
"properties": {
"id": "crizotinib targets TNK2",
"source_label": "crizotinib",
"target_label": "TNK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Binding constant for TNK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "51086",
"properties": {
"id": "crizotinib targets TNNI3K",
"source_label": "crizotinib",
"target_label": "TNNI3K",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Binding constant for TNNI3K kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "7294",
"properties": {
"id": "crizotinib targets TXK",
"source_label": "crizotinib",
"target_label": "TXK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "Binding constant for TXK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "7297",
"properties": {
"id": "crizotinib targets TYK2",
"source_label": "crizotinib",
"target_label": "TYK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Binding constant for TYK2(JH1domain-catalytic) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "7301",
"properties": {
"id": "crizotinib targets TYRO3",
"source_label": "crizotinib",
"target_label": "TYRO3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Binding constant for TYRO3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "8408",
"properties": {
"id": "crizotinib targets ULK1",
"source_label": "crizotinib",
"target_label": "ULK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for ULK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11626560",
"relation": "IDG (Drug Target)",
"target": "7525",
"properties": {
"id": "crizotinib targets YES1",
"source_label": "crizotinib",
"target_label": "YES1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Binding constant for YES kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:169870",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "hydroxyprogesterone caproate targets NR3C1",
"source_label": "hydroxyprogesterone caproate",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.638",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:169870",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "hydroxyprogesterone caproate targets PGR",
"source_label": "hydroxyprogesterone caproate",
"target_label": "PGR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.664",
"act_comment": "human recombinant PR-B isoform in Sf9 cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:169870",
"relation": "IDG (Drug Target)",
"target": "866",
"properties": {
"id": "hydroxyprogesterone caproate targets SERPINA6",
"source_label": "hydroxyprogesterone caproate",
"target_label": "SERPINA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.74",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:169870",
"relation": "IDG (Drug Target)",
"target": "6462",
"properties": {
"id": "hydroxyprogesterone caproate targets SHBG",
"source_label": "hydroxyprogesterone caproate",
"target_label": "SHBG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "22848",
"properties": {
"id": "ruxolitinib targets AAK1",
"source_label": "ruxolitinib",
"target_label": "AAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Binding constant for AAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "255239",
"properties": {
"id": "ruxolitinib targets ANKK1",
"source_label": "ruxolitinib",
"target_label": "ANKK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "Binding constant for ANKK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "55589",
"properties": {
"id": "ruxolitinib targets BMP2K",
"source_label": "ruxolitinib",
"target_label": "BMP2K",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Binding constant for BIKE kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "659",
"properties": {
"id": "ruxolitinib targets BMPR2",
"source_label": "ruxolitinib",
"target_label": "BMPR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "Binding constant for BMPR2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "8536",
"properties": {
"id": "ruxolitinib targets CAMK1",
"source_label": "ruxolitinib",
"target_label": "CAMK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Binding constant for CAMK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "57118",
"properties": {
"id": "ruxolitinib targets CAMK1D",
"source_label": "ruxolitinib",
"target_label": "CAMK1D",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Binding constant for CAMK1D kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "815",
"properties": {
"id": "ruxolitinib targets CAMK2A",
"source_label": "ruxolitinib",
"target_label": "CAMK2A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.34",
"act_comment": "Binding constant for CAMK2A kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "816",
"properties": {
"id": "ruxolitinib targets CAMK2B",
"source_label": "ruxolitinib",
"target_label": "CAMK2B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "Binding constant for CAMK2B kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "817",
"properties": {
"id": "ruxolitinib targets CAMK2D",
"source_label": "ruxolitinib",
"target_label": "CAMK2D",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.05",
"act_comment": "Binding constant for CAMK2D kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "818",
"properties": {
"id": "ruxolitinib targets CAMK2G",
"source_label": "ruxolitinib",
"target_label": "CAMK2G",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Binding constant for CAMK2G kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "814",
"properties": {
"id": "ruxolitinib targets CAMK4",
"source_label": "ruxolitinib",
"target_label": "CAMK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.71",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "1196",
"properties": {
"id": "ruxolitinib targets CLK2",
"source_label": "ruxolitinib",
"target_label": "CLK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.34",
"act_comment": "Binding constant for CLK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "53944",
"properties": {
"id": "ruxolitinib targets CSNK1G1",
"source_label": "ruxolitinib",
"target_label": "CSNK1G1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "1612",
"properties": {
"id": "ruxolitinib targets DAPK1",
"source_label": "ruxolitinib",
"target_label": "DAPK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.14",
"act_comment": "Binding constant for DAPK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "23604",
"properties": {
"id": "ruxolitinib targets DAPK2",
"source_label": "ruxolitinib",
"target_label": "DAPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.01",
"act_comment": "Binding constant for DAPK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "1613",
"properties": {
"id": "ruxolitinib targets DAPK3",
"source_label": "ruxolitinib",
"target_label": "DAPK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.05",
"act_comment": "Binding constant for DAPK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "9201",
"properties": {
"id": "ruxolitinib targets DCLK1",
"source_label": "ruxolitinib",
"target_label": "DCLK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.17",
"act_comment": "Binding constant for DCAMKL1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "166614",
"properties": {
"id": "ruxolitinib targets DCLK2",
"source_label": "ruxolitinib",
"target_label": "DCLK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Binding constant for DCAMKL2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "85443",
"properties": {
"id": "ruxolitinib targets DCLK3",
"source_label": "ruxolitinib",
"target_label": "DCLK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "Binding constant for DCAMKL3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "1859",
"properties": {
"id": "ruxolitinib targets DYRK1A",
"source_label": "ruxolitinib",
"target_label": "DYRK1A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "Binding constant for DYRK1A kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "2580",
"properties": {
"id": "ruxolitinib targets GAK",
"source_label": "ruxolitinib",
"target_label": "GAK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Binding constant for GAK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "6011",
"properties": {
"id": "ruxolitinib targets GRK1",
"source_label": "ruxolitinib",
"target_label": "GRK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Binding constant for GRK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "131890",
"properties": {
"id": "ruxolitinib targets GRK7",
"source_label": "ruxolitinib",
"target_label": "GRK7",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.27",
"act_comment": "Binding constant for GRK7 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "10013",
"properties": {
"id": "ruxolitinib targets HDAC6",
"source_label": "ruxolitinib",
"target_label": "HDAC6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.82",
"act_comment": "Inhibition of recombinant human HDAC6 using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "28996",
"properties": {
"id": "ruxolitinib targets HIPK2",
"source_label": "ruxolitinib",
"target_label": "HIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for HIPK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "3654",
"properties": {
"id": "ruxolitinib targets IRAK1",
"source_label": "ruxolitinib",
"target_label": "IRAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Binding constant for IRAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "3716",
"properties": {
"id": "ruxolitinib targets JAK1",
"source_label": "ruxolitinib",
"target_label": "JAK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.05",
"act_comment": "Inhibition of purified JAK1 incubated for 30 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "3717",
"properties": {
"id": "ruxolitinib targets JAK2",
"source_label": "ruxolitinib",
"target_label": "JAK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "10.44",
"act_comment": "Binding constant for JAK2(JH1domain-catalytic) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "3718",
"properties": {
"id": "ruxolitinib targets JAK3",
"source_label": "ruxolitinib",
"target_label": "JAK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "Binding constant for JAK3(JH1domain-catalytic) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "120892",
"properties": {
"id": "ruxolitinib targets LRRK2",
"source_label": "ruxolitinib",
"target_label": "LRRK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.05",
"act_comment": "Binding constant for LRRK2(G2019S) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "4058",
"properties": {
"id": "ruxolitinib targets LTK",
"source_label": "ruxolitinib",
"target_label": "LTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Binding constant for LTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "5606",
"properties": {
"id": "ruxolitinib targets MAP2K3",
"source_label": "ruxolitinib",
"target_label": "MAP2K3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Binding constant for MEK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "80122",
"properties": {
"id": "ruxolitinib targets MAP3K19",
"source_label": "ruxolitinib",
"target_label": "MAP3K19",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Binding constant for YSK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "10746",
"properties": {
"id": "ruxolitinib targets MAP3K2",
"source_label": "ruxolitinib",
"target_label": "MAP3K2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.39",
"act_comment": "Binding constant for MAP3K2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "4215",
"properties": {
"id": "ruxolitinib targets MAP3K3",
"source_label": "ruxolitinib",
"target_label": "MAP3K3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "Binding constant for MAP3K3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "6885",
"properties": {
"id": "ruxolitinib targets MAP3K7",
"source_label": "ruxolitinib",
"target_label": "MAP3K7",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Binding constant for TAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "2011",
"properties": {
"id": "ruxolitinib targets MARK2",
"source_label": "ruxolitinib",
"target_label": "MARK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.18",
"act_comment": "Binding constant for MARK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "22983",
"properties": {
"id": "ruxolitinib targets MAST1",
"source_label": "ruxolitinib",
"target_label": "MAST1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Binding constant for MAST1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "2872",
"properties": {
"id": "ruxolitinib targets MKNK2",
"source_label": "ruxolitinib",
"target_label": "MKNK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Binding constant for MKNK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "4638",
"properties": {
"id": "ruxolitinib targets MYLK",
"source_label": "ruxolitinib",
"target_label": "MYLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Binding constant for MYLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "4915",
"properties": {
"id": "ruxolitinib targets NTRK2",
"source_label": "ruxolitinib",
"target_label": "NTRK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Binding constant for TRKB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "4916",
"properties": {
"id": "ruxolitinib targets NTRK3",
"source_label": "ruxolitinib",
"target_label": "NTRK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Binding constant for TRKC kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "81788",
"properties": {
"id": "ruxolitinib targets NUAK2",
"source_label": "ruxolitinib",
"target_label": "NUAK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.49",
"act_comment": "Binding constant for SNARK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "5261",
"properties": {
"id": "ruxolitinib targets PHKG2",
"source_label": "ruxolitinib",
"target_label": "PHKG2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for PHKG2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "5347",
"properties": {
"id": "ruxolitinib targets PLK1",
"source_label": "ruxolitinib",
"target_label": "PLK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Binding constant for PLK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "1263",
"properties": {
"id": "ruxolitinib targets PLK3",
"source_label": "ruxolitinib",
"target_label": "PLK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Binding constant for PLK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "10733",
"properties": {
"id": "ruxolitinib targets PLK4",
"source_label": "ruxolitinib",
"target_label": "PLK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Binding constant for PLK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "5581",
"properties": {
"id": "ruxolitinib targets PRKCE",
"source_label": "ruxolitinib",
"target_label": "PRKCE",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Binding constant for PRKCE kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "5593",
"properties": {
"id": "ruxolitinib targets PRKG2",
"source_label": "ruxolitinib",
"target_label": "PRKG2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "Binding constant for PRKG2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "ruxolitinib targets RET",
"source_label": "ruxolitinib",
"target_label": "RET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Binding constant for RET(V804M) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "6093",
"properties": {
"id": "ruxolitinib targets ROCK1",
"source_label": "ruxolitinib",
"target_label": "ROCK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.22",
"act_comment": "Binding constant for ROCK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "9475",
"properties": {
"id": "ruxolitinib targets ROCK2",
"source_label": "ruxolitinib",
"target_label": "ROCK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.28",
"act_comment": "Binding constant for ROCK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "6195",
"properties": {
"id": "ruxolitinib targets RPS6KA1",
"source_label": "ruxolitinib",
"target_label": "RPS6KA1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Binding constant for RSK1(Kin.Dom.2-C-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "6196",
"properties": {
"id": "ruxolitinib targets RPS6KA2",
"source_label": "ruxolitinib",
"target_label": "RPS6KA2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "Binding constant for RSK3(Kin.Dom.2-C-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "8986",
"properties": {
"id": "ruxolitinib targets RPS6KA4",
"source_label": "ruxolitinib",
"target_label": "RPS6KA4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "Binding constant for RPS6KA4(Kin.Dom.2-C-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "9252",
"properties": {
"id": "ruxolitinib targets RPS6KA5",
"source_label": "ruxolitinib",
"target_label": "RPS6KA5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Binding constant for RPS6KA5(Kin.Dom.2-C-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "27330",
"properties": {
"id": "ruxolitinib targets RPS6KA6",
"source_label": "ruxolitinib",
"target_label": "RPS6KA6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "Binding constant for RSK4(Kin.Dom.2-C-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "8576",
"properties": {
"id": "ruxolitinib targets STK16",
"source_label": "ruxolitinib",
"target_label": "STK16",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.31",
"act_comment": "Binding constant for STK16 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "9344",
"properties": {
"id": "ruxolitinib targets TAOK2",
"source_label": "ruxolitinib",
"target_label": "TAOK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "Binding constant for TAOK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "51347",
"properties": {
"id": "ruxolitinib targets TAOK3",
"source_label": "ruxolitinib",
"target_label": "TAOK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.23",
"act_comment": "Binding constant for TAOK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "7272",
"properties": {
"id": "ruxolitinib targets TTK",
"source_label": "ruxolitinib",
"target_label": "TTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.32",
"act_comment": "Binding constant for TTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "7297",
"properties": {
"id": "ruxolitinib targets TYK2",
"source_label": "ruxolitinib",
"target_label": "TYK2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "Inhibition of TYK2 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "8408",
"properties": {
"id": "ruxolitinib targets ULK1",
"source_label": "ruxolitinib",
"target_label": "ULK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Binding constant for ULK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25126798",
"relation": "IDG (Drug Target)",
"target": "9706",
"properties": {
"id": "ruxolitinib targets ULK2",
"source_label": "ruxolitinib",
"target_label": "ULK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Binding constant for ULK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918558",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "fesoterodine targets CHRM1",
"source_label": "fesoterodine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.393",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6918558",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "fesoterodine targets CHRM2",
"source_label": "fesoterodine",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.401",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6918558",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "fesoterodine targets CHRM3",
"source_label": "fesoterodine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.271",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6918558",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "fesoterodine targets CHRM4",
"source_label": "fesoterodine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.187",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:11001318",
"relation": "IDG (Drug Target)",
"target": "7276",
"properties": {
"id": "tafamidis targets TTR",
"source_label": "tafamidis",
"target_label": "TTR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.812",
"act_comment": "Mechanism of Action",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:5280531",
"relation": "IDG (Drug Target)",
"target": "5950",
"properties": {
"id": "vitamin A palmitate targets RBP4",
"source_label": "vitamin A palmitate",
"target_label": "RBP4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4893",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "prazosin targets ADORA3",
"source_label": "prazosin",
"target_label": "ADORA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.07",
"act_comment": "Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4893",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "prazosin targets ADRA1A",
"source_label": "prazosin",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.4",
"act_comment": "Displacement of [3H]prazosin from human recombinant alpha1A adrenoceptor expressed in CHO cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4893",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "prazosin targets ADRA1B",
"source_label": "prazosin",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.68",
"act_comment": "Ability to displace [3H]prazosin from cloned human Alpha-1B adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4893",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "prazosin targets ADRA1D",
"source_label": "prazosin",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4893",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "prazosin targets ADRA2A",
"source_label": "prazosin",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4893",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "prazosin targets ADRA2B",
"source_label": "prazosin",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Ability to displace [3H]rauwolscine from cloned human Alpha-2B adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4893",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "prazosin targets ADRA2C",
"source_label": "prazosin",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.62",
"act_comment": "Ability to displace [3H]rauwolscine from cloned human Alpha-2C adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4893",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "prazosin targets HTR1D",
"source_label": "prazosin",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.48",
"act_comment": "Binding affinity was determined for the alpha-1D adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:4893",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "prazosin targets HTR2A",
"source_label": "prazosin",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.73",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:4893",
"relation": "IDG (Drug Target)",
"target": "4835",
"properties": {
"id": "prazosin targets NQO2",
"source_label": "prazosin",
"target_label": "NQO2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.11",
"act_comment": "Binding affinity to low affinity melatonin (MT3) site of quinone reductase 2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176",
"relation": "IDG (Drug Target)",
"target": "2534",
"properties": {
"id": "acetic acid targets FYN",
"source_label": "acetic acid",
"target_label": "FYN",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Dissociation constant for binding to SH2 domain of Fyn protein kinase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "acetic acid targets LCK",
"source_label": "acetic acid",
"target_label": "LCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Dissociation constant for binding to SH2 domain of p56 lck tyrosine kinase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5744",
"relation": "IDG (Drug Target)",
"target": "866",
"properties": {
"id": "hydrocortisone acetate targets SERPINA6",
"source_label": "hydrocortisone acetate",
"target_label": "SERPINA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.55",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918314",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "vilazodone targets DRD2",
"source_label": "vilazodone",
"target_label": "DRD2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.18",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6918314",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "vilazodone targets DRD3",
"source_label": "vilazodone",
"target_label": "DRD3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6918314",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "vilazodone targets HRH1",
"source_label": "vilazodone",
"target_label": "HRH1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6918314",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "vilazodone targets HTR1A",
"source_label": "vilazodone",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "Binding of vilazodone to human 5-HT1A receptors against [3H]8-OH-DPAT (DPAT)",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6918314",
"relation": "IDG (Drug Target)",
"target": "3360",
"properties": {
"id": "vilazodone targets HTR4",
"source_label": "vilazodone",
"target_label": "HTR4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6918314",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "vilazodone targets SLC6A4",
"source_label": "vilazodone",
"target_label": "SLC6A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "axitinib targets ABL1",
"source_label": "axitinib",
"target_label": "ABL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.82",
"act_comment": "Binding constant for ABL1(T315I)-phosphorylated kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "27",
"properties": {
"id": "axitinib targets ABL2",
"source_label": "axitinib",
"target_label": "ABL2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "Binding constant for ABL2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "6790",
"properties": {
"id": "axitinib targets AURKA",
"source_label": "axitinib",
"target_label": "AURKA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.14",
"act_comment": "Binding constant for AURKA kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "9212",
"properties": {
"id": "axitinib targets AURKB",
"source_label": "axitinib",
"target_label": "AURKB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Binding constant for AURKB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "6795",
"properties": {
"id": "axitinib targets AURKC",
"source_label": "axitinib",
"target_label": "AURKC",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.89",
"act_comment": "Binding constant for AURKC kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "558",
"properties": {
"id": "axitinib targets AXL",
"source_label": "axitinib",
"target_label": "AXL",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Binding constant for AXL kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "613",
"properties": {
"id": "axitinib targets BCR",
"source_label": "axitinib",
"target_label": "BCR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.73",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "55589",
"properties": {
"id": "axitinib targets BMP2K",
"source_label": "axitinib",
"target_label": "BMP2K",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for BIKE kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "8999",
"properties": {
"id": "axitinib targets CDKL2",
"source_label": "axitinib",
"target_label": "CDKL2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Binding constant for CDKL2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "1436",
"properties": {
"id": "axitinib targets CSF1R",
"source_label": "axitinib",
"target_label": "CSF1R",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.68",
"act_comment": "Binding constant for CSF1R kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "780",
"properties": {
"id": "axitinib targets DDR1",
"source_label": "axitinib",
"target_label": "DDR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "Binding constant for DDR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "2051",
"properties": {
"id": "axitinib targets EPHB6",
"source_label": "axitinib",
"target_label": "EPHB6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Binding constant for EPHB6 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "2260",
"properties": {
"id": "axitinib targets FGFR1",
"source_label": "axitinib",
"target_label": "FGFR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Binding constant for FGFR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "2263",
"properties": {
"id": "axitinib targets FGFR2",
"source_label": "axitinib",
"target_label": "FGFR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Binding constant for FGFR2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "2261",
"properties": {
"id": "axitinib targets FGFR3",
"source_label": "axitinib",
"target_label": "FGFR3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Binding constant for FGFR3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "2321",
"properties": {
"id": "axitinib targets FLT1",
"source_label": "axitinib",
"target_label": "FLT1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.24",
"act_comment": "Binding constant for FLT1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "axitinib targets FLT3",
"source_label": "axitinib",
"target_label": "FLT3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.51",
"act_comment": "Binding constant for FLT3(K663Q) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "2324",
"properties": {
"id": "axitinib targets FLT4",
"source_label": "axitinib",
"target_label": "FLT4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Binding constant for FLT4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "axitinib targets KDR",
"source_label": "axitinib",
"target_label": "KDR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.23",
"act_comment": "Binding constant for VEGFR2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "axitinib targets KIT",
"source_label": "axitinib",
"target_label": "KIT",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.31",
"act_comment": "Binding constant for KIT(V559D) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "120892",
"properties": {
"id": "axitinib targets LRRK2",
"source_label": "axitinib",
"target_label": "LRRK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "Binding constant for LRRK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "5607",
"properties": {
"id": "axitinib targets MAP2K5",
"source_label": "axitinib",
"target_label": "MAP2K5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Binding constant for MEK5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "80122",
"properties": {
"id": "axitinib targets MAP3K19",
"source_label": "axitinib",
"target_label": "MAP3K19",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Binding constant for YSK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "11184",
"properties": {
"id": "axitinib targets MAP4K1",
"source_label": "axitinib",
"target_label": "MAP4K1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Binding constant for HPK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "9448",
"properties": {
"id": "axitinib targets MAP4K4",
"source_label": "axitinib",
"target_label": "MAP4K4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Binding constant for MAP4K4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "11183",
"properties": {
"id": "axitinib targets MAP4K5",
"source_label": "axitinib",
"target_label": "MAP4K5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "Binding constant for MAP4K5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "4233",
"properties": {
"id": "axitinib targets MET",
"source_label": "axitinib",
"target_label": "MET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Binding constant for MET kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "50488",
"properties": {
"id": "axitinib targets MINK1",
"source_label": "axitinib",
"target_label": "MINK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "Binding constant for MINK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "5156",
"properties": {
"id": "axitinib targets PDGFRA",
"source_label": "axitinib",
"target_label": "PDGFRA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.29",
"act_comment": "Binding constant for PDGFRA kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "axitinib targets PDGFRB",
"source_label": "axitinib",
"target_label": "PDGFRB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.24",
"act_comment": "Binding constant for PDGFRB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "10733",
"properties": {
"id": "axitinib targets PLK4",
"source_label": "axitinib",
"target_label": "PLK4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.38",
"act_comment": "Inhibition of human PLK4",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "axitinib targets RET",
"source_label": "axitinib",
"target_label": "RET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Binding constant for RET(M918T) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "8780",
"properties": {
"id": "axitinib targets RIOK3",
"source_label": "axitinib",
"target_label": "RIOK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for RIOK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "9748",
"properties": {
"id": "axitinib targets SLK",
"source_label": "axitinib",
"target_label": "SLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for SLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "8576",
"properties": {
"id": "axitinib targets STK16",
"source_label": "axitinib",
"target_label": "STK16",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.43",
"act_comment": "Binding constant for STK16 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "7010",
"properties": {
"id": "axitinib targets TEK",
"source_label": "axitinib",
"target_label": "TEK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "Binding constant for TIE2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "7075",
"properties": {
"id": "axitinib targets TIE1",
"source_label": "axitinib",
"target_label": "TIE1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.01",
"act_comment": "Binding constant for TIE1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "23043",
"properties": {
"id": "axitinib targets TNIK",
"source_label": "axitinib",
"target_label": "TNIK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Binding constant for TNIK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "8711",
"properties": {
"id": "axitinib targets TNK1",
"source_label": "axitinib",
"target_label": "TNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "Binding constant for TNK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6450551",
"relation": "IDG (Drug Target)",
"target": "25989",
"properties": {
"id": "axitinib targets ULK3",
"source_label": "axitinib",
"target_label": "ULK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Binding constant for ULK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918670",
"relation": "IDG (Drug Target)",
"target": "5578",
"properties": {
"id": "ingenol mebutate targets PRKCA",
"source_label": "ingenol mebutate",
"target_label": "PRKCA",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.197",
"act_comment": "Colo-205 cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:6918670",
"relation": "IDG (Drug Target)",
"target": "5579",
"properties": {
"id": "ingenol mebutate targets PRKCB",
"source_label": "ingenol mebutate",
"target_label": "PRKCB",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.836",
"act_comment": "Colo-205 cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:6918670",
"relation": "IDG (Drug Target)",
"target": "5580",
"properties": {
"id": "ingenol mebutate targets PRKCD",
"source_label": "ingenol mebutate",
"target_label": "PRKCD",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.328",
"act_comment": "Colo-205 cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:6918670",
"relation": "IDG (Drug Target)",
"target": "5581",
"properties": {
"id": "ingenol mebutate targets PRKCE",
"source_label": "ingenol mebutate",
"target_label": "PRKCE",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.959",
"act_comment": "Colo-205 cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:6918670",
"relation": "IDG (Drug Target)",
"target": "5582",
"properties": {
"id": "ingenol mebutate targets PRKCG",
"source_label": "ingenol mebutate",
"target_label": "PRKCG",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.79",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6918670",
"relation": "IDG (Drug Target)",
"target": "5587",
"properties": {
"id": "ingenol mebutate targets PRKD1",
"source_label": "ingenol mebutate",
"target_label": "PRKD1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.523",
"act_comment": "Colo-205 cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24776445",
"relation": "IDG (Drug Target)",
"target": "6469",
"properties": {
"id": "vismodegib targets SHH",
"source_label": "vismodegib",
"target_label": "SHH",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.82",
"act_comment": "Inhibition of human SHH pathway in mouse S12 cells assessed as GLI-mediated transcriptional activity after 48 hrs by luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24776445",
"relation": "IDG (Drug Target)",
"target": "6608",
"properties": {
"id": "vismodegib targets SMO",
"source_label": "vismodegib",
"target_label": "SMO",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.79",
"act_comment": "Displacement of [3H]cyclopamine from wild type Smo expressed in U2OS cells after 2 hrs by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16220172",
"relation": "IDG (Drug Target)",
"target": "1080",
"properties": {
"id": "ivacaftor targets CFTR",
"source_label": "ivacaftor",
"target_label": "CFTR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3086674",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "Ioflupane I-123 targets SLC6A3",
"source_label": "Ioflupane I-123",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.21",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:402",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "sulfur targets CA1",
"source_label": "sulfur",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1176",
"relation": "IDG (Drug Target)",
"target": "81285",
"properties": {
"id": "carbamide targets OR51E2",
"source_label": "carbamide",
"target_label": "OR51E2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.64",
"act_comment": "Agonist activity at PSGR/OR51E2 (unknown origin) expressed in human Hana3A cells co-transfected with CRE-Luc by luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:14985",
"relation": "IDG (Drug Target)",
"target": "2950",
"properties": {
"id": "tocofersolan targets GSTP1",
"source_label": "tocofersolan",
"target_label": "GSTP1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Inhibition of human GSTP1-1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9838022",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "tapentadol targets OPRM1",
"source_label": "tapentadol",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.018",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9838022",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "tapentadol targets SLC6A2",
"source_label": "tapentadol",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.319",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:24822371",
"relation": "IDG (Drug Target)",
"target": "351",
"properties": {
"id": "Florbetapir F-18 targets APP",
"source_label": "Florbetapir F-18",
"target_label": "APP",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.54",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:445580",
"relation": "IDG (Drug Target)",
"target": "2864",
"properties": {
"id": "doconexent targets FFAR1",
"source_label": "doconexent",
"target_label": "FFAR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:10182969",
"relation": "IDG (Drug Target)",
"target": "2159",
"properties": {
"id": "apixaban targets F10",
"source_label": "apixaban",
"target_label": "F10",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.1",
"act_comment": "Inhibition of human factor 10a",
"act_source": "CHEMBL"
}
},
{
"source": "CID:15950376",
"relation": "IDG (Drug Target)",
"target": "351",
"properties": {
"id": "Flutemetamol (18F) targets APP",
"source_label": "Flutemetamol (18F)",
"target_label": "APP",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.15",
"act_comment": "Binding affinity to human amyloid beta plaque",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3494",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "glycopyrronium bromide targets CHRM1",
"source_label": "glycopyrronium bromide",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.69",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:3494",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "glycopyrronium bromide targets CHRM2",
"source_label": "glycopyrronium bromide",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.25",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:3494",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "glycopyrronium bromide targets CHRM3",
"source_label": "glycopyrronium bromide",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.64",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:3494",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "glycopyrronium bromide targets CHRM4",
"source_label": "glycopyrronium bromide",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.06",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:3494",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "glycopyrronium bromide targets CHRM5",
"source_label": "glycopyrronium bromide",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.91",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9887712",
"relation": "IDG (Drug Target)",
"target": "6523",
"properties": {
"id": "dapagliflozin targets SLC5A1",
"source_label": "dapagliflozin",
"target_label": "SLC5A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.49",
"act_comment": "Inhibition of human SGLT2 expressed in african green monkey COS7 cells assessed as inhibition of [14C]-methyl-alpha-D-glucopyranoside uptake after 2 hrs by scintillation counting in presence of 25 % human plasma",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9887712",
"relation": "IDG (Drug Target)",
"target": "115584",
"properties": {
"id": "dapagliflozin targets SLC5A11",
"source_label": "dapagliflozin",
"target_label": "SLC5A11",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Inhibition of SGLT6 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9887712",
"relation": "IDG (Drug Target)",
"target": "6524",
"properties": {
"id": "dapagliflozin targets SLC5A2",
"source_label": "dapagliflozin",
"target_label": "SLC5A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9887712",
"relation": "IDG (Drug Target)",
"target": "6527",
"properties": {
"id": "dapagliflozin targets SLC5A4",
"source_label": "dapagliflozin",
"target_label": "SLC5A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.87",
"act_comment": "Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9869929",
"relation": "IDG (Drug Target)",
"target": "8654",
"properties": {
"id": "avanafil targets PDE5A",
"source_label": "avanafil",
"target_label": "PDE5A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.284",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9869929",
"relation": "IDG (Drug Target)",
"target": "5146",
"properties": {
"id": "avanafil targets PDE6C",
"source_label": "avanafil",
"target_label": "PDE6C",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.201",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9909681",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "lasofoxifene targets ESR1",
"source_label": "lasofoxifene",
"target_label": "ESR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.89",
"act_comment": "Binding affinity for human estrogen receptor alpha",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9909681",
"relation": "IDG (Drug Target)",
"target": "2100",
"properties": {
"id": "lasofoxifene targets ESR2",
"source_label": "lasofoxifene",
"target_label": "ESR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.74",
"act_comment": "Binding affinity for human estrogen receptor beta",
"act_source": "CHEMBL"
}
},
{
"source": "CID:219078",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "lacosamide targets CA1",
"source_label": "lacosamide",
"target_label": "CA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Inhibition of human recombinant CA1 by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:219078",
"relation": "IDG (Drug Target)",
"target": "23632",
"properties": {
"id": "lacosamide targets CA14",
"source_label": "lacosamide",
"target_label": "CA14",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Inhibition of human recombinant CA14 by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:219078",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "lacosamide targets CA2",
"source_label": "lacosamide",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Inhibition of human recombinant CA2 by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:219078",
"relation": "IDG (Drug Target)",
"target": "761",
"properties": {
"id": "lacosamide targets CA3",
"source_label": "lacosamide",
"target_label": "CA3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.43",
"act_comment": "Inhibition of human recombinant CA3 by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:219078",
"relation": "IDG (Drug Target)",
"target": "762",
"properties": {
"id": "lacosamide targets CA4",
"source_label": "lacosamide",
"target_label": "CA4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Inhibition of human recombinant CA4 by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:219078",
"relation": "IDG (Drug Target)",
"target": "11238",
"properties": {
"id": "lacosamide targets CA5B",
"source_label": "lacosamide",
"target_label": "CA5B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "Inhibition of human recombinant CA5B by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:219078",
"relation": "IDG (Drug Target)",
"target": "765",
"properties": {
"id": "lacosamide targets CA6",
"source_label": "lacosamide",
"target_label": "CA6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "Inhibition of human recombinant CA6 by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:219078",
"relation": "IDG (Drug Target)",
"target": "768",
"properties": {
"id": "lacosamide targets CA9",
"source_label": "lacosamide",
"target_label": "CA9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.45",
"act_comment": "Inhibition of human recombinant CA9 by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:219078",
"relation": "IDG (Drug Target)",
"target": "6335",
"properties": {
"id": "lacosamide targets SCN9A",
"source_label": "lacosamide",
"target_label": "SCN9A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Binding affinity to human inactivated voltage-gated Na channel 1.7 expressed in HEK293 cells by patch-clamp technique",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10184653",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "afatinib targets ABL1",
"source_label": "afatinib",
"target_label": "ABL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Binding constant for ABL1(F317L)-phosphorylated kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10184653",
"relation": "IDG (Drug Target)",
"target": "640",
"properties": {
"id": "afatinib targets BLK",
"source_label": "afatinib",
"target_label": "BLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Binding constant for BLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10184653",
"relation": "IDG (Drug Target)",
"target": "1859",
"properties": {
"id": "afatinib targets DYRK1A",
"source_label": "afatinib",
"target_label": "DYRK1A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Binding constant for DYRK1A kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10184653",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "afatinib targets EGFR",
"source_label": "afatinib",
"target_label": "EGFR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "10.0",
"act_comment": "Binding constant for EGFR(G719C) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10184653",
"relation": "IDG (Drug Target)",
"target": "285220",
"properties": {
"id": "afatinib targets EPHA6",
"source_label": "afatinib",
"target_label": "EPHA6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "Binding constant for EPHA6 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10184653",
"relation": "IDG (Drug Target)",
"target": "2064",
"properties": {
"id": "afatinib targets ERBB2",
"source_label": "afatinib",
"target_label": "ERBB2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "Binding constant for ERBB2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10184653",
"relation": "IDG (Drug Target)",
"target": "2066",
"properties": {
"id": "afatinib targets ERBB4",
"source_label": "afatinib",
"target_label": "ERBB4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "Binding constant for ERBB4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10184653",
"relation": "IDG (Drug Target)",
"target": "2580",
"properties": {
"id": "afatinib targets GAK",
"source_label": "afatinib",
"target_label": "GAK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "Binding constant for GAK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10184653",
"relation": "IDG (Drug Target)",
"target": "147746",
"properties": {
"id": "afatinib targets HIPK4",
"source_label": "afatinib",
"target_label": "HIPK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Binding constant for HIPK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10184653",
"relation": "IDG (Drug Target)",
"target": "3654",
"properties": {
"id": "afatinib targets IRAK1",
"source_label": "afatinib",
"target_label": "IRAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding constant for IRAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10184653",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "afatinib targets LCK",
"source_label": "afatinib",
"target_label": "LCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Binding constant for LCK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10184653",
"relation": "IDG (Drug Target)",
"target": "9261",
"properties": {
"id": "afatinib targets MAPKAPK2",
"source_label": "afatinib",
"target_label": "MAPKAPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10184653",
"relation": "IDG (Drug Target)",
"target": "5261",
"properties": {
"id": "afatinib targets PHKG2",
"source_label": "afatinib",
"target_label": "PHKG2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Binding constant for PHKG2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:135409642",
"relation": "IDG (Drug Target)",
"target": "185",
"properties": {
"id": "azilsartan medoxomil targets AGTR1",
"source_label": "azilsartan medoxomil",
"target_label": "AGTR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.13",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9867642",
"relation": "IDG (Drug Target)",
"target": "5729",
"properties": {
"id": "laropiprant targets PTGDR",
"source_label": "laropiprant",
"target_label": "PTGDR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "10.52",
"act_comment": "Binding affinity to human DP receptor expressed in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9867642",
"relation": "IDG (Drug Target)",
"target": "11251",
"properties": {
"id": "laropiprant targets PTGDR2",
"source_label": "laropiprant",
"target_label": "PTGDR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "Activity at CRTH2 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9867642",
"relation": "IDG (Drug Target)",
"target": "5732",
"properties": {
"id": "laropiprant targets PTGER2",
"source_label": "laropiprant",
"target_label": "PTGER2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.87",
"act_comment": "Binding affinity to human EP2 receptor expressed in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9867642",
"relation": "IDG (Drug Target)",
"target": "5733",
"properties": {
"id": "laropiprant targets PTGER3",
"source_label": "laropiprant",
"target_label": "PTGER3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Binding affinity to human EP3 receptor expressed in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9867642",
"relation": "IDG (Drug Target)",
"target": "6915",
"properties": {
"id": "laropiprant targets TBXA2R",
"source_label": "laropiprant",
"target_label": "TBXA2R",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.53",
"act_comment": "Binding affinity to human TP receptor expressed in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9941444",
"relation": "IDG (Drug Target)",
"target": "6751",
"properties": {
"id": "pasireotide targets SSTR1",
"source_label": "pasireotide",
"target_label": "SSTR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9941444",
"relation": "IDG (Drug Target)",
"target": "6752",
"properties": {
"id": "pasireotide targets SSTR2",
"source_label": "pasireotide",
"target_label": "SSTR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9941444",
"relation": "IDG (Drug Target)",
"target": "6753",
"properties": {
"id": "pasireotide targets SSTR3",
"source_label": "pasireotide",
"target_label": "SSTR3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9941444",
"relation": "IDG (Drug Target)",
"target": "6755",
"properties": {
"id": "pasireotide targets SSTR5",
"source_label": "pasireotide",
"target_label": "SSTR5",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:154257",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "bazedoxifene targets ESR1",
"source_label": "bazedoxifene",
"target_label": "ESR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.22",
"act_comment": "Inhibition of binding to recombinant human ERalpha by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:154257",
"relation": "IDG (Drug Target)",
"target": "2100",
"properties": {
"id": "bazedoxifene targets ESR2",
"source_label": "bazedoxifene",
"target_label": "ESR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.42",
"act_comment": "Inhibition of binding to recombinant human ERbeta by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918493",
"relation": "IDG (Drug Target)",
"target": "1909",
"properties": {
"id": "ambrisentan targets EDNRA",
"source_label": "ambrisentan",
"target_label": "EDNRA",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.65",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:6918493",
"relation": "IDG (Drug Target)",
"target": "1910",
"properties": {
"id": "ambrisentan targets EDNRB",
"source_label": "ambrisentan",
"target_label": "EDNRB",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.98",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:11450633",
"relation": "IDG (Drug Target)",
"target": "1803",
"properties": {
"id": "alogliptin targets DPP4",
"source_label": "alogliptin",
"target_label": "DPP4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "Inhibition of DPP4 in human plasma assessed as formation of 7-amino-4-methylcoumarin from glycyl-L-proline 4-methylcoumaryl-7-amide by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1548942",
"relation": "IDG (Drug Target)",
"target": "7442",
"properties": {
"id": "zucapsaicin targets TRPV1",
"source_label": "zucapsaicin",
"target_label": "TRPV1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.71",
"act_comment": "increases in intracellular (HEK-293 cells) Ca2+ using Fluo-3 dye",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:185460",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "bilastine targets HRH1",
"source_label": "bilastine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.194",
"act_comment": "inhibition of [3H]-pyrilamine binding to human recombinant histamine H1-receptors",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "bosutinib targets ABL1",
"source_label": "bosutinib",
"target_label": "ABL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "10.54",
"act_comment": "Binding constant for ABL1(F317L)-phosphorylated kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "27",
"properties": {
"id": "bosutinib targets ABL2",
"source_label": "bosutinib",
"target_label": "ABL2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.82",
"act_comment": "Binding constant for ABL2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "238",
"properties": {
"id": "bosutinib targets ALK",
"source_label": "bosutinib",
"target_label": "ALK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "Binding constant for ALK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "558",
"properties": {
"id": "bosutinib targets AXL",
"source_label": "bosutinib",
"target_label": "AXL",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.28",
"act_comment": "Binding constant for AXL kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "640",
"properties": {
"id": "bosutinib targets BLK",
"source_label": "bosutinib",
"target_label": "BLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.48",
"act_comment": "Binding constant for BLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "55589",
"properties": {
"id": "bosutinib targets BMP2K",
"source_label": "bosutinib",
"target_label": "BMP2K",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Binding constant for BIKE kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "659",
"properties": {
"id": "bosutinib targets BMPR2",
"source_label": "bosutinib",
"target_label": "BMPR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Binding constant for BMPR2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "660",
"properties": {
"id": "bosutinib targets BMX",
"source_label": "bosutinib",
"target_label": "BMX",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Binding constant for BMX kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "695",
"properties": {
"id": "bosutinib targets BTK",
"source_label": "bosutinib",
"target_label": "BTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.32",
"act_comment": "Binding constant for BTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "57118",
"properties": {
"id": "bosutinib targets CAMK1D",
"source_label": "bosutinib",
"target_label": "CAMK1D",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "Binding constant for CAMK1D kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "10645",
"properties": {
"id": "bosutinib targets CAMKK2",
"source_label": "bosutinib",
"target_label": "CAMKK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Binding constant for CAMKK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "8573",
"properties": {
"id": "bosutinib targets CASK",
"source_label": "bosutinib",
"target_label": "CASK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.08",
"act_comment": "Binding constant for CASK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "11200",
"properties": {
"id": "bosutinib targets CHEK2",
"source_label": "bosutinib",
"target_label": "CHEK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Binding constant for CHEK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "1195",
"properties": {
"id": "bosutinib targets CLK1",
"source_label": "bosutinib",
"target_label": "CLK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Binding constant for CLK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "1198",
"properties": {
"id": "bosutinib targets CLK3",
"source_label": "bosutinib",
"target_label": "CLK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Binding constant for CLK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "1436",
