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23.01.2015

New herpes research, herpes simplex 1 how to cure - For Begninners

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Genocea’s GEN-003 is not a herpes cure but rather a “Therapeutic Vaccination” for the moment. We update the blog every couple of weeks with news, events and other things that may be of interest.
Join tens of thousands of doctors, health professionals and patients who receive our newsletters. The researchers found that interferon gamma kept the herpes virus dormant, but when the immune system responded to a helminth infection, the virus would reactivate. The researchers observed that another protein called interleukin 4 was released by the immune system to deal with the helminth, but this blocked the interferon gamma function and also activated the replication function of the herpes virus. Replication of the virus causes new cells to be infected, increasing the chances that a cancerous tumor will form. Earlier this week, Medical News Today reported on research from scientists at the University of Montreal in Canada who suggest that a small molecule found in the urine of pregnant women blocks the growth of Kaposi's sarcoma, as well as a variety of other cancers. In 2013, we also reported on a study that suggested a type of nanoparticle could be used to deliver vaccines that protect against HIV, human papilloma virus and herpes, as well as flu and other respiratory diseases.


Genital herpes is one of the most common types of sexually transmitted infections (STI) in the United States – as well as one of the most frustrating. The discovery could lead to a vaccine capable of preventing herpes lesions on people who have already contracted the STI – or in other words, a vaccine that could “clinically cure” an individual of herpes symptoms.
The newly identified T-cells, called CD8??+ T-cells, reveal a great deal more information about genital herpes than was initially known. Before this study, researchers believed that herpes reactivation was controlled at the ganglion level of the spinal canal area.
Not only did the research team make this significant discovery about the T-cells’ location, they also found that the CD8??+ T-cells are programmed to remain in the skin surrounding the genitals at all times – making them resident memory T-cells. Researchers had originally estimated that herpes reactivated once a month, but the discovery of these ever-present T-cells led Corey and his team to believe the virus actually reactivates once a week or every few days. CD8??+ T-cells were previously known to exist in the gut mucosa, but most of the research on CD8+ T-cells focused on studying them in blood circulation. According to the Centers for Disease Control and Prevention, 776,000 people in the United States are infected with herpes each year, and one out of six people between the ages of 14 and 49 have genital HSV-2 infection.


The good news is the study is still going on and Genocea has updated their website with some promising information.
The researchers believe this explains why cases of herpes can sometimes return after the virus has long lain dormant in a host.
Louis, MO, Renne and his UF colleagues investigated how human herpes virus 8 - a herpes virus linked to the Kaposi's sarcoma cancer - reactivates. Researchers have identified a subtype of immune cells that suppress outbreaks of genital herpes caused by the herpes simplex virus type 2 (HSV-2).
Research and clinical trials are going on to develop a vaccine or at least try to lessen the symptoms. In an effort to find a cure for herpes, Genocea has received a lot of attention with its GEN-003 vaccine and clinical trials.



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Comments to “New herpes research”

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