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20.11.2014

Scleroderma alternative therapies, cold sore remedy over the counter - Plans Download

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According to the Scleroderma Foundation, scleroderma affects approximately 300,000 Americans. Bethany Doerfler MS, RD, LDN discusses top nutrition concerns of scleroderma patients, as well as the results of a recent medical nutrition therapy study. Localized scleroderma only affects the skin, whereas systemic scleroderma will affect the skin, blood vessels, and internal organs.
Systemic scleroderma is a serious condition, while localized scleroderma carries a good prognosis and normal lifespan.
These agents show some promise, but additional study is needed to define their use:Bosentan is currently under study in the US for systemic scleroderma.
Two trials have demonstrated a reduction of new skin ulcers for certain scleroderma patients after taking Bosentan. The drug was approved in Europe in 2007 for the treatment of skin ulcers related to scleroderma.Early study results on a very small number of patients show some promise after non-myeloablative autologous haemopoietic stem-cell transplantation (HSCT) for those with severe disease. Longer follow up and further study is needed to learn if this treatment works and for which patients, as well as to evaluate its safety.Some biologic drugs -- such as rituximab (Rituxan) and Imatinib mesylate (Gleevac), used to treat certain cancers and illnesses that involve an overactive immune system -- may play a role in treating scleroderma.
However, larger scale, randomized, multi-center studies are necessary to determine whether they are beneficial.GuidelinesThe Canadian Scleroderma Research Group (CSRG) convened an expert panel in the area of nutrition to develop new recommendations in the screening and management of nutritional disorders related to scleroderma. There is less than a 1% chance that this disorder will progress to systemic scleroderma.Linear Scleroderma. Rarely, if this type of scleroderma affects children or young adults, it may interfere with growth and cause severe deformities in the arms and legs.Systemic SclerodermaSystemic scleroderma is also called systemic sclerosis.
Both forms are progressive, although most often the course of the disease in both types is slow.Limited Scleroderma (also called CREST Syndrome).
In esophageal motility dysfunction, the muscles in the esophagus become scarred by scleroderma and do not contract normally. This is the stiffness and tightening of the skin of the fingers, a classic symptom of scleroderma.


One or more of the CREST conditions can also occur in other forms of scleroderma.Diffuse Scleroderma. If it gets worse quickly early on, the condition can affect internal organs and become very severe -- even life threatening.Diffuse scleroderma can overlap with other autoimmune diseases, including systemic lupus erythematosus and polymyositis. Localized scleroderma is more common in children than adults, but is extremely rare even in the young age group. A family history is the strongest risk factor for scleroderma, but even among family members, the risk is very low (less than 1%).Genetics. Studies are finding that ethnic groups differ in the number of specific scleroderma-related antibodies they produce. Researchers are evaluating a possible association between certain occupational toxins and systemic scleroderma. It's important to note that more than 80% of patients with Raynaud's phenomenon do not have scleroderma, lupus, rheumatoid arthritis, or other serious illnesses. Raynaud's is more likely to be a symptom of scleroderma or some other connective tissue disease if it develops after age 30, if it is severe, and if it is accompanied by other symptoms (such as skin changes and arthritis).Skin ChangesCourse of Typical Skin Changes. Patients with diffuse scleroderma may have swelling of the whole hand before the skin significantly thickens.Thickened or hardened patches may also develop on other areas of the body. Two major lung conditions associated with scleroderma, pulmonary fibrosis and pulmonary hypertension, can occur either together or independently.Interstitial Pulmonary Fibrosis. Pulmonary hypertension can develop in one of two ways:As a complication of pulmonary fibrosisAs a direct outcome of the scleroderma process itself.
The typical course of kidney involvement in scleroderma is a slow progression that may produce some damage but does not usually lead to kidney failure.Renal Crisis.
It is a rare event that occurs in a small number of patients with diffuse scleroderma, most often early in the course of the disease. However, if the condition is successfully treated, it rarely recurs.Until recently, renal crisis was the most common cause of death in scleroderma.


Aggressive treatment with drugs that lower blood pressure, particularly those known as ACE inhibitors, is proving to be successful in reducing this risk.Heart Symptoms and ComplicationsMany patients with even limited scleroderma have some sort of functional heart problem, although severe complications are uncommon and occur in only about 15% of patients with diffuse scleroderma.
Research has shown that patients with systemic scleroderma have a higher risk of atherosclerosis than healthy individuals.Fibrosis of the Heart. Pregnant women with scleroderma, however, have a slightly increased risk of premature birth and low-birth-weight babies. Although they can carry a baby to term, because complications such as kidney crisis can occur with the disease, pregnant women with scleroderma need to be monitored closely in a high-risk obstetric facility.More than half of scleroderma patients are likely to experience significant depression. In scleroderma, this response produces swelling (inflammation) and too much production of collagen. For some unknown reason, the T cells become overactive in scleroderma and mistake the body's own collagen for a foreign antigen.
The theory arose from the fact that scleroderma occurs mostly in women, and its symptoms resemble those of graft-versus-host disease (GVHD). Despite the fact that women are at higher overall risk for scleroderma, among people who are exposed to solvents at work, men face a higher risk for the disease.
However, no specific work-related factors have been proven to cause the disorder.It is nearly impossible to determine whether specific chemicals may actually cause systemic scleroderma, primarily because few people develop the disease, even though many people are exposed to such chemicals. In addition, research has been unable to consistently repeat studies that have reported links with chemicals.Studies have found, however, that certain industrial toxins are significantly associated with severe lung problems in people with scleroderma. Radiation therapy has been reported to cause local patches of scleroderma (morphea) or worsen preexisting scleroderma in patients.




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