"properties": {
"id": "bosutinib targets CSF1R",
"source_label": "bosutinib",
"target_label": "CSF1R",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Binding constant for CSF1R kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "1445",
"properties": {
"id": "bosutinib targets CSK",
"source_label": "bosutinib",
"target_label": "CSK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.49",
"act_comment": "Binding constant for CSK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "1452",
"properties": {
"id": "bosutinib targets CSNK1A1",
"source_label": "bosutinib",
"target_label": "CSNK1A1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Binding constant for CSNK1A1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "1453",
"properties": {
"id": "bosutinib targets CSNK1D",
"source_label": "bosutinib",
"target_label": "CSNK1D",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding constant for CSNK1D kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "1454",
"properties": {
"id": "bosutinib targets CSNK1E",
"source_label": "bosutinib",
"target_label": "CSNK1E",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Binding constant for CSNK1E kinase domain",
"act_source": "CHEMBL"
}
},
{
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}
},
{
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}
},
{
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
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}
},
{
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}
},
{
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}
},
{
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
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},
{
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}
},
{
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
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}
},
{
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}
},
{
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}
},
{
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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"act_source": "CHEMBL"
}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "11184",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "5871",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "8491",
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"id": "bosutinib targets MAP4K3",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "9448",
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"id": "bosutinib targets MAP4K4",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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"properties": {
"id": "bosutinib targets MAP4K5",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "22983",
"properties": {
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"act_value": "6.46",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "10461",
"properties": {
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "50488",
"properties": {
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"act_value": "8.49",
"act_comment": "Binding constant for MINK kinase domain",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "4638",
"properties": {
"id": "bosutinib targets MYLK",
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"act_value": "6.31",
"act_comment": "Binding constant for MYLK kinase domain",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "5159",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "10769",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "5747",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "2185",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
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}
},
{
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},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
"target": "494551",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:5328940",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:6918486",
"relation": "IDG (Drug Target)",
"target": "5478",
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}
},
{
"source": "CID:11658860",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11658860",
"relation": "IDG (Drug Target)",
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"properties": {
"id": "lorcaserin targets HTR2B",
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"act_source": "DRUG LABEL"
}
},
{
"source": "CID:11658860",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "lorcaserin targets HTR2C",
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"act_value": "7.886",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:2993",
"relation": "IDG (Drug Target)",
"target": "1259",
"properties": {
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"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:2993",
"relation": "IDG (Drug Target)",
"target": "3780",
"properties": {
"id": "dequalinium targets KCNN1",
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"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:16136245",
"relation": "IDG (Drug Target)",
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"properties": {
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}
},
{
"source": "CID:125017",
"relation": "IDG (Drug Target)",
"target": "6530",
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"id": "desvenlafaxine targets SLC6A2",
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"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:125017",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "desvenlafaxine targets SLC6A4",
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"act_type": "Ki",
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"act_value": "7.325",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:71353",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "dapoxetine targets SLC6A4",
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"act_relation": "=",
"act_value": "8.95",
"act_comment": "Inhibition of the reuptake of [3H]5-HT",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9865528",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "mirabegron targets ADRB3",
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"act_type": "EC50",
"act_relation": "=",
"act_value": "7.65",
"act_comment": "cAMP accumulation in CHO cells expressing human beta-3 adrenergic receptor",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5311507",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "clopenthixol targets HTR6",
"source_label": "clopenthixol",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1.5 hrs by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:135449332",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "eltrombopag targets KCNH2",
"source_label": "eltrombopag",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "Inhibition of human ERG channel tail current",
"act_source": "CHEMBL"
}
},
{
"source": "CID:135449332",
"relation": "IDG (Drug Target)",
"target": "4352",
"properties": {
"id": "eltrombopag targets MPL",
"source_label": "eltrombopag",
"target_label": "MPL",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9917021",
"relation": "IDG (Drug Target)",
"target": "6869",
"properties": {
"id": "casopitant targets TACR1",
"source_label": "casopitant",
"target_label": "TACR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.9",
"act_comment": "Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65015",
"relation": "IDG (Drug Target)",
"target": "57007",
"properties": {
"id": "plerixafor targets ACKR3",
"source_label": "plerixafor",
"target_label": "ACKR3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:65015",
"relation": "IDG (Drug Target)",
"target": "729230",
"properties": {
"id": "plerixafor targets CCR2",
"source_label": "plerixafor",
"target_label": "CCR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.4",
"act_comment": "Displacement of [125I]SDF1alpha from CCR2/CXCR4 expressed in CHOK1 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:65015",
"relation": "IDG (Drug Target)",
"target": "1233",
"properties": {
"id": "plerixafor targets CCR4",
"source_label": "plerixafor",
"target_label": "CCR4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:65015",
"relation": "IDG (Drug Target)",
"target": "7852",
"properties": {
"id": "plerixafor targets CXCR4",
"source_label": "plerixafor",
"target_label": "CXCR4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Displacement of [125I]12G5 antibody from human wild type CXCR4 expressed in COS7 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33036",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "dexchlorpheniramine targets CHRM1",
"source_label": "dexchlorpheniramine",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.478",
"act_comment": "DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:33036",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "dexchlorpheniramine targets CHRM3",
"source_label": "dexchlorpheniramine",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.262",
"act_comment": "DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:33036",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "dexchlorpheniramine targets CHRM4",
"source_label": "dexchlorpheniramine",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.559",
"act_comment": "DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:33036",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "dexchlorpheniramine targets CHRM5",
"source_label": "dexchlorpheniramine",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.126",
"act_comment": "DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:33036",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "dexchlorpheniramine targets HRH1",
"source_label": "dexchlorpheniramine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.14",
"act_comment": "DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:33036",
"relation": "IDG (Drug Target)",
"target": "10280",
"properties": {
"id": "dexchlorpheniramine targets SIGMAR1",
"source_label": "dexchlorpheniramine",
"target_label": "SIGMAR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.157",
"act_comment": "DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:33036",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "dexchlorpheniramine targets SLC6A3",
"source_label": "dexchlorpheniramine",
"target_label": "SLC6A3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.131",
"act_comment": "DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:33036",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "dexchlorpheniramine targets SLC6A4",
"source_label": "dexchlorpheniramine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.886",
"act_comment": "DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:114948",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "dihydroergocryptine targets HTR2B",
"source_label": "dihydroergocryptine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.48",
"act_comment": "Biased for β-arrestin signalling.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:16220008",
"relation": "IDG (Drug Target)",
"target": "799",
"properties": {
"id": "calcitonin human targets CALCR",
"source_label": "calcitonin human",
"target_label": "CALCR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.81",
"act_comment": "IC50 values for peptides in competition for 125I-labeled salmon CT binding to COS-7 cells cotransfected with 100 ng of hCTR and 100 ng of RAMP.",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:32798",
"relation": "IDG (Drug Target)",
"target": "1577",
"properties": {
"id": "clobetasol propionate targets CYP3A5",
"source_label": "clobetasol propionate",
"target_label": "CYP3A5",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.68",
"act_comment": "Inhibition of CYP3A5 in doxycycline-induced CYP3A5 overexpressing wild type human AsPC1 cells assessed as decrease in 1-hydroxymidazolam formation using midazolam as substrate pretreated with doxycycline for 24 hrs followed by incubation with compound for 24 hrs by LC-MS/MS analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:32798",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "clobetasol propionate targets NR3C1",
"source_label": "clobetasol propionate",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.179",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:6662",
"relation": "IDG (Drug Target)",
"target": "1909",
"properties": {
"id": "sulfisoxazole acetyl targets EDNRA",
"source_label": "sulfisoxazole acetyl",
"target_label": "EDNRA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Inhibitory concentration against Endothelin A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:27020",
"relation": "IDG (Drug Target)",
"target": "3276",
"properties": {
"id": "eosin targets PRMT1",
"source_label": "eosin",
"target_label": "PRMT1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:135413538",
"relation": "IDG (Drug Target)",
"target": "6869",
"properties": {
"id": "fosaprepitant targets TACR1",
"source_label": "fosaprepitant",
"target_label": "TACR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.92",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11556711",
"relation": "IDG (Drug Target)",
"target": "9446",
"properties": {
"id": "carfilzomib targets GSTO1",
"source_label": "carfilzomib",
"target_label": "GSTO1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "Inhibition of GSTO1-1 (unknown origin) pre-incubated for 1 hr before GSH addition by CDNB-GSH conjugation assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11556711",
"relation": "IDG (Drug Target)",
"target": "5699",
"properties": {
"id": "carfilzomib targets PSMB10",
"source_label": "carfilzomib",
"target_label": "PSMB10",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Inhibition of 20S proteasome beta 2i (unknown origin) after 1 hr by fluorescence based assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11556711",
"relation": "IDG (Drug Target)",
"target": "5690",
"properties": {
"id": "carfilzomib targets PSMB2",
"source_label": "carfilzomib",
"target_label": "PSMB2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.69",
"act_comment": "Inhibition of 20S proteasome beta2 subunit in human Jurkat cell lysate using Suc-RLR-AMC as substrate pretreated for 30 mins followed by substrate addition and measured after 60 mins by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11556711",
"relation": "IDG (Drug Target)",
"target": "5693",
"properties": {
"id": "carfilzomib targets PSMB5",
"source_label": "carfilzomib",
"target_label": "PSMB5",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.222",
"act_comment": "fluorogenic peptide substrate hydrolysis",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11556711",
"relation": "IDG (Drug Target)",
"target": "5696",
"properties": {
"id": "carfilzomib targets PSMB8",
"source_label": "carfilzomib",
"target_label": "PSMB8",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Inhibition of chymotrypsin-like activity of LMP7 immunoproteasome by proteasome active site ELISA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11434515",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "aclidinium bromide targets CHRM1",
"source_label": "aclidinium bromide",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.1",
"act_comment": "Binding affinity to muscarinic M1 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11434515",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "aclidinium bromide targets CHRM2",
"source_label": "aclidinium bromide",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.1",
"act_comment": "Binding affinity to muscarinic M2 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11434515",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "aclidinium bromide targets CHRM3",
"source_label": "aclidinium bromide",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.15",
"act_comment": "Binding affinity to muscarinic M3 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11434515",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "aclidinium bromide targets CHRM4",
"source_label": "aclidinium bromide",
"target_label": "CHRM4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "Displacement of [3H]NMS from human muscarinic M4 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11434515",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "aclidinium bromide targets CHRM5",
"source_label": "aclidinium bromide",
"target_label": "CHRM5",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.8",
"act_comment": "Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71414",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "diflorasone diacetate targets NR3C1",
"source_label": "diflorasone diacetate",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.536",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:52919",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "haloperidol decanoate targets DRD2",
"source_label": "haloperidol decanoate",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.34",
"act_comment": "Displacement of [3H]spiperone from human D2short receptor stably expressed in CHO cell membranes by competitive binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:52919",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "haloperidol decanoate targets DRD3",
"source_label": "haloperidol decanoate",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.46",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:52919",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "haloperidol decanoate targets DRD4",
"source_label": "haloperidol decanoate",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.24",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9690109",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "armodafinil targets DRD2",
"source_label": "armodafinil",
"target_label": "DRD2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.921",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:64929",
"relation": "IDG (Drug Target)",
"target": "2169",
"properties": {
"id": "choline fenofibrate targets FABP2",
"source_label": "choline fenofibrate",
"target_label": "FABP2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Displacement of 1-anilinonaphthalene-8-sulphonic acid from I-FABP",
"act_source": "CHEMBL"
}
},
{
"source": "CID:443943",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "halcinonide targets NR3C1",
"source_label": "halcinonide",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.135",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:838",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "racepinefrine targets ADRA1D",
"source_label": "racepinefrine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:16132393",
"relation": "IDG (Drug Target)",
"target": "5745",
"properties": {
"id": "teriparatide targets PTH1R",
"source_label": "teriparatide",
"target_label": "PTH1R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:16132393",
"relation": "IDG (Drug Target)",
"target": "5746",
"properties": {
"id": "teriparatide targets PTH2R",
"source_label": "teriparatide",
"target_label": "PTH2R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:16133751",
"relation": "IDG (Drug Target)",
"target": "4158",
"properties": {
"id": "tetracosactide targets MC2R",
"source_label": "tetracosactide",
"target_label": "MC2R",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.268",
"act_comment": "125I-ACTH binding in OS3 cells expressing hMC2R wild type",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:16133751",
"relation": "IDG (Drug Target)",
"target": "4160",
"properties": {
"id": "tetracosactide targets MC4R",
"source_label": "tetracosactide",
"target_label": "MC4R",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.19",
"act_comment": "Agonist activity at wild type human melanocortin-4 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9854489",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "fluticasone furoate targets NR3C1",
"source_label": "fluticasone furoate",
"target_label": "NR3C1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.12",
"act_comment": "Transrepression activity at glucocorticoid receptor in human H292 cells assessed as inhibition of TNF-stimulated IL-6 cytokine synthesis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9854489",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "fluticasone furoate targets NR3C2",
"source_label": "fluticasone furoate",
"target_label": "NR3C2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.83",
"act_comment": "Displacement of [3H]-aldosterone from N terminal maltose binding protein tagged human mineralocorticoid receptor LBD (726 to 984 residues) expressed in baculovirus infected high five cells after 8 hrs by scintillation proximity assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9854489",
"relation": "IDG (Drug Target)",
"target": "5241",
"properties": {
"id": "fluticasone furoate targets PGR",
"source_label": "fluticasone furoate",
"target_label": "PGR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.68",
"act_comment": "Displacement of fluormone labelled PL Red from human recombinant progesterone receptor after 1 to 6 hrs ligand by fluorescence polarization assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:55191",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "gepirone targets DRD2",
"source_label": "gepirone",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.24",
"act_comment": "Binding affinity to D2 receptor by radioligand binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:55191",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "gepirone targets HTR1A",
"source_label": "gepirone",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Displacement of [3H]8-OH-DPAT from human 5HT1A receptor in HEK293 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:213043",
"relation": "IDG (Drug Target)",
"target": "1719",
"properties": {
"id": "iclaprim targets DHFR",
"source_label": "iclaprim",
"target_label": "DHFR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spectrophotometry",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5281612",
"relation": "IDG (Drug Target)",
"target": "1545",
"properties": {
"id": "diosmetin targets CYP1B1",
"source_label": "diosmetin",
"target_label": "CYP1B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.54",
"act_comment": "Inhibition of human CYP1B1 by EROD assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5281612",
"relation": "IDG (Drug Target)",
"target": "51447",
"properties": {
"id": "diosmetin targets IP6K2",
"source_label": "diosmetin",
"target_label": "IP6K2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Inhibition of human IP6K2 using insP6 as substrate preincubated for 15 mins followed by substrate and measured after 30 mins by TR-FRET assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5361918",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "methylnaltrexone targets OPRD1",
"source_label": "methylnaltrexone",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cells after 3 hrs by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5361918",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "methylnaltrexone targets OPRK1",
"source_label": "methylnaltrexone",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.65",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5361918",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "methylnaltrexone targets OPRM1",
"source_label": "methylnaltrexone",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.55",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5280934",
"relation": "IDG (Drug Target)",
"target": "2170",
"properties": {
"id": "linolenic acid targets FABP3",
"source_label": "linolenic acid",
"target_label": "FABP3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.56",
"act_comment": "Binding affinity to human FABP3 expressed in Escherichia coli BL21 (DE3) in DMPC liposomes by surface plasmon resonance analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5280934",
"relation": "IDG (Drug Target)",
"target": "5465",
"properties": {
"id": "linolenic acid targets PPARA",
"source_label": "linolenic acid",
"target_label": "PPARA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "Binding affinity to PPAR-alpha (unknown origin) by fluorescence-based assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16158208",
"relation": "IDG (Drug Target)",
"target": "2984",
"properties": {
"id": "linaclotide targets GUCY2C",
"source_label": "linaclotide",
"target_label": "GUCY2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.907",
"act_comment": "competitive radioligand binding assay with [125I]-STa",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9833444",
"relation": "IDG (Drug Target)",
"target": "886",
"properties": {
"id": "sincalide targets CCKAR",
"source_label": "sincalide",
"target_label": "CCKAR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.55",
"act_comment": "Displacement of radiolabeled CCK-8s from human CCK1 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9833444",
"relation": "IDG (Drug Target)",
"target": "887",
"properties": {
"id": "sincalide targets CCKBR",
"source_label": "sincalide",
"target_label": "CCKBR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.55",
"act_comment": "Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:15951529",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "enzalutamide targets AR",
"source_label": "enzalutamide",
"target_label": "AR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.31",
"act_comment": "Displacement of [3H]R1881 from AR in human MDA-MB-453 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:108150",
"relation": "IDG (Drug Target)",
"target": "6714",
"properties": {
"id": "trabectedin targets SRC",
"source_label": "trabectedin",
"target_label": "SRC",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Inhibition of Src",
"act_source": "CHEMBL"
}
},
{
"source": "CID:54684141",
"relation": "IDG (Drug Target)",
"target": "1719",
"properties": {
"id": "teriflunomide targets DHFR",
"source_label": "teriflunomide",
"target_label": "DHFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "Inhibition of recombinant human N-terminal truncated GST-tagged DHFR (31 to 395 residues) expressed in Escherichia coli BL21(DE3) pyrD using DHO as substrate preincubated for 5 mins followed by substrate addition measured for 5 mins by DCIP oxidation based CoQ10 enzyme coupled assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:54684141",
"relation": "IDG (Drug Target)",
"target": "1723",
"properties": {
"id": "teriflunomide targets DHODH",
"source_label": "teriflunomide",
"target_label": "DHODH",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "Inhibition of human recombinant DHODH",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3893",
"relation": "IDG (Drug Target)",
"target": "2864",
"properties": {
"id": "dodecanoic acid targets FFAR1",
"source_label": "dodecanoic acid",
"target_label": "FFAR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:240767",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "fluorometholone acetate targets NR3C1",
"source_label": "fluorometholone acetate",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.347",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "regorafenib targets ABL1",
"source_label": "regorafenib",
"target_label": "ABL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "613",
"properties": {
"id": "regorafenib targets BCR",
"source_label": "regorafenib",
"target_label": "BCR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "673",
"properties": {
"id": "regorafenib targets BRAF",
"source_label": "regorafenib",
"target_label": "BRAF",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.55",
"act_comment": "Inhibition of wild-type B-Raf",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "5128",
"properties": {
"id": "regorafenib targets CDK17",
"source_label": "regorafenib",
"target_label": "CDK17",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "780",
"properties": {
"id": "regorafenib targets DDR1",
"source_label": "regorafenib",
"target_label": "DDR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.45",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "4921",
"properties": {
"id": "regorafenib targets DDR2",
"source_label": "regorafenib",
"target_label": "DDR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "2041",
"properties": {
"id": "regorafenib targets EPHA1",
"source_label": "regorafenib",
"target_label": "EPHA1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.15",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "1969",
"properties": {
"id": "regorafenib targets EPHA2",
"source_label": "regorafenib",
"target_label": "EPHA2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.08",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "2053",
"properties": {
"id": "regorafenib targets EPHX2",
"source_label": "regorafenib",
"target_label": "EPHX2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "2260",
"properties": {
"id": "regorafenib targets FGFR1",
"source_label": "regorafenib",
"target_label": "FGFR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.82",
"act_comment": "Inhibition of FGFR1 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "2321",
"properties": {
"id": "regorafenib targets FLT1",
"source_label": "regorafenib",
"target_label": "FLT1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.82",
"act_comment": "Inhibition of VEGFR1 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "regorafenib targets FLT3",
"source_label": "regorafenib",
"target_label": "FLT3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.09",
"act_comment": "Inhibition of wild type recombinant GST-tagged FLT3 (Y567 to S993 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells using Her2 peptide as substrate measured after 4 hrs in presence of ATP by Kinase-Glo Plus reagent-based luminescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "regorafenib targets KDR",
"source_label": "regorafenib",
"target_label": "KDR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "regorafenib targets KIT",
"source_label": "regorafenib",
"target_label": "KIT",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.21",
"act_comment": "Inhibition of wild type KIT (unknown origin) using biotinylated poly-Glu-Tyr as substrate preincubated for 30 mins followed by substrate addition in presence of ATP by TR-FRET assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "3984",
"properties": {
"id": "regorafenib targets LIMK1",
"source_label": "regorafenib",
"target_label": "LIMK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "4214",
"properties": {
"id": "regorafenib targets MAP3K1",
"source_label": "regorafenib",
"target_label": "MAP3K1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "1432",
"properties": {
"id": "regorafenib targets MAPK14",
"source_label": "regorafenib",
"target_label": "MAPK14",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "9261",
"properties": {
"id": "regorafenib targets MAPKAPK2",
"source_label": "regorafenib",
"target_label": "MAPKAPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "regorafenib targets PDGFRB",
"source_label": "regorafenib",
"target_label": "PDGFRB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.82",
"act_comment": "Inhibition of PDGFR beta (561 to 1106 residues) (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "5894",
"properties": {
"id": "regorafenib targets RAF1",
"source_label": "regorafenib",
"target_label": "RAF1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.82",
"act_comment": "Inhibition of RAF1 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "regorafenib targets RET",
"source_label": "regorafenib",
"target_label": "RET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "regorafenib targets RIPK2",
"source_label": "regorafenib",
"target_label": "RIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "11035",
"properties": {
"id": "regorafenib targets RIPK3",
"source_label": "regorafenib",
"target_label": "RIPK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.43",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "7010",
"properties": {
"id": "regorafenib targets TEK",
"source_label": "regorafenib",
"target_label": "TEK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.82",
"act_comment": "Inhibition of GST-tagged TIE2 (unknown origin) using biotin-Ahx-EPKDDAYPLYSDFG peptide as substrate by HTRF method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11167602",
"relation": "IDG (Drug Target)",
"target": "51776",
"properties": {
"id": "regorafenib targets MAP3K20",
"source_label": "regorafenib",
"target_label": "MAP3K20",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.56",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:243",
"relation": "IDG (Drug Target)",
"target": "93100",
"properties": {
"id": "benzoic acid targets NAPRT",
"source_label": "benzoic acid",
"target_label": "NAPRT",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.72",
"act_comment": "Inhibition of NAPRT (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:107782",
"relation": "IDG (Drug Target)",
"target": "2908",
"properties": {
"id": "betamethasone phosphate targets NR3C1",
"source_label": "betamethasone phosphate",
"target_label": "NR3C1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.428",
"act_comment": "DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:28688",
"relation": "IDG (Drug Target)",
"target": "11188",
"properties": {
"id": "metizoline targets NISCH",
"source_label": "metizoline",
"target_label": "NISCH",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.2",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6445230",
"relation": "IDG (Drug Target)",
"target": "3061",
"properties": {
"id": "nalfurafine targets HCRTR1",
"source_label": "nalfurafine",
"target_label": "HCRTR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15 mins followed by orexin A addition by Fura-2-AM dye based fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6445230",
"relation": "IDG (Drug Target)",
"target": "5594",
"properties": {
"id": "nalfurafine targets MAPK1",
"source_label": "nalfurafine",
"target_label": "MAPK1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.26",
"act_comment": "Inhibition of ERK2 phosphorylation (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6445230",
"relation": "IDG (Drug Target)",
"target": "5595",
"properties": {
"id": "nalfurafine targets MAPK3",
"source_label": "nalfurafine",
"target_label": "MAPK3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.26",
"act_comment": "Inhibition of ERK1 phosphorylation (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6445230",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "nalfurafine targets OPRD1",
"source_label": "nalfurafine",
"target_label": "OPRD1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.13",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6445230",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "nalfurafine targets OPRK1",
"source_label": "nalfurafine",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.64",
"act_comment": "Binding affinity to kappa opioid receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6445230",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "nalfurafine targets OPRM1",
"source_label": "nalfurafine",
"target_label": "OPRM1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.14",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918837",
"relation": "IDG (Drug Target)",
"target": "23476",
"properties": {
"id": "panobinostat targets BRD4",
"source_label": "panobinostat",
"target_label": "BRD4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "Inhibition of BRD4 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918837",
"relation": "IDG (Drug Target)",
"target": "3065",
"properties": {
"id": "panobinostat targets HDAC1",
"source_label": "panobinostat",
"target_label": "HDAC1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "Inhibition of human HDAC1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918837",
"relation": "IDG (Drug Target)",
"target": "83933",
"properties": {
"id": "panobinostat targets HDAC10",
"source_label": "panobinostat",
"target_label": "HDAC10",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.51",
"act_comment": "Competitive inhibition of HDAC10 using KI-104 as substrate by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918837",
"relation": "IDG (Drug Target)",
"target": "79885",
"properties": {
"id": "panobinostat targets HDAC11",
"source_label": "panobinostat",
"target_label": "HDAC11",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.46",
"act_comment": "Competitive inhibition of HDAC11 using KI-104 as substrate by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918837",
"relation": "IDG (Drug Target)",
"target": "3066",
"properties": {
"id": "panobinostat targets HDAC2",
"source_label": "panobinostat",
"target_label": "HDAC2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.19",
"act_comment": "Inhibition of human HDAC2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918837",
"relation": "IDG (Drug Target)",
"target": "8841",
"properties": {
"id": "panobinostat targets HDAC3",
"source_label": "panobinostat",
"target_label": "HDAC3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.96",
"act_comment": "Inhibition of human HDAC3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918837",
"relation": "IDG (Drug Target)",
"target": "9759",
"properties": {
"id": "panobinostat targets HDAC4",
"source_label": "panobinostat",
"target_label": "HDAC4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.22",
"act_comment": "Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918837",
"relation": "IDG (Drug Target)",
"target": "10014",
"properties": {
"id": "panobinostat targets HDAC5",
"source_label": "panobinostat",
"target_label": "HDAC5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.15",
"act_comment": "Competitive inhibition of HDAC5 using KI-104 as substrate by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918837",
"relation": "IDG (Drug Target)",
"target": "10013",
"properties": {
"id": "panobinostat targets HDAC6",
"source_label": "panobinostat",
"target_label": "HDAC6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.15",
"act_comment": "Competitive inhibition of HDAC6 using KI-104 as substrate by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918837",
"relation": "IDG (Drug Target)",
"target": "51564",
"properties": {
"id": "panobinostat targets HDAC7",
"source_label": "panobinostat",
"target_label": "HDAC7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.64",
"act_comment": "Competitive inhibition of HDAC7 using KI-104 as substrate by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918837",
"relation": "IDG (Drug Target)",
"target": "55869",
"properties": {
"id": "panobinostat targets HDAC8",
"source_label": "panobinostat",
"target_label": "HDAC8",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.66",
"act_comment": "Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918837",
"relation": "IDG (Drug Target)",
"target": "9734",
"properties": {
"id": "panobinostat targets HDAC9",
"source_label": "panobinostat",
"target_label": "HDAC9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.92",
"act_comment": "Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9395",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "paraoxon targets ACHE",
"source_label": "paraoxon",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Inhibition of human AChE using p-nitrophenyl acetate as substrate measured for 30 secs by spectrophotometric analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9395",
"relation": "IDG (Drug Target)",
"target": "590",
"properties": {
"id": "paraoxon targets BCHE",
"source_label": "paraoxon",
"target_label": "BCHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.15",
"act_comment": "Inhibition of human BChE using butyrylthiocholine as substrate measured for 30 secs by Ellman's method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9395",
"relation": "IDG (Drug Target)",
"target": "759",
"properties": {
"id": "paraoxon targets CA1",
"source_label": "paraoxon",
"target_label": "CA1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "Inhibition of esterase activity of human carbonic anhydrase 1 by CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9395",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "paraoxon targets CA2",
"source_label": "paraoxon",
"target_label": "CA2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.23",
"act_comment": "Inhibition of esterase activity of human carbonic anhydrase 2 by CO2 hydration method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:1684",
"relation": "IDG (Drug Target)",
"target": "8856",
"properties": {
"id": "pleconaril targets NR1I2",
"source_label": "pleconaril",
"target_label": "NR1I2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Activation of human PXR expressed in african green monkey CV1 cells transfected with pSG5-hPXRDATG and (ER6)3-tk-CAT reporter",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6324659",
"relation": "IDG (Drug Target)",
"target": "5972",
"properties": {
"id": "remikiren targets REN",
"source_label": "remikiren",
"target_label": "REN",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.155",
"act_comment": "purified human renin",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:180559",
"relation": "IDG (Drug Target)",
"target": "140",
"properties": {
"id": "esatenolol targets ADORA3",
"source_label": "esatenolol",
"target_label": "ADORA3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.75",
"act_comment": "Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:180559",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "esatenolol targets ADRB1",
"source_label": "esatenolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "Binding affinity to human adrenergic beta1 receptor by radioligand displacement assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9926791",
"relation": "IDG (Drug Target)",
"target": "9212",
"properties": {
"id": "tofacitinib targets AURKB",
"source_label": "tofacitinib",
"target_label": "AURKB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9926791",
"relation": "IDG (Drug Target)",
"target": "85443",
"properties": {
"id": "tofacitinib targets DCLK3",
"source_label": "tofacitinib",
"target_label": "DCLK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.35",
"act_comment": "Binding affinity to DCamkL3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9926791",
"relation": "IDG (Drug Target)",
"target": "3716",
"properties": {
"id": "tofacitinib targets JAK1",
"source_label": "tofacitinib",
"target_label": "JAK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.17",
"act_comment": "Inhibition of human recombinant GST-tagged JAK1 using 5-FAM-KKSRGDYMTMQIG as substrate by peptide mobility shift assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9926791",
"relation": "IDG (Drug Target)",
"target": "3717",
"properties": {
"id": "tofacitinib targets JAK2",
"source_label": "tofacitinib",
"target_label": "JAK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.24",
"act_comment": "Binding constant for JAK2(JH1domain-catalytic) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9926791",
"relation": "IDG (Drug Target)",
"target": "3718",
"properties": {
"id": "tofacitinib targets JAK3",
"source_label": "tofacitinib",
"target_label": "JAK3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.481",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:9926791",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "tofacitinib targets LCK",
"source_label": "tofacitinib",
"target_label": "LCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.34",
"act_comment": "Binding constant for LCK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9926791",
"relation": "IDG (Drug Target)",
"target": "120892",
"properties": {
"id": "tofacitinib targets LRRK2",
"source_label": "tofacitinib",
"target_label": "LRRK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "Binding constant for LRRK2(G2019S) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9926791",
"relation": "IDG (Drug Target)",
"target": "5604",
"properties": {
"id": "tofacitinib targets MAP2K1",
"source_label": "tofacitinib",
"target_label": "MAP2K1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9926791",
"relation": "IDG (Drug Target)",
"target": "81788",
"properties": {
"id": "tofacitinib targets NUAK2",
"source_label": "tofacitinib",
"target_label": "NUAK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding constant for SNARK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9926791",
"relation": "IDG (Drug Target)",
"target": "5585",
"properties": {
"id": "tofacitinib targets PKN1",
"source_label": "tofacitinib",
"target_label": "PKN1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Binding constant for PKN1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9926791",
"relation": "IDG (Drug Target)",
"target": "6093",
"properties": {
"id": "tofacitinib targets ROCK1",
"source_label": "tofacitinib",
"target_label": "ROCK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Binding constant for ROCK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9926791",
"relation": "IDG (Drug Target)",
"target": "9475",
"properties": {
"id": "tofacitinib targets ROCK2",
"source_label": "tofacitinib",
"target_label": "ROCK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Binding constant for ROCK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9926791",
"relation": "IDG (Drug Target)",
"target": "6196",
"properties": {
"id": "tofacitinib targets RPS6KA2",
"source_label": "tofacitinib",
"target_label": "RPS6KA2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Binding constant for RSK3(Kin.Dom.2-C-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9926791",
"relation": "IDG (Drug Target)",
"target": "27330",
"properties": {
"id": "tofacitinib targets RPS6KA6",
"source_label": "tofacitinib",
"target_label": "RPS6KA6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.27",
"act_comment": "Binding constant for RSK4(Kin.Dom.2-C-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9926791",
"relation": "IDG (Drug Target)",
"target": "8711",
"properties": {
"id": "tofacitinib targets TNK1",
"source_label": "tofacitinib",
"target_label": "TNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Binding constant for TNK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9926791",
"relation": "IDG (Drug Target)",
"target": "7297",
"properties": {
"id": "tofacitinib targets TYK2",
"source_label": "tofacitinib",
"target_label": "TYK2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.36",
"act_comment": "Inhibition of human recombinant GST-tagged TYK2 using 5-FAM-KKSRGDYMTMQIG as substrate by peptide mobility shift assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "27",
"properties": {
"id": "cabozantinib targets ABL2",
"source_label": "cabozantinib",
"target_label": "ABL2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "558",
"properties": {
"id": "cabozantinib targets AXL",
"source_label": "cabozantinib",
"target_label": "AXL",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.47",
"act_comment": "Inhibition of AXL (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 1 hr by ELISA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "613",
"properties": {
"id": "cabozantinib targets BCR",
"source_label": "cabozantinib",
"target_label": "BCR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "780",
"properties": {
"id": "cabozantinib targets DDR1",
"source_label": "cabozantinib",
"target_label": "DDR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "4921",
"properties": {
"id": "cabozantinib targets DDR2",
"source_label": "cabozantinib",
"target_label": "DDR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "cabozantinib targets EGFR",
"source_label": "cabozantinib",
"target_label": "EGFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.65",
"act_comment": "Inhibition of EGFR (unknown origin) by HTRF method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "1969",
"properties": {
"id": "cabozantinib targets EPHA2",
"source_label": "cabozantinib",
"target_label": "EPHA2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "2260",
"properties": {
"id": "cabozantinib targets FGFR1",
"source_label": "cabozantinib",
"target_label": "FGFR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.95",
"act_comment": "Inhibition of FLT2 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "2321",
"properties": {
"id": "cabozantinib targets FLT1",
"source_label": "cabozantinib",
"target_label": "FLT1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Inhibition of FLT1 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "cabozantinib targets FLT3",
"source_label": "cabozantinib",
"target_label": "FLT3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.947",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "2324",
"properties": {
"id": "cabozantinib targets FLT4",
"source_label": "cabozantinib",
"target_label": "FLT4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "Inhibition of VEGFR3 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "2444",
"properties": {
"id": "cabozantinib targets FRK",
"source_label": "cabozantinib",
"target_label": "FRK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "cabozantinib targets KDR",
"source_label": "cabozantinib",
"target_label": "KDR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.456",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "cabozantinib targets KIT",
"source_label": "cabozantinib",
"target_label": "KIT",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.337",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "4233",
"properties": {
"id": "cabozantinib targets MET",
"source_label": "cabozantinib",
"target_label": "MET",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.886",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "4486",
"properties": {
"id": "cabozantinib targets MST1R",
"source_label": "cabozantinib",
"target_label": "MST1R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.907",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "cabozantinib targets RET",
"source_label": "cabozantinib",
"target_label": "RET",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.284",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "cabozantinib targets RIPK2",
"source_label": "cabozantinib",
"target_label": "RIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "6714",
"properties": {
"id": "cabozantinib targets SRC",
"source_label": "cabozantinib",
"target_label": "SRC",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.75",
"act_comment": "Inhibition of Src (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25102847",
"relation": "IDG (Drug Target)",
"target": "7010",
"properties": {
"id": "cabozantinib targets TEK",
"source_label": "cabozantinib",
"target_label": "TEK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.845",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "ponatinib targets ABL1",
"source_label": "ponatinib",
"target_label": "ABL1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.432",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "27",
"properties": {
"id": "ponatinib targets ABL2",
"source_label": "ponatinib",
"target_label": "ABL2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "613",
"properties": {
"id": "ponatinib targets BCR",
"source_label": "ponatinib",
"target_label": "BCR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "5128",
"properties": {
"id": "ponatinib targets CDK17",
"source_label": "ponatinib",
"target_label": "CDK17",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "23097",
"properties": {
"id": "ponatinib targets CDK19",
"source_label": "ponatinib",
"target_label": "CDK19",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "CDK19/cyclin C.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "1024",
"properties": {
"id": "ponatinib targets CDK8",
"source_label": "ponatinib",
"target_label": "CDK8",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.17",
"act_comment": "CDK8/cyclin C.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "1445",
"properties": {
"id": "ponatinib targets CSK",
"source_label": "ponatinib",
"target_label": "CSK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.268",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "780",
"properties": {
"id": "ponatinib targets DDR1",
"source_label": "ponatinib",
"target_label": "DDR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.75",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "4921",
"properties": {
"id": "ponatinib targets DDR2",
"source_label": "ponatinib",
"target_label": "DDR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.06",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "1653",
"properties": {
"id": "ponatinib targets DDX1",
"source_label": "ponatinib",
"target_label": "DDX1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.07",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "1969",
"properties": {
"id": "ponatinib targets EPHA2",
"source_label": "ponatinib",
"target_label": "EPHA2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.57",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "2044",
"properties": {
"id": "ponatinib targets EPHA5",
"source_label": "ponatinib",
"target_label": "EPHA5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.1",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "2049",
"properties": {
"id": "ponatinib targets EPHB3",
"source_label": "ponatinib",
"target_label": "EPHB3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "2260",
"properties": {
"id": "ponatinib targets FGFR1",
"source_label": "ponatinib",
"target_label": "FGFR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.658",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "2263",
"properties": {
"id": "ponatinib targets FGFR2",
"source_label": "ponatinib",
"target_label": "FGFR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.89",
"act_comment": "Inhibition of recombinant FGFR2 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "2261",
"properties": {
"id": "ponatinib targets FGFR3",
"source_label": "ponatinib",
"target_label": "FGFR3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.03",
"act_comment": "Inhibition of recombinant FGFR3 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "2264",
"properties": {
"id": "ponatinib targets FGFR4",
"source_label": "ponatinib",
"target_label": "FGFR4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.15",
"act_comment": "Inhibition of recombinant FGFR4 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "2268",
"properties": {
"id": "ponatinib targets FGR",
"source_label": "ponatinib",
"target_label": "FGR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "ponatinib targets FLT3",
"source_label": "ponatinib",
"target_label": "FLT3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.52",
"act_comment": "Inhibition of FLT3 in human MV4-11 cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "2444",
"properties": {
"id": "ponatinib targets FRK",
"source_label": "ponatinib",
"target_label": "FRK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.03",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "2534",
"properties": {
"id": "ponatinib targets FYN",
"source_label": "ponatinib",
"target_label": "FYN",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.44",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "3055",
"properties": {
"id": "ponatinib targets HCK",
"source_label": "ponatinib",
"target_label": "HCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.09",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "3654",
"properties": {
"id": "ponatinib targets IRAK1",
"source_label": "ponatinib",
"target_label": "IRAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "ponatinib targets KCNH2",
"source_label": "ponatinib",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Inhibition of human ERG incubated for 4 hrs by competitive fluorescence tracer binding based assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "ponatinib targets KDR",
"source_label": "ponatinib",
"target_label": "KDR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.824",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "ponatinib targets KIT",
"source_label": "ponatinib",
"target_label": "KIT",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.903",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "ponatinib targets LCK",
"source_label": "ponatinib",
"target_label": "LCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.62",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "4067",
"properties": {
"id": "ponatinib targets LYN",
"source_label": "ponatinib",
"target_label": "LYN",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.62",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "4214",
"properties": {
"id": "ponatinib targets MAP3K1",
"source_label": "ponatinib",
"target_label": "MAP3K1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.31",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "11184",
"properties": {
"id": "ponatinib targets MAP4K1",
"source_label": "ponatinib",
"target_label": "MAP4K1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "5871",
"properties": {
"id": "ponatinib targets MAP4K2",
"source_label": "ponatinib",
"target_label": "MAP4K2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.39",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "9448",
"properties": {
"id": "ponatinib targets MAP4K4",
"source_label": "ponatinib",
"target_label": "MAP4K4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "5600",
"properties": {
"id": "ponatinib targets MAPK11",
"source_label": "ponatinib",
"target_label": "MAPK11",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "1432",
"properties": {
"id": "ponatinib targets MAPK14",
"source_label": "ponatinib",
"target_label": "MAPK14",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.81",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "9261",
"properties": {
"id": "ponatinib targets MAPKAPK2",
"source_label": "ponatinib",
"target_label": "MAPKAPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "4638",
"properties": {
"id": "ponatinib targets MYLK",
"source_label": "ponatinib",
"target_label": "MYLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "5156",
"properties": {
"id": "ponatinib targets PDGFRA",
"source_label": "ponatinib",
"target_label": "PDGFRA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.959",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "ponatinib targets PDGFRB",
"source_label": "ponatinib",
"target_label": "PDGFRB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.92",
"act_comment": "Inhibition of recombinant PDGFRbeta (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "2185",
"properties": {
"id": "ponatinib targets PTK2B",
"source_label": "ponatinib",
"target_label": "PTK2B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.53",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "ponatinib targets RET",
"source_label": "ponatinib",
"target_label": "RET",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.59",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "8737",
"properties": {
"id": "ponatinib targets RIPK1",
"source_label": "ponatinib",
"target_label": "RIPK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Inhibition of recombinant RIPK1 in an in vitro ADP-Glo assay (Promega).",
"act_source": "IUPHAR"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "ponatinib targets RIPK2",
"source_label": "ponatinib",
"target_label": "RIPK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.17",
"act_comment": "Inhibition of human RIPK2 expressed in Sf9 cells after 1 hr by ADP-Glo assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "11035",
"properties": {
"id": "ponatinib targets RIPK3",
"source_label": "ponatinib",
"target_label": "RIPK3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "Inhibition of recombinant RIPK3 in an in vitro ADP-Glo assay (Promega).",
"act_source": "IUPHAR"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "6714",
"properties": {
"id": "ponatinib targets SRC",
"source_label": "ponatinib",
"target_label": "SRC",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "23043",
"properties": {
"id": "ponatinib targets TNIK",
"source_label": "ponatinib",
"target_label": "TNIK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "8711",
"properties": {
"id": "ponatinib targets TNK1",
"source_label": "ponatinib",
"target_label": "TNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.08",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "7525",
"properties": {
"id": "ponatinib targets YES1",
"source_label": "ponatinib",
"target_label": "YES1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24826799",
"relation": "IDG (Drug Target)",
"target": "51776",
"properties": {
"id": "ponatinib targets MAP3K20",
"source_label": "ponatinib",
"target_label": "MAP3K20",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.39",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16139605",
"relation": "IDG (Drug Target)",
"target": "9340",
"properties": {
"id": "teduglutide targets GLP2R",
"source_label": "teduglutide",
"target_label": "GLP2R",
"act_type": "EC50",
"act_relation": "=",
"act_value": "10.05",
"act_comment": "Agonist activity at human GLP2R expressed in HEK293 cells after 5 hrs by luciferase reporter gene assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9853053",
"relation": "IDG (Drug Target)",
"target": "4547",
"properties": {
"id": "lomitapide targets MTTP",
"source_label": "lomitapide",
"target_label": "MTTP",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.097",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:5283734",
"relation": "IDG (Drug Target)",
"target": "7421",
"properties": {
"id": "tacalcitol targets VDR",
"source_label": "tacalcitol",
"target_label": "VDR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.5",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:57946",
"relation": "IDG (Drug Target)",
"target": "1544",
"properties": {
"id": "tenidap targets CYP1A2",
"source_label": "tenidap",
"target_label": "CYP1A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:57946",
"relation": "IDG (Drug Target)",
"target": "1559",
"properties": {
"id": "tenidap targets CYP2C9",
"source_label": "tenidap",
"target_label": "CYP2C9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.155",
"act_comment": "DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:57946",
"relation": "IDG (Drug Target)",
"target": "3761",
"properties": {
"id": "tenidap targets KCNJ4",
"source_label": "tenidap",
"target_label": "KCNJ4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:57946",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "tenidap targets PTGS1",
"source_label": "tenidap",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.26",
"act_comment": "DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:57946",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "tenidap targets PTGS2",
"source_label": "tenidap",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.573",
"act_comment": "DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid)",
"act_source": "DRUG MATRIX"
}
},
{
"source": "CID:864",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "thioctic acid targets ACHE",
"source_label": "thioctic acid",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "Inhibition of human AchE",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5388906",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "bedaquiline targets KCNH2",
"source_label": "bedaquiline",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.43",
"act_comment": "Inhibition of human ERG",
"act_source": "CHEMBL"
}
},
{
"source": "CID:134780",
"relation": "IDG (Drug Target)",
"target": "51185",
"properties": {
"id": "pomalidomide targets CRBN",
"source_label": "pomalidomide",
"target_label": "CRBN",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.577",
"act_comment": "competitive titration of thalidomide with human DDB1-human CRBN (50 nM) and Cy5-thalidomide (20 nM)",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:3036505",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "ospemifene targets ESR1",
"source_label": "ospemifene",
"target_label": "ESR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.082",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:60657",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "levobetaxolol targets ADRB1",
"source_label": "levobetaxolol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:60657",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "levobetaxolol targets ADRB2",
"source_label": "levobetaxolol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.49",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:637568",
"relation": "IDG (Drug Target)",
"target": "338442",
"properties": {
"id": "dimethyl fumarate targets HCAR2",
"source_label": "dimethyl fumarate",
"target_label": "HCAR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24812758",
"relation": "IDG (Drug Target)",
"target": "6524",
"properties": {
"id": "canagliflozin targets SLC5A2",
"source_label": "canagliflozin",
"target_label": "SLC5A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.658",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:11520894",
"relation": "IDG (Drug Target)",
"target": "2475",
"properties": {
"id": "ridaforolimus targets MTOR",
"source_label": "ridaforolimus",
"target_label": "MTOR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.699",
"act_comment": "Measured as dose-dependent inhibition of phosphorylation of ribosomal protein S6, a signaling protein downstream of mTOR",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:10184665",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "vilanterol targets ADRB1",
"source_label": "vilanterol",
"target_label": "ADRB1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:10184665",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "vilanterol targets ADRB2",
"source_label": "vilanterol",
"target_label": "ADRB2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:10184665",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "vilanterol targets ADRB3",
"source_label": "vilanterol",
"target_label": "ADRB3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "27",
"properties": {
"id": "dabrafenib targets ABL2",
"source_label": "dabrafenib",
"target_label": "ABL2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "91",
"properties": {
"id": "dabrafenib targets ACVR1B",
"source_label": "dabrafenib",
"target_label": "ACVR1B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "369",
"properties": {
"id": "dabrafenib targets ARAF",
"source_label": "dabrafenib",
"target_label": "ARAF",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.59",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "673",
"properties": {
"id": "dabrafenib targets BRAF",
"source_label": "dabrafenib",
"target_label": "BRAF",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.155",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "983",
"properties": {
"id": "dabrafenib targets CDK1",
"source_label": "dabrafenib",
"target_label": "CDK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "5127",
"properties": {
"id": "dabrafenib targets CDK16",
"source_label": "dabrafenib",
"target_label": "CDK16",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "5128",
"properties": {
"id": "dabrafenib targets CDK17",
"source_label": "dabrafenib",
"target_label": "CDK17",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.44",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "1017",
"properties": {
"id": "dabrafenib targets CDK2",
"source_label": "dabrafenib",
"target_label": "CDK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "1019",
"properties": {
"id": "dabrafenib targets CDK4",
"source_label": "dabrafenib",
"target_label": "CDK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "1021",
"properties": {
"id": "dabrafenib targets CDK6",
"source_label": "dabrafenib",
"target_label": "CDK6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "1445",
"properties": {
"id": "dabrafenib targets CSK",
"source_label": "dabrafenib",
"target_label": "CSK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "27102",
"properties": {
"id": "dabrafenib targets EIF2AK1",
"source_label": "dabrafenib",
"target_label": "EIF2AK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "2041",
"properties": {
"id": "dabrafenib targets EPHA1",
"source_label": "dabrafenib",
"target_label": "EPHA1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "2051",
"properties": {
"id": "dabrafenib targets EPHB6",
"source_label": "dabrafenib",
"target_label": "EPHB6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "10595",
"properties": {
"id": "dabrafenib targets ERN2",
"source_label": "dabrafenib",
"target_label": "ERN2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.94",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "2444",
"properties": {
"id": "dabrafenib targets FRK",
"source_label": "dabrafenib",
"target_label": "FRK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "2534",
"properties": {
"id": "dabrafenib targets FYN",
"source_label": "dabrafenib",
"target_label": "FYN",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "dabrafenib targets LCK",
"source_label": "dabrafenib",
"target_label": "LCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "3984",
"properties": {
"id": "dabrafenib targets LIMK1",
"source_label": "dabrafenib",
"target_label": "LIMK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.48",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "3985",
"properties": {
"id": "dabrafenib targets LIMK2",
"source_label": "dabrafenib",
"target_label": "LIMK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.09",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "4296",
"properties": {
"id": "dabrafenib targets MAP3K11",
"source_label": "dabrafenib",
"target_label": "MAP3K11",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "4750",
"properties": {
"id": "dabrafenib targets NEK1",
"source_label": "dabrafenib",
"target_label": "NEK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.32",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "91754",
"properties": {
"id": "dabrafenib targets NEK9",
"source_label": "dabrafenib",
"target_label": "NEK9",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.28",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "10733",
"properties": {
"id": "dabrafenib targets PLK4",
"source_label": "dabrafenib",
"target_label": "PLK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "25865",
"properties": {
"id": "dabrafenib targets PRKD2",
"source_label": "dabrafenib",
"target_label": "PRKD2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.47",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "23683",
"properties": {
"id": "dabrafenib targets PRKD3",
"source_label": "dabrafenib",
"target_label": "PRKD3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "5894",
"properties": {
"id": "dabrafenib targets RAF1",
"source_label": "dabrafenib",
"target_label": "RAF1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "dabrafenib targets RIPK2",
"source_label": "dabrafenib",
"target_label": "RIPK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.11",
"act_comment": "Inhibition of human RIPK2 using MBP as substrate by [gamma33-ATP] based radiometric assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "11035",
"properties": {
"id": "dabrafenib targets RIPK3",
"source_label": "dabrafenib",
"target_label": "RIPK3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "Inhibition of human RIPK3 using MBP as substrate by [gamma33-ATP] based radiometric assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "23235",
"properties": {
"id": "dabrafenib targets SIK2",
"source_label": "dabrafenib",
"target_label": "SIK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "8711",
"properties": {
"id": "dabrafenib targets TNK1",
"source_label": "dabrafenib",
"target_label": "TNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.18",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "8408",
"properties": {
"id": "dabrafenib targets ULK1",
"source_label": "dabrafenib",
"target_label": "ULK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.73",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44462760",
"relation": "IDG (Drug Target)",
"target": "51776",
"properties": {
"id": "dabrafenib targets MAP3K20",
"source_label": "dabrafenib",
"target_label": "MAP3K20",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11707110",
"relation": "IDG (Drug Target)",
"target": "5243",
"properties": {
"id": "trametinib targets ABCB1",
"source_label": "trametinib",
"target_label": "ABCB1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.61",
"act_comment": "Inhibition of ABCB1 in human A2780/ADR cells assessed as potentiation of daunorubicin-induced cytotoxicity measured after 72 hrs by MTT assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11707110",
"relation": "IDG (Drug Target)",
"target": "5604",
"properties": {
"id": "trametinib targets MAP2K1",
"source_label": "trametinib",
"target_label": "MAP2K1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.745",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:11707110",
"relation": "IDG (Drug Target)",
"target": "5605",
"properties": {
"id": "trametinib targets MAP2K2",
"source_label": "trametinib",
"target_label": "MAP2K2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.036",
"act_comment": "nan",
"act_source": "WOMBAT-PK"
}
},
{
"source": "CID:54726191",
"relation": "IDG (Drug Target)",
"target": "27346",
"properties": {
"id": "dolutegravir targets TMEM97",
"source_label": "dolutegravir",
"target_label": "TMEM97",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.75",
"act_comment": "Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor (unknown origin) incubated for 1 hr in presence of (+)SKF10047 by liquid scintillation counting method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9966051",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "vortioxetine targets ADRB1",
"source_label": "vortioxetine",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.34",
"act_comment": "Binding affinity to human beta 1 adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9966051",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "vortioxetine targets ADRB2",
"source_label": "vortioxetine",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "Binding affinity to human beta 2 adrenergic receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9966051",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "vortioxetine targets HRH1",
"source_label": "vortioxetine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Binding affinity to human histamine H1 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9966051",
"relation": "IDG (Drug Target)",
"target": "3274",
"properties": {
"id": "vortioxetine targets HRH2",
"source_label": "vortioxetine",
"target_label": "HRH2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Binding affinity to human histamine H2 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9966051",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "vortioxetine targets HTR1A",
"source_label": "vortioxetine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.824",
"act_comment": "agonist",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9966051",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "vortioxetine targets HTR1B",
"source_label": "vortioxetine",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.481",
"act_comment": "partial agonist",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9966051",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "vortioxetine targets HTR1D",
"source_label": "vortioxetine",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.268",
"act_comment": "Mechanism of Action",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:9966051",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "vortioxetine targets HTR2A",
"source_label": "vortioxetine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Binding affinity to human 5HT2A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9966051",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "vortioxetine targets HTR2C",
"source_label": "vortioxetine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Binding affinity to human 5HT2C receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9966051",
"relation": "IDG (Drug Target)",
"target": "3359",
"properties": {
"id": "vortioxetine targets HTR3A",
"source_label": "vortioxetine",
"target_label": "HTR3A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.432",
"act_comment": "antagonist",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9966051",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "vortioxetine targets HTR5A",
"source_label": "vortioxetine",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Binding affinity to human 5HT5A receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9966051",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "vortioxetine targets HTR6",
"source_label": "vortioxetine",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Binding affinity to human 5HT6 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9966051",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "vortioxetine targets HTR7",
"source_label": "vortioxetine",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.721",
"act_comment": "antagonist",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9966051",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "vortioxetine targets SLC6A4",
"source_label": "vortioxetine",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.796",
"act_comment": "inhibitor",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11304743",
"relation": "IDG (Drug Target)",
"target": "2983",
"properties": {
"id": "riociguat targets GUCY1B1",
"source_label": "riociguat",
"target_label": "GUCY1B1",
"act_type": "MEC",
"act_relation": "=",
"act_value": "7.523",
"act_comment": "minimal effective concentration to achieve threefold stimulation of cGMP formation in a recombinant sGC-overexpressing cell line",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:604519",
"relation": "IDG (Drug Target)",
"target": "43",
"properties": {
"id": "ipidacrine targets ACHE",
"source_label": "ipidacrine",
"target_label": "ACHE",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.18",
"act_comment": "In vitro inhibition of acetylcholinesterase isolated from human erythrocytes.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16004692",
"relation": "IDG (Drug Target)",
"target": "1909",
"properties": {
"id": "macitentan targets EDNRA",
"source_label": "macitentan",
"target_label": "EDNRA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.301",
"act_comment": "IC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETA",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:16004692",
"relation": "IDG (Drug Target)",
"target": "1910",
"properties": {
"id": "macitentan targets EDNRB",
"source_label": "macitentan",
"target_label": "EDNRB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.408",
"act_comment": "IC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETB",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "ibrutinib targets ABL1",
"source_label": "ibrutinib",
"target_label": "ABL1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.07",
"act_comment": "HotSpot kinase assay: IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 \u00ce\u00bcM ATP.). For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kinase assay. Reaction conditions were 1 uM ATP, one hour incubation with inhibitor, and kinase activity detected using 33-ATP phosphorylation of an appropriately selected peptide substrate.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "27",
"properties": {
"id": "ibrutinib targets ABL2",
"source_label": "ibrutinib",
"target_label": "ABL2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "640",
"properties": {
"id": "ibrutinib targets BLK",
"source_label": "ibrutinib",
"target_label": "BLK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.0",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "660",
"properties": {
"id": "ibrutinib targets BMX",
"source_label": "ibrutinib",
"target_label": "BMX",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "Inhibition of BMX",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "695",
"properties": {
"id": "ibrutinib targets BTK",
"source_label": "ibrutinib",
"target_label": "BTK",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.143",
"act_comment": "measured in anti-IgM stimulated Ramos human B cell line",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "1445",
"properties": {
"id": "ibrutinib targets CSK",
"source_label": "ibrutinib",
"target_label": "CSK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.66",
"act_comment": "HotSpot kinase assay: IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 \u00ce\u00bcM ATP.). For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kinase assay. Reaction conditions were 1 uM ATP, one hour incubation with inhibitor, and kinase activity detected using 33-ATP phosphorylation of an appropriately selected peptide substrate.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "ibrutinib targets EGFR",
"source_label": "ibrutinib",
"target_label": "EGFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.25",
"act_comment": "Inhibition of ErbB1 relative to control",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "2064",
"properties": {
"id": "ibrutinib targets ERBB2",
"source_label": "ibrutinib",
"target_label": "ERBB2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.194",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "2066",
"properties": {
"id": "ibrutinib targets ERBB4",
"source_label": "ibrutinib",
"target_label": "ERBB4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.469",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "84293",
"properties": {
"id": "ibrutinib targets PRXL2A",
"source_label": "ibrutinib",
"target_label": "PRXL2A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Inhibition of PF-06658607 binding to recombinant C-terminal FLAG-tagged FAM213A (unknown origin) expressed in HEK293T cells after 1 hr by gel-based ABPP assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "2263",
"properties": {
"id": "ibrutinib targets FGFR2",
"source_label": "ibrutinib",
"target_label": "FGFR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "2268",
"properties": {
"id": "ibrutinib targets FGR",
"source_label": "ibrutinib",
"target_label": "FGR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.481",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "2444",
"properties": {
"id": "ibrutinib targets FRK",
"source_label": "ibrutinib",
"target_label": "FRK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.23",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "2534",
"properties": {
"id": "ibrutinib targets FYN",
"source_label": "ibrutinib",
"target_label": "FYN",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.538",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "3055",
"properties": {
"id": "ibrutinib targets HCK",
"source_label": "ibrutinib",
"target_label": "HCK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.538",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "3702",
"properties": {
"id": "ibrutinib targets ITK",
"source_label": "ibrutinib",
"target_label": "ITK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "3718",
"properties": {
"id": "ibrutinib targets JAK3",
"source_label": "ibrutinib",
"target_label": "JAK3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.495",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "ibrutinib targets LCK",
"source_label": "ibrutinib",
"target_label": "LCK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.201",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "4067",
"properties": {
"id": "ibrutinib targets LYN",
"source_label": "ibrutinib",
"target_label": "LYN",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.854",
"act_comment": "measured in anti-IgM stimulated Ramos human B cell line",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "5607",
"properties": {
"id": "ibrutinib targets MAP2K5",
"source_label": "ibrutinib",
"target_label": "MAP2K5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.61",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "5753",
"properties": {
"id": "ibrutinib targets PTK6",
"source_label": "ibrutinib",
"target_label": "PTK6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.48",
"act_comment": "HotSpot kinase assay: IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 \u00ce\u00bcM ATP.). For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kinase assay. Reaction conditions were 1 uM ATP, one hour incubation with inhibitor, and kinase activity detected using 33-ATP phosphorylation of an appropriately selected peptide substrate.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "ibrutinib targets RET",
"source_label": "ibrutinib",
"target_label": "RET",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.43",
"act_comment": "Inhibition of RET",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "ibrutinib targets RIPK2",
"source_label": "ibrutinib",
"target_label": "RIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.24",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "11035",
"properties": {
"id": "ibrutinib targets RIPK3",
"source_label": "ibrutinib",
"target_label": "RIPK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.07",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "6714",
"properties": {
"id": "ibrutinib targets SRC",
"source_label": "ibrutinib",
"target_label": "SRC",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.721",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "7006",
"properties": {
"id": "ibrutinib targets TEC",
"source_label": "ibrutinib",
"target_label": "TEC",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.155",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "7294",
"properties": {
"id": "ibrutinib targets TXK",
"source_label": "ibrutinib",
"target_label": "TXK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.699",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24821094",
"relation": "IDG (Drug Target)",
"target": "7525",
"properties": {
"id": "ibrutinib targets YES1",
"source_label": "ibrutinib",
"target_label": "YES1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.387",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24873435",
"relation": "IDG (Drug Target)",
"target": "1520",
"properties": {
"id": "simeprevir targets CTSS",
"source_label": "simeprevir",
"target_label": "CTSS",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Inhibition of human cathepsin S in human JY cells assessed as p10 accumulation by fluorescence-based assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11504295",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "olodaterol targets ADRB1",
"source_label": "olodaterol",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.33",
"act_comment": "competitive binding experiments against [3H]CGP 12177 in the presence of 5'-guanylyl-imidodiphosphate",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11504295",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "olodaterol targets ADRB2",
"source_label": "olodaterol",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.14",
"act_comment": "competitive binding experiments against [3H]CGP 12177 in the presence of 5'-guanylyl-imidodiphosphate",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:16139342",
"relation": "IDG (Drug Target)",
"target": "2740",
"properties": {
"id": "lixisenatide targets GLP1R",
"source_label": "lixisenatide",
"target_label": "GLP1R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.845",
"act_comment": "CHO cells transfected with the human GLP-1 receptor binding affinity",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11519070",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "umeclidinium targets CHRM1",
"source_label": "umeclidinium",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.796",
"act_comment": "radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11519070",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "umeclidinium targets CHRM2",
"source_label": "umeclidinium",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.824",
"act_comment": "radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11519070",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "umeclidinium targets CHRM3",
"source_label": "umeclidinium",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.222",
"act_comment": "radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11519070",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "umeclidinium targets CHRM4",
"source_label": "umeclidinium",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11519070",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "umeclidinium targets CHRM5",
"source_label": "umeclidinium",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11501341",
"relation": "IDG (Drug Target)",
"target": "351",
"properties": {
"id": "florbetaben F18 targets APP",
"source_label": "florbetaben F18",
"target_label": "APP",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.65",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10220503",
"relation": "IDG (Drug Target)",
"target": "4543",
"properties": {
"id": "tasimelteon targets MTNR1A",
"source_label": "tasimelteon",
"target_label": "MTNR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.45",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:10220503",
"relation": "IDG (Drug Target)",
"target": "4544",
"properties": {
"id": "tasimelteon targets MTNR1B",
"source_label": "tasimelteon",
"target_label": "MTNR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.8",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:16132297",
"relation": "IDG (Drug Target)",
"target": "4158",
"properties": {
"id": "seractide targets MC2R",
"source_label": "seractide",
"target_label": "MC2R",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.009",
"act_comment": "125I-ACTH binding in OS3 cells expressing hMC2R wild type",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11561674",
"relation": "IDG (Drug Target)",
"target": "5141",
"properties": {
"id": "apremilast targets PDE4A",
"source_label": "apremilast",
"target_label": "PDE4A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Potency against recombinant human PDE4A1A isoform in a TR-FRET assay.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11561674",
"relation": "IDG (Drug Target)",
"target": "5142",
"properties": {
"id": "apremilast targets PDE4B",
"source_label": "apremilast",
"target_label": "PDE4B",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.57",
"act_comment": "Potency against recombinant human PDE4B1 and B2 isoforms in a TR-FRET assay.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11561674",
"relation": "IDG (Drug Target)",
"target": "5143",
"properties": {
"id": "apremilast targets PDE4C",
"source_label": "apremilast",
"target_label": "PDE4C",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.93",
"act_comment": "Potency against recombinant human PDE4C1 isoform in a TR-FRET assay.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11561674",
"relation": "IDG (Drug Target)",
"target": "5144",
"properties": {
"id": "apremilast targets PDE4D",
"source_label": "apremilast",
"target_label": "PDE4D",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.131",
"act_comment": "PDE4 enzyme isolated from U937 cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11949646",
"relation": "IDG (Drug Target)",
"target": "6524",
"properties": {
"id": "empagliflozin targets SLC5A2",
"source_label": "empagliflozin",
"target_label": "SLC5A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.244",
"act_comment": "[3H]-empagliflozin kinetic binding experiment",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11953153",
"relation": "IDG (Drug Target)",
"target": "1803",
"properties": {
"id": "gemigliptin targets DPP4",
"source_label": "gemigliptin",
"target_label": "DPP4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "fluorometric assay with Gly-Pro-AMC substrate",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:23652731",
"relation": "IDG (Drug Target)",
"target": "7357",
"properties": {
"id": "eliglustat targets UGCG",
"source_label": "eliglustat",
"target_label": "UGCG",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.827",
"act_comment": "inhibition of GlcCer synthesis in disrupted wild-type MDCK cell preparations",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:16132139",
"relation": "IDG (Drug Target)",
"target": "100",
"properties": {
"id": "afamelanotide targets ADA",
"source_label": "afamelanotide",
"target_label": "ADA",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "Inhibition of human adenosine deaminase (ADA)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16132139",
"relation": "IDG (Drug Target)",
"target": "4157",
"properties": {
"id": "afamelanotide targets MC1R",
"source_label": "afamelanotide",
"target_label": "MC1R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:16132139",
"relation": "IDG (Drug Target)",
"target": "4159",
"properties": {
"id": "afamelanotide targets MC3R",
"source_label": "afamelanotide",
"target_label": "MC3R",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:16132139",
"relation": "IDG (Drug Target)",
"target": "4160",
"properties": {
"id": "afamelanotide targets MC4R",
"source_label": "afamelanotide",
"target_label": "MC4R",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:16132139",
"relation": "IDG (Drug Target)",
"target": "4161",
"properties": {
"id": "afamelanotide targets MC5R",
"source_label": "afamelanotide",
"target_label": "MC5R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:72942017",
"relation": "IDG (Drug Target)",
"target": "1394",
"properties": {
"id": "corticorelin targets CRHR1",
"source_label": "corticorelin",
"target_label": "CRHR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.481",
"act_comment": "COS cells binding human CRF",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:72942017",
"relation": "IDG (Drug Target)",
"target": "1395",
"properties": {
"id": "corticorelin targets CRHR2",
"source_label": "corticorelin",
"target_label": "CRHR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6917779",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "levomilnacipran targets SLC6A2",
"source_label": "levomilnacipran",
"target_label": "SLC6A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.035",
"act_comment": "radioligand binding in HEK-293 cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:6917779",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "levomilnacipran targets SLC6A4",
"source_label": "levomilnacipran",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.951",
"act_comment": "radioligand binding in HEK-293 cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "5243",
"properties": {
"id": "ceritinib targets ABCB1",
"source_label": "ceritinib",
"target_label": "ABCB1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.05",
"act_comment": "Inhibition of ABCB1 in human A2780/ADR cells assessed as potentiation of daunorubicin-induced cytotoxicity measured after 72 hrs by MTT assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "238",
"properties": {
"id": "ceritinib targets ALK",
"source_label": "ceritinib",
"target_label": "ALK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.699",
"act_comment": "in vitro enzymatic activity",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "814",
"properties": {
"id": "ceritinib targets CAMK4",
"source_label": "ceritinib",
"target_label": "CAMK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "ceritinib targets EGFR",
"source_label": "ceritinib",
"target_label": "EGFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Inhibition of EGFR (unknown origin) after 60 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "2241",
"properties": {
"id": "ceritinib targets FER",
"source_label": "ceritinib",
"target_label": "FER",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.67",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "2263",
"properties": {
"id": "ceritinib targets FGFR2",
"source_label": "ceritinib",
"target_label": "FGFR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "Inhibition of FGFR2 (unknown origin) after 60 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "2261",
"properties": {
"id": "ceritinib targets FGFR3",
"source_label": "ceritinib",
"target_label": "FGFR3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "Inhibition of FGFR3 (unknown origin) after 60 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "2264",
"properties": {
"id": "ceritinib targets FGFR4",
"source_label": "ceritinib",
"target_label": "FGFR4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "Inhibition of FGFR4 (unknown origin) after 60 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "ceritinib targets FLT3",
"source_label": "ceritinib",
"target_label": "FLT3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.22",
"act_comment": "Inhibition of FLT3 (unknown origin) after 60 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "3480",
"properties": {
"id": "ceritinib targets IGF1R",
"source_label": "ceritinib",
"target_label": "IGF1R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.097",
"act_comment": "in vitro enzymatic activity",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "3643",
"properties": {
"id": "ceritinib targets INSR",
"source_label": "ceritinib",
"target_label": "INSR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.155",
"act_comment": "in vitro enzymatic activity",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "3717",
"properties": {
"id": "ceritinib targets JAK2",
"source_label": "ceritinib",
"target_label": "JAK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Inhibition of JAK2 (unknown origin) after 60 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "ceritinib targets LCK",
"source_label": "ceritinib",
"target_label": "LCK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "Inhibition of LCK (unknown origin) after 60 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "4067",
"properties": {
"id": "ceritinib targets LYN",
"source_label": "ceritinib",
"target_label": "LYN",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.08",
"act_comment": "Inhibition of LYN (unknown origin) after 60 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "5747",
"properties": {
"id": "ceritinib targets PTK2",
"source_label": "ceritinib",
"target_label": "PTK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "ceritinib targets RET",
"source_label": "ceritinib",
"target_label": "RET",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Inhibition of RET (unknown origin) after 60 mins",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "6098",
"properties": {
"id": "ceritinib targets ROS1",
"source_label": "ceritinib",
"target_label": "ROS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Inhibition of TEL-fused ROS (unknown origin) by cell-based assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "8711",
"properties": {
"id": "ceritinib targets TNK1",
"source_label": "ceritinib",
"target_label": "TNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.57",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "10188",
"properties": {
"id": "ceritinib targets TNK2",
"source_label": "ceritinib",
"target_label": "TNK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:57379345",
"relation": "IDG (Drug Target)",
"target": "83942",
"properties": {
"id": "ceritinib targets TSSK1B",
"source_label": "ceritinib",
"target_label": "TSSK1B",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.638",
"act_comment": "in vitro enzymatic activity",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9906855",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "dexrabeprazole targets ADRA2B",
"source_label": "dexrabeprazole",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9906855",
"relation": "IDG (Drug Target)",
"target": "780",
"properties": {
"id": "dexrabeprazole targets DDR1",
"source_label": "dexrabeprazole",
"target_label": "DDR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9906855",
"relation": "IDG (Drug Target)",
"target": "4921",
"properties": {
"id": "dexrabeprazole targets DDR2",
"source_label": "dexrabeprazole",
"target_label": "DDR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.03",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9906855",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "dexrabeprazole targets DRD3",
"source_label": "dexrabeprazole",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9906855",
"relation": "IDG (Drug Target)",
"target": "2260",
"properties": {
"id": "dexrabeprazole targets FGFR1",
"source_label": "dexrabeprazole",
"target_label": "FGFR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.76",
"act_comment": "Inhibition of FGFR1 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9906855",
"relation": "IDG (Drug Target)",
"target": "2263",
"properties": {
"id": "dexrabeprazole targets FGFR2",
"source_label": "dexrabeprazole",
"target_label": "FGFR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.08",
"act_comment": "Inhibition of FGFR2 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9906855",
"relation": "IDG (Drug Target)",
"target": "2261",
"properties": {
"id": "dexrabeprazole targets FGFR3",
"source_label": "dexrabeprazole",
"target_label": "FGFR3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Inhibition of FGFR3 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9906855",
"relation": "IDG (Drug Target)",
"target": "2321",
"properties": {
"id": "dexrabeprazole targets FLT1",
"source_label": "dexrabeprazole",
"target_label": "FLT1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.15",
"act_comment": "Inhibition of VEGFR1 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9906855",
"relation": "IDG (Drug Target)",
"target": "2324",
"properties": {
"id": "dexrabeprazole targets FLT4",
"source_label": "dexrabeprazole",
"target_label": "FLT4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Inhibition of VEGFR3 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9906855",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "dexrabeprazole targets KDR",
"source_label": "dexrabeprazole",
"target_label": "KDR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "Inhibition of VEGFR2 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9906855",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "dexrabeprazole targets PDGFRB",
"source_label": "dexrabeprazole",
"target_label": "PDGFRB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.56",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9906855",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "dexrabeprazole targets RET",
"source_label": "dexrabeprazole",
"target_label": "RET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9906855",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "dexrabeprazole targets RIPK2",
"source_label": "dexrabeprazole",
"target_label": "RIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10077130",
"relation": "IDG (Drug Target)",
"target": "2149",
"properties": {
"id": "vorapaxar targets F2R",
"source_label": "vorapaxar",
"target_label": "F2R",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.092",
"act_comment": "antagonist",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:6918638",
"relation": "IDG (Drug Target)",
"target": "23476",
"properties": {
"id": "belinostat targets BRD4",
"source_label": "belinostat",
"target_label": "BRD4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.57",
"act_comment": "Inhibition of BRD4 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918638",
"relation": "IDG (Drug Target)",
"target": "3065",
"properties": {
"id": "belinostat targets HDAC1",
"source_label": "belinostat",
"target_label": "HDAC1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.07",
"act_comment": "Inhibition of human HDAC1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918638",
"relation": "IDG (Drug Target)",
"target": "83933",
"properties": {
"id": "belinostat targets HDAC10",
"source_label": "belinostat",
"target_label": "HDAC10",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.23",
"act_comment": "Competitive inhibition of HDAC10 using KI-104 as substrate by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918638",
"relation": "IDG (Drug Target)",
"target": "79885",
"properties": {
"id": "belinostat targets HDAC11",
"source_label": "belinostat",
"target_label": "HDAC11",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.57",
"act_comment": "Competitive inhibition of HDAC11 using KI-104 as substrate by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918638",
"relation": "IDG (Drug Target)",
"target": "3066",
"properties": {
"id": "belinostat targets HDAC2",
"source_label": "belinostat",
"target_label": "HDAC2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.07",
"act_comment": "Inhibition of human HDAC2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918638",
"relation": "IDG (Drug Target)",
"target": "8841",
"properties": {
"id": "belinostat targets HDAC3",
"source_label": "belinostat",
"target_label": "HDAC3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.82",
"act_comment": "Inhibition of human HDAC3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918638",
"relation": "IDG (Drug Target)",
"target": "9759",
"properties": {
"id": "belinostat targets HDAC4",
"source_label": "belinostat",
"target_label": "HDAC4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.569",
"act_comment": "histone deacetylase activity in vitro in HeLa cell extracts",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:6918638",
"relation": "IDG (Drug Target)",
"target": "10014",
"properties": {
"id": "belinostat targets HDAC5",
"source_label": "belinostat",
"target_label": "HDAC5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "Competitive inhibition of HDAC5 using KI-104 as substrate by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918638",
"relation": "IDG (Drug Target)",
"target": "10013",
"properties": {
"id": "belinostat targets HDAC6",
"source_label": "belinostat",
"target_label": "HDAC6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "Inhibition of human HDAC6",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918638",
"relation": "IDG (Drug Target)",
"target": "51564",
"properties": {
"id": "belinostat targets HDAC7",
"source_label": "belinostat",
"target_label": "HDAC7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.29",
"act_comment": "Competitive inhibition of HDAC7 using KI-104 as substrate by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918638",
"relation": "IDG (Drug Target)",
"target": "55869",
"properties": {
"id": "belinostat targets HDAC8",
"source_label": "belinostat",
"target_label": "HDAC8",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.66",
"act_comment": "Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:6918638",
"relation": "IDG (Drug Target)",
"target": "9734",
"properties": {
"id": "belinostat targets HDAC9",
"source_label": "belinostat",
"target_label": "HDAC9",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.62",
"act_comment": "Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11499245",
"relation": "IDG (Drug Target)",
"target": "760",
"properties": {
"id": "tavaborole targets CA2",
"source_label": "tavaborole",
"target_label": "CA2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Inhibition of human carbonic anhydrase-2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11625818",
"relation": "IDG (Drug Target)",
"target": "5290",
"properties": {
"id": "idelalisib targets PIK3CA",
"source_label": "idelalisib",
"target_label": "PIK3CA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.086",
"act_comment": "in vitro Invitrogen SelectScreen kinase inhibitor assay",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11625818",
"relation": "IDG (Drug Target)",
"target": "5291",
"properties": {
"id": "idelalisib targets PIK3CB",
"source_label": "idelalisib",
"target_label": "PIK3CB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.248",
"act_comment": "in vitro Invitrogen SelectScreen kinase inhibitor assay",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11625818",
"relation": "IDG (Drug Target)",
"target": "5293",
"properties": {
"id": "idelalisib targets PIK3CD",
"source_label": "idelalisib",
"target_label": "PIK3CD",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.602",
"act_comment": "in vitro Invitrogen SelectScreen kinase inhibitor assay",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11625818",
"relation": "IDG (Drug Target)",
"target": "5294",
"properties": {
"id": "idelalisib targets PIK3CG",
"source_label": "idelalisib",
"target_label": "PIK3CG",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.051",
"act_comment": "in vitro Invitrogen SelectScreen kinase inhibitor assay",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24965990",
"relation": "IDG (Drug Target)",
"target": "3061",
"properties": {
"id": "suvorexant targets HCRTR1",
"source_label": "suvorexant",
"target_label": "HCRTR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.26",
"act_comment": "radioligand-displacement binding assay",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24965990",
"relation": "IDG (Drug Target)",
"target": "3062",
"properties": {
"id": "suvorexant targets HCRTR2",
"source_label": "suvorexant",
"target_label": "HCRTR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.456",
"act_comment": "radioligand-displacement binding assay",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5311037",
"relation": "IDG (Drug Target)",
"target": "134",
"properties": {
"id": "istradefylline targets ADORA1",
"source_label": "istradefylline",
"target_label": "ADORA1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.08",
"act_comment": "Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells after 90 mins by liquid scintillation counting analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311037",
"relation": "IDG (Drug Target)",
"target": "135",
"properties": {
"id": "istradefylline targets ADORA2A",
"source_label": "istradefylline",
"target_label": "ADORA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.66",
"act_comment": "Binding affinity towards human Adenosine A2a receptor expressed in HEK293 cells using 6 nM [3H]CGS-21680",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5311037",
"relation": "IDG (Drug Target)",
"target": "4129",
"properties": {
"id": "istradefylline targets MAOB",
"source_label": "istradefylline",
"target_label": "MAOB",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.57",
"act_comment": "Inhibition of human MAOB",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9952916",
"relation": "IDG (Drug Target)",
"target": "5406",
"properties": {
"id": "cetilistat targets PNLIP",
"source_label": "cetilistat",
"target_label": "PNLIP",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.225",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5288320",
"relation": "IDG (Drug Target)",
"target": "7498",
"properties": {
"id": "topiroxostat targets XDH",
"source_label": "topiroxostat",
"target_label": "XDH",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.276",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:10453870",
"relation": "IDG (Drug Target)",
"target": "6524",
"properties": {
"id": "ipragliflozin targets SLC5A2",
"source_label": "ipragliflozin",
"target_label": "SLC5A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.132",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11988953",
"relation": "IDG (Drug Target)",
"target": "6524",
"properties": {
"id": "luseogliflozin targets SLC5A2",
"source_label": "luseogliflozin",
"target_label": "SLC5A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.646",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:46908929",
"relation": "IDG (Drug Target)",
"target": "6524",
"properties": {
"id": "tofogliflozin targets SLC5A2",
"source_label": "tofogliflozin",
"target_label": "SLC5A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.538",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5287953",
"relation": "IDG (Drug Target)",
"target": "1890",
"properties": {
"id": "tipiracil targets TYMP",
"source_label": "tipiracil",
"target_label": "TYMP",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.699",
"act_comment": "spectrophotometric assay; 5-nitro-2'-deoxyuridine substrate",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11949652",
"relation": "IDG (Drug Target)",
"target": "1803",
"properties": {
"id": "teneligliptin targets DPP4",
"source_label": "teneligliptin",
"target_label": "DPP4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.432",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11949652",
"relation": "IDG (Drug Target)",
"target": "54878",
"properties": {
"id": "teneligliptin targets DPP8",
"source_label": "teneligliptin",
"target_label": "DPP8",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.585",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11949652",
"relation": "IDG (Drug Target)",
"target": "91039",
"properties": {
"id": "teneligliptin targets DPP9",
"source_label": "teneligliptin",
"target_label": "DPP9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.268",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44513473",
"relation": "IDG (Drug Target)",
"target": "1803",
"properties": {
"id": "anagliptin targets DPP4",
"source_label": "anagliptin",
"target_label": "DPP4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.42",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44513473",
"relation": "IDG (Drug Target)",
"target": "54878",
"properties": {
"id": "anagliptin targets DPP8",
"source_label": "anagliptin",
"target_label": "DPP8",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.167",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44513473",
"relation": "IDG (Drug Target)",
"target": "91039",
"properties": {
"id": "anagliptin targets DPP9",
"source_label": "anagliptin",
"target_label": "DPP9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.222",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:10280735",
"relation": "IDG (Drug Target)",
"target": "2159",
"properties": {
"id": "edoxaban targets F10",
"source_label": "edoxaban",
"target_label": "F10",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.252",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:6451149",
"relation": "IDG (Drug Target)",
"target": "6869",
"properties": {
"id": "netupitant targets TACR1",
"source_label": "netupitant",
"target_label": "TACR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.022",
"act_comment": "displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:148197",
"relation": "IDG (Drug Target)",
"target": "5029",
"properties": {
"id": "diquafosol targets P2RY2",
"source_label": "diquafosol",
"target_label": "P2RY2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.469",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:148197",
"relation": "IDG (Drug Target)",
"target": "5030",
"properties": {
"id": "diquafosol targets P2RY4",
"source_label": "diquafosol",
"target_label": "P2RY4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:6433090",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "imidafenacin targets CHRM1",
"source_label": "imidafenacin",
"target_label": "CHRM1",
"act_type": "Kb",
"act_relation": "=",
"act_value": "8.384",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:6433090",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "imidafenacin targets CHRM3",
"source_label": "imidafenacin",
"target_label": "CHRM3",
"act_type": "Kb",
"act_relation": "=",
"act_value": "9.499",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "22848",
"properties": {
"id": "nintedanib targets AAK1",
"source_label": "nintedanib",
"target_label": "AAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "Binding constant for AAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5243",
"properties": {
"id": "nintedanib targets ABCB1",
"source_label": "nintedanib",
"target_label": "ABCB1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.56",
"act_comment": "Inhibition of ABCB1 in human A2780/ADR cells assessed as potentiation of daunorubicin-induced cytotoxicity measured after 72 hrs by MTT assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "nintedanib targets ABL1",
"source_label": "nintedanib",
"target_label": "ABL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Binding constant for ABL1(T315I)-phosphorylated kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "90",
"properties": {
"id": "nintedanib targets ACVR1",
"source_label": "nintedanib",
"target_label": "ACVR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Binding constant for ACVR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "238",
"properties": {
"id": "nintedanib targets ALK",
"source_label": "nintedanib",
"target_label": "ALK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.51",
"act_comment": "Binding constant for ALK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "9212",
"properties": {
"id": "nintedanib targets AURKB",
"source_label": "nintedanib",
"target_label": "AURKB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Binding constant for AURKB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "6795",
"properties": {
"id": "nintedanib targets AURKC",
"source_label": "nintedanib",
"target_label": "AURKC",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Binding constant for AURKC kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "558",
"properties": {
"id": "nintedanib targets AXL",
"source_label": "nintedanib",
"target_label": "AXL",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Binding constant for AXL kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "613",
"properties": {
"id": "nintedanib targets BCR",
"source_label": "nintedanib",
"target_label": "BCR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "640",
"properties": {
"id": "nintedanib targets BLK",
"source_label": "nintedanib",
"target_label": "BLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Binding constant for BLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "55589",
"properties": {
"id": "nintedanib targets BMP2K",
"source_label": "nintedanib",
"target_label": "BMP2K",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.66",
"act_comment": "Binding constant for BIKE kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "659",
"properties": {
"id": "nintedanib targets BMPR2",
"source_label": "nintedanib",
"target_label": "BMPR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.25",
"act_comment": "Binding constant for BMPR2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "695",
"properties": {
"id": "nintedanib targets BTK",
"source_label": "nintedanib",
"target_label": "BTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "Binding constant for BTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "57172",
"properties": {
"id": "nintedanib targets CAMK1G",
"source_label": "nintedanib",
"target_label": "CAMK1G",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "Binding constant for CAMK1G kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "84254",
"properties": {
"id": "nintedanib targets CAMKK1",
"source_label": "nintedanib",
"target_label": "CAMKK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "Binding constant for CAMKK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "10645",
"properties": {
"id": "nintedanib targets CAMKK2",
"source_label": "nintedanib",
"target_label": "CAMKK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "Binding constant for CAMKK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5218",
"properties": {
"id": "nintedanib targets CDK14",
"source_label": "nintedanib",
"target_label": "CDK14",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Binding constant for PFTK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5127",
"properties": {
"id": "nintedanib targets CDK16",
"source_label": "nintedanib",
"target_label": "CDK16",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.68",
"act_comment": "Binding constant for PCTK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5128",
"properties": {
"id": "nintedanib targets CDK17",
"source_label": "nintedanib",
"target_label": "CDK17",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.03",
"act_comment": "Binding constant for PCTK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5129",
"properties": {
"id": "nintedanib targets CDK18",
"source_label": "nintedanib",
"target_label": "CDK18",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "Binding constant for PCTK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "1018",
"properties": {
"id": "nintedanib targets CDK3",
"source_label": "nintedanib",
"target_label": "CDK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.84",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "1019",
"properties": {
"id": "nintedanib targets CDK4",
"source_label": "nintedanib",
"target_label": "CDK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "Binding constant for CDK4-cyclinD1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "1022",
"properties": {
"id": "nintedanib targets CDK7",
"source_label": "nintedanib",
"target_label": "CDK7",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Binding constant for CDK7 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "1111",
"properties": {
"id": "nintedanib targets CHEK1",
"source_label": "nintedanib",
"target_label": "CHEK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Binding constant for CHEK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "1195",
"properties": {
"id": "nintedanib targets CLK1",
"source_label": "nintedanib",
"target_label": "CLK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.06",
"act_comment": "Binding constant for CLK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "1196",
"properties": {
"id": "nintedanib targets CLK2",
"source_label": "nintedanib",
"target_label": "CLK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Binding constant for CLK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "57396",
"properties": {
"id": "nintedanib targets CLK4",
"source_label": "nintedanib",
"target_label": "CLK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.74",
"act_comment": "Binding constant for CLK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "1436",
"properties": {
"id": "nintedanib targets CSF1R",
"source_label": "nintedanib",
"target_label": "CSF1R",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.32",
"act_comment": "Binding constant for CSF1R kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "1454",
"properties": {
"id": "nintedanib targets CSNK1E",
"source_label": "nintedanib",
"target_label": "CSNK1E",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Binding constant for CSNK1E kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "1459",
"properties": {
"id": "nintedanib targets CSNK2A2",
"source_label": "nintedanib",
"target_label": "CSNK2A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Binding constant for CSNK2A2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "9201",
"properties": {
"id": "nintedanib targets DCLK1",
"source_label": "nintedanib",
"target_label": "DCLK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.27",
"act_comment": "Binding constant for DCAMKL1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "85443",
"properties": {
"id": "nintedanib targets DCLK3",
"source_label": "nintedanib",
"target_label": "DCLK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Binding constant for DCAMKL3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "780",
"properties": {
"id": "nintedanib targets DDR1",
"source_label": "nintedanib",
"target_label": "DDR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Binding constant for DDR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "4921",
"properties": {
"id": "nintedanib targets DDR2",
"source_label": "nintedanib",
"target_label": "DDR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.38",
"act_comment": "Binding constant for DDR2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "285220",
"properties": {
"id": "nintedanib targets EPHA6",
"source_label": "nintedanib",
"target_label": "EPHA6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "Binding constant for EPHA6 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "2047",
"properties": {
"id": "nintedanib targets EPHB1",
"source_label": "nintedanib",
"target_label": "EPHB1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "Binding constant for EPHB1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "2051",
"properties": {
"id": "nintedanib targets EPHB6",
"source_label": "nintedanib",
"target_label": "EPHB6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Binding constant for EPHB6 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "2241",
"properties": {
"id": "nintedanib targets FER",
"source_label": "nintedanib",
"target_label": "FER",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.14",
"act_comment": "Binding constant for FER kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "2260",
"properties": {
"id": "nintedanib targets FGFR1",
"source_label": "nintedanib",
"target_label": "FGFR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "2263",
"properties": {
"id": "nintedanib targets FGFR2",
"source_label": "nintedanib",
"target_label": "FGFR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Binding constant for FGFR2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "2261",
"properties": {
"id": "nintedanib targets FGFR3",
"source_label": "nintedanib",
"target_label": "FGFR3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.03",
"act_comment": "Binding constant for FGFR3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "2268",
"properties": {
"id": "nintedanib targets FGR",
"source_label": "nintedanib",
"target_label": "FGR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Binding constant for FGR kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "2321",
"properties": {
"id": "nintedanib targets FLT1",
"source_label": "nintedanib",
"target_label": "FLT1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.983",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "nintedanib targets FLT3",
"source_label": "nintedanib",
"target_label": "FLT3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.38",
"act_comment": "Binding constant for FLT3(D835Y) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "2324",
"properties": {
"id": "nintedanib targets FLT4",
"source_label": "nintedanib",
"target_label": "FLT4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.301",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "2534",
"properties": {
"id": "nintedanib targets FYN",
"source_label": "nintedanib",
"target_label": "FYN",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "Binding constant for FYN kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "6011",
"properties": {
"id": "nintedanib targets GRK1",
"source_label": "nintedanib",
"target_label": "GRK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for GRK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "2868",
"properties": {
"id": "nintedanib targets GRK4",
"source_label": "nintedanib",
"target_label": "GRK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "Binding constant for GRK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "2931",
"properties": {
"id": "nintedanib targets GSK3A",
"source_label": "nintedanib",
"target_label": "GSK3A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "Binding constant for GSK3A kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "2932",
"properties": {
"id": "nintedanib targets GSK3B",
"source_label": "nintedanib",
"target_label": "GSK3B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.08",
"act_comment": "Binding constant for GSK3B kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "28996",
"properties": {
"id": "nintedanib targets HIPK2",
"source_label": "nintedanib",
"target_label": "HIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Binding constant for HIPK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "10114",
"properties": {
"id": "nintedanib targets HIPK3",
"source_label": "nintedanib",
"target_label": "HIPK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "Binding constant for HIPK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "3480",
"properties": {
"id": "nintedanib targets IGF1R",
"source_label": "nintedanib",
"target_label": "IGF1R",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.21",
"act_comment": "Binding constant for IGF1R kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "9641",
"properties": {
"id": "nintedanib targets IKBKE",
"source_label": "nintedanib",
"target_label": "IKBKE",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Binding constant for IKK-epsilon kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "3643",
"properties": {
"id": "nintedanib targets INSR",
"source_label": "nintedanib",
"target_label": "INSR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.62",
"act_comment": "Binding constant for INSR kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "3645",
"properties": {
"id": "nintedanib targets INSRR",
"source_label": "nintedanib",
"target_label": "INSRR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.68",
"act_comment": "Binding constant for INSRR kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "3654",
"properties": {
"id": "nintedanib targets IRAK1",
"source_label": "nintedanib",
"target_label": "IRAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Binding constant for IRAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "51135",
"properties": {
"id": "nintedanib targets IRAK4",
"source_label": "nintedanib",
"target_label": "IRAK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Binding constant for IRAK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "3702",
"properties": {
"id": "nintedanib targets ITK",
"source_label": "nintedanib",
"target_label": "ITK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Binding constant for ITK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "3716",
"properties": {
"id": "nintedanib targets JAK1",
"source_label": "nintedanib",
"target_label": "JAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.32",
"act_comment": "Binding constant for JAK1(JH2domain-pseudokinase) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "3717",
"properties": {
"id": "nintedanib targets JAK2",
"source_label": "nintedanib",
"target_label": "JAK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Binding constant for JAK2(JH1domain-catalytic) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "3718",
"properties": {
"id": "nintedanib targets JAK3",
"source_label": "nintedanib",
"target_label": "JAK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.09",
"act_comment": "Binding constant for JAK3(JH1domain-catalytic) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "3757",
"properties": {
"id": "nintedanib targets KCNH2",
"source_label": "nintedanib",
"target_label": "KCNH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.59",
"act_comment": "Inhibition of human ERG",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "nintedanib targets KDR",
"source_label": "nintedanib",
"target_label": "KDR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.301",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "nintedanib targets KIT",
"source_label": "nintedanib",
"target_label": "KIT",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.57",
"act_comment": "Binding constant for KIT(L576P) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "9113",
"properties": {
"id": "nintedanib targets LATS1",
"source_label": "nintedanib",
"target_label": "LATS1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Binding constant for LATS1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "26524",
"properties": {
"id": "nintedanib targets LATS2",
"source_label": "nintedanib",
"target_label": "LATS2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Binding constant for LATS2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "nintedanib targets LCK",
"source_label": "nintedanib",
"target_label": "LCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.21",
"act_comment": "Binding constant for LCK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "120892",
"properties": {
"id": "nintedanib targets LRRK2",
"source_label": "nintedanib",
"target_label": "LRRK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.43",
"act_comment": "Binding constant for LRRK2(G2019S) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "4058",
"properties": {
"id": "nintedanib targets LTK",
"source_label": "nintedanib",
"target_label": "LTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "Binding constant for LTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "4067",
"properties": {
"id": "nintedanib targets LYN",
"source_label": "nintedanib",
"target_label": "LYN",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "Binding constant for LYN kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5604",
"properties": {
"id": "nintedanib targets MAP2K1",
"source_label": "nintedanib",
"target_label": "MAP2K1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Binding constant for MEK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5605",
"properties": {
"id": "nintedanib targets MAP2K2",
"source_label": "nintedanib",
"target_label": "MAP2K2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.38",
"act_comment": "Binding constant for MEK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5607",
"properties": {
"id": "nintedanib targets MAP2K5",
"source_label": "nintedanib",
"target_label": "MAP2K5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.74",
"act_comment": "Binding constant for MEK5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "4296",
"properties": {
"id": "nintedanib targets MAP3K11",
"source_label": "nintedanib",
"target_label": "MAP3K11",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.15",
"act_comment": "Binding constant for MLK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "7786",
"properties": {
"id": "nintedanib targets MAP3K12",
"source_label": "nintedanib",
"target_label": "MAP3K12",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Binding constant for DLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "9175",
"properties": {
"id": "nintedanib targets MAP3K13",
"source_label": "nintedanib",
"target_label": "MAP3K13",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Binding constant for LZK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "80122",
"properties": {
"id": "nintedanib targets MAP3K19",
"source_label": "nintedanib",
"target_label": "MAP3K19",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.28",
"act_comment": "Binding constant for YSK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "10746",
"properties": {
"id": "nintedanib targets MAP3K2",
"source_label": "nintedanib",
"target_label": "MAP3K2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.03",
"act_comment": "Binding constant for MAP3K2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "4215",
"properties": {
"id": "nintedanib targets MAP3K3",
"source_label": "nintedanib",
"target_label": "MAP3K3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.47",
"act_comment": "Binding constant for MAP3K3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "6885",
"properties": {
"id": "nintedanib targets MAP3K7",
"source_label": "nintedanib",
"target_label": "MAP3K7",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.39",
"act_comment": "Binding constant for TAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "4293",
"properties": {
"id": "nintedanib targets MAP3K9",
"source_label": "nintedanib",
"target_label": "MAP3K9",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Binding constant for MLK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "11184",
"properties": {
"id": "nintedanib targets MAP4K1",
"source_label": "nintedanib",
"target_label": "MAP4K1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.46",
"act_comment": "Binding constant for HPK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5871",
"properties": {
"id": "nintedanib targets MAP4K2",
"source_label": "nintedanib",
"target_label": "MAP4K2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Binding constant for MAP4K2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "8491",
"properties": {
"id": "nintedanib targets MAP4K3",
"source_label": "nintedanib",
"target_label": "MAP4K3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Binding constant for MAP4K3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "9448",
"properties": {
"id": "nintedanib targets MAP4K4",
"source_label": "nintedanib",
"target_label": "MAP4K4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "Binding constant for MAP4K4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "11183",
"properties": {
"id": "nintedanib targets MAP4K5",
"source_label": "nintedanib",
"target_label": "MAP4K5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "Binding constant for MAP4K5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5602",
"properties": {
"id": "nintedanib targets MAPK10",
"source_label": "nintedanib",
"target_label": "MAPK10",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Binding constant for JNK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5599",
"properties": {
"id": "nintedanib targets MAPK8",
"source_label": "nintedanib",
"target_label": "MAPK8",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "Binding constant for JNK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "4140",
"properties": {
"id": "nintedanib targets MARK3",
"source_label": "nintedanib",
"target_label": "MARK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Binding constant for MARK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "9833",
"properties": {
"id": "nintedanib targets MELK",
"source_label": "nintedanib",
"target_label": "MELK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Binding constant for MELK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "10461",
"properties": {
"id": "nintedanib targets MERTK",
"source_label": "nintedanib",
"target_label": "MERTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.07",
"act_comment": "Binding constant for MERTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "4233",
"properties": {
"id": "nintedanib targets MET",
"source_label": "nintedanib",
"target_label": "MET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Binding constant for MET kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "50488",
"properties": {
"id": "nintedanib targets MINK1",
"source_label": "nintedanib",
"target_label": "MINK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.09",
"act_comment": "Binding constant for MINK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "4593",
"properties": {
"id": "nintedanib targets MUSK",
"source_label": "nintedanib",
"target_label": "MUSK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.23",
"act_comment": "Binding constant for MUSK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "4638",
"properties": {
"id": "nintedanib targets MYLK",
"source_label": "nintedanib",
"target_label": "MYLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Binding constant for MYLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "91807",
"properties": {
"id": "nintedanib targets MYLK3",
"source_label": "nintedanib",
"target_label": "MYLK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Binding constant for MLCK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "340156",
"properties": {
"id": "nintedanib targets MYLK4",
"source_label": "nintedanib",
"target_label": "MYLK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Binding constant for MYLK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "4914",
"properties": {
"id": "nintedanib targets NTRK1",
"source_label": "nintedanib",
"target_label": "NTRK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.35",
"act_comment": "Binding constant for TRKA kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "4915",
"properties": {
"id": "nintedanib targets NTRK2",
"source_label": "nintedanib",
"target_label": "NTRK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "Binding constant for TRKB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "4916",
"properties": {
"id": "nintedanib targets NTRK3",
"source_label": "nintedanib",
"target_label": "NTRK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.49",
"act_comment": "Binding constant for TRKC kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "9891",
"properties": {
"id": "nintedanib targets NUAK1",
"source_label": "nintedanib",
"target_label": "NUAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "Binding constant for ARK5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "81788",
"properties": {
"id": "nintedanib targets NUAK2",
"source_label": "nintedanib",
"target_label": "NUAK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.68",
"act_comment": "Binding constant for SNARK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5063",
"properties": {
"id": "nintedanib targets PAK3",
"source_label": "nintedanib",
"target_label": "PAK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Binding constant for PAK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5156",
"properties": {
"id": "nintedanib targets PDGFRA",
"source_label": "nintedanib",
"target_label": "PDGFRA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.745",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "nintedanib targets PDGFRB",
"source_label": "nintedanib",
"target_label": "PDGFRB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.82",
"act_comment": "Binding constant for PDGFRB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5260",
"properties": {
"id": "nintedanib targets PHKG1",
"source_label": "nintedanib",
"target_label": "PHKG1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Binding constant for PHKG1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5261",
"properties": {
"id": "nintedanib targets PHKG2",
"source_label": "nintedanib",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "Binding constant for PHKG2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "8396",
"properties": {
"id": "nintedanib targets PIP4K2B",
"source_label": "nintedanib",
"target_label": "PIP4K2B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "Binding constant for PIP5K2B kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "8394",
"properties": {
"id": "nintedanib targets PIP5K1A",
"source_label": "nintedanib",
"target_label": "PIP5K1A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.31",
"act_comment": "Binding constant for PIP5K1A kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5585",
"properties": {
"id": "nintedanib targets PKN1",
"source_label": "nintedanib",
"target_label": "PKN1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "Binding constant for PKN1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "10733",
"properties": {
"id": "nintedanib targets PLK4",
"source_label": "nintedanib",
"target_label": "PLK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.28",
"act_comment": "Binding constant for PLK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5562",
"properties": {
"id": "nintedanib targets PRKAA1",
"source_label": "nintedanib",
"target_label": "PRKAA1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.06",
"act_comment": "Binding constant for AMPK-alpha1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5563",
"properties": {
"id": "nintedanib targets PRKAA2",
"source_label": "nintedanib",
"target_label": "PRKAA2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.08",
"act_comment": "Binding constant for AMPK-alpha2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5587",
"properties": {
"id": "nintedanib targets PRKD1",
"source_label": "nintedanib",
"target_label": "PRKD1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for PRKD1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "25865",
"properties": {
"id": "nintedanib targets PRKD2",
"source_label": "nintedanib",
"target_label": "PRKD2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Binding constant for PRKD2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "23683",
"properties": {
"id": "nintedanib targets PRKD3",
"source_label": "nintedanib",
"target_label": "PRKD3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Binding constant for PRKD3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5592",
"properties": {
"id": "nintedanib targets PRKG1",
"source_label": "nintedanib",
"target_label": "PRKG1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Binding constant for PRKG1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "8899",
"properties": {
"id": "nintedanib targets PRPF4B",
"source_label": "nintedanib",
"target_label": "PRPF4B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.08",
"act_comment": "Binding constant for PRP4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5747",
"properties": {
"id": "nintedanib targets PTK2",
"source_label": "nintedanib",
"target_label": "PTK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Binding constant for FAK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "2185",
"properties": {
"id": "nintedanib targets PTK2B",
"source_label": "nintedanib",
"target_label": "PTK2B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.09",
"act_comment": "Binding constant for PYK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "nintedanib targets RET",
"source_label": "nintedanib",
"target_label": "RET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.02",
"act_comment": "Binding constant for RET(V804M) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "83732",
"properties": {
"id": "nintedanib targets RIOK1",
"source_label": "nintedanib",
"target_label": "RIOK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.64",
"act_comment": "Binding constant for RIOK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "8780",
"properties": {
"id": "nintedanib targets RIOK3",
"source_label": "nintedanib",
"target_label": "RIOK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.44",
"act_comment": "Binding constant for RIOK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "8737",
"properties": {
"id": "nintedanib targets RIPK1",
"source_label": "nintedanib",
"target_label": "RIPK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding constant for RIPK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "54101",
"properties": {
"id": "nintedanib targets RIPK4",
"source_label": "nintedanib",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Binding constant for RIPK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "6195",
"properties": {
"id": "nintedanib targets RPS6KA1",
"source_label": "nintedanib",
"target_label": "RPS6KA1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Binding constant for RSK1(Kin.Dom.1-N-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "6196",
"properties": {
"id": "nintedanib targets RPS6KA2",
"source_label": "nintedanib",
"target_label": "RPS6KA2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.24",
"act_comment": "Binding constant for RSK3(Kin.Dom.1-N-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "6197",
"properties": {
"id": "nintedanib targets RPS6KA3",
"source_label": "nintedanib",
"target_label": "RPS6KA3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.19",
"act_comment": "Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "8986",
"properties": {
"id": "nintedanib targets RPS6KA4",
"source_label": "nintedanib",
"target_label": "RPS6KA4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Binding constant for RPS6KA4(Kin.Dom.1-N-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "9252",
"properties": {
"id": "nintedanib targets RPS6KA5",
"source_label": "nintedanib",
"target_label": "RPS6KA5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Binding constant for RPS6KA5(Kin.Dom.1-N-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "27330",
"properties": {
"id": "nintedanib targets RPS6KA6",
"source_label": "nintedanib",
"target_label": "RPS6KA6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Binding constant for RSK4(Kin.Dom.1-N-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "6198",
"properties": {
"id": "nintedanib targets RPS6KB1",
"source_label": "nintedanib",
"target_label": "RPS6KB1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Binding constant for S6K1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "388228",
"properties": {
"id": "nintedanib targets SBK1",
"source_label": "nintedanib",
"target_label": "SBK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Binding constant for SBK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "23678",
"properties": {
"id": "nintedanib targets SGK3",
"source_label": "nintedanib",
"target_label": "SGK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding constant for SGK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "150094",
"properties": {
"id": "nintedanib targets SIK1",
"source_label": "nintedanib",
"target_label": "SIK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Binding constant for SIK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "23235",
"properties": {
"id": "nintedanib targets SIK2",
"source_label": "nintedanib",
"target_label": "SIK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Binding constant for SIK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "9748",
"properties": {
"id": "nintedanib targets SLK",
"source_label": "nintedanib",
"target_label": "SLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.29",
"act_comment": "Binding constant for SLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "6714",
"properties": {
"id": "nintedanib targets SRC",
"source_label": "nintedanib",
"target_label": "SRC",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Binding constant for SRC kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "6732",
"properties": {
"id": "nintedanib targets SRPK1",
"source_label": "nintedanib",
"target_label": "SRPK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.43",
"act_comment": "Binding constant for SRPK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "6733",
"properties": {
"id": "nintedanib targets SRPK2",
"source_label": "nintedanib",
"target_label": "SRPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.44",
"act_comment": "Binding constant for SRPK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "26576",
"properties": {
"id": "nintedanib targets SRPK3",
"source_label": "nintedanib",
"target_label": "SRPK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Binding constant for SRPK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "6793",
"properties": {
"id": "nintedanib targets STK10",
"source_label": "nintedanib",
"target_label": "STK10",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.06",
"act_comment": "Binding constant for LOK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "6794",
"properties": {
"id": "nintedanib targets STK11",
"source_label": "nintedanib",
"target_label": "STK11",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.74",
"act_comment": "Binding constant for LKB1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "8576",
"properties": {
"id": "nintedanib targets STK16",
"source_label": "nintedanib",
"target_label": "STK16",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.74",
"act_comment": "Binding constant for STK16 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "9263",
"properties": {
"id": "nintedanib targets STK17A",
"source_label": "nintedanib",
"target_label": "STK17A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Binding constant for DRAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "9262",
"properties": {
"id": "nintedanib targets STK17B",
"source_label": "nintedanib",
"target_label": "STK17B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Binding constant for DRAK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "8428",
"properties": {
"id": "nintedanib targets STK24",
"source_label": "nintedanib",
"target_label": "STK24",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Binding constant for MST3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "51765",
"properties": {
"id": "nintedanib targets STK26",
"source_label": "nintedanib",
"target_label": "STK26",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.31",
"act_comment": "Binding constant for MST4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "6788",
"properties": {
"id": "nintedanib targets STK3",
"source_label": "nintedanib",
"target_label": "STK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.42",
"act_comment": "Binding constant for MST2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "140901",
"properties": {
"id": "nintedanib targets STK35",
"source_label": "nintedanib",
"target_label": "STK35",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Binding constant for STK35 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "27347",
"properties": {
"id": "nintedanib targets STK39",
"source_label": "nintedanib",
"target_label": "STK39",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Binding constant for STK39 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "6789",
"properties": {
"id": "nintedanib targets STK4",
"source_label": "nintedanib",
"target_label": "STK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "Binding constant for MST1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "29110",
"properties": {
"id": "nintedanib targets TBK1",
"source_label": "nintedanib",
"target_label": "TBK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "Binding constant for TBK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "23043",
"properties": {
"id": "nintedanib targets TNIK",
"source_label": "nintedanib",
"target_label": "TNIK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.28",
"act_comment": "Binding constant for TNIK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "8711",
"properties": {
"id": "nintedanib targets TNK1",
"source_label": "nintedanib",
"target_label": "TNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Binding constant for TNK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "7272",
"properties": {
"id": "nintedanib targets TTK",
"source_label": "nintedanib",
"target_label": "TTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.66",
"act_comment": "Binding constant for TTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "7294",
"properties": {
"id": "nintedanib targets TXK",
"source_label": "nintedanib",
"target_label": "TXK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "Binding constant for TXK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "7297",
"properties": {
"id": "nintedanib targets TYK2",
"source_label": "nintedanib",
"target_label": "TYK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.43",
"act_comment": "Binding constant for TYK2(JH1domain-catalytic) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "8408",
"properties": {
"id": "nintedanib targets ULK1",
"source_label": "nintedanib",
"target_label": "ULK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "Binding constant for ULK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "9706",
"properties": {
"id": "nintedanib targets ULK2",
"source_label": "nintedanib",
"target_label": "ULK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Binding constant for ULK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "25989",
"properties": {
"id": "nintedanib targets ULK3",
"source_label": "nintedanib",
"target_label": "ULK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.22",
"act_comment": "Binding constant for ULK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9809715",
"relation": "IDG (Drug Target)",
"target": "7525",
"properties": {
"id": "nintedanib targets YES1",
"source_label": "nintedanib",
"target_label": "YES1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "Binding constant for YES kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9870652",
"relation": "IDG (Drug Target)",
"target": "185",
"properties": {
"id": "fimasartan targets AGTR1",
"source_label": "fimasartan",
"target_label": "AGTR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.377",
"act_comment": "antagonism of angiotensin II induced contraction",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:23725625",
"relation": "IDG (Drug Target)",
"target": "142",
"properties": {
"id": "olaparib targets PARP1",
"source_label": "olaparib",
"target_label": "PARP1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.301",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:23725625",
"relation": "IDG (Drug Target)",
"target": "10038",
"properties": {
"id": "olaparib targets PARP2",
"source_label": "olaparib",
"target_label": "PARP2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:23725625",
"relation": "IDG (Drug Target)",
"target": "10039",
"properties": {
"id": "olaparib targets PARP3",
"source_label": "olaparib",
"target_label": "PARP3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.34",
"act_comment": "Inhibition of PARP3 (unknown origin) using activated DNA as substrate after 1 hr by streptavidin-horseradish peroxidase-based luminescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:23725625",
"relation": "IDG (Drug Target)",
"target": "143",
"properties": {
"id": "olaparib targets PARP4",
"source_label": "olaparib",
"target_label": "PARP4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "Inhibition of recombinant human His6-tagged PARP4 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:23725625",
"relation": "IDG (Drug Target)",
"target": "80351",
"properties": {
"id": "olaparib targets TNKS2",
"source_label": "olaparib",
"target_label": "TNKS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.28",
"act_comment": "Enzyme Assay: In order to test the selectivity of substituents on piperazinotriazole ring within the PARP family, the selectivity of compound S3 and positive compound AZD2281 were tested.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:131682",
"relation": "IDG (Drug Target)",
"target": "4129",
"properties": {
"id": "safinamide targets MAOB",
"source_label": "safinamide",
"target_label": "MAOB",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.347",
"act_comment": "human recombinant MAO B",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:164512663",
"relation": "IDG (Drug Target)",
"target": "2740",
"properties": {
"id": "albiglutide targets GLP1R",
"source_label": "albiglutide",
"target_label": "GLP1R",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.699",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:16132265",
"relation": "IDG (Drug Target)",
"target": "4157",
"properties": {
"id": "corticotropin targets MC1R",
"source_label": "corticotropin",
"target_label": "MC1R",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.6",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:16132265",
"relation": "IDG (Drug Target)",
"target": "4159",
"properties": {
"id": "corticotropin targets MC3R",
"source_label": "corticotropin",
"target_label": "MC3R",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.06",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:16132265",
"relation": "IDG (Drug Target)",
"target": "4160",
"properties": {
"id": "corticotropin targets MC4R",
"source_label": "corticotropin",
"target_label": "MC4R",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:49806720",
"relation": "IDG (Drug Target)",
"target": "51",
"properties": {
"id": "alectinib targets ACOX1",
"source_label": "alectinib",
"target_label": "ACOX1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49806720",
"relation": "IDG (Drug Target)",
"target": "238",
"properties": {
"id": "alectinib targets ALK",
"source_label": "alectinib",
"target_label": "ALK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.721",
"act_comment": "TR-FRET in vitro assay ATP concentration 30uM",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:49806720",
"relation": "IDG (Drug Target)",
"target": "1455",
"properties": {
"id": "alectinib targets CSNK1G2",
"source_label": "alectinib",
"target_label": "CSNK1G2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49806720",
"relation": "IDG (Drug Target)",
"target": "2041",
"properties": {
"id": "alectinib targets EPHA1",
"source_label": "alectinib",
"target_label": "EPHA1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.71",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49806720",
"relation": "IDG (Drug Target)",
"target": "2580",
"properties": {
"id": "alectinib targets GAK",
"source_label": "alectinib",
"target_label": "GAK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49806720",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "alectinib targets RET",
"source_label": "alectinib",
"target_label": "RET",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.319",
"act_comment": "time-resolved fluorescence resonance energy transfer assay to examine each compound\u00e2\u20ac\u2122s ability to phosphorylate substrate peptide Biotin-EGPWLEEEEEAYGWMDF in the presence of the drug and 30 umol/L ATP",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:49806720",
"relation": "IDG (Drug Target)",
"target": "6732",
"properties": {
"id": "alectinib targets SRPK1",
"source_label": "alectinib",
"target_label": "SRPK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.71",
"act_comment": "Inhibition of SRPK1 (unknown origin) by TR-FRET assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9863672",
"relation": "IDG (Drug Target)",
"target": "5585",
"properties": {
"id": "ripasudil targets PKN1",
"source_label": "ripasudil",
"target_label": "PKN1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9863672",
"relation": "IDG (Drug Target)",
"target": "5586",
"properties": {
"id": "ripasudil targets PKN2",
"source_label": "ripasudil",
"target_label": "PKN2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9863672",
"relation": "IDG (Drug Target)",
"target": "6093",
"properties": {
"id": "ripasudil targets ROCK1",
"source_label": "ripasudil",
"target_label": "ROCK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.292",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9863672",
"relation": "IDG (Drug Target)",
"target": "9475",
"properties": {
"id": "ripasudil targets ROCK2",
"source_label": "ripasudil",
"target_label": "ROCK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.721",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5330286",
"relation": "IDG (Drug Target)",
"target": "1019",
"properties": {
"id": "palbociclib targets CDK4",
"source_label": "palbociclib",
"target_label": "CDK4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.959",
"act_comment": "Cdk4/cyclin D1",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5330286",
"relation": "IDG (Drug Target)",
"target": "1021",
"properties": {
"id": "palbociclib targets CDK6",
"source_label": "palbociclib",
"target_label": "CDK6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.824",
"act_comment": "Cdk6/cyclin D2",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:5330286",
"relation": "IDG (Drug Target)",
"target": "1025",
"properties": {
"id": "palbociclib targets CDK9",
"source_label": "palbociclib",
"target_label": "CDK9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Inhibition of CDK9 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5330286",
"relation": "IDG (Drug Target)",
"target": "1195",
"properties": {
"id": "palbociclib targets CLK1",
"source_label": "palbociclib",
"target_label": "CLK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.56",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5330286",
"relation": "IDG (Drug Target)",
"target": "1459",
"properties": {
"id": "palbociclib targets CSNK2A2",
"source_label": "palbociclib",
"target_label": "CSNK2A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.31",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5330286",
"relation": "IDG (Drug Target)",
"target": "3718",
"properties": {
"id": "palbociclib targets JAK3",
"source_label": "palbociclib",
"target_label": "JAK3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "Inhibition of JAK3 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:5330286",
"relation": "IDG (Drug Target)",
"target": "5305",
"properties": {
"id": "palbociclib targets PIP4K2A",
"source_label": "palbociclib",
"target_label": "PIP4K2A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "763",
"properties": {
"id": "lenvatinib targets CA5A",
"source_label": "lenvatinib",
"target_label": "CA5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.88",
"act_comment": "Inhibition of recombinant human carbonic anhydrase VA preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "780",
"properties": {
"id": "lenvatinib targets DDR1",
"source_label": "lenvatinib",
"target_label": "DDR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.34",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "4921",
"properties": {
"id": "lenvatinib targets DDR2",
"source_label": "lenvatinib",
"target_label": "DDR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "2260",
"properties": {
"id": "lenvatinib targets FGFR1",
"source_label": "lenvatinib",
"target_label": "FGFR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.337",
"act_comment": "in vitro kinase activity at 1uM ATP",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "2321",
"properties": {
"id": "lenvatinib targets FLT1",
"source_label": "lenvatinib",
"target_label": "FLT1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.658",
"act_comment": "in vitro kinase activity at 1uM ATP",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "2324",
"properties": {
"id": "lenvatinib targets FLT4",
"source_label": "lenvatinib",
"target_label": "FLT4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.284",
"act_comment": "in vitro kinase activity at 1uM ATP",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "lenvatinib targets KDR",
"source_label": "lenvatinib",
"target_label": "KDR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.398",
"act_comment": "in vitro kinase activity at 1uM ATP",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "lenvatinib targets KIT",
"source_label": "lenvatinib",
"target_label": "KIT",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "in vitro kinase activity at 1uM ATP",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "5871",
"properties": {
"id": "lenvatinib targets MAP4K2",
"source_label": "lenvatinib",
"target_label": "MAP4K2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "1432",
"properties": {
"id": "lenvatinib targets MAPK14",
"source_label": "lenvatinib",
"target_label": "MAPK14",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "9261",
"properties": {
"id": "lenvatinib targets MAPKAPK2",
"source_label": "lenvatinib",
"target_label": "MAPKAPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "5156",
"properties": {
"id": "lenvatinib targets PDGFRA",
"source_label": "lenvatinib",
"target_label": "PDGFRA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.292",
"act_comment": "in vitro kinase activity at 1uM ATP",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "lenvatinib targets PDGFRB",
"source_label": "lenvatinib",
"target_label": "PDGFRB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.409",
"act_comment": "in vitro kinase activity at 1uM ATP",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "5753",
"properties": {
"id": "lenvatinib targets PTK6",
"source_label": "lenvatinib",
"target_label": "PTK6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.76",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "lenvatinib targets RET",
"source_label": "lenvatinib",
"target_label": "RET",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.82",
"act_comment": "Inhibition of RET (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "lenvatinib targets RIPK2",
"source_label": "lenvatinib",
"target_label": "RIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "11035",
"properties": {
"id": "lenvatinib targets RIPK3",
"source_label": "lenvatinib",
"target_label": "RIPK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "6793",
"properties": {
"id": "lenvatinib targets STK10",
"source_label": "lenvatinib",
"target_label": "STK10",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9823820",
"relation": "IDG (Drug Target)",
"target": "23043",
"properties": {
"id": "lenvatinib targets TNIK",
"source_label": "lenvatinib",
"target_label": "TNIK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:3083544",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "arformoterol targets ADRB1",
"source_label": "arformoterol",
"target_label": "ADRB1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.947",
"act_comment": "displacement of [125I]-iodopindololreceptor in Sf9 cells expressing human recombinant beta2",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:3083544",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "arformoterol targets ADRB2",
"source_label": "arformoterol",
"target_label": "ADRB2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.538",
"act_comment": "displacement of [125I]-iodopindololreceptor in Sf9 cells expressing human recombinant beta2",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:3083544",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "arformoterol targets ADRB3",
"source_label": "arformoterol",
"target_label": "ADRB3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "Agonist activity at human beta3 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:12136798",
"relation": "IDG (Drug Target)",
"target": "3065",
"properties": {
"id": "tucidinostat targets HDAC1",
"source_label": "tucidinostat",
"target_label": "HDAC1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.022",
"act_comment": "HDAC enzyme inhibition assay using BSA substrate",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:12136798",
"relation": "IDG (Drug Target)",
"target": "83933",
"properties": {
"id": "tucidinostat targets HDAC10",
"source_label": "tucidinostat",
"target_label": "HDAC10",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.108",
"act_comment": "HDAC enzyme inhibition assay using BSA substrate",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:12136798",
"relation": "IDG (Drug Target)",
"target": "79885",
"properties": {
"id": "tucidinostat targets HDAC11",
"source_label": "tucidinostat",
"target_label": "HDAC11",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.365",
"act_comment": "HDAC enzyme inhibition assay using BSA substrate",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:12136798",
"relation": "IDG (Drug Target)",
"target": "3066",
"properties": {
"id": "tucidinostat targets HDAC2",
"source_label": "tucidinostat",
"target_label": "HDAC2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.796",
"act_comment": "HDAC enzyme inhibition assay using BSA substrate",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:12136798",
"relation": "IDG (Drug Target)",
"target": "8841",
"properties": {
"id": "tucidinostat targets HDAC3",
"source_label": "tucidinostat",
"target_label": "HDAC3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.174",
"act_comment": "HDAC enzyme inhibition assay using BSA substrate",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:12136798",
"relation": "IDG (Drug Target)",
"target": "55869",
"properties": {
"id": "tucidinostat targets HDAC8",
"source_label": "tucidinostat",
"target_label": "HDAC8",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.135",
"act_comment": "HDAC enzyme inhibition assay using BSA substrate",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:222528",
"relation": "IDG (Drug Target)",
"target": "151306",
"properties": {
"id": "deoxycholic acid targets GPBAR1",
"source_label": "deoxycholic acid",
"target_label": "GPBAR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11250029",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "eluxadoline targets OPRD1",
"source_label": "eluxadoline",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.886",
"act_comment": "equivalent to DPDPE in human SK-N-BE cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11250029",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "eluxadoline targets OPRK1",
"source_label": "eluxadoline",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.26",
"act_comment": "Recombinantly expressed human kappa OR",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11250029",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "eluxadoline targets OPRM1",
"source_label": "eluxadoline",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.77",
"act_comment": "Recombinantly expressed human mu OR",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:12001014",
"relation": "IDG (Drug Target)",
"target": "8654",
"properties": {
"id": "mirodenafil targets PDE5A",
"source_label": "mirodenafil",
"target_label": "PDE5A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.469",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9854012",
"relation": "IDG (Drug Target)",
"target": "64805",
"properties": {
"id": "cangrelor targets P2RY12",
"source_label": "cangrelor",
"target_label": "P2RY12",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.627",
"act_comment": "cAMP accumulation in HORK3-expressing cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9854012",
"relation": "IDG (Drug Target)",
"target": "53829",
"properties": {
"id": "cangrelor targets P2RY13",
"source_label": "cangrelor",
"target_label": "P2RY13",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:24775005",
"relation": "IDG (Drug Target)",
"target": "6608",
"properties": {
"id": "sonidegib targets SMO",
"source_label": "sonidegib",
"target_label": "SMO",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.222",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:16678941",
"relation": "IDG (Drug Target)",
"target": "1080",
"properties": {
"id": "lumacaftor targets CFTR",
"source_label": "lumacaftor",
"target_label": "CFTR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.456",
"act_comment": "human bronchial epithelial (HBE) cells with CF homozygous for the F508del CFTR mutation",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9811834",
"relation": "IDG (Drug Target)",
"target": "4311",
"properties": {
"id": "sacubitril targets MME",
"source_label": "sacubitril",
"target_label": "MME",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured after 1 hr by fluorescence based assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:15983988",
"relation": "IDG (Drug Target)",
"target": "1803",
"properties": {
"id": "trelagliptin targets DPP4",
"source_label": "trelagliptin",
"target_label": "DPP4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.398",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "brexpiprazole targets ADRA1A",
"source_label": "brexpiprazole",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.42",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "brexpiprazole targets ADRA1B",
"source_label": "brexpiprazole",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.77",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "brexpiprazole targets ADRA1D",
"source_label": "brexpiprazole",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.585",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "150",
"properties": {
"id": "brexpiprazole targets ADRA2A",
"source_label": "brexpiprazole",
"target_label": "ADRA2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.824",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "151",
"properties": {
"id": "brexpiprazole targets ADRA2B",
"source_label": "brexpiprazole",
"target_label": "ADRA2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "152",
"properties": {
"id": "brexpiprazole targets ADRA2C",
"source_label": "brexpiprazole",
"target_label": "ADRA2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.229",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "153",
"properties": {
"id": "brexpiprazole targets ADRB1",
"source_label": "brexpiprazole",
"target_label": "ADRB1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.229",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "154",
"properties": {
"id": "brexpiprazole targets ADRB2",
"source_label": "brexpiprazole",
"target_label": "ADRB2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.174",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "brexpiprazole targets DRD1",
"source_label": "brexpiprazole",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.796",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "brexpiprazole targets DRD2",
"source_label": "brexpiprazole",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.523",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "brexpiprazole targets DRD3",
"source_label": "brexpiprazole",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.959",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "brexpiprazole targets DRD4",
"source_label": "brexpiprazole",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.201",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "brexpiprazole targets HRH1",
"source_label": "brexpiprazole",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.721",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "brexpiprazole targets HTR1A",
"source_label": "brexpiprazole",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.921",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "brexpiprazole targets HTR1B",
"source_label": "brexpiprazole",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.495",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "brexpiprazole targets HTR2A",
"source_label": "brexpiprazole",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.328",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "brexpiprazole targets HTR2B",
"source_label": "brexpiprazole",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.721",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "brexpiprazole targets HTR2C",
"source_label": "brexpiprazole",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.469",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "brexpiprazole targets HTR5A",
"source_label": "brexpiprazole",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.854",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "3362",
"properties": {
"id": "brexpiprazole targets HTR6",
"source_label": "brexpiprazole",
"target_label": "HTR6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.237",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "brexpiprazole targets HTR7",
"source_label": "brexpiprazole",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.432",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "6530",
"properties": {
"id": "brexpiprazole targets SLC6A2",
"source_label": "brexpiprazole",
"target_label": "SLC6A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.857",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "6531",
"properties": {
"id": "brexpiprazole targets SLC6A3",
"source_label": "brexpiprazole",
"target_label": "SLC6A3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.025",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11978813",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "brexpiprazole targets SLC6A4",
"source_label": "brexpiprazole",
"target_label": "SLC6A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.538",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:6918248",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "flibanserin targets DRD2",
"source_label": "flibanserin",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.516",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:6918248",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "flibanserin targets DRD3",
"source_label": "flibanserin",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.439",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:6918248",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "flibanserin targets DRD4",
"source_label": "flibanserin",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.398",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:6918248",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "flibanserin targets HTR1A",
"source_label": "flibanserin",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:6918248",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "flibanserin targets HTR2A",
"source_label": "flibanserin",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.31",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:6918248",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "flibanserin targets HTR2B",
"source_label": "flibanserin",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.049",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:6918248",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "flibanserin targets HTR2C",
"source_label": "flibanserin",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.054",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:6918248",
"relation": "IDG (Drug Target)",
"target": "3361",
"properties": {
"id": "flibanserin targets HTR5A",
"source_label": "flibanserin",
"target_label": "HTR5A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.093",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:10311306",
"relation": "IDG (Drug Target)",
"target": "6869",
"properties": {
"id": "rolapitant targets TACR1",
"source_label": "rolapitant",
"target_label": "TACR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.18",
"act_comment": "CHO cells expressing the human NK1 receptor",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11154555",
"relation": "IDG (Drug Target)",
"target": "146",
"properties": {
"id": "cariprazine targets ADRA1D",
"source_label": "cariprazine",
"target_label": "ADRA1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "HEK-293 cells, [3H]Prazosin (0.6nM)",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11154555",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "cariprazine targets DRD2",
"source_label": "cariprazine",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.31",
"act_comment": "CHO cells, [3H]Spiperone (0.16nM)",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11154555",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "cariprazine targets DRD3",
"source_label": "cariprazine",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.07",
"act_comment": "CHO cells, [3H]Spiperone (0.7nM)",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11154555",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "cariprazine targets DRD4",
"source_label": "cariprazine",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Displacement of [3H]Spiperone from human dopamine D4.4 receptor expressed in CHO cells by competitive binding assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11154555",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "cariprazine targets HRH1",
"source_label": "cariprazine",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.63",
"act_comment": "CHO-1 cells, [3H]Pyrilamine (1.5nM)",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11154555",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "cariprazine targets HTR1A",
"source_label": "cariprazine",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.59",
"act_comment": "CHO cells, [3H]8-OH-DPAT (1.5nM)",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11154555",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "cariprazine targets HTR2A",
"source_label": "cariprazine",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.73",
"act_comment": "CHO-K1 cells, [3H]Ketanserine (0.5nM)",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11154555",
"relation": "IDG (Drug Target)",
"target": "3357",
"properties": {
"id": "cariprazine targets HTR2B",
"source_label": "cariprazine",
"target_label": "HTR2B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.24",
"act_comment": "CHO-K1 cells, [3H]LSD (1.2nM)",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11154555",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "cariprazine targets HTR2C",
"source_label": "cariprazine",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.87",
"act_comment": "CHO-K1 cells, [3H]Mesulergine (1.0nM)",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11154555",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "cariprazine targets HTR7",
"source_label": "cariprazine",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.95",
"act_comment": "CHO cells, [3H]LSD (1.5nM)",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:16222096",
"relation": "IDG (Drug Target)",
"target": "10096",
"properties": {
"id": "cobimetinib targets ACTR3",
"source_label": "cobimetinib",
"target_label": "ACTR3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.44",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16222096",
"relation": "IDG (Drug Target)",
"target": "673",
"properties": {
"id": "cobimetinib targets BRAF",
"source_label": "cobimetinib",
"target_label": "BRAF",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.74",
"act_comment": "Inhibition of B-raf V600E mutant in human COLO205 cells assessed as reduction of ERK1/ERK2 phosphorylation",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16222096",
"relation": "IDG (Drug Target)",
"target": "5604",
"properties": {
"id": "cobimetinib targets MAP2K1",
"source_label": "cobimetinib",
"target_label": "MAP2K1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.046",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:16222096",
"relation": "IDG (Drug Target)",
"target": "5605",
"properties": {
"id": "cobimetinib targets MAP2K2",
"source_label": "cobimetinib",
"target_label": "MAP2K2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:60151560",
"relation": "IDG (Drug Target)",
"target": "5465",
"properties": {
"id": "saroglitazar targets PPARA",
"source_label": "saroglitazar",
"target_label": "PPARA",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.187",
"act_comment": "PPRE-luc transactivation assay in HepG2 cells transfected with hPPAR-alpha and hPPAR-gamma receptors",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:60151560",
"relation": "IDG (Drug Target)",
"target": "5468",
"properties": {
"id": "saroglitazar targets PPARG",
"source_label": "saroglitazar",
"target_label": "PPARG",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.523",
"act_comment": "PPRE-luc transactivation assay in HepG2 cells transfected with hPPAR-alpha and hPPAR-gamma receptors",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9948102",
"relation": "IDG (Drug Target)",
"target": "11255",
"properties": {
"id": "pitolisant targets HRH3",
"source_label": "pitolisant",
"target_label": "HRH3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.796",
"act_comment": "[35S]GTP-gamma-S binding in HEK-293 cells stably expressing the human H3",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:49831411",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "aripiprazole lauroxil targets DRD2",
"source_label": "aripiprazole lauroxil",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.469",
"act_comment": "Mechanism of Action",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:49831411",
"relation": "IDG (Drug Target)",
"target": "1814",
"properties": {
"id": "aripiprazole lauroxil targets DRD3",
"source_label": "aripiprazole lauroxil",
"target_label": "DRD3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.097",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:49831411",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "aripiprazole lauroxil targets DRD4",
"source_label": "aripiprazole lauroxil",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.357",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:49831411",
"relation": "IDG (Drug Target)",
"target": "3269",
"properties": {
"id": "aripiprazole lauroxil targets HRH1",
"source_label": "aripiprazole lauroxil",
"target_label": "HRH1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.215",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:49831411",
"relation": "IDG (Drug Target)",
"target": "3350",
"properties": {
"id": "aripiprazole lauroxil targets HTR1A",
"source_label": "aripiprazole lauroxil",
"target_label": "HTR1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.77",
"act_comment": "Mechanism of Action",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:49831411",
"relation": "IDG (Drug Target)",
"target": "3351",
"properties": {
"id": "aripiprazole lauroxil targets HTR1B",
"source_label": "aripiprazole lauroxil",
"target_label": "HTR1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:49831411",
"relation": "IDG (Drug Target)",
"target": "3352",
"properties": {
"id": "aripiprazole lauroxil targets HTR1D",
"source_label": "aripiprazole lauroxil",
"target_label": "HTR1D",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:49831411",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "aripiprazole lauroxil targets HTR2A",
"source_label": "aripiprazole lauroxil",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.469",
"act_comment": "Mechanism of Action",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:49831411",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "aripiprazole lauroxil targets HTR2C",
"source_label": "aripiprazole lauroxil",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.824",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:49831411",
"relation": "IDG (Drug Target)",
"target": "3363",
"properties": {
"id": "aripiprazole lauroxil targets HTR7",
"source_label": "aripiprazole lauroxil",
"target_label": "HTR7",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.409",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:46209133",
"relation": "IDG (Drug Target)",
"target": "1803",
"properties": {
"id": "omarigliptin targets DPP4",
"source_label": "omarigliptin",
"target_label": "DPP4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.097",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:49843517",
"relation": "IDG (Drug Target)",
"target": "4352",
"properties": {
"id": "lusutrombopag targets MPL",
"source_label": "lusutrombopag",
"target_label": "MPL",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.076",
"act_comment": "Mechanism of Action; cell proliferation; recombinant human TPO",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:72099",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "esflurbiprofen targets PTGS2",
"source_label": "esflurbiprofen",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71496458",
"relation": "IDG (Drug Target)",
"target": "238",
"properties": {
"id": "osimertinib targets ALK",
"source_label": "osimertinib",
"target_label": "ALK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.75",
"act_comment": "Inhibition of GST-tagged human ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system using Poly G:T (4:1) as substrate after 30 mins by Z-LYTE assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71496458",
"relation": "IDG (Drug Target)",
"target": "695",
"properties": {
"id": "osimertinib targets BTK",
"source_label": "osimertinib",
"target_label": "BTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71496458",
"relation": "IDG (Drug Target)",
"target": "833",
"properties": {
"id": "osimertinib targets CARS1",
"source_label": "osimertinib",
"target_label": "CARS1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71496458",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "osimertinib targets EGFR",
"source_label": "osimertinib",
"target_label": "EGFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.824",
"act_comment": "Inhibition of EGFR phosphorylation in double mutant cell line H1975",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71496458",
"relation": "IDG (Drug Target)",
"target": "2065",
"properties": {
"id": "osimertinib targets ERBB3",
"source_label": "osimertinib",
"target_label": "ERBB3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.68",
"act_comment": "Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71496458",
"relation": "IDG (Drug Target)",
"target": "3643",
"properties": {
"id": "osimertinib targets INSR",
"source_label": "osimertinib",
"target_label": "INSR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71496458",
"relation": "IDG (Drug Target)",
"target": "7006",
"properties": {
"id": "osimertinib targets TEC",
"source_label": "osimertinib",
"target_label": "TEC",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.49",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:37907",
"relation": "IDG (Drug Target)",
"target": "1576",
"properties": {
"id": "climbazole targets CYP3A4",
"source_label": "climbazole",
"target_label": "CYP3A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "null: A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. CYP3A4A is thought to be one of the primary CYP isoforms responsible for retinoic acid metabolism in the skin. Three benchmark agents, liarozole, climbazole, and ketoconazole, were assessed for CYP3A4 inhibition to confirm that the inhibition activity (the IC50 for CYP3A4 inhibition) measured by the assay corresponds to the activity reported by the published literature. The results show that the substituted azole compounds having the specific structure set forth herein are CYP inhibitors, and thus function as RAMBAs.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25183872",
"relation": "IDG (Drug Target)",
"target": "5689",
"properties": {
"id": "ixazomib targets PSMB1",
"source_label": "ixazomib",
"target_label": "PSMB1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.509",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:25183872",
"relation": "IDG (Drug Target)",
"target": "5693",
"properties": {
"id": "ixazomib targets PSMB5",
"source_label": "ixazomib",
"target_label": "PSMB5",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.469",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9837243",
"relation": "IDG (Drug Target)",
"target": "9900",
"properties": {
"id": "brivaracetam targets SV2A",
"source_label": "brivaracetam",
"target_label": "SV2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9913767",
"relation": "IDG (Drug Target)",
"target": "5729",
"properties": {
"id": "selexipag targets PTGDR",
"source_label": "selexipag",
"target_label": "PTGDR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Agonist activity at recombinant human DP1 receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9913767",
"relation": "IDG (Drug Target)",
"target": "5739",
"properties": {
"id": "selexipag targets PTGIR",
"source_label": "selexipag",
"target_label": "PTGIR",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.699",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9826451",
"relation": "IDG (Drug Target)",
"target": "5465",
"properties": {
"id": "lobeglitazone targets PPARA",
"source_label": "lobeglitazone",
"target_label": "PPARA",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.699",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9826451",
"relation": "IDG (Drug Target)",
"target": "5468",
"properties": {
"id": "lobeglitazone targets PPARG",
"source_label": "lobeglitazone",
"target_label": "PPARG",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.745",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:176077",
"relation": "IDG (Drug Target)",
"target": "2717",
"properties": {
"id": "migalastat targets GLA",
"source_label": "migalastat",
"target_label": "GLA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:176077",
"relation": "IDG (Drug Target)",
"target": "6476",
"properties": {
"id": "migalastat targets SI",
"source_label": "migalastat",
"target_label": "SI",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49846579",
"relation": "IDG (Drug Target)",
"target": "596",
"properties": {
"id": "venetoclax targets BCL2",
"source_label": "venetoclax",
"target_label": "BCL2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "11.0",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:49846579",
"relation": "IDG (Drug Target)",
"target": "598",
"properties": {
"id": "venetoclax targets BCL2L1",
"source_label": "venetoclax",
"target_label": "BCL2L1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.319",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:49846579",
"relation": "IDG (Drug Target)",
"target": "599",
"properties": {
"id": "venetoclax targets BCL2L2",
"source_label": "venetoclax",
"target_label": "BCL2L2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.611",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:10071196",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "pimavanserin targets HTR2A",
"source_label": "pimavanserin",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "1 nM [3H]ketanserin binding in cell membranes",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:10071196",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "pimavanserin targets HTR2C",
"source_label": "pimavanserin",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "3 nM [3H]mesulergine binding in cell membranes",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:135565903",
"relation": "IDG (Drug Target)",
"target": "1312",
"properties": {
"id": "opicapone targets COMT",
"source_label": "opicapone",
"target_label": "COMT",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:447715",
"relation": "IDG (Drug Target)",
"target": "151306",
"properties": {
"id": "obeticholic acid targets GPBAR1",
"source_label": "obeticholic acid",
"target_label": "GPBAR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:447715",
"relation": "IDG (Drug Target)",
"target": "9971",
"properties": {
"id": "obeticholic acid targets NR1H4",
"source_label": "obeticholic acid",
"target_label": "NR1H4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.004",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11965427",
"relation": "IDG (Drug Target)",
"target": "3383",
"properties": {
"id": "lifitegrast targets ICAM1",
"source_label": "lifitegrast",
"target_label": "ICAM1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.53",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16063245",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "radotinib targets ABL1",
"source_label": "radotinib",
"target_label": "ABL1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.514",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44591583",
"relation": "IDG (Drug Target)",
"target": "5150",
"properties": {
"id": "crisaborole targets PDE7A",
"source_label": "crisaborole",
"target_label": "PDE7A",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "22848",
"properties": {
"id": "baricitinib targets AAK1",
"source_label": "baricitinib",
"target_label": "AAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "Binding affinity determined in a cell-free biochemical assay.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "55589",
"properties": {
"id": "baricitinib targets BMP2K",
"source_label": "baricitinib",
"target_label": "BMP2K",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "Binding affinity determined in a cell-free biochemical assay.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "817",
"properties": {
"id": "baricitinib targets CAMK2D",
"source_label": "baricitinib",
"target_label": "CAMK2D",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "818",
"properties": {
"id": "baricitinib targets CAMK2G",
"source_label": "baricitinib",
"target_label": "CAMK2G",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.61",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "1195",
"properties": {
"id": "baricitinib targets CLK1",
"source_label": "baricitinib",
"target_label": "CLK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "1455",
"properties": {
"id": "baricitinib targets CSNK1G2",
"source_label": "baricitinib",
"target_label": "CSNK1G2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.58",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "27102",
"properties": {
"id": "baricitinib targets EIF2AK1",
"source_label": "baricitinib",
"target_label": "EIF2AK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "2580",
"properties": {
"id": "baricitinib targets GAK",
"source_label": "baricitinib",
"target_label": "GAK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.87",
"act_comment": "Binding affinity determined in a cell-free biochemical assay.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "3716",
"properties": {
"id": "baricitinib targets JAK1",
"source_label": "baricitinib",
"target_label": "JAK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.229",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "3717",
"properties": {
"id": "baricitinib targets JAK2",
"source_label": "baricitinib",
"target_label": "JAK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.244",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "3718",
"properties": {
"id": "baricitinib targets JAK3",
"source_label": "baricitinib",
"target_label": "JAK3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "nan",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "2011",
"properties": {
"id": "baricitinib targets MARK2",
"source_label": "baricitinib",
"target_label": "MARK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "4140",
"properties": {
"id": "baricitinib targets MARK3",
"source_label": "baricitinib",
"target_label": "MARK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.98",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "5585",
"properties": {
"id": "baricitinib targets PKN1",
"source_label": "baricitinib",
"target_label": "PKN1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.98",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "5586",
"properties": {
"id": "baricitinib targets PKN2",
"source_label": "baricitinib",
"target_label": "PKN2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "baricitinib targets RET",
"source_label": "baricitinib",
"target_label": "RET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "6093",
"properties": {
"id": "baricitinib targets ROCK1",
"source_label": "baricitinib",
"target_label": "ROCK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.32",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "9475",
"properties": {
"id": "baricitinib targets ROCK2",
"source_label": "baricitinib",
"target_label": "ROCK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "10801",
"properties": {
"id": "baricitinib targets SEPTIN9",
"source_label": "baricitinib",
"target_label": "SEPTIN9",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.08",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "8711",
"properties": {
"id": "baricitinib targets TNK1",
"source_label": "baricitinib",
"target_label": "TNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "7297",
"properties": {
"id": "baricitinib targets TYK2",
"source_label": "baricitinib",
"target_label": "TYK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.276",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44205240",
"relation": "IDG (Drug Target)",
"target": "8408",
"properties": {
"id": "baricitinib targets ULK1",
"source_label": "baricitinib",
"target_label": "ULK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9931954",
"relation": "IDG (Drug Target)",
"target": "142",
"properties": {
"id": "rucaparib targets PARP1",
"source_label": "rucaparib",
"target_label": "PARP1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.5",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9931954",
"relation": "IDG (Drug Target)",
"target": "84875",
"properties": {
"id": "rucaparib targets PARP10",
"source_label": "rucaparib",
"target_label": "PARP10",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9931954",
"relation": "IDG (Drug Target)",
"target": "10038",
"properties": {
"id": "rucaparib targets PARP2",
"source_label": "rucaparib",
"target_label": "PARP2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.55",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9931954",
"relation": "IDG (Drug Target)",
"target": "10039",
"properties": {
"id": "rucaparib targets PARP3",
"source_label": "rucaparib",
"target_label": "PARP3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9931954",
"relation": "IDG (Drug Target)",
"target": "143",
"properties": {
"id": "rucaparib targets PARP4",
"source_label": "rucaparib",
"target_label": "PARP4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.08",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9931954",
"relation": "IDG (Drug Target)",
"target": "8658",
"properties": {
"id": "rucaparib targets TNKS",
"source_label": "rucaparib",
"target_label": "TNKS",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.84",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9931954",
"relation": "IDG (Drug Target)",
"target": "80351",
"properties": {
"id": "rucaparib targets TNKS2",
"source_label": "rucaparib",
"target_label": "TNKS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:70693500",
"relation": "IDG (Drug Target)",
"target": "2984",
"properties": {
"id": "plecanatide targets GUCY2C",
"source_label": "plecanatide",
"target_label": "GUCY2C",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.721",
"act_comment": "Stimulation of cGMP synthesis in T84 cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:70693500",
"relation": "IDG (Drug Target)",
"target": "7124",
"properties": {
"id": "plecanatide targets TNF",
"source_label": "plecanatide",
"target_label": "TNF",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.42",
"act_comment": "Binding affinity to TNF-alpha (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:22024915",
"relation": "IDG (Drug Target)",
"target": "833",
"properties": {
"id": "icotinib targets CARS1",
"source_label": "icotinib",
"target_label": "CARS1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:22024915",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "icotinib targets EGFR",
"source_label": "icotinib",
"target_label": "EGFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.699",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:22024915",
"relation": "IDG (Drug Target)",
"target": "2580",
"properties": {
"id": "icotinib targets GAK",
"source_label": "icotinib",
"target_label": "GAK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:22024915",
"relation": "IDG (Drug Target)",
"target": "6793",
"properties": {
"id": "icotinib targets STK10",
"source_label": "icotinib",
"target_label": "STK10",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:54758501",
"relation": "IDG (Drug Target)",
"target": "695",
"properties": {
"id": "olmutinib targets BTK",
"source_label": "olmutinib",
"target_label": "BTK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "Inhibition of BTK (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:54758501",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "olmutinib targets EGFR",
"source_label": "olmutinib",
"target_label": "EGFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.036",
"act_comment": "HCC827 cells expressing EGFR(DEL19)",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11315474",
"relation": "IDG (Drug Target)",
"target": "1445",
"properties": {
"id": "apatinib targets CSK",
"source_label": "apatinib",
"target_label": "CSK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Assay used apatinib mesylate (YN968D1)",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11315474",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "apatinib targets KDR",
"source_label": "apatinib",
"target_label": "KDR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11315474",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "apatinib targets KIT",
"source_label": "apatinib",
"target_label": "KIT",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.368",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11315474",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "apatinib targets RET",
"source_label": "apatinib",
"target_label": "RET",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.886",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11315474",
"relation": "IDG (Drug Target)",
"target": "6714",
"properties": {
"id": "apatinib targets SRC",
"source_label": "apatinib",
"target_label": "SRC",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.276",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:25181577",
"relation": "IDG (Drug Target)",
"target": "7166",
"properties": {
"id": "telotristat ethyl targets TPH1",
"source_label": "telotristat ethyl",
"target_label": "TPH1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44631912",
"relation": "IDG (Drug Target)",
"target": "817",
"properties": {
"id": "ribociclib targets CAMK2D",
"source_label": "ribociclib",
"target_label": "CAMK2D",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.53",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44631912",
"relation": "IDG (Drug Target)",
"target": "818",
"properties": {
"id": "ribociclib targets CAMK2G",
"source_label": "ribociclib",
"target_label": "CAMK2G",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.61",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:44631912",
"relation": "IDG (Drug Target)",
"target": "1019",
"properties": {
"id": "ribociclib targets CDK4",
"source_label": "ribociclib",
"target_label": "CDK4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44631912",
"relation": "IDG (Drug Target)",
"target": "1021",
"properties": {
"id": "ribociclib targets CDK6",
"source_label": "ribociclib",
"target_label": "CDK6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.409",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44631912",
"relation": "IDG (Drug Target)",
"target": "2580",
"properties": {
"id": "ribociclib targets GAK",
"source_label": "ribociclib",
"target_label": "GAK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.18",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:54732242",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "naldemedine targets OPRD1",
"source_label": "naldemedine",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.04",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:54732242",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "naldemedine targets OPRM1",
"source_label": "naldemedine",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.95",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:24958200",
"relation": "IDG (Drug Target)",
"target": "142",
"properties": {
"id": "niraparib targets PARP1",
"source_label": "niraparib",
"target_label": "PARP1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.42",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:24958200",
"relation": "IDG (Drug Target)",
"target": "64761",
"properties": {
"id": "niraparib targets PARP12",
"source_label": "niraparib",
"target_label": "PARP12",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "Inhibition of recombinant human His6-tagged PARP12 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24958200",
"relation": "IDG (Drug Target)",
"target": "10038",
"properties": {
"id": "niraparib targets PARP2",
"source_label": "niraparib",
"target_label": "PARP2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.68",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:24958200",
"relation": "IDG (Drug Target)",
"target": "143",
"properties": {
"id": "niraparib targets PARP4",
"source_label": "niraparib",
"target_label": "PARP4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Inhibition of human v-PARP catalytic domain by trichloroacetic acid precipitation assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24958200",
"relation": "IDG (Drug Target)",
"target": "8658",
"properties": {
"id": "niraparib targets TNKS",
"source_label": "niraparib",
"target_label": "TNKS",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Inhibition of human TANK1 C-terminal domain by trichloroacetic acid precipitation assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24795069",
"relation": "IDG (Drug Target)",
"target": "6571",
"properties": {
"id": "valbenazine targets SLC18A2",
"source_label": "valbenazine",
"target_label": "SLC18A2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.523",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:135409409",
"relation": "IDG (Drug Target)",
"target": "4860",
"properties": {
"id": "forodesine targets PNP",
"source_label": "forodesine",
"target_label": "PNP",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.143",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "22848",
"properties": {
"id": "midostaurin targets AAK1",
"source_label": "midostaurin",
"target_label": "AAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.32",
"act_comment": "Binding constant for AAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "midostaurin targets ABL1",
"source_label": "midostaurin",
"target_label": "ABL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Binding constant for ABL1(T315I)-phosphorylated kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "207",
"properties": {
"id": "midostaurin targets AKT1",
"source_label": "midostaurin",
"target_label": "AKT1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "Binding constant for AKT1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "208",
"properties": {
"id": "midostaurin targets AKT2",
"source_label": "midostaurin",
"target_label": "AKT2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Binding constant for AKT2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "238",
"properties": {
"id": "midostaurin targets ALK",
"source_label": "midostaurin",
"target_label": "ALK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Binding constant for ALK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "6790",
"properties": {
"id": "midostaurin targets AURKA",
"source_label": "midostaurin",
"target_label": "AURKA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "Inhibition of recombinant GST-tagged Aurora-A kinase domain (S123 to S401) (unknown origin) expressed in insect Sf9 cells using tetra(LRRASLG) peptide as substrate after 90 mins by Kinase-Glo assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "9212",
"properties": {
"id": "midostaurin targets AURKB",
"source_label": "midostaurin",
"target_label": "AURKB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.21",
"act_comment": "Binding constant for AURKB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "6795",
"properties": {
"id": "midostaurin targets AURKC",
"source_label": "midostaurin",
"target_label": "AURKC",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Binding constant for full-length AURKC",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "558",
"properties": {
"id": "midostaurin targets AXL",
"source_label": "midostaurin",
"target_label": "AXL",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Binding constant for AXL kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "640",
"properties": {
"id": "midostaurin targets BLK",
"source_label": "midostaurin",
"target_label": "BLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Binding constant for BLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "55589",
"properties": {
"id": "midostaurin targets BMP2K",
"source_label": "midostaurin",
"target_label": "BMP2K",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Binding constant for BIKE kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "9024",
"properties": {
"id": "midostaurin targets BRSK2",
"source_label": "midostaurin",
"target_label": "BRSK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Binding constant for full-length BRSK2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "57118",
"properties": {
"id": "midostaurin targets CAMK1D",
"source_label": "midostaurin",
"target_label": "CAMK1D",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Binding constant for CAMK1D kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "815",
"properties": {
"id": "midostaurin targets CAMK2A",
"source_label": "midostaurin",
"target_label": "CAMK2A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Binding constant for CAMK2A kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "816",
"properties": {
"id": "midostaurin targets CAMK2B",
"source_label": "midostaurin",
"target_label": "CAMK2B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Binding constant for CAMK2B kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "817",
"properties": {
"id": "midostaurin targets CAMK2D",
"source_label": "midostaurin",
"target_label": "CAMK2D",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.44",
"act_comment": "Binding constant for CAMK2D kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "818",
"properties": {
"id": "midostaurin targets CAMK2G",
"source_label": "midostaurin",
"target_label": "CAMK2G",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Binding constant for CAMK2G kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "84254",
"properties": {
"id": "midostaurin targets CAMKK1",
"source_label": "midostaurin",
"target_label": "CAMKK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Binding constant for CAMKK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "10645",
"properties": {
"id": "midostaurin targets CAMKK2",
"source_label": "midostaurin",
"target_label": "CAMKK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.14",
"act_comment": "Binding constant for CAMKK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "1195",
"properties": {
"id": "midostaurin targets CLK1",
"source_label": "midostaurin",
"target_label": "CLK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Binding constant for full-length CLK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "1196",
"properties": {
"id": "midostaurin targets CLK2",
"source_label": "midostaurin",
"target_label": "CLK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "Binding constant for CLK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "57396",
"properties": {
"id": "midostaurin targets CLK4",
"source_label": "midostaurin",
"target_label": "CLK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "Binding constant for CLK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "1436",
"properties": {
"id": "midostaurin targets CSF1R",
"source_label": "midostaurin",
"target_label": "CSF1R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Inhibition of human FMS expressed in growth factor dependent mouse FDC-P1 cells assessed as inhibition of FMS-mediated cell proliferation in presence human CSF1 after 48 hrs by resazurin dye reduction assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "1457",
"properties": {
"id": "midostaurin targets CSNK2A1",
"source_label": "midostaurin",
"target_label": "CSNK2A1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Binding constant for full-length CSNK2A1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "23604",
"properties": {
"id": "midostaurin targets DAPK2",
"source_label": "midostaurin",
"target_label": "DAPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Binding constant for full-length DAPK2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "1859",
"properties": {
"id": "midostaurin targets DYRK1A",
"source_label": "midostaurin",
"target_label": "DYRK1A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Binding affinity to DYRK1A",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "9149",
"properties": {
"id": "midostaurin targets DYRK1B",
"source_label": "midostaurin",
"target_label": "DYRK1B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Binding constant for full-length DYRK1B",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "midostaurin targets EGFR",
"source_label": "midostaurin",
"target_label": "EGFR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.06",
"act_comment": "Binding constant for EGFR(L858R,T790M) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "440275",
"properties": {
"id": "midostaurin targets EIF2AK4",
"source_label": "midostaurin",
"target_label": "EIF2AK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.41",
"act_comment": "Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "2268",
"properties": {
"id": "midostaurin targets FGR",
"source_label": "midostaurin",
"target_label": "FGR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Binding constant for FGR kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "2321",
"properties": {
"id": "midostaurin targets FLT1",
"source_label": "midostaurin",
"target_label": "FLT1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Binding constant for FLT1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "midostaurin targets FLT3",
"source_label": "midostaurin",
"target_label": "FLT3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "2324",
"properties": {
"id": "midostaurin targets FLT4",
"source_label": "midostaurin",
"target_label": "FLT4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Binding constant for FLT4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "2580",
"properties": {
"id": "midostaurin targets GAK",
"source_label": "midostaurin",
"target_label": "GAK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Binding constant for GAK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "6011",
"properties": {
"id": "midostaurin targets GRK1",
"source_label": "midostaurin",
"target_label": "GRK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.07",
"act_comment": "Binding affinity to GRK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "2868",
"properties": {
"id": "midostaurin targets GRK4",
"source_label": "midostaurin",
"target_label": "GRK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Binding affinity to GRK4",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "131890",
"properties": {
"id": "midostaurin targets GRK7",
"source_label": "midostaurin",
"target_label": "GRK7",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.32",
"act_comment": "Binding affinity to GRK7",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "3055",
"properties": {
"id": "midostaurin targets HCK",
"source_label": "midostaurin",
"target_label": "HCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Binding constant for HCK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "147746",
"properties": {
"id": "midostaurin targets HIPK4",
"source_label": "midostaurin",
"target_label": "HIPK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "Binding affinity to HIPK4",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "30811",
"properties": {
"id": "midostaurin targets HUNK",
"source_label": "midostaurin",
"target_label": "HUNK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding affinity to HUNK",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "9641",
"properties": {
"id": "midostaurin targets IKBKE",
"source_label": "midostaurin",
"target_label": "IKBKE",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "Binding constant for full-length IKK-epsilon",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "11213",
"properties": {
"id": "midostaurin targets IRAK3",
"source_label": "midostaurin",
"target_label": "IRAK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.75",
"act_comment": "Binding constant for IRAK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "3716",
"properties": {
"id": "midostaurin targets JAK1",
"source_label": "midostaurin",
"target_label": "JAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Binding affinity to JH1 catalytic domain JAK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "3717",
"properties": {
"id": "midostaurin targets JAK2",
"source_label": "midostaurin",
"target_label": "JAK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.03",
"act_comment": "Binding constant for JAK2(Kin.Dom.2/JH1 - catalytic) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "3718",
"properties": {
"id": "midostaurin targets JAK3",
"source_label": "midostaurin",
"target_label": "JAK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Binding constant for JAK3(Kin.Dom.2/JH1 - catalytic) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "midostaurin targets KDR",
"source_label": "midostaurin",
"target_label": "KDR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Inhibition of recombinant GST-tagged VEGFR2 kinase domain (V789 to V1356) (unknown origin) expressed in insect Sf9 cells using polyGlu4:Tyr peptide as substrate after 120 mins by Kinase-Glo assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "midostaurin targets KIT",
"source_label": "midostaurin",
"target_label": "KIT",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.11",
"act_comment": "Binding constant for KIT(D816V) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "midostaurin targets LCK",
"source_label": "midostaurin",
"target_label": "LCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Binding constant for LCK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "120892",
"properties": {
"id": "midostaurin targets LRRK2",
"source_label": "midostaurin",
"target_label": "LRRK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.75",
"act_comment": "Binding constant for LRRK2(G2019S) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "4294",
"properties": {
"id": "midostaurin targets MAP3K10",
"source_label": "midostaurin",
"target_label": "MAP3K10",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Binding constant for MLK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "4296",
"properties": {
"id": "midostaurin targets MAP3K11",
"source_label": "midostaurin",
"target_label": "MAP3K11",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "Binding constant for MLK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "80122",
"properties": {
"id": "midostaurin targets MAP3K19",
"source_label": "midostaurin",
"target_label": "MAP3K19",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.82",
"act_comment": "Binding affinity to YSK4",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "10746",
"properties": {
"id": "midostaurin targets MAP3K2",
"source_label": "midostaurin",
"target_label": "MAP3K2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Binding affinity to MAP3K2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "4215",
"properties": {
"id": "midostaurin targets MAP3K3",
"source_label": "midostaurin",
"target_label": "MAP3K3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Binding affinity to MAP3K3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "6885",
"properties": {
"id": "midostaurin targets MAP3K7",
"source_label": "midostaurin",
"target_label": "MAP3K7",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Binding affinity to TAK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "4293",
"properties": {
"id": "midostaurin targets MAP3K9",
"source_label": "midostaurin",
"target_label": "MAP3K9",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.82",
"act_comment": "Binding constant for MLK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "8491",
"properties": {
"id": "midostaurin targets MAP4K3",
"source_label": "midostaurin",
"target_label": "MAP4K3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Binding constant for MAP4K3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "9448",
"properties": {
"id": "midostaurin targets MAP4K4",
"source_label": "midostaurin",
"target_label": "MAP4K4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Binding constant for MAP4K4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "4139",
"properties": {
"id": "midostaurin targets MARK1",
"source_label": "midostaurin",
"target_label": "MARK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Binding constant for MARK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "2011",
"properties": {
"id": "midostaurin targets MARK2",
"source_label": "midostaurin",
"target_label": "MARK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Binding constant for MARK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "4140",
"properties": {
"id": "midostaurin targets MARK3",
"source_label": "midostaurin",
"target_label": "MARK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.68",
"act_comment": "Binding constant for full-length MARK3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "57787",
"properties": {
"id": "midostaurin targets MARK4",
"source_label": "midostaurin",
"target_label": "MARK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.43",
"act_comment": "Binding constant for MARK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "22983",
"properties": {
"id": "midostaurin targets MAST1",
"source_label": "midostaurin",
"target_label": "MAST1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Binding constant for MAST1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "9833",
"properties": {
"id": "midostaurin targets MELK",
"source_label": "midostaurin",
"target_label": "MELK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Binding constant for full-length MELK",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "4233",
"properties": {
"id": "midostaurin targets MET",
"source_label": "midostaurin",
"target_label": "MET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "Binding constant for MET(Y1235D) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "50488",
"properties": {
"id": "midostaurin targets MINK1",
"source_label": "midostaurin",
"target_label": "MINK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Binding affinity to MINK",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "2872",
"properties": {
"id": "midostaurin targets MKNK2",
"source_label": "midostaurin",
"target_label": "MKNK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "Binding constant for MKNK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "4638",
"properties": {
"id": "midostaurin targets MYLK",
"source_label": "midostaurin",
"target_label": "MYLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Binding affinity to MYLK",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "340156",
"properties": {
"id": "midostaurin targets MYLK4",
"source_label": "midostaurin",
"target_label": "MYLK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Binding constant for SgK085 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "4914",
"properties": {
"id": "midostaurin targets NTRK1",
"source_label": "midostaurin",
"target_label": "NTRK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.42",
"act_comment": "Binding constant for TRKA kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "4915",
"properties": {
"id": "midostaurin targets NTRK2",
"source_label": "midostaurin",
"target_label": "NTRK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "Binding constant for TRKB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "9891",
"properties": {
"id": "midostaurin targets NUAK1",
"source_label": "midostaurin",
"target_label": "NUAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.39",
"act_comment": "Binding constant for ARK5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "81788",
"properties": {
"id": "midostaurin targets NUAK2",
"source_label": "midostaurin",
"target_label": "NUAK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "Binding constant for SNARK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5063",
"properties": {
"id": "midostaurin targets PAK3",
"source_label": "midostaurin",
"target_label": "PAK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.75",
"act_comment": "Binding constant for full-length PAK3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5156",
"properties": {
"id": "midostaurin targets PDGFRA",
"source_label": "midostaurin",
"target_label": "PDGFRA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.75",
"act_comment": "Binding affinity to PDGFRA",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "midostaurin targets PDGFRB",
"source_label": "midostaurin",
"target_label": "PDGFRB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Binding constant for PDGFRB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5170",
"properties": {
"id": "midostaurin targets PDPK1",
"source_label": "midostaurin",
"target_label": "PDPK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Binding affinity to PDPK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5260",
"properties": {
"id": "midostaurin targets PHKG1",
"source_label": "midostaurin",
"target_label": "PHKG1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Binding affinity to PHKG1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5261",
"properties": {
"id": "midostaurin targets PHKG2",
"source_label": "midostaurin",
"target_label": "PHKG2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Binding affinity to PHKG2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5288",
"properties": {
"id": "midostaurin targets PIK3C2G",
"source_label": "midostaurin",
"target_label": "PIK3C2G",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Binding affinity to PIK3C2G",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5292",
"properties": {
"id": "midostaurin targets PIM1",
"source_label": "midostaurin",
"target_label": "PIM1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "Binding constant for PIM1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "415116",
"properties": {
"id": "midostaurin targets PIM3",
"source_label": "midostaurin",
"target_label": "PIM3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "Binding constant for PIM3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "8396",
"properties": {
"id": "midostaurin targets PIP4K2B",
"source_label": "midostaurin",
"target_label": "PIP4K2B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Binding constant for full-length PIP5K2B",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "8394",
"properties": {
"id": "midostaurin targets PIP5K1A",
"source_label": "midostaurin",
"target_label": "PIP5K1A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "Binding constant for full-length PIP5K1A",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5585",
"properties": {
"id": "midostaurin targets PKN1",
"source_label": "midostaurin",
"target_label": "PKN1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.03",
"act_comment": "Binding constant for PKN1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5586",
"properties": {
"id": "midostaurin targets PKN2",
"source_label": "midostaurin",
"target_label": "PKN2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.82",
"act_comment": "Binding constant for PKN2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "10733",
"properties": {
"id": "midostaurin targets PLK4",
"source_label": "midostaurin",
"target_label": "PLK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.18",
"act_comment": "Binding constant for PLK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5562",
"properties": {
"id": "midostaurin targets PRKAA1",
"source_label": "midostaurin",
"target_label": "PRKAA1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.75",
"act_comment": "Binding constant for AMPK-alpha1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5563",
"properties": {
"id": "midostaurin targets PRKAA2",
"source_label": "midostaurin",
"target_label": "PRKAA2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.34",
"act_comment": "Binding constant for AMPK-alpha2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5566",
"properties": {
"id": "midostaurin targets PRKACA",
"source_label": "midostaurin",
"target_label": "PRKACA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Binding constant for PKAC-alpha kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5567",
"properties": {
"id": "midostaurin targets PRKACB",
"source_label": "midostaurin",
"target_label": "PRKACB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding constant for full-length PKAC-beta",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5578",
"properties": {
"id": "midostaurin targets PRKCA",
"source_label": "midostaurin",
"target_label": "PRKCA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.14",
"act_comment": "Binding affinity to PKAC-alpha",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5580",
"properties": {
"id": "midostaurin targets PRKCD",
"source_label": "midostaurin",
"target_label": "PRKCD",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "Binding constant for PRKCD kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5581",
"properties": {
"id": "midostaurin targets PRKCE",
"source_label": "midostaurin",
"target_label": "PRKCE",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.27",
"act_comment": "Binding constant for PRKCE kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5583",
"properties": {
"id": "midostaurin targets PRKCH",
"source_label": "midostaurin",
"target_label": "PRKCH",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Binding constant for PRKCH kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5588",
"properties": {
"id": "midostaurin targets PRKCQ",
"source_label": "midostaurin",
"target_label": "PRKCQ",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "Binding constant for PRKCQ kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5592",
"properties": {
"id": "midostaurin targets PRKG1",
"source_label": "midostaurin",
"target_label": "PRKG1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Binding constant for PRKG1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5593",
"properties": {
"id": "midostaurin targets PRKG2",
"source_label": "midostaurin",
"target_label": "PRKG2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.13",
"act_comment": "Binding constant for PRKG2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5613",
"properties": {
"id": "midostaurin targets PRKX",
"source_label": "midostaurin",
"target_label": "PRKX",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "Binding constant for full-length PRKX",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "9128",
"properties": {
"id": "midostaurin targets PRPF4",
"source_label": "midostaurin",
"target_label": "PRPF4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.26",
"act_comment": "Binding affinity to PRP4",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "8899",
"properties": {
"id": "midostaurin targets PRPF4B",
"source_label": "midostaurin",
"target_label": "PRPF4B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.26",
"act_comment": "Binding constant for PRP4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "2185",
"properties": {
"id": "midostaurin targets PTK2B",
"source_label": "midostaurin",
"target_label": "PTK2B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.18",
"act_comment": "Binding constant for full-length PTK2B",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "midostaurin targets RET",
"source_label": "midostaurin",
"target_label": "RET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Binding constant for RET(V804M) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "55781",
"properties": {
"id": "midostaurin targets RIOK2",
"source_label": "midostaurin",
"target_label": "RIOK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.01",
"act_comment": "Binding affinity to RIOK2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "8780",
"properties": {
"id": "midostaurin targets RIOK3",
"source_label": "midostaurin",
"target_label": "RIOK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Binding constant for full-length RIOK3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "6098",
"properties": {
"id": "midostaurin targets ROS1",
"source_label": "midostaurin",
"target_label": "ROS1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "Binding constant for ROS1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "6195",
"properties": {
"id": "midostaurin targets RPS6KA1",
"source_label": "midostaurin",
"target_label": "RPS6KA1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "Binding affinity to RPS6KA4(Kin.Dom.1-N-terminal)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "6196",
"properties": {
"id": "midostaurin targets RPS6KA2",
"source_label": "midostaurin",
"target_label": "RPS6KA2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding affinity to RPS6KA5(Kin.Dom.1-N-terminal)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "6197",
"properties": {
"id": "midostaurin targets RPS6KA3",
"source_label": "midostaurin",
"target_label": "RPS6KA3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "Binding constant for RPS6KA3(Kin.Dom.1 - N-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "8986",
"properties": {
"id": "midostaurin targets RPS6KA4",
"source_label": "midostaurin",
"target_label": "RPS6KA4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.59",
"act_comment": "Binding constant for RPS6KA4(Kin.Dom.1 - C-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "9252",
"properties": {
"id": "midostaurin targets RPS6KA5",
"source_label": "midostaurin",
"target_label": "RPS6KA5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding constant for RPS6KA5(Kin.Dom.1 - C-terminal) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "150094",
"properties": {
"id": "midostaurin targets SIK1",
"source_label": "midostaurin",
"target_label": "SIK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "Binding constant for SNF1LK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "23235",
"properties": {
"id": "midostaurin targets SIK2",
"source_label": "midostaurin",
"target_label": "SIK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.25",
"act_comment": "Binding constant for full-length SNF1LK2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "23387",
"properties": {
"id": "midostaurin targets SIK3",
"source_label": "midostaurin",
"target_label": "SIK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.01",
"act_comment": "Binding affinity to QSK",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "9748",
"properties": {
"id": "midostaurin targets SLK",
"source_label": "midostaurin",
"target_label": "SLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Binding constant for SLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "6732",
"properties": {
"id": "midostaurin targets SRPK1",
"source_label": "midostaurin",
"target_label": "SRPK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.38",
"act_comment": "Binding constant for full-length SRPK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "6733",
"properties": {
"id": "midostaurin targets SRPK2",
"source_label": "midostaurin",
"target_label": "SRPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Binding constant for full-length SRPK2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "26576",
"properties": {
"id": "midostaurin targets SRPK3",
"source_label": "midostaurin",
"target_label": "SRPK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "Binding affinity to SRPK3",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "6793",
"properties": {
"id": "midostaurin targets STK10",
"source_label": "midostaurin",
"target_label": "STK10",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.23",
"act_comment": "Binding constant for LOK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "6794",
"properties": {
"id": "midostaurin targets STK11",
"source_label": "midostaurin",
"target_label": "STK11",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Binding constant for full-length LKB1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "8576",
"properties": {
"id": "midostaurin targets STK16",
"source_label": "midostaurin",
"target_label": "STK16",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Binding constant for STK16 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "6788",
"properties": {
"id": "midostaurin targets STK3",
"source_label": "midostaurin",
"target_label": "STK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "Binding affinity to MST2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "65975",
"properties": {
"id": "midostaurin targets STK33",
"source_label": "midostaurin",
"target_label": "STK33",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Binding constant for STK33 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "6789",
"properties": {
"id": "midostaurin targets STK4",
"source_label": "midostaurin",
"target_label": "STK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "Binding affinity to MST1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "6850",
"properties": {
"id": "midostaurin targets SYK",
"source_label": "midostaurin",
"target_label": "SYK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.06",
"act_comment": "Binding constant for SYK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "29110",
"properties": {
"id": "midostaurin targets TBK1",
"source_label": "midostaurin",
"target_label": "TBK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.03",
"act_comment": "Binding affinity to TBK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "8711",
"properties": {
"id": "midostaurin targets TNK1",
"source_label": "midostaurin",
"target_label": "TNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.08",
"act_comment": "Binding constant for full-length TNK1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "10188",
"properties": {
"id": "midostaurin targets TNK2",
"source_label": "midostaurin",
"target_label": "TNK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Binding constant for TNK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "80351",
"properties": {
"id": "midostaurin targets TNKS2",
"source_label": "midostaurin",
"target_label": "TNKS2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Binding affinity to TNK2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "7272",
"properties": {
"id": "midostaurin targets TTK",
"source_label": "midostaurin",
"target_label": "TTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Binding constant for TTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "7297",
"properties": {
"id": "midostaurin targets TYK2",
"source_label": "midostaurin",
"target_label": "TYK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Binding constant for TYK2(Kin.Dom.2/JH1 - catalytic) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "7301",
"properties": {
"id": "midostaurin targets TYRO3",
"source_label": "midostaurin",
"target_label": "TYRO3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.06",
"act_comment": "Inhibition of SKY (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9829523",
"relation": "IDG (Drug Target)",
"target": "7525",
"properties": {
"id": "midostaurin targets YES1",
"source_label": "midostaurin",
"target_label": "YES1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "Binding constant for YES kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:76943386",
"relation": "IDG (Drug Target)",
"target": "5745",
"properties": {
"id": "abaloparatide targets PTH1R",
"source_label": "abaloparatide",
"target_label": "PTH1R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:68165256",
"relation": "IDG (Drug Target)",
"target": "238",
"properties": {
"id": "brigatinib targets ALK",
"source_label": "brigatinib",
"target_label": "ALK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.222",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:68165256",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "brigatinib targets EGFR",
"source_label": "brigatinib",
"target_label": "EGFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.174",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:68165256",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "brigatinib targets FLT3",
"source_label": "brigatinib",
"target_label": "FLT3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.678",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:68165256",
"relation": "IDG (Drug Target)",
"target": "3480",
"properties": {
"id": "brigatinib targets IGF1R",
"source_label": "brigatinib",
"target_label": "IGF1R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.137",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:68165256",
"relation": "IDG (Drug Target)",
"target": "3643",
"properties": {
"id": "brigatinib targets INSR",
"source_label": "brigatinib",
"target_label": "INSR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.796",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:68165256",
"relation": "IDG (Drug Target)",
"target": "6098",
"properties": {
"id": "brigatinib targets ROS1",
"source_label": "brigatinib",
"target_label": "ROS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.721",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:25022354",
"relation": "IDG (Drug Target)",
"target": "1803",
"properties": {
"id": "evogliptin targets DPP4",
"source_label": "evogliptin",
"target_label": "DPP4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.046",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9841854",
"relation": "IDG (Drug Target)",
"target": "5742",
"properties": {
"id": "polmacoxib targets PTGS1",
"source_label": "polmacoxib",
"target_label": "PTGS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.081",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9841854",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "polmacoxib targets PTGS2",
"source_label": "polmacoxib",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.081",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:10275777",
"relation": "IDG (Drug Target)",
"target": "2159",
"properties": {
"id": "betrixaban targets F10",
"source_label": "betrixaban",
"target_label": "F10",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.824",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11526038",
"relation": "IDG (Drug Target)",
"target": "5465",
"properties": {
"id": "pemafibrate targets PPARA",
"source_label": "pemafibrate",
"target_label": "PPARA",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11682175",
"relation": "IDG (Drug Target)",
"target": "5743",
"properties": {
"id": "imrecoxib targets PTGS2",
"source_label": "imrecoxib",
"target_label": "PTGS2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.824",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:89683805",
"relation": "IDG (Drug Target)",
"target": "3418",
"properties": {
"id": "enasidenib targets IDH2",
"source_label": "enasidenib",
"target_label": "IDH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "inhibition of 2HG production by the IDH2(R140Q) homodimer",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "203054",
"properties": {
"id": "neratinib targets ADCK5",
"source_label": "neratinib",
"target_label": "ADCK5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "558",
"properties": {
"id": "neratinib targets AXL",
"source_label": "neratinib",
"target_label": "AXL",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Binding constant for AXL kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "640",
"properties": {
"id": "neratinib targets BLK",
"source_label": "neratinib",
"target_label": "BLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.07",
"act_comment": "Binding constant for BLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "695",
"properties": {
"id": "neratinib targets BTK",
"source_label": "neratinib",
"target_label": "BTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "Binding constant for BTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "11200",
"properties": {
"id": "neratinib targets CHEK2",
"source_label": "neratinib",
"target_label": "CHEK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "Binding constant for CHEK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "1436",
"properties": {
"id": "neratinib targets CSF1R",
"source_label": "neratinib",
"target_label": "CSF1R",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Binding constant for CSF1R kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "1445",
"properties": {
"id": "neratinib targets CSK",
"source_label": "neratinib",
"target_label": "CSK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "Binding constant for CSK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "1454",
"properties": {
"id": "neratinib targets CSNK1E",
"source_label": "neratinib",
"target_label": "CSNK1E",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Binding constant for CSNK1E kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "neratinib targets EGFR",
"source_label": "neratinib",
"target_label": "EGFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.036",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "440275",
"properties": {
"id": "neratinib targets EIF2AK4",
"source_label": "neratinib",
"target_label": "EIF2AK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.02",
"act_comment": "Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "2064",
"properties": {
"id": "neratinib targets ERBB2",
"source_label": "neratinib",
"target_label": "ERBB2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.229",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "2065",
"properties": {
"id": "neratinib targets ERBB3",
"source_label": "neratinib",
"target_label": "ERBB3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.11",
"act_comment": "Binding constant for ERBB3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "2066",
"properties": {
"id": "neratinib targets ERBB4",
"source_label": "neratinib",
"target_label": "ERBB4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.62",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "2241",
"properties": {
"id": "neratinib targets FER",
"source_label": "neratinib",
"target_label": "FER",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "Binding constant for FER kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "2242",
"properties": {
"id": "neratinib targets FES",
"source_label": "neratinib",
"target_label": "FES",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.23",
"act_comment": "Binding constant for FES kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "2580",
"properties": {
"id": "neratinib targets GAK",
"source_label": "neratinib",
"target_label": "GAK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Binding constant for GAK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "3055",
"properties": {
"id": "neratinib targets HCK",
"source_label": "neratinib",
"target_label": "HCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.31",
"act_comment": "Binding constant for HCK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "neratinib targets KDR",
"source_label": "neratinib",
"target_label": "KDR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "Inhibition of human VEGFR2 in presence of 1 uM ATP",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "neratinib targets LCK",
"source_label": "neratinib",
"target_label": "LCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Binding constant for LCK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "4067",
"properties": {
"id": "neratinib targets LYN",
"source_label": "neratinib",
"target_label": "LYN",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Binding constant for LYN kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "5604",
"properties": {
"id": "neratinib targets MAP2K1",
"source_label": "neratinib",
"target_label": "MAP2K1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "Binding constant for MEK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "5605",
"properties": {
"id": "neratinib targets MAP2K2",
"source_label": "neratinib",
"target_label": "MAP2K2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.59",
"act_comment": "Binding constant for MEK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "5607",
"properties": {
"id": "neratinib targets MAP2K5",
"source_label": "neratinib",
"target_label": "MAP2K5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.2",
"act_comment": "Binding constant for MEK5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "5609",
"properties": {
"id": "neratinib targets MAP2K7",
"source_label": "neratinib",
"target_label": "MAP2K7",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Binding constant for MKK7 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "7786",
"properties": {
"id": "neratinib targets MAP3K12",
"source_label": "neratinib",
"target_label": "MAP3K12",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.43",
"act_comment": "Binding constant for DLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "9175",
"properties": {
"id": "neratinib targets MAP3K13",
"source_label": "neratinib",
"target_label": "MAP3K13",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "Binding constant for LZK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "80122",
"properties": {
"id": "neratinib targets MAP3K19",
"source_label": "neratinib",
"target_label": "MAP3K19",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "Binding constant for YSK4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "10746",
"properties": {
"id": "neratinib targets MAP3K2",
"source_label": "neratinib",
"target_label": "MAP3K2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Binding constant for MAP3K2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "4215",
"properties": {
"id": "neratinib targets MAP3K3",
"source_label": "neratinib",
"target_label": "MAP3K3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.89",
"act_comment": "Binding constant for MAP3K3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "4216",
"properties": {
"id": "neratinib targets MAP3K4",
"source_label": "neratinib",
"target_label": "MAP3K4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.41",
"act_comment": "Binding constant for MAP3K4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "11184",
"properties": {
"id": "neratinib targets MAP4K1",
"source_label": "neratinib",
"target_label": "MAP4K1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.03",
"act_comment": "Binding constant for HPK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "5871",
"properties": {
"id": "neratinib targets MAP4K2",
"source_label": "neratinib",
"target_label": "MAP4K2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Binding constant for MAP4K2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "8491",
"properties": {
"id": "neratinib targets MAP4K3",
"source_label": "neratinib",
"target_label": "MAP4K3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.11",
"act_comment": "Binding constant for MAP4K3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "9448",
"properties": {
"id": "neratinib targets MAP4K4",
"source_label": "neratinib",
"target_label": "MAP4K4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.48",
"act_comment": "Binding constant for MAP4K4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "11183",
"properties": {
"id": "neratinib targets MAP4K5",
"source_label": "neratinib",
"target_label": "MAP4K5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.19",
"act_comment": "Binding constant for MAP4K5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "10461",
"properties": {
"id": "neratinib targets MERTK",
"source_label": "neratinib",
"target_label": "MERTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.4",
"act_comment": "Binding constant for MERTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "50488",
"properties": {
"id": "neratinib targets MINK1",
"source_label": "neratinib",
"target_label": "MINK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.54",
"act_comment": "Binding constant for MINK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "4751",
"properties": {
"id": "neratinib targets NEK2",
"source_label": "neratinib",
"target_label": "NEK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Binding constant for NEK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "81788",
"properties": {
"id": "neratinib targets NUAK2",
"source_label": "neratinib",
"target_label": "NUAK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Binding constant for SNARK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "5058",
"properties": {
"id": "neratinib targets PAK1",
"source_label": "neratinib",
"target_label": "PAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Binding constant for PAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "5062",
"properties": {
"id": "neratinib targets PAK2",
"source_label": "neratinib",
"target_label": "PAK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "Binding constant for PAK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "5587",
"properties": {
"id": "neratinib targets PRKD1",
"source_label": "neratinib",
"target_label": "PRKD1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Binding constant for PRKD1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "150094",
"properties": {
"id": "neratinib targets SIK1",
"source_label": "neratinib",
"target_label": "SIK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Binding constant for SIK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "9748",
"properties": {
"id": "neratinib targets SLK",
"source_label": "neratinib",
"target_label": "SLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.18",
"act_comment": "Binding constant for SLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "6793",
"properties": {
"id": "neratinib targets STK10",
"source_label": "neratinib",
"target_label": "STK10",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Binding constant for LOK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "9263",
"properties": {
"id": "neratinib targets STK17A",
"source_label": "neratinib",
"target_label": "STK17A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "Binding constant for DRAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "8428",
"properties": {
"id": "neratinib targets STK24",
"source_label": "neratinib",
"target_label": "STK24",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.19",
"act_comment": "Binding constant for MST3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "10494",
"properties": {
"id": "neratinib targets STK25",
"source_label": "neratinib",
"target_label": "STK25",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Binding constant for YSK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "51765",
"properties": {
"id": "neratinib targets STK26",
"source_label": "neratinib",
"target_label": "STK26",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.13",
"act_comment": "Binding constant for MST4 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "6788",
"properties": {
"id": "neratinib targets STK3",
"source_label": "neratinib",
"target_label": "STK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.24",
"act_comment": "Binding constant for MST2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "65975",
"properties": {
"id": "neratinib targets STK33",
"source_label": "neratinib",
"target_label": "STK33",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "Binding constant for STK33 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "6789",
"properties": {
"id": "neratinib targets STK4",
"source_label": "neratinib",
"target_label": "STK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Binding constant for MST1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "7075",
"properties": {
"id": "neratinib targets TIE1",
"source_label": "neratinib",
"target_label": "TIE1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "Binding constant for TIE1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "23043",
"properties": {
"id": "neratinib targets TNIK",
"source_label": "neratinib",
"target_label": "TNIK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Binding constant for TNIK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "10188",
"properties": {
"id": "neratinib targets TNK2",
"source_label": "neratinib",
"target_label": "TNK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.17",
"act_comment": "Binding constant for TNK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9915743",
"relation": "IDG (Drug Target)",
"target": "7525",
"properties": {
"id": "neratinib targets YES1",
"source_label": "neratinib",
"target_label": "YES1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Binding constant for YES kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24989044",
"relation": "IDG (Drug Target)",
"target": "2475",
"properties": {
"id": "copanlisib targets MTOR",
"source_label": "copanlisib",
"target_label": "MTOR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.35",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:24989044",
"relation": "IDG (Drug Target)",
"target": "5290",
"properties": {
"id": "copanlisib targets PIK3CA",
"source_label": "copanlisib",
"target_label": "PIK3CA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.301",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24989044",
"relation": "IDG (Drug Target)",
"target": "5291",
"properties": {
"id": "copanlisib targets PIK3CB",
"source_label": "copanlisib",
"target_label": "PIK3CB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.432",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24989044",
"relation": "IDG (Drug Target)",
"target": "5293",
"properties": {
"id": "copanlisib targets PIK3CD",
"source_label": "copanlisib",
"target_label": "PIK3CD",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.155",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24989044",
"relation": "IDG (Drug Target)",
"target": "5294",
"properties": {
"id": "copanlisib targets PIK3CG",
"source_label": "copanlisib",
"target_label": "PIK3CG",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.194",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:61361",
"relation": "IDG (Drug Target)",
"target": "3776",
"properties": {
"id": "butylphthalide targets KCNK2",
"source_label": "butylphthalide",
"target_label": "KCNK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.222",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "tivozanib targets ABL1",
"source_label": "tivozanib",
"target_label": "ABL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.71",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "27",
"properties": {
"id": "tivozanib targets ABL2",
"source_label": "tivozanib",
"target_label": "ABL2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "613",
"properties": {
"id": "tivozanib targets BCR",
"source_label": "tivozanib",
"target_label": "BCR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "780",
"properties": {
"id": "tivozanib targets DDR1",
"source_label": "tivozanib",
"target_label": "DDR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "4921",
"properties": {
"id": "tivozanib targets DDR2",
"source_label": "tivozanib",
"target_label": "DDR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.23",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "1969",
"properties": {
"id": "tivozanib targets EPHA2",
"source_label": "tivozanib",
"target_label": "EPHA2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.83",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "2044",
"properties": {
"id": "tivozanib targets EPHA5",
"source_label": "tivozanib",
"target_label": "EPHA5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "2048",
"properties": {
"id": "tivozanib targets EPHB2",
"source_label": "tivozanib",
"target_label": "EPHB2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.76",
"act_comment": "Inhibition of recombinant EphB2 (unknown origin) by cell-free assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "2050",
"properties": {
"id": "tivozanib targets EPHB4",
"source_label": "tivozanib",
"target_label": "EPHB4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.51",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "2260",
"properties": {
"id": "tivozanib targets FGFR1",
"source_label": "tivozanib",
"target_label": "FGFR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.524",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "2321",
"properties": {
"id": "tivozanib targets FLT1",
"source_label": "tivozanib",
"target_label": "FLT1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.678",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "tivozanib targets FLT3",
"source_label": "tivozanib",
"target_label": "FLT3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.375",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "2324",
"properties": {
"id": "tivozanib targets FLT4",
"source_label": "tivozanib",
"target_label": "FLT4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.62",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "2444",
"properties": {
"id": "tivozanib targets FRK",
"source_label": "tivozanib",
"target_label": "FRK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.84",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "tivozanib targets KDR",
"source_label": "tivozanib",
"target_label": "KDR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.796",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "tivozanib targets KIT",
"source_label": "tivozanib",
"target_label": "KIT",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.788",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "5156",
"properties": {
"id": "tivozanib targets PDGFRA",
"source_label": "tivozanib",
"target_label": "PDGFRA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.65",
"act_comment": "Inhibition of recombinant PDGFRalpha (unknown origin) by cell-free assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "tivozanib targets PDGFRB",
"source_label": "tivozanib",
"target_label": "PDGFRB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.764",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "5037",
"properties": {
"id": "tivozanib targets PEBP1",
"source_label": "tivozanib",
"target_label": "PEBP1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "5753",
"properties": {
"id": "tivozanib targets PTK6",
"source_label": "tivozanib",
"target_label": "PTK6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "tivozanib targets RET",
"source_label": "tivozanib",
"target_label": "RET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9911830",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "tivozanib targets RIPK2",
"source_label": "tivozanib",
"target_label": "RIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "22848",
"properties": {
"id": "abemaciclib targets AAK1",
"source_label": "abemaciclib",
"target_label": "AAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.99",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "57143",
"properties": {
"id": "abemaciclib targets ADCK1",
"source_label": "abemaciclib",
"target_label": "ADCK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "817",
"properties": {
"id": "abemaciclib targets CAMK2D",
"source_label": "abemaciclib",
"target_label": "CAMK2D",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "818",
"properties": {
"id": "abemaciclib targets CAMK2G",
"source_label": "abemaciclib",
"target_label": "CAMK2G",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.75",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "5127",
"properties": {
"id": "abemaciclib targets CDK16",
"source_label": "abemaciclib",
"target_label": "CDK16",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "1019",
"properties": {
"id": "abemaciclib targets CDK4",
"source_label": "abemaciclib",
"target_label": "CDK4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.222",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "1021",
"properties": {
"id": "abemaciclib targets CDK6",
"source_label": "abemaciclib",
"target_label": "CDK6",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.62",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "1022",
"properties": {
"id": "abemaciclib targets CDK7",
"source_label": "abemaciclib",
"target_label": "CDK7",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Inhibition of CDK7 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "1025",
"properties": {
"id": "abemaciclib targets CDK9",
"source_label": "abemaciclib",
"target_label": "CDK9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.24",
"act_comment": "Inhibition of CDK9 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "11113",
"properties": {
"id": "abemaciclib targets CIT",
"source_label": "abemaciclib",
"target_label": "CIT",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "1195",
"properties": {
"id": "abemaciclib targets CLK1",
"source_label": "abemaciclib",
"target_label": "CLK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.15",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "57396",
"properties": {
"id": "abemaciclib targets CLK4",
"source_label": "abemaciclib",
"target_label": "CLK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "1459",
"properties": {
"id": "abemaciclib targets CSNK2A2",
"source_label": "abemaciclib",
"target_label": "CSNK2A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "1859",
"properties": {
"id": "abemaciclib targets DYRK1A",
"source_label": "abemaciclib",
"target_label": "DYRK1A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.69",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "2931",
"properties": {
"id": "abemaciclib targets GSK3A",
"source_label": "abemaciclib",
"target_label": "GSK3A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "2932",
"properties": {
"id": "abemaciclib targets GSK3B",
"source_label": "abemaciclib",
"target_label": "GSK3B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "22858",
"properties": {
"id": "abemaciclib targets CILK1",
"source_label": "abemaciclib",
"target_label": "CILK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.28",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "3654",
"properties": {
"id": "abemaciclib targets IRAK1",
"source_label": "abemaciclib",
"target_label": "IRAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "5292",
"properties": {
"id": "abemaciclib targets PIM1",
"source_label": "abemaciclib",
"target_label": "PIM1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.15",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "5578",
"properties": {
"id": "abemaciclib targets PRKCA",
"source_label": "abemaciclib",
"target_label": "PRKCA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.28",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "5580",
"properties": {
"id": "abemaciclib targets PRKCD",
"source_label": "abemaciclib",
"target_label": "PRKCD",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "8576",
"properties": {
"id": "abemaciclib targets STK16",
"source_label": "abemaciclib",
"target_label": "STK16",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:46220502",
"relation": "IDG (Drug Target)",
"target": "57551",
"properties": {
"id": "abemaciclib targets TAOK1",
"source_label": "abemaciclib",
"target_label": "TAOK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.97",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71226662",
"relation": "IDG (Drug Target)",
"target": "660",
"properties": {
"id": "acalabrutinib targets BMX",
"source_label": "acalabrutinib",
"target_label": "BMX",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.337",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71226662",
"relation": "IDG (Drug Target)",
"target": "695",
"properties": {
"id": "acalabrutinib targets BTK",
"source_label": "acalabrutinib",
"target_label": "BTK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.292",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71226662",
"relation": "IDG (Drug Target)",
"target": "2064",
"properties": {
"id": "acalabrutinib targets ERBB2",
"source_label": "acalabrutinib",
"target_label": "ERBB2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.13",
"act_comment": "Binding affinity to DNA-tagged recombinant ERBB2 (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71226662",
"relation": "IDG (Drug Target)",
"target": "2066",
"properties": {
"id": "acalabrutinib targets ERBB4",
"source_label": "acalabrutinib",
"target_label": "ERBB4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71226662",
"relation": "IDG (Drug Target)",
"target": "4067",
"properties": {
"id": "acalabrutinib targets LYN",
"source_label": "acalabrutinib",
"target_label": "LYN",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:71226662",
"relation": "IDG (Drug Target)",
"target": "7006",
"properties": {
"id": "acalabrutinib targets TEC",
"source_label": "acalabrutinib",
"target_label": "TEC",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.032",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71226662",
"relation": "IDG (Drug Target)",
"target": "7294",
"properties": {
"id": "acalabrutinib targets TXK",
"source_label": "acalabrutinib",
"target_label": "TXK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.434",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:164512664",
"relation": "IDG (Drug Target)",
"target": "2740",
"properties": {
"id": "semaglutide targets GLP1R",
"source_label": "semaglutide",
"target_label": "GLP1R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.42",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:66599893",
"relation": "IDG (Drug Target)",
"target": "6093",
"properties": {
"id": "netarsudil targets ROCK1",
"source_label": "netarsudil",
"target_label": "ROCK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.49",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:66599893",
"relation": "IDG (Drug Target)",
"target": "9475",
"properties": {
"id": "netarsudil targets ROCK2",
"source_label": "netarsudil",
"target_label": "ROCK2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.377",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44814423",
"relation": "IDG (Drug Target)",
"target": "6524",
"properties": {
"id": "ertugliflozin targets SLC5A2",
"source_label": "ertugliflozin",
"target_label": "SLC5A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.057",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44814423",
"relation": "IDG (Drug Target)",
"target": "6527",
"properties": {
"id": "ertugliflozin targets SLC5A4",
"source_label": "ertugliflozin",
"target_label": "SLC5A4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.06",
"act_comment": "Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hr",
"act_source": "CHEMBL"
}
},
{
"source": "CID:134612761",
"relation": "IDG (Drug Target)",
"target": "2693",
"properties": {
"id": "macimorelin targets GHSR",
"source_label": "macimorelin",
"target_label": "GHSR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.81",
"act_comment": "In a radioligand displacement assay using 125I-labeled ghrelin as the probe, and human pituitary gland samples.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:172198",
"relation": "IDG (Drug Target)",
"target": "185",
"properties": {
"id": "angiotensin II targets AGTR1",
"source_label": "angiotensin II",
"target_label": "AGTR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:172198",
"relation": "IDG (Drug Target)",
"target": "186",
"properties": {
"id": "angiotensin II targets AGTR2",
"source_label": "angiotensin II",
"target_label": "AGTR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "10.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:46199646",
"relation": "IDG (Drug Target)",
"target": "1080",
"properties": {
"id": "tezacaftor targets CFTR",
"source_label": "tezacaftor",
"target_label": "CFTR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Correction activity at CFTR F508 deletion mutant (unknown origin) expressed in mouse NIH/3T3 cells assessed as increase in cAMP/genistein-dependent current amplitude incubated for 10 mins at 37 degC by patch clamp method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9939892",
"relation": "IDG (Drug Target)",
"target": "6555",
"properties": {
"id": "elobixibat targets SLC10A2",
"source_label": "elobixibat",
"target_label": "SLC10A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.276",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24872560",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "apalutamide targets AR",
"source_label": "apalutamide",
"target_label": "AR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.796",
"act_comment": "equilibrium-binding affinity of ARN-509 for AR measured in competition with 16b-[18F]fluoro-5a-DHT",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "22848",
"properties": {
"id": "fostamatinib targets AAK1",
"source_label": "fostamatinib",
"target_label": "AAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "Binding constant for AAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "fostamatinib targets ABL1",
"source_label": "fostamatinib",
"target_label": "ABL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Binding constant for ABL1(H396P)-non phosphorylated kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "27",
"properties": {
"id": "fostamatinib targets ABL2",
"source_label": "fostamatinib",
"target_label": "ABL2",
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}
},
{
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}
},
{
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}
},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
"source": "CID:11213558",
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},
{
"source": "CID:11213558",
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},
{
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}
},
{
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}
},
{
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}
},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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"relation": "IDG (Drug Target)",
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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}
},
{
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},
{
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"relation": "IDG (Drug Target)",
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},
{
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},
{
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"relation": "IDG (Drug Target)",
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},
{
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},
{
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},
{
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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"properties": {
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},
{
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},
{
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},
{
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{
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{
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{
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{
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{
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{
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{
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{
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},
{
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},
{
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},
{
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{
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{
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{
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},
{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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},
{
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},
{
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{
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{
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{
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},
{
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{
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{
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{
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},
{
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},
{
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},
{
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},
{
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},
{
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}
},
{
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},
{
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},
{
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"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
"source": "CID:11213558",
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}
},
{
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}
},
{
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}
},
{
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}
},
{
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}
},
{
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
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}
},
{
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}
},
{
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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}
},
{
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"relation": "IDG (Drug Target)",
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},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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},
{
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
"target": "5566",
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}
},
{
"source": "CID:11213558",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "2185",
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"act_relation": "=",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "5753",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "5894",
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}
},
{
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"relation": "IDG (Drug Target)",
"target": "5979",
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}
},
{
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"relation": "IDG (Drug Target)",
"target": "83732",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "8780",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "fostamatinib targets RIPK2",
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"act_relation": "=",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "54101",
"properties": {
"id": "fostamatinib targets RIPK4",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "6093",
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"id": "fostamatinib targets ROCK1",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "9475",
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"id": "fostamatinib targets ROCK2",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "6098",
"properties": {
"id": "fostamatinib targets ROS1",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "6195",
"properties": {
"id": "fostamatinib targets RPS6KA1",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "8986",
"properties": {
"id": "fostamatinib targets RPS6KA4",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "9252",
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"id": "fostamatinib targets RPS6KA5",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "388228",
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"id": "fostamatinib targets SBK1",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "100130827",
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"id": "fostamatinib targets SBK3",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "150094",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "23235",
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"id": "fostamatinib targets SIK2",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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"id": "fostamatinib targets SRPK1",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "8576",
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"id": "fostamatinib targets STK16",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "9263",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "65975",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "27148",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
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"target": "57551",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
"target": "7048",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "9874",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "11011",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "8711",
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"id": "fostamatinib targets TNK1",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
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"properties": {
"id": "fostamatinib targets TNK2",
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}
},
{
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"relation": "IDG (Drug Target)",
"target": "51086",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "83942",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "7294",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "7297",
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"id": "fostamatinib targets TYK2",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "8408",
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"id": "fostamatinib targets ULK1",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "9706",
"properties": {
"id": "fostamatinib targets ULK2",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "25989",
"properties": {
"id": "fostamatinib targets ULK3",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "7465",
"properties": {
"id": "fostamatinib targets WEE1",
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"act_relation": "=",
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}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "7525",
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"id": "fostamatinib targets YES1",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "7.46",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:11213558",
"relation": "IDG (Drug Target)",
"target": "7535",
"properties": {
"id": "fostamatinib targets ZAP70",
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"act_relation": "=",
"act_value": "7.68",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:71544787",
"relation": "IDG (Drug Target)",
"target": "6869",
"properties": {
"id": "fosnetupitant targets TACR1",
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"act_value": "9.022",
"act_comment": "displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:644019",
"relation": "IDG (Drug Target)",
"target": "9290",
"properties": {
"id": "cannabidiol targets GPR55",
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"act_value": "6.35",
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}
},
{
"source": "CID:50922675",
"relation": "IDG (Drug Target)",
"target": "673",
"properties": {
"id": "encorafenib targets BRAF",
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"act_relation": "=",
"act_value": "9.328",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:50922675",
"relation": "IDG (Drug Target)",
"target": "1019",
"properties": {
"id": "encorafenib targets CDK4",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.95",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:50922675",
"relation": "IDG (Drug Target)",
"target": "2932",
"properties": {
"id": "encorafenib targets GSK3B",
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"act_value": "6.37",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:50922675",
"relation": "IDG (Drug Target)",
"target": "3654",
"properties": {
"id": "encorafenib targets IRAK1",
"source_label": "encorafenib",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:50922675",
"relation": "IDG (Drug Target)",
"target": "3984",
"properties": {
"id": "encorafenib targets LIMK1",
"source_label": "encorafenib",
"target_label": "LIMK1",
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"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:50922675",
"relation": "IDG (Drug Target)",
"target": "3985",
"properties": {
"id": "encorafenib targets LIMK2",
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"target_label": "LIMK2",
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"act_relation": "=",
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}
},
{
"source": "CID:50922675",
"relation": "IDG (Drug Target)",
"target": "4296",
"properties": {
"id": "encorafenib targets MAP3K11",
"source_label": "encorafenib",
"target_label": "MAP3K11",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:50922675",
"relation": "IDG (Drug Target)",
"target": "5601",
"properties": {
"id": "encorafenib targets MAPK9",
"source_label": "encorafenib",
"target_label": "MAPK9",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.04",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:50922675",
"relation": "IDG (Drug Target)",
"target": "51701",
"properties": {
"id": "encorafenib targets NLK",
"source_label": "encorafenib",
"target_label": "NLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:50922675",
"relation": "IDG (Drug Target)",
"target": "5130",
"properties": {
"id": "encorafenib targets PCYT1A",
"source_label": "encorafenib",
"target_label": "PCYT1A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.39",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:50922675",
"relation": "IDG (Drug Target)",
"target": "10857",
"properties": {
"id": "encorafenib targets PGRMC1",
"source_label": "encorafenib",
"target_label": "PGRMC1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.69",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:50922675",
"relation": "IDG (Drug Target)",
"target": "5894",
"properties": {
"id": "encorafenib targets RAF1",
"source_label": "encorafenib",
"target_label": "RAF1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.523",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:50922675",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "encorafenib targets RIPK2",
"source_label": "encorafenib",
"target_label": "RIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.49",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:50922675",
"relation": "IDG (Drug Target)",
"target": "11035",
"properties": {
"id": "encorafenib targets RIPK3",
"source_label": "encorafenib",
"target_label": "RIPK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.01",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:50922675",
"relation": "IDG (Drug Target)",
"target": "51776",
"properties": {
"id": "encorafenib targets MAP3K20",
"source_label": "encorafenib",
"target_label": "MAP3K20",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.11",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10288191",
"relation": "IDG (Drug Target)",
"target": "5604",
"properties": {
"id": "binimetinib targets MAP2K1",
"source_label": "binimetinib",
"target_label": "MAP2K1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:10288191",
"relation": "IDG (Drug Target)",
"target": "5605",
"properties": {
"id": "binimetinib targets MAP2K2",
"source_label": "binimetinib",
"target_label": "MAP2K2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.9",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:71657455",
"relation": "IDG (Drug Target)",
"target": "3417",
"properties": {
"id": "ivosidenib targets IDH1",
"source_label": "ivosidenib",
"target_label": "IDH1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.149",
"act_comment": "The enzyme and compound were preincubated for 1h",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11250647",
"relation": "IDG (Drug Target)",
"target": "2798",
"properties": {
"id": "elagolix targets GNRHR",
"source_label": "elagolix",
"target_label": "GNRHR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.824",
"act_comment": "determined by competition for [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:50905713",
"relation": "IDG (Drug Target)",
"target": "5291",
"properties": {
"id": "duvelisib targets PIK3CB",
"source_label": "duvelisib",
"target_label": "PIK3CB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.07",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:50905713",
"relation": "IDG (Drug Target)",
"target": "5293",
"properties": {
"id": "duvelisib targets PIK3CD",
"source_label": "duvelisib",
"target_label": "PIK3CD",
"act_type": "Kd",
"act_relation": "=",
"act_value": "10.638",
"act_comment": "Enzymatic assay at 3mM ATP (nM)",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:50905713",
"relation": "IDG (Drug Target)",
"target": "5294",
"properties": {
"id": "duvelisib targets PIK3CG",
"source_label": "duvelisib",
"target_label": "PIK3CG",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.62",
"act_comment": "Enzymatic assay at 3mM ATP (nM)",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11511120",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "dacomitinib targets EGFR",
"source_label": "dacomitinib",
"target_label": "EGFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.222",
"act_comment": "ELISA-Based erbB Kinase Assay with 20 uM [ATP]",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11511120",
"relation": "IDG (Drug Target)",
"target": "2064",
"properties": {
"id": "dacomitinib targets ERBB2",
"source_label": "dacomitinib",
"target_label": "ERBB2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.34",
"act_comment": "ELISA-Based erbB Kinase Assay with 20 uM [ATP]",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11511120",
"relation": "IDG (Drug Target)",
"target": "2066",
"properties": {
"id": "dacomitinib targets ERBB4",
"source_label": "dacomitinib",
"target_label": "ERBB4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.133",
"act_comment": "ELISA-Based erbB Kinase Assay with 20 uM [ATP]",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11511120",
"relation": "IDG (Drug Target)",
"target": "2580",
"properties": {
"id": "dacomitinib targets GAK",
"source_label": "dacomitinib",
"target_label": "GAK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.78",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11511120",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "dacomitinib targets LCK",
"source_label": "dacomitinib",
"target_label": "LCK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.03",
"act_comment": "Inhibition of LCK (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11511120",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "dacomitinib targets RIPK2",
"source_label": "dacomitinib",
"target_label": "RIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11511120",
"relation": "IDG (Drug Target)",
"target": "6714",
"properties": {
"id": "dacomitinib targets SRC",
"source_label": "dacomitinib",
"target_label": "SRC",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.96",
"act_comment": "Inhibition of Src (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:135565082",
"relation": "IDG (Drug Target)",
"target": "142",
"properties": {
"id": "talazoparib tosylate targets PARP1",
"source_label": "talazoparib tosylate",
"target_label": "PARP1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.921",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:135565082",
"relation": "IDG (Drug Target)",
"target": "10038",
"properties": {
"id": "talazoparib tosylate targets PARP2",
"source_label": "talazoparib tosylate",
"target_label": "PARP2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.06",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71731823",
"relation": "IDG (Drug Target)",
"target": "238",
"properties": {
"id": "lorlatinib targets ALK",
"source_label": "lorlatinib",
"target_label": "ALK",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.959",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71731823",
"relation": "IDG (Drug Target)",
"target": "2241",
"properties": {
"id": "lorlatinib targets FER",
"source_label": "lorlatinib",
"target_label": "FER",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.481",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71731823",
"relation": "IDG (Drug Target)",
"target": "2242",
"properties": {
"id": "lorlatinib targets FES",
"source_label": "lorlatinib",
"target_label": "FES",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.222",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71731823",
"relation": "IDG (Drug Target)",
"target": "2444",
"properties": {
"id": "lorlatinib targets FRK",
"source_label": "lorlatinib",
"target_label": "FRK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.28",
"act_comment": "Inhibition of FRK (unknown origin) by TR-FRET-based Z'-LYTE assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71731823",
"relation": "IDG (Drug Target)",
"target": "4058",
"properties": {
"id": "lorlatinib targets LTK",
"source_label": "lorlatinib",
"target_label": "LTK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.569",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71731823",
"relation": "IDG (Drug Target)",
"target": "4914",
"properties": {
"id": "lorlatinib targets NTRK1",
"source_label": "lorlatinib",
"target_label": "NTRK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.62",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71731823",
"relation": "IDG (Drug Target)",
"target": "4915",
"properties": {
"id": "lorlatinib targets NTRK2",
"source_label": "lorlatinib",
"target_label": "NTRK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.638",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71731823",
"relation": "IDG (Drug Target)",
"target": "4916",
"properties": {
"id": "lorlatinib targets NTRK3",
"source_label": "lorlatinib",
"target_label": "NTRK3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.337",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71731823",
"relation": "IDG (Drug Target)",
"target": "5747",
"properties": {
"id": "lorlatinib targets PTK2",
"source_label": "lorlatinib",
"target_label": "PTK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71731823",
"relation": "IDG (Drug Target)",
"target": "2185",
"properties": {
"id": "lorlatinib targets PTK2B",
"source_label": "lorlatinib",
"target_label": "PTK2B",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.854",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71731823",
"relation": "IDG (Drug Target)",
"target": "6098",
"properties": {
"id": "lorlatinib targets ROS1",
"source_label": "lorlatinib",
"target_label": "ROS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.301",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71731823",
"relation": "IDG (Drug Target)",
"target": "10188",
"properties": {
"id": "lorlatinib targets TNK2",
"source_label": "lorlatinib",
"target_label": "TNK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11753673",
"relation": "IDG (Drug Target)",
"target": "1128",
"properties": {
"id": "revefenacin targets CHRM1",
"source_label": "revefenacin",
"target_label": "CHRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.38",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11753673",
"relation": "IDG (Drug Target)",
"target": "1129",
"properties": {
"id": "revefenacin targets CHRM2",
"source_label": "revefenacin",
"target_label": "CHRM2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.52",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11753673",
"relation": "IDG (Drug Target)",
"target": "1131",
"properties": {
"id": "revefenacin targets CHRM3",
"source_label": "revefenacin",
"target_label": "CHRM3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.75",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11753673",
"relation": "IDG (Drug Target)",
"target": "1132",
"properties": {
"id": "revefenacin targets CHRM4",
"source_label": "revefenacin",
"target_label": "CHRM4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.26",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11753673",
"relation": "IDG (Drug Target)",
"target": "1133",
"properties": {
"id": "revefenacin targets CHRM5",
"source_label": "revefenacin",
"target_label": "CHRM5",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.2",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:25166913",
"relation": "IDG (Drug Target)",
"target": "6608",
"properties": {
"id": "glasdegib targets SMO",
"source_label": "glasdegib",
"target_label": "SMO",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.301",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:46188928",
"relation": "IDG (Drug Target)",
"target": "4914",
"properties": {
"id": "larotrectinib targets NTRK1",
"source_label": "larotrectinib",
"target_label": "NTRK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.187",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:46188928",
"relation": "IDG (Drug Target)",
"target": "4915",
"properties": {
"id": "larotrectinib targets NTRK2",
"source_label": "larotrectinib",
"target_label": "NTRK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.092",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:46188928",
"relation": "IDG (Drug Target)",
"target": "4916",
"properties": {
"id": "larotrectinib targets NTRK3",
"source_label": "larotrectinib",
"target_label": "NTRK3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.975",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "22848",
"properties": {
"id": "gilteritinib targets AAK1",
"source_label": "gilteritinib",
"target_label": "AAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.6",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "51703",
"properties": {
"id": "gilteritinib targets ACSL5",
"source_label": "gilteritinib",
"target_label": "ACSL5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "90",
"properties": {
"id": "gilteritinib targets ACVR1",
"source_label": "gilteritinib",
"target_label": "ACVR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.41",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "57143",
"properties": {
"id": "gilteritinib targets ADCK1",
"source_label": "gilteritinib",
"target_label": "ADCK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "238",
"properties": {
"id": "gilteritinib targets ALK",
"source_label": "gilteritinib",
"target_label": "ALK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.82",
"act_comment": "Inhibition Assay: A recombinant retrovirus was created from expression plasmid FLAG-EML4-ALKv1/pMX-iresCD8 in which cDNA for EMLA-ALK fusion protein v1 was integrated, and injected into mouse lymphoid cell line BA/F3 cells. Using a magnetic bead reagent for cell separation and a purification column (anti-CD8 monoclonal antibody immobilized on magnetic beads and a MiniMACS purification column both are products of MilteDyi Biotec Inc.), cell surface CD8-expressing cells were purified to establish EML4-ALK fusion protein v1-expressing BA/F3 cells. From the cells, EML4-ALK fusion protein v1 was purified and subjected to kinase activity evaluation. EML4-ALK fusion protein v1 was investigated for its phosphorylation activity toward a peptide substrate by using a kinase activity detection kit (HTRF KinEASE-TK Cisbio Inc.). Test compounds were each added to a reaction solution containing the enzyme protein to give 8 final concentrations from 1000 nM to 0.3 nM, followed by addition of",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "6790",
"properties": {
"id": "gilteritinib targets AURKA",
"source_label": "gilteritinib",
"target_label": "AURKA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "558",
"properties": {
"id": "gilteritinib targets AXL",
"source_label": "gilteritinib",
"target_label": "AXL",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.1",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "55589",
"properties": {
"id": "gilteritinib targets BMP2K",
"source_label": "gilteritinib",
"target_label": "BMP2K",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.34",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "657",
"properties": {
"id": "gilteritinib targets BMPR1A",
"source_label": "gilteritinib",
"target_label": "BMPR1A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "658",
"properties": {
"id": "gilteritinib targets BMPR1B",
"source_label": "gilteritinib",
"target_label": "BMPR1B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "699",
"properties": {
"id": "gilteritinib targets BUB1",
"source_label": "gilteritinib",
"target_label": "BUB1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.72",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "817",
"properties": {
"id": "gilteritinib targets CAMK2D",
"source_label": "gilteritinib",
"target_label": "CAMK2D",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "818",
"properties": {
"id": "gilteritinib targets CAMK2G",
"source_label": "gilteritinib",
"target_label": "CAMK2G",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.77",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "814",
"properties": {
"id": "gilteritinib targets CAMK4",
"source_label": "gilteritinib",
"target_label": "CAMK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.38",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "1459",
"properties": {
"id": "gilteritinib targets CSNK2A2",
"source_label": "gilteritinib",
"target_label": "CSNK2A2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.02",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "1537",
"properties": {
"id": "gilteritinib targets CYC1",
"source_label": "gilteritinib",
"target_label": "CYC1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "1718",
"properties": {
"id": "gilteritinib targets DHCR24",
"source_label": "gilteritinib",
"target_label": "DHCR24",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "2051",
"properties": {
"id": "gilteritinib targets EPHB6",
"source_label": "gilteritinib",
"target_label": "EPHB6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.62",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "2241",
"properties": {
"id": "gilteritinib targets FER",
"source_label": "gilteritinib",
"target_label": "FER",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.73",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "gilteritinib targets FLT3",
"source_label": "gilteritinib",
"target_label": "FLT3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.301",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "2580",
"properties": {
"id": "gilteritinib targets GAK",
"source_label": "gilteritinib",
"target_label": "GAK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "11213",
"properties": {
"id": "gilteritinib targets IRAK3",
"source_label": "gilteritinib",
"target_label": "IRAK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.15",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "9113",
"properties": {
"id": "gilteritinib targets LATS1",
"source_label": "gilteritinib",
"target_label": "LATS1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "4058",
"properties": {
"id": "gilteritinib targets LTK",
"source_label": "gilteritinib",
"target_label": "LTK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "5605",
"properties": {
"id": "gilteritinib targets MAP2K2",
"source_label": "gilteritinib",
"target_label": "MAP2K2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "4296",
"properties": {
"id": "gilteritinib targets MAP3K11",
"source_label": "gilteritinib",
"target_label": "MAP3K11",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "10746",
"properties": {
"id": "gilteritinib targets MAP3K2",
"source_label": "gilteritinib",
"target_label": "MAP3K2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.27",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "11184",
"properties": {
"id": "gilteritinib targets MAP4K1",
"source_label": "gilteritinib",
"target_label": "MAP4K1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.97",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "5871",
"properties": {
"id": "gilteritinib targets MAP4K2",
"source_label": "gilteritinib",
"target_label": "MAP4K2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.61",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "8491",
"properties": {
"id": "gilteritinib targets MAP4K3",
"source_label": "gilteritinib",
"target_label": "MAP4K3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.22",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "9448",
"properties": {
"id": "gilteritinib targets MAP4K4",
"source_label": "gilteritinib",
"target_label": "MAP4K4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.7",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "5602",
"properties": {
"id": "gilteritinib targets MAPK10",
"source_label": "gilteritinib",
"target_label": "MAPK10",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "225689",
"properties": {
"id": "gilteritinib targets MAPK15",
"source_label": "gilteritinib",
"target_label": "MAPK15",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.58",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "5599",
"properties": {
"id": "gilteritinib targets MAPK8",
"source_label": "gilteritinib",
"target_label": "MAPK8",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.13",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "5601",
"properties": {
"id": "gilteritinib targets MAPK9",
"source_label": "gilteritinib",
"target_label": "MAPK9",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "10461",
"properties": {
"id": "gilteritinib targets MERTK",
"source_label": "gilteritinib",
"target_label": "MERTK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "4486",
"properties": {
"id": "gilteritinib targets MST1R",
"source_label": "gilteritinib",
"target_label": "MST1R",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "4638",
"properties": {
"id": "gilteritinib targets MYLK",
"source_label": "gilteritinib",
"target_label": "MYLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.73",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "4751",
"properties": {
"id": "gilteritinib targets NEK2",
"source_label": "gilteritinib",
"target_label": "NEK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.61",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "4914",
"properties": {
"id": "gilteritinib targets NTRK1",
"source_label": "gilteritinib",
"target_label": "NTRK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.96",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "gilteritinib targets PDGFRB",
"source_label": "gilteritinib",
"target_label": "PDGFRB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "5261",
"properties": {
"id": "gilteritinib targets PHKG2",
"source_label": "gilteritinib",
"target_label": "PHKG2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.32",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "10733",
"properties": {
"id": "gilteritinib targets PLK4",
"source_label": "gilteritinib",
"target_label": "PLK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.75",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "5578",
"properties": {
"id": "gilteritinib targets PRKCA",
"source_label": "gilteritinib",
"target_label": "PRKCA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.23",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "2185",
"properties": {
"id": "gilteritinib targets PTK2B",
"source_label": "gilteritinib",
"target_label": "PTK2B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.29",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "5901",
"properties": {
"id": "gilteritinib targets RAN",
"source_label": "gilteritinib",
"target_label": "RAN",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "gilteritinib targets RET",
"source_label": "gilteritinib",
"target_label": "RET",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.47",
"act_comment": "Inhibition Assay: A partial protein of only a kinase domain of RET protein was purchased from Carna Biosciences Inc., Japan. The phosphorylation activity toward a peptide substrate was investigated using an EZ reader (Caliper). Test compounds were each mixed with a protein solution to give 8 final concentrations from 100 nM to 0.03 nM, followed by addition of a mixed liquid of ATP and substrate peptide (Caliper) and reaction for 30 minutes. The ATP concentration used was 100 \u00c2\u00b5M. A reaction liquid which contained protein but no test compound (in which the solvent DMSO alone was added at 0.8% in place of the test compound) was prepared, followed by reaction in the same manner with or without ATP addition. In the absence of the test compound, the phosphorylation peptide peak without ATP addition and with ATP addition was assumed to be 100% inhibition and 0% inhibition, respectively.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "8767",
"properties": {
"id": "gilteritinib targets RIPK2",
"source_label": "gilteritinib",
"target_label": "RIPK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.32",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "6098",
"properties": {
"id": "gilteritinib targets ROS1",
"source_label": "gilteritinib",
"target_label": "ROS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.72",
"act_comment": "Inhibition Assay: A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Example 5, except that the ATP concentration in the mixed solution of ATP and substrate peptide (Caliper) was 50 uM. Test Example 5: A partial protein of only a kinase domain of RET protein was purchased from Carna Biosciences Inc., Japan. The phosphorylation activity toward a peptide substrate was investigated using an EZ reader (Caliper). Test compounds were each mixed with a protein solution to give 8 final concentrations from 100 nM to 0.03 nM, followed by addition of a mixed liquid of ATP and substrate peptide (Caliper) and reaction for 30 minutes. The ATP concentration used was 100 \u00c3\u201a\u00c2\u00b5M. A reaction liquid which contained protein but no test compound (in which the solvent DMSO alone was added at 0.8% in place of the test compound) was prepared, followed by reaction in the same manner with or without ATP addition.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "292",
"properties": {
"id": "gilteritinib targets SLC25A5",
"source_label": "gilteritinib",
"target_label": "SLC25A5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "293",
"properties": {
"id": "gilteritinib targets SLC25A6",
"source_label": "gilteritinib",
"target_label": "SLC25A6",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "9748",
"properties": {
"id": "gilteritinib targets SLK",
"source_label": "gilteritinib",
"target_label": "SLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.17",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "6793",
"properties": {
"id": "gilteritinib targets STK10",
"source_label": "gilteritinib",
"target_label": "STK10",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.83",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "8576",
"properties": {
"id": "gilteritinib targets STK16",
"source_label": "gilteritinib",
"target_label": "STK16",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.53",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "8428",
"properties": {
"id": "gilteritinib targets STK24",
"source_label": "gilteritinib",
"target_label": "STK24",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "8711",
"properties": {
"id": "gilteritinib targets TNK1",
"source_label": "gilteritinib",
"target_label": "TNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.41",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "7284",
"properties": {
"id": "gilteritinib targets TUFM",
"source_label": "gilteritinib",
"target_label": "TUFM",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.33",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "25989",
"properties": {
"id": "gilteritinib targets ULK3",
"source_label": "gilteritinib",
"target_label": "ULK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49803313",
"relation": "IDG (Drug Target)",
"target": "7525",
"properties": {
"id": "gilteritinib targets YES1",
"source_label": "gilteritinib",
"target_label": "YES1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71242808",
"relation": "IDG (Drug Target)",
"target": "846",
"properties": {
"id": "evocalcet targets CASR",
"source_label": "evocalcet",
"target_label": "CASR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.032",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44472635",
"relation": "IDG (Drug Target)",
"target": "155",
"properties": {
"id": "vibegron targets ADRB3",
"source_label": "vibegron",
"target_label": "ADRB3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.959",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44230999",
"relation": "IDG (Drug Target)",
"target": "5732",
"properties": {
"id": "omidenepag isopropyl targets PTGER2",
"source_label": "omidenepag isopropyl",
"target_label": "PTGER2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.081",
"act_comment": "activity measured for the active metabolite (omidenepag)",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44599207",
"relation": "IDG (Drug Target)",
"target": "1901",
"properties": {
"id": "siponimod targets S1PR1",
"source_label": "siponimod",
"target_label": "S1PR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.409",
"act_comment": "Possible mechanism of action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44599207",
"relation": "IDG (Drug Target)",
"target": "8698",
"properties": {
"id": "siponimod targets S1PR4",
"source_label": "siponimod",
"target_label": "S1PR4",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.125",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44599207",
"relation": "IDG (Drug Target)",
"target": "53637",
"properties": {
"id": "siponimod targets S1PR5",
"source_label": "siponimod",
"target_label": "S1PR5",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.009",
"act_comment": "Possible mechanism of action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:67462786",
"relation": "IDG (Drug Target)",
"target": "2260",
"properties": {
"id": "erdafitinib targets FGFR1",
"source_label": "erdafitinib",
"target_label": "FGFR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.921",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:67462786",
"relation": "IDG (Drug Target)",
"target": "2263",
"properties": {
"id": "erdafitinib targets FGFR2",
"source_label": "erdafitinib",
"target_label": "FGFR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.602",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:67462786",
"relation": "IDG (Drug Target)",
"target": "2261",
"properties": {
"id": "erdafitinib targets FGFR3",
"source_label": "erdafitinib",
"target_label": "FGFR3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.523",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:67462786",
"relation": "IDG (Drug Target)",
"target": "2264",
"properties": {
"id": "erdafitinib targets FGFR4",
"source_label": "erdafitinib",
"target_label": "FGFR4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.244",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:67462786",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "erdafitinib targets KDR",
"source_label": "erdafitinib",
"target_label": "KDR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.434",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:56649450",
"relation": "IDG (Drug Target)",
"target": "5290",
"properties": {
"id": "alpelisib targets PIK3CA",
"source_label": "alpelisib",
"target_label": "PIK3CA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.337",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:56649450",
"relation": "IDG (Drug Target)",
"target": "5293",
"properties": {
"id": "alpelisib targets PIK3CD",
"source_label": "alpelisib",
"target_label": "PIK3CD",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Inhibition of P110delta (unknown origin) using PIP2:PS as substrate by TR-FRET assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:56649450",
"relation": "IDG (Drug Target)",
"target": "5294",
"properties": {
"id": "alpelisib targets PIK3CG",
"source_label": "alpelisib",
"target_label": "PIK3CG",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.6",
"act_comment": "Inhibition of P110gamma (unknown origin) using PIP2:PS as substrate by TR-FRET assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9941379",
"relation": "IDG (Drug Target)",
"target": "4157",
"properties": {
"id": "bremelanotide targets MC1R",
"source_label": "bremelanotide",
"target_label": "MC1R",
"act_type": "EC50",
"act_relation": "=",
"act_value": "10.02",
"act_comment": "Agonist activity at human MC1R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9941379",
"relation": "IDG (Drug Target)",
"target": "4159",
"properties": {
"id": "bremelanotide targets MC3R",
"source_label": "bremelanotide",
"target_label": "MC3R",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.62",
"act_comment": "Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:9941379",
"relation": "IDG (Drug Target)",
"target": "4160",
"properties": {
"id": "bremelanotide targets MC4R",
"source_label": "bremelanotide",
"target_label": "MC4R",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Functional evaluation of PT\u00e2\u20ac",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9941379",
"relation": "IDG (Drug Target)",
"target": "4161",
"properties": {
"id": "bremelanotide targets MC5R",
"source_label": "bremelanotide",
"target_label": "MC5R",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71481097",
"relation": "IDG (Drug Target)",
"target": "7514",
"properties": {
"id": "selinexor targets XPO1",
"source_label": "selinexor",
"target_label": "XPO1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.7",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:121489720",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "darolutamide targets AR",
"source_label": "darolutamide",
"target_label": "AR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.187",
"act_comment": "Competitively inhibits androgen binding",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24831714",
"relation": "IDG (Drug Target)",
"target": "6523",
"properties": {
"id": "sotagliflozin targets SLC5A1",
"source_label": "sotagliflozin",
"target_label": "SLC5A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.444",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24831714",
"relation": "IDG (Drug Target)",
"target": "6524",
"properties": {
"id": "sotagliflozin targets SLC5A2",
"source_label": "sotagliflozin",
"target_label": "SLC5A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.745",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "quizartinib targets ABL1",
"source_label": "quizartinib",
"target_label": "ABL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "Binding affinity to ABL1 T315I mutant",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "1436",
"properties": {
"id": "quizartinib targets CSF1R",
"source_label": "quizartinib",
"target_label": "CSF1R",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "Binding affinity to CSF1R",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "780",
"properties": {
"id": "quizartinib targets DDR1",
"source_label": "quizartinib",
"target_label": "DDR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.09",
"act_comment": "Binding affinity to DDR1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "4921",
"properties": {
"id": "quizartinib targets DDR2",
"source_label": "quizartinib",
"target_label": "DDR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "Binding affinity to DDR2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "2321",
"properties": {
"id": "quizartinib targets FLT1",
"source_label": "quizartinib",
"target_label": "FLT1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.39",
"act_comment": "Binding affinity to FLT1",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "quizartinib targets FLT3",
"source_label": "quizartinib",
"target_label": "FLT3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.796",
"act_comment": "FLT3 binding affinity in biochemical assay",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "2324",
"properties": {
"id": "quizartinib targets FLT4",
"source_label": "quizartinib",
"target_label": "FLT4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.39",
"act_comment": "Binding affinity to FLT4",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "147746",
"properties": {
"id": "quizartinib targets HIPK4",
"source_label": "quizartinib",
"target_label": "HIPK4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "Binding affinity to HIPK4",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "quizartinib targets KDR",
"source_label": "quizartinib",
"target_label": "KDR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.06",
"act_comment": "Binding affinity to VEGFR2",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "quizartinib targets KIT",
"source_label": "quizartinib",
"target_label": "KIT",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "Binding affinity to cKIT",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "11183",
"properties": {
"id": "quizartinib targets MAP4K5",
"source_label": "quizartinib",
"target_label": "MAP4K5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "Binding affinity to MAP4K5",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "225689",
"properties": {
"id": "quizartinib targets MAPK15",
"source_label": "quizartinib",
"target_label": "MAPK15",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Binding affinity to ERK8",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "4593",
"properties": {
"id": "quizartinib targets MUSK",
"source_label": "quizartinib",
"target_label": "MUSK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
"act_comment": "Binding affinity to MUSK",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "4628",
"properties": {
"id": "quizartinib targets MYH10",
"source_label": "quizartinib",
"target_label": "MYH10",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "4638",
"properties": {
"id": "quizartinib targets MYLK",
"source_label": "quizartinib",
"target_label": "MYLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "Binding affinity to MLCK",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "91807",
"properties": {
"id": "quizartinib targets MYLK3",
"source_label": "quizartinib",
"target_label": "MYLK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "Binding constant for MLCK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "4915",
"properties": {
"id": "quizartinib targets NTRK2",
"source_label": "quizartinib",
"target_label": "NTRK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Binding affinity to TRKB",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "4916",
"properties": {
"id": "quizartinib targets NTRK3",
"source_label": "quizartinib",
"target_label": "NTRK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.26",
"act_comment": "Binding affinity to TRKC",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "5156",
"properties": {
"id": "quizartinib targets PDGFRA",
"source_label": "quizartinib",
"target_label": "PDGFRA",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "Binding affinity to PDGFRalpha",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "quizartinib targets PDGFRB",
"source_label": "quizartinib",
"target_label": "PDGFRB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "Binding affinity to PDGFRbeta",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "quizartinib targets RET",
"source_label": "quizartinib",
"target_label": "RET",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.8",
"act_comment": "Binding affinity to RET",
"act_source": "CHEMBL"
}
},
{
"source": "CID:24889392",
"relation": "IDG (Drug Target)",
"target": "8737",
"properties": {
"id": "quizartinib targets RIPK1",
"source_label": "quizartinib",
"target_label": "RIPK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "Binding constant for RIPK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25151352",
"relation": "IDG (Drug Target)",
"target": "23097",
"properties": {
"id": "pexidartinib targets CDK19",
"source_label": "pexidartinib",
"target_label": "CDK19",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:25151352",
"relation": "IDG (Drug Target)",
"target": "1436",
"properties": {
"id": "pexidartinib targets CSF1R",
"source_label": "pexidartinib",
"target_label": "CSF1R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.88",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:25151352",
"relation": "IDG (Drug Target)",
"target": "2321",
"properties": {
"id": "pexidartinib targets FLT1",
"source_label": "pexidartinib",
"target_label": "FLT1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.06",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:25151352",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "pexidartinib targets FLT3",
"source_label": "pexidartinib",
"target_label": "FLT3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.79",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:25151352",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "pexidartinib targets KDR",
"source_label": "pexidartinib",
"target_label": "KDR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.36",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:25151352",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "pexidartinib targets KIT",
"source_label": "pexidartinib",
"target_label": "KIT",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.56",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:25151352",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "pexidartinib targets LCK",
"source_label": "pexidartinib",
"target_label": "LCK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:25151352",
"relation": "IDG (Drug Target)",
"target": "4916",
"properties": {
"id": "pexidartinib targets NTRK3",
"source_label": "pexidartinib",
"target_label": "NTRK3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.05",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:25151352",
"relation": "IDG (Drug Target)",
"target": "5588",
"properties": {
"id": "pexidartinib targets PRKCQ",
"source_label": "pexidartinib",
"target_label": "PRKCQ",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25141092",
"relation": "IDG (Drug Target)",
"target": "238",
"properties": {
"id": "entrectinib targets ALK",
"source_label": "entrectinib",
"target_label": "ALK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.92",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:25141092",
"relation": "IDG (Drug Target)",
"target": "6790",
"properties": {
"id": "entrectinib targets AURKA",
"source_label": "entrectinib",
"target_label": "AURKA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.67",
"act_comment": "Inhibition of AUR2 (unknown origin) in presence of gamma33-ATP",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25141092",
"relation": "IDG (Drug Target)",
"target": "9212",
"properties": {
"id": "entrectinib targets AURKB",
"source_label": "entrectinib",
"target_label": "AURKB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "Biochemical Assay: The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A specific substrate was incubated with the kinase in appropriate buffer conditions in the presence of ATP traced with .sup.33P-.gamma.-ATP (gamma phosphate-labeled, Redivue.TM. Code Number AH9968, 1000-3000 Ci/mmole, Amersham Biosciences Piscataway, N.J., USA), optimal cofactors and test compound.At the end of the phosphorylation reaction, more than 98% cold and radioactive ATP were captured by an excess of Dowex ion exchange resin. The resin was allowed to settle to the bottom of reaction wells by gravity. Supernatant, containing substrate peptide, was subsequently withdrawn and transferred into a counting plate, and radioactivity (corresponding to phosphate incorporated into peptide) was evaluated by .beta.-counting. Assay Conditions:The kinase assay was run with a final enzyme concentration of 6 nM, in the prese",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25141092",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "entrectinib targets FLT3",
"source_label": "entrectinib",
"target_label": "FLT3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.79",
"act_comment": "Inhibition of FLT3 (unknown origin) in presence of gamma33-ATP",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25141092",
"relation": "IDG (Drug Target)",
"target": "3480",
"properties": {
"id": "entrectinib targets IGF1R",
"source_label": "entrectinib",
"target_label": "IGF1R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.91",
"act_comment": "Inhibition of IGF1R (unknown origin) in presence of gamma33-ATP",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25141092",
"relation": "IDG (Drug Target)",
"target": "3643",
"properties": {
"id": "entrectinib targets INSR",
"source_label": "entrectinib",
"target_label": "INSR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Inhibition of IR (unknown origin) in presence of gamma33-ATP",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25141092",
"relation": "IDG (Drug Target)",
"target": "3716",
"properties": {
"id": "entrectinib targets JAK1",
"source_label": "entrectinib",
"target_label": "JAK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.95",
"act_comment": "Inhibition of JAK1 (unknown origin) in presence of gamma33-ATP",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25141092",
"relation": "IDG (Drug Target)",
"target": "3717",
"properties": {
"id": "entrectinib targets JAK2",
"source_label": "entrectinib",
"target_label": "JAK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:25141092",
"relation": "IDG (Drug Target)",
"target": "3718",
"properties": {
"id": "entrectinib targets JAK3",
"source_label": "entrectinib",
"target_label": "JAK3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Inhibition of JAK3 (unknown origin) in presence of gamma33-ATP",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25141092",
"relation": "IDG (Drug Target)",
"target": "4914",
"properties": {
"id": "entrectinib targets NTRK1",
"source_label": "entrectinib",
"target_label": "NTRK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:25141092",
"relation": "IDG (Drug Target)",
"target": "4915",
"properties": {
"id": "entrectinib targets NTRK2",
"source_label": "entrectinib",
"target_label": "NTRK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:25141092",
"relation": "IDG (Drug Target)",
"target": "4916",
"properties": {
"id": "entrectinib targets NTRK3",
"source_label": "entrectinib",
"target_label": "NTRK3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:25141092",
"relation": "IDG (Drug Target)",
"target": "5747",
"properties": {
"id": "entrectinib targets PTK2",
"source_label": "entrectinib",
"target_label": "PTK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.85",
"act_comment": "Inhibition of FAK (unknown origin) in presence of gamma33-ATP",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25141092",
"relation": "IDG (Drug Target)",
"target": "5753",
"properties": {
"id": "entrectinib targets PTK6",
"source_label": "entrectinib",
"target_label": "PTK6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.71",
"act_comment": "Inhibition of BRK (unknown origin) in presence of gamma33-ATP",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25141092",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "entrectinib targets RET",
"source_label": "entrectinib",
"target_label": "RET",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "Inhibition of RET (unknown origin) in presence of gamma33-ATP",
"act_source": "CHEMBL"
}
},
{
"source": "CID:25141092",
"relation": "IDG (Drug Target)",
"target": "6098",
"properties": {
"id": "entrectinib targets ROS1",
"source_label": "entrectinib",
"target_label": "ROS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.15",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:25141092",
"relation": "IDG (Drug Target)",
"target": "10188",
"properties": {
"id": "entrectinib targets TNK2",
"source_label": "entrectinib",
"target_label": "TNK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:58557659",
"relation": "IDG (Drug Target)",
"target": "3716",
"properties": {
"id": "upadacitinib targets JAK1",
"source_label": "upadacitinib",
"target_label": "JAK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.33",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:58557659",
"relation": "IDG (Drug Target)",
"target": "3717",
"properties": {
"id": "upadacitinib targets JAK2",
"source_label": "upadacitinib",
"target_label": "JAK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "22848",
"properties": {
"id": "fedratinib targets AAK1",
"source_label": "fedratinib",
"target_label": "AAK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.46",
"act_comment": "Binding constant for AAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "fedratinib targets ABL1",
"source_label": "fedratinib",
"target_label": "ABL1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "Binding constant for ABL1(E255K)-phosphorylated kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "27",
"properties": {
"id": "fedratinib targets ABL2",
"source_label": "fedratinib",
"target_label": "ABL2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.24",
"act_comment": "Binding constant for ABL2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "90",
"properties": {
"id": "fedratinib targets ACVR1",
"source_label": "fedratinib",
"target_label": "ACVR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.82",
"act_comment": "Binding constant for ACVR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "57143",
"properties": {
"id": "fedratinib targets ADCK1",
"source_label": "fedratinib",
"target_label": "ADCK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.64",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "238",
"properties": {
"id": "fedratinib targets ALK",
"source_label": "fedratinib",
"target_label": "ALK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Binding constant for ALK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "9212",
"properties": {
"id": "fedratinib targets AURKB",
"source_label": "fedratinib",
"target_label": "AURKB",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.31",
"act_comment": "Binding constant for AURKB kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "6795",
"properties": {
"id": "fedratinib targets AURKC",
"source_label": "fedratinib",
"target_label": "AURKC",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.46",
"act_comment": "Binding constant for AURKC kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "558",
"properties": {
"id": "fedratinib targets AXL",
"source_label": "fedratinib",
"target_label": "AXL",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "Binding constant for AXL kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "640",
"properties": {
"id": "fedratinib targets BLK",
"source_label": "fedratinib",
"target_label": "BLK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Binding constant for BLK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "55589",
"properties": {
"id": "fedratinib targets BMP2K",
"source_label": "fedratinib",
"target_label": "BMP2K",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.5",
"act_comment": "Binding constant for BIKE kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "658",
"properties": {
"id": "fedratinib targets BMPR1B",
"source_label": "fedratinib",
"target_label": "BMPR1B",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "Binding constant for BMPR1B kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "23476",
"properties": {
"id": "fedratinib targets BRD4",
"source_label": "fedratinib",
"target_label": "BRD4",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.79",
"act_comment": "Binding affinity to recombinant human His6-TEV protease-tagged BRD4 bromodomain 1 expressed in bacteria by isothermal titration calorimetric method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "676",
"properties": {
"id": "fedratinib targets BRDT",
"source_label": "fedratinib",
"target_label": "BRDT",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "Inhibition of N-terminal 6His-tagged human BRDT bromodomain 1 (21 to 137 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated histone H4 peptide (1 to 21 residues) containing KAc (K5/8/12/16Ac) as substrate by Alpha screen assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "695",
"properties": {
"id": "fedratinib targets BTK",
"source_label": "fedratinib",
"target_label": "BTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "Binding constant for BTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "57118",
"properties": {
"id": "fedratinib targets CAMK1D",
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}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "815",
"properties": {
"id": "fedratinib targets CAMK2A",
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}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "817",
"properties": {
"id": "fedratinib targets CAMK2D",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "818",
"properties": {
"id": "fedratinib targets CAMK2G",
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}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "5128",
"properties": {
"id": "fedratinib targets CDK17",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "1019",
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"id": "fedratinib targets CDK4",
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}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "1022",
"properties": {
"id": "fedratinib targets CDK7",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "1147",
"properties": {
"id": "fedratinib targets CHUK",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "11113",
"properties": {
"id": "fedratinib targets CIT",
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"act_relation": "=",
"act_value": "6.85",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "79934",
"properties": {
"id": "fedratinib targets COQ8B",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "1436",
"properties": {
"id": "fedratinib targets CSF1R",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "1457",
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"id": "fedratinib targets CSNK2A1",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "1459",
"properties": {
"id": "fedratinib targets CSNK2A2",
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"act_relation": "=",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "1612",
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"id": "fedratinib targets DAPK1",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "23604",
"properties": {
"id": "fedratinib targets DAPK2",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "1613",
"properties": {
"id": "fedratinib targets DAPK3",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "9201",
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"id": "fedratinib targets DCLK1",
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"act_value": "6.72",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "166614",
"properties": {
"id": "fedratinib targets DCLK2",
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"act_relation": "=",
"act_value": "6.06",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "85443",
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"id": "fedratinib targets DCLK3",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "4921",
"properties": {
"id": "fedratinib targets DDR2",
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}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "1760",
"properties": {
"id": "fedratinib targets DMPK",
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}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "fedratinib targets EGFR",
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"act_value": "6.24",
"act_comment": "Binding constant for EGFR(T790M) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "27102",
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"id": "fedratinib targets EIF2AK1",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "440275",
"properties": {
"id": "fedratinib targets EIF2AK4",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "2041",
"properties": {
"id": "fedratinib targets EPHA1",
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"act_type": "Kd",
"act_relation": "=",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "2051",
"properties": {
"id": "fedratinib targets EPHB6",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "2242",
"properties": {
"id": "fedratinib targets FES",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.28",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "2260",
"properties": {
"id": "fedratinib targets FGFR1",
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"act_type": "Kd",
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"act_value": "6.55",
"act_comment": "Binding constant for FGFR1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "2263",
"properties": {
"id": "fedratinib targets FGFR2",
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"act_type": "Kd",
"act_relation": "=",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "2261",
"properties": {
"id": "fedratinib targets FGFR3",
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"act_relation": "=",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "2268",
"properties": {
"id": "fedratinib targets FGR",
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"act_relation": "=",
"act_value": "7.09",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "fedratinib targets FLT3",
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"act_type": "IC50",
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"act_value": "7.82",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "2444",
"properties": {
"id": "fedratinib targets FRK",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.7",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "2534",
"properties": {
"id": "fedratinib targets FYN",
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"act_relation": "=",
"act_value": "7.42",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "2580",
"properties": {
"id": "fedratinib targets GAK",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "8.96",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "2868",
"properties": {
"id": "fedratinib targets GRK4",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.77",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "204851",
"properties": {
"id": "fedratinib targets HIPK1",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "Binding constant for HIPK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "28996",
"properties": {
"id": "fedratinib targets HIPK2",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.0",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "147746",
"properties": {
"id": "fedratinib targets HIPK4",
"source_label": "fedratinib",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.66",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "3551",
"properties": {
"id": "fedratinib targets IKBKB",
"source_label": "fedratinib",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
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"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "9641",
"properties": {
"id": "fedratinib targets IKBKE",
"source_label": "fedratinib",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Binding constant for IKK-epsilon kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "3643",
"properties": {
"id": "fedratinib targets INSR",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "Binding constant for INSR kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "3654",
"properties": {
"id": "fedratinib targets IRAK1",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.66",
"act_comment": "Binding constant for IRAK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "11213",
"properties": {
"id": "fedratinib targets IRAK3",
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"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Binding constant for IRAK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "3702",
"properties": {
"id": "fedratinib targets ITK",
"source_label": "fedratinib",
"target_label": "ITK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.31",
"act_comment": "Binding constant for ITK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "3716",
"properties": {
"id": "fedratinib targets JAK1",
"source_label": "fedratinib",
"target_label": "JAK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.97",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "3717",
"properties": {
"id": "fedratinib targets JAK2",
"source_label": "fedratinib",
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"act_type": "IC50",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "wild type JAK2",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "fedratinib targets KIT",
"source_label": "fedratinib",
"target_label": "KIT",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.34",
"act_comment": "Binding constant for KIT(A829P) kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "fedratinib targets LCK",
"source_label": "fedratinib",
"target_label": "LCK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.14",
"act_comment": "Binding constant for LCK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "3984",
"properties": {
"id": "fedratinib targets LIMK1",
"source_label": "fedratinib",
"target_label": "LIMK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.03",
"act_comment": "Binding constant for LIMK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "120892",
"properties": {
"id": "fedratinib targets LRRK2",
"source_label": "fedratinib",
"target_label": "LRRK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.06",
"act_comment": "Binding constant for LRRK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "4067",
"properties": {
"id": "fedratinib targets LYN",
"source_label": "fedratinib",
"target_label": "LYN",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "Binding constant for LYN kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "5607",
"properties": {
"id": "fedratinib targets MAP2K5",
"source_label": "fedratinib",
"target_label": "MAP2K5",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Binding constant for MEK5 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "9175",
"properties": {
"id": "fedratinib targets MAP3K13",
"source_label": "fedratinib",
"target_label": "MAP3K13",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.23",
"act_comment": "Binding constant for LZK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "80122",
"properties": {
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}
},
{
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},
{
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{
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{
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"relation": "IDG (Drug Target)",
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{
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{
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{
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},
{
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},
{
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},
{
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},
{
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},
{
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{
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{
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},
{
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"relation": "IDG (Drug Target)",
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},
{
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"relation": "IDG (Drug Target)",
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{
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},
{
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"relation": "IDG (Drug Target)",
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{
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},
{
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},
{
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{
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{
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{
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},
{
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{
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{
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},
{
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},
{
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"relation": "IDG (Drug Target)",
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{
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},
{
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{
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},
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{
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{
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{
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{
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{
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{
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},
{
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"relation": "IDG (Drug Target)",
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},
{
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"relation": "IDG (Drug Target)",
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},
{
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"relation": "IDG (Drug Target)",
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},
{
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"relation": "IDG (Drug Target)",
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},
{
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"relation": "IDG (Drug Target)",
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},
{
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"relation": "IDG (Drug Target)",
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}
},
{
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"relation": "IDG (Drug Target)",
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},
{
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"relation": "IDG (Drug Target)",
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},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
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},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
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}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "65975",
"properties": {
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}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
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"properties": {
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}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
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"properties": {
"id": "fedratinib targets TAOK2",
"source_label": "fedratinib",
"target_label": "TAOK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Binding constant for TAOK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "29110",
"properties": {
"id": "fedratinib targets TBK1",
"source_label": "fedratinib",
"target_label": "TBK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.04",
"act_comment": "Binding constant for TBK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "7075",
"properties": {
"id": "fedratinib targets TIE1",
"source_label": "fedratinib",
"target_label": "TIE1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.16",
"act_comment": "Binding constant for TIE1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "8711",
"properties": {
"id": "fedratinib targets TNK1",
"source_label": "fedratinib",
"target_label": "TNK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Binding constant for TNK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "10188",
"properties": {
"id": "fedratinib targets TNK2",
"source_label": "fedratinib",
"target_label": "TNK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.19",
"act_comment": "Binding constant for TNK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "7272",
"properties": {
"id": "fedratinib targets TTK",
"source_label": "fedratinib",
"target_label": "TTK",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Binding constant for TTK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "7297",
"properties": {
"id": "fedratinib targets TYK2",
"source_label": "fedratinib",
"target_label": "TYK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "8408",
"properties": {
"id": "fedratinib targets ULK1",
"source_label": "fedratinib",
"target_label": "ULK1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.57",
"act_comment": "Binding constant for ULK1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "9706",
"properties": {
"id": "fedratinib targets ULK2",
"source_label": "fedratinib",
"target_label": "ULK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "Binding constant for ULK2 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "25989",
"properties": {
"id": "fedratinib targets ULK3",
"source_label": "fedratinib",
"target_label": "ULK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.54",
"act_comment": "Binding constant for ULK3 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "7465",
"properties": {
"id": "fedratinib targets WEE1",
"source_label": "fedratinib",
"target_label": "WEE1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "Binding constant for WEE1 kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "7525",
"properties": {
"id": "fedratinib targets YES1",
"source_label": "fedratinib",
"target_label": "YES1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.92",
"act_comment": "Binding constant for YES kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:16722836",
"relation": "IDG (Drug Target)",
"target": "51776",
"properties": {
"id": "fedratinib targets MAP3K20",
"source_label": "fedratinib",
"target_label": "MAP3K20",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.19",
"act_comment": "Binding constant for ZAK kinase domain",
"act_source": "CHEMBL"
}
},
{
"source": "CID:71587953",
"relation": "IDG (Drug Target)",
"target": "6550",
"properties": {
"id": "tenapanor targets SLC9A3",
"source_label": "tenapanor",
"target_label": "SLC9A3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.06",
"act_comment": "wild type",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11518241",
"relation": "IDG (Drug Target)",
"target": "5914",
"properties": {
"id": "trifarotene targets RARA",
"source_label": "trifarotene",
"target_label": "RARA",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.3",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11518241",
"relation": "IDG (Drug Target)",
"target": "5915",
"properties": {
"id": "trifarotene targets RARB",
"source_label": "trifarotene",
"target_label": "RARB",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.9",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11518241",
"relation": "IDG (Drug Target)",
"target": "5916",
"properties": {
"id": "trifarotene targets RARG",
"source_label": "trifarotene",
"target_label": "RARG",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.11",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11610526",
"relation": "IDG (Drug Target)",
"target": "3355",
"properties": {
"id": "lasmiditan targets HTR1F",
"source_label": "lasmiditan",
"target_label": "HTR1F",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.65",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:135565884",
"relation": "IDG (Drug Target)",
"target": "695",
"properties": {
"id": "zanubrutinib targets BTK",
"source_label": "zanubrutinib",
"target_label": "BTK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.52",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:21302490",
"relation": "IDG (Drug Target)",
"target": "148",
"properties": {
"id": "lumateperone targets ADRA1A",
"source_label": "lumateperone",
"target_label": "ADRA1A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.14",
"act_comment": "Inhibition of adrenergic alpha1A receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:21302490",
"relation": "IDG (Drug Target)",
"target": "147",
"properties": {
"id": "lumateperone targets ADRA1B",
"source_label": "lumateperone",
"target_label": "ADRA1B",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.51",
"act_comment": "Inhibition of adrenergic alpha1B receptor (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:21302490",
"relation": "IDG (Drug Target)",
"target": "1812",
"properties": {
"id": "lumateperone targets DRD1",
"source_label": "lumateperone",
"target_label": "DRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.38",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:21302490",
"relation": "IDG (Drug Target)",
"target": "1813",
"properties": {
"id": "lumateperone targets DRD2",
"source_label": "lumateperone",
"target_label": "DRD2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.49",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:21302490",
"relation": "IDG (Drug Target)",
"target": "1815",
"properties": {
"id": "lumateperone targets DRD4",
"source_label": "lumateperone",
"target_label": "DRD4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.97",
"act_comment": "Inhibition of human dopamine D4 receptor",
"act_source": "CHEMBL"
}
},
{
"source": "CID:21302490",
"relation": "IDG (Drug Target)",
"target": "3356",
"properties": {
"id": "lumateperone targets HTR2A",
"source_label": "lumateperone",
"target_label": "HTR2A",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.26",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:21302490",
"relation": "IDG (Drug Target)",
"target": "3358",
"properties": {
"id": "lumateperone targets HTR2C",
"source_label": "lumateperone",
"target_label": "HTR2C",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.76",
"act_comment": "Displacement of [125]DOI from human recombinant full length 5HT2C receptor expressed in HEK293E cells",
"act_source": "CHEMBL"
}
},
{
"source": "CID:21302490",
"relation": "IDG (Drug Target)",
"target": "6532",
"properties": {
"id": "lumateperone targets SLC6A4",
"source_label": "lumateperone",
"target_label": "SLC6A4",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.48",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:6000538",
"relation": "IDG (Drug Target)",
"target": "5027",
"properties": {
"id": "brilliant Blue G targets P2RX7",
"source_label": "brilliant Blue G",
"target_label": "P2RX7",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:56944144",
"relation": "IDG (Drug Target)",
"target": "3061",
"properties": {
"id": "lemborexant targets HCRTR1",
"source_label": "lemborexant",
"target_label": "HCRTR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:56944144",
"relation": "IDG (Drug Target)",
"target": "3062",
"properties": {
"id": "lemborexant targets HCRTR2",
"source_label": "lemborexant",
"target_label": "HCRTR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:68748835",
"relation": "IDG (Drug Target)",
"target": "10203",
"properties": {
"id": "ubrogepant targets CALCRL",
"source_label": "ubrogepant",
"target_label": "CALCRL",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.2",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:134587348",
"relation": "IDG (Drug Target)",
"target": "1080",
"properties": {
"id": "elexacaftor targets CFTR",
"source_label": "elexacaftor",
"target_label": "CFTR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.15",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:71488522",
"relation": "IDG (Drug Target)",
"target": "142",
"properties": {
"id": "mefuparib targets PARP1",
"source_label": "mefuparib",
"target_label": "PARP1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.49",
"act_comment": "biotinylated [NAD+]-based luminescence assays",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71488522",
"relation": "IDG (Drug Target)",
"target": "10038",
"properties": {
"id": "mefuparib targets PARP2",
"source_label": "mefuparib",
"target_label": "PARP2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.72",
"act_comment": "biotinylated [NAD+]-based luminescence assays",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:118023034",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "avapritinib targets KIT",
"source_label": "avapritinib",
"target_label": "KIT",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.57",
"act_comment": "KIT D816V (exon 17)",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:118023034",
"relation": "IDG (Drug Target)",
"target": "5156",
"properties": {
"id": "avapritinib targets PDGFRA",
"source_label": "avapritinib",
"target_label": "PDGFRA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.62",
"act_comment": "PDGFRA D842V (exon 18) mutant",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:66558664",
"relation": "IDG (Drug Target)",
"target": "8726",
"properties": {
"id": "tazemetostat targets EED",
"source_label": "tazemetostat",
"target_label": "EED",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "Inhibition of recombinant N-terminal GST-tagged EED (76 to 441 residues) (unknown origin) expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL assessed as reduction in SAH production using H3[21-44,K27Me0) peptide as substrate measured after 20 mins by LC/MS/MS method",
"act_source": "CHEMBL"
}
},
{
"source": "CID:66558664",
"relation": "IDG (Drug Target)",
"target": "2145",
"properties": {
"id": "tazemetostat targets EZH1",
"source_label": "tazemetostat",
"target_label": "EZH1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.41",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:66558664",
"relation": "IDG (Drug Target)",
"target": "2146",
"properties": {
"id": "tazemetostat targets EZH2",
"source_label": "tazemetostat",
"target_label": "EZH2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "Mechanism of Action",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:51049968",
"relation": "IDG (Drug Target)",
"target": "10203",
"properties": {
"id": "rimegepant targets CALCRL",
"source_label": "rimegepant",
"target_label": "CALCRL",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.56",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:52938427",
"relation": "IDG (Drug Target)",
"target": "1901",
"properties": {
"id": "ozanimod targets S1PR1",
"source_label": "ozanimod",
"target_label": "S1PR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "9.39",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:52938427",
"relation": "IDG (Drug Target)",
"target": "53637",
"properties": {
"id": "ozanimod targets S1PR5",
"source_label": "ozanimod",
"target_label": "S1PR5",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44139752",
"relation": "IDG (Drug Target)",
"target": "1584",
"properties": {
"id": "osilodrostat targets CYP11B1",
"source_label": "osilodrostat",
"target_label": "CYP11B1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.6",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:44139752",
"relation": "IDG (Drug Target)",
"target": "1585",
"properties": {
"id": "osilodrostat targets CYP11B2",
"source_label": "osilodrostat",
"target_label": "CYP11B2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.15",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:44139752",
"relation": "IDG (Drug Target)",
"target": "1588",
"properties": {
"id": "osilodrostat targets CYP19A1",
"source_label": "osilodrostat",
"target_label": "CYP19A1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.07",
"act_comment": "Inhibition of CYP19 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10127622",
"relation": "IDG (Drug Target)",
"target": "5604",
"properties": {
"id": "selumetinib targets MAP2K1",
"source_label": "selumetinib",
"target_label": "MAP2K1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:10127622",
"relation": "IDG (Drug Target)",
"target": "5605",
"properties": {
"id": "selumetinib targets MAP2K2",
"source_label": "selumetinib",
"target_label": "MAP2K2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.85",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:10127622",
"relation": "IDG (Drug Target)",
"target": "8243",
"properties": {
"id": "selumetinib targets SMC1A",
"source_label": "selumetinib",
"target_label": "SMC1A",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.44",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10127622",
"relation": "IDG (Drug Target)",
"target": "10592",
"properties": {
"id": "selumetinib targets SMC2",
"source_label": "selumetinib",
"target_label": "SMC2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.68",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:51039094",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "tucatinib targets EGFR",
"source_label": "tucatinib",
"target_label": "EGFR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Inhibition of enzyme activity in a biochemical assay.",
"act_source": "IUPHAR"
}
},
{
"source": "CID:51039094",
"relation": "IDG (Drug Target)",
"target": "2066",
"properties": {
"id": "tucatinib targets ERBB4",
"source_label": "tucatinib",
"target_label": "ERBB4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.5",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:51039094",
"relation": "IDG (Drug Target)",
"target": "79784",
"properties": {
"id": "tucatinib targets MYH14",
"source_label": "tucatinib",
"target_label": "MYH14",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.73",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:86705695",
"relation": "IDG (Drug Target)",
"target": "2260",
"properties": {
"id": "pemigatinib targets FGFR1",
"source_label": "pemigatinib",
"target_label": "FGFR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:86705695",
"relation": "IDG (Drug Target)",
"target": "2263",
"properties": {
"id": "pemigatinib targets FGFR2",
"source_label": "pemigatinib",
"target_label": "FGFR2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.3",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:86705695",
"relation": "IDG (Drug Target)",
"target": "2261",
"properties": {
"id": "pemigatinib targets FGFR3",
"source_label": "pemigatinib",
"target_label": "FGFR3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:86705695",
"relation": "IDG (Drug Target)",
"target": "2264",
"properties": {
"id": "pemigatinib targets FGFR4",
"source_label": "pemigatinib",
"target_label": "FGFR4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.52",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:25145656",
"relation": "IDG (Drug Target)",
"target": "4233",
"properties": {
"id": "capmatinib targets MET",
"source_label": "capmatinib",
"target_label": "MET",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.88",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:134436906",
"relation": "IDG (Drug Target)",
"target": "9212",
"properties": {
"id": "selpercatinib targets AURKB",
"source_label": "selpercatinib",
"target_label": "AURKB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.1",
"act_comment": "In vitro kinase profiling assays",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:134436906",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "selpercatinib targets RET",
"source_label": "selpercatinib",
"target_label": "RET",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.76",
"act_comment": "In vitro kinase profiling assays",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:71584930",
"relation": "IDG (Drug Target)",
"target": "1436",
"properties": {
"id": "ripretinib targets CSF1R",
"source_label": "ripretinib",
"target_label": "CSF1R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.91",
"act_comment": "In vitro kinase binding assay",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:71584930",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "ripretinib targets KDR",
"source_label": "ripretinib",
"target_label": "KDR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.47",
"act_comment": "In vitro kinase binding assay",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:71584930",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "ripretinib targets KIT",
"source_label": "ripretinib",
"target_label": "KIT",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.52",
"act_comment": "Wild type kinase",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71584930",
"relation": "IDG (Drug Target)",
"target": "5156",
"properties": {
"id": "ripretinib targets PDGFRA",
"source_label": "ripretinib",
"target_label": "PDGFRA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.44",
"act_comment": "Wild type kinase",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:71584930",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "ripretinib targets PDGFRB",
"source_label": "ripretinib",
"target_label": "PDGFRB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "In vitro kinase binding assay",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:71584930",
"relation": "IDG (Drug Target)",
"target": "7010",
"properties": {
"id": "ripretinib targets TEK",
"source_label": "ripretinib",
"target_label": "TEK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.27",
"act_comment": "In vitro kinase binding assay",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:10869981",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "fluoroestradiol F 18 targets ESR1",
"source_label": "fluoroestradiol F 18",
"target_label": "ESR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.07",
"act_comment": "Activity determined in an ER-positive human breast cancer cell line",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:70957463",
"relation": "IDG (Drug Target)",
"target": "4137",
"properties": {
"id": "flortaucipir F 18 targets MAPT",
"source_label": "flortaucipir F 18",
"target_label": "MAPT",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.24",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:25267009",
"relation": "IDG (Drug Target)",
"target": "978",
"properties": {
"id": "inqovi targets CDA",
"source_label": "inqovi",
"target_label": "CDA",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.39",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:66553195",
"relation": "IDG (Drug Target)",
"target": "4987",
"properties": {
"id": "oliceridine targets OPRL1",
"source_label": "oliceridine",
"target_label": "OPRL1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.4",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:66553195",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "oliceridine targets OPRM1",
"source_label": "oliceridine",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "Mechanism of Action",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:11750009",
"relation": "IDG (Drug Target)",
"target": "367",
"properties": {
"id": "clascoterone targets AR",
"source_label": "clascoterone",
"target_label": "AR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "Activity measured in LNCaP cells",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:124220636",
"relation": "IDG (Drug Target)",
"target": "6752",
"properties": {
"id": "copper dotatate Cu-64 targets SSTR2",
"source_label": "copper dotatate Cu-64",
"target_label": "SSTR2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.69",
"act_comment": "Activity determined in human embryonic kidney HEK-293 cell line stably expressing human sst2 receptors",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:137699276",
"relation": "IDG (Drug Target)",
"target": "780",
"properties": {
"id": "pralsetinib targets DDR1",
"source_label": "pralsetinib",
"target_label": "DDR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:137699276",
"relation": "IDG (Drug Target)",
"target": "2260",
"properties": {
"id": "pralsetinib targets FGFR1",
"source_label": "pralsetinib",
"target_label": "FGFR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.96",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:137699276",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "pralsetinib targets FLT3",
"source_label": "pralsetinib",
"target_label": "FLT3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:137699276",
"relation": "IDG (Drug Target)",
"target": "3716",
"properties": {
"id": "pralsetinib targets JAK1",
"source_label": "pralsetinib",
"target_label": "JAK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.66",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:137699276",
"relation": "IDG (Drug Target)",
"target": "3717",
"properties": {
"id": "pralsetinib targets JAK2",
"source_label": "pralsetinib",
"target_label": "JAK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:137699276",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "pralsetinib targets KDR",
"source_label": "pralsetinib",
"target_label": "KDR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.46",
"act_comment": "Biochemical assay",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:137699276",
"relation": "IDG (Drug Target)",
"target": "4914",
"properties": {
"id": "pralsetinib targets NTRK1",
"source_label": "pralsetinib",
"target_label": "NTRK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.24",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:137699276",
"relation": "IDG (Drug Target)",
"target": "4916",
"properties": {
"id": "pralsetinib targets NTRK3",
"source_label": "pralsetinib",
"target_label": "NTRK3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.05",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:137699276",
"relation": "IDG (Drug Target)",
"target": "5159",
"properties": {
"id": "pralsetinib targets PDGFRB",
"source_label": "pralsetinib",
"target_label": "PDGFRB",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:137699276",
"relation": "IDG (Drug Target)",
"target": "5979",
"properties": {
"id": "pralsetinib targets RET",
"source_label": "pralsetinib",
"target_label": "RET",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.39",
"act_comment": "Similar activity values for CCDC6-RET and the following RET mutations: M918T, V804L, V804M",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:148195",
"relation": "IDG (Drug Target)",
"target": "3265",
"properties": {
"id": "lonafarnib targets HRAS",
"source_label": "lonafarnib",
"target_label": "HRAS",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.72",
"act_comment": "Measuring inhibition of farnesylation of HRAS by human farnesyltransferase",
"act_source": "IUPHAR"
}
},
{
"source": "CID:148195",
"relation": "IDG (Drug Target)",
"target": "3845",
"properties": {
"id": "lonafarnib targets KRAS",
"source_label": "lonafarnib",
"target_label": "KRAS",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.28",
"act_comment": "Measuring inhibition of farnesylation of KRAS4B by human farnesyltransferase",
"act_source": "IUPHAR"
}
},
{
"source": "CID:148195",
"relation": "IDG (Drug Target)",
"target": "4893",
"properties": {
"id": "lonafarnib targets NRAS",
"source_label": "lonafarnib",
"target_label": "NRAS",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.55",
"act_comment": "Measuring inhibition of farnesylation of NRAS by human farnesyltransferase",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11993702",
"relation": "IDG (Drug Target)",
"target": "4157",
"properties": {
"id": "setmelanotide targets MC1R",
"source_label": "setmelanotide",
"target_label": "MC1R",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.41",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11993702",
"relation": "IDG (Drug Target)",
"target": "4159",
"properties": {
"id": "setmelanotide targets MC3R",
"source_label": "setmelanotide",
"target_label": "MC3R",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:11993702",
"relation": "IDG (Drug Target)",
"target": "4160",
"properties": {
"id": "setmelanotide targets MC4R",
"source_label": "setmelanotide",
"target_label": "MC4R",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.68",
"act_comment": "Mechanism of Action",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:11993702",
"relation": "IDG (Drug Target)",
"target": "4161",
"properties": {
"id": "setmelanotide targets MC5R",
"source_label": "setmelanotide",
"target_label": "MC5R",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.37",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:49831257",
"relation": "IDG (Drug Target)",
"target": "1436",
"properties": {
"id": "filgotinib targets CSF1R",
"source_label": "filgotinib",
"target_label": "CSF1R",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.31",
"act_comment": "Inhibition of human CSF1R (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49831257",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "filgotinib targets FLT3",
"source_label": "filgotinib",
"target_label": "FLT3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.47",
"act_comment": "Inhibition of human FLT3 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49831257",
"relation": "IDG (Drug Target)",
"target": "2324",
"properties": {
"id": "filgotinib targets FLT4",
"source_label": "filgotinib",
"target_label": "FLT4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.56",
"act_comment": "Inhibition of human FLT4 (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:49831257",
"relation": "IDG (Drug Target)",
"target": "3716",
"properties": {
"id": "filgotinib targets JAK1",
"source_label": "filgotinib",
"target_label": "JAK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:49831257",
"relation": "IDG (Drug Target)",
"target": "3717",
"properties": {
"id": "filgotinib targets JAK2",
"source_label": "filgotinib",
"target_label": "JAK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.55",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:49831257",
"relation": "IDG (Drug Target)",
"target": "3718",
"properties": {
"id": "filgotinib targets JAK3",
"source_label": "filgotinib",
"target_label": "JAK3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.09",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:49831257",
"relation": "IDG (Drug Target)",
"target": "7297",
"properties": {
"id": "filgotinib targets TYK2",
"source_label": "filgotinib",
"target_label": "TYK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.94",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:23634441",
"relation": "IDG (Drug Target)",
"target": "54583",
"properties": {
"id": "vadadustat targets EGLN1",
"source_label": "vadadustat",
"target_label": "EGLN1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.81",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:23634441",
"relation": "IDG (Drug Target)",
"target": "112398",
"properties": {
"id": "vadadustat targets EGLN2",
"source_label": "vadadustat",
"target_label": "EGLN2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.93",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:23634441",
"relation": "IDG (Drug Target)",
"target": "112399",
"properties": {
"id": "vadadustat targets EGLN3",
"source_label": "vadadustat",
"target_label": "EGLN3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.12",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:91617630",
"relation": "IDG (Drug Target)",
"target": "54583",
"properties": {
"id": "daprodustat targets EGLN1",
"source_label": "daprodustat",
"target_label": "EGLN1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.46",
"act_comment": "FRET assay developed to measure human PHD enzymatic activity using as substrate HIF1alpha CODDD",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:91617630",
"relation": "IDG (Drug Target)",
"target": "112398",
"properties": {
"id": "daprodustat targets EGLN2",
"source_label": "daprodustat",
"target_label": "EGLN2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.14",
"act_comment": "FRET assay developed to measure human PHD enzymatic activity using as substrate HIF1alpha CODDD",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:91617630",
"relation": "IDG (Drug Target)",
"target": "112399",
"properties": {
"id": "daprodustat targets EGLN3",
"source_label": "daprodustat",
"target_label": "EGLN3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.26",
"act_comment": "FRET assay developed to measure human PHD enzymatic activity using as substrate HIF2alpha CODDD",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:54755438",
"relation": "IDG (Drug Target)",
"target": "640",
"properties": {
"id": "tirabrutinib hydrochloride targets BLK",
"source_label": "tirabrutinib hydrochloride",
"target_label": "BLK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:54755438",
"relation": "IDG (Drug Target)",
"target": "660",
"properties": {
"id": "tirabrutinib hydrochloride targets BMX",
"source_label": "tirabrutinib hydrochloride",
"target_label": "BMX",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.22",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:54755438",
"relation": "IDG (Drug Target)",
"target": "695",
"properties": {
"id": "tirabrutinib hydrochloride targets BTK",
"source_label": "tirabrutinib hydrochloride",
"target_label": "BTK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.17",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:54755438",
"relation": "IDG (Drug Target)",
"target": "2064",
"properties": {
"id": "tirabrutinib hydrochloride targets ERBB2",
"source_label": "tirabrutinib hydrochloride",
"target_label": "ERBB2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Binding affinity to DNA-tagged recombinant ERBB2 (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysis",
"act_source": "CHEMBL"
}
},
{
"source": "CID:54755438",
"relation": "IDG (Drug Target)",
"target": "2066",
"properties": {
"id": "tirabrutinib hydrochloride targets ERBB4",
"source_label": "tirabrutinib hydrochloride",
"target_label": "ERBB4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.11",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:54755438",
"relation": "IDG (Drug Target)",
"target": "3932",
"properties": {
"id": "tirabrutinib hydrochloride targets LCK",
"source_label": "tirabrutinib hydrochloride",
"target_label": "LCK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.43",
"act_comment": "Z'-LYTE Kinase Assay: The measurement of Btk enzyme inhibitory activity was performed using the following reagents: Z'-LYTE Kinase Assay Kit-Tyr 1 (containing Tyr 1 peptide, Thy 1 phospho-peptide, 5x kinase buffer, ATP, development reagent B, development buffer, and stop reagent), Tyr 1 peptide (Invitrogen), and Btk (Invitrogen) according to the instructions accompanying the kit.First 5 uL/well of either a solution prepared by diluting the test compound in dimethyl sulfoxide (DMSO) or DMSO alone was added to the wells of a 96-well assay plate together with 10 uL/well of substrate/enzyme mixture and allowed to react for 20 minutes at 30\u00c2\u00b0 C. The substrate/enzyme mixture solutions were prepared by dilution in kinase buffer (DL-dithiothreitol (DTT; 2.7 mM) and 1.33x kinase buffer) so that the final concentration of Tyr-1 peptide would be 4 uM, and the final concentration of Btk would be 5 nM. Next 5 uL/well of adenosine triphosphate was added (ATP; final concentration 36 uM).",
"act_source": "CHEMBL"
}
},
{
"source": "CID:54755438",
"relation": "IDG (Drug Target)",
"target": "7006",
"properties": {
"id": "tirabrutinib hydrochloride targets TEC",
"source_label": "tirabrutinib hydrochloride",
"target_label": "TEC",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.32",
"act_comment": "Inhibition of TEC was determined using LanthaScreen binding assay",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:54755438",
"relation": "IDG (Drug Target)",
"target": "7294",
"properties": {
"id": "tirabrutinib hydrochloride targets TXK",
"source_label": "tirabrutinib hydrochloride",
"target_label": "TXK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.04",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:25171648",
"relation": "IDG (Drug Target)",
"target": "51135",
"properties": {
"id": "tepotinib targets IRAK4",
"source_label": "tepotinib",
"target_label": "IRAK4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.21",
"act_comment": "Kinase profiling assay",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:25171648",
"relation": "IDG (Drug Target)",
"target": "4233",
"properties": {
"id": "tepotinib targets MET",
"source_label": "tepotinib",
"target_label": "MET",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.77",
"act_comment": "Inhibition of c-Met phosphorylation and downstream signaling pathways (MoA)",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:25171648",
"relation": "IDG (Drug Target)",
"target": "4835",
"properties": {
"id": "tepotinib targets NQO2",
"source_label": "tepotinib",
"target_label": "NQO2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.06",
"act_comment": "Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.",
"act_source": "CHEMBL"
}
},
{
"source": "CID:51349053",
"relation": "IDG (Drug Target)",
"target": "116085",
"properties": {
"id": "dotinurad targets SLC22A12",
"source_label": "dotinurad",
"target_label": "SLC22A12",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.43",
"act_comment": "MoA - URAT1-overexpressing MDCKII cell",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:50914062",
"relation": "IDG (Drug Target)",
"target": "3716",
"properties": {
"id": "delgocitinib targets JAK1",
"source_label": "delgocitinib",
"target_label": "JAK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.55",
"act_comment": "ATP concentration at the Km specific for JAK1 of 40 \u00ce\u00bcM",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:50914062",
"relation": "IDG (Drug Target)",
"target": "3717",
"properties": {
"id": "delgocitinib targets JAK2",
"source_label": "delgocitinib",
"target_label": "JAK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.58",
"act_comment": "ATP concentration at the Km specific for JAK2 of 10 \u00ce\u00bcM",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:50914062",
"relation": "IDG (Drug Target)",
"target": "3718",
"properties": {
"id": "delgocitinib targets JAK3",
"source_label": "delgocitinib",
"target_label": "JAK3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.89",
"act_comment": "ATP concentration at the Km specific for JAK3 of 2.5 \u00ce\u00bcM",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:50914062",
"relation": "IDG (Drug Target)",
"target": "9475",
"properties": {
"id": "delgocitinib targets ROCK2",
"source_label": "delgocitinib",
"target_label": "ROCK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.58",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:50914062",
"relation": "IDG (Drug Target)",
"target": "7297",
"properties": {
"id": "delgocitinib targets TYK2",
"source_label": "delgocitinib",
"target_label": "TYK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.24",
"act_comment": "ATP concentration at the Km specific for Tyk2 of 40 \u00ce\u00bcM",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:164512666",
"relation": "IDG (Drug Target)",
"target": "54583",
"properties": {
"id": "enarodustat targets EGLN1",
"source_label": "enarodustat",
"target_label": "EGLN1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "Competitive inhibition, substrate 2-oxoglutarate",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:164512666",
"relation": "IDG (Drug Target)",
"target": "112398",
"properties": {
"id": "enarodustat targets EGLN2",
"source_label": "enarodustat",
"target_label": "EGLN2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.21",
"act_comment": "Competitive inhibition, substrate 2-oxoglutarate",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:164512666",
"relation": "IDG (Drug Target)",
"target": "112399",
"properties": {
"id": "enarodustat targets EGLN3",
"source_label": "enarodustat",
"target_label": "EGLN3",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Competitive inhibition, substrate 2-oxoglutarate",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:154572876",
"relation": "IDG (Drug Target)",
"target": "354",
"properties": {
"id": "gallium (68Ga) gozetotide targets KLK3",
"source_label": "gallium (68Ga) gozetotide",
"target_label": "KLK3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.57",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:137528262",
"relation": "IDG (Drug Target)",
"target": "3818",
"properties": {
"id": "berotralstat targets KLKB1",
"source_label": "berotralstat",
"target_label": "KLKB1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.8",
"act_comment": "Activity determined against plasma kallikrein from patients with HAE",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:23635314",
"relation": "IDG (Drug Target)",
"target": "4067",
"properties": {
"id": "tirbanibulin targets LYN",
"source_label": "tirbanibulin",
"target_label": "LYN",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.0",
"act_comment": "Inhibition of LYN (unknown origin)",
"act_source": "CHEMBL"
}
},
{
"source": "CID:10348973",
"relation": "IDG (Drug Target)",
"target": "2798",
"properties": {
"id": "relugolix targets GNRHR",
"source_label": "relugolix",
"target_label": "GNRHR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.92",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:72950888",
"relation": "IDG (Drug Target)",
"target": "1454",
"properties": {
"id": "umbralisib targets CSNK1E",
"source_label": "umbralisib",
"target_label": "CSNK1E",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:72950888",
"relation": "IDG (Drug Target)",
"target": "5293",
"properties": {
"id": "umbralisib targets PIK3CD",
"source_label": "umbralisib",
"target_label": "PIK3CD",
"act_type": "Kd",
"act_relation": "=",
"act_value": "8.21",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:68029831",
"relation": "IDG (Drug Target)",
"target": "1019",
"properties": {
"id": "trilaciclib targets CDK4",
"source_label": "trilaciclib",
"target_label": "CDK4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "Mechanism of Action",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:68029831",
"relation": "IDG (Drug Target)",
"target": "1021",
"properties": {
"id": "trilaciclib targets CDK6",
"source_label": "trilaciclib",
"target_label": "CDK6",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.4",
"act_comment": "Mechanism of Action",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:68029831",
"relation": "IDG (Drug Target)",
"target": "1025",
"properties": {
"id": "trilaciclib targets CDK9",
"source_label": "trilaciclib",
"target_label": "CDK9",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.3",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:68029831",
"relation": "IDG (Drug Target)",
"target": "2322",
"properties": {
"id": "trilaciclib targets FLT3",
"source_label": "trilaciclib",
"target_label": "FLT3",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.15",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:68029831",
"relation": "IDG (Drug Target)",
"target": "152110",
"properties": {
"id": "trilaciclib targets NEK10",
"source_label": "trilaciclib",
"target_label": "NEK10",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.57",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:68029831",
"relation": "IDG (Drug Target)",
"target": "81788",
"properties": {
"id": "trilaciclib targets NUAK2",
"source_label": "trilaciclib",
"target_label": "NUAK2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "9.15",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:11363176",
"relation": "IDG (Drug Target)",
"target": "1901",
"properties": {
"id": "ponesimod targets S1PR1",
"source_label": "ponesimod",
"target_label": "S1PR1",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.13",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11363176",
"relation": "IDG (Drug Target)",
"target": "1903",
"properties": {
"id": "ponesimod targets S1PR3",
"source_label": "ponesimod",
"target_label": "S1PR3",
"act_type": "EC50",
"act_relation": "=",
"act_value": "6.94",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:11363176",
"relation": "IDG (Drug Target)",
"target": "53637",
"properties": {
"id": "ponesimod targets S1PR5",
"source_label": "ponesimod",
"target_label": "S1PR5",
"act_type": "EC50",
"act_relation": "=",
"act_value": "7.23",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:164512667",
"relation": "IDG (Drug Target)",
"target": "2642",
"properties": {
"id": "dasiglucagon targets GCGR",
"source_label": "dasiglucagon",
"target_label": "GCGR",
"act_type": "EC50",
"act_relation": "=",
"act_value": "11.0",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:27125",
"relation": "IDG (Drug Target)",
"target": "2099",
"properties": {
"id": "estetrol targets ESR1",
"source_label": "estetrol",
"target_label": "ESR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.31",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:27125",
"relation": "IDG (Drug Target)",
"target": "2100",
"properties": {
"id": "estetrol targets ESR2",
"source_label": "estetrol",
"target_label": "ESR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.72",
"act_comment": "Mechanism of Action",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:53235510",
"relation": "IDG (Drug Target)",
"target": "2260",
"properties": {
"id": "infigratinib targets FGFR1",
"source_label": "infigratinib",
"target_label": "FGFR1",
"act_type": "nan",
"act_relation": "=",
"act_value": "8.99",
"act_comment": "Mechanism of Action",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:53235510",
"relation": "IDG (Drug Target)",
"target": "2263",
"properties": {
"id": "infigratinib targets FGFR2",
"source_label": "infigratinib",
"target_label": "FGFR2",
"act_type": "nan",
"act_relation": "=",
"act_value": "9.0",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:53235510",
"relation": "IDG (Drug Target)",
"target": "2261",
"properties": {
"id": "infigratinib targets FGFR3",
"source_label": "infigratinib",
"target_label": "FGFR3",
"act_type": "nan",
"act_relation": "=",
"act_value": "8.7",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:53235510",
"relation": "IDG (Drug Target)",
"target": "2264",
"properties": {
"id": "infigratinib targets FGFR4",
"source_label": "infigratinib",
"target_label": "FGFR4",
"act_type": "nan",
"act_relation": "=",
"act_value": "7.21",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:53235510",
"relation": "IDG (Drug Target)",
"target": "3791",
"properties": {
"id": "infigratinib targets KDR",
"source_label": "infigratinib",
"target_label": "KDR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:53235510",
"relation": "IDG (Drug Target)",
"target": "3815",
"properties": {
"id": "infigratinib targets KIT",
"source_label": "infigratinib",
"target_label": "KIT",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.12",
"act_comment": "Inhibition of recombinant KIT kinase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:53235510",
"relation": "IDG (Drug Target)",
"target": "4067",
"properties": {
"id": "infigratinib targets LYN",
"source_label": "infigratinib",
"target_label": "LYN",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.52",
"act_comment": "Inhibition of recombinant LYN kinase",
"act_source": "CHEMBL"
}
},
{
"source": "CID:53235510",
"relation": "IDG (Drug Target)",
"target": "6608",
"properties": {
"id": "infigratinib targets SMO",
"source_label": "infigratinib",
"target_label": "SMO",
"act_type": "Ki",
"act_relation": "=",
"act_value": "7.33",
"act_comment": "Displacement of [3H]-cyclopamine from SMO V404M mutant in gefitinib resistant human HCC827 cells by scintillation counting",
"act_source": "CHEMBL"
}
},
{
"source": "CID:11624889",
"relation": "IDG (Drug Target)",
"target": "4985",
"properties": {
"id": "samidorphan targets OPRD1",
"source_label": "samidorphan",
"target_label": "OPRD1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "8.59",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:11624889",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "samidorphan targets OPRK1",
"source_label": "samidorphan",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.64",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:11624889",
"relation": "IDG (Drug Target)",
"target": "4988",
"properties": {
"id": "samidorphan targets OPRM1",
"source_label": "samidorphan",
"target_label": "OPRM1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.28",
"act_comment": "Possible target for the mechanism of action of the drug",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:138461166",
"relation": "IDG (Drug Target)",
"target": "3845",
"properties": {
"id": "sotorasib targets KRAS",
"source_label": "sotorasib",
"target_label": "KRAS",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.03",
"act_comment": "KRAS G12C mutation",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:60150535",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "finerenone targets NR3C2",
"source_label": "finerenone",
"target_label": "NR3C2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.77",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:10153627",
"relation": "IDG (Drug Target)",
"target": "6555",
"properties": {
"id": "odevixibat targets SLC10A2",
"source_label": "odevixibat",
"target_label": "SLC10A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.89",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:117947097",
"relation": "IDG (Drug Target)",
"target": "2034",
"properties": {
"id": "belzutifan targets EPAS1",
"source_label": "belzutifan",
"target_label": "EPAS1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.0",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:24794466",
"relation": "IDG (Drug Target)",
"target": "4986",
"properties": {
"id": "difelikefalin targets OPRK1",
"source_label": "difelikefalin",
"target_label": "OPRK1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.49",
"act_comment": "nan",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:118607832",
"relation": "IDG (Drug Target)",
"target": "640",
"properties": {
"id": "mobocertinib targets BLK",
"source_label": "mobocertinib",
"target_label": "BLK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.7",
"act_comment": "In vitro kinase screen at multiple concentrations of the compound",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:118607832",
"relation": "IDG (Drug Target)",
"target": "695",
"properties": {
"id": "mobocertinib targets BTK",
"source_label": "mobocertinib",
"target_label": "BTK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.55",
"act_comment": "In vitro kinase screen at multiple concentrations of the compound",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:118607832",
"relation": "IDG (Drug Target)",
"target": "1956",
"properties": {
"id": "mobocertinib targets EGFR",
"source_label": "mobocertinib",
"target_label": "EGFR",
"act_type": "Kd",
"act_relation": "=",
"act_value": "6.67",
"act_comment": "The binding was assessed to the EGFR exon 20 D770_N771insNPG (Exon 20 NPG EGFR) insertion mutant.",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:118607832",
"relation": "IDG (Drug Target)",
"target": "2064",
"properties": {
"id": "mobocertinib targets ERBB2",
"source_label": "mobocertinib",
"target_label": "ERBB2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.4",
"act_comment": "In vitro kinase screen at multiple concentrations of the compound",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:118607832",
"relation": "IDG (Drug Target)",
"target": "2066",
"properties": {
"id": "mobocertinib targets ERBB4",
"source_label": "mobocertinib",
"target_label": "ERBB4",
"act_type": "IC50",
"act_relation": "=",
"act_value": "10.0",
"act_comment": "In vitro kinase screen at multiple concentrations of the compound",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:118607832",
"relation": "IDG (Drug Target)",
"target": "3718",
"properties": {
"id": "mobocertinib targets JAK3",
"source_label": "mobocertinib",
"target_label": "JAK3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.66",
"act_comment": "In vitro kinase screen at multiple concentrations of the compound",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:118607832",
"relation": "IDG (Drug Target)",
"target": "7294",
"properties": {
"id": "mobocertinib targets TXK",
"source_label": "mobocertinib",
"target_label": "TXK",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.64",
"act_comment": "In vitro kinase screen at multiple concentrations of the compound",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:72163100",
"relation": "IDG (Drug Target)",
"target": "10203",
"properties": {
"id": "atogepant targets CALCRL",
"source_label": "atogepant",
"target_label": "CALCRL",
"act_type": "Ki",
"act_relation": "=",
"act_value": "10.82",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9831643",
"relation": "IDG (Drug Target)",
"target": "6555",
"properties": {
"id": "maralixibat hydrochloride targets SLC10A2",
"source_label": "maralixibat hydrochloride",
"target_label": "SLC10A2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.55",
"act_comment": "In vitro inhibition in baby hamster cells expressing human IBAT.",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:119058036",
"relation": "IDG (Drug Target)",
"target": "4882",
"properties": {
"id": "vosoritide targets NPR2",
"source_label": "vosoritide",
"target_label": "NPR2",
"act_type": "EC50",
"act_relation": "=",
"act_value": "8.77",
"act_comment": "The receptor NPR-B from rabbit, rat, mouse and human was expressed in HEK cells (HEK293T cells).",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:57928403",
"relation": "IDG (Drug Target)",
"target": "3716",
"properties": {
"id": "peficitinib targets JAK1",
"source_label": "peficitinib",
"target_label": "JAK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.41",
"act_comment": "Recombinant human kinases assay",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:57928403",
"relation": "IDG (Drug Target)",
"target": "3717",
"properties": {
"id": "peficitinib targets JAK2",
"source_label": "peficitinib",
"target_label": "JAK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.3",
"act_comment": "Recombinant human kinases assay",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:57928403",
"relation": "IDG (Drug Target)",
"target": "3718",
"properties": {
"id": "peficitinib targets JAK3",
"source_label": "peficitinib",
"target_label": "JAK3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.15",
"act_comment": "Recombinant human kinases assay",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:57928403",
"relation": "IDG (Drug Target)",
"target": "7297",
"properties": {
"id": "peficitinib targets TYK2",
"source_label": "peficitinib",
"target_label": "TYK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.32",
"act_comment": "Recombinant human kinases assay",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:59603622",
"relation": "IDG (Drug Target)",
"target": "54583",
"properties": {
"id": "molidustat targets EGLN1",
"source_label": "molidustat",
"target_label": "EGLN1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.55",
"act_comment": "Assay conditions: 20 microM 2-oxoglutarate, 10 microM Fe2+, and 2 mM ascorbate",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:59603622",
"relation": "IDG (Drug Target)",
"target": "112398",
"properties": {
"id": "molidustat targets EGLN2",
"source_label": "molidustat",
"target_label": "EGLN2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.32",
"act_comment": "Assay conditions: 20 microM 2-oxoglutarate, 10 microM Fe2+, and 2 mM ascorbate",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:59603622",
"relation": "IDG (Drug Target)",
"target": "112399",
"properties": {
"id": "molidustat targets EGLN3",
"source_label": "molidustat",
"target_label": "EGLN3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.35",
"act_comment": "Assay conditions: 20 microM 2-oxoglutarate, 10 microM Fe2+, and 2 mM ascorbate",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:9828911",
"relation": "IDG (Drug Target)",
"target": "2693",
"properties": {
"id": "anamorelin targets GHSR",
"source_label": "anamorelin",
"target_label": "GHSR",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.14",
"act_comment": "Anamorelin competitively inhibited the binding of human ghrelin to GHS-R1a",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:25052023",
"relation": "IDG (Drug Target)",
"target": "4306",
"properties": {
"id": "esaxerenone targets NR3C2",
"source_label": "esaxerenone",
"target_label": "NR3C2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.43",
"act_comment": "Antagonist effects on the transcriptional activity",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:59509752",
"relation": "IDG (Drug Target)",
"target": "781",
"properties": {
"id": "mirogabalin targets CACNA2D1",
"source_label": "mirogabalin",
"target_label": "CACNA2D1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.87",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:59509752",
"relation": "IDG (Drug Target)",
"target": "9254",
"properties": {
"id": "mirogabalin targets CACNA2D2",
"source_label": "mirogabalin",
"target_label": "CACNA2D2",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.64",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:91801202",
"relation": "IDG (Drug Target)",
"target": "3061",
"properties": {
"id": "daridorexant targets HCRTR1",
"source_label": "daridorexant",
"target_label": "HCRTR1",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.33",
"act_comment": "Possible mechanism of action",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:91801202",
"relation": "IDG (Drug Target)",
"target": "3062",
"properties": {
"id": "daridorexant targets HCRTR2",
"source_label": "daridorexant",
"target_label": "HCRTR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "9.03",
"act_comment": "Possible mechanism of action",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:49841217",
"relation": "IDG (Drug Target)",
"target": "728",
"properties": {
"id": "avacopan targets C5AR1",
"source_label": "avacopan",
"target_label": "C5AR1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "9.35",
"act_comment": "CCX168 was evaluated for its ability to displace 125I-human C5a from the C5a receptor on human U937 cells",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:72165228",
"relation": "IDG (Drug Target)",
"target": "25",
"properties": {
"id": "asciminib targets ABL1",
"source_label": "asciminib",
"target_label": "ABL1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "8.59",
"act_comment": "Radiometric filter binding assay",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:164512668",
"relation": "IDG (Drug Target)",
"target": "2348",
"properties": {
"id": "pafolacianine targets FOLR1",
"source_label": "pafolacianine",
"target_label": "FOLR1",
"act_type": "Kd",
"act_relation": "=",
"act_value": "7.98",
"act_comment": "Mechanism of Action",
"act_source": "DRUG LABEL"
}
},
{
"source": "CID:73330464",
"relation": "IDG (Drug Target)",
"target": "338442",
"properties": {
"id": "diroximel fumarate targets HCAR2",
"source_label": "diroximel fumarate",
"target_label": "HCAR2",
"act_type": "Ki",
"act_relation": "=",
"act_value": "6.74",
"act_comment": "nan",
"act_source": "IUPHAR"
}
},
{
"source": "CID:57855696",
"relation": "IDG (Drug Target)",
"target": "5142",
"properties": {
"id": "difamilast targets PDE4B",
"source_label": "difamilast",
"target_label": "PDE4B",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.95",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:78323835",
"relation": "IDG (Drug Target)",
"target": "3716",
"properties": {
"id": "abrocitinib targets JAK1",
"source_label": "abrocitinib",
"target_label": "JAK1",
"act_type": "IC50",
"act_relation": "=",
"act_value": "7.54",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:78323835",
"relation": "IDG (Drug Target)",
"target": "3717",
"properties": {
"id": "abrocitinib targets JAK2",
"source_label": "abrocitinib",
"target_label": "JAK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.1",
"act_comment": "nan",
"act_source": "SCIENTIFIC LITERATURE"
}
},
{
"source": "CID:78323835",
"relation": "IDG (Drug Target)",
"target": "3718",
"properties": {
"id": "abrocitinib targets JAK3",
"source_label": "abrocitinib",
"target_label": "JAK3",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.32",
"act_comment": "Inhibition of N-terminal His-tagged human JAK3 catalytic domain incubated for 20 mins in presence of TK substrate-biotin by TR-FRET assay",
"act_source": "CHEMBL"
}
},
{
"source": "CID:78323835",
"relation": "IDG (Drug Target)",
"target": "7297",
"properties": {
"id": "abrocitinib targets TYK2",
"source_label": "abrocitinib",
"target_label": "TYK2",
"act_type": "IC50",
"act_relation": "=",
"act_value": "6.8",
"act_comment": "Inhibition of N-terminal GST-tagged human TYK2 catalytic domain (871 to 1187 residues) incubated for 40 mins in presence of TK substrate-biotin by TR-FRET assay",
"act_source": "CHEMBL"
}
}
]
